UA inhibited hydroxyl-mediated DNA damage, indicated ... The synergistic theory of aging proposes that ... with existing theories of aging, may explain avian.
Free Radical Scavenging, DNA Protection, and Inhibition of Lipid Peroxidation Mediated by Uric Acid Beth Stinefelt,1 Stephen S. Leonard,2 Kenneth P. Blemings,1 Xianglin Shi,2 and Hillar Klandorf 1 1 Division of Animal and Veterinary Science, West Virginia University, Morgantown, West Virginia 2 Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Abstract. Uric acid (UA) has been proposed to be the dominant antioxidant in birds. The objective of this study was to investigate the quenching effect of varying concentrations of UA, including those found in avian plasma, on specific reactive oxygen species (ROS) and to determine the ability of UA to protect DNA and cellular membranes from ROS-mediated damage. Hydroxyl (•OH) and superoxide (O2•-) radicals were detected by electron spin resonance (ESR) and their presence was reduced following addition of UA (p
