10 20 30 40 50 60 70 80 90 100

BdaPPO1 BdaPPO3 SbiPPO1 OsaPPO1 ZmaPPO1 SitPPO1 SbiPPO8 ZmaPPO2 OsaPPO2 BdaPPO6 SbiPPO3 ZmaPPO6 SbiPPO4 MguPPO1 BdaPPO2 SitPPO2 SbiPPO2 ZmaPPO3 AcoPPO6 AcoPPO7 AcoPPO1 VviPPO1 VviPPO3 AcoPPO5 VviPPO2 PtrPPO3 MesPPO1 RcoPPO1 PtrPPO11 PtrPPO1 PtrPPO12 PtrPPO5 PtrPPO14 PtrPPO2 PtrPPO9 PtrPPO15 GmaPPO2 GmaPPO4 GmaPPO3 GmaPPO5 GmaPPO6 GmaPPO8 GmaPPO7 GmaPPO1 GmaPPO9 GmaPPO10 PpaPPO4 SmoPPO6 SmoPPO5 SmoPPO7 SmoPPO8 SmoPPO9 SmoPPO4 SmoPPO11 SmoPPO10 MguPPO2 MguPPO5 MguPPO6 MguPPO3 MguPPO4 MguPPO7 MguPPO8 MguPPO9 GmaPPO11 SmoPPO2 SmoPPO3 SmoPPO1 PtrPPO13 VviPPO4 AmePPO1 AcoPPO4 AcoPPO2 AcoPPO3 PpaPPO9 PpaPPO12 PpaPPO2 PpaPPO10 PpaPPO1 PpaPPO7 PpaPPO11 PpaPPO6 PpaPPO8 PpaPPO3 PpaPPO5 PpaPPO13 BdaPPO5 BdaPPO4 SitPPO3 SbiPPO6 ZmaPPO4 SbiPPO5 ZmaPPO5 SbiPPO7 A. marina

10 ....|....| ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSMSEFSCYP ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

20 ....|....| ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTLFTTSVPY ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

30 ....|....| -----------------------------------------------------------MPESF ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLKGNICRSI -----------------------------------------------------------------------------------------MV ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

40 ....|....| --------MA ---------M ------------------------------------WREATKCILR -----MRSLS ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSQ ------------------INYKPQEDWI ---------------------------------------------------------------------------------ALSIDRLELQ ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

50 ....|....| MSTRCHAPLA ASSRC-GPLG -MAGSSSRNG -----MANER ---MAGSNGT -----MAGSN VWAMAGSNGT LSLSLYIYHH --------ME ---------M -------MAR -------------------------MAC ------------------M -------------------------MSL ---------M ---------M ---------M ---------M --------MG --------MA ---------M ---------M --------MS --------MA ------------------------------------------------------------------------M ---------M ---------M KKIDHGFYIL --------MA --------MA ISRIISWLLS ---------M ---------M --------MA ------------------------------------------------------RPSRTRLLKI -----------------MY --------MA ---------M -----------------MA ---------M ---------M ---------M ------MASL ------MGNP ---------M ---------M -------MAA --------------------------ME --------MK --------ME ---------------------------------------------------------------------------------------------------------------------------------------------------------M ---------M --------MN -----------------MN ----------

60 ....|....| ACVFLV---ACVLLI---GLLTLRIILL CRVALFVLIV LLLALRIVLF GALLAFRILL LLIAFRIVLF TSIPAPCTPQ SINVAPGTTA EISTGTPRFT HRSQLT---------------------SIKNTP------------ASMSQL----MASMS----MASMS---SLLATS---SLSLLA---SLSFLA---ASLPWSLTTS ASLPWSLTTS SLSPLN---SLSPPA---ASISPS---GSFFPS---SFTTSI---YNLSPL---------------MAS------MAS----MASCI----MASFI-------------MASCI---ASSTSHPSFW ASSTSHPSFW ASISSHPSFS SILFLPLQFL YISSLSSFSL YISSLS---SLFLVCPSLI ACIPPQSFVS ASKCPFSFVS SISPLSFVPT -----------MFPA-----MSSA-----MSSA---------------------AANARKEANA --MCCI---SLPSMS---SLALSW---ASLPLS-----MASSVQSS SLPLSCATTT ASLHIP---TSLYLS---TSLYLS---HQVLPAAAPS SKLFPFFFAF GRTPSSARIL GRTPSSARIL ATNSSS---------------------TKRWVS---GNRLLHAVLF AKRWLHAVLF ------------------------------------------------MVH------------------------------------------------------------------MSSSVVGTMT --MASP----MATPSAKTN ATPSAAASSS ATASAA---GSMASA-----MASA---GSMASA-------------

70 ....|....| CAVS-MAVYT CAVA-TAVYT CAFA-AAAIT CAFAYAAVYT CALA-SVATT CCALAFTVTV CALASAATTL CRQDREAYMD TPRMAPPPPP SYTLLTPRSR SSAMGSATMP -----MLIAT MLSATMPRGF HIATTGAGGA MASL-SQLIA IARPATFSLS HLIAKPAPAA HLIAKPAPAA TVPS-SSLLN TSTVPSSSLL TTTP-TTTSF TAIANTTNIS TAIANTTNIS YNTITTTSSP TTTT-TNISS TTTPTTISSS TLSTSSFFFP TIST-SSFCP TTSPSAISTS MSTLSFSPFF CISLSSSIPL CISLSSSIPL CLSS-SIPLA SLSS-SIPLA ---------CLSS-SIPLA SLLNLSASIP SLLNLSASIP SLLSFSASFS CTSSHFHLFF SNFSAPLPIS SFSL-SNFSA SLHPFPISIS AAYNVPSKST VVNNASSNSS VNNV-SSNSI ---------ALSLDRIKLQ ALSLDRVKLL ALSLDRVKLK MSPAALSLDR -----MVALS CNSNSSPVTP AAFFDNVFAT -----GMVAL SSAA-AAAAA CYTT-TQFSS CTFLLATNHR TTSATPLRHS CTTTATTPSS CATT-TTASR CATTNTAISA SSSLRSSSST IVFLMPLVSL NNVLPRMVGE NNVLPRMVGD NSLL-SALDR MEAKKLGLVL ---------LIFL-AFILL TFIIVGLFGS TFVMVGLFAS MILVSLNFFL ------------------------------------CVVT-DNFVV MTSL-PSVVI ----------------------------------------MGNFLE ---------MVPFTSSSAS CFLLLQPLAA GLPLVASPRP FLVPATTAVA SSFLVPATAI CATSRPLASA CATSIPLVSA CATS-SPLVS ----------

80 ....|....| A--------A--------L--------S--------L--------L--------L--------STNVASAAPR P--------I--------R--------T--------A--------A--------R--------S--------T--------T--------V--------N--------D--------A--------A--------L--------L--------T--------S--------F--------S--------P--------A--------A--------A--------A-----------------A--------I--------I--------I--------I--------I--------PLPISICSSS S--------T--------T--------A-----------------H--------H--------H--------I--------I--------S--------E--------S--------A--------S--------H--------S--------A--------H--------T--------A--------S--------S--------S--------D--------G-----------------V--------L--------L--------F--------------------------------------------I--------A--------------------------------------------D-----------------A--------S--------P--------S--------A--------P--------P--------A------------------

90 ....|....| ------FP-L ------FP-V ------LP-L ------SPAV ------LP-L ------LP-L ------LP-L PRAPCSLQAA ------CITN ---------P ---------------MP----------------SSPL ------PTTT ---------------FP-L ------FP-L ------NP-L ------VNPL ------RR-S ------FPPS ------LPPS ------YP-F ------QP-S ---------F ------LPNT ------LSKT ---------L ---------------ASSF ------ASSF ------SS-F ------SS-F ---------------SS-F ---------S ---------S ---------P --------FH ----CSSSSA SAFL--TS-Q ------SSST ------LP-S ------TPPS ------PP-S ------------------------------------------------------------------------H ---------------SS-Q ------IS-T ---------S ------PPPL -------TRP ------PF-L ----PSSHPR ---------T ------HNDF ------------------------PR-T ---------I ---------------------------Q ------------------------------------------------------------FR-L ---------------------------------------------------------------------------------------------------T ---------P ------SA----------------PS-----------

100 ....|....| SMSPCTNSLS SVNPCTYSLP VMDPCAHSLS SVNPCAQTLT VTRPCAYSLP ALRTCAYSLS ITRPCASSLS LVRRAAVVRT LQSTLRYNNL YCIRLRSLLH -------SFA -------RGF ---------LV-----KPT VQCYPWSPCS -------PRT SS-----PRT SL-----PRT RS-----NTK RS-----NTK SK-----ATH PLFQRASHVP PLFHRVSHVP PLKKTKISAF PLFHKASQVS FPSFPKTSQL SQ-----ISI SQ-----LSI CPSILKKHAP -----KPQHV LPSFPKTHRV LPSFPKTHQV LPSFPKTHRV LPSFPKTHRV -------MRV LPSFPKTHRV SSVCMFPPSK SSVCMFPPSK SMFPTSQKPC LPNFPNTMQP FLTSQIPCKP IP-----CKP FPLSQTPCKP SLHPFSQSQS SLHPISQFQS PLHPFSRFQS ----------------RSQ -------RSP -------RSR -------KLQ --------DR -------IDR VWDGGTVIDR -------IDR LP-----PPS QP-----PPR RPPPSSPHSL FTKPSLFITR SSRHHFAKPS KP-----QHV PLLPKPSHSH RPVVFAKPSH STFAIKTVSY --------LL --------LL DLRLGRARIQ IT-----IVA -------MIL -------LSS VIKDSNNEEH --VINVSNEE -------RKQ ------------------M -----MKLIC ---------M NI-----DPE -------------------------------------------MRE -------GSR ----------------CLL ---------A -------AYP PSACPSTLPK TPSACPSTVP -------CPS ------SACP -------ACP ----------


110 ....|....| RALLAISGLD RALLAVSGLD RSILAASGLD RALLAVTGLD RTILAASGLD KTILAATGLD RTILAATALD TTKNATTRPR LLHRKTKGWK GSMRSSAPRL APRAPCRSLH AFAAPCRSLQ ALRAPPCCSL HIPTIRKPSH NSSSLKPRRA RSGLRPRRAT SSGFRPRRVT SSGFRPRRVT NRSTVRVGKK NRSTVRVGKK SVARTLIRKR VARNRSCRFA IARNRSRRFA GKPSINRVTR LVGKRNPRFV SLIKKRNHRY NKMRNHSYVG PKNRNCNYVN FVARNQSHPN TKTKRLNHPY SRFKKPNRHN SRVKKPNRPN SRIKKPNRPN SRIKKPNRHN SRIKKPNRHN SRIKKPNRPN KPSKATKRRH KPSKATKRRH QPSKPKRGRH TKRSKPKRHH SKRSKPKGHH TKRSKPKGHH TKHSKPKRHH TKYRKSKHHH TKNRKPKRHH IKNRKPKPHH ---------CPLLPNRSRG CPLLPNRSRG CPLLPNRSRG HRSRCPLLPN LELQRPSRTR LELQRPSRTR LELQRPSRTR LELQRPSRTR NSSVKTQTRR QRFSAQTPPP TPAGRHRRSH HANGSHHHRG HLITHAKRNN ITTHAKPSHP FITHAKLTNR FLTHAKRNHH LVSFSENPNH SRLLVTKFYF SRLLVTKFYF FGGRSGKRLC AFTRILHILE GISVGEISPQ DLFLTDSQQQ THMREQKNQQ HTHMREEKNK NDMNIVQNNQ ---------NSVYVALAVV VLLELLVVVV KLNYVSGVAV DVSSLTRRMS ----------------MAS --MKVMDQLR ---------VYAERGFEMG KDLTGFKMRA ---------M PLTSKPSKHG SATSCTNKRR SMLPKKPTQR KNAAGAGRRR KNKKNAAGRR KKTTAARFRR SKKTTVARFR SKKTAARFRR --MFTSKTRR

120 ....|....| PYITSCADHD PYIVSCAADE AYLLPCTTDA PYVVSCAADD PRLISCADDG PQLISCAGDP PHLISCADDG SLRLSCKAGD PRNVSCR--QHPLRCISRK TLRCRCKATG TTTVRCKATG QTTLRCKATG RHIISCKSTN AGRVRCTLST VHRVPCASSR VQRVSCASPR VQRVSCASPR VAYTSCEQKQ VAYTSCEQKQ FTPTTCEQKH PSKVSCNSAN PSKVSCNAAN RVLITCNARN RRVVSCNATN TPRFSCRATN -RVSSCKTTN PHLISCKATA FHTVSCKARN VPRVSCKATD IPIVSCKSGK IPIVSCKSGK IPIVSCKSGK IPIVSCKSGK IPIVSCKSGK IPIVSCKSGK AWEVACNGNP AWEVACNGNP ASKVACNGNP VSKVTCNSNQ VSKVSCNSNQ VSKVSCNSNQ VSKVSCHSNQ TPRVTCNSGN IPRTTCSENQ IPRITCSGNQ --MYTCK--ALKITASARK ALKITANARK TLKITANARK RFKITANARK PLKIAANARK PLKIACNSNS PLKIAANARK LLKIAANARK CNNITCKATN TRRFQVRSTG LFQVSCKQQN LHVISAQKQN RLQISCSDSQ LHQISCSSTT LHHVSCSSTP RRLISCSSSS NGHITTSSNE PVQILCFLLL PVQILCFLLL TTTIKCVHEG APEVQHALLG HHDVDAKKHMKPISF---VSIISTSFLW LVSISTTFLW QVSISTPFLW -MKFTCVLL-----------LLMC---AVLLACVLVE TSQIMTTFTG -LAVLCAV-RIASLC---RVPISAMK----MKCAALV GLVLARNF-AVLILSQILLMRITS---RRRLSCKAMA PRRVSCNATP RRSLSCRAAA HRTMQCRASS RRTLQCRASG RRTVSCRATA RRTATCRASS RRTVSCRATG EFLISA----

130 ....|....| DASAARLSDDAFTAPLSNSKAPSSHGKD GVSTPLLSDSAKAQLSDGD ATKAPLSGYSKSNAELSEG DDDG--------------AAASDGDNRT GA-------AA-------GA-------NHDQEPAGKDATGGRAEHD GEERSEPDAP GERSEHDAPK GERYELDARK SNEG----DS SNEGDSHT-EGNGVGVNAE GDPNSDSTSD GDPNSDSTSD EESMGK---GDERSTSSSK DDSQNPTT-DNDHQNPTTNDHDQNPTTDDHQNPST-DTQNPPT--NDHEQNPATNDHEQNPATNDHEQNPATNDHEQNPATNDHEQNPATNDHEQNPATRN-------RN-------NP-------NTPTPNPEEE NTPTPNPEEE NTPTPNPEEE NNSAPNPEEG QNKGEKPDIH NNPTPNPSEG NNPTPNPNSQ ---------EANAAAGESG EANAATGESG EANAATGESG EANAAKSSNEANACNSNSS SPVTPS---EANACNSNSS EANACNSNSS NDKNTEPTQK GPNNEKGENS PPPPSSEGKDNPESTHPQG KQKDSSQNAD SQNQNDDTKS QNQNDETKKP SNEGSK---RDKSRLWR-STATGRR--STATGRR--EEHARRSGRT EFN------------------------FKNIASSLAF LKKIVSSLAF LKNIVSSFAS ------------------------------------AMMALTF-----------------------------------------------------------------SSGDDDDSYR SSRSSTPTGD PR-------GGGRRGDGDD RRGDDEDSRGGDNDGLLWP GGGGGRGGEN GDND---------------

140 ....|....| ------------------ANRTSG------------------------------D--------------------------NV-------------------------------------------GPR------K-----------------H--------HT----------------RSG------VRETSSGK-IRETSPGK----------SGESP----------------------------------------------------------------------------------------------------------------------------------RPSYN----KPSSY----KPSSY----KPSHN----I--------ELSHI----GEPPH-------------NPSFPSKKGS NPSFPSKKGS NPSFPSKKGS -PSFPSKKGS PVTPS-------------PVTPS----PVTPS-------------PPNGG-------------K--------TPQGN----QSGKV----TAKV-----------------------------------------SD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GEEDM-------------VDSRL----------------------D---------------------------

150 ....|....| ---------------------------------------------------------------------VDRR ------VDRR ------VDRR -------DRR -------DRR -------DRR ------FDRR ------LDRR ------HDRR ------HDRR -------DRR ------IDRR ------IDRR ------IDRR ------LDRR ------LDRR ------LDRR ---LGKLDRR --------RR --------RR --------RR --------RR --------RR --------RR --------RR --------RR --------RR --------RR --------RR --------RR --------RR ------RNRR ---ILGKYRR --NILGKHRR --NILGKHRR --IVAGKNRR ------EQRR -----VGHRR ----IVGHRR ---------STPASIIDRR STPASIIDRR STPASIIDRR STPASIIDRR ------IDRR ------IDRR ------IDRR ------IDRR ------LDRR -----KFDRR ------VDRR ------LDRR ------VDRR ------VDRR ------VDRR ------VDRR ---------------------------------VNRR -----------------------IRDLK ---------------------------------------------------------------------------------------------------------------------------------------------IDRR --QPRRLDRR ------FDRR ----LWLPRR ---LLWLPRR ------LPRR --GLLWLPRR --GLLWLPRR ----------

160 ....|....| ---------------------------------------------------------------DVLLGLMAGA DVLL-----DVLLGL---DVLLGL---DVLLGL---DVLLGL---DVLIGL---DVLLRL---DVLLGL---DVLLGL---DVLLGL---NVLLGL---NVLLGL---DVLVGL---NVLLGI---NVLLGI---NVLLGL---NVLLGL---DLLIGL---DVLIGL---DILIVL---DVLIGL---DVLIGL---DLLIGL---DLLIGL---DLLIGL---DVLIGL---DLLIGL---DLLIGL---DILIGL---DILIGL---DILIGL---DVLLGI---DILLGI---DVLLGI---DVLIGF---NILLGL---NVLLGL---NVLLGL------------ELLA-----ELLA-----ELLA-----ELLA-----ELLA-----ELLA-----ELLA-----ELLA-----NLLLGI---NLLMGM---NMLLGL---NVLLGM---NVLLGF---NVLLGM---NMLVGM---NMLLGL------------------------------EFVL-----------------------KTILGIFD----------------------------------------------------------------------------------------------------------------------------------------DVLLGLTAAT EVVLV----DVLAGLTGVA QVLTGL---EVLTGL---DVML-----DVMLNGLSSV DVML---------------

170 ....|....| -GGGSDNI--GGNDDKN--GGNTGA---GGHDKINAG -GGHNKAGSG -GGDAGNKAG -GGNKPAGSG GAAAAGIASN --GISGAAAM -GAGAAAAIG -GGAAAAGLL -GGAAASGLL -GGAAAAGLL -GGLYGATTL -GTLGASATA -GALGASATL -GALSASATA -GALGASATA -GGLYGASAT -GGLYGASAT -GGLCGATAT -GGLYGAAGG -GGLYGAAAG -GGLCGLSGL -GGLYGVSGL -GGLYGATSL -GGFCGATTL -GGLYVAITL -GGLYGATNL -GGLYSATNL -GGLYGATSL -GGLYGATSL -GGLYGATSL -GGLYGATSL -GGLYGATSL -GGLYGATSL -GGLYGATTS -GGLYGATTS -GGLYGATTL -GGLYGASAL -GGLYGASAL -GGLYGASAL -GGLYGASTL -GGLCGAATL -GGLCGAVTL -GGLCGAVTL ----------GTIAGGASL -GTIAGGASL -GTIAGGASL -GTIAGGASL -GAIAGGASL -GAIAGGASL -GAIAGGASL -GAIAGGASL -GGVYGGAAH -GGLYSAANL -GGLYGAANL -GGLYGAAAS -GGLCGAANL -GGLCGAANL -GGLYGATTL -GGMYGAANL -KAFIGLKNT -EASLGLATG -EASLGLATG -GSIGGGAAA -FIIPGMLKL ----------GTWVSMETT -ADWQFNKVP -GDWQFNKVP -GDWQWDKVP -VVLAVLLAL -AALFALCPQ -AQVY--------------LAIIGIITL -GSIALVKIV -GVLATVFVI -GVIYAAVLS -LVLSVSFTL -GVVTWGSIL -GDFTS------------TGSTLGRARG -GGLTGAAAA AGGLATRPGL -SGVAAGFVG -GGVAASFVG -NGLTGVAAG AAGLAWYPGV -SGLSGVAAG -GAATALF--

180 ....|....| -I--------I----------------RV----------------SG----------------NTHGSSSALVATQGGGGAL APRRAL---SSSLSNRGGA RSSSSSSSGTSSSSRGGAI SASPFAF--GLLSSPRLAG MSARRAG--TLVTARRAGTLASARRAGIGSQGKIAMIGSQGKIAMFGSNMAV--LGATKPLAFLGATKPLAFSATDNRLAMGAADPFAF-SDPFAF---ADHPFAF--GDPLAF---SDPFAY---ADRTAF---SDPFAY---SDPFAY---SDPFAY---SDPFAY------------SDPFAY---LTSNNTGSAF LTSNN----SGNSTGSAFSNTNPLAMASNTNPLAMASNTNPLAMATNNNNNNPLA NNNPFAF--NNNPFAF--NNNNPFAF----------AASPTGPVLAASPTGPALAASPTGPALAASPSGPALASSVDSHALASSVDSPALAPSVDSPALASSVDSHALLLSADNPPAA VPTDSPAS-IPTNPEAATLVSTPPEASISTHTAS--VSNTPAAS-ASTPSAA--LSTPDSAS-HEPSSNI--SLQQEQQAWSLQQEQQGWTLPAAGAL-ASSPGKDQQ---------SSSSTSEK-VSKNP----VSEHP----VSKHP----NLRVD----VE-------------------------VQTVE----D--------YLIAPTE--MVFAWTEATT VEATT--GKAMLIVNVVT------------------LLAAEGV--NLGLMPALAG AATEDASD-YPDDLASIAL YPDLASIALE LAWYPGVASASGADAVCTR LACYPGLADA ----------

190 ....|....| -----GGP------GGP------RRP------GGP------GRP------GRP------GRP------AAP------AAP------AAP-L----AAP------GAP------AAP------AAP------AAP------ADP------ADP------ADP------GAP------GAP------GAP------GAP------GAP------AAP------AAP------AAP------AKP------AKP------AKP------AKP------ANP------ANP------ANP------ANP---------------ANP------GAS---------------GAP------AAP------AAP------AAP-I----AAP------AAP------AAP------AAP------KHA------AEP------AEP------AEP------AEP------ADP------ADP------ADP------ADP-F----AAP------ATP------ASP------ANP------ANP------ANP------ANP------ANP------SRA------ARP------ARP------ANP------EKP------AKN------KNPKF -----EKPQK -----EKPHR -----DKPHR -----GAP------GAP------GAP------GAP------GKP------GKP------GKP-RPRGPGGP------SRA------AVP------GVP------GTP------KQP-DD---TEP------VCPRG ALE--ANP------ANP------GADSS -----ADK-AECTRSDK-----------

200 ....|....| -IVT------IVT------IIT------IVT------IVT------IVT------IVT------VQA------IQA------IKA------IPA------IQA------IQA------ISA------VAT------VAT------VAT------VAT------VAP------VAP------VQP------IQA------IQA------IMP------ISP------VSA------ISA------VSA------IQP------ITP------IAP------IAP------IAP------IAP---------------IAP------LSP---------------VSP------ILQ------ILE------ILE------ILP------ISP------ISP------ISP------VVP------VGS------VGS------VGS------VGS------IGL------IGP------LGL------IGL------ITS------ISS------IEP------VQA------VQA------ILP------IQA------IQA------ISL------IDN------IDN------VEL-----LVIL------VVS-----VVLS-----FGIS-----VGLS-----VVFS------FPP------FPP------FPA------FPA------FPA------FPA------FPA------MPA------LPA------LPP------IPA------VPA------MPI------AAT-CITAP EKVT------VESCRRGEK -VESCRRGEK TTSPCTAADK -VNE------VNE------FLP------


210 ....|....| --NLLT--CG --NLLT--CG --DQL---CV ---DLLQ-CR ---DLLS-CG ---DLRW-CG ---DLLS-CG --PDLQA-CR --PDLGD-CH --PDLRD-CH --PNLSN-CH --PDLRN-CH --PDLRD-CH --PDVTK-CG --PDISS-CG --PDIST-CG --PDISS-CG --PDISS-CG --PDLSK-CQ --PDLSK-CQ --PDLSA-CR --PDISK-CG --PDIRK-CG --PDLSK-CG --PDLSE-CG --PDISK-CG --PDITK-CG --PDLTK-CG --PDIAD-CS --PDLTK-CE --PDITQ-CE --PDITQ-CE --PDITQ-CE --PDITQ-CE ---NITQ-CE --PDITQ-CE --PDPTN-CV --------TG --PDPTN-CV --PDLEH-CC --PDLEH-CC --PDLEH-CC --PDLKT-CG --PDLTT-CG --PDLNT-CG --PDLNT-CG --PYSTV----PTFKR-CQ --PTFKR-CQ --PTFKR-CQ --PTFKR-CQ --PSFKH-CH --PTFKR-CH --PSFKH-CH --PSFKH-CH --PDISK-CT --PDLSK-CS --PEFKA-CG --PQLDK-CG --PQIDK-CG --PELNK-CG --PELNK-CG --PQIDK-CG ---NARE-CF GTIDLEW-CT GTIDLEW-CT --GSISS-CS --PNLTS-CH --PNLTT-CH --PNLTT-CH --PNLSS-CH --PNTSS-CH --PNLSS-CH --PQFRL-CQ --PQFRN-CR --PQIRY-CS --PLIKL-CK --PDLKL-CN --PDFKL-CN --PDLKL-CS --ANLPEDCN --ANLPEDCN --PDVAEYCN --PEFPEKCT --PILPDNCT -TSEVLK-CV ITDKLIK-CV --DTLLT-CQ VTDKIVE-CS VTEKLVE-CS VNEKVLQ-CT --KTVQ--CT --NTVQ--CT --------TK

220 ....|....| NA-------T KP-------K KG-------V KP-------E EP-------R EP-------S EP-------D TP-------D QP------VD AP------ED PP-------D PP-------D PP-------D PA-------D KP-----DLG PA-------D PA-------D QA-------N LA-------LA-------LA-------TA-------T TA-------T PA-------D AA-------D RA-------D EA-------D KA-------D VI-------N LV-------D LV-------T LV-------T LV-------P LV-------T LV-------P LV-------T QP-------SA-------PP-------IT-------D IT------DD IT------DD PP-------D PP-------D PP-------D PP-------D ---------PA-------K PA-------N PA-------N PA-------N FP-------QA-------RA-------RA-------TG-------RG-------AA------RD TA-------VA-------TA-------TA-------NS-------PV-------E QA-------E QA-------E PA-------E ES-------ES-------KS-------SS-------KS-------NSTNIWDFDP SA-------SL-------NT-------ST-------YT-------LA-------YA-------TL-------TI-------SE-------SE-------SE-------SA-------SS-------KT-------DP-------DP-------DT-------DP-------DT-------VA--------

230 ....|....| LPPHAL---P LPPHAL---P LPPHAL---P GPDFP----E LPSHAL---P LPPHAL---S LPSHAL---P VPATA----A VPATA----P LPEAIT---G LPDTV----S LPDTA----E LPDTV----G LPQGA----A LPPNA----N LPPGA----N LPPSA----N LPVSA----N ---TDAANGE ---TDEANGE ---NDLQLVN VPDGV----T VPNGV----I FPPGS----Q LPAGA----Q LPTGA----N FPAGA----K LPSSA----K EPDPE----N LPNPE----N LPTES----D LPSES----N LPSES----D LPTES----D LPTES----D LPTES----D -------DPE ---------LLPGE----N DVPPKGVIEA VPKGEIE--K VPPKGVIE-A LATGA----K LPEGA----E TPAGA----N LPAGV----K ---------V IENTN----T IANTN----T IANTN----T IANTN----T ----SVGDDI ----TIGDDI TISDD----I TISDD----I TNLNTQKP-L TDLSTQQP-L VQSGDL---L -TDLNTGKKL -TNLNTGKQL TNWNNGESLD -TNLNNGEKL TYDTSAGVAT LPSDAI---T TPAGK----TPAGK----LPPGA----T MGRSD----L VPRPG----L LSDAD----R -FANPVLVSM FAKPG----F IHPVA----F -------------------------------------------VRS -------FGS -------FNS ---------------------------------------------------------------S ------------------N ---------N ---------A ---------A ---------E ----------

240 ....|....| PFYCC----PFYCC----PFQCC----DLQCC----PFRCC----PFHCC----PFRCC----DPSCC----AINCC----ATNCC----DINCC----DVNCC----DVNCC----PTNCC----LLTCC----VVTCC----VLTCC----VLTCC----QVYCC----QVYCC----RVDCC----ATNCC----PTNCC----PTNCC----PTNCC----ETNCC----PTNCC----PTNCC----PTNCC----PSNCC----PSNCC----PTNCC----PSNCC----PSNCC----PSNCC----PSNCC----KDPFC-------------DVNCC----QVYCC----QVYCC----QVYCC----PVNCC----PTNCC----PTNCC----PTNCC----S--CC----FVACC----FVACC----FVACC----FVMCC----IRVCC----NRACC----NRRCC----NRRCC----DINCC----DVNCC----NINCC----DLNCC----DINCC----GINCC----DINCC----QINCC----STRCC-----VGCC-----VGCC----PVNCC----PVYCC----SVYCC----PVYCC----PVYCC----QVYCC----PVYCC-----DRCC-----DGCC-----TGCC-----QGCC----FEGCCT---TEACCT---TEGCCT----ERCC-----ERCCMLHAK -ERCC-----ENCC-----EGCC----GDFVC----DGFRC----GQKPC----RGFPC----RDFPC----NQKPC----GQLPC----GALPC--------------

250 ....|....| ----PPMTT----PPMSA----PPPPST ----PPMPT----PPTPAS ----PPAPVS ----PPTPPS ----MTYRAG ----PTYSAG ----PTYDG----PPGAG----PS-------PPGAG----PPPT-----PPPSN----PPPSA----PPPSN----PPPSS----PPYSS----PPYSS----PPYGT----PPVT-----PPVT-----PPTD-----PPVS-----PPVPS----PPQS-----PPPS-----PPLT-----TPLP-----PPTS-----PQTS-----PPTS-----PPTS-----PPTS-----PPTS-----PP----------------PP-------PPRSS----PPKSS----PPKSS----PPIS-----PPFS-----PPS------PPS------PPLPT----PPKPK----PPKPK----PPKPK----PPKPK----PPKPK----PPKPK----PPQPK----PPQPK----PPQS-----PPVV-----PPTS-----PPVT-----PPMG-----PPLT-----PPIS-----PPFT-----PPRPSP ----PPRST----PPRSK----PPPNS----PPMNQS ----PPKPES ----PPKRES ----PPNIES ----PPKPES ----PPKSES ----PPVSQ----PPVNR----PPPDA----PLPDS----LPVRL----LPERL----LPAPP----MPKPYT AIYGMPRPYT ----MPRPYV ----MPYPYT ----MPQPYT ----PAGSTD ----PVAYLP ----PPTSP----PPATR----PPASR----PLVSP----PLVSP----PLVSTT ----------

260 ....|....| ---AEPINF---SEPIDFSSASGPINF---SEPIDFD--AAVANFE--PAVINFG--TPIANFLAPPAIIDF---TVAVDF---TGIVDF---TAIVDF---PGIVDF---TAIVDF---ATIVDY---ALPVDF---ALPVDF---ALPVDF---ALPVDF---ADIKPF---ADIKPF---TTITDF---TKIIDF---TKPIPF---LKIVDF---SKIIDF---TKILDF---TKILDF---TKILDF---RKIIDF---KKIIDF---TKIKNF---TKIKNF---TEIKNF---TKIKNF---TKIKNF---TKIKNF---PPFKDY------------SPIVDF---SPPIDF---SPPIDF---SPPIDF---STIIDF---STIIDF---SKIIDF---SKIIDF---RPIKDF---RDTIDF---RDTIDF---RDTIDF---RDTIAF---RATIDF---GATSYF---RATIDF---RATIDF---AEIIDY---DGITNY---DKIVDF---DNIIDY---KNIIDF---TDIIDY---DRIIDY---GTIIDY---SNIIDFK ---TSVVDF---TPVVDF---SPIVDFN--VAIIDFE--EPFIDFL--EPIIDFD--EQIIDFE--EPVIDFN--EPVIDF---KPPVPF---KPPVPF---RVPVDF---RTPVDF---GSLKKF---NPLKEF---GPVKKFGT-PGIRQFGK-PGIRSFG--QPAHQFG--KPVRQFG--KPARDFYDDATVVNFS ---EDVIDL---VAAVDF---IPVVDF---VPIVDF---SSPVDF---TDPVDF---APVVDF----------

270 ....|....| TFP----DPS TFP----DPS TFP----DPA TLP----DPS TFP----DPG TFP----DPA TFP----DPG QPPRASSSSS APP----PAS ELP-VSAGSS TPP-----PT TPS------TLP-----PA KFP----PPS SPP----DAS TPP---DAAS TLP---DATS ILP---DATS VPP-----ND VPP-----ND VLP----DQS QLP----SSD QLP----SSD KLP----SRS KLP----PKN KRP----PSN KLP----SSN KLP----SSN KLP----SQN RPP----SPF EFP----SAS EFP----SAS EFP----SAS EFP----SAS EFP----SAS EFP----SAS ELP-PHDDKT ---------EFP-----SH KLP-----KG KLP-----KG KLP-----KG KLP----SSG KFP----PSN KFP----PSN KFS----PSN KFE----DQT KPD------T KPD------T KPD------T KPD------T KPD------S KPD------S KPD------S KPD------S QLP-----PV KLP-----PV KLP----PPP KIP-----PA KPP-----PL KLP-----PV KLP-----PV KLP-----NF DFA----SPN VHN-----TQ VHN-----TQ QYN-----TR QFP----DPS QFP----DPS QFP----DIS EFP----DPS EFP----DPS EFP----DLS QFQ-----TG QLP-----TN FFQ-----PG TFR-----PN DFQ-----PQ DFQ-----PH DFK-----PR EYE-----PN EFP-----KD YPD-----PE TID-----PN EGD-----LA DLP----APT ASLPGPPPTG TPP------T TPE------P TPE------A TPE------T KPE------S TPE------T --------QA

280 ....|....| EPLRVRRPAH EPLRVRRPAH EPLRTRRPVH EPLRTRRPAH EPLRTRQPAH APLRTRRPAH EPLRTRRPAH SPLRVRPAAH SPLRVRPAAH PVTRVRPAAQ VGRRVRPAAH PRLRVRPAAH VGLRVRPAAH TTMRVRPAAH TPLRTRPAAH SPLRRRPAAH LPLRTRPAAH LPLRTRPAAH GILRKRKPAH SILRKRKPAH EPMRVRRSAE SPMRTRPAAH SPMRTRPAAH TPMRVRPAAH SPLRIRPAAH APLRVRPAAH SPLRIRPAAH SPLRIRPAAH EPLRIRRPAH SPLRTRRAAH SPMRIRPAAH SPMRIRPAAH SPMRIRPAAH SPMRIRPAAH SPMRIRPAAH SPMRIRPAAH LPLRIRPAAH ---------KRLRHRRPAQ TPLRVRPPAQ TPLRVRPPAQ TPLRVRPPAQ APLRVRPAAH KPLRVRPAAH QPLRVRPAAH QPLRVRPAAH LPMRVRRPAH GPMRTRPAAH GPMRTRPAAH GPMRIRPAAH GPMRTRRPAH GQMRVRPAAH RPMRVRPAAH GPMRVRPAAH GPMRVRPAAH TQMRYRPAAH TKMRFRPAAH AKLRVRPPAH LRMKLRPSAH VQMRTRPSAH FRMKIRPSAH FQMKIRPSAH PKTKVRPSAH ATLRVRKPAH LPSRLRQPVH LPSRLRQPVH LPQRLRRPAH LPLRVRRPTH SPLRLRRAAH SPIRVRKPAH EQLRIRKRAH VPLRIRKRVH APLRVRKRAH LPWRTRIAAQ LPWRTRRAAQ LPMRVRSAAQ LPIRIRRAAH LPMRVRPAAH LPMRVRPAAH LPMRVRQAAH LPIRVRRPAH QPTRIRKPAQ LPIRIRRPVH LPLRIRRPVH LPIRIRRPVH GPPRVRRPAH GPLRVRRPAH GPTRLRQPAH KVTRIRQPAH RVTRVRRPAH KVKRVRQAVH KVTRIRQPVH KVTRVRQPVH QELRTRKNVA

290 ....|....| --A------V --A------V --V------V --V------A -GA------A --D------A --ESGSGSGT --L------V --L------A --L------V --L------V --L------V --L------V --L------A --S------V --S------V --S------V --S------V --K------L --K------L ALA------S --L------V --L------V --L------V --L------A --L------A --L------V --V------V --L------V --L------V --L------V --L------V --L------V --L------V --L------V --L------V --L------V -----------W------V --F------V --F------V --F------V --L------V --L------V --L------V --L------V --K------V --L------V --L------V --L------V --L------V --L------V --L------V --L------V --L------V --L------A --L------A --R------V --R------V --R------V --R------A --R------V --R------L --M------V --L------L --L------L --L------L --L------L --L------V --L------V --M------R --L------R --L------P --F------A --L------V --F------V --L------A --L------I --L------V --L------V --L------L --H------L --L------L --K------L --K------L --L------L --L------L --L------A --L------L --L------L --L------L --L------L --L------L --S------P

300 ....|....| GAEY-MAKYE GAEY-MAKYE GAEY-MAKYA GAEY-MAKYE GADS-VARYA GAAGDMAKLA DNSV-VARYA DSAY-VAKYE DRAY-LAKYE DAEY-VAKYE DEEY-VAKYE DAEY-VAKYE DEEY-LAKYE DKAY-VAKFN GADY-VAKLN TADY-VARLN TADY-VAKFN TTDY-VAKFN NRKE-IEDFK NRKE-IEDFK DPVY-LEKFR SKEY-LAKYK SKEY-LAKYK DDEY-IAKYS SKEY-IAKYK DKDY-IAKYK DESY-VAKYS DDAY-LAKYS DDNY-IAKYN DEDY-VAKYA DKAY-VAKYA DKAS-LAKYA DQAY-VAKYA DKAY-LAKYA DKAY-VAKYA DKAY-VAKYA TDDY-IAKYE -----FAKYE DDDY-LNKYK TDEY-LEKYK TDEY-LEKYK TDEY-LEKYK NDVY-IAKYR DKNY-LAKYK NDEY-LAKYK NDEY-LAKYK DAAY-IEKYN DEDY-IQKYN DEDY-IQKYN DEDY-IQKYN DEDY-IHKYN DKDY-IAKYN DKDY-IAKYN DKDY-IAKYN DKDY-IAKYN GKEY-YAKFE GKEY-IAKYE SKEY-LAKFE SAQY-MFKYN SAEY-MFKYN SAEY-MYKYN SPEY-MFKFN SPEY-LFKFN DEEY-IAKLE SSDY-IAKYI SSDY-IAKYI RPDE-IARYN DDNY-ISKYK DDDY-IAKYR DADY-IAKYN DSDY-IAKYA DSDY-IAKYT DRDY-IAKYA DAKY-IAKYQ DAAY-IAKYH DGKY-IAKYR DDAY-IAKYR DDAY-IAKYQ DDAY-IAKYQ DDAY-IAKYQ TKKE-IARLE DKAY-VKKLE TDAE-VARLE NDDE-IAKLE NESE-IARLE SAQE-VEKLE DAAY-VKKYE DPET-VEKYR DAEY-QAKYK DPEY-QEKYR SREN-QEKYK SREY-QEKYK SQEY-QEKYK DAEGDLASLR


310 ....|....| RVIALMKALP RAIALMKALP RAVALMKALP RAIALMKALP RAVALMKALP RAVALMKALP RAVALMKALP RAVALMRELP RAVSLMKKLP KAIRLMKDLP KAVALMKELP KAVALMKQLP KAVALMKELP RAMELMRALP RAMAAMKALP AGIAAMKALP AGIAAMKALP AGIAAMKALP RGIQLMKELP RGIQLMKELP RAVALMKALP KAIELQKALP KAIELQKALP RAIALMKALP KAIELMKALP KAIELMKALP KAVELMKALP KAIELMKALP RAIALMKQLP EAISLMKSLP KAIALMKSLP KAIALMKSLP KAIALMKSLP KAIALMKSLP KAIALMKSLP KAIALMKSLP EAVRRMQDLP EAVRRMQDLP EAVRLMRALP LALKRMRELP LALKRMRELP LALKRMRELP EALKRMKALS KAIDLMKKLP KALDLMKKLP KALDLMKKLP RAYRLMRALP EAYAKMRALP EAYAKMRALP EAYAKMRALP TAYAKMRALP EAYAKMRALA EAYAKMRALP EAYAKMRALS EAYAKMRALS KAVALMKALP KAVAAMKALD EAIRRMKALD LAVDRMKRLP TAIDRMKRLP LATDRMKRLP TAIDRMKRLP TAVDRMRRLP KGIALMKALP RAYELMKALP RAYELMKALP RAYQLMRALP KAITIMKSLP NAVSIMKSLP KAIAIMKSLP SALSIMKSLP RALKIMKSLP RALSIMKSLP RAYQLMKALP RAYGLMRALP KAYAAMRALP LAYKRMAALP RAVEIMRALP RAMELMRALP KAVELMRALP KGYKLMRALP KAYKILRELP RAYQLQKDLP KGYQLLRSLS RGYKLLRELP LALQRMKELP AGVRMMKALP RALAKMKALP EAVRKMRALD EAVGKMRALD EAVAKMKALP EAVAKMKALP EATSKMKALP DGVSEMKRLI

320 ....|....| H---SDPRSF D---SDPRSF Q---SDPRSF R---SDPRSF E---SDPRSF A---SDPRSF E---SDPRSF D---DDPRSF A---DDPRSF A---DDPRSF D---DDPRSF D---DDPRSF D---DDPRSF D---DDPRSF A---EDPRSF A---GDPRSF A---DDPRSF A---DDPRSF E---TDPWSY E---TDPWSY A---DDPWNF D---DDPRSF D---DDPRSF D---DDPRSF D---DDPRSF E---DDPRSF D---DDPRSF D---DDPRSF E---DDPRNF E---DDPRNF D---DDPRSF D---DDPRSF D---DDPRSF D---DDPRSF D---DDPRSF D---DDPRSF P---DDPRSF P---DDPRSF L---DDPRNF S---DDPRSF S---DDPRSF S---DDPRSF P---NDPRNF A---NDPRNF S---DDPRNF S---DDPRNF Q---DDPRSF S---DDPRSF S---DDPRSF S---DDPRSF S---DDPRSF P---DDPRSL P---DDPRSL R---GDPRSL R---GDPRSL A---DDPRSF KTDPTDPRGY KSDPSDPRGF D---DDPRSF K---DDPRSF A---DDPRNF K---DDPRNF K---DDPRSF D---DDPRNF P---DDPRNF P---DDPRNF A---SDPRRF D---TDPRSY Y---DDPRSF Y---DDPRNY Y---DDPRSF Y---DDPRSF Y---DDPRSF N---SDPRSL N---SDPRSL R---SDPRSL N---TDPRSL D---TDGRSY E---TDGRSF E---TDGRSF D---TDPRSL D---SDPRSL D---SDPRSF E---SDPRSL D---LDPRSL D---DDPRSF D---DDPRSF A---SDPRSF K---SNPLSF G---SNPLSF E---SNPLSF E---ENPLSF E---SNPLSF NTDPEDPRGW

330 ....|....| YQVANIHCAY YQMANIHCAY YQQANIHCAY YQQAHIHCAY YQQANIHCAY YQQANIHCAY YQQANVHCAY AQQAHVHCAY EQQWRVHCAY EQQWRVHCAY TQQWRVHCAY AQQWRVHCAY AQQWRVHCAN KQQAAVHCAY AAQASIHCAY AAQASVHCAY AAQATVHCAY AAQASVHCAY YQQATIHCTY YQQATIHCTY MQQAQIHCAY KQQANVHCTY KQQANVHCAY KQQANIHCAY MQQADVHCAY MQQADVHCAY KQQADVHCAY MQQANVHCAY TQQANVHCAY YQQANVHCAY KSQADVHCAY KSQANVHCAY KSQADVHCAY KSQADVHCAY KSQADVHCAY KSQADVHCAY MQQANVHRAY MQQANVHRAY MQQAKIHCAY KQQADIHCAY KQQADIHCAY KQQADIHCAY TQQANVHCAY MQQANVHCAY TQQANVHCAY TQQANVHCAY HQQSNIHCAY RQQANVHCVY RQQANVHCVY RQQANVHCVY RQQANVHCVY RQQANVHCAY RQQAKVHCAY RHQAKVHCAY RHQAKVHCAY MQQANVHCAY SQQANVHCAY MQQANIHCAY SQQAMIHCAY MQQANIHCAY MQQANIHCAY MQQANIHCAY MQQANIHCAY IQQAKVHCAY DQQANVHCAY DQQANIHCAY SQQANVHCAY TRQANLHCLF LSQANLHCIY MRQANMHCIY ARQADVHCIY GRQADMHCIY GRQADIHCLY YAQARMHCAY YAQARMHCAY YAQAQLHCAY YAQANLHCAY LAQYRLHCAY QAQYRLHCAY TAQYRLHCAY LNQMNLHCLY KNQMNLHCLY TNQAKLHCLY SNQAKLHCLY SNQANLHCLY KNQAAIHEAY KSQATIHEAY AAQAAIHEAY AAQAAVHESY AAQAAVHQSY KAQAAIHQAY AAQAAIHQAY AAQAAIHQAY ILQAYIHGN-

340 ....|....| CTT-SYR-QCTG-SYR-QT CTG-AHR-QL CTG-AYR-QV CTA-AYR-QA CAG-AHR-QA CAA-AYR-QA CNG-AYG-QA CDG-AYD-QV CDG-AYD-QA CDG-AFD-QV CDG-AFD-QV CDG-AFD-QV CDG-AYD-QA CNG-SYG-VE CDG-SYS-PN CDG-SYS-PE CDG-SYS-PE CNG-AFD-QV CNG-AFD-QV CND-AYT-QV CQG-AYD-QV CQG-AYD-QV CDG-AYD-QV CNG-AYH-QV CNG-AYD-QV CDG-AYH-QV CDG-AYH-QV CDG-GYH-QV CNG-AYE-QV CDG-AYH-QA CDG-AYH-QA CDG-AYH-QA CDG-AYH-QA CDG-AYH-QA CDG-AYH-QA CDGRGYT-QK CDGRGYN-QK CHN-GYR-QK CDG-GYK-QL CDG-GYK-QL CDG-GYK-QL CDG-AYH-QV CTG-SYD-QV CDG-AYH-QV CDG-AYH-QV CGF-GFK-QL CNF-GYR-QE CNY-GYR-QE CNF-GYR-QE CNY-GYH-QE CSY-GYR-QE CNY-GYR-QK CNY-GYR-QE CNY-GYR-QE CNL-TYP-QT CNL-TYE-QS CNG-AHD-QV CNG-AYD-QP CNG-AYD-QP CNG-AYD-QP CNG-AYD-QP CNG-GYD-QP CNG-AYHLRH CDG-AFL-YA CDG-AFL-ET CND-SFR-QA CTG-AYN-QQ CTG-AYK-QK CTG-AFI-SE CTG-SYN-KK CTG-AYN-QK CTG-AYN-QK CGA-AFY-YP CGG-AFY-FP CGG-AFK-YK CGG-AFK-FN CNN-HLY-YE CNNHLYY--CNN-HLH-FP CDN-GLY-FK CDN-GLY-FP CDS-GIY-YP CDN-GIY-YP CDN-GIY-YN CDG-KYN-VV CNF-HYK-FL CDG-HYR-YG CDG-HYR-LD CDG-HYR-LD CDS-YYS-YH CDA-YYK-YD CDS-YYS-YH CND-----FT

350 ....|....| ------ANP------AHR------GYP------GHP------GRP------GRP------GRP------GFP------GFP------GFP------GFP------GFP------GFP------GFP------GFP------GFP------GFP------GFP------GFE------GFE------GFP------GYT------GYT------GFP------GFP------GFP------GFP------GLP------GMP------GFP------GFP------GFP------GFP------GFP------GFP------GFP------GFA------GFA------GFP------GFPT ------GFPV ------GFPV ------GFP------GFP------GFP------GFP------GI-------GDP------GDP------GDP------GDP------GAP------GAP------GAP------GAP------GDP------EDS------GYK------GQG------GQG------GQG------GQG------GQG------PFQ------NS-------ET-------NS-------GS-------NS-------HT-------HS-------YT-------YT-------RS-------NS-------GS-------GS-------GR-------ESP------EN-------GA-------GH-------DNP------GM-------NM-ARSP--GEPD T-----TTP------GGGG ------PSEK ------PTEK ------RSSS ------PTAK RSSSSGGSTT ------DC--

360 ....|....| -------KLG -------ELN -------ELG -------ELA -------ELH -------ELP -------ELP -------DLD -------GLE -------DLE -------DLE -------DLE -------DLE -------NLE -------GSD -------RVE -------DVE -------GVE -------DVL -------DVL -------AVS -------DLE -------DLE -------NLE -------DLD -------NLE -------DLE -------DLD -------DLN -------KLE -------DLD -------DLE -------DLE -------DLD -------DLD -------DLD -------DYK -------DYK -------DHN -------ELD -------ELD -------ELD -------NLD -------GLE -------DLD -------DLD -------NVT -------KST -------KST -------KST -------KST -------KQT -------KQT -------KQT -------KQT -------KLK -------DTK -------DLD -------SLD -------TLD -------TLD -------TLD -------TLD -------DTK -------TER -------GWC -------RSE -------NSP -------DIP -------NSL -------NEF -------NDI -------NEG -------DYS -------AYP -------AWG -------SWP -------EHP -------EQP -------EYP -------DYP -------KYP --------WP -------IWP -------TWP -------ATK -------PVD -------DAP -------NRP -------NRP AAKKDGVDPA -------DAP AAAKD--DPT ----------

370 ....|....| VQ-IHFSWLF VQ-IHFSWFF IQ-IHFSWLF VQ-VHFSWLF VQ-IHFSWLF LQ-IHASWLF LQ-IHYSWLF LQ-IHNCWLF IQ-IHSCWLF IQ-IHNCWLF IQ-IHNCWLF IQ-IHNCWLF IQ-IHNCWLF LQ-VHNSWLF LQ-VHNSWLF LQ-VHNSWLF LQ-VHNSWLF LQ-VHNSWLF LQ-IHGSWLF LQ-IHGSWLF LQ-LHGSWLF LQ-VHASWLF LQ-VHASWLF VQ-VHNSWLF LQ-VHNSWLF IQ-VHNSWLF LQ-IHNSWLF LQ-VHNSWLF YQ-VHFSWLF ID-VHSCWFF LQ-IHFSWLF LQ-IHFSWLF LQ-IHFSWLF LQ-IHFSWLF LQ-IHFSWLF LQ-IHFSWLF LD-VHGSWIF LD-VHGSWIF LQ-VHGNWLF FK-VHFSWLF FK-VHFSWIF FK-VHFSWIF LQ-VHNCWLF LQ-VHSSWLF LQ-IHNSWLF LQ-VHNSWLF LE-MHGTWLT LQ-IHFNWLF LQ-IHFNWLF LQ-IHFNWLF LQ-IHFNWLF LQ-IHFNWLF LQ-IHFNWLF LQ-IHFNWLF LQ-IHFNWLF LQ-IHNCWHF LQ-IHNSWHF LQ-VHNSWLF LQ-IHNSWLF LQ-VHNSWLF IQ-IHKCWLF LQ-IHNSWLF LQ-VHNGWLF LN-IHRSWFF LH-IHRNWFF LTGGHRNWFF LQ-IHDSWLF LN-IHRSWLF LH-VHRSWLF LK-IHRSWMF LN-VHRSWFF LS-IHRSWLF LS-IHRSWFF LE-IHDGWFF LE-IHDGWFF LE-IHGGWFF LE-IHGGWFF LE-IHQNWLF LE-IHQNWLF LE-IHQTWLF LE-VHNGWFF LE-VHNGWFF LE-IHNGWFF LE-IHNHWLF LE-IHNHWLF FD-VHFSSIF FD-VHFSSVF FD-VHFSWVF FD-VHFSWIF FD-VHFSWIF FD-VHFSWIF FD-VHFSWIF FD-VHFSWIF ---KHSNWYF

380 ....|....| FTFHRAHLYF FAFHRAYLYF FPFHRAYLYF FPFHRAYLYF FPFHRAYLYF FPFHRAYLHF FPFHRAYLYF FPWHRLYVYF FPWHRMYLYF FPWH-----FPWHRLYLYF FQWHRFYLYF FPWHRFYLYF FPFHRYYLFF LPFHRCYLYF FPFHRCYLYF FPFHRCYLYF FPFHRCYLYF TPWHRYYIYF TPWHRYYIYF LPWHRYYIYF LPFHRYYLYF LPFHRYYLYF FPFHRYYIYF LPYHRYYLYF FPFHRYYLYF FPFHRYYLYF FPFHRYFLYF FPWHRYYLYF FPWHRYYLYF FPWHRLYLYY FPWHRAYLYY FPWHRLYLYY FPWHRLYLYY FPWHRLYLYY FPWHRLYLYY FPWHRWYLYF FPWHRWYLYF APFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPYHRWYLYF FPYHRWFLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYIYF LPWHRWYLYY LPWHRWYLYY LPWHRWYLYY LPWHRWYLYY LPWHRWYLYF LPWHRWYLYF LPWHRWYLYF LPWHRWYLYF FPWHRWYLYF YPWHRWYLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPFHRWYLYF FPWHRWFLYF FPWHRWFLYF LPWHRWYLYF FPWHRMLIYF FPWHRMMLYF FPWHRMMIYF FPWHRMYIYF FPWHRMLIYF FPWHRMMIYF FPWHRMFLYF FPWHRMFLYF FAWHRAFLYF FAWHRAFLYF LPWHRLYLYF LPWHRLYMYF LPWHRLYLYF LPWHRMFLYF LPWHRMFIYW FPWHRMFLYF LPWHRMFLYF LPWHRMFLYF APWHRMYIYF APWHRMYIYF APWHRMYLYF APWHRMYIYF APWHRMYIYF APWHRMYIYF APWHRMYIYF APWHRMYIYF APWHRSYLYY

390 ....|....| FERIAAKLLG FERIAAKLLG FERIAAKLLG FERIAGKLLG FERVAARLLG FERIAARLLG FERVAARLLG HERILGKLIG HERILGKLIG ---------HERILGKLIG HERILGKLVG HERILGKLIG FERILGKLID FERILGSLIG FERILGSLIG FERILGSLIG FERILGSLIG WEKILGKLLK WEKILGKLLK WEKILGKLID NERILAKLID NERILAKLID HEKILGSLIG YEKILGKLIN YEKILGKLID HERILGKLID HEKILGKLID YERILGKLIN YERILGKLIN FERILGKLID FERILGKLID FERILGKLID FERILGKLID FERILGKLID FERILGKLID YEKILGKMIG YEKILGKMID HERILGSLIG YERILGSLID YERILGSLID YERILGSLID YERILGNLIG YERILGSLIN YEKILGSLIN YERILGSLIN HERILASLLN HEKILGSLIN HEKILGSLIN HEKILGSLIN HEKILGSLIN HEKILGSLIG HEKILGSLIG HEKILGSLIG ---------G YERILGNLIG YERILGSLID YERILGSLID YERILGKLIG YERILGKLIG YERILGKLIG YERILGKLIG YERILGKLIG FERTLGKLIG HERILASLIE HERILASLIE HERILGKLLG HERILGSLIG HERILGSLIG HERILGSLIG HERILASLID HERILASLIE HERILASLID HERILASLIG HERILASLIG HERILASLIR HERILASLIG HERILAKLIG HERILAKLIG HERILAKLIG HERILGELLG HERILAKILD HERILAKLLD HERILAELLD HERILAKLLD FEGILGELVG YERIIGELTN YERILGDLIG YERALGDLIG YERALGQLIG YERALGQLIG YERALGQLIG YERALGDLIG FEQLIQHFSG

400 ....|....| EPEFALPFWS EPGFAVPFWS DPAFALPIWS DPGFAVPFWS DPGFAVPFWS DPGFAVPFWS DPGFAVPFWS DDSFALPFWN DETFALPFWN --SFALPFWN DDKFALPFWN DDKFALPFWN DDKFALPFWN DPTFAMPYWN DPSFAMPFWN DPSFAIPFWN DPSFAIPFWN DPGFAVPFWN DPTFAIPYWS DPTFAIPYWS DPTFAIPYWN DPTFALPYWA DPTFALPYWA DPTFALPYWN DPTFALPFWN DPTFALPFWN DPTFALPYWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN GPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPYWN DPTFALPYWN DPTFALPYWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DSSFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPSFALPFWS DPSFALPFWS DPSFALPFWS DPGFALPFWS DPTFGLPFWN DPTFGLPFWN DPTFVLPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPTFALPFWN DPNFALPFWN DDTFALPFWN DDTFALPFWN DDTFALPFWN DDTFALPFWP DDSFALPFWN DENFALPYWN DDTFSLSFWN DDTFSLSFWN DDTFSLSFWN DPTFALPFWN DPTFTLPFWN DHTFALPFWN DDSFSLLFWN DDEFAIPYWA DDEFALPYWN DDTFALPYWN DDTFALPYWN DETFALPYWN DDTFALPFWN DDSFALPYWN DDTFALPYWN DPAFGLPYWN DPAFALPYWN DDTFALPYWN DDTFALPYWG DDTFALPYWN DDTFALPFWS DDTFALPFWN DDTFALPFWN NATFALPYWD


410 ....|....| WDV---PE-G WDV---PE-G WDV---PE-G WDV---PE-G WDV---PE-G WDV---PE-G WDV---PE-G WDA---PG-G WDA---PD-G WDA---PA-G WDA---PG-G WDA---PG-G WDA---PG-G YDS---PA-G WDA---PG-G WDA---PD-G WDA---PD-G WDA---PD-G WDT---PE-G WDT---PE-G YDQ---PS-G WDN---PD-G WDN---PD-G WDA---PG-G WDA---PA-G WDS---PG-G WDS---PE-G WDS---PA-G WDS---PQ-G WDS---PS-G WDA---PA-G WDA---PA-G WDA---PA-G WDA---PA-G WDA---PA-G WDA---PA-G WDN---PA-G WDN---PA-G WDN---PP-G WDN---PDGG WDN---PDGG WDN---PDGG WDN---PKGG WDA---PK-G WDA---PD-G WDA---PK-G WDSMMEPERP WDN---QDGG WDN---QDGG WDN---QDGG WDN---QDGG WDQ---EG-G WDQ---EG-G WDQ---EG-G WDQ---EG-G WDN---PA-G WDN---PP-G WDN---PK-G WDN---PK-G WDN---PK-G WDN---PK-G WDN---PK-G WDN---PK-G WDS---VE-G WDN---QS-A WDN---QF-A WDN---QAAG WDI---PE-G WDN---PD-G WDS---PD-G WDT---PA-G WDA---PE-G WDA---PE-G WDN---QSQG WDN---QS-P WDN---QL-P WDN---QSPG WDN---QS-P WDN---QS-P WDN---QDST WDN---PE-A WDN---QS-P WDN---QT-P WDN---QS-E WDN---QS-S WDA---PA-G WDS---PD-G WDA---PA-G WDT---PA-G WDA---PA-G WDH---PA-G WDT---PA-G WDH---PA-G WSQ---TH--

420 ....|....| -----MRMPV -----MRMPV -----MGIPE -----MRMPL -----MRVPP -----MRVPQ -----MRVPP -----MTLPA -----MSFPA -----MALPS -----MSLPA -----MSLPA -----MSMPA -----MTIPA -----MRMPA -----MRMPA -----MRMPA -----MRMPA -----MYMPG -----MYMPG -----MRFPD -----MYMPT -----MYMPA -----MRMPT -----MQMPA -----MQLPA -----MQLPA -----MQLPA -----MQIPA -----MQMPY -----MQMPA -----MQIPA -----MQMPA -----MQMPA -----MQMPA -----MQMPA -----MRIPP -----MRIPP -----MAMPA -----MVIPL -----MVLPS -----MVLPS -----MTIPS -----MQLPS -----MQLPS -----MQLPS -----SQIPE -----SYIPE -----SYIPE -----SYIPE -----SYIPE -----RYIPD -----RYIPD -----RYIPD -----RYIPD -----MVMPE -----MVMPD -----MQMPK -----MTIPP -----MTIPP -----MTIPP -----MTMPP -----MTIPP -----MQIPS SDPLPNVIPQ SDPLPNVIPQ -SPLANVIPS -----MVIPE -----MVIPE -----MFIPD -----MVMPD -----MVTPD -----MLTPE -ATQGNVMPR IAPLGNLVPR IEPLGNIIPC -AVQGNVMPS IPPFPGEIPK VAPYPGAVPR ----QNPLPN TEPLPNAIPS EPPFGNTIPE EEPYANVLPI EEV-ANTLPD SEE-ANILPR -----MMLPA -----MSLPA -----MALPD -----MGIPA -----MGIPA -----MVVPA -----MVVPP -----MVVPP ------TVPS

430 ....|....| EFA----N-EFA----N-VFT----D-QFA----N-EFA----D-EFA----D-EFA----D-IYS----S-MYA----N-IYN------IYA----N-IYA----D-IYA----N-MYT----N-MYV----D-MYA----D-MYA----D-MYA----D-MYL----D-MYL----D-IYK----N-IYA----S-IYA----S-LYA----D-MFA----D-MYA----D-LYA----N-IYV----D-FFA----D-IFT----D-IFT----D-IFT----D-IFT----D-IFT----D-IFT----D-IFT----D-IFT----D-IFT----D-IYT----D-IYR----D-IFA----D-IFA----D-FYV----D-IYA----D-IYA----D-IYA----D-YFY------MFR----R-MFR----R-MFR----R-MFR----R-MFR----R-MFR----R-MFR----R-MFR----R-RFA----V-MFA----V-IFD----N-MFL----D-MFV----D-MFV---ED-MFV----D-AFI----D-YFN----N-MYL------MYL------AYL----N-MYM------MYV------MYL------MYF------MYF------MYF------YYS----E-YMS----E-YFD--EVD-FFD----D-AFA---HEWS VYD---LEWS IFP----K-FYW----N-IYA----N-SYA----K-IYA----S-IYS----T-AFT----N-IFA----N-IFK----D-VFK---GD-IFKQGVST-LFK---GS-LFK----D-LFR----DAG SFY---GD--

440 ....|....| --------SS --A-----SS --E-----AS --A-----SS --A-----AS --E-----VS --A-----AS --A-----SS --R-----WS -----------K-----SS --K-----SS --K-----TS --P-----SS --P-----KS --------QS --P-----SS --R-----SS --R-----NS --R-----NS --S--PKDQN --------SP --------SP --------SN --P-----NS --P-----NS --P-----KS --P-----KS --P-----KS --P-----KS --P-----KS --P-----KS --P-----ES --P-----KS --P-----ES --P-----ES --K-----SS --K-----SS --E-----NS --E-----DS --E-----DS --E-----DS --K-----NS --P-----KS --P-----KS --P-----KS --------TM --E-----GT --E-----GT --E-----GT --E-----GT --------ET --------ET --------EI --------ET --Q-----DS --T-----TS --S-----GS --E-----KS --P-----KA --P-----RS --P-----KS --P-----KS --P-----NS --------TN --------TN --------QA --------KA --------TG --------NG --------QE --------KE --------EE --RRWSNKSN --AYWNRRPN --------NN --PI----DN LSPNAINKTS LSPDAINKTS --------TS --P-----NS --P-----KS --S-----GS --N-----RS --N-----ET --P-----DS --P-----AS --A-----GS --D-----DN --A-----DN --F-----VN ------SMGN --AAGSTASN --------AN

450 ....|....| SVLYD--PIR P-LYD--PVR P-LYD--PIR P-LYD--QMR P-LYD--PIR P-LHD--PSR P-LYD--PMR P-LYD--ERR P-LYD--PRR ---------P-LYD--ERR P-LYD--ERR P-LYD--ERR P-LYD--KLR P-LFD--PRR SQLFD--PRR Q-LFD--PRR Q-LFD--PRR P-LYD--DNR P-LYD--DNR P-LFD--CIR SSLYD--EKR SSLYD--EKR SALYD--PLR P-LYD--KLR P-LYD--SLR P-LYD--HYR P-LYD--QFR A-VYD--PLR P-LYD--QFR P-LYD--PLR P-LYD--PLR P-LYD--PLR P-LYD--PLR P-LYD--PLR P-LYD--PLR P-LYD--EHR P-LYD--EHR P-LYD--PFR P-LYD--PRR P-LYD--PRR P-LYD--PRR P-LYD--PLR P-LYD--PLR P-LYD--TLR P-LYD--TLR PALVD--PLR P-IFD--ANR P-IFD--ANR P-IFD--ANR P-IFD--ANR A-LCD--AKR A-LYD--AKR A-LYD--KKR A-LYD--AKR P-LFN--PRR P-LYD--ARR P-LYD--ANR A-IYN--SKR A-IYD--AKR A-LYD--RKR S-LYD--KKR A-LYD--AKR S-LYH--QLR PVLFD--DFR PVLFD--DFR P-LID--SLR P-FFH--EAR S-LVD--TDR S-MID--TER P-FLD--TER P-FID--TER P-FID--IER P-LYD--PNR P-LYN--RNR P-LYS--PNR P-LYN--ANR S-LYD--PDR S-LYD--ADR P-LFD--PLR S-LYD--PNR P-LYD--VNR P-LWN--QQR SSLWN--HNR SYLRD--LNR P-LYD--ANR P-LYD--AKR P-LYD--AKR P-LFD--PYR P-LYD--PYR P-LCN--PNR P-LYD--PNR P-LYD--ANR P-LDDNISIQ

460 ....|....| NPS--HA-PP NPR--HA-PP EPS--HA-PP NPW--HA-PP NPE--HA-PP NPR--HA-PP NPD--HA-PP NTA--HQ-PP NQA--HL-PP --------PP DPA--HQ-PP DPA--HQ-PP DPA--HQ-PP NQG--HQ-PP DAR--HA-PP DGR--HA-PP NSR--HA-PP DSR--HA-PP NHN--HF--T NHN--HF--T NPE--HL-NG NAK--HL-PP NAK--HL-PP DAK--HQ-PP DAK--HQ-PP NKN--HQ-PP NKN--HQ-PP NKN--HQ-PP DKS--HQ-PP DQN--HQ-PP DAN--HQ-PP DAN--HQ-PP DAN--HQ-PP DAN--HQ-PP DAN--HQ-PP DAN--HQ-PP NSD--HV-NA NSD--HV-NA NAL--HQ-PP NPD--IT-PD NPD--IT-PT NPD--IT-PT NLN--HQ-PP NAN--HQ-PP NAN--HQ-PP NAN--HQ-PP NPR--HR-TP NEA--NY-AP NEA--NY-AP NEA--NY-AP NEA--NY-AP NTS--HY-EP DTS--HY-EP DTS--HY--D NTS--HY-EP NQT--HL-PP NLE--HL-PP NQK--NR-PP NQD--NL--K NPA--NM-PP NQK--NL--R NQE--HL-PP NPD--NM-PP NQN--HL-PP NPD--HF-PP NPD--HF-PP NQQ--HL-PP DFS--HF-PP ENS--HL-PP DNS--HL-PP SDK--HIHRP SET--HVRRP SDN--HVRRP NRC--AL-PP NRC--AL-PP AQC--AR-PP DQC--AR-PP NSC--SK-NP NNC--SK-PP NACATQSVPP NIC--SR-PP NNC--SV-PP NKC--AE-PP NKC--AQ-QP NKC--AQ-PP KPE--NE-RG NQE--NV--K NPA--NL--G NMD--N--ND NME--NM-DA NMA--NV-DA NPS--NV--D NPA--NL--D SIC--SS-AP

470 ....|....| KLVDL--DFKVVDL--EFKVADLDFSYKLVDL--DYRVVDL--DFRVVDL--DFRLVDL--DFSFLGL--DFFPLDL--DYFLLGL--HYFTVDL--DYFTLDL--DYFTLDL--DYALIDL--NFELINL--DYKLIDL--DYKLINL--DYKLINL--DYALMDY--DFALMDY--DFALMDY--RYTVIDL--DYTVIDL--DYVMVDL--DYKLIDL--DYTLLDL--DWTLVDL--DYTLVDL--DYKIIDL--DFILLDL--DYILLDL--NYTLFDL--NYTLLDL--NYTLLDL--NYTLLDL--NYTLLDL--NY-FIDL--DY-FIDL--DYVIVDLANEATLVDL--NYTLVDL--NYTLVDL--NYVLIDL--DYTLVDF--DFTLVDL--DFTLVDL--DFAVPDLSTDLARVDL--GYARVDL--GYARVDL--GYARVDL--GYTRVDL--IYTRVDL--FYTRVDL--IYTRVDL--IYTPTDL--AYAAADL--NFAIIDL--GFAIVDL--GMAVVDL--GLAVVDL--GLAVVDL--GLAVVDL--GFHVVDL--NYRLADL--NFRLADL--NFRLVDL--NYS SVVDL--DYQVVDL--NYN QVADI--NYD RVVNL--DYKVADI--NYKVADINYNYHLIDL--NSFLIDL--NSNIVDL--AYT NVVDL--GYI QIVEF--QNRLPEF--HNRLVEF--QDFIVDL--DSFVVDM--DTLIIDL--NTNIVNL--NTNLVHL--NSAFIDL--SLSTIDL--NLAYLNL--HIALIDL--DYL-LDL--DYL-VDL--DYALVDL--DYALIDL--DY----------

480 ....|....| ----LGPEK---VRSSVD---RLEKNL---AMDVVE---SKVDKNY SYAEKNCTDSYVDRNCTD----SDTDP----SGTDTN ----SGTDD-----DRIE----DGTEP----DGTEPT ----SGSGT----NGREP----NGSER----NGREPR ----NANVR---TWGAPN---TWGAPN---EFGDPS----DGTES----DGTEPT ----DLIDP----NLTDS----SGTDT---NRTENP----NGSEN----PGVDF---GAGYPN---ATGDAN---ATGDAN---AKGDAN---AKGDAN---AKGDAN---AKGDAN---KKDDSP---KKDHSP----NILDP---GSGKDP---GSGKEP---GSGKEP-NRRDDDDP----NLDNP----NLEDP----NLEDP----TGRSP---APGVDPS ---APGVDPS ---APGVDPS ---ASEVDP---SPGSDD---SPGSDK---SGSDGK---SLGSDK----SAKSP----ASKPT---SGATED---TGNKDP---TGNKDP---TDATDT---TNSTDT---TGSTDP---NKLDPN---VPGDGA---VPGDGAGQ-DSGPIP---SCTTPSS LQ-EKGLGPYV-ESGLGP-N-LVEINRNFVESNLKP---VDDFNL---GGGCSGM ---GVGCVRGAGLNGECPSQ-TPGGPC---FTACPL---FTACEP---VVGIPCI ---IGGCTN---RTGCTN---IGGCTA---VGGCT----IGGCT----SPKVKS---GPGKQND ---AKAGDT---LKTPRR---LKKPRR---LSHKDD---LNDRNA---LNDKDN---TAGRGR-

490 ....|....| -------NFT -------DKF -------TD-------NNY -------TD-------------------------DDM I------PK-------DAS -------QNI -------TIP I------PR-------ITA -------TFT -------RFT FF-----TD-------EP-------PT-------PT-------PT-------TIP I------PD-------QIS -------NDT -------PTS -------TSN -------PTS -------PLP -------PTN -------PD-------PD-------PD-------PD-------PD-------PD-------VK-------VK-------------------------------------------SAS -------IS-------IS-------IS-------MDI FGEPTYKTDFGEPTYKTDFGEPTYKTD-------KSK -------KSD -------KSD -------SD-------KSD -------TN-------TD-------------------------------------------------------------DDT -------PIS -------PIS -------PD-------EDY -------------------------TS----------------KP-------PD-------MSS -------DM-------PDS -------PQN -------QNL -------PKN -------KTA -------KTS -------KSP -------EKT -------DKT -------DPN LPLCSSTEDG -------TVI -------PTV -------DTI -------KPI -------EPI -------EPI -------PD-

500 ....|....| D--------TD----------------TD----------------------------------PR----------------GISR-----PR-------R--------------------------D--------D-----------------R-FTY----PEQE-----PEQE-----PEQE-----D-----------------E--------N--------N-----------------K--------D--------A--------PAKA-----PAKA-----PAKA-----PAKA-----PAKA-----PAKA-----PPQTILWPPV PPQTIIWPPV ------------------------------------ESVDP-------------------------------KNATL-------------------------------PNKPD----------------------------------------P--------P--------------------------------------------------------------PS-------D--------D-----------------RCFESGLGP------------------------------------------------------A--------------------------K-----------------P-----------------------------------P--------A--------KFKDDL---D--------PFDPQAAHLN PFTPPPVSDA PFEPP--TDP DFKGP----PFKGPRDEKY PFSG---------------


510 ....|....| --------EQ --------EQ --------EQ --------DE --------EQ --------EQ --------EQ --------DL --------DQ --------DN --------AQ --------AQ --------HQ --------EQ --------RQ --------NQ --------KQ --------KQ --------EE --------EE --------ES --------DE --------DE --------QE --------EQ --------EE --------QA --------QE --------PV --------NQ --------EE --------EE --------EE --------GE --------EE --------GE EKKNNSIVDN VKKNNSIVDN --------SK -----------------------------------NE --------NG --------NG --------NG --------EE --------DQ --------DQ --------DQ --------DQ --------EQ --------EQ --------EQ --------EQ --------KK --------SK --------LQ --------LQ --------LQ --------LQ --------LQ --------LQ --------HQ --------SK --------SK --------ST --------ED --------EE --------ED --------EE --------EE --------DE --------DY --------RS --------EG --------LG --------SA --------TL --------EA --------DF --------DF --------SV --------TE --------DE --------LG --------SC --------NQ AARQAY--DD AARAKY--DD -KDEKY--KD --------KE --PKDEEYKK --------GE

520 ....|....| QIQHNLRVMY QIQQNLRVMY QILHNLRVMY QIKHNLWIMY QIQLNLRTMY QIQLNLRIMY QIQLNLRIMY QVDQNLKVMY LIDQNLNIMY QIDENLRIMY QIDQNLMIMY QIDQNLMIMY QIDQNLMIMY QVKRNLTVMY QVDHNLRVMY QIDRNLRVMY QVDHNLRVMY QVDHNLRVMY VKIRNLKKIH VKIRNLKKIH VILENQKYLY LKTDNLAIMY LKADNLAIMY QININLSIMY QISSNLSIMY QLSSNLTIMY QISSNLTIMY LLSSNLTIMY QVASNLNVMY LYSSNLTVMY LYASNLNVMY LYASNLNVMY LYASNLNVMY LYASNLNVMY LYASNLNVMY LYASNLNVMY LIVNNLIKVY LIVNNLIKVY QIVNNEITMF SVEQNLGVMY SVEQNLGVMY SVEQNLGVMY QIASNLSIMY RISTNLTIMY KISNNLTIMY KISNNLTIMY VIESNNNLLY IRQDNISVMY IRQDNISVMY IRQDNISVMY IRQDNISIMY IREDNLSIMY IREDNLSIMY IREDNLSIMY IREDKLSVMY IIPNNLTIMY IVTNNLTTMY VVVNNLTVMY VVSNNLTVMY VVSNNLTVMY VVSNNLTIMH VVANNLTIMY VVSNNLTIMY QVSYNLAFMY QREENNALMY QREENNALMY QRAENNALMF QVHTNLVMMY QIKINMALMY QISTNIAFMY QISHNLAVMY QISKNLAFMY QISKNLAFMY LRTENNRLMY ILTENNRLMY LQDSNGEIMR LDTYNNDIMR VREQNAQLMW AREQNAQLMW VRLENAHLLW LRVQNTRLQY LRVQNTRLTY LRTENDRIMY LRIENTRLMY LRIENTQVMY LIDSNLCAMY VKAANLCTVY VVQNNLATLY AVRTNLATVY AVQTNLCTIY LVNRNLCTIY LVNKNLCTVY LVNKNLCTVY EITQQELEEY

530 ....|....| KQ------MI KQ------MI KQVLDPSAMI KQ------MI KQ------MV KQ------MV KQ------MV RQ------MI RQ------MI RQ------MV RQ------MI RQ------MI RQ------MI RQ------MV RQ------MV RQ------MV RQ------MV RQ------MV NM------FT NM------FT NM------FA KQ------IV KQ------IV RS------VV RQ------IV RQ------MV RQ------MI RQ------MV RQ------VV KQ------MV RQ------MV RQ------MV RQ------MV RQ------MV RQ------MV RQ------MV TA------VA TA------VA RH------VV TS------VV TS------VV TS------VV RN------VI RQ------LV RQ------VV RQ------VV QT------VV NN------VA NN------VA NN------VA NN------VA NN------VA NN------VA NN------VA NN------VA GE------MV GE------MV SE------MI SE------MI SE------MV NE------MI SE------MI TE------MV KQ------MV KQ------LV KQ------LV QQ------IV NQ------MV TQ------MV NQ------MV HQ------VV HQ------MV HQ------MV NQ------MV TQ------MV LQ------MS LQ------MA TQ------AV TQ------AV TQ------FL TQ------MV SQ------IV TQ------VV TQ------IV TQ------IV RQ------MN RQ------MA VQ------MM IQ------QI LQ------QV TQ------QV TQ------QI TQ------QV VG--------

540 ....|....| GN-AALPSLF SN-AALPSLF SG-AALPSLF SS-APLASLF TN-APLPSLF TN-APLPSLF TN-APLPSLF SG-AKRRELF SG-ARKAELF SN-AKKPQLF SG-AKKKELF SG-AKKKELF SG-AKKKELF SN-SKTPRLF SL-SPTPSLF SL-SPTPSLF SL-SPTPSLF SL-SPTPSLF ET-IGAPSLF ET-IGAPSLF EN-LFNPGNF SG-ATTPKLF SG-ATTPKLF SN-GKTAQLF SS-AKTTSLF SN-GKTPRLF SN-GKTAKLF SN-GKTARLF T--AKYPTLF SG-AAKPTLF SG-ATKPTLF SG-ATKPTLF SG-ATKPTLF SG-ATKPTLF SG-ATKPTLF SG-ATKPTLF SKTNSSPDYF SKTNSSPDSF IE-GISPSLF SG-AKRASLF SG-AKRASLF SG-AKRASLF SN-GKLPRLF SN-GKTPTLF SN-GKTPTLF SN-GKTPTLF SG-ATLPSLF K--VKLQDAF K--VKLQDAF K--VKLQDAF K--VNNQEAF K--VKQPDAF K--VKQPDAF K--VKQPDAF K--VKQPDAF RN-VKKLEDF RN-VSKLEDF RS-VNSTLDF RG-NADVYDF RA-NSDIYDF RG-ISDPLDF RG-NSDANDF RG-NSDVYDF L--ASTKELF N--ARTTRLF N--ARTTRLF SG-SRTPSLF AG-AKKMELF SG-AKTTELF SG-AKKTELF SG-AKKMELF SG-AKKVELF SG-AKKVELF SG-PTTPSLF SG-ATTPSLF ---AETARLF ---AETARLF SV-SVTPLIM SV-SVTPLIM SG-GPTPLTF LG-GDTPALF LG-GGTPSLF SG-AMSPQLF SG-APTPRLF TG-APTPRLF ---VKEPVDF ---VDTAAQF R--NKKAQDF RD-GKGPRAF RD-GKGPRAF R---KGPESF RS-GKGAESF RK-GAES--F ---PVRIESI

550 ....|....| HGQ------P HGQ------P MGQ------P HGQ------P YGQ------P HGQ------P HGQ------P MGQ------P MGQ------P LGQ------P FGL------P FGM------P FGL------P FGS------A FGG------A FGG------A FGS------A FGS------A LGG------P LGG------P MGQ------P LGY------P FGY------P LGS------P MGA------A FGG------A MGS------S HGS------A MGR------P FGK------S FGK------P FGK------P FGK------P FGK------P FGK------P FGK------P LGP------A LGP------A LGK------P HGK------A HGK------P HGK------P LGS------P LGN------P LGN------P LGN------P LGK------P FGA------P FGA------P FGA------P FGA------P FGH------P FGY------P FGY------P FGY------P YGA------K YGA------K MGQ------P MGQ------P MGK------P MGA------R MGQ------A MGK------A MGS------P YGK------E YGK------E FGQ------A MGC------P MGC------P MGC------P MGC------I MGC------T MGC------T FGS------T HGS------T HGN------P HGA------P AGA------P SGA------P HGA------P YGM------P YGL------P YGM------P FGQ------A FGE------P HGG-----YP HGD------R LGG------K LGE------K LGEKLCSESS LGE------K LGE------K LGE------K QQN------P

560 ....|....| YRAGQ--NDYRAGE--SDYRAGD--AAFRAGE--ASYRAGD--REYRAGD--RGYRAGD--RAYRAGD--AAYRAGD--QPYRAGD--DAYHQGD--QPYRQGD--QPYHQGD--QPYRRGE--DPYRAGD--EPYRAGD--DPYRAGD--EPYRAGD--DPLSAGQ--VPLSAGQ--VPISEGQ--TLYRAGD--AIYRAGD--AIYRAGD--EPYRAGD--EPYRAGD--EPYRAGD--EPYRAGD--EAYRAGD--EPYRAGE--DTYRAGD--DPYRAGD--DPYRAGD--DPYRAGD--DPYRAGD--DPYRAGD--DPFEAGS--APFEVGS--DPYYAGC--EPFFAGK--QPFLAGK--QPFLAGK--QPYRAGD--EPYRAGD--APYRAGD--EPYRAGD--EPLRGGV--EKIRKGN--NNIRKGN--NNIRKGN--NNVRKGN--NNIRKGS--GSLRKGS--SSIRKGS--SSLRKGS--SSYVVGT--KPYVVGT--APYKAGD--AAYREGT--AVYREGT--LVYSEGS--DPYREGD--ESYREGT--PVFRLGD--NPYHPGD--SKYHPGD--SKYRAGD--ANYKAGE--GGYKGGE--GGYKAGE--LGYKSGI--NGYKPGT--NNYKRGT--TGYRFGW--SGYRFRW--MGYRYNT--RGVRYNT--RGYRFGD--DGYRFGD--YGYRFGD--YGYRLGD--FGYRKGD--FGYRYGD--AGYSYGD--GGYSYGD--SGSRTTK--PPFCAAG--VKFCSSY--PGT LCSEA--SSR FRVKEINERS YCTAI--EGYCTDI--GSYCTDL--GSDYATY--GG-

570 ....|....| ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKEVNERSKR KRRQADGQSS -------------------------------------

580 ....|....| --MP-------RP-------KP-------KP-------MP-------MP-------MP-------DP-------EP-------DP-------DP-------DP-------DP-------NP-------DQ-------NQ-------NQ-------NQ-------QD-------QD-------N--------DP-------DP-------DP-------DP-------GP-------DP-------DP-------EP-------SP-------SP-------SP-------SP-------SP-------SP-------SP-------QQ-------KK------NNP-------EL-------EL-------EL-------EP-------DP-------DP-------DP------TSL-------G--------G--------G--------G--------KN-------IN-------VN-------IN-------DP-------DP-------SP-------NP-------NP-------NP------SAK-------NP-------TP-------PD-------PD-------AP------SCN------FCE------FCD------SCD------SCD------FCN-------GM-------GM-------GR-------GR-------GM-------GM-------GV-------GG-------GA-------GH-------GH-------GY------------------------RSSG----RQGAGAPKVK KVSPSKSQ---RG------STS------STS-------IG------

590 ....|....| ---GAGTVEL ---GAGTVEL ---GAGTVEL ---GAGTVEL ---GAGTVEL ---GAGTVEL ---GAGTVEL ---GAGTVEN ---GAGTVES ---GAGSIEN ---GAGTVES ---GAGTVES ---GAGSVEL ---GSGSVEN ---GPGPMEN ---GPGPVEN ---GPGPVEN ---GPGPVES ---IAGALEN ---IAGALEN ---APGTLEN ---GAGTLEH ---GAGTLEL ---GPGSFEN ---GQGTLEN ---EPGPIEN ---GAGSIEN ---GAGSIEN ---GAGSLED ---GAGTIET ---GMGTIET ---GMGTIET ---GMGTIET ---GMGTIET ---GMGTIET ---GMGTIET ---HFGSLES ---HFGSLES ---GAGSLEK ---GGGTVEL ---GGGTVEL ---GGGTVEL ---GAGSLEN ---GGGSVEG ---GFGSVEN ---GFGSVEN ---GASAFEV ---GDGSLEK ---GDGSLEK ---GDGSLEK ---GDGSLEK ---GPGGVER ---GPGGVER ---GPGGVER ---GPGGVER ---GPGSVER ---GPGTVER ---GMGSSER ---GPGSSER ---GPGASER ---GEGSVER ---AAGSSER ---GPGSSER ---GMGSIEA ---GLGTIES ---GLGTIES ---GGGTIEN ---GPGTIEL ---GPGTIEL ---GPGTIEL ---GAGTVEQ ---GPGTVEL ---GPGTIEV ---GGGTLEG ---GGGTLEG ---SPGNMER ---SPGNVER ---GMGGIEG ---GIGGIEG ---GMGTLEA ---GPGTFED ---GSGVFED ---GPGTFED ---GPGTFED ---GPGTFED ----VGSLET ---APGSLEN ---TSGSLES ASNAQGTLER ---SQGTLER ---SAGTLES ---SMGSLER ---SMGSLER ---GSGELEV

600 ....|....| APHNTVHTWT FPHNTMHTWT APHNSMHTWT QPHNLMHVWV SPHNTIHVWA WLHNIVHRWT SPHNVIHRWS VPHGPLHVWV VPHNPVHRWT VPHGIVHFWT VPHGPVHFWS IPHNPVHFWS IPHNTVHFWS IPHGPVHVWT IPHGPVHIWC IPHGPVHIWC IPHGPVHIWC IPHGPVHIWC Q-HGLPHQWT Q-HGLPHQWT L-HAIPHRFA VPHNIVHKWT VPHNIVHKWT VPHGTVHLWA IPHGPVHIWC IPHGPVHIWT IPHGPVHIWT IPHGPVHVWC VPHTTVHIWT TPHNNIHRWT TPHTEIHFWT TPHTQIHIWT TPHTQIHYWT TPHTQIHYWT TPHTQIHYWT TPHTQIHYWT L-HNTVHSWT L-HNTVHSWT GPHNNVHRWT GPHTALHRWT GPHTAVHRWT GPHTAVHRWT VPHGPVHSWT VPHGPVHLWT VPHGSVHLWT VPHGPVHLWT GPHGAIHGWV APHTAVHVFG APHTAVHVFG APHTAVHIFG TPHTAVHIFG APHNAVHIFG APHNAMHIFC APHNALHIFC APHNAVHIFC GSHTAMHAWV GSHTALHVWV GSHVAAHVWV GSHTAIHVFV GSHVAIHVFV GSHTSIHAWV GSHTSVHAWV GSHTAIHAFV APHNTVHTWV APHNTVHKWT APHNTVHKWT APHGTVHVWT APHNTVHKWV APHNTLHDWT APHNALHTWV APHDSLHGWV APHNALHSWV APHNALHGWV APHGTVHIFT APHGTVHIFT TPHGNVHVFA TPHGNVHIFT RPHGPVHVWT RPHGPVHLWV RPHGPVHIWT QPHGTIHAWV QPHGTIHAWV NPHGTVHLWV NPHGTVHLWV NPHGTVHLWV GAHTAAHIWV AAHTAVHIWT MAHTSVHVWT MAHTTVHVWA MAHTTVHVWT MAHTAMHVWV MAHTAVHVWV MAHTAVHVWV IPHNFIHRWV


610 ....|....| GD-----ITGD-----LAGD-----NSGDL----LSGD-----LSGD-----LSGD-----LSGD-----PTGD-----PRGD-----PRGD-----PSGD-----PRGD-----PRGD-----PTGD-----PNGD-----PSGD-----PNGD-----PNGP-----EAGP-----EASQ-----VEGL-----ADGL-----ADGD-----RTGD-----RTGD-----NTGD-----NTGD-----NTGD-----ADGD-----PTGD-----PNGD-----PNGD-----PNGD-----PNGD-----PNGD-----PNGE-----REGE-----LEGD-----PTGD-----PRGD-----PRGD-----PRGD-----KRGD-----INGD-----INGD-----INGD-----PAGS-----PNGS-----PNGS-----PNGS-----PKGS-----PYGS-----PNGS-----PKGS-----PDGE-----NTGE------NGD-----PRGD-----PRGD-----PRGD-----PEGDF----KDGDY----KNGA-----ADGS-----SGGS-----SAGS-----AAGS-----NLGT-----GLGS-----NLGK-----ESGK-----ESGK-----DSGN-----PYS GN-----PYA GD-----PLGD-----PSNT-------NE-------NV-------GDPNAEAPFGSVDPLPGRGN-----PDGD-----PDGD-----PDGE-------GD-----PLGD-----PGGRSSPKAPAT GRAN---PAT GK-----PTT GK-----AGP GK-----AGP GD-----VG-

620 ....|....| ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R--------K-----------------------------------------------------------------------------------------------------------------------------CTVDGGGVVA CSAEQGGVVG KPCDASTGGV TPSSEACSAA TPATATCSEA ----------

630 ....|....| ---LP---N---RP---S---RP---N---YP---N---QP---N---RP---N---RA---N---QP---N---QP---N---EA---N---QP---N---QP---N---QP---N---QP---N---QP---A---QP---S---QP---H---QP---D---IP-------IP-------RP-------KP-------KP-------QP---N---QP---N---QP---N---QP---N---QP---N---QP---N---QE---N---QT---N---QT---K---QT---N---QT---N---QT---N---QT---N---NN-------KP-------QP---H---QP---N---QP---N---QP---N---EP---N---QP---N---QP---N---QP---N---QP---N---NP---N---NP---N---NP---N---NP---N---QP---N---QP---N---EP---G---EH---N---AS-------TP---T---NK---Y---EP---S---EP---S---QP---S---QP---S---QP---A---KP---H---KP---H---KP---H---AP---N---NP---GS ---NP---G---NT---E---NR---Y---NR---Y---NP---Y---NP-------NP-------ADLRLNP ---ANTRVNP ------------------------------RP-------RP-------SE---SG ---AP---NK ---AA---TA ------------SA---NA ---SS---TT HDGKP---HC HDGKP---HC LSHKDGAFNC TGGFP---NH SGGVP---NH ---GK-----

640 ....|....| --------VE --------VE --------AE --------AE --------HE --------HE --------HE --------GE --------GE --------QE --------NE --------GE --------GE --------GE --------GE --------RE --------GE --------GE --------RH --------YH --------RW --------SE --------SE --------NE --------IE --------SE --------LE --------LE --------RE --------NE --------GE --------GE --------GE --------GE --------GE --------GE --------HH --------NH --------RI --------KE --------KE --------KE --------RE --------IE --------IE --------IE --------GE --------GE --------GE --------GE --------GE --------FE --------NE --------YE --------NE --------GE --------GE --------SE --------GE --------GE --------GE --------GE --------GE --------HE --------FE --------FE --------RE --------RE --------RE --------RE --------LE --------LE --------LE --------YD --------YD DTQQKYAAYD LTLKPYAVRD ---------K ---------K ---------I --------FD --------GD M-------FD --------FD --------FN -----------------GE GHDGQKHSLA --------NN --------QV --------NN TKGG-YSCNN SKGGVYSCNN --------NS

650 ....|....| NMGDYYSAGR NMGVYYSAGR NMGVYYSAGR DMGAYYAAGR NMGTYYSAAR DMGAYYSSAR NMGAYYSAAR DMGNFYSAAR DMGIFYSAAR DMGNFYSAAR DMGNFYSAAR DMGNFYSAAR DMGNFYSAAR NMGNFYSAGR DMGNFYSAGR DMGNFYSAGS DMGNFYSAGF DMGNFYSAGF DMGNFYTAAR DMGNFYTAAR HMGNFHTAAR DMGNFYTAGR DMGNFYTAGR NMGNFYSAGR DMGNFYSAAR DMGNFYSAAR NMGNFYSAGR DMGNFYSAAR NMGVFYAAAR DMGNFYSAAR NMGNFYSAGR NMGNFYSAGR NMGNFYSAGR NMGNFYSAGR NMGNFYSAGR NMGNFYSAGR DMGLLATAAK DMGLLATAAR DMGYLAWAAR DMGRFYSAGR DMGRFYSAGR DMGRFYSAGR NMGIFYSAAR NMGDFYSAAR DMGTFYSAAR NMGTFYSAAR DMVHLYSAAR DLGNFYSAGK DLGNFYSAGK DLGNFYSAGK DLGNFYSAGK DMGNFYSAGR DMGNFYSAGK DMGNFYSAGR DMGNFYSAGR DMGNFYSTGR DMGNFYSAGR DMGNFYSAGR DLGNFYSAGR DLGNFYSAGR DLGNFYSAGR DMGNFYSAGR DMGNFYSAGR DMGAFYTAAR DMGVFYSAAR DMGVFYSAAR DMGTLYSAAR DMGVFYSAAR DMGSFYSAGR DLGAFYSAAR HMGVFYAAAR NMGVFYAAAR NMGSFHSAAR DMGNLNVAAL DMGNLNVAAL DMGNLNRAAY DMGNLNRAAV DMGTFKDSAA DMGVFKDSAS KMSTNKDSAS DMGNFGRSAF DMGNFGRSAF DMGNFGRAAR DMGNFGRAAR DMGNFGRSAR HMGNLKTAAR DMGVLGTAAR DMGFLATAAR DMGFLGTAGR DMGFLGTAGR DMGFLGTAGN DMGFLGSAGH DMGFLGTAGR NMVQFFSPL-

660 ....|....| DPIFYPHHNN DPIFYPHHNN DPLFYPHHGN DPIFYTHHAN DPIFFPHHTN DPIFYPHHAN DPIFYPHHAN DPVFFAHHGN DPVFFAHHGN DPVFFAHHAN DPLFFAHHGN DPLFFAHHGN DPLFFAHHGN DPIFYAHHSN DPLFYAHHGN DPLFYAHHAN DPLFYAHHAN DPLFYAHHAN DTMFFGHHAN DTIFFGHHAN DPVFYAHHAQ DPIFFGHHAN DPIFFGHHAN DPIFFCHHSN DPIFFSHHSN DPIFFCHHSN DPIFFAHHSN DPIFFAHHSN DPIFFAHHGN DPIFFCHHSN DPIFFCHHSN DPIFYCHHSN DPIFYCHHSN DPIFYCHHSN DPIFYCHHSN DPIFYCHHSN DPIFFAHHSN DPIFFAHHSN DPIFFAHHSN DPIFYSHHAN DPAFYSHHAN DPAFYSHHAN DPIFFSHHAN DPIFYSHHSN DPIFFSHHSN DPIFYSHHSN DPIFYAHHAN DPLFYCHHGN DPLFYCHHGN DPLFYCHHGN DPLFYSHHAN DPLFYSHHGN DPLFYCHHGN DPLFYCHHGN DPLFYCHHGN DPLFYSHHTN ESLFYSHHAN DVLFYCHHAN DSLFYSHHCN DPLFYCHHAN DPLFYCHHAN DPLFYSHHAN DPLFYSHHSN DPIFYAHHPN DPIFYPHHAN DPIFYPHHAN DPIFFAHHGN DPIFYPHHAN DPIFYGHHGN DPIFYAHHSN DPIFFAHHAN DPIFYAHHSN DPIFYAHHSN DPLFYAHHAN DPLFYAHHAN DPLFYAHHTN DPLFYSHHAN DPIFFSHHAN DPIFFAHHAN DPIFFSHHAN DPVFYAHHAN DPVFYAHHTN DPIFYAHHSN DPIFYPHHAN DPVFYTHHSN DPVFYSNHSN DPVFYSHHSN DPVFYSHHAN DPLFYSHHAN DPLFYSHHAN DPVFYSHHAN DPLFYSHHSN DPLFYSHHAN DPIFWMHHCN

670 ....|....| IDRLWQAWRD IDRLWEVWRD IDRLWECWRR IDRLWDVWRS SDRLWEVWRG SDRLWEVWRR SDRLWEVWRG IDRLWHVWRG VDRMWHIRRG IDRLWHVWRS IDRLWSVWNG IDRMWSVWNG IDRLWSVWNG IDRLWSLWKG IDRMWSVWKG IDRMWTVWKG IDRMWSVWKG IDRMWSVWKG VDRLWDIYSD VDRLWDIYSD IDRLWTIYKE VDRMWNIWKT VDRMWNIWKT IDRMWTIWKG VDRMWTVWKG VDRMWSVWKT VDRMWTIWKT VDRMWTIWKT IDRLWEVWKK VDRMWTIWKT VDRMWDLWKK VDRMWDLWKK VDRMWDLWKK VDRMWDLWKK VDRMWDLWKK VDRMWDLWKK VDRMWNIWKT VDRMWNIWKT VDRIWNIWKT VDRMWNIWKT VDRMWNIWKT VDRMWNIWKT VDRMWSIWKT VDRMWSIWKT IDRMWSIWKT IDRMWSIWKT CDRMWCDWKN VDRMWDVWRS VDRMWDVWRS VDRMWDVWRS VDRMWDVWRS VDRMWDVWRS VDRMWDVWRS VDRMWDVWRS VDRMWDVWRS VDRLWTIWRN IDRLWSTWQG VDRMWSVWRT VDRMWTLWQY VDRMWTLWQY VDRMWYLWQR VDRMWTLWQY VDRMWTLWQF SDRLWGLWKT LDRLWTVWKT LDRLWTVWKT IDRLWVVWKT IDRLWDVWRT VDRLWEVWRR IDRLWNVWTD LDRIWNVWEE IDRLWGVWKE IDRLWGVWKE IDRLWEVWKG IDRLWEVWKG LDRLWDFWIK LDRLWAFWIA IDRLWEAWKT MDRLWEIWKT VDRLWEMWKT VDRLWCLWTH TDRLWELWLT VDRIWTVWNT IDRIWTIWKT IDRIWTIWKT VDRMWHLWST VDRLWHLWRS VDRMWHLWST VDRMWHLWST VDRMWHIWST VDRMWHLWST VDRMWHIWST VDRMWHLWST IDRLYSDWLS

680 ....|....| ---AGVARGY ---VGAARGY IA-TGNRT----NGKGE----GPARHADD-AGAGGDR -V-GGGHA-LS-PRNT--LLFPGDT--QIHNNNNGGF LR-AGNT--LR-PGNS--LR-AGNT---L-GGRRQ-LD-PRRHR--L-DDVRRRR -L-DARRHTLD-VRRHT-LR-GNKV--LR-GNKV---R-RAITTP-I-GGKNRK-I-GGKNRK-L-GGKRK--L-GGKRK--L-GGRRT--L-GGKKRT-L-GGNKRTLP-GGKRE-IP-GGTRR-IP-GGKRK-IP-GGKRK-IP-GGKRE-IP-GGKRK-IP-GGKRK-IP-GGKRK-ELLDGRRF-ELLDGRRF-IP-GGFRR-IP-TGKRR-IP-SGKRR-IP-SGKRR--I-P------L-GGKRR--L-GGKRK--L-GGKRR-LP-GGKRT--L-GNQ----L-GNQ----L-GNQ----L-GNH----L-GNK----L-GNM----L-GNK----L-GNK---QR-SGPKQPK -L-RGKKPKLK-TDVPK-FL-PSNKVPD FL-PNNKLID -L-PNNKLPD FL-PSNKVPD FL-PSNKIPD LE-GGRK--LP-RNRKGPF LP-RNRKGPF LP-GGRRR-LH-GNK---LQ-WEYYNS-L-RGNNKPLR-NNEP--LR-NNEP--LR-NNVP---M-GGRHK--M-GGRRR--Q-GGAHT--Q-GGMHS--L-PGKYRK-F-PGKYRK-L-PGKYRKLR-GGKR--KI-PGGQRT-L-PGEQRK-M-PGKQRM-L-PGKQRTKL-GNHE--TD-PGHA--KL-GRR---KL-GGK---RL-GGK---RL-GGGQ--RL-GGGQ--RL-GGGQ---R-PGHL---

690 ....|....| RGHVDFT-DP RGHVDFT-DP --HEDFT-DP ----DFT-DP ----DFT-DP PRHADFT-EP ----DFT-DP ----DFA-DA ----DFT-DP ----DFA-DP ----NFT-DP ----DFT-DP ----NFT-DP ----DIT-DP ----DLT-DP T---DLA-DP ----DLT-DP ----DLT-DP ----EFD-NP ----EFD-NP ----EFP-TD ----DFT-DT ----DFT-DT ----DFT-DP ----DFT-DP ----DLT-DP ----EFT-DP ----EFT-DP ----NFT-DP ----DIS-DP ----DFK-DP ----DIE-DP ----DIE-DS ----DIE-DP ----DIE-DP ----DIE-DP ----DHK-SD ----DHK-SD ----DFN-DD ----DFK-NR ----DFK-NR ----DFK-NR -------------DFT-DS ----DFT-DS ----DFT-DS ----GFEDDP ----DFT-DA ----DFT-DA ----DFT-DA ----DFR-DA ----DFT-DS ----DFT-DP ----DFT-DP ----DFT-DP ----DFP-DS ----GFK-DK ----DIK-DP K---KIT-DP K---KIT-DP K---RIT-DP K---RIT-DT K---KIT-DP ----DYSDDP RPRRDYK-DP RPRRDYK-DL ----DPT-DT ----VIT-DP ----EIT-DT ----AIE-DP ----EIV-DP ----EIV-DP ----EII-DP ----DIS-DP ----DLT-DP ----DFS-DP ----DYN-DP ----DVT-DP ----DVT-DP ----DIS-DP ----TYPMDS ----HPT-DP ----APV-DP ----EPN-HT ----EPT-HA ----DLT-ND ----DFVGDE ----NFD-DP ----GFD-DA ----GFD-DP ----GIT-DT ----GIT-EA ----GFT-DT ----PPS-ED

700 ....|....| DWLDSSFL-F DWLDSSFL-F DWLDSSFL-L DWLDSSFL-F DWLDSSFL-F DWLDSSFL-F DWLDSSFL-F DWLDASFH-F DWLDASFF-F EWLDAAFL-F DWLNASFL-F SWLDASFL-F DWLNASFL-F DFLDASFL-F DWLDSSFL-F DWLDASFL-F DWLNASFL-L DWLDASFL-L DWLDASFI-F DWLDASFI-F EWLEASFI-F DWLDATFV-F DWLDATFV-F DWLNAGFL-F DWLDAGFV-F DWLNASFF-F DWLDASFL-F DWLDAEFI-F DWLDAAFL-F DWLNSEFL-F DWLNSEFL-F DWLNSEFL-F DWLNSEFL-F DWLNSEFL-F DWLNSEFL-F DWLNSEFL-F DWLESSFF-F EWLESSFF-F DWLESSFL-F DWLETTFF-F DWLETSFF-F DWLETSFF-F ---ESAFF-F DWLESGLL-F DWLESGFL-F DWLESAFL-F DWMESQLL-F DYLNTEFL-F DYLNTEFL-F DYLNTEFL-F DYLNTEFL-F DYLNTEFL-F DYLNTEFL-F DYLNTEFL-F DYLNTKFL-F DWLNADYL-F DWLDATYL-F DYLNAAFL-F DFLNASFL-F DYLNASFL-F DYLNASFL-F DFLNTAFL-F DFLNTAFL-F DWLDSEFY-F DWLNATFL-F DWLNATFL-F DWLDAKFL-F DWLDSSFF-F EWLDSYFF-F EWLDSTFY-F DWLDSYFF-F DWLESYFY-F DWLDSYFY-F DYLKSQFV-F DYLRSQFI-F DYLNSKFI-F DYLNSKFI-F DYLNTAFT-F DYLNTALT-F DYLNTEFT-F DFVTSQFS-F DFLNSEFT-F DFLDARFT-F DFLDASFT-Y DFLDSRFT-Y QWLNTNFV-F DWLQTSFV-F EWLDTSFV-F EWLDTSFV-F EWLDTSFV-F DWLDATFV-F DWLDTSFV-F DWLDASFV-F EWQNQSFNEF


710 ....|....| YNE--DARLV YDE--EARLV YDE--EARLV YDE--EARLV YDE--DARLV YDE--EARLV YDE--DARLV YDE--EARLV YDE--EARLV YDE--EARLV YDE--EARLV YDE--EARLV YDE--EARLV YDE--NGQMV YDE--TPKLV YDE--TPKLV YDE--TSKLV YDE--TPKLV YDE--NRQVV YDE--NRQMV YDE--NRNVV YDE--NKQLV YDE--NKQLV YDE--NKQLV YDE--NAQLV YDE--NANPV YDE--NANLV YDE--NANPV YDE--NANLV YNE--NAELV WNE--NKELV WDE--NKELV WDE--NKELV WDE--NKELV WDE--NKELV WDE--NKELV YDE--NKNYV YDE--NSNYV YDE--NKNLV YDE--NKNLV YDE--NKTLV YDE--NKTLV YDE--NKNLV YDE--NKNLV YDE--NKNLV YDE--NKNLV YDE--NADLI FDE--NQDLV FDE--NQDLV FDE--NQDLV FDE--NQDLV FDE--NQDLV FDE--KQDLV FDE--NQDLV FDE--NQDLV YDE--NARLV YDE--NKNLV YDE--NKQLV YDE--NKQLV YDE--NAQLV YDE--NAQLV YDE--NAQLV YDE--NAQLV YDE--NANFV YDE--KRRLV YDE--KRRLV YDE--NSRLV YDE--KLQLN HDE--KRQLV HNE--KLELV HNE--KSQLV HNE--KSQLV HNE--KSQLV YDE--NKRLV YDE--NKRLV YDE--KQNLV YDE--NKTLI YDE--DGDQV FDE--DGDQV YDE--DGEQV YDH--KGNLV YDE--DANLV FDE--NGDLI YDE--NADRV YDE--NADQV YDE--TKRPV YDE--KRRPV YDE--RPRPV YDDVKSPRLV YDDYRSPRLV YDDVKSPRKV YDDVKSPRKV YDDVESPRKV YDV--DKNQV

720 ....|....| --RITVRDVL --RITVRDVL --RITVRDVL --RITVRDVL --RVTVRDML --RVTVRDML --RVTVRDML --RARVRDCL --RVRVRDTL --RVRVRDCL --RVRVRDCL --RVRVRDCL --RVRVRDCL --RVKTRDCL --RIRVRDVL --RIRVRDVL --RIRVRDVL --RIRVRDVL --NCKVRDCL --NCKVRDCL --KCKVRDCL --KVKVSDCV --EVKVSDCV --RVKVRDCL --RVKVRDCL --RVKVRDCL --RVKIRDCM --RVKVRDCI --RVKIRDCL --RCKVSDCL --RVKVKDTL --RVKVKDTL --RVKVKDTL --RVKVKDTL --RVKVKDTL --RVKVKDTL --RVKVKDCL --RVKVKDCL --RVKIKDCL --SVKVKDSL --RVKVKDSL --RVKVKDSL --RVKVKDSL --RVKVKDCL --RVKVKDCL --RVKVKDSL --RVKIKDSL --RVKVKDSI --RVKVKDSI --RVKVKDSI --RVKVKDAI --RVKVKDSL --RVKVKDSL --RVKVKDSL --RVKVKDSL --RVKNSDTL --QVNVKDAL --RVKVGDCL --RVSVKDSL --RVTVKDCL --KVYVRDTF --RVTVKDCL --RVTVKDCL --RVKVRDCL --RVRVRDAL --RVRVRDAL --RVRVRDAL --RIKIRDVL --RIKFQDVV --RIRIRDVL --RIKVRDVL --RIKIRDVL --RIKIRDVL --SVSVGQVL --SVSVRQVL --SIQVSQVL --SISVSQVL --SVTVAQAL --SVTVAQAL --SVCVKQAL --KMNVSQTL --KMKVSQVL --IVNVSQTL --TVKVSQII --IVNLSQII --RIAVRDVL --RIRVRDVL --RIRVRDVL --RMKFRDVL --RMKFRDVL --RIKFRDVL --RIRFRDVL --RVKFRDVL GSEFTCGQTV

730 ....|....| DTEK-LRYTH DIDK-LRYAY RTEK-LRYTY DMDK-LRYTY DIGR-LRYAY DIGK-LRYTY DVGR-LRYAY DPAA-LRYAY DPSA-LRFTY DMAS-LGYAY DTAA-LGYSY DTAA-LGYAY DTAA-LGYTY DNTK-LGYTY DTDR-LRYRF DTGA-LGYQY DTDR-LRYRY DTDR-LRYRY ITEN-LGYTY ITEN-LGYTY DPTQ-LRYMY DTSK-LRYQY DTSK-LRYQY DQKN-LRYTY DPTK-LRYAY DSRN-LGYVY DNKK-LGYVY DTKK-LGYIY DTTK-LRYGF DNTG-LRYTY DTKK-LRYGF DTKK-LGYGF DTKK-LGYGF DTKK-LRYGF DTKK-LRYGF DTKK-LRYGF DSKK-MGYDY DSKK-MGRRDSRK-LGYDY DSKK-MGYVY DTNK-MGYVY DTNK-MGYVY DTRK-LGYVY DTRK-LGYVY DERK-LGYVY DTRK-LGYVY DIVK-LRYTY DNQTKLKYKY DNQTKLKYKY DNQTKLKYKY DNKTKLKYEY NSEKMLKYKY NNEKMLKYKY NNEKMLKYKY NNEKMLKYKY ENEK-MGYVY DNEK-MGYTY DHKK-MGYEF DNLK-MGYEY DNTK-LGYDF DNRR-MGFDY DNLR-MGYDF DNLK-MGFEY DTKK-LGYVY KTEQ-LGYRY KTEQ-LGYRY TTEQ-LGYSY SITK-LQYAY NITR-LRYAY DMSK-LRYTY NMTK-LRYGY NITK-LGYDY NTTK-LGYEY NAGN-LRYGY SLRN-LRYGY DLDK-LRYKY NLAN-LRYDY DLDL-LRVKY NLDL-LRVKY DLDL-LRYKY DTDL-LRYKF DSRK-LRYKY DNEL-LRFRY NTTL-LRYEY NTPL-LRYEY DAEKQLGYTY EPGN-LGYAY DAAA-LGYSY DVTN-LGYTY DATR-LGYTY DTRD-LGYTY DTRD-LGYTY DTRD-LGYTY DSRV-MGYVY

740 ....|....| AGV---GMPW DGV---GTPW GGV---GLPW RGV---GLPW AEV---GLPW AEV---GTPW AEV---GLPW QDV---GLPW QDV---GLPW QEV---PLPW QDV---ALPW QDV---ALPW QDV---ALPW QDV---EIPW QDV---PMPW QDV---PMPW QDV---PLPW QDV---PLHW TTE---RHAW TTE---QHAW QTD---EKAW QDI---PIPW QDI---PLPW QEV---DIPW QEV---DIPW QDV---EIPW QEV---DIPW QDV---DIPW QDV---ASPW QNV---EIPW QDV---PIPW QDV---PIPW QDV---PIPW QDV---PIPW QDV---PIPW QDV---PIPW QRV---DLPW ------LFPF EYV--DDTPW QDV---DIPW QDV---AIPW QDV---AIPW QDV---DIPW QDV---EIPW QDV---DIPW QDV---DIPW EEV---DNPW ASMP-QDKVW ASMP-QDKVW ASMP-QDKVW ASMP-QDKVW QAMP-DDKSW QAMP-DDETW QAMP-DDKSW QAMP-DDKSW QEV---DLPW QKV---DNPW EKV---DTPW ERV---DLPW ERV---DLPW ERI---DLPW ERI---DLPW ERV---DLPW EDV---DLPW QDI---HNAW QDI---HNAW QDT---GNAW EKV---DFTW EEV---ELPW EKV---DNVW EKV---DNLW EKI---DHPW EQI---DNPW QKV---PNPW QRV---ANPW DDM---INPW DQG---DNLW QEL---PMAW QEV---PVAW TNS---SADW EDS---PTPW AEM---PTPW EQM---PTGW EES---PTAW EES---PTAW EEK--KSLEW EAR--ERLEW DER--EPLRW DKESEAALPW DKESEAALPW DAEYDRDLPW DAESDKDLPW DAEADKDLPW STD---QITN

750 ....|....| LDAKPPTTPN LDAKPPATPN LHARPPTTAG LDARPPTTPN LSARPPINPG LGARPPVNPD LSARPPVVAD LDARPARTAG LNAKPSTGAA LDARPTKPAS LNARPTTETG LNAKPAKEAG LNAKPTTETG LKSRPTPKVS TTARPTVTPR RAARPTVTAA TAARPTVTAA TAARPTVTAG KDIKRTYKKL KDIKRTYKKL LNIRRSYYTK LPKMTKAKAK LPKNTKAKAK LKTRPTAGKA LKSRPKPPNA LQSRPTPRRS LKSKPTTRRS LKSRPKSRRL INARPKRKPN LESKPIPRRL LKTRPTPKLT LTTRATPKLT LTTRATPKLT LKARATPKFT LKTRATPKLT LKTRATPKLT LLAGELIKPK V-----QNQK LNVRPRPKYA LQKRTKPKRT LEKKPKPKRT LEKKPKPKRT LKNKPKPKRS LKSKPSPRRS LNSRPTPRRS LNSKPTPRRS AHHDSLRFKK INYKPLPLAK INYKPLPLAK INYKPLPLAK IDYRPLPLAK TAYEPKPLKQ TAYEPKPLKE IAYEPKPLKQ TAYEPKPLKQ LKNRPAARVT VNYRPKPKVK LNYKPTKKAA LDYRPPPQAA LDYRPPPQTA MDYRPPLQAA LDYRPPRQSA LDYRPPAQAA LRTPPTSPKS VTARPSTAVS VTARPSTVAG ASARPTIVAG LNNRPKPSVP LNARPRPSVP LNAKPKPSVP LNARPKPSMD LNARPKPSMD LNARPKPSMD MNPKAGGMST MNPRAFGMGV LMEPPLDPPD TIEPPLDPPL TDKGTVTEGS ANKGAVQEGA VENGAVSKAA ETNGVAAGNE ITNGLEAGKE VTNGQLPGEE ITNGQKAGYE VSRGQKPGHE MERRIKPAAI LDKRPKPATG MGARPAPLLA LKXQAHPVLV LNSKPTRFSG LRPKITKLVP LRCKISSLVP LRPKITSLVP LTQTLAARSS

760 ....|....| V--------V--------V--------V--------D--------L--------V--------A--------S-----------------S--------S--------S--------S--------A--------A--------A--------T--------Q--------Q--------K--------T--------T--------K-----------------A--------M--------IKKVAN---K--------G--------R--------R--------R--------R--------R--------R--------K--------L--------V--------R--------R--------R--------K--------R--------R--------R--------H--------T--------T--------T--------T--------T--------T--------T--------T--------K--------K--------K--------A--------Q--------R--------R--------S--------K--------G--------A--------A--------L--------P--------P--------P--------P--------PAIARHALNT A--------M--------EIAPSPSITI APAAAPVTIA K--------D--------G--------F--------H--------N--------N--------K--------K--------I--------N--------R--------G--------H--------H--------H--------I---------

770 ....|....| ------------------------------------------------------------------------------------------------------------------------------V -----------------AT -------RRA ---------R ------------------------------------T ---------T --------------------------KK -----EKVAT ---------K ------------------------------------------------------------------------------------------------------------------------------------AKKL -------VQK -------VQK -------VQK ---------G ------------------------------------A ------------------------------------------------------------------------------------------------------------------------------K ---------------------------E -------KIA ---------K ------------------R--------H ---SVDGMDM ---SSDDMDM AEAFA--TEP SIMSF----E --------PT --------PS --------PQ ---------N ---------T ---------S ---------S ---------N ------------------------------------Q ----------------------------------------------

780 ....|....| ------------------N -------NPK ---------K --------VN -----------------NR -----GAPAP ---------------------------------------------LKKLKKLGKA ----RSFGTP RRADSLLTPA DSLLAPAAQA RADSFLAPAA ---RGKKRSA ---RGKKRSA ---KAAPRSA TKSSKSGVAK TKSSKSGVAK APVAPKKASP ---------VASNIFGHEK VSHHHGQVAQ VFHHDGQAAH ---------P -------KKA ---QEKSRRS ---QEKSSRA ---QEKSRRA ---QEKSRRS ---QEKSRRA ---QEKSRRA ----EIILLR ------------------KAKQVAFTQQ KAKKVAFAQQ KAKKVAFAQQ ALAQDFIVGA VALGPHFNTG VALAQNFGVG VALAQNFGVG KSLSSSVAAT ---------------------------FAQPVASLVP -----PWSGS -----PWSGS -----PWSGS -----PWSGS -------SKV ------SKAA ------AKIL -----ARITR ------AKVM --------TK -----AKINR -----AKVTR -----LLREA IQKLESVFST ------------------VARNILRMRQ RDILKMRDLD IARQILKMRE TMARHALNTK TIARHALNMR NAHQHMNSEL SGQSVEATQC SGASMEAAKC SPGPTADPTT SRDESPPPPP WSFCNPKSSE WRFCNPHSSD WKHCNPNATA IPRCNPASKS VPHCNPLTKS VPLCYRGNPT IPVCNPMNPS VTACNPLSPS ---------I ---------------KGAA DAVVVGAGGG --------GK ------GKES -----GKDSP -------GTD ------IRQQ

790 ....|....| -N-----TKK TK-----KGAK-----GGG YR-----VKN RG-----RDP SR-----RSR GR-----GGP AT-----D----------T -------PGT ----------------PAP -------PAP KA-----AAA TA-----VAA AQ-----AAS AT-----AAA QA-----APA GE-----GLS GE-----GLS GA-----D-E AA-----ELP AA-----ELP RS-----LNS -------AEI EAIAAEKKKN AA-----ETK AA-----ETL KP-----TVP AE-----TKT AK-----KSV AE-----KSV AE-----KSV AK-----KSV AK-----KSV AK-----KSV SK-----PEA ----------------PLP FGGIGAAIAA FGGIGAAMAA FGGIGAAMAA AQ-----AVE VA-----RAA AA-----RAA AA-----HAA GL-----SSI -------AFA -------AFA -------AFA GATAMAAEYP SY-----EYR SY-----EYR SY-----EYR SY-----EYR AA-----TTA KN-----SKA KI-----AAG TS-----ASA RT-----VST IN-----KVD AS-----STA AG-----KTT NK-----SPL KV-----KRP ------KSKP -------RNL NAKQQQLQRN HENNQELPSS NENPFLDSSN HN-----GYL HN-----GYL TSNGFVSGYL SALANSDVPA SSLQYSDVSA CS-----PTF SGPRICSPPN SD-----IAE AD-----IAA AD-----DDA AV-----NRL QV-----KSL KT-----RKL QT-----NAM QT-----NAM DD-----RTR DR-----PTV AA-----RST AQ-----GGV AK-----AKA GA-----AAR PR-----SSS DS-----GAA VV-----ESV

800 ....|....| GSLKSVRFP-LLKSVRFPV RLEESVRFPRVEKPVMFPPHLESVRFPQHLKPVRFPTHLKSVRFPV ----GVVFPA PAPAAGAFPPARALDALPPVPAAGALPTAGALP---AAGALP---ETHRPPKEVL SAKKATKFPAAKKARKFPAAKKAGEFPAARKAGEFPLIPVSEFGSA LIPVSEFGST LVAISEFGSE KTTISSIGDF KTTISSIGDF REESSNIFPPSSSSIVFPALTPITAFPNLSPISSFPNLPPITAFPVDTADPTKPI ALTPITAFPVLTPISAFPVLTPISAFPVLTPISAFPVLTPISAFPVLTPISAFPVLTPISAFPSTFKTLQLP---------LPFPLPQ-PL ETGPSSKFPL ETGPSSKFPL ETGPSSKFPL TTPKSVKFPETSRNVQFPETSRNVKFPETSRNVKFPILKQNVDKPV QPKSSIVASL QPKSSIVASL QPKSSIVASL LVRSSSQNAE LVKASAENPK LVKASAENPE LVKASAENPE LVKASAENPE APPPETVFPPTATDTIFPAETVEALFPAPKAETLFPTRKADAVFPAPNAKTLFPAPKAAALFPVKVEDTVFPI LSSKPSKFPLKNKLTRLNK LVSASPDSPVSNAA----DILSSNFSPH PFLSADFGPH QAIVLPELGL TAQSNDFRPN TTQSSDFTPK TAQSRDFRPK LIKSSPLLKK LVKASPLLEN GPDVSRIIRY SPRLGRMIKN MVKNTPRFKE MINRTRRFKG LIAATPAFNG IAATPKHSSK IEDTRVSKGN IADTPYFKPS IIATPELTIQ IYTTPELAAA DAKDNSSLPL KPSDVVSFPL MRRAVPAFPL GVPADADEGG APKVASEFPL SSAAAPVFPL ARKAAPVFPL KAAAAPVFPL IESKSILVEN


810 ....|....| ---VSLDAAV ---SLDDVAV ---VALDAAV ---VSLGNVV ---VSLDAPV ---VSLDAAV SLDAAVTAAV ---RL-DRTV ---ATLDKTV ---ATLDKTV ---ATLNQTV ---ATLNQTV ---ATLNRTV P--AKLDKVL ---IMLDSAT ---VTLDEAM ---ITLDEAT ---ITLDEAT P--RALNSTI P--RALNSTI P--RLLDTTI P--KALNSVI P--KALNSVI ---RALDSVV ---IKLDSTL ---LVLNKVI ---LILDKVI ---LVLDKVI G--LL-NKTV ---LVLDKTI ---VVLDKVI ---VVLDKVI ---VVLDKVI ---VVLDKVI ---VVLDKVI ---VVLDKVI ---LPLESIE ---------PFPLTLNSIQ ---TLLDSKV ---TLLDSKV ---TLLDSKV ---LTLDSKV ---LVLDSVV ---LVLDSVV ---LVLDSVV T--KCGERTR PV-KVGAGPL PV-KVGAGPL PV-KVGAGPL PV-KVGAGPL AL-EVGVEPV AL-EVVAEPV AL-EVRTEPV AL-KVEAEPV ---VKLDKVV ---VKLDKVV ---LNLKKIT ---LKLDRVV ---LKLDGIA ---LKLDRVV ---LTLDGVV ---VL-DKIV ---LVLDSIT ALGPLFRMFS ------------------G--RFLDATL G--RTLDTTI NG-KRLDTTI G--RTLDSTI G--RTLDSTI G--RTLDSTI SGNILFTTPL SGNVLSIEPL A--PPLRKNG A--KLLKKGW PV-WLKEGPV PV-WVQQDGV FL-FVKSAPT D--ILDITPL E--TLFVTPI M--VLHTVPL D--KLGAEPL G--TLDAKPL ---VLKKGRM ---ALKNGRK A--LTEGQVV GGRAVGGDPG ---TLTDEAV A--LTKGQVV ---------A--LTKGQVV V--LSFEANV

820 ....|....| SAE-VRR--P TAE-VRR--P TAE-VRR--R TAE-VRR--P TAEVSRR--P SAA-VTRTRP SRRRQGK--P RVA-VAR--P RVA-VTR--P RVA-VAR--P RVA-VTR--P RVA-VTR--P RVA-VTR--P KIM-VKR--P SVT-VRR--P SVT-VKR--P SVT-VKR--P IVT-VKR--P RVL-VPR--P RVL-VPR--P RVL-VTR--P RVE-VPR--P RVE-VPR--P KVK-VAR--P RVD-VPR--P SVK-VAR--P STV-VKR--P STV-AKR--P SVV-VQR--P VTV-VSR--P SVE-VSR--P SVE-VSR--P SVE-VSR--P SVE-VSR--P SVE-VSR--P SVE-VSR--P RTN-VKR--P ---------RTT-VKR--P TLL-VKR--P TLL-VKR--P TLL-VKR--P STL-VKR--P SIV-VKR--P STM-VKR--P STM-VKR--P DISFTNN--A TIT-VAQ--P TIT-VAQ--P TIT-VAQ--P TVT-VAQ--P TIT-VDQ--P TIT-VDQ--P TIT-VDQ--P TIT-VDQ--P KVL-VSR--P KVL-VDR--P RVL-VNK--S RFE-VQK--S RVL-IQK--T RFQ-VDK--T RFQ-VDK--T RVL-LPK--T STV-VKR--P YVPLNNL--P ---------P ----VDS--P RTR-VNR--P RVK-VHR--P RVK-VHR--P TAK-VQR--P TVK-VHR--P TVK-VHR--P TFR-VRRLAP TFR-VRRLDP TQF-STT--P TVF-SGE--P TFKLKRR--P TFKLRRQ--P TFKLKRE--P TFK-VRR--P TFR-LKR--P TFK-VQR--P TFR-VPR--P TFR-VTR--P EYLPVER--P EYLTVKR--P EVPSVAK--P EAA-REG--P DVPAVAV--P EVPAVAV--P ---------EVPAVAV--P DLS-LRT--R

830 ....|....| ---------------------------L-----------------GN-------------------------------------------------------------------------------------------------V--------V--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FHVYIPLGSV ---------------------------------------------------------------------------------------------------------------------------------------------------------TLFSG-------------A--------------------------------------------------------------------------------L--------L--------------------------------------------------------------------------------------------------R--------G--------A---------------------------------------------

840 ....|....| -----RVLRS -----RVLRS -----RRPRA -----MLWRQ -----GKPRS -----TRSRR -----RGQRE -----RVSRS -----RASRS -----RASRS -----RTSRT -----KTSRT -----RTSRT -----KKKRS -----VSSKR -----VAARR -----AVQRS -----AGKRS -----KVSRS -----KVSRS -----KASRT -----KKSRS -----KKSRS -----KKSRS -----RKSRS -----KKSRS -----KKSRS -----KKSRS -----NKKRS -----KKSRS -----KKSRS -----KKSRS -----KKSRS -----KKSRS -----KKSRS -----KKSRS -----KPRSR --------------KKEES -----KQLRS -----KQLRS -----KQLRS -----KLLRS -----KKSRS -----NKSRS -----NKSRS NAATKRRGLF -----KGSAS -----KGSAS -----KGSAS -----KGSAS -----KGSAC -----KGSGS -----KGSAC -----KGSAC -----KKSRS -----RKSRS -----AKGKA -----KKGKA -----KKGKA -----KKGKA -----KKGKA -----KKGKA -----KKLRS -----GGGDK -----TAAAD -----KLRIG -----KVRRT -----KKHRS -----KTHRS -----KNQRK -----KNQRK -----KRQRK -----TGNRQ -----TGSWQ -----TFRVR -----TFRAR -----WLSDR -----WMSEH -----YRSEL -----ARSSV ------KRRS -----RRRPE -----ERSDV -----ERSDV -----KKDGT -----EKNGG -----RAQKA -----AAHRG -----RQAGK -----AREAG -----ALTKG -----AREAG -----RLIST

850 ....|....| ---RHEKMAQ --RREKE-VQ ---QEKQAAA ----PKGATQ --------HW --------HE -----------QEEKD-EE ---REEKEEE --AKEKE-EQ ---RQEKDAE --RKEKD-AK --RQEKD-AE --KKEKD-EL --SKLEKSAK --SEAEKASE --KAEKA-SK --KAEKD-SK --TDEKE-EF --TDEKE-EF --QEEKD-EA --KKEKE-DE --KKEKE-NE --KKEKE-DE --KKEKE-DE --KKEKE-DE --KEDKE-EE --KKEKE-EE --KKDKD-EA --RKEKE-EE --ATEKE-DE --ATEKE-DE --ATEKE-DE --ATEKE-DE --ATEKE-DE --ATEKE-DE NENEEEEEGV ---------WSEVEKA----KKDKE-ED --KRDKE-EE --KRDKE-EE ---KEEKEEE --KKEKE-EE --RKEKE-EE --KKEKE-EE GLFQSSSVVV --------------------------------------------------------------------------KKEKE-SE --KKDKE-DE ---------------------------------------------------------KEEKEQE SDDDDDDDEV ---VIEEFGE KKEEEEDDEE --KKEKE-EE --KKQKDFKE --KIEKE-EE ------AENE ------TENE --TE----DE --------------------RLDTTGKG --RIDPSGNS --------HG --------LG --------HG ---------G --------EG --------VG ---------G ---------G --------KT --SKKAP--AAGGGGKQPA --HRVRPADQ ------------------K ------------------K --AAVGVPNY

860 ....|....| EEVLV----EEVLV----EEVLV----EEVLV----EEVLV----VEVLV----EEVLV----EEVLV----EEVEI----EEVVV----EEVLV----EEVLV----EEVLV----EEILI----EEVLV----EEVLV----VEVLV----EEVLV----SEVVV----SEVVV----AENIF----EEVLL----EEVLL----EEILV----EEVLV----EELLV----EEILV----EEVLL----EEVLV----DEVLV----DEVLV----DEVLV----DEVLV----DEVLV----DEVLV----DEVLV----EEVLV--------------EVLV----EEVLV----EEVLV----EEVLV----EEVLV----EEVLV----EEVLV----EEVLV----EEILI----DELLV----DELLV----DELLV----DELLV----DEILV----DETLV----DEILV----DEILV----EELLV----EELLV----DEVLV----DELLV----DELLV----DEILV----DESLV----DELLV----EEVLV----EEILV----AEILV----EEVLV----EEILV----EEVMV----EEVLV----EEILV----EEILV----EEVLV-----EILE-----EILV----FEVLT----FEYLT----EELLQ----EEMLE----EELLE----TEVLE----TEVLE----VEVLE----VEVLE----VEVLE----DEVLV-----EVLV----DTILV----QQVRRDHQRA DLVLL----EQLLV-----QVVE----EQLLV----VVRLR-----

870 ....|....| --------VE --------ID --------VE --------VE --------VE --------VE --------VD --------VD -----------------VE --------VE --------VQ --------VE --------IQ --------IG --------VD --------ID --------ID --------VE --------VE --------ID --------IK --------IK --------IE --------IK --------IQ --------VD --------ID --------IE --------IE --------IE --------IE --------IE --------IE --------IE --------IE --------ID -----------------ME --------ID --------ID --------ID --------ID --------IE --------IE --------IE --------LE --------LE --------LE --------LE --------LE --------LE --------LE --------LE --------LE --------IE --------IE --------LE --------LE --------IE --------LE --------LE --------IE --------IE --------IQ --------IQ --------IQ --------VH --------VY --------VY --------VY --------VY --------VH --------IN --------IE --------FS --------IN --------IK --------IK --------LK --------IS --------IS --------LS --------IE --------IQ --------VD --------ID --------FD QGGRRQGGAQ --------IE --------ID --------VP --------ID --------IE

880 ....|....| GVETNG--NE GIETDG--AD GIEADA--GD HIQTDG---GIKADG--AD GIEAHG--GD GIEADG--AD GIQVADH-LR ---PDH--ST GIQVSDC-SR GIEVADHFSR GIEIADHSSR GIEVADHFSR GIELER--DV GIEVDM--DI GIEVDR--DV GIEVDR--DV GIEVDR--DV GIKFGH--GE GIKFGH--GE DFTFDH--TD GIELDR--EN GIELDR--EN GIEYDR--DS GIELER--DK GLEFDK--TK GIELER--DA AIEFER--NA GIEYRI--DL GIEYDK--GK GIEYEE--NQ GIEYEE--NQ GIEYEE--NQ GIEYEE--NQ GIEYEE--NQ GIEYEE--NQ -VEYDS--TD ----------VEYDM--TE GIEFDG--DD GIEFDG--DD GIEFDG--DD GIEFDR--NK GVEYDS--NI GIEFER--NT GIEFER--NT NIQSPT--GK EMVVGM--QN EMVVGM--QN EMVVGM--QN EMVIGM--QN GMEINM--QS GMEIDM--RS GMEIDM--QL DMEIDM--RS GIEVDT--AK GIEVDN--SK NIETDT--TK NITVDT--TK DITVDT--SK NITVDA--SK DIKVDT--TK NIVVDT--SK GIEFGS--DK GVELDY--NK GVELDY--NK GVEIDC--DR GIDIPE--ER GIEVKE--DS GIEIKK--DM GIDTKE--DV GIDIKE--DV GIDVKE--NV NIEIDW--TK NIAIDW--TQ DLVMDW--TE DLVLDW--TK A-NFPW--NS G-NFNW--SS G-KLDW--HQ GLQIPNI-TL GLFIPNI-TD GLSLIP--AL GIKVDG--RF GIKVDN--TL -VTLDP--CE -VDIDP--CE GVEFEP--GK GLRVRRQLHR GIEYDP--QI GIEFDP--QA AVPVPA---GIEFDP--QA GVKTPK--QQ

890 ....|....| LVKFDVFVNA MVKFDVYVNA FVRFDVYVNA VCKFDVFVNA FVKFDVYVNA FVRFDVYVNA FVKFDVYVNA YVKFDVFVNQ YVKFDVFVNA FVKFDVLVNV FVKFDVFVNE FVKFDVFVND FVKFDLFVNE YAKFDVYIND AAKFDVFVNA AAKFDVFVNA AAKFDVFVNT AAKFDVFVNT STKFDVYIAK STKFDVYIAK YAGFDVFVTK FVKFDVYIND FVKFDVYIND MVKIDIYIND FVKFDIFIND ALKFDVYIND AVKFDVYVND LVKFDVYVND YIKFNVLIND FVKFDVFIND LIKFDVLVND LIKFDVLVND LIKFDVLVND LIKFDVLVND LIKFDVLVND SIKFDVLVND GVRFDVFIND ---------DVKFDVFIND DVKFDVYITD DVKFDVYITD DVKFDVYITD AVKFDVFIND PVKFDVLIND PVKFDVFIND PVKFDVFIND KISFKIFMDI NTNFNVFINL NTTFNVFINL NTNFNVFINL NTNFNVFINL PISFNAFINL AISFNAFINL PMSFNAFINL AISFNAFINL FVKFDVFVND FVRFEVFIND FIKFDVFVND FLKFDVFVND FLKFDVFVND LLKFDVFVND LLKFDVFVND FLKFDVFVND YVKFDVHIDD ATKFDVYINY ATKFDVYINY ATKFDVYINL YVKFDVYVNV YVKFDVYVNA YVKFDVYVNA YIKFDVFVNA YVKFDVYVNA YVKFDVYVNA KAKINAFLFY TAKINAFLFH PAQIHAFLFL PAQIHAFLFL SHLINVFAFL NHALNAFAYY RHLQNIFVFL QAHWKAFLFF QVHVKAYVFF QAHWEAFLFL QSHWEAYLFF QSHWGAYLFF QVKFDVLVNV YAKFDVLVNV GGKFDVVINV RAELQRRRRD NNKFDVVINV NNKFDVAINL ---------NNKFDVAINV NTGVFVFLGP

900 ....|....| MEHEK--VE-VEYEK-VE-RDYHR-VP-REHKK-IEVDHEK--IMVEHEK--VS-VDHEK-VGCAGGDA-S-PESGDG-AAPDGDAE-SGCQGGGG-MG---SQSGGGM SQSGGG-MG-EDDET-STGDDHAA-VG-EDHGA-VG-EDHAA-VG-EDHGA-VG-PIEGL-VG-PIEGL-VG-ATEGL-AT-EDYSV-SR-EDYSV-SK-EDETT-TN-EDDPV-SR-EDDSL-SA-EDDSP-SG-EHDSTSAR-VPDTP-GK-DVEMP-SK-EPDSP-GG-EPDSP-GG-EPDSP-GG-EPDSP-GG-EPDSP-GG-EPDSP-GGQGDNE--IG----------QGDDE-IG-EDVEE-IG-EMSRD-IG-EDVED-IG-EDDKV-IT-EDDKQ-IQ-EDDKQ-IR-EDDKQ-IR-DADDT-TSPEANET-TTPEANET-TTPEANET-TTPEANES-TTPEANKN-TRPEANKN-TPPEANKN-TRPEANKN-TREDDEAA-DE-EDDKP-EDL -EDDGS-VE-EDDGA-TEEDDN---VGE -EDDNP-SE-EDDNP-GE-EDDNV-AE-DEDNL-SEPNANEN-TPPNANEN-TSPGADEN-TS--VNETIMNVDETLM-VG-VDETI-IGVDAIT--IGIDATT--IG-INTSI-IGPGASG--SSPSASG--SS-PNATA-AS-PSATE-YSPDANYETSSPDANYERTSPNSTYETTSPQVNFT-HGPQAVIT-DGPNGNNK-TTPSVDIN-TPPSAELN-TSPRGEEDKVGPRGQEGKVSPPEQAAGAGARGEGHALHAREDAARVGPADKALQVG-------QGPADKASQVG-DITAE-TP-


910 ....|....| AGGRELAGTF PGGREMAGSF SGGREMAGSF PCGREMVGSF PGGREMAGSF PGAREMAGSF PGGREMAGSF TAAAECAGSF TCAATCAGSV MGAAYCAGSV AAVAQCAGSV PAAAQCAGSV AAAAQFAGSV EENTEFAGSF SGGRELAGSF SGGRELAGSF SGGRELAGSF SGGRELAGSF PDLGELAGSF PDLGELAGSF ADLGEFAGSF PKNSEFAGSF PRNSEFAGSF PAQSEFAGSF PDNTEFAGSF PDKTEFAGSF PENSEFAGSF PDNSEFAGSF ADDAEFAGTF PENTEFAGSF PDKSEFAGSF PDMSEFAGSF PDNSEFAGSF PDKSEFAGSF PDKSEFAGSF PDKSEFAGSF PQDSEFAGSF ---------PEDSEFAGSF PENTEFAGSF PESTEFAGSF PESTEFAGSF PSNTEFAGSF PEDSEYAGSF PDNTEFAGSF PDNTEFAGSF TADLSFVAIY LSCAEYVGSF LSCAEYVGSF LSCAEYVGSF LSCAEYVGSF VSCAEYVGTY VSCAEYVGTY VSCAEYVGSY VSCAEYVGTY LDKAEYAGSY RDKAEFAGAY LDKAEYAGTF LDKAAYAGTY LDKAAYAGTY LDKASYLGTY LDKAAYLGTY IDKASYAGTY PDQTEFVGTF VNVVEFAGTF VNVVEFAGTF CNVAEYAGTF PRFREFAGTF PEFREFAGTF PESREFAGTF PESREFAGTY PESTEFAGTY PESTEFAGTY IDCMEFFGTF IDCMEFFSTF ISCPEFFGTF TGCHEFFGTF IGCLEYIGNL VGCFEYIGNL IGCLEFIGNM AICPEFVGTY PVCPEFLGTF VSCPEFIGTF VSCPEFFGTF VSCPEFFGTF PQNSQFAGSF PQNSEFAGSF PRHSEYAGSF RRGAGRPRAH PKDSEYAGSF PQYKEYAGSF PGEGAAAGDR PQYKEYAGSF ISAPGYVGNF

920 ....|....| VSM---KQPVCL---MHPVTL---KHPVCL---RHHVSL---KHPVSL---KQPVSL---KHPVLT---PHVI ALA---PHGALT---PHAAMT---PHLALT---PHAAMT---PHLVNV---PHKVSV---PHRH VNV---PHRVNV---PHGH VNV---PHRH VRV---THTVRV---THTVHI---PH-VNV---PHKVNV---PHKVNV---PHKVNV---PHQVNV---PHKVNV---PHAVNI---PHKVNV---PHNVNV---SHKVNV---PHKVNV---PHKVNV---PHKINV---PHKVNV---PHKVNV---PHKVTL---PHSP ------QHSMTL---AHSATL---GHSSTL---GHSSTL---GHSVSV---PHSVTV---PHSVSV---PHSVSV---PHSNNL---PLRYNI---PHFYNI---PHFYNI---PHFYNI---PHFSNV---PHFM SNV---PHFM SNV---PHFSNV---PHFSQV---PHRSQV---PHKAQV---PHKAQV---PHKAQV---PH-AQL---PHKAQV---PHKAQI---PH-VNL---FHGVNV---PNSVNV---PDSVNV---PHFVHI---DPGVNI---PIGVNM---KRGVNL---PRGVSL---PKGISL---PHGAHI---PASAHI---PEASHI---PEASHI---PQALSF---PHVLSF---PHTFSF---PHPNFI---PHVNFI---PHINYV---AHVNFV---PHVNFS---PHVSTV---PHGVNL---PHGATL---PRGQRE---RRRSAV---PSSAVV---PGSGHRVRPP--AVV---PG-TFF---EGQ-

930 ....|....| SMDHR----T SMDG-----T ---------G NTQN-----N ---------RME------A ---------QQKEE----G IHR------E EKR------K VRP------G VRP------G VRP------D ---------H RH-------D HAHGHGR--G GHRHGH---G GHGHGH---A HH-------K HH-------K ---------A ---------H ---------H H--------G ---------H ---------H ---------H ---------H ------------------------------------------------------------------------H--------V ---------H--------G HSN------M ---------HSN------M H--------V H--------K H--------K H--------M SI-------D MPG------M MPG------M MPG------M MPG------M L--------G LE-------S IL-------K MSD------I ---------------------------------------------K --------PR ---------S ---------K ------------------A ---------A GDRR-----G VTRVARES-N ---------V VRLIMNK--E VTRVLND--G ITLVLNE--G RTLLLNQ--G N--------H H--------H A--------R D--------H GQA------P G--------M G--------M ---------G ---------G ---------G ---------G ---------G GTMT-----G GGDGGM---K GS-------K ---------H ---------N ---------------------------S GGGNRKRWSH

940 ....|....| GKRKPMKTSM GKGMGIQTSM KEGTALRTRM VTRRGVQTTM -GNMVVQSSM AVGEVASTSM -GEVVVQTSM GGGSPVKTAA GQLSPRKTEA EKGAMMKTVA KGRGSVKTAA KGKGTVKTVA KRRGSVKTAA KHGKKIKTQL KKEKKIKTKL KKGGGIKTTL KKGRGIKTKL KKGRGIKTKL KDKVETTSKI KDKVETTSKI HGPSDHRNIL MKEMKTKTNL MKEMKTKTNL MKMKKLNTCL SHGKKKNTIL KHGKKMTTCF KHGKKMKTCL KHGKKMKTCL -RNKTVKTSL -HAKKSKTRL -HAKKSKTTM -HAKKSKTTM -HAKKSKTTM -HAKKSKTTM -HAKKSKTTM -HAKKSKTTM NHNNITKASF -RHYSSLSFW HQSKRTTTSL NMDKKIKTSL HSNMNMDEKI NMDKKIKTSL HKNKKIKTCF HKNKKIITCL HKNKDIITCL HKNKDIITCL EEQKQDKVTF TESSTRTTNA TESSTRTTNA TESSTRTTNA TESSTRTTNA IGEHTETVNT GKWHTETVNT SGEHTEIVNI GKGHTEIVNA -NSTTVKTRI -NSTRTKSKI TKDKKGKSTI TANKTATTSI TNEKTATTTI SGTTSNSSSI ANNNSSTSSI TKEKTATTSI -QGHNINTSF GKGHIMETEV GKGHIMETEM GPGHMRTTDL IEVFRKKTDL WPVMRRKSNL DLIVKRKTVL DVETKSKSTL EVKRKSKSTL DVKTKSKSTL KKKLGYSRSW RKKKGYTRSW TRPKDFSMTW HRPSDFSMQW AVPPVVKVYW SPGIKPVIRF SPDLQPELTF QAKYNPKRVW QALYNPGRVW QALFNRERRW QAQFNRDRVW QAQVTRDLVW SATTKPVVSC VGMGRLKLAY KPGETVVVPF RAGSSHRR-AAGGTLVGKF GGGETRIGKV ---------GGGGTRKGKV GHKKNVLLNA

950 ....|....| RVALNELLED RVALNELLED TVALNELLED RVALNDILKD RVALNELLED RVALDELLED RVALKEILED RFGITDLLDD RFGICDLLDD RFGVCDLLEN RFGICDLLDN RFGICDLLDD RFGICDLLDD RLSITDILED RLALNEQLED RLALNEQLED RLALNXAARG RLALNEQLED ELGVTNLLDD ELGVTNLLDD HLGITYLLED RFAINELLED RLAINELLED RLGIADLLEE RIGISELLED RLALTDLLED RLGITDLLED RLGLTDLLED RLGISELLED ILGITELLED VLGITGLLED VLGITGLLED VLGITGLLED VLGITGLLED VLGITGLLED VLGITGLLED KLPLTYKLKD N--------RLAITDLLKD TLGITDLLED KTSL-----TLGITDLLED RVGLTDLLED RLGLTDLLEE RLGLTDLLEE RLGLTDLLEE SIAMGMKLRS RFSIKPNVEI RFSIKPNVEI RFSIKPNVEI SFSIKPNVEI TFSIKANVEI SFSIKANVEI TFSIPDRLAS TFSIKANVEI RLGLTELLED RLGLTELLED SLRLTELYED RLKLTELYDD RLKLTELYDD RLKLTDLYDD KLKLTELYDD RLKLTDVYED KVGISKVLEC RLGISDTLEQ RLGISDTLEQ RLGISDTLDQ KLGISELLED KLGISELLQD KLGISELLED KLGISELLDD KLGISELLDG KLGISELLND RLGLTTKLAQ KLGLTEKLVQ TLGLTTRLRE TLGLTSKLQD KFALLP---RMGIQRKLEL RFGIRRKLEV RVAVGPKLKA RAAVGPKLKA RVALGPKIMA RVAVKDKLVA RVGIRQKLID RFKLQELIQD RFALRELIED VLPLDEVLAD ---------TLALDGVLAD TLCITDVLYD ---------TLCITDVLYD TEAVKRLYGD

960 ....|....| LGAD-GDESV LGAD-GDDSV LGAE-GDDSV LGAE-QDESV LGAE-GDDSV LGAD-GDDSV LGAE-GDDSV IGAD-GDVTI IGAD-GDKTI IGAD-GDEMV IGAD-GDKTI IGAD-GDKTI IGAD-GDKTI LDAE-DDEHV LDAE-GDESV LEAE-DDESV PQGRRRRERG LEAE-GDESV IEAE-ASDSL IEAE-ASDSL IADAEASEQL LGAE-DDESV LGAE-DDESV IDAE-DDDEI LEAE-DDDSV LDVE-GDDSL LGAE-DDDSV MGAE-DDDTV LEAE-DDESV LESD-GDDSI LEAE-GDDTL LEAE-GDDTL LEAE-GDDTL LEAE-GDDTL LEAE-GDDTL LEAE-GDDTL LGVTKDDDSI ---------LHAL-DDESI LDAE-NDDSI ---------L----DADNA LEAE-NDDSI LEAE-DDDSV LEAE-DDDSV LEAE-DDDSV LELR-KRTCI LGLK-DADKL LGLK-DADKL LGLK-DADKL LGLK-DADKL LGLK-SADKL LGLK-SEDKL HSRGLPFSML LGLK-SADKL LDVE-GDDKI LDVD-DDDQI VDVA-DDDTV MDVG-DDDTI MDVT-EDDTV IDIG-DDDAI MDID-DDDTI MDVT-DDDTI LEAE-EDDVV LGLE-DADYI LGLE-DADYI LGIK-DARNI LEAE-GDENI LEAD-EDESI LEAE-GGESI LQAN-EEDSI LQAN-EEESL LQAN-EEESI LGKS-GFSQV LGLS-QVSHA IGKL-HVRHV IRKP-YVSHV ---------MSRA-HLKEV MGRA-NLTEI LGLD-HVKSV LGLD-YVNHV LGKE-NYTDV LGKD-NYTDI LGKD-DYDDI LNCN-RSKML LRCG-GDATL IGVGDEDGAV -----GDQDL LGLA-GASAV LDAE-DDSSV -----GEQ-LDAE-DDSSV TRLS-ESNSL

970 ....|....| TVTLV-PRRG TVTLV-PRNG TVTLV-PVTG TVTLV-PRHG TVTLV-PVEG TVTLV-PVAG TVTLV-PVEG VVSLV-PRCA VVSIV-PRCG VVSLV-PRCG VVSLV-PRCA IVSLV-PRCA VVSLV-PRCA LVTLV-PTNA VVTLV-PRQG EVTLV-PRQG GHPRAAPRQG VVTLV-PRQG VVSLV-PQHG VVSLV-PQHG VVSIV-PRSG IVTIV-PRAG IVTIV-PRAG VVTLV-PRQG VVTLV-PRYG IVTLV-PRYG VVTLV-PKCG VVTLV-PRYG VVTLV-PVTN VVALV-PRSN VVTLV-PRTG VVTFV-PRTG VVTLV-PRSG VVTLV-PRTG VVTFV-PRSG VVTLV-PRTG SVTLA-PIYG ------P--AVTLA-PRYG LVTLV-PRSE ---------IVFCI----LVTLV-PKYG VVTLV-PRYG RVTLV-PRYG RVTLV-PRYG PISLV-PVPG VVTLV-PRGK VVTLV-PRGK VVTLV-PRGK VVTLV-PRGK VVTLV-PRGQ VVTLV-PRGD DFDFF----VVTLV-PRGD LVTLV-PKAG LVALV-PKAG VVTLI-PRSN VVTLV-PRHQ LVTLV-PRHE VVTLV-PRHQ VVTLV-PRHQ LVTLV-PRHE LVTLV-PKVG VVTLV-PRGS VVTLV-PRGS VVTLV-PRGV WVTLL-PRSE WVTLI-PRAE WVTLV-PRGG WVTLV-PRGG WVTLV-PRGG WVTLV-PRGR VVTLV-QVGS VITLV-QVGS VVTLV-QIGS VVTLV-QVES ------PRRS VITLVGEAPV VITMV---GE IVTLVQPPGP VFTIV-QTGK VITLA--QFG IVTLV--QFG VVTLV--RFG NITLV-PVEG DVTLV-PVAG NVVIV-PRTP ------PAAD DIVLV-PHTE DVVIV-PRTD ---------DVVIV-PRTD KVSIV-TRSL

980 ....|....| N--------K--------Q--------K--------R--------R--------R--------GDV------CDS--------GEL----GDM------GDM------GDM------GDS------KGK------RGK---------------KGR------D--------D--------E--------GDD------GDD------KD-------ADV------KGL------NGL------KGL------IGE------SVSDP----GDS------GDS------GDS------GDS------GDF------GDF------DKP---------------NKP------NVT-----------------IDD----KGL------KGR------KGR------KGR------TNGNAHM--DKEKV----DKEKV----DKEKV----DKEKV----GT-------GS------------------GS-----GED------GED------GDD------GPGEAASFLY VPR------GPG------GPVLP----GPG------KGD------SGP------SGP------GRLDP----GCIN-----DCMN-----TGIN-----TGVH-----TGVH-----TGVH-----NQH------DQQ------EQL------NQQ------SAG------ASTDDTGETG NAAPPFIAGE WLQD-------PQM----PNIQP----PNVQP----PSIQQ----DK-------EM-------G--------HRERM------GEI----AK----------------AK-------FGDQNAFASV

990 ....|....| --VRIGG----VSIGG----VTIGG----VRIGG----VRIGG----VRIGG----VRIGG----VTVDG----VTVAG----VTIGG----VTVGG----VTVGG----VTVGC----ITIHG----VKIGS----VKVGS-------------VKIGG----VTIGG----VTIGG----VTLTG----VTIGG----VTIGG----VTIQG----ITIGG----AKIGG----VKIGG----VKIGG----ATIGT----VVISG----VTVAN----VTVAN----VTVAN----VTVAN----VTVAN----VTVAN----VTIKD----LSVQT----VTIKG----ITIQS-------------KEIND----VTIRD----VQIGG----VKIRG----VKIRG----ISVSN----FTFKG----FTFKG----FTFKG----FTFKG----FTLKG----FTFNG----LVINK----LTFRG----ITIGG----ITIGG----VTIGG--FIFSLIG----LNLNGTVP --VTIGG----LVVSR----VTIGG----VIIGG----VTFKG----VTFKG----IKFKG----TTVDG----VTIDG----TTIDG----TSVEG----TSVDG----TRVDG----IKFGA----IKFGS----IRFQD----IKFKG----CSSSG----FNLTS--AGFNLTS----IKFTK----LSFQK----ITFER----LGIGK----LQLGG----TIVDN----VVVDG----IKIIS--P -----------KLYLP----VTINV-------------VTINA--EEIQPNM---

1000 ....|....| LRIVYMTE-LRIVYMME-LRIVYMDE-VRIEYNGM-LRIVYMAE-LRIVYMVE-LRIVYMTE-VSVTYVK--VSIGYAK--VSIGYAK--VRIEYVK--VGIEYVG--VRIEYIK--VKIELDD--VKIELID--VRIELVR-----------VKIELMH--VRIDLFASDI VRIDLFASDI VSIQLVPKEG IEIEFVSD-IEIEFVSD-IKIVVAS--IEIELAS--IKIEFDQD-IKIDFTQD-IMIDYIQD-LRIELLKD-VKIEFVKE-VKIEFVAD-VKIEFVAD-VKIEFVAD-VKIEFVAD-VKIEFVAD-VKIEFVAD-VRIKRVYPEV ---------IKIKLVPLVE IKIEFEKEE---------SRKN-----IKIELETE-IKIDLVAD-IKIKLLAD-IKIELLSD-IYIKSVIP-ASIQYA---ASIQYA---ASIEYA---ARIQYA---ASIQYA---ASIQYA------------ASIQYA---INIIYADDDIKIIYAS--IKIIASPPRS LQCYVLCLLI LKWKYVIAHI IKIIENPTKP LSRIHRNRLP IKIIENPTPA IKIEFIPK-FKIKYET--FKIKYET--FKIEYE---LRIEYIR--IRIEYIE--VRIEYMR--IRIEYMA--IRIEYMA--IQIEYIA--TKIKLEK--ARILLED--AIIEIDSS-ITMEIDRKW---------LTIIYSKE-AKIVYSKN-AKILYDTSGARIIYDLSPE AVVVFDTDGV ARIVYDASPA TQVLYDTSPT LRVELC---VRVELLK--PRIEIRER----------PTIENA---RPIIKNRN----------RPTIKNRN-VQIDVVDLNA