227 systemic markers of oxidative stress in relation to ... - CiteSeerX
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227 systemic markers of oxidative stress in relation to ... - CiteSeerX
The purpose of this study was to analyze the clinical correlates of systemic OS markers in a well characterized group of patients with MetS. Material and method.
Original Research
SYSTEMIC MARKERS OF OXIDATIVE STRESS IN RELATION TO METABOLIC SYNDROME COMPONENTS MIHAELA MOCAN1, ŞTEFAN VESA2, ŞOIMIŢA SUCIU3, SORIN NICU BLAGA1 1 Departament of Internal Medicine, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Romania 2 Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 3 Departament of Physiology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania 1 st
Abstract Introduction.The potential role of oxidative stress (OS) in metabolic syndrome (MetS) is rapidly evolving. Reported results support the concept that increased OS may play a key role in the development of atherosclerosis, hypertension and diabetes. Study aim. The purpose of this study was to analyze the clinical correlates of systemic OS markers in a well characterized group of patients with MetS. Material and method. 72 hospitalized patients with a mean age 59.19+/5.26 years were studied between October 2010 and June 2011. MetS was diagnosed based on the AHA/NHLBI/IDF 2009 definition. OS was assessed by urinary 8-isoprostaglandinF2α (8-isoPGF2α) (immunometric assays) and plasmatic uric acid (UA). Antioxidant status was evaluated by plasmatic glutathione peroxidase (GPx). These data were compared to those of 100 subjects without MetS (mean age 59.93+/4.7 years). Results. All biomarkers were significantly higher in MetS patients as compared with healthy individuals (p
