YTHDF2 (10 μg per lane): upper band was detected by anti-flag antibody; lower ...... TM9SF4. 7. 11. 21. III. TMA16. 2. III. TMBIM1. 2. III. TMBIM4. II. TMBIM6. 11.
37. Trapnell, C. et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511-515 (2010). 38. Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008). 39. Corcoran, D.L. et al. PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data. Genome Biol. 12, R79 (2011). 40. Bolte, S. & Cordelieres, F.P. A guided tour into subcellular colocalization analysis in light microscopy. J. Microsc. 224, 213-232 (2006). 41. Clement, S. L., Lykke-Andersen, J., A tethering approach to study proteins that activate mRNA turnover in human cells. Methods Mol. Biol. 419, 121-33 (2008).
Extended Data Figure Legends
Extended Data Figure 1 | YTH domain family members are m6A-specific RNA binding proteins. a, Western blot showing YTHDF1 and YTHDF3 pulled down with an m6A-containing RNA probe. *Thiol-substituted phosphodiester bonds were used to prevent enzymatic cleavage. b, LC-MS/MS showing that m6A was enriched in GST-YTHDF1- or GST-YTHDF3-bound mRNA while depleted in the flow-through portion. c-d, Gel shift assay measuring the dissociation constant (Kd, nM, indicated at the upper left corner of the gel) of GST-tagged YTH domain family proteins (c, YTHDF2; d, YTHDF1 and YTHDF3) with methylated and unmethylated RNA probes. 4 nmol RNA probe was labeled with 32P and the protein concentration ranged from 20 nM to 5 uM. Kd (nM) values were indicated at the upper left corner of the gel.
Extended Data Figure 2 | Features and comparisons of YTHDF2 PAR-CLIP data with 30
RIP and m6A-seq. a, Left: PAR_CLIP gel image showing
32
P-labeled RNA-YTHDF2
complex; Right: western blotting of HeLa cell lysate with over-expression of flag-tagged YTHDF2 (10 μg per lane): upper band was detected by anti-flag antibody; lower band was detected by anti-GAPDH antibody. b, Overlap of transcripts identified by PAR-CLIP and RIP-seq of YTHDF2. c-d, YTHDF2 binding motif identified by MEME with top 1,000 scored PAR-CLIP peaks under different motif searching parameters. c, With motif length restricted to [5-10] bp, p = 1.1 e-43, 183 sites were found under this motif. d, The motif length was restricted to [5-12] bp. The motif with lowest p-value was shown in main text as Fig. 1c, this motif showed the second lowest p-value, p = 5.1 e-14, 104 sites were found. e, With [7-12], p = 7.5 e-42, 231 sites were found under this motif. f, Distribution of PAR-CLIP peaks across the length of mRNA. Each region of 5’UTR, CDS, and 3’UTR were binned into 50 segments, and the percentage of PAR-CLIP peaks that fall within each bin was determined. g, Overlap of YTHDF2 PAR-CLIP peaks with m6A peaks in different sub-transcript regions. Over 70% PAR-CLIP peaks in 5UTR, CDS, stop codon, and 3UTR regions overlap with m6A peaks (at least 1 bp overlap). In contrast, only 20%~30% of PAR-CLIP peaks in transcription starting sites (TSS) and intergenic regions coincide with m6A peaks. h, Enrichment of YTHDF2 PAR-CLIP peaks in long exons. The length distribution of exons that contain YTHDF2 PAR-CLIP peaks (red) shifts to larger size compared with the length distribution of all exons in human genome (black).
Extended Data Figure 3 | Effects of YTHDF2 knockdown and summary of the sequencing data. a, The YTHDF2 knockdown efficiency is about 80% as detected by 31
RT-PCR (error bars, mean±s.t.d., n = 3, biological replicates) and RNA-seq. Although at current stage we could not identify a reliable antibody for YTHDF2, ribosome-profiling of YTHDF2 did indicate that the translation level of YTHDF2 decreased by 80% after siRNA knockdown. RT-PCR results were normalized to that of GAPDH as an internal control. RNA-seq and ribosome profiling results were calculated by actual RPKM. b, YTHDF2 knockdown led to decreased translation efficiency of its targets due to the accumulation of non-translating mRNA. Translation efficiency is calculated as the ratio of ribosome-protected fragments and mRNA input. P value was calculated by using Mann-Whitney U test (two-tailed, significance level = 0.05). c, Multiple pairwise comparisons (Kruskal-Wallis test) by using the Steel-Dwass-Critchlow-Fligner procedure (two-tailed, significance level = 0.05). d, The regional effect of the YTHDF2-binding site is not significant. Cumulative distribution showing mRNA lifetime log2-fold changes (Δ) between si-YTHDF2 and si-control for non-targets and CLIP-IP common targets with major CLIP peak at 5UTR, CDS, 3UTR, intron, and non-coding RNA. Except for intron, other regions show similar fold changes (also see Extended Data Fig. 3c). e, The m6A methyltransferase (MT-A70) and demethylase (FTO) remain unchanged with YTHDF2 knockdown.
Extended Data Figure 4 | Validation of representative YTHDF2 RNA targets. a-d, Examples of transcripts harboring m6A peaks and YTHDF2 PAR-CLIP peaks: SON (CDS, a), CREBBP (3’UTR, b), LDLR (3’UTR, c), PLAC2 (non-coding RNA, d). Coverage of m6A IP and input fragments are indicated in red and blue, respectively. YTHDF2 PAR-CLIP peaks are highlighted in green. Black lines signify CDS borders. e-n, relative RNA level quantified 32
by gene-specific RT-PCR, and error bars shown in these figure panels are mean ± s.t.d., n = 6 (two biological replicates × three technical replicates). e, Enrichment fold of SON, CREBBP mRNA, and PLAC2 RNA in YTHDF2-RNA co-IP versus RNA-protein input control, and in m6A in vitro IP versus mRNA input control. f, Relative changes of SON, CREBBP mRNA, and PLAC2 RNA in siYTHDF2 sample versus siControl, and over-expression of YTHDF2 versus over-expression of C-YTHDF2. g-k, Lifetimes of SON, CREBBP mRNA, and PLAC2 RNA under siYTHDF2 versus siControl. l-n, YTHDF2 knockdown altered the cytoplasmic distribution of its mRNA targets. The SON (l) and CREBBP (m) mRNA levels decreased in the non-ribosome mRNP portion but increased in the 40-80S portion under siYTHDF2 compared to siControl. However, they showed different changes in the polysome portion. RPL30 (n) is not a target of YTHDF2 and did not show an increase in the 40-80S portion.
Extended Data Figure 5 | Knockdown of METTL3 (MT-A70) led to less binding of YTHDF2 to its targets and increased stability of its target RNAs similar to that of YTHDF2 knockdown. a, Western blotting showing that the knockdown efficiency of siMETTL3 at 48 h was ~80%. b-g, relative RNA level quantified by gene-specific RT-PCR, and error bars shown in these figure panels are mean ± s.t.d., n = 6 (two biological replicates × three technical replicates). b, Percentages of YTHDF2 targets (SON, CREBBP, LDLR) in YTHDF2-bound portion vs unbound portion decreased significantly after METTL3 knockdown for 48 hours. After 24 h transfection of METTL3 siRNA, HeLa cells were transfected with flag-tagged YTHDF2, and cells were collected after another 24 h. Anti-flag beads were used to separate YTHDF2-bound portion (IP) from unbound portion 33
(flow-through). Each transcript was quantified by RT-PCR. c, Relative changes of SON, CREBBP, and LDLR mRNA in siMETTL3 sample versus siControl. d-g, Lifetimes of SON, CREBBP, and LDLR mRNA under siMETTL3 versus siControl.
Extended Data Figure 6 | Co-localization of YTHDF2 with protein markers of P bodies, stress granules, and deadenylation complexes. a-h, Fluorescence immunostaining of flag-tagged YTHDF2 (green, anti-flag, Alexa 488) and other protein markers (DCP1a and GW182 for P bodies and eIF3 for stress granule, DDX6 (also known as RCK/p54) and HuR for both, CNOT7, PAN2, and PARN for deadenylation complex; magenta of Alexa 647 is the color for the marker, green + magenta = white for the co-localization spot). The scale of the magnified region (while frame) is 1.8 μm × 1.8 μm. i, Co-localization between YTHDF2 and different protein markers were characterized by Pearson’s coefficient, for each pair, n = 5~7. YTHDF2 appears to have better co-localization with P bodies than stress granules. It also appears to co-localize best with CNOT7 (also known as CAF1 or POP2) which is a sub-unit of the CCR4-NOT deadenylation complex. j, Western blotting results showing that immunoprecipitation (IP) of flag-tagged full length YTHDF2 and N-YTHDF2 (N-terminal domain) also pulled down the p-body marker DCP2, but not with mock control or C-YTHDF2 (the C-terminal domain). For IP samples, each lane was loaded with 2 μg IP portion; and the input lane was loaded with 10 μg Input portion which corresponded to ~1% of overall input). k, Comparison of P/Q/N (highlighted) rich regions of YTHDF1-3 with other aggregation-prone proteins. l, C-YTHDF2 is capable of selective binding of m6A-containing RNA. LC-MS/MS showing that m6A-containing RNA was enriched in the His6-tagged 34
C-YTHDF2-bound mRNA while reduced in the flow-through portion. Error bars shown in the figure are mean ± s.t.d., n = 4 (two biological replicates × two technical replicates).
Extended Data Figure 7 | Tether assay of the N-terminal domain of YTHDF2. a, Structural presentation of the two domains of YTHDF2. b, Scheme of the reporter assay: the RNA reporter vector encodes firefly luciferase (F-luc) as the primary reporter and Renilla luciferase (R-luc) on the same plasmids acting as transfection control for normalization. Five Box B RNA elements were inserted at the 3’UTR of F-luc as positive tether reporter (noted as F-luc-5BoxB); the effecter was a fusion of N-YTHDF2 and λ peptide which recognizes Box B with high affinity. c, The F-luc luciferase activity (protein translation) for N-YTHDF2-λ was reduced by ~20% compared to that of N-YTHDF2 and λ controls. Error bars shown in the panel are mean values ± s.t.d. from n = 8 (biological replicates). d-e, The reporter mRNA lifetime was significantly reduced (~40%) when bound by N-YTHDF2-λ as compared to the controls of N-YTHDF2 and λ. Doxycycline (Dox, 400 ng/uL) was used to inhibit transcription of the reporter. 18 hours post transfection of reporter and effecters, Dox was removed to allow a pulse transcription of F-luc-5BoxB for 4 hours. Then Dox was added back and the samples were collected at indicated time point. The amounts of F-luc-5BoxB were determined by RT-PCR, normalized to R-luc, then for each time series, samples at t = 0 h were set as 100%. Error bars shown in the panel are mean ± s.t.d., n = 6 (two biological replicates × three technical replicates). f, Scheme of poly(A) tail length assay. g-h, tethering N-YTHDF2 to the reporter mRNA does not significant trigger deadenylation of the reporter. The PCR products of reporter poly(A) tail were visualized in 10% TBE gel stain (g) and no 35
significant difference of the deadenylation rate was observed (h). i-l, Shorter poly(A) tail lengths were observed in the YTHDF2-bound fraction for the N-YHTDF2-tethered reporter RNA (i and j) as well as the native target RNA CREBBP (k and l). Tether reporter F-luc-5BoxB and flag-tagged YTHDF2-N-λ (i) or full length flag-tagged YTHDF2 (k) were expressed in HeLa cells, and subjected to IP with anti-flag beads. RNA recovered from input, IP, and flow-through were further processed and the final PCR products for F-luc-5BoxB (i) or CREBBP (k) were visualized in 10% TBE gel. j and l, each lane were re-plotted against base pair, after log fitting of relative gel mobility with base pairs.
Extended Data Figure 8 | Cellular function of YTHDF2. a-b, The top molecular function of YTHDF2 targets is “Gene Expression and RNA Transcription”, and the top cellular function is “Cell Death and Survival”. Ingenuity Pathway Analysis of function category of YTHDF2 targets and non-targets revealed that the two gene groups are heterogeneous in their functional composition. (* top two functions for YTHDF2 targets and ** top two functions for YTHDF2 non-targets.). c-d, Pie charts of molecular types of differentially expressed YTHDF2 targets (c) versus non-targets (d) upon YTHDF2 knockdown. Differentially expressed genes (p-value < 0.05) caused by YTHDF2 knockdown were grouped to YTHDF2 targets (796 gene) and non-targets (1554) based on their presence or absence in YTHDF2 PAR-CLIP binding sites, and subject to Ingenuity Pathway Analysis (the category “other” were not shown). The results show that the group of YTHDF2 targets is transcription regulators while that of non-targets is enzyme, indicating that m6A may significantly affect gene expression via tuning mRNA stabilities of transcription factors through YTHDF2. e-f, 36
YTHDF2 knockdown led to reduced cell viability. The IPA analysis of ribosome profiling data of YTHDF2 knockdown (48 h) versus control predicts decreased cell viability (e). Ribosome profiling data was chosen since it may better reflect the translation status. MTT assay provided experimental evidence of reduced cell viability upon YTHDF2 knockdown. p-Values that calculated from Student’s t-test were 0.036, 4.7×10 -4, and 9.4×10-4, at 48 h, 72 h and 96 h respectively (f). Error bars shown in the figure are mean ± s.t.d., n = 10 (biological replicates).
Extended Data Figure 9 | Comparisons of sequencing data with replicates. a, Overlap of three biological replicates (rep1~3) for PAR-CLIP. Numbers showing the sum of genes identified in each sample. b, Correlation of enrichment fold as log2(IP/input) between two technical RIP replicates. In rep1 the input mRNA was purified by poly(dT) beads, while in rep2 the input RNA was processed by rRNA removal. c-e, Box plot showing consistent results from two biological replicates that were conducted for ribosome profiling and mRNA lifetime profiling, respectively. For mRNA lifetime profiling, rep1 was normalized by spike-in control that proportional to cell numbers, while rep2 was normalized by spike-in that proportional to total RNA concentrations. Despite the technical variations, YTHDF2 knockdown resulted in significant lifetime increase of its targets. (T, 1,277 CLIP+RIP targets; NT, 3,905 non-targets; box, the first and third quartiles; notch, the median; dot in the box: the data average; whisker, 1.5 × standard deviation; cross, the 1 and 99 percentiles; short line, the max and min; p values were calculated by Mann-Whitney U test, two tailed, significant level = 0.05). f-h, Correlation of RPKM between technical mRNA input samples prepared by 37
poly(A) selection (x axis) and by rRNA removal (y axis), which are comparable to the variations between biological replicates that prepared by the same mRNA selection method.
Extended Data Table 1 | Summary of the sequencing samples.
38
Supplementary Table 1 | Summary of processed sequencing results (PAR-CLIP, RIP, ribosome and mRNA lifetime profiling). Containing source data related to Figure 2a-d.
Category
Gene symbol
I: Non-targets. II: CLIP targets. III: CLIP+IP targets. II + III III III III III III III II
III III II III III II III II + III II III III II III II II II III III III II II + III
A4GALT AAAS AACS AADAT AAED1 AAGAB AAK1 AAMP AARS AARS2 AASDH AASDHPPT AATF ABCA13 ABCA2 ABCA3 ABCA5 ABCA7 ABCB10 ABCB6 ABCB7 ABCB8 ABCB9 ABCC1 ABCC10 ABCC3 ABCC4 ABCC5 ABCD1 ABCD3 ABCD4 ABCE1 ABCF1 ABCF2 ABCF3 ABCG2 ABHD10 ABHD11 ABHD12 ABHD13
PAR-CLIP / Peak sum
rep1
rep2
rep3
1
3
12
1 1 1
4 1
1 3 1 2
1
2 3 2
1 3 1
4
2 3 13 3
1 2 4 1 1 1 1 2 2
5 1
8 2 2
1
11 2 1
2
1
6
1 10 4
3 10 3
4 11 11 2
2 2 2
8 4
1 6 7
II II + III III II II
III II + III II + III III II III II II III III
III III III III III III III III III III III II II III III III III III III III
ABHD14B ABHD15 ABHD16A ABHD2 ABHD3 ABHD4 ABHD5 ABHD6 ABHD8 ABI1 ABI2 ABL1 ABL2 ABLIM1 ABLIM2 ABR ABRACL ABT1 ABTB2 ACAA1 ACAA2 ACACA ACACB ACAD10 ACAD8 ACAD9 ACADM ACADS ACADSB ACADVL ACAP2 ACAP3 ACAT1 ACAT2 ACBD3 ACBD4 ACBD5 ACBD6 ACCS ACD ACER3 ACIN1 ACLY ACN9 ACO1 ACO2 ACOT13 ACOT2 ACOT7 ACOT8 ACOT9
1 3 1 1
2 2 1 5 1 3
2 4
1
2 6
9 8
1 19 11 4
1 4 1 4 25 18 4
3
5
11
1 1
2 1
5 3
5
6
1
1
2
2 3 3
1
1 2
5 1 1 1
5 3
2 10 1
1 2 2 1
18 2
4 1 4 1 4
III II + III III III II II III III II II III III III II III III III II III III III
III III III III II + III III
II + III II + III III III II III III II + III
ACOX1 ACOX3 ACP1 ACP2 ACP6 ACPL2 ACSF2 ACSF3 ACSL1 ACSL3 ACSL4 ACSS2 ACTA2 ACTB ACTG1 ACTL6A ACTL8 ACTN1 ACTN4 ACTR10 ACTR1A ACTR1B ACTR2 ACTR3 ACTR3B ACTR5 ACTR6 ACTR8 ACVR1 ACVR1B ACVR2B ACYP1 ACYP2 ADA ADAL ADAM10 ADAM15 ADAM17 ADAM22 ADAM9 ADAMTS1 ADAMTS3 ADAR ADARB1 ADAT1 ADAT2 ADCK1 ADCK2 ADCK3 ADCK4 ADCY3
2
3
3
2 5
4 9 3
2
2 1 1
4
5
4 3 1
4 4
5 9
7 8
1 1 4
1
1
6
5
4 7
1 1 4 2
6 3 6 2 1
6
1
2
1 2
1 7 3
1 5 2 1
5 3
6 4 1
2 1 15 10 7
2
6
7
2
1
1 4
III II + III II + III II III III III II II + III III II II + III II + III II + III II + III III II + III
II II III III III III II II II + III III II + III II + III II III III II III III III III III III II II II II + III II + III
ADCY6 ADCY7 ADCY9 ADD1 ADD2 ADD3 ADH5 ADI1 ADIPOR1 ADIPOR2 ADK ADM ADNP ADNP2 ADO ADPGK ADPRHL1 ADPRHL2 ADRA1B ADRA2C ADRBK1 ADRM1 ADSL ADSS ADSSL1 AEBP2 AEN AES AFAP1 AFAP1L1 AFF1 AFF4 AFG3L1P AFG3L2 AFMID AFTPH AGA AGAP1 AGAP3 AGBL5 AGFG1 AGFG2 AGGF1 AGK AGL AGMAT AGPAT1 AGPAT2 AGPAT3 AGPAT5 AGPAT6
1 7 3 2 1
2 13 18 7 1
1
1
1 1 4 14 1 4 15 30 21 8 2 3 3 3 6 4 1 1
1 1 3
4 2 3
1 9 5 13
1 6
6 3
1
1
2 4 3
1 2 1 4 9 4 3
2 6 1 2 14 11 7 5
2
1
1 1 3
1 2
2
1 1 3 2 3 3
1
8 12 1 1 1 1
4 1
11 3
1 1
3 2 3
2 5 2 1 6
7 5 6 7 7
III III III II II + III III III II + III II II III II + III III II + III II + III II + III II + III III III III III II III III II III II III III II + III II + III III II + III
III III III III III III III III III III II
III
AGPAT9 AGPHD1 AGPS AGRN AGTPBP1 AGTRAP AGXT2L2 AHCTF1 AHCY AHCYL1 AHCYL2 AHDC1 AHI1 AHNAK AHNAK2 AHR AHRR AHSA1 AHSA2 AIF1L AIFM1 AIFM2 AIG1 AIMP1 AIMP2 AIP AJUBA AK1 AK2 AK3 AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP7 AKAP8 AKAP8L AKAP9 AKIP1 AKIRIN1 AKIRIN2 AKR1A1 AKR1B1 AKR7A2 AKT1 AKT1S1 AKT2 AKT3 AKTIP ALAD
1
6 2
1 5 3
2 4 1
2 6 6 1
5
5
7 8 4 5
4 2 6 15 2
7 7 8 42 4 1
1
1
4
1
1 1
1
5 2 2 8 1 1
1 3 2 10 1 4 4 14 2 1
7
18
2
3 1 1 2 5 2 1
6 2
6
2 1 1
2 1 1 3
3 1
9 3 3 4 6 7 4 2 26
1 3 3 10 6 1
II III II II + III II II III III III II II III II II + III II III III II + III III III III III II III III II + III II III III
II III III II + III III III III II + III III II + III III II + III II + III
ALAS1 ALDH16A1 ALDH18A1 ALDH1A3 ALDH1B1 ALDH3A2 ALDH3B1 ALDH4A1 ALDH5A1 ALDH6A1 ALDH7A1 ALDH9A1 ALDOA ALDOC ALG1 ALG10 ALG11 ALG12 ALG13 ALG14 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 ALKBH1 ALKBH2 ALKBH3 ALKBH4 ALKBH5 ALKBH6 ALKBH7 ALKBH8 ALMS1 ALPI ALPK2 ALPL ALS2 ALYREF AMBRA1 AMD1 AMDHD1 AMDHD2 AMFR AMIGO1 AMMECR1 AMMECR1L AMN1 AMOTL1 AMOTL2
2 2
2 2 1
5 2 4
6 1 1
3 1 2
11 9 4 1 3 1
1
1 8
1 5
1 4
1
1 2 1 1 1
1 4 3 4 2
6
11 4 1
2 1
7 1
1
1
3 4
9 1
4 1
1 1
5 5
2 6
1 8 8
4 11
1 12 8
5
1 1 1 14 2
3 1 3
2 7
1 3 8 2 12
2 6
3 6
7 16
III III II
III III III III III III III II II + III II II + III II + III II
II II III II III II
II + III II + III III III II + III
II III II III III III
AMPD2 AMTN AMZ2 AMZ2P1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ANGEL1 ANGEL2 ANKFY1 ANKH ANKIB1 ANKLE2 ANKMY2 ANKRD10 ANKRD11 ANKRD12 ANKRD13A ANKRD13B ANKRD13C ANKRD13D ANKRD16 ANKRD17 ANKRD2 ANKRD26 ANKRD27 ANKRD28 ANKRD29 ANKRD32 ANKRD33B ANKRD37 ANKRD39 ANKRD40 ANKRD46 ANKRD49 ANKRD5 ANKRD50 ANKRD52 ANKRD54 ANKRD9 ANKS1A ANKS3 ANKS6 ANKZF1 ANLN
1
2 1 6 1 12
1
2
1
2 2 2 1 1 1
2
2
1 3
1 3 1 3 3 15 5 16
1 1 3 8
1 10
2 18
4 30 3 2 2 5 2 1 17
1 1
1 1 2
3
4
1
3
2 1 2
1 5
3 10
4 24
3 1
8
1 1 1
3
2
3 2
18 6 1 1 5 7 3 8 3
4
6
2
2
1
III
III II II III II + III III III II III III III II III III III II + III III III III III III II III II III II III III III
II + III
III
II + III III II II II II
ANO10 ANO2 ANO4 ANO6 ANO8 ANP32A ANP32B ANP32E ANTXR1 ANXA1 ANXA11 ANXA2 ANXA3 ANXA4 ANXA5 ANXA6 ANXA7 AP1AR AP1B1 AP1G1 AP1M1 AP1M2 AP1S1 AP1S2 AP1S3 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 AP3B1 AP3D1 AP3M1 AP3M2 AP3S1 AP4B1 AP4E1 AP4M1 AP5B1 AP5M1 AP5S1 AP5Z1 APAF1 APBA3 APBB2 APBB3 APC APEH APEX1 APEX2 APH1A
1
1 1 2 4
2
1 1
6 4
3 2 1 10
3 1 4 3 2 16
1
2 2
2 1 2 5
3
2
1 1 1
1 1 6 1 1 1
1
1 2 1 2 12 1 1 3 2 3 3 6 2 1 1 4 5 4
1 19
2 2 39 3
1
1
1
3
1 6
1 1 2 1
1 1 3 6 5
7 4 6 14 12
9 2
III III III II III III III II III III II
II III II III III III II II III III II II + III II + III II III II + III II + III III II III III II II III II
II II + III
III II + III II + III
API5 APIP APLP1 APLP2 APOA1BP APOBEC3C APOL2 APOO APOOL APOPT1 APP APPBP2 APPL1 APPL2 APRT APTX AQP3 AQR ARAF ARAP1 ARAP3 ARCN1 ARF1 ARF3 ARF4 ARF5 ARF6 ARFGAP1 ARFGAP2 ARFGAP3 ARFGEF1 ARFGEF2 ARFIP1 ARFIP2 ARFRP1 ARG2 ARGLU1 ARHGAP1 ARHGAP10 ARHGAP11A ARHGAP11B ARHGAP12 ARHGAP17 ARHGAP18 ARHGAP21 ARHGAP23 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP32 ARHGAP35
2
1 2
3
2 1
1 3 3
4
9
3 1
5 2 1 2 1 3
1 1 1 3 1
2 4 6 2 2
6 4 1 1 2 3 2 4 2 10 6 8
1 1
6 5 3 1 1 11 16 1 2 2 1
2
1
1 1
2 2
5 10
3
6
11
1 1 5 10 1
1 1 3
3 9
3 3 4 3 1
5 11
2 11 27 2 1 1 3 2 6 2
1 5 5 15 13 3 3 1 9 26
III II + III II III
III II + III III II + III II III III III
II II + III II + III II + III III III II II + III III III III III III III III
II + III III II III II III III III III II II
ARHGAP39 ARHGAP44 ARHGAP5 ARHGDIA ARHGEF1 ARHGEF10 ARHGEF10L ARHGEF11 ARHGEF12 ARHGEF16 ARHGEF17 ARHGEF18 ARHGEF19 ARHGEF2 ARHGEF25 ARHGEF3 ARHGEF4 ARHGEF40 ARHGEF7 ARHGEF9 ARID1A ARID1B ARID2 ARID3A ARID4A ARID4B ARID5B ARIH1 ARIH2 ARL1 ARL13B ARL15 ARL16 ARL2 ARL2BP ARL3 ARL4D ARL5A ARL5B ARL6 ARL6IP1 ARL6IP4 ARL6IP5 ARL6IP6 ARL8A ARL8B ARMC1 ARMC10 ARMC4 ARMC5 ARMC6
1 5 3
6 6
2
4 1
2 4
5 3 1
3 2 12 5 2
2 6
1 1 5 6 1 13 9 2 2
1 1 18 2 7 1 1 1 9 2 1
2 2 10 1 44 18 16 2 1 6 21 7 4
1
2 1
1 1
1
3
1 1 2
2
1 4
4 1 15 11
3 1 1 2 1 3
2
1 1 6
2
2 2 2
1 3
6 5
II + III III
III III III III III III II II + III III III III II II + III II + III III III III II III II + III
III II II + III III II II + III III III III III III III II II
ARMC7 ARMC8 ARMC9 ARMCX3 ARMCX6 ARNT ARNTL ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ARPC5L ARPP19 ARRB1 ARRB2 ARRDC1 ARRDC2 ARRDC3 ARSB ARSG ARSK ARV1 ARVCF ASAH1 ASAP1 ASAP2 ASAP3 ASB1 ASB13 ASB6 ASB7 ASB8 ASB9 ASCC1 ASCC2 ASCC3 ASF1A ASF1B ASH1L ASH2L ASIC1 ASL ASMTL ASNA1 ASNS ASNSD1 ASPH ASPHD1 ASPM
3 3
2
5 4
2
2 4
1
3
1 4
1 3 3 3
2 5
1 2
2
4
6 3 5 6 4 1 2 1 11 4 3 3
1
1 1
1
3 1
4 3
1 1 4 7 2
2
8 13 3 4
1 3
1 3
2 2
2 5
5 7
6 16 1 3
1
1
2 1
1 2 2
2 2 2 2 2 4
III III III II + III II + III III
II III III III II III II II III II II + III
II III III III II III II + III III II III II II + III II III II + III
II III
ASPSCR1 ASS1 ASTE1 ASUN ASXL1 ASXL2 ATAD1 ATAD2 ATAD2B ATAD3A ATAD3B ATAD5 ATE1 ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF6B ATF7 ATF7IP ATG10 ATG12 ATG13 ATG14 ATG16L1 ATG2A ATG2B ATG3 ATG4A ATG4B ATG4C ATG4D ATG5 ATG7 ATG9A ATIC ATL2 ATL3 ATM ATMIN ATN1 ATOX1 ATP10D ATP11A ATP11B ATP11C ATP13A1 ATP13A2 ATP13A3
9 5
18 6
2 4 1 1 30 17
1
1 2 2
5 2
6 1
1 1 2 3 3 1 2
2 4 1 2 5 1 4 4
2 1 8 6 17 8 3 5 6
1 5 1 2 1 1
4 8
1
1
3
1
3
5
6
6 2 5
5 3
3 4 1 9 8
5 4 1 23 24
13
22
1
1 3 1
1
1 2 3
1
2
1 23 1 1 1 2 1
II II II II II + III
III III II III III III III III III III III III III III III III II II III II II II III II III
III III III III III III
II II + III III III III III
ATP1A1 ATP1A1OS ATP1B1 ATP1B3 ATP2A2 ATP2A3 ATP2B1 ATP2B4 ATP2C1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP5S ATP5SL ATP6AP1 ATP6AP2 ATP6V0A1 ATP6V0A2 ATP6V0B ATP6V0C ATP6V0D1 ATP6V0E1 ATP6V0E2 ATP6V1A ATP6V1B2 ATP6V1C1 ATP6V1D ATP6V1E1 ATP6V1F ATP6V1G1 ATP6V1H ATP7A ATP7B ATP8B1 ATP8B2 ATP9A ATP9B ATPAF1 ATPAF2 ATPBD4
1 4 4 10 1 3
5 1 5 5 14 4 2
2 6 4 13 3 7 3 1
1 1
2 3 1
2 2
3 1 4 2 1 2 1 1
2 1 1 5 1 2 2 7 3
7 2 4 3 3 3 5 1 2 1
3 2
1 1 2 1 8 1 1 2 1 6 3 5 1 3
1 1
1
1 1 9
3 11
2 3 1 7 18 1 1
III
II + III II II II II + III III II III II III II III II III III III II + III II II + III II III II II II II + III II II + III II + III III II II II II II + III II + III III III II II + III
ATPIF1 ATR ATRIP ATRN ATRX ATXN1 ATXN10 ATXN1L ATXN2 ATXN2L ATXN3 ATXN7 ATXN7L1 ATXN7L2 ATXN7L3 ATXN7L3B AUH AUP1 AURKA AURKAIP1 AURKB AVEN AVL9 AVPI1 AXIN1 AXIN2 AXL AZI1 AZI2 AZIN1 B2M B3GALNT2 B3GALT6 B3GAT3 B3GNT1 B3GNT2 B3GNT9 B3GNTL1 B4GALNT1 B4GALNT4 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT7 B9D1 B9D2 BABAM1 BACE1 BACE2
1 2 2 1 1 3 2
4 1 2 1 9 1 6
1
2 1
1 4 5 7 2 23 4 10 1 9 5
3
4 4
4 1 1
3
12 9 3 4 4 2 1
4 1 2
2 1 1
1 5 7
2
4
1
1 1 3
3 2
2 3 3 4 11 2 3 6 1
4 8 6 2 19 2 3 7 10
1 1 12 1 2
1 12 5 3
3 3
7 2
1 4
1 3 11
7 1
2 7 16 7 5 1 11 5 1 2 13 17
II + III III III III
II + III II II II + III III II II II + III II III II II + III II II II II II III III III
III III II III II II II + III II + III III III III II II III III III III II
BACH1 BAD BAG1 BAG2 BAG3 BAG4 BAG5 BAG6 BAHCC1 BAHD1 BAI2 BAIAP2 BAIAP2L1 BAK1 BAMBI BANF1 BANP BAP1 BARD1 BASP1 BATF3 BAX BAZ1A BAZ1B BAZ2A BAZ2B BBIP1 BBS1 BBS10 BBS2 BBS4 BBS7 BBS9 BBX BCAM BCAP29 BCAP31 BCAR1 BCAR3 BCAS2 BCAS3 BCAS4 BCAT1 BCAT2 BCCIP BCKDHA BCKDHB BCKDK BCL10 BCL2L1 BCL2L11
1
4
7 1
1 2 2 1
3 3 3 5 3 4 2
5 1 2 1 1 1 1 6
1 2 3 2 1 1 1 12
2 1 1 4
3 1 5 5
7 7 7 2 18 8 2 1 4 4 5 4 7 1 10 4 4 11 13 1 1
1
2
3
1 1 9 2
2 5 10 1
8 2 2 4 24 3 2
1 1 1
3
6 3
2 3
4 2 2 1 8 4 8 1
II II + III III III III II + III II III II + III II II II + III II III III III III III II II + III III II + III
II + III II III III
III II + III II III II II III III III III
II + III II + III III III III III
BCL2L12 BCL2L13 BCL2L2 BCL3 BCL6 BCL7A BCL7B BCL7C BCL9 BCL9L BCLAF1 BCOR BCORL1 BCR BCS1L BDH1 BDH2 BDP1 BECN1 BET1 BET1L BFAR BFSP1 BHLHE40 BHLHE41 BICC1 BICD1 BICD2 BID BIN1 BIN3 BIRC2 BIRC5 BIRC6 BLCAP BLM BLMH BLOC1S2 BLOC1S3 BLVRA BLVRB BLZF1 BMP1 BMP2K BMP4 BMP6 BMPR2 BMS1 BNIP1 BNIP2 BNIP3
1 1
2 2 1 17 1 5 1 2
1 4 3 1 2 5 3 2 29 4 5 3 1
2 13 3 1 3 12 4 1 14 51 5 13 5 4 3 2
2
4 1
5 1
6 4
15 8
6
4 1 1 3 4
15 5
3 2
3 1
3 5 2 2
2 2
1 4
9 9 1 4 2 3 12 9 2 2 4 6
1
2 1 1
3 3
2 2 13 2 5 7 2 1 4
III III III
III III
III III II
III III II + III II II II III II III III II III II + III III III III III III III III II III
II II II III III III
BNIP3L BOD1 BOD1L1 BOK BOLA1 BOLA3 BOP1 BORA BPGM BPHL BPNT1 BPTF BRAF BRAP BRAT1 BRCA1 BRCA2 BRCC3 BRD1 BRD2 BRD3 BRD4 BRD7 BRD8 BRD9 BRE BRF1 BRF2 BRI3 BRI3BP BRIP1 BRIX1 BRK1 BRMS1 BRMS1L BROX BRP44 BRP44L BRPF1 BRPF3 BRSK2 BRWD1 BRWD3 BSDC1 BSG BST2 BTAF1 BTBD1 BTBD10 BTBD2 BTBD3
1
2
1 1
1 5
1
1
1 5 1 2
1 8 1 4 1 1 2 1 2 1 3
2 1 16 4 10 1
1 4 1 1
2
15 1 1 6 1 2 5 3 34 1 15 2 3 3 3 2 9 1 3 1 1 1
6
3 3 1
8 9 2
1 9 5
2 4 4
7 2 4 2 3
1 1 2
5 11
II + III
III III II + III III II + III II + III II + III II + III
III II III II + III III III III
III III II + III III III III III II
III III III III III III
III III III
BTBD6 BTBD7 BTBD9 BTD BTF3 BTF3L4 BTG2 BTG3 BTN2A1 BTN3A1 BTN3A2 BTN3A3 BTRC BUB1 BUB3 BUD13 BUD31 BYSL BZW1 BZW2 C10orf114 C10orf118 C10orf12 C10orf125 C10orf137 C10orf2 C10orf32 C10orf35 C10orf47 C10orf57 C10orf76 C10orf88 C11orf1 C11orf10 C11orf2 C11orf24 C11orf30 C11orf31 C11orf46 C11orf48 C11orf49 C11orf54 C11orf57 C11orf58 C11orf63 C11orf67 C11orf68 C11orf71 C11orf73 C11orf74 C11orf75
3 2 2 1 2 1 1 3 1
1 1
2
1
2 8 1
1
10 10 6 1 2 1 3
7 6 2 2 4
6 7 10 3 5
2 2
1 5 1 8 5
2 1 1 1
1 2 1
2
5
5
3
1
1
1 2 1
1 9 4
1 1
2
1
4 2
4
1
3
1
2 1
2
1
II + III III III
III
II III II + III
III III II + III III III II
II + III III III II + III
III II + III III II + III III II II + III III II II + III II + III III II
C11orf82 C11orf83 C11orf84 C12orf10 C12orf23 C12orf26 C12orf29 C12orf32 C12orf35 C12orf4 C12orf43 C12orf44 C12orf45 C12orf49 C12orf5 C12orf51 C12orf52 C12orf57 C12orf65 C12orf66 C12orf73 C12orf75 C12orf76 C14orf1 C14orf101 C14orf102 C14orf109 C14orf118 C14orf119 C14orf126 C14orf129 C14orf133 C14orf135 C14orf142 C14orf149 C14orf166 C14orf169 C14orf2 C14orf43 C14orf79 C14orf80 C14orf93 C15orf23 C15orf29 C15orf39 C15orf40 C15orf41 C15orf42 C15orf44 C15orf52 C15orf57
1
3
6
1 1 2
3
2 2 1 1 5
3 7 2 2 5
4 1
7 4 1 4
1
2 1
2 2
2
2
1 1 3 1 1 7 1
1 1 1
1 1 2
1 1
2 2
1 1 1 5 1 2 2 1 6
1
2
7 1 1 2 3 1 8 1 1
1
3
15
20
1 3 1
1 6 4
4 1 38 1 1 12 8
1
1
2
III III III II II III III III II + III III II + III II + III III III III II + III III II + III II + III II III III III III II II + III II III II + III II + III III III II II III
II
C15orf61 C16orf13 C16orf45 C16orf5 C16orf55 C16orf57 C16orf58 C16orf59 C16orf62 C16orf7 C16orf70 C16orf72 C16orf74 C16orf80 C16orf87 C16orf88 C16orf91 C16orf95 C17orf101 C17orf108 C17orf39 C17orf48 C17orf51 C17orf53 C17orf56 C17orf58 C17orf59 C17orf62 C17orf65 C17orf70 C17orf75 C17orf79 C17orf80 C17orf81 C17orf85 C17orf89 C17orf90 C17orf96 C17orf97 C18orf21 C18orf25 C18orf54 C18orf56 C18orf8 C19orf10 C19orf21 C19orf24 C19orf25 C19orf26 C19orf40 C19orf42
1 2 1 6
1 1
2 3 8
5 6
1 9 2
1 3 11
3 9 19 2
1 1 2
3 1
1 7 3 2
4
1 10 1 1
1 7
3 9
3
2
1 2 26 4
2 8 1 3
3 1
4 2 3
1 1 2
2 2 1
3 14 2
3 1
3 1
4 3
3 1 5
4 1 3
1 1 4 1
4
3
1
II II + III II II II III III II III III III III
II II II II
III III III III III II II III II + III II II III III III
III III II + III II II II + III
C19orf43 C19orf44 C19orf47 C19orf48 C19orf52 C19orf53 C19orf54 C19orf55 C19orf57 C19orf6 C19orf60 C19orf70 C19orf71 C1D C1GALT1 C1GALT1C1 C1QBP C1QL1 C1QTNF6 C1R C1RL C1S C1orf109 C1orf112 C1orf115 C1orf122 C1orf123 C1orf131 C1orf133 C1orf135 C1orf144 C1orf159 C1orf174 C1orf198 C1orf212 C1orf216 C1orf233 C1orf27 C1orf31 C1orf35 C1orf43 C1orf50 C1orf52 C1orf53 C1orf56 C1orf63 C1orf74 C1orf85 C1orf86 C1orf9 C20orf11
1 1 1 5 2 1
4 6 3 6
9
15
1 2
5 14 1 14 3 2 9 3 15
1
1 3 1 1 1
1 1 4 1 3
1
1
2 1
2 5 1
1 1
1 1 1 1
5 4
7 10
1 2 3 1 2
5 3 10 3 2
6 1 1 1 1 1 1 1
1 3 8 1 9 2 5 1
3 3 1 2
3 2 1 2 5
8 3 5 5 9
II II + III III III II + III III
III III III II + III III II III II II + III III
III II + III II III III
II + III III
II III III III II + III III II + III III III III III III III II + III III
C20orf111 C20orf112 C20orf20 C20orf27 C20orf3 C20orf4 C20orf43 C20orf72 C20orf94 C20orf96 C21orf119 C21orf2 C21orf33 C21orf58 C21orf59 C21orf91 C22orf13 C22orf25 C22orf28 C22orf29 C22orf32 C22orf39 C22orf40 C2CD2L C2CD3 C2orf18 C2orf28 C2orf29 C2orf42 C2orf43 C2orf44 C2orf47 C2orf49 C2orf56 C2orf68 C2orf69 C2orf70 C2orf74 C2orf76 C2orf89 C3 C3orf17 C3orf18 C3orf19 C3orf23 C3orf26 C3orf37 C3orf38 C3orf52 C3orf58 C3orf72
1
2
4
2
2 3
6
9
4 1 3 17 3
1
1 1
2 2
1 8
1
2 2
11
2 3
2 5
1 2 3 1
2 8 1 1
2 9 1 2 5 2 3 16 2 1 1 6
3
1
1
1 1
1 2 2 1
1
1
7
11
2
2 1 1
6 1 1
1 1
2
2
2 2 5
3
8
III III III III III III III III III
II + III II II + III II II + III II
III II III II III II + III III II III
III III III II + III II + III II III III II + III III III
C3orf75 C3orf78 C4BPA C4BPB C4orf21 C4orf27 C4orf29 C4orf3 C4orf32 C4orf33 C4orf34 C4orf48 C4orf52 C5 C5orf15 C5orf22 C5orf24 C5orf25 C5orf28 C5orf30 C5orf34 C5orf42 C5orf43 C5orf44 C5orf45 C5orf51 C5orf54 C5orf55 C5orf62 C6orf1 C6orf106 C6orf108 C6orf120 C6orf130 C6orf136 C6orf162 C6orf203 C6orf211 C6orf223 C6orf225 C6orf226 C6orf228 C6orf47 C6orf48 C6orf57 C6orf62 C6orf70 C6orf72 C6orf89 C6orf99 C7orf10
1
1
2
1 2 1 1 1 1 1
3 2 2 4 2 1 2
4 12 9 8 4 3 2 3 2
2
7 3 2 1 1 16
1
1
1
1 6
1
1
1
1 1
4 1 2 1 5 1
1 3 1
2
2 3 1
7 5 1
3
10
5
6
III II III II + III II III III II
III III III II III II II III
II III
II + III III III II III III III II III III III
III
II + III
C7orf13 C7orf23 C7orf25 C7orf26 C7orf43 C7orf49 C7orf50 C7orf59 C7orf73 C8orf33 C8orf37 C8orf4 C8orf40 C8orf58 C8orf59 C8orf82 C9orf100 C9orf114 C9orf116 C9orf123 C9orf142 C9orf156 C9orf16 C9orf169 C9orf3 C9orf37 C9orf40 C9orf41 C9orf64 C9orf69 C9orf72 C9orf78 C9orf85 C9orf86 C9orf89 C9orf9 C9orf91 CA11 CA5B CA5BP1 CAB39 CAB39L CABIN1 CABLES1 CABLES2 CABP4 CACFD1 CACHD1 CACNA2D1 CACNA2D3 CACNB3
2
2
2 2
5 2
1
2
4
2
3
2
6
1
2
1 1 8
2 1
1 1 1 1
1 1 2 2
1
2
3 3 3
10
9
16
2 2
1 1 6
3
11
2
5 9
3
1 2 1
6 1 4 8 1
1
1
2 2 3
3 2 3 3 2 1 3
III II III III III II II III III II II III II + III III II + III III II + III II + III III III III II + III II III III III III III II II II III III II III III III III III II
CACYBP CAD CADM1 CADM4 CALCOCO1 CALCOCO2 CALD1 CALM1 CALM2 CALM3 CALML4 CALR CALU CAMK1 CAMK1D CAMK2G CAMK2N1 CAMK4 CAMKK1 CAMKK2 CAMKMT CAMLG CAMSAP1 CAMSAP2 CAMSAP3 CAMTA1 CAMTA2 CAND1 CANT1 CANX CAP1 CAP2 CAPG CAPN1 CAPN10 CAPN2 CAPN7 CAPNS1 CAPRIN1 CAPRIN2 CAPZA1 CAPZA2 CAPZB CARD10 CARD8 CARHSP1 CARKD CARM1 CARS CARS2 CASC3
1
3 2
1 2 4
5 1 1
1 1
5 2 3 4 3 11 12 1 2 6
8 7
1 13 8
1
2 2
1
1
6 1 1
1 1
1 7
5 15
1 3 3 16 16 2 1
2 3 4 16 11 4 3
9 7
2 1
3
2 1
2 4 4
3
1 2 1 1 3
1
2
4 6 2 5 1 6 4 1 2 1 7 1 3 1 5
II II
II III III III
II III II III II + III III
III III III II III III II + III III II + III II II III III II III III II III III III III III III III III III III
CASC4 CASC5 CASK CASKIN2 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CAST CAT CAV1 CAV2 CBFA2T2 CBFB CBL CBLB CBLL1 CBR1 CBR3 CBR4 CBS CBWD1 CBX1 CBX2 CBX3 CBX4 CBX5 CBX6 CBX7 CBX8 CBY1 CC2D1A CC2D1B CC2D2A CCAR1 CCBL1 CCBL2 CCDC101 CCDC102A CCDC104 CCDC106 CCDC109B CCDC111 CCDC112 CCDC113 CCDC115 CCDC117
1 1
1
1 5 1 2 3
1 2 2 2
2 2 1
5
3
1
5 8 3 1
2 11 2 7 8 1
1 4 6
3
1 1 7 1 11 2 8
4
9
3
5
1 10 1 7 7 8
6 24
1
14 12 14 1 3
1
1
2 4
1 1
1
2
1
1
III III III III
II II III III III III III III II III III III II III II III II III III III III III II + III III III III III III III III II II III III III III
CCDC12 CCDC120 CCDC124 CCDC125 CCDC126 CCDC127 CCDC130 CCDC132 CCDC134 CCDC137 CCDC138 CCDC14 CCDC159 CCDC163P CCDC167 CCDC169 CCDC18 CCDC22 CCDC23 CCDC24 CCDC25 CCDC28A CCDC28B CCDC34 CCDC41 CCDC43 CCDC47 CCDC50 CCDC51 CCDC53 CCDC56 CCDC57 CCDC58 CCDC59 CCDC6 CCDC64 CCDC66 CCDC69 CCDC71 CCDC75 CCDC77 CCDC80 CCDC82 CCDC84 CCDC85B CCDC85C CCDC86 CCDC88A CCDC9 CCDC90A CCDC90B
1 1
1 1 1
1
4 1 3
2 2 2 5 4
2
5 6 3 3
1
3
1 1 1 1
1
2 1
2
1
2
1
5
2 1 1
1
1
3 2
1 1 4 1 3 1
1 2 9 3 2 3
11 4 1 3
2 1 3 18 5 1 5 1
III II II III III III III III II III III III II II III III III II II III III II II II
II + III II + III III II + III III III III II II II III III II III III III II II II III
CCDC91 CCDC92 CCDC93 CCDC94 CCDC97 CCDC99 CCHCR1 CCL2 CCM2 CCNA2 CCNB1 CCNB1IP1 CCNB2 CCNC CCND1 CCND3 CCNDBP1 CCNE1 CCNE2 CCNF CCNG1 CCNG2 CCNH CCNI CCNJL CCNK CCNL1 CCNL2 CCNO CCNT1 CCNT2 CCNY CCP110 CCRN4L CCS CCT2 CCT3 CCT4 CCT5 CCT6A CCT6P1 CCT6P3 CCT7 CCT8 CCZ1 CCZ1B CD151 CD164 CD24 CD276 CD2AP
1 1
1 1 3 3
1 2 3 5 7 1 1 2
2
1 2 2
2 1
5 2
5 2
3 1
4 2
13 3
1
5 2 1 3 1
1 4
6 1 1
1 6 5 2 4
2 6 1
12 2
2
2
6 21 5 1 4 10
3 1 2 5 2
2 5 5 5 2
2 2
1
1
1
3 2
1 5
2
8 1
2 4 2 14
3 5 3 1 1
II II II III II II III II II III II II + III II II III II + III III III III II II II III III II II II III III III II II II II + III II + III II III III III III III II + III II III
CD2BP2 CD320 CD44 CD46 CD47 CD55 CD58 CD59 CD63 CD81 CD82 CD83 CD9 CD97 CD99 CD99L2 CDA CDADC1 CDAN1 CDC123 CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC26 CDC27 CDC34 CDC37 CDC37L1 CDC40 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42SE1 CDC42SE2 CDC45 CDC5L CDC6 CDC7 CDC73 CDCA2 CDCA3 CDCA4 CDCA5 CDCA7
3 2 7 1 5 5 1 3 1 9 1 8 1
3 2 11 2 1 11 2 2 3 1 1 8 3 14 1 6 1
11 3 17 2 3 5 5 6 2 3 14 3 20 5 1
2
6
3
3
2 3
5 1
5 2 10 4 1
1 3 1
4 4 4
1 1 2 1
1 1 3 2
3 2
7 10
2
1 1 1 3
3 6 1
11 8 3
1 6 5 13 8 5 13 8 1 1 5 2 3 2 4 11 1
III III III III III II III II + III II + III III III II III III III III III III III II + III III II III II II III II III II + III II + III III III
II II II + III II + III II + III II + III II + III
CDCA7L CDCA8 CDH2 CDH24 CDIPT CDK1 CDK10 CDK11A CDK12 CDK13 CDK16 CDK17 CDK18 CDK19 CDK2 CDK20 CDK2AP1 CDK2AP2 CDK4 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK6 CDK7 CDK8 CDK9 CDKAL1 CDKL1 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2AIP CDKN2AIPNL CDKN2B CDKN2C CDKN2D CDKN3 CDON CDR2 CDR2L CDS2 CDT1 CDV3 CDYL CDYL2 CEBPA CEBPB CEBPD CEBPG
4 1
1 1 3 2
1
3 1 1
7 1 1 6 3
9 7 3 1
23 17 8 4
1 4
2 10
1
1
3 1 11 1
2
5 1
2
2
1 1
1 2 4
5 2 1 2 7
1
1 1
4 3
2 4
3 3
5 7 2
2
1 2 1
3 4 3 1 10 1 2
1 6 2 4 4 12
5 9 1 3 20 2 8 6 17
1
3
II + III III II II + III II + III II + III II + III III III II III II III III II II + III III III III III II III III III III
III III
III III III III III III II + III
CEBPZ CECR5 CECR7 CELF1 CELSR1 CELSR2 CELSR3 CENPA CENPB CENPBD1 CENPC1 CENPE CENPF CENPH CENPI CENPJ CENPK CENPL CENPM CENPN CENPO CENPP CENPQ CENPT CENPV CENPW CEP104 CEP112 CEP120 CEP128 CEP135 CEP152 CEP164 CEP170 CEP170P1 CEP19 CEP192 CEP250 CEP290 CEP350 CEP41 CEP44 CEP55 CEP57 CEP57L1 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78
1 1 1 16 11 3 1 6 2
1 1 2 16 13 10 9
7
6
1
2 1
1 4
2 6
4 3 2 8 27 21 24 1 15 1 1 1 9 2 2 1 3 3 7 19 2 1 2
2 1
5 3
1
1 3
4 1 6 1 1 2 2 1 3 4
1
2
1
2 3
2 1
1 1
2 3
4
11
III III II + III II II II III II II III III III III III III II II
II + III III II III II + III III III III II III III II II III III II II II II + III II + III II + III II + III II + III III III II III II
CEP85 CEP89 CEP95 CEP97 CEPT1 CERCAM CERK CERS2 CERS4 CERS5 CERS6 CES2 CETN2 CETN3 CFD CFDP1 CFL1 CFL2 CFLAR CGA CGGBP1 CGRRF1 CHAC1 CHAC2 CHAF1A CHAF1B CHAMP1 CHCHD1 CHCHD10 CHCHD2 CHCHD3 CHCHD4 CHCHD5 CHCHD6 CHCHD7 CHCHD8 CHD1 CHD1L CHD2 CHD3 CHD4 CHD6 CHD7 CHD8 CHD9 CHDH CHEK1 CHEK2 CHERP CHIC2 CHID1
1 1 1 6 4 3 1
1 4
8
4 2 1 1 1 1 2 11 2 4 1 8
3 1 1 7
8 4 2 3 2 2 2 18 3 8 2 11 2
1 2 5 5
2
8 1 3
9 1 5
2
6
10
1 1
3
1 9 1
1 1 1
4 1 4 1 3 1 2 1
7 1 1
1 2 2 1 7 5 2 6 3 4 4 2 1 4 1 2
1 2 1 7 1 11 5 2 8 11 7 18 2 2 16 1
II II + III II II + III III III III III III III III
III III II + III II + III III III
II + III II + III II + III II + III II + III II + III III II + III
II III III III III III III III III III
II
CHKA CHM CHML CHMP1A CHMP1B CHMP2A CHMP2B CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CHMP6 CHMP7 CHN1 CHORDC1 CHPF CHPF2 CHPT1 CHRAC1 CHRNA5 CHRNA9 CHRNB1 CHST10 CHST11 CHST12 CHST14 CHST15 CHST3 CHSY1 CHTF18 CHTF8 CHTOP CHUK CIAO1 CIAPIN1 CIB1 CIC CIDEB CILP CINP CIR1 CIRBP CIRH1A CISD1 CISD2 CISD3 CISH CIT CITED2 CITED4
1 1 10 1 2
2 1 15 4 2 1 1 1
2 25 10 3 1 1 3
1
4 4 1
6 7 1
3 2 6 12 6 7 10
13 15 2 1 1 1 1 6 3 8 14 6 22 9
5
13 3
17 4
2
4
1
6 4 1
1 4 3 7 4 4 3
2 1 1 1 1 2 1 1 2
4
1
4 6 1 7 1 4 1 1 2 1 1 7 2 2 8
II III II + III II II III III III
III III III II + III II + III II II III
III III III II
III III III III II + III III II III
II III II II III III II III II III II + III
CIZ1 CKAP2 CKAP2L CKAP4 CKAP5 CKB CKLF CKS1B CKS2 CLASP1 CLASP2 CLASRP CLCC1 CLCN2 CLCN3 CLCN4 CLCN6 CLCN7 CLDN12 CLDN7 CLDND1 CLEC16A CLGN CLIC1 CLIC4 CLINT1 CLIP1 CLIP2 CLK1 CLK2 CLK3 CLK4 CLMP CLN3 CLN5 CLN6 CLNS1A CLOCK CLP1 CLPB CLPP CLPTM1 CLPTM1L CLPX CLSPN CLSTN1 CLSTN3 CLTA CLTB CLTC CLTCL1
1
2 2
1
5 2 1 7 2 2 1 3 2 4 1 1 1
2 4 2 1
2 3 1
2 1 2 5 3
2 3 8 10 3
3 2 3
1 1 1 5
2
1 1 1 1 4
2
2 1
1 1 2
2 6 3 2 6 6 6 3 1 1 6
2
4
3
4 2 7 4
9 2 5 2 10 1 7 8
5 2 2 1 8
3 9 4 2 2 6
4 7
6 2 2
II III III III III III II III II III III III II III II III III II + III III
II + III III II III II + III II III II II II II III II + III III III III III III II + III II II II + III
III III
CLU CLUAP1 CMAS CMBL CMC1 CMC2 CMIP CMPK1 CMTM3 CMTM4 CMTM6 CMTM7 CMTM8 CNBP CNDP2 CNEP1R1 CNIH CNIH4 CNKSR3 CNN2 CNNM2 CNNM3 CNNM4 CNO CNOT1 CNOT10 CNOT2 CNOT3 CNOT4 CNOT6 CNOT6L CNOT7 CNOT8 CNP CNPPD1 CNPY3 CNPY4 CNST CNTLN CNTNAP1 CNTROB COA5 COASY COBL COBLL1 COBRA1 COG1 COG2 COG3 COG4 COG5
5
4
2
1
3 1
4
4
5
1
1 1
2 2
2
2
1
2 3 1
6
6 3
1 1
1 2 1 2
6 1 2 2 1 4 2 1 2 1 2 7
1
3
2 1 3 1
1 4 2 1 4 3 3 2 14 2 8 3 4
3 6 8 5 4 2 6 3 7 1 5 1
1
3
1 1 1 1 2
4 5 1 3 6 1
3 1 1 2
1 4
III
III II III II
II II III III III III III II III III III III III III II II II III
III III III III III II III II III III III III III III III III III III
COG6 COG7 COIL COL12A1 COL16A1 COL18A1 COL1A1 COL4A1 COL4A2 COL4A3BP COL4A5 COL5A1 COL7A1 COL9A3 COMMD1 COMMD10 COMMD2 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 COMMD9 COMT COMTD1 COPA COPB1 COPB2 COPE COPG1 COPG2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPZ1 COPZ2 COQ10A COQ10B COQ2 COQ3 COQ4 COQ5 COQ6 COQ7 COQ9 CORO1B
2
2
3
11 4
1
1 1 2
2 1 1 2 1
4 4 4 5 4
12 3
16 4
1
1 1
1
1 1 2 1 1
1 1 2 2 4 2 1
3 1 1 2
4 2
1 4 3 4 1 1 1 11 2
1 1 1 1
2
1 1 1 3
1
5
8
1
2 1 1
3
2 2
1
1 1
2 7
III III III III III III III III III III III II III III III III III III II III II + III II + III III II III III II + III III III III III III II + III III III III III II III III III
CORO1C CORO2A COTL1 COX10 COX11 COX14 COX15 COX17 COX18 COX19 COX20 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2 COX7A2L COX7B COX7C COX8A CPA4 CPD CPEB1 CPEB2 CPEB4 CPNE2 CPNE3 CPNE7 CPNE8 CPOX CPPED1 CPS1 CPSF1 CPSF2 CPSF3 CPSF3L CPSF4 CPSF6 CPSF7 CPT1A CPT2 CPVL CPZ CRADD CRAMP1L CRAT CRBN CRCP CREB1
1 1 3
8 2 5 3
3
1 5
2 1 1
3
4 1 1
3 3 1
1
3
3
1
2
4
1
1 3
2 7 1 2 3 1 1 1 4
1 2 1
1 1
6
12 1
2
1 1 1 6 4
1 1 1 4
2 1 1 2 2
1 1 1 3 2 19 5 3 2 9 2 4 5
III II III II + III II + III II III III II + III III III III II + III II + III III III III III III III III II II II + III III III III III III II III III II II II + III
III II II II
II II III
CREB3 CREB3L2 CREB3L4 CREBBP CREBL2 CREBZF CREG1 CRELD1 CRELD2 CREM CRIM1 CRIP1 CRIP2 CRIPT CRK CRKL CRLF1 CRLF3 CRLS1 CRMP1 CRNDE CRNKL1 CROCCP2 CROT CRTAP CRTC2 CRTC3 CRY1 CRY2 CRYBB2P1 CRYL1 CRYZ CRYZL1 CS CSAD CSDA CSDE1 CSE1L CSF1 CSGALNACT1 CSGALNACT2 CSK CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 CSNK2A1 CSNK2A2 CSNK2B
5
9
8
4
11 2 8 3 1 2
12 3 15 2 1 1 1 8
6 2
1 3
6
1 4 4
10 7
14 24
1
5 1 2
1
1 4
4 5 11
8 7 23
1 1
1
11
2 2 3
2 2 6 7 2
1 2 5 1 1 1 1 1
2 8 2 2 1 3 1 2
1 11 2 5 3 15 2 4 1 3 25 9 5 4 5 7 2
III II + III II + III II III III III II + III III II + III III III II II + III III II II II II
II + III II II III II + III III III II III II II II III III III II II
III III III
CSPG5 CSPP1 CSRNP1 CSRNP2 CSRP1 CSRP2 CST3 CSTB CSTF1 CSTF2 CSTF2T CSTF3 CTAGE5 CTBP1 CTBP1-AS1 CTBP2 CTBS CTC1 CTCF CTDNEP1 CTDP1 CTDSP1 CTDSP2 CTDSPL CTDSPL2 CTGF CTH CTIF CTNNA1 CTNNAL1 CTNNB1 CTNNBIP1 CTNNBL1 CTNS CTPS2 CTR9 CTSA CTSB CTSC CTSD CTSF CTSL1 CTSL2 CTSZ CTTN CTTNBP2 CTTNBP2NL CTU1 CTU2 CUEDC1 CUEDC2
4 9 2 4
11 4 5
22 13 7
8
1 9
1 1 10
2
4
10
8 1
1 8 2 1
14 11 1
1
3
8
12 2 6 7 3 4 3 4 3 4 1 4 1 2 8 1
2
1 2 3 1 1 1
2 1 2 2 1 2
2 2 2 2 2 7 2
2
1
4 1
3 3 1 5
7 2 4 7
7 3 1 7
10 2 1 14 3
4
6 1
III II III
III III II III III III III III III II III II + III III
III II II II III III
III III II III II III III III III
II III II + III
CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 CUL9 CUTA CUTC CUX1 CWC15 CWC22 CWC25 CWC27 CWF19L1 CWF19L2 CXADR CXCL16 CXCR4 CXXC1 CXXC4 CXXC5 CXorf38 CXorf40A CXorf40B CXorf56 CXorf57 CXorf69 CYB561 CYB561D2 CYB5A CYB5B CYB5D1 CYB5D2 CYB5R1 CYB5R2 CYB5R3 CYB5R4 CYB5RL CYBA CYBASC3 CYBRD1 CYC1 CYCS CYFIP1 CYFIP2 CYHR1 CYLD CYP11A1 CYP1B1
2
2
1 3 1
1 1
2
13
1
3 2 2 1 2 1 24
1
1
3
1
11
15
13
3
1 1 3 4
3 1
1 4 1
3 3 1
6 13 3
1
2 4 1
2
3
1
3 1 1 1
1 1 1
5 2 3 1 1 4 1
3
2 3
3 1
11
16
17
1 2
II III II II III II II II III II II II + III II III III III II III II III II II II III III III II II III III
III III III II III II III II II III
CYP26B1 CYP2R1 CYP2S1 CYP2U1 CYP51A1 CYR61 CYSTM1 CYTH1 CYTH2 CYTH3 D2HGDH DAAM1 DAB2 DAB2IP DAD1 DAG1 DAGLB DAK DALRD3 DANCR DAP DAP3 DAPK3 DARS DARS2 DAXX DAZAP1 DAZAP2 DBF4 DBF4B DBI DBN1 DBNDD1 DBNDD2 DBNL DBP DBR1 DBT DCAF10 DCAF11 DCAF12 DCAF13 DCAF15 DCAF16 DCAF17 DCAF4 DCAF5 DCAF6 DCAF7 DCAF8 DCAKD
1
2
9 2
3 1
1 5 7
2 2 1
2 3 4
2 9 4 1 5 3 9
2 1 22 2
5 4 2 35 2
6
1 5
1
3
1 2 1
3 3 1 3 2 1
1 2 3 2
1 6
1 11 8 1 46 5 2 1 8 1 7
5 7 2 2 3 1 2 12
4 1 3
5 1 2
2
3 3 1
2 7
1
4 1 6 3
10
2 1
9 4
II + III III
II + III
III III III III III II II + III III III II + III III III III II III III II
III II + III II II III III III III III III II III III II II II + III II
DCBLD1 DCBLD2 DCK DCLK2 DCLRE1A DCLRE1B DCLRE1C DCP1A DCP1B DCP2 DCPS DCTD DCTN1 DCTN2 DCTN3 DCTN4 DCTN5 DCTN6 DCTPP1 DCUN1D1 DCUN1D2 DCUN1D4 DCUN1D5 DCXR DDA1 DDAH1 DDAH2 DDB1 DDB2 DDHD1 DDHD2 DDIT3 DDIT4 DDOST DDR1 DDR2 DDRGK1 DDT DDTL DDX1 DDX10 DDX11 DDX17 DDX18 DDX19A DDX19B DDX20 DDX21 DDX23 DDX24 DDX27
4 1 1
3
3 7 2
1
4
8 2 1
1
2 3 1 1
3
1 1
3 6
5 12
1
1 2 2
1 4 4 2
2 4
1 1
5 2 5
1 1 5
1
1 6 1
1 2
4 2
2 1 5 4 9 1 1 1 1
1 3 10 6 6 3 1 2 1
1 1
9 2
4 5 2 2
2 5 2 2
5 19 4 1 4 6 13 8 4
III II III II III II III II III III III III II III II II + III III III III II + III III II + III II III
II II + III II + III III III III III III II II
III II III III II + III
DDX28 DDX31 DDX39A DDX3X DDX41 DDX42 DDX46 DDX47 DDX49 DDX5 DDX50 DDX51 DDX52 DDX54 DDX55 DDX56 DDX59 DDX6 DEAF1 DECR1 DECR2 DEDD DEDD2 DEF8 DEGS1 DEK DEM1 DENND1A DENND1B DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENR DEPDC1 DEPDC1B DEPDC5 DEPDC7 DERA DERL1 DERL2 DET1 DFFA DFFB DFNA5 DFNB31 DGAT1 DGAT2 DGCR14
1 5 3 1 1 1
2 1 10 4 1 1 1 1 1
3 4 12 3 2 1 3 9 1 3 2
1 1 1 1 4
1 1 1 13
3 2 2 25 2 1
2
6 2 3 11 3
10 8 4 13 5
1
5 1
2
1
3 3
4 3
2 1 12 4
4 1
3 1
2 1
2 3 3
2 1 1
1 4 1 5
3
2
8 1
1
1
8
II III III III II
II III II II III III III III III II III III III II II + III III II II + III
III II
II II II III III II + III II + III III II + III
DGCR2 DGCR6 DGCR6L DGCR8 DGKA DGKD DGKH DGKQ DGKZ DGUOK DHCR24 DHCR7 DHDDS DHODH DHPS DHRS1 DHRS11 DHRS13 DHRS2 DHRS3 DHRS4 DHRS4L2 DHRS7 DHRS7B DHTKD1 DHX15 DHX16 DHX29 DHX30 DHX32 DHX33 DHX34 DHX35 DHX36 DHX37 DHX38 DHX40 DHX57 DHX8 DHX9 DIABLO DIAPH1 DIAPH2 DIAPH3 DICER1 DICER1-AS1 DIDO1 DIEXF DIMT1 DIP2A DIP2B
11
11
18 2 4
2
2 14 11
4
1 1
2 3 2
4 1 5 1 23 11 2 1
3 1 1 1 1 1 2 1
4 2 5
5 2 1 9 1 29 16 8 1
3 6 1 1 1 2 1 8 2 10 8 2 1
1
2
1 2 2 9 1
2 2 14
2
2
8
9
3 1 2 2 2 2 13 2 5 3 24 3
1 1
3
4 4
III II III II + III II + III II II III III III III II + III II III III III II + III II II + III III II III
II
III III II III III II + III III II II III III III III
DIRAS1 DIRC2 DIS3 DIS3L DIS3L2 DISP1 DIXDC1 DKC1 DKK1 DLAT DLD DLEU1 DLG1 DLG3 DLG4 DLG5 DLGAP4 DLGAP5 DLL3 DLST DLX1 DLX2 DLX4 DLX6 DMAP1 DMD DMPK DMRTA1 DMTF1 DMWD DMXL1 DMXL2 DNA2 DNAAF2 DNAAF3 DNAH14 DNAJA1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB12 DNAJB14 DNAJB2 DNAJB4 DNAJB5 DNAJB6 DNAJB9 DNAJC1 DNAJC10 DNAJC11
1
1
6 2 2 1 1 7 5 3 3 2 3 1
1 1 3 3
3 1 7 9
7 3 2
3 9 5 10 3
1
1
2 2 2
4 3 3 2 1
1
3 2
1 2 1 1
1
2 1
2 1
2
2 1 1 4 12 2
1 4 2 4 14
1
2
4 1 1
3 1 2
1
2
4 1
1 1
1 2
2
4
5
III II + III III III III III III II III III II II + III III II II + III II II III III III III II III III III III III III III III II
II + III III
III III II + III II II II + III
DNAJC12 DNAJC13 DNAJC14 DNAJC15 DNAJC16 DNAJC17 DNAJC18 DNAJC19 DNAJC2 DNAJC21 DNAJC22 DNAJC24 DNAJC25 DNAJC3 DNAJC30 DNAJC4 DNAJC5 DNAJC6 DNAJC7 DNAJC8 DNAJC9 DNAL1 DNAL4 DNASE1L1 DNASE2 DNER DNLZ DNM1L DNM2 DNMBP DNMT1 DNMT3A DNMT3B DNPEP DNTTIP1 DNTTIP2 DOCK1 DOCK10 DOCK4 DOCK5 DOCK6 DOCK7 DOCK9 DOHH DOK1 DOK4 DOLK DOLPP1 DOM3Z DONSON DOPEY1
2
2
5
2
3 1
2
3 1
3 1
2 5
4 1 1 1
2 1 1 2
1 4 1 6 4 7 9 4 1 3 3 1
1 3
4
1
1 1 1 3
1
3 5
3 4 4 4 1
1
1
4
2
5
11
1 1 2 1 3
2 7 3 2 1
2 2 4 2 10 2 5 2
II II III III III II II III III II III III II II
III II III II III III III III II III II + III II II III II + III III III III III III III III III III III II + III
DOT1L DPAGT1 DPCD DPF1 DPF2 DPH1 DPH2 DPH3 DPH5 DPM1 DPM2 DPM3 DPP3 DPP7 DPP8 DPP9 DPY19L1 DPY19L4 DPY30 DPYSL2 DPYSL5 DR1 DRAM1 DRAM2 DRAP1 DRG1 DRG2 DROSHA DSCC1 DSCR3 DSE DSEL DSG2 DSN1 DSP DSTN DSTNP2 DSTYK DTD1 DTL DTNB DTNBP1 DTWD1 DTWD2 DTX3L DTYMK DUS1L DUS2L DUS3L DUS4L DUSP1
1 1
4 5
10 5 1
1 2 2
5 4 1
1 6 5 1
1 1
6
4
3
6 1 2 3
2
1 1
4 3
4 4 1
1 1 1 4
1 1
7 1 6 2 2
1 4
1 1 7
5
2 4 3 4 1 2
2 17 8 5 5 6
1
1
2 1 4 1 1 1 1 1
3
1 2
1
1
1 1 2 3
2
9
III II II + III II III III II + III II III III II III III III II III II
III II II II III III II + III III II + III II + III III III II II II + III II III II + III III III III
III II
DUSP10 DUSP11 DUSP12 DUSP14 DUSP16 DUSP2 DUSP22 DUSP23 DUSP3 DUSP4 DUSP7 DUSP9 DUT DVL1 DVL2 DVL3 DYM DYNC1H1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2H1 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 DYRK1A DYRK1B DYRK2 DYRK3 DYRK4 DZIP1L DZIP3 E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 E2F7 E2F8 E4F1 EAF1 EAF2 EAPP EARS2 EBAG9 EBNA1BP2 EBP
2
1 3
1 1 6 1
4 11 1
6 28 3
2 8 4
3 2
4 11 2
1 1
1 1 1
1 5 1 1 1 5
5
3
1 1
1 1
1
2 1 1
6 2 2
5 3 2
2
5 1 3 1 1
21 4 8 4
3 2 1 1 1 7 2
3 1
2 3 1 14 4
8 7 16 8
3 2
2 2 3 1 6
3
6
3
1 2
1 10 1 5
II III II III III II II III III III III III II + III II II II + III III II II III II III II II III III III III II III III III II III
III II III II + III II + III
EBPL ECD ECE1 ECE2 ECH1 ECHDC1 ECHDC3 ECHS1 ECI1 ECI2 ECSIT ECT2 EDC3 EDC4 EDEM1 EDEM2 EDEM3 EDF1 EDN1 EDNRA EEA1 EED EEF1A2 EEF1B2 EEF1D EEF1E1 EEF1G EEF2 EEF2K EEFSEC EFCAB11 EFCAB2 EFCAB7 EFEMP1 EFHA1 EFHC1 EFHD1 EFHD2 EFNA1 EFNA3 EFNA4 EFNA5 EFNB1 EFR3A EFR3B EFTUD1 EFTUD2 EGFL7 EGFR EGLN1 EGLN3
1
2
2
13
23
26 2
1
1 1
2 1
1
1
1 4 1
3
6 2 2 3 1 1 3 7 1 1 4
1 2 1 1 2 1 1 2 1 3 10
3 3 2 2 1 1 1 3 1 7 2 3 9
1
4
7
15 4 8 14 1 2
6
2 3 2
1 1 6 2 1 4 3 5
2
2 3
1 3 5
5 1
16 1
22 4
3
1 1 4
III II II II + III III III
II II II III II II III
II + III III III III III II + III III III III II II II II III III II II III III II II III II II II III III III III
EHBP1 EHBP1L1 EHD1 EHD2 EHD4 EHMT1 EHMT2 EI24 EID1 EID2 EID2B EIF1 EIF1AD EIF1AX EIF1B EIF2A EIF2AK1 EIF2AK2 EIF2AK3 EIF2AK4 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2C1 EIF2C2 EIF2C3 EIF2D EIF2S1 EIF2S2 EIF2S3 EIF3A EIF3B EIF3D EIF3E EIF3F EIF3G EIF3H EIF3I EIF3J EIF3K EIF3L EIF3M EIF4A2 EIF4A3 EIF4B EIF4E EIF4E2 EIF4E3 EIF4EBP1
2
6 1 1
1 3 1 2 7 3 1
2
3 1 2
4 4 2
1 3
2 2 1
1
1 1
3 1 4 1
1 1
1 1 1
2 1 2 2 4 4 2 1
2 1
1 4 1 1 1 1
2 1 2
2 1 6
10 12 8 6 4 2 5 1 4 8 3 3 3 7 1 2 2 4 1
2 5 1 1 2 2 13 8 2 1
2 3 1 6 1 2 2 2 1 14 2
1 1
II III II II III II II II II II II II
II + III II II
III III
III III II II II + III
II III II II + III III III III II + III II II II III III II III II
EIF4EBP2 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EIF4H EIF5 EIF5A EIF5B EIF6 ELAC1 ELAC2 ELAVL1 ELF1 ELF2 ELF3 ELF4 ELFN2 ELK1 ELK3 ELK4 ELL ELL2 ELL3 ELMO2 ELMOD1 ELMOD2 ELMOD3 ELOF1 ELOVL1 ELOVL5 ELOVL6 ELOVL7 ELP2 ELP3 ELP4 EMD EME1 EMG1 EML1 EML2 EML3 EML4 EMP2 EMP3 ENAH ENDOG ENDOV ENG ENGASE ENO1
1 8 4
3 1 8 8
1 3 2 3 1
7 8 5 4 3
1 1
1 1 3 1 4 5 2 1
1 1 1
3
1
5 1 19 8 6 6 4 6 4 2 1 2 5 2 3 6 11 7 2
7
6 4 7
2
2
1 1
4 4 1
7 6 1
10 6 5
1
1 2
3
1 1
1 3 2
4 5 1
3 3 4 2
5 3 2 5
1 5 4 4 12
5
4
8
6
10 2 14
III III III III
III III II III II + III II II II II III III III III
III II + III
II + III II + III II III III II + III II II + III II + III II + III
III III III II III
II + III
ENO2 ENO3 ENOPH1 ENOSF1 ENOX1 ENOX2 ENPP1 ENSA ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENY2 EP300 EP400 EPAS1 EPB41 EPB41L1 EPB41L2 EPB41L3 EPB41L4A EPB41L4A-AS1 EPB41L4B EPB41L5 EPB49 EPC1 EPC2 EPDR1 EPG5 EPHA2 EPHB2 EPHB4 EPHX1 EPHX2 EPM2A EPM2AIP1 EPN1 EPN2 EPOR EPPK1 EPRS EPS15 EPS15L1 EPS8 EPS8L1 EPS8L2 EPT1 ERAL1 ERAP1 ERBB2 ERBB2IP
1
1 2
1 2
2 8
2 1
7 2
8
8 1 5 1 3
11 2 9 2 6
18 1 17 6 5 1
1
2 1 1
2 2
10 2 3
9 1 5
1 2 1 3 10 1
2 4 3 3 14
1
1 2 1
5
3
6
1 2 7 4 3 1 18 5 8
1 7 7 7 6 16 2 1 2
9 4 6 1 8
II + III III III II + III
II + III II + III II II III II III
III III III
III II III II + III III III III III III II III II II II + III III III III
II + III II + III III
II III
ERC1 ERCC1 ERCC2 ERCC3 ERCC4 ERCC6 ERCC6L ERCC6L2 ERCC8 ERF ERGIC1 ERGIC2 ERGIC3 ERH ERI1 ERI2 ERI3 ERICH1 ERLEC1 ERLIN1 ERLIN2 ERMP1 ERO1L ERO1LB ERP29 ERP44 ERRFI1 ESAM ESCO1 ESCO2 ESD ESF1 ESPL1 ESRRA ESYT1 ESYT2 ETAA1 ETF1 ETFA ETFB ETFDH ETHE1 ETNK1 ETS1 ETS2 ETV3 ETV4 ETV5 ETV6 EVC EVI5
3
12
1
2
1 1 2 2
2 2 8 3 1 2 1
1
1 1 3 4
2 1
4 1 3 2
28 1 2 11 3 2 3 8 12 7 1 5 2 1 1 1 1 5 2 3 3 1 5 1 6 2 2 1
1
1
2
3 1
5 5
2
4 1
4 3 2 9 4 1 1 3 1
1
1 1 2
2 1
3 4
5 9
2 2
3 5 9 1
III III III III
II III II
III III II III III III III III II + III II + III II + III III II + III III III II III III II + III III III II + III II III III III II + III III III III
EVI5L EVL EVPL EWSR1 EXD2 EXO1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC6B EXOC7 EXOC8 EXOG EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 EXT1 EXT2 EXTL2 EXTL3 EYA3 EYA4 EZH1 EZH2 EZR F11R F12 F2R F3 F8 FABP3 FADD FADS1 FADS2 FADS3 FAF1 FAF2 FAH FAHD1 FAHD2A FAHD2B
1 1 3 2 1 2 1 1 2
3
3
2 1 2 1 2 1 1 1 5
1
1 2
3 1
10 3 1 2
1 3
1
11 1 2
2
9
3 1
1
2 1
11 5 4 23 3 7 1 1 2 2
1
5
8
7 1
6 2 1 20 2 4
1 6 2
5 7
1
1 1 7
11 6 4 1 1 14
1
2
III II III III III II + III II II + III II + III II + III II + III
II + III II III
III II + III II + III III II II III III II II II + III II II II II + III
III III II + III
FAIM FAM100A FAM100B FAM101B FAM102A FAM102B FAM103A1 FAM104A FAM104B FAM105A FAM105B FAM107B FAM108B1 FAM108C1 FAM109A FAM109B FAM110A FAM110B FAM110C FAM111B FAM114A1 FAM114A2 FAM115A FAM116A FAM117A FAM117B FAM118A FAM118B FAM120A FAM120B FAM120C FAM122A FAM122B FAM125A FAM126A FAM127A FAM127B FAM127C FAM129A FAM129B FAM131A FAM134A FAM134B FAM134C FAM135A FAM136A FAM13A FAM149B1 FAM160A1 FAM160A2 FAM160B1
2
7 5 3 5 2 1 8 1 1 8 1 10 6 4 5 2 5 3 1 3
1
2 1
2 1
1 2
7 4
3
1 2 2 1 3
13 3 3 3 5
1 6 3 1 8 1 4 3 1 2 1 1
1 7 7 10 3 22 2 6 3 6 2 2 2
1 3 1
3 10 5
3
4 4 1
1 1 1 1 1 4
1 2 1
1
2 1 1 1 11 1 2 1
1
5 1 1 1 1 1 2 1
1
II III III III III III III II III II + III II III III III II III III
III III II + III III III III II + III II + III II + III II + III III III II + III III III II + III III III
III II
FAM160B2 FAM161A FAM162A FAM165B FAM168A FAM168B FAM169A FAM172A FAM173A FAM173B FAM174A FAM175A FAM175B FAM176C FAM177A1 FAM178A FAM179A FAM188A FAM189A2 FAM189B FAM18B1 FAM190B FAM192A FAM193A FAM193B FAM195A FAM195B FAM199X FAM200A FAM204A FAM206A FAM207A FAM208A FAM208B FAM20B FAM20C FAM210A FAM210B FAM213A FAM213B FAM214A FAM214B FAM216A FAM217B FAM219A FAM219B FAM21C FAM220A FAM24B FAM32A FAM35A
2
2
3 1
1 3
2 8 3 1 1
1
1
1
1
2 1
3 1 2
6 4 2 3 1 1
1
1 5
4 1 1 1 2
3
1 2 8 4 3
1 2 12 4 4
4 2 4 1 3
1 5 1 3 6 22 12 12 2 1
1
1 1 1
1 3 1
1
4
7 3
1 3
1 1
3 1 6 2
III III
II II + III II + III II + III III III III
II II III II + III III
III II III III II III III III II + III II III II + III II + III II II II III III II III III III III
FAM3A FAM3C FAM40A FAM40B FAM43A FAM46A FAM46B FAM46C FAM48A FAM49B FAM50A FAM50B FAM53A FAM53B FAM53C FAM54A FAM54B FAM57A FAM58A FAM60A FAM63A FAM63B FAM64A FAM65A FAM69A FAM72B FAM72D FAM73A FAM73B FAM76A FAM76B FAM78A FAM81A FAM82A2 FAM82B FAM83D FAM83G FAM83H FAM89A FAM89B FAM8A1 FAM91A1 FAM92A1 FAM96A FAM96B FAM98A FAM98B FAM98C FAN1 FANCA FANCB
1
1 2 2 1
2 3 3 1 3 1
1 4
4 10
2
4
2 1 2 6 7 7 3 5 5
14 16 2 3 4 4 2 2 1 5 2 7 7 1 1 3
3
3
1
4 3 1
1
1 2
1
1
6 3 10
4 5 11
3 1
2 1
2
1 2
1 2
1 1
4 2 3
7 1 1 8 9 24 2 6 1 1
II II III III
II + III II III II + III III III III II III
II + III III III III II II II II II + III III II + III II II III II + III III
III III
FANCC FANCD2 FANCE FANCG FANCI FANCL FANCM FAR1 FARP1 FARP2 FARS2 FARSA FARSB FAS FASN FASTK FASTKD1 FASTKD2 FASTKD3 FAT1 FAU FBF1 FBL FBLIM1 FBLN1 FBLN2 FBLN5 FBN2 FBRS FBRSL1 FBXL12 FBXL14 FBXL15 FBXL16 FBXL17 FBXL18 FBXL19 FBXL2 FBXL20 FBXL3 FBXL4 FBXL5 FBXL6 FBXO10 FBXO11 FBXO17 FBXO18 FBXO2 FBXO21 FBXO22 FBXO28
1 1
1 1 1
1 1 1
2 1
7 4 2 1 1 3 2 1 3 1 2
1
2 3 1
14
7
1 5 1
12
1
1
3 1 2 1 1 3
1
4
1
5
6
2 3 8 16 1 23
1 6 2
1 11 5
5 6
1 1
1 1
1 2
13 2
3 18 1
2 2 29 10 1 1 1 6 2 3 3 3 1 2
3
7
II + III II + III
II II + III III II + III II + III III III II + III III II III III III III III III II III III III III II + III II + III II + III III II II III III II + III
III III III
FBXO3 FBXO30 FBXO31 FBXO33 FBXO34 FBXO38 FBXO4 FBXO41 FBXO42 FBXO44 FBXO45 FBXO46 FBXO5 FBXO7 FBXO8 FBXO9 FBXW11 FBXW2 FBXW4 FBXW5 FBXW7 FBXW8 FBXW9 FCF1 FCHO1 FCHO2 FCHSD1 FCHSD2 FDFT1 FDPS FDX1 FDX1L FDXACB1 FDXR FECH FEM1A FEM1B FEM1C FEN1 FER FERMT1 FERMT2 FEZ2 FGD1 FGD4 FGD5-AS1 FGF2 FGFBP1 FGFR1 FGFR1OP FGFR1OP2
4
2 3
2
4
1 4 9 2 10
2 4
2 5
4 9
1 3
1 2 1
3 10 5 5
1 15
4 16
6 1 2
13 2 7
8 5
2 1
2
5 4 5 1 1 1
2
2 1 1 1 1 1
3
11 11 2 1
13 11 10 8
1 1
3 3
1 2
1 4
5
11
2
1 1 1
II III III III III III III III III III II + III II + III III III II + III II II + III II II III III III II III III III II II + III II II + III III III
III II II II III II
III III III
FGFR3 FGFR4 FGFRL1 FH FHDC1 FHL1 FHL2 FHL3 FHOD1 FIBCD1 FIBP FIG4 FIGN FIGNL1 FIP1L1 FIS1 FITM2 FIZ1 FJX1 FKBP10 FKBP14 FKBP15 FKBP1A FKBP2 FKBP3 FKBP4 FKBP5 FKBP7 FKBP8 FKBP9 FKBPL FKTN FLAD1 FLCN FLII FLJ27352 FLJ31306 FLJ35776 FLJ37453 FLJ39051 FLJ46906 FLNA FLNB FLOT1 FLOT2 FLVCR1 FLVCR1-AS1 FLVCR2 FLYWCH1 FLYWCH2 FMNL1
1
2 1 6
3 7 1
2 1 1 2
1 4 2 5 1
1 7
7 14
1
4 5 7 12 1 2
1 7 7 14 15 2 8
4
1 6
3
1 3
3 6 3
2 5 7
5 2 1 1
8 7 1 1 3
1 3 8 6
2 1
2
15 5 2 3
17 2 3 1 1
22 2 5 4 4 1 1
1 1
1
III III II III III III III
II + III III III III II + III III II + III II + III II + III II + III II + III II + III III II + III II + III II + III II II + III III III II II III III II + III III III II + III II + III II III
FMNL2 FMNL3 FMR1 FN1 FN3K FN3KRP FNBP1 FNBP1L FNBP4 FNDC3A FNDC3B FNIP1 FNIP2 FNTA FOCAD FOLR1 FOPNL FOS FOSL1 FOSL2 FOXC1 FOXC2 FOXD1 FOXF1 FOXF2 FOXJ2 FOXJ3 FOXK1 FOXK2 FOXL2 FOXM1 FOXN2 FOXO1 FOXO4 FOXP1 FOXP4 FOXQ1 FOXRED1 FOXRED2 FPGS FRA10AC1 FRAT2 FRG1 FRG1B FRMD6 FRS2 FRY FRYL FSCN1 FSD1 FST
1 1 2
2 1
5 4
1 4 1 1
4 6 4 7 1 2
1
1
2 2 3 2
2 1 2 7 3 2 1 1 3
17 18 4 8 2
1 1 10 9 2 1 2 8 2 20 22 7 12 1 3
3
1 2 3 11 16 9 8 7 14 6 4 41 35 14 22 3 8 2 5 2 1 6 16 2
1 3
7 7
1
3
6
3
3
1 9
1 3
1 10
6 8
1
II II II II III II + III III II II II II III III III II II
III III II II II III II + III II + III II + III II + III II III II III II II III III III III III
FSTL1 FSTL3 FTH1 FTL FTO FTSJ1 FTSJ2 FTSJ3 FTSJD1 FTSJD2 FUBP1 FUBP3 FUCA1 FUCA2 FUK FUNDC1 FUNDC2 FURIN FUS FUT10 FUT11 FUT8 FXC1 FXN FXR1 FXR2 FXYD5 FYCO1 FYN FYTTD1 FZD2 FZD6 FZD8 FZD9 FZR1 G2E3 G3BP1 G3BP2 G6PC3 G6PD GAA GAB1 GABARAP GABARAPL1 GABARAPL2 GABPA GABPB1 GABPB2 GABRA3 GABRE GABRQ
10 2 1 4
2
11 3 6 3 4 1 4
1 1 1
4 2 3 3
2
2
5 3
8 1 2
1 1 2 2 10 1 3 2 2
3
1 1
1 1 1 3 5 3 1 1 12 2 3 3 5 1 7 2 2 3 1 1 1 1 1
1
11 11 8 12 10 3 8 1 5 1 3 4 2 1 1 3 12 2 1 1 1 2 3 1 4 1 3 4 2 22 6 11 4 11 1 5 9 4 3 2 1 4 1 1 1 1
5 1
III III III III III III III III II II + III II + III III III II II III II II + III II II III III II II II II II III II II III III III II + III III III III
GAD1 GADD45A GADD45B GADD45GIP1 GAK GAL GALE GALK1 GALK2 GALM GALNS GALNT1 GALNT10 GALNT11 GALNT2 GALNT7 GALT GAMT GAN GANAB GANC GAPDH GAPVD1 GAR1 GARS GART GAS1 GAS2L1 GAS2L3 GAS5 GAS6 GAS8 GATA2 GATA6 GATAD1 GATAD2A GATAD2B GATC GATSL1 GBA GBA2 GBAP1 GBAS GBE1 GBF1 GCAT GCC1 GCC2 GCDH GCFC1 GCFC2
2 2
1 3
1
4 3 1
1 1 2
5
1 1 2 16
1
6
9
10
7
9
8 1
7
1 1 13 3 2
2
1 10
2 13
3 17
1 4 1
4 6 9 2
4 22 12 6
2
2 3 3
3 8 4 1
1
4
6
9
1 1
1 1
1
20 3 4
4 1 11 2 4 1 19 1
2 11 2 7 5 1 3 2 21 13 9 1
1
1
III III III II III II III II II II + III II II III III III III III II + III II + III
II III
II + III
III II + III III III III III III III III III III III II III III III
GCH1 GCHFR GCLC GCLM GCN1L1 GCNT2 GCSH GDA GDAP1 GDAP2 GDE1 GDF11 GDF15 GDI1 GDI2 GDPD1 GDPD5 GEM GEMIN2 GEMIN4 GEMIN5 GEMIN6 GEMIN7 GEMIN8 GEN1 GET4 GFER GFM1 GFM2 GFOD1 GFOD2 GFPT1 GGA1 GGA2 GGA3 GGCT GGCX GGH GGNBP2 GGPS1 GGT1 GGT7 GHDC GHITM GIGYF1 GIGYF2 GIN1 GINS1 GINS2 GINS3 GINS4
3
1 3 2
1 1 5 4
4
4
10
1 3 2 5 2
1 3 2 3 2 1
2 4 8 5 6 6
1
1
10 1
10 3
21 2 1 1
1
2 5
4 4 4 1
1
6 2
2 5
5 4 17
1
1
1 3
2
1
1
1
3
1 1
7 11 1 1 2 7 1
III III II + III III II
II II + III III II III II III III III III III III II II II + III
III III III
III III II III III III III III III II + III II + III
GIPC1 GIT1 GIT2 GJC1 GK5 GKAP1 GLA GLB1 GLB1L GLB1L2 GLCCI1 GLCE GLE1 GLG1 GLI3 GLIPR2 GLIS2 GLMN GLO1 GLOD4 GLP2R GLRX GLRX2 GLRX3 GLRX5 GLS GLT25D1 GLT8D1 GLTP GLTPD1 GLTSCR2 GLUD1 GLUL GLYCTK GLYR1 GM2A GMCL1 GMDS GMEB1 GMEB2 GMFB GMIP GMNN GMPPA GMPPB GMPR2 GMPS GNA11 GNA12 GNA13 GNAI1
2 1 1 7
5 1 12
1
1 3
2 4
1 3 2
1 2
2
4
2 11 2
1 6 5 2 12 7
1
2
13
2 1 2
1
1 1 17 2
1 4 11 1
2 1
7
1 12 1
1 1
1 3 1 1
1 2
1
1
5 4 1 3 9 3 2 1
2
5
1 1 12 2
1 16 6
1
9 2
III
II III II II II III III II III III III III II III III II III II III III III III III III II II + III III II III II II + III II II II II
III
GNAI2 GNAI3 GNAL GNAQ GNAS GNAS-AS1 GNB1 GNB2 GNB2L1 GNB4 GNB5 GNE GNG11 GNG12 GNG5 GNL1 GNL2 GNL3 GNL3L GNPAT GNPDA1 GNPDA2 GNPNAT1 GNPTAB GNPTG GNS GOLGA1 GOLGA2 GOLGA3 GOLGA4 GOLGA5 GOLGA7 GOLGB1 GOLIM4 GOLM1 GOLPH3 GOLPH3L GOLT1B GON4L GOPC GORAB GORASP1 GORASP2 GOSR1 GOSR2 GOT1 GOT2 GPAA1 GPAM GPANK1 GPATCH1
2
9
4 3 3 1 17
3 1 1
11 2 2
10 4 6
1
3 3
1
1
4 1
1
4 1 1
2 2 8 1
2
3
2
2 1
1 5 3 1 2
1 2
1 1 3
1 1
2
3
1 2 3 1 1 8 1
1 2 2 5 1
3
1
3 16 1 1 4 3 4 1 2 7 1 3 3 5 1 9 1 1 10 1 10 5 5 4 3 16 2 1 2
II + III III III II II + III III II III II + III III II III III III III II II II + III III II + III II + III II + III II II + III
II III III II II III II III
III III
III
GPATCH2 GPATCH3 GPATCH4 GPATCH8 GPBP1 GPBP1L1 GPC1 GPD1L GPD2 GPER GPHN GPI GPKOW GPN1 GPN2 GPN3 GPNMB GPR107 GPR108 GPR124 GPR125 GPR126 GPR137 GPR157 GPR161 GPR176 GPR180 GPR37 GPR56 GPR89A GPRC5A GPRC5C GPRIN1 GPS1 GPS2 GPSM1 GPSM2 GPT2 GPX1 GPX4 GPX8 GRAMD1A GRAMD1B GRAMD3 GRAMD4 GRB10 GRB2 GRB7 GREB1L GRHL1 GRHPR
1
2
5 1
8 4
1 1
1
3 1 3
5
1
1
3 2 5
6
1 7 1 2 4 1
4 3 1 21 5 1 4 1 4 13 1 7 1 1
3 9 1 2 7 1
3 1
3 4
1 18
3 23
11
21
1 14 3 1 9 30 1 25
1
1 1
2 2 1
2 3 1 2
1
1 4 4 1
2 5 5 2 4
3 2
1 1 7 4
1
1 1
II III III II II II + III II III II + III II + III III II III II III III III II III III III II III III III II II III II + III III III III III III II III III III II II II + III III III II III
GRINA GRIPAP1 GRK5 GRK6 GRN GRPEL1 GRPEL2 GRSF1 GRTP1 GRWD1 GSG2 GSK3A GSK3B GSN GSPT1 GSR GSS GSTA4 GSTCD GSTK1 GSTM3 GSTM4 GSTO1 GSTP1 GSTT1 GSTT2 GSTZ1 GTDC1 GTF2A1 GTF2A2 GTF2B GTF2E1 GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 GTF2I GTF2IRD1 GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 GTPBP1 GTPBP10
5
8
1 1 3 1
5 1 2 3
2 2
5 5 2 3
1 1
6 1 2
2
2
7 1 4 4 4 4 6 3 9 12 1 7 1 10 3 1
2
6 1 4
1
3
3
1 1
1 2
2 3
2
1
2 1 6 1 3 1 1 1 2
1
1
1 4 1
3 2
3 7
5
9 2
1
4 1
15 7 1 5 5
II + III III III II + III III III II III III III III II III III III III III II III II II + III III II III II + III III III III III III III III II + III III II + III III III III III III III III III III III
GTPBP2 GTPBP3 GTPBP4 GTPBP5 GTPBP6 GTPBP8 GTSE1 GUF1 GUK1 GULP1 GUSB GXYLT1 GXYLT2 GYG1 GYG2 GYS1 GZF1 H19 H1F0 H1FX H2AFJ H2AFV H2AFX H2AFY H2AFZ H3F3B H6PD HABP4 HACE1 HACL1 HADH HADHA HADHB HAGH HAGHL HARBI1 HARS HARS2 HAT1 HAUS1 HAUS2 HAUS3 HAUS4 HAUS5 HAUS6 HAUS7 HAUS8 HAX1 HBP1 HBS1L HBXIP
1
4
2
6 1 1 4
1 1 1
1 1
1
15 2 11 1 7 1 1 1 3 4 1 5
1 3 1
5
2 7
2 4 3 2 1 4
1 1
2 2 1
1
1
1
1
3 1 4 1 1 11 3 1 2 14
4
1 1 2
1 1
2
2
2 4 1 2 3
3 1
2
III II III III III III III III III III III II III III III II III III III II + III II II + III II
II + III III III III II + III III II + III III II III
II
HCCS HCFC1 HCFC1R1 HCFC2 HCN2 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDDC2 HDDC3 HDGF HDGFRP2 HDGFRP3 HDHD1 HDHD2 HDHD3 HDLBP HEATR1 HEATR2 HEATR3 HEATR5A HEATR5B HEATR6 HEATR7A HEBP1 HEBP2 HECA HECTD1 HECTD3 HECW1 HEG1 HELB HELLS HELQ HELZ HEMK1 HENMT1 HERC1 HERC2 HERC3 HERC4 HERC5 HERPUD1 HERPUD2
1 8 2
12
1
2 24 3 1 5
1
1
3
7
1 1 13
1 4 1 1 8 1 5 2 13
1 2 4 1 5
2 4 2 2
5 12 4 16
1
1
1 1
1
2 2
5 1
2 11
1 16 1 1 3 4 3
8 1 1
5
1 2 1 1 1
5
3 1
III III III II III II
III II III III II II III II III III II
II III III II III II + III II + III III II + III II + III II + III II + III
II + III
II II + III II + III II + III
II + III
HES6 HES7 HEXA HEXB HEXDC HEXIM1 HEXIM2 HEY1 HFE HGS HGSNAT HHAT HHEX HHLA3 HIAT1 HIATL1 HIBADH HIBCH HIF1A HIF1AN HIGD1A HIGD2A HILPDA HINFP HINT1 HINT2 HINT3 HIP1 HIP1R HIPK1 HIPK3 HIRA HIRIP3 HIST1H1C HIST1H2AC HIST1H2AG HIST1H2AI HIST1H2AM HIST1H2BC HIST1H2BD HIST1H2BF HIST1H2BJ HIST1H2BK HIST1H2BN HIST1H2BO HIST1H3D HIST1H3H HIST1H4H HIST1H4I HIST2H2AC HIST2H2BE
1 2 3
2
2
2
4
8
1
1 1
2
1 3
1 4
3 3
2
3
1
1
1 2
3
1 1
3 3 1
6 1 5 2 1
1 1 1 1
3 1 2 3
3 1 2 1 1
1 1
1
1 1 1 1 2 1
1
3
1
2 1
4 9 2 1 3 1 1 4
2 1 1 11 12 6
4 3 1 1
2 2 2 4 2 3 3
1
II + III II + III II III III III III II + III III II III II II III III III II II III III III II III III III III III II II III II III II + III II III II III III III II II III
HIST3H2A HIVEP1 HIVEP2 HJURP HK1 HK2 HLA-A HLA-B HLA-C HLA-E HLCS HLTF HM13 HMBOX1 HMBS HMG20A HMG20B HMGA1 HMGB2 HMGB3 HMGCL HMGCR HMGCS1 HMGN1 HMGN2 HMGN3 HMGN4 HMGXB3 HMGXB4 HMHA1 HMMR HMOX1 HMOX2 HN1 HN1L HNRNPA0 HNRNPA1L2 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPF HNRNPH1 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR HNRNPU HNRNPUL1 HNRNPUL2
1 5 2
7 2 3 1
17 6 4 2
2
1
2
2 2
5
18
1 4 2 18 1
1 1 1
1 5
1 1
1 2 5
2 2
4 3 7 3
1 1 3 1
5
1 3 3 1 1 12 2
1
1
4
1 11 1 4 3 1
2 1
1 2
1
5 3 1 3 7 2 1
7 8
3 4 1
1 3 1 6 14 5 3 6 3 4 1 4 6 2 8 6 2
III III III III III III III
II III III II II + III II + III III
II III III II + III III III
II + III II + III III II III II + III III III II + III III III III III III
HNRPDL HNRPLL HOGA1 HOMER1 HOMER2 HOMER3 HOMEZ HOOK3 HORMAD1 HOTAIR HOTAIRM1 HOXA10 HOXA11 HOXA11-AS HOXA13 HOXA4 HOXB13 HOXB6 HOXB7 HOXB9 HOXC10 HOXC11 HOXC13 HOXC9 HOXD11 HOXD8 HOXD9 HP1BP3 HPCAL1 HPD HPDL HPRT1 HPS1 HPS3 HPS4 HPS5 HPS6 HPSE HR HRAS HRCT1 HRSP12 HS1BP3 HS2ST1 HS6ST2 HSBP1 HSBP1L1 HSCB HSD17B1 HSD17B10 HSD17B11
1
2 1
1 2 1
1 4
1 1 2 2 1 3 4 9 1
1
1 3 1
3 10 2 4 6 7 5 2 1 3 3 3 3
2
2
5
1 4
1 4
1 2 5 3 10
5
5
1
2
7 1 4
2
1 1 1
2 2 2 4
1
4
1 2 2
3 4 3
1
2 1 1
III III III III III II + III III III III III II II II II + III II II + III III III II II II II III III II III II II III III III II II III II II + III II + III II III II + III
II + III III II + III II + III III
HSD17B12 HSD17B4 HSD17B7 HSD17B8 HSD3B7 HSDL1 HSDL2 HSF1 HSF2 HSF2BP HSP90AA1 HSP90AB1 HSP90B1 HSPA12A HSPA13 HSPA14 HSPA1B HSPA4 HSPA4L HSPA5 HSPA8 HSPA9 HSPB1 HSPB11 HSPB7 HSPB8 HSPBAP1 HSPBP1 HSPD1 HSPH1 HTATIP2 HTATSF1 HTRA1 HTRA2 HTRA3 HTT HUS1 HUWE1 HYAL1 HYAL2 HYOU1 IAH1 IARS IARS2 IBTK ICAM1 ICAM3 ICAM5 ICMT ICOSLG ICT1
2 1
1
2
2
8 2
4 4 5
9 5 9 3 6 5 2 3
13 6 5 3 5 10 12 3 1 9 12 6 1
1 2 11
3 7 4 1
14 7 6 2
1
1
1 1
2 3 3 1
1 2 1 3 2 2 2 1
1 1 1 6 4 4 2
4 2 1 12 4 3 12
1 5 2 3 16 7 5 8
4
8 1
5
10
11
11
5 3
12 7
16 15 1
III II III III III III III III II II + III II III II + III II + III III III II III III III II II II
III III II III III III III III III III III III III III III II II + III II
II II II III
ID1 ID2 ID3 IDE IDH1 IDH2 IDH3A IDH3B IDH3G IDI1 IDS IER2 IER3 IER3IP1 IER5 IER5L IFI27L1 IFI27L2 IFI30 IFI35 IFI6 IFITM1 IFITM2 IFITM3 IFNAR1 IFNAR2 IFNGR1 IFNGR2 IFRD1 IFRD2 IFT122 IFT140 IFT172 IFT20 IFT27 IFT43 IFT46 IFT52 IFT57 IFT80 IFT81 IFT88 IGBP1 IGF1R IGF2BP1 IGF2BP2 IGF2BP3 IGF2R IGFBP3 IGFBP4 IGFBP6
4 2
1
3 2 1
1
1
3 8 13
3 9
1 8 11 1 3 16
1
2
1
1 1 2
1 1 4 3 1
1 11 6
1 3 1
1 2
3
4
8 20
2 2 7
1
2 15 4
1 2 21 9
6 2 3
1 4 3 4
3 3 29 13 2 1 10 5 10
II III III III III II + III III II
III
II + III II + III III III II + III II + III III II II III III III III II II + III II III III III II + III III III II II
III III II + III III III III
IGFBP7 IGFLR1 IGHMBP2 IGSF8 IK IKBIP IKBKAP IKBKB IKBKE IKBKG IKZF5 IL10RB IL11RA IL13RA1 IL15RA IL17RA IL17RB IL17RC IL18 IL27RA IL6R IL6ST IL7R ILF2 ILF3 ILK ILKAP ILVBL IMMP1L IMMP2L IMMT IMP3 IMP4 IMPA1 IMPA2 IMPACT IMPAD1 IMPDH1 IMPDH2 INADL INCENP INF2 ING1 ING2 ING3 ING4 ING5 INHA INO80 INO80C INO80E
3
6
4
2
5
2
2
3
4
1 1
2 2
4
8 3 11 3 1
1
1 1 2
2 5 1
2 7
12 2
7 1
5 7 1 1 11 2
2 10 10 3 21 2
1
3 2
2 1 1
3 4 3
2 5
2 1 9
1
4
2 4
1 5
6 12 3
2 1
1
7
1
5
1 4 2
2
1
III III II III II III III III II + III III II II II III II + III II + III III II + III II + III II II III II + III II + III II II
III III II III II + III II III III
II + III II + III III
INPP1 INPP4A INPP5A INPP5B INPP5E INPP5F INPP5J INPP5K INPPL1 INSIG1 INSIG2 INSL4 INSR INTS1 INTS10 INTS12 INTS2 INTS3 INTS4 INTS5 INTS6 INTS7 INTS8 INTS9 INVS IP6K1 IP6K2 IPO11 IPO13 IPO4 IPO5 IPO7 IPO8 IPO9 IPP IPPK IQCB1 IQCC IQCE IQGAP1 IQGAP3 IQSEC1 IRAK1 IRAK4 IREB2 IRF1 IRF2 IRF2BP1 IRF2BP2 IRF2BPL IRF3
1 2
1
2 1 4 1 6
1 9 4 1
1 14 4
4 1
3 1 2 1
3
3
3 1 4 4 2 2
4 1
5 1 1
14 6 3
1 4 2
2 2 7 1
2 5 17 4 2 9 3 5 9 6 3
5
3
1 1 3 3 4
2 2 3 9 1 4 1
1 2 2
1 2 2 5 1
1
11 4
3 9 10 1
3 1 1 3 4 2 13 6 1 4 1 1 14 16 16 2
III II + III II + III II II III III III III II + III III II II + III II III II III II II + III III II III III II II III III III II
II II + III II + III III III II + III II II II II + III II
IRF9 IRGQ IRS1 IRS2 IRX3 IRX5 ISCA2 ISCU ISG15 ISG20 ISG20L2 ISL2 ISOC1 ISOC2 IST1 ITCH ITFG1 ITFG2 ITFG3 ITGA2B ITGA3 ITGA5 ITGA6 ITGAE ITGAV ITGB1 ITGB1BP1 ITGB3BP ITGB5 ITGB8 ITM2B ITM2C ITPA ITPK1 ITPKA ITPKB ITPKC ITPR1 ITPR2 ITPR3 ITPRIP ITPRIPL2 ITSN1 ITSN2 IVD IVNS1ABP IWS1 JAG1 JAG2 JAGN1 JAK1
2 6 13 1 1
8 8 1 3
3 19 31 8 5 1 1
1 2 1 1 4
1
7 2
1
2 4 1 1
4
3
5 9
6 16
13 16 3
2
1 3
2 2
2
3 4
3 2 1 1 2 1 3 2 10 4
2
1 1 2
5 2
3
4 12 3 6 1 4
1 15 22
1 2 1 25 25
4 1 1
7 1 1
16 6 1
4 3 1
2 3 2
4 7 1
1 2 35 37 2
II III
II II + III III II + III II III II + III II + III III II + III II II + III II + III III II + III II II III II + III III III III III III III
II + III III II II
JAK2 JARID2 JAZF1 JDP2 JKAMP JMJD1C JMJD4 JMJD6 JMJD8 JMY JOSD1 JOSD2 JPH1 JPH3 JRK JRKL JTB JUN JUNB JUND JUP KANK1 KANK2 KANK4 KANSL1 KANSL1L KANSL2 KANSL3 KARS KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KATNA1 KATNAL1 KATNAL2 KATNB1 KAZALD1 KAZN KBTBD2 KBTBD4 KBTBD6 KBTBD7 KCMF1 KCNAB2 KCNG1 KCNK1 KCNK15
1
1 1
1 7 1 1 2 2
3 2 2
2 7 3 4 1 11 1 1 5 6 6
1 3 1
6 9 2 1 5 1 2
1 1 4 3 11 7 2 2 1 9
1 1 3
3 2 2
5
5 1
7 12 3 1 6 3 14 17 3 2 5 6 16 3 1 6 4 5
17 1 2 1
1 1
3 2 1 4 3
2 1 4 2 5 1
1 3 1 4 1 2 11 4 9 1
III III
II + III III II + III III II + III II + III
II III II II II II II III II
III
II II + III II
II + III II III II III II + III II + III III II III
KCNN4 KCNQ1 KCNS3 KCTD1 KCTD10 KCTD11 KCTD12 KCTD13 KCTD15 KCTD17 KCTD18 KCTD2 KCTD20 KCTD21 KCTD3 KCTD5 KCTD6 KCTD7 KDELC1 KDELC2 KDELR1 KDELR2 KDELR3 KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM5A KDM5B KDM5C KDM6A KDM6B KDM8 KDSR KEAP1 KHDC1 KHDRBS1 KHK KHNYN KHSRP KIAA0020 KIAA0040 KIAA0100 KIAA0101 KIAA0141 KIAA0146
1
4 1 1 1 2 1
5 2 4
11 5 7 8 1 10 2
1 1
2 5 2 1 4
10 7 5 2 13
1
1
2
2 3 5 2 1
1 10 18 3 1
3
6 1 1 5
2 3 2
2 4 4 9 1
1 1
2
1
2
4 9 12 4 2 1 15 4 3 9 1 3 1 6 3 10 11 11 1 2 2 1 1
1 9
3 6 1 3 9
11 17 2 10 17
1
1
2 4
1
2
II III
II + III II + III II II + III
II II + III
III II II II + III
II + III II II + III III
III
III II + III III III II + III
III
III II + III III
KIAA0182 KIAA0195 KIAA0196 KIAA0226 KIAA0232 KIAA0240 KIAA0247 KIAA0284 KIAA0317 KIAA0319L KIAA0355 KIAA0368 KIAA0391 KIAA0430 KIAA0494 KIAA0513 KIAA0528 KIAA0556 KIAA0564 KIAA0586 KIAA0664 KIAA0753 KIAA0754 KIAA0825 KIAA0895 KIAA0895L KIAA0907 KIAA0913 KIAA0922 KIAA0930 KIAA0947 KIAA1009 KIAA1033 KIAA1109 KIAA1143 KIAA1147 KIAA1161 KIAA1191 KIAA1211 KIAA1244 KIAA1274 KIAA1279 KIAA1324L KIAA1429 KIAA1430 KIAA1432 KIAA1467 KIAA1468 KIAA1522 KIAA1524 KIAA1549 KIAA1586
4
2
6 2
1 1
1 2 3
5 1
7 3 4 4 2 1
4 6 9 1 5 4 2 5 2 2
1 1
3 3
6 9 2
1 6 2
5 1
1
4
4 1
2
5 2 2 16 13
1 2 8
1 3 5 1
1 8 3
2 4 1
1
7 2 1 2
2
1
2
2 2 1 6 1 4
1 11 3 8 1
8 1 5 3 8 8
III II III II + III II + III II + III III II + III II II + III II + III III II + III III III III
II II + III III II III III III III II + III II II II III II + III
III
II II III II III III III
KIAA1598 KIAA1609 KIAA1644 KIAA1704 KIAA1715 KIAA1731 KIAA1737 KIAA1804 KIAA1841 KIAA1919 KIAA1958 KIAA1967 KIAA2013 KIAA2026 KIDINS220 KIF11 KIF13A KIF13B KIF14 KIF15 KIF16B KIF18A KIF18B KIF1B KIF1C KIF20A KIF20B KIF21A KIF22 KIF23 KIF24 KIF26A KIF26B KIF2A KIF2C KIF3A KIF3B KIF3C KIF4A KIF5B KIF7 KIF9 KIFAP3 KIFC1 KIFC3 KIN KIRREL KITLG KLC1 KLC2 KLC3
1 3
5
13
1 2 1
1 1 7
2 4 7 10
4
1 7 3 10 5 6
2
3
3 1 5
24 5 20 6 5 4 9
1 1 1 1 1
2 6 1 1 2
3 5 3 1
2 1 7 10 10 3
1
1
3 5 5 2 2
1 7 6 8 1 4
2 1 3
1
14 4 2 5 1
4 1
1 5
8 5
6 2
15
25 2 1 3
III
II + III II II + III II + III II II + III
II III III III II + III III
III II + III
II + III
II + III
III II + III II + III
II + III II + III III II + III III II II III III III
KLC4 KLF10 KLF11 KLF13 KLF15 KLF16 KLF3 KLF4 KLF5 KLF6 KLF7 KLF9 KLHDC10 KLHDC2 KLHDC3 KLHDC4 KLHDC5 KLHDC8B KLHL11 KLHL12 KLHL13 KLHL15 KLHL17 KLHL18 KLHL2 KLHL20 KLHL21 KLHL22 KLHL24 KLHL25 KLHL26 KLHL28 KLHL29 KLHL35 KLHL36 KLHL5 KLHL7 KLHL8 KLHL9 KNTC1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA5 KPNA6 KPNB1 KPTN KRAS KRBA1 KRCC1
12 1 2 6 3 2 1 1
3 2 11 1 4 3 5 3 1 2 3
1 1
1
1 1
4 1 10
5 8 28 4 9 6 13 4 2 3 2 2 1 1 9 4 4 2
1
5
9
15
1
2 16 1 3 5 9 3 6
1 3
2 1
9 3
1
1
1 9
3
9 4 4 1
3
1
2 2
2
11 1 2 2
9 7
12 4 6 2 1 19 13
4
III III III III III III II III II III III III III II III II + III
III III II II III III II II III II III III III III III III II II + III II II II III II III II II + III II + III III
KRI1 KRIT1 KRR1 KRT10 KRT17 KRT18 KRT7 KRT8 KRT80 KRTCAP2 KSR1 KTN1 KXD1 KYNU L1CAM L2HGDH L3MBTL2 L3MBTL3 LACE1 LACTB LACTB2 LAGE3 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC3 LAMP1 LAMP2 LAMTOR1 LAMTOR2 LAMTOR3 LANCL1 LANCL2 LAP3 LAPTM4A LAPTM4B LARP1 LARP1B LARP4 LARP4B LARP6 LARP7 LARS LARS2 LAS1L LASP1 LATS1 LATS2 LBH
4 1 2 1 1 4 3
2 1 9 2
10
19
3
2
3 4 1 1
6 2
1
7 3 13 5 2 3
1
2 1
7 1 1 4
4 1 3 1 1
17 1 9
7 3 1 1 7 4 3 2 2 1
1
5 14 1 2 1
6 1 25 3 8 3
4 1 32 4 11 3
2 2
4
1 7
2 3 11
6 6 17
7 22 14
II II III II + III II II III III II + III III II II II + III II II + III III II II + III III II III II II + III II II II III III II
III II + III II + III III II + III III II + III III
II II II + III III III II
LBR LCLAT1 LCMT1 LCMT2 LCORL LDB1 LDHA LDHB LDHD LDLR LDLRAD3 LDLRAP1 LDOC1 LDOC1L LEMD2 LEMD3 LENG1 LENG8 LENG9 LEO1 LEPR LEPRE1 LEPREL1 LEPREL2 LEPREL4 LEPROTL1 LETM1 LETMD1 LGALS1 LGALS3 LGALS3BP LGALS8 LGALSL LGMN LGR4 LHFP LHFPL2 LHPP LHX2 LHX4 LIAS LIFR LIG1 LIG3 LIG4 LIMA1 LIMCH1 LIMD1 LIME1 LIMK1 LIMK2
1 1
7 11
5 9
1 1
1 2 5 4
3 2 9 5 3
13 1 2 3 16 4 3 1 1 2
16 2 6 3 37 6 4 1 3 1
2 3 1 4 1
3 1 1 4 1 5 1
1 3 4 2 6 2 10 1
13
20
7 1 12 1 1 16 2 3 1 2
3
1 1 5
1 24 3 1
1
1 9 1 1
10 2 9
1
1 1
6 6
11 1
17 2 3 3 6 10 12 2 2 3
3
2 4 3
1 6 11 4
1
1 1
III III
III III III II + III III III II III II + III III II + III III III
II III III III III II II + III III III II II III II III III II II + III II + III
III III III
LIMS1 LIN37 LIN52 LIN54 LIN7B LIN7C LIN9 LINC00085 LINC00094 LINC00116 LINC00162 LINC00263 LINC00265 LINC00319 LINC00339 LINC00467 LINC00473 LINC00493 LINS LIPA LIPT1 LIPT2 LITAF LIX1L LLGL1 LLGL2 LMAN1 LMAN2 LMAN2L LMBR1 LMBR1L LMBRD1 LMBRD2 LMF2 LMNA LMNB1 LMNB2 LMO1 LMO4 LMO7 LMTK2 LNP1 LNPEP LNX2 LOC100128822 LOC100128881 LOC100129250 LOC100129361 LOC100129917 LOC100130093 LOC100130776
2 2
1
1 2
1 7 5 1 1
1
1 1 4
15
21
1 4 3 7 1 1 33
1
2
1
2
1 2
1
1
2
3
2 3 1 9
1 4
1 4
2
1
2 2 5 3 5
1 10
2 1 12
2 3 15
7 1
8 3
1
4
1
3
3
1 5
1
3
4 4 4 9 1
III III III
III
II + III III III III III II III III II + III III III II + III II + III III III
II + III III III
III III III III II
LOC100131089 LOC100132352 LOC100216545 LOC100270746 LOC100271722 LOC100287015 LOC100287177 LOC100287482 LOC100288842 LOC100288911 LOC100289092 LOC100289341 LOC100289361 LOC100292680 LOC100505483 LOC100505666 LOC100505761 LOC100505783 LOC100505876 LOC100506033 LOC100506054 LOC100506100 LOC100506190 LOC100506233 LOC100506451 LOC100506548 LOC100506668 LOC100506688 LOC100506710 LOC100506714 LOC100506844 LOC100506930 LOC100507217 LOC100507246 LOC100507410 LOC100652730 LOC147727 LOC148189 LOC148413 LOC152217 LOC202781 LOC284023 LOC284751 LOC285074 LOC286467 LOC338799 LOC339803 LOC375295 LOC387647 LOC388796 LOC389641 LOC400027
1
1
1 1
1
1 2
2
1
8 1
2
1
4
7
3
2 1
3
1
1 2
11 1 1 3 9 2 12
3 3 6
1
1
2
2 1
2 1
1 1 2 1 1
1
3 1
1 1 1
III III
III
III II + III III III III II + III
III III III III
II II
II II III III II II
II II II II III III II + III II + III
LOC400657 LOC401397 LOC401588 LOC440288 LOC440434 LOC440944 LOC493754 LOC550112 LOC550643 LOC554206 LOC642852 LOC644656 LOC645212 LOC645249 LOC645638 LOC646719 LOC647946 LOC728190 LOC728431 LOC728554 LOC728613 LOC729013 LOC729852 LOC81691 LOC92249 LOC93622 LOC96610 LOH12CR1 LONP1 LONP2 LONRF1 LONRF3 LOX LOXL2 LPCAT1 LPCAT3 LPCAT4 LPGAT1 LPHN1 LPIN1 LPIN2 LPL LPP LPPR2 LRBA LRCH1 LRCH3 LRCH4 LRFN3 LRFN4 LRIF1 LRIG1
1
3
1 2 1 3
1 1 2
7
5
13
2
1
2 1 2 2 1 4
1
2 1
4 11
2 15 2
4 2 6 1 7 4 1 8 1 2 25 3
2 4
3 12
6 28
4 1 1
15 2 1
1
1
4 22
6 25 3
14 4 4 1 4 1 1 11 33 1 2
1 5 2
2 3 2
II + III
II III II II II + III II II
II + III
III III
III III III
II II + III II + III II + III II + III II + III III III II + III III III III III II + III III III II III III II III
LRIG2 LRIG3 LRP1 LRP10 LRP11 LRP12 LRP3 LRP4 LRP5 LRP6 LRP8 LRPAP1 LRPPRC LRR1 LRRC1 LRRC14 LRRC16A LRRC20 LRRC23 LRRC28 LRRC40 LRRC41 LRRC42 LRRC45 LRRC47 LRRC49 LRRC57 LRRC58 LRRC59 LRRC61 LRRC8A LRRC8C LRRC8D LRRC8E LRRFIP1 LRRFIP2 LRRN2 LRSAM1 LRTOMT LRWD1 LSG1 LSM1 LSM10 LSM11 LSM12 LSM14A LSM14B LSM2 LSM3 LSM4 LSM5
2 1 2
2 3 2 1 6
5
4 1 3 3 2 1 3 3 6 5 2 3
1 1 1 1 1
1
4 1 6 4 5 7 2 4 11 6 4 2 4 17 1 1 1 6
1 2 1
7 1
1 8 13 4 26 6 9 8 1 5 16 2
1
1
1
2
1
2
5 2 2 1 3 2
2
1
6 2 12 1 2 1 1 1 4
5 13 1 10 4 5 3
1
1
III III III III III III III III II III III III III II + III III II III
II III III III III III III III III III III III III II II II III III III II + III III II + III II III II II
LSM6 LSM7 LSMD1 LSR LSS LTA4H LTBP1 LTBP3 LTBP4 LTBR LTN1 LTV1 LUC7L LUC7L2 LUC7L3 LUZP1 LY6E LY6K LYAR LYN LYPD1 LYPD3 LYPD6 LYPLA1 LYPLA2 LYPLAL1 LYRM1 LYRM2 LYRM4 LYRM5 LYRM7 LYSMD1 LYSMD2 LYSMD3 LZIC LZTFL1 LZTR1 LZTS2 M6PR MACF1 MACROD1 MAD1L1 MAD2L1 MAD2L1BP MAD2L2 MADD MAEA MAF1 MAFG MAFK MAGEA1
1
1 1 1
11
2 2 1 2 1
12 1
12 2 1
4
2 3 24 1 2 1 3 2 7 1
5 3 2
7
4
5
1 1 3
1
2 1
1 2 2
1
1 2
3
4
3 2 1 1
1
1 1
2
3 1
1 3 5 6 2
5 1
1 5 8 1 1 1 2 1 1 4 7 1 5 16 5
III III II + III
III III II III II III
II + III II + III
II + III II III III II III II II + III II + III III III III II + III II III II II + III III III II II III II II + III II + III
MAGEB2 MAGED2 MAGEF1 MAGI1 MAGI3 MAGOH MAGOHB MAGT1 MAK16 MALAT1 MALSU1 MALT1 MAMDC2 MAML1 MAML3 MAMLD1 MAN1A1 MAN1A2 MAN1B1 MAN2A1 MAN2A2 MAN2B1 MAN2B2 MAN2C1 MANBA MANBAL MANEA MANEAL MANF MANSC1 MAOB MAP1B MAP1LC3B MAP1S MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5
1
2
1 1 2
1
3 1 29
4 4 32
2
3
1 3
8 1
5 1
5 2
21 16 2 1 10 8 4 2
1
1 1
7
1 1 1 2
2 3 6 2
5 2 2 5 2 9 2
1 5 1
8 1
1 1
1 3 1
21 3 2 7 8 1
3 1 2 3
9 3 4 5
2 3 5 1 2
2 6 5 7 5
2 3
2 2 2
III
II III III III II II III II II II II III II + III
III III III III III II III III II II III III III
III
II III
III III II II + III
MAP3K6 MAP3K7 MAP3K8 MAP3K9 MAP4 MAP4K2 MAP4K3 MAP4K4 MAP4K5 MAP6D1 MAP7 MAP7D1 MAP7D3 MAPK1 MAPK11 MAPK12 MAPK14 MAPK1IP1L MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MAPKAP1 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPKBP1 MAPRE1 MAPRE2 MAPRE3 MARC1 MARC2 MARCH2 MARCH3 MARCH5 MARCH6 MARCH7 MARCH8 MARCH9 MARCKS MARCKSL1 MARK1 MARK2 MARK3 MARK4 MARS MARS2
1
3 2
5 5 1 1
1 1 2 2 1 2
1 1
1
8
2
4 5
2 1 1
1
2
1 1
3 2 3 4 4 3 2
5
1
1 1
1 1 2 1 3 4 1 1 3
3 3 1 2 8 2 5 3 8 1 5 5 9 1 3 1 5 8 4 1 7 4 2 2 2 1 1 2 10 3 3 3 5 2 1 13 5 3 5 10
II + III
II + III III III III II II III II
III II II + III II III II + III II + III II + III II
II + III II III III III III II + III II + III II II III II II
MARVELD1 MAST2 MAST3 MASTL MAT2A MAT2B MATK MATN3 MATR3 MAU2 MAVS MAX MAZ MB21D1 MB21D2 MBD1 MBD2 MBD3 MBD4 MBD5 MBD6 MBIP MBLAC2 MBNL1 MBNL2 MBNL3 MBOAT1 MBOAT2 MBOAT7 MBP MBTD1 MBTPS1 MBTPS2 MC1R MCAM MCAT MCCC1 MCCC2 MCEE MCF2L MCFD2 MCI MCL1 MCM10 MCM2 MCM3 MCM3AP MCM4 MCM5 MCM6 MCM7
3 2
2
1
4
7 1
8 2 1 1 6 1 2 3 1 7 1
1
4
2 1
12 6 1 1
2 2 3
2 2 5
3 11 2
12 2 1 4 6 11 19 1 1
1
2
11 1 5 1
14 1 2 2
2 4
3
1
4
5 4 1 8
7 6 6 2 16 2 4 4 1 22 5 4 6 1 16 8 1 4 1 19 6 5 9 18 26 3 1 1 4 3 24 3 5 5 8 5 4 1 7
III
III III III II III II III II + III II III III III III III II III II + III II III II + III II + III II III III III III II III III II + III III III II III III III II
MCM8 MCMBP MCOLN1 MCOLN2 MCPH1 MCRS1 MCTS1 MCU MDC1 MDFIC MDH1 MDH2 MDM1 MDM2 MDM4 MDN1 MDP1 ME1 ME2 MEA1 MEAF6 MECOM MECP2 MECR MED1 MED10 MED11 MED12 MED13 MED13L MED14 MED15 MED16 MED17 MED18 MED19 MED20 MED21 MED22 MED23 MED24 MED25 MED26 MED27 MED28 MED29 MED30 MED31 MED4 MED6 MED7
1 1 1 1 2
1 2 2 3
5
1 10
2 22
2
1 2
3 3 1 9 9 2
4 1
3 2 1
1
2 1
2
2
1 1
4 3 1
1 3 6 1
1
10 8 2 1 1
1 1
3 10 19 8 3 4 24 21 4 3 4 1 1 2 2 5
1 1
4 1
1
1
10 1 1 4
1
1
3
III II III III II + III II + III II II II + III II + III II + III II + III
II III II III II II III II III III III III III III
II + III II III II + III III III II + III
MED8 MED9 MEF2A MEF2BNB MEF2D MEGF8 MEGF9 MEIS1 MEIS2 MELK MEMO1 MEN1 MEPCE MESDC1 MESDC2 MET METAP1 METAP1D METAP2 METRN METRNL METTL1 METTL10 METTL13 METTL14 METTL16 METTL17 METTL18 METTL21A METTL21B METTL21D METTL22 METTL23 METTL2A METTL2B METTL3 METTL4 METTL5 METTL6 METTL7A METTL8 METTL9 MEX3C MEX3D MFAP1 MFAP2 MFAP3 MFF MFGE8 MFHAS1 MFN1
1
9
1 1 1 1 2 11
1 1
2 1
2 5 4 3 7
1 7 3 8 8
1
1
4 1
2
1 2
3 1 2
2
1 1 1 1 3
1 6 3 4 3 12 5 1 2 2 18 9 8 19 1 1 4 3 2 1 4 2 5
5 1 1 2 1 1
1
4 3 7 1
1 1 4 11 13 2
6
9 1
18 1
13
27
34
4 4
II III II II III III II + III
II + III II + III II + III II + III II II + III III II + III III III II III III III II III II III II II III II + III II + III II III III III II + III III III II III
III III
MFN2 MFSD1 MFSD10 MFSD11 MFSD12 MFSD2A MFSD3 MFSD5 MFSD6 MFSD8 MFSD9 MGA MGAT1 MGAT2 MGAT4B MGAT5 MGAT5B MGC2752 MGC39372 MGC72080 MGEA5 MGMT MGRN1 MGST1 MGST2 MGST3 MIA3 MIB1 MIB2 MICA MICAL1 MICAL3 MICALL1 MICALL2 MICU1 MID1 MID1IP1 MIDN MIEN1 MIER1 MIER2 MIER3 MIF4GD MIIP MINA MINK1 MINOS1 MINPP1 MIOS MIPEP MIPOL1
2
1
5
1
1 1 5
2 1 5 1 1 12 3
1 1 5 1 1 13 10 3 5 1 1
1
9
1 22 17 5 4 6 1 2
4 36 28 14 10 7 4 9 4
1
3
3
2 2 1 1 5
1 1
2 1
1
1
1
5 1
6 3
18 5 1
1 2 3 2
2 9 1
7 16 4
1 2 1
2 2 4 2
1
1
1 1
1
2 2 1 4 2 1
III III III III III II + III II III II II + III II + III III II III III III II III III II III II II II II II II II III
III II II II III III III III III II III III II + III
MIR100HG MIR31HG MIS18A MIS18BP1 MITD1 MITF MKI67 MKI67IP MKKS MKL1 MKL2 MKLN1 MKNK1 MKNK2 MKRN1 MKRN2 MKRN3 MKS1 MKX MLEC MLF1 MLF1IP MLF2 MLH1 MLH3 MLKL MLL MLL2 MLL3 MLL4 MLL5 MLLT1 MLLT10 MLLT11 MLLT3 MLLT4 MLLT6 MLST8 MLX MLXIP MLYCD MMAB MMACHC MMADHC MMD MMGT1 MMP15 MMP17 MMP24 MMS19 MMS22L
1
1 2 1 2
1 6
4 22
6 33 1
3 3 1
6 4 1
1
2 2 2
12 11 8 1 7 2 1
11
1 10
9 18
3
6
6
2 1 12 24 3 3 6 4
1 15 36 2 3 8 16
3 2 7
2 3 5 8 3
1
2
1
3 3
1
2 4 24 62 15 14 21 24 3 2 1 8 4 7 33 1 2 2 1 4 6 1 2 4
II + III III III III III III III
II + III III II II + III II
III III III III III III II II III III III III III III III III III III
II III III III II II
MN1 MNAT1 MND1 MNF1 MNT MOAP1 MOB1A MOB1B MOB2 MOB3A MOB3B MOB3C MOCOS MOCS2 MOCS3 MOGS MON1A MON2 MORC2 MORC3 MORC4 MORF4L1 MORF4L2 MORN1 MORN2 MOSPD1 MOSPD2 MOSPD3 MOV10 MPDU1 MPDZ MPG MPHOSPH10 MPHOSPH6 MPHOSPH8 MPHOSPH9 MPI MPLKIP MPP1 MPP2 MPP3 MPP5 MPP6 MPP7 MPPE1 MPRIP MPST MPV17 MPV17L2 MPZL1 MRAS
4
10 1
13 1
1
2 10
1 1 1
2 5 2
1
1
5
4
3 4
1 1
1 1
8 7 3 3 4
1 1 3 1
1 1 3 3
1
2 1 2 2 5 1
1 1 3
1 6
1 1
2 2
2 5
1 1
2 1 3 1
3
4
14
1 1
2 1 1 2
5 9 12
III III III II II III II + III III II III III III III III III III III III III III III III III III III III III II + III II II II III III III III III III III III III III III III III
MRC2 MRE11A MREG MRFAP1 MRFAP1L1 MRI1 MRM1 MRP63 MRPL1 MRPL10 MRPL11 MRPL12 MRPL13 MRPL14 MRPL15 MRPL16 MRPL17 MRPL18 MRPL19 MRPL2 MRPL20 MRPL21 MRPL22 MRPL23 MRPL24 MRPL27 MRPL28 MRPL3 MRPL30 MRPL32 MRPL33 MRPL34 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL41 MRPL42 MRPL43 MRPL44 MRPL45 MRPL45P2 MRPL46 MRPL47 MRPL48 MRPL49 MRPL50 MRPL51
1
2
2
2
2
2
1 5 1 2
1
1
1
2
1
1
1
3
2
5 1 2 1
2 2
1 1
2 1
4 1
2 2 1 5 1
4 5 4 4 2
1
1 2
1
2 1 1 1 1
1 3
1 1 1
1 1 1 3
III III III III III III III II III III III III III III II II III III II III II III II III III II III III III III III III III III II + III II + III
II II + III II + III III III II + III II III II + III
MRPL52 MRPL53 MRPL54 MRPL55 MRPL9 MRPS10 MRPS11 MRPS12 MRPS14 MRPS15 MRPS16 MRPS17 MRPS18A MRPS18B MRPS18C MRPS2 MRPS21 MRPS22 MRPS23 MRPS25 MRPS26 MRPS27 MRPS28 MRPS30 MRPS31 MRPS33 MRPS34 MRPS35 MRPS36 MRPS5 MRPS7 MRPS9 MRRF MRS2 MRTO4 MSANTD2 MSANTD3 MSANTD4 MSH2 MSH3 MSH6 MSI2 MSL1 MSL2 MSL3 MSL3P1 MSLN MSMO1 MSN MSRA MSRB1
3
3
1 3
1 6
4 6
3 1 2
1 5 1 3 4
8 1
8 2 1
2 3
2 1 4
1
3
11 3 2 1 1 3 6 1 9
4
5 2
5 1
1 1
1 3
3
7 1 2 3 4 5 1
3 1 1 2
1 3 2
3 1 1
3 1 8 4
1 2 1 6
3 9
1
1
5 2 10 18 2 1 10 1 3
III III II III III III III III III III III II III II
III II + III II III II III III III II III II + III III III
III II III II + III
III
MSRB2 MSRB3 MST4 MSX1 MSX2 MT1E MT1X MT2A MTA1 MTA2 MTA3 MTAP MTBP MTCH1 MTCH2 MTCP1NB MTDH MTERF MTERFD1 MTERFD2 MTERFD3 MTF1 MTF2 MTFMT MTFP1 MTFR1 MTG1 MTHFD1 MTHFD1L MTHFD2 MTHFR MTHFSD MTIF2 MTIF3 MTM1 MTMR1 MTMR10 MTMR11 MTMR12 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR9 MTMR9LP MTO1 MTOR MTPAP MTR MTRF1
1
1 1 1 3
1 4 3 6 1
1
2 2 4
1
3
1
1
1 1
2
8
11
1 3 1
3 1
9 3
2
2
5 2
2 1
2 8 2 8 11 1
1 2 1
1 6
1 1 1 1
1
2
4 1
1 2 4 2
3 4 2 4 1 4 13
2 1 8 4 1
III II II III III II + III II + III III III III III III III II III III II III III II II + III III II II III II III III III III III II
II
II + III II + III
MTRF1L MTRR MTSS1L MTUS1 MTX1 MTX2 MTX3 MUC1 MUL1 MUM1 MUS81 MUT MUTYH MVD MVK MVP MXD1 MXD3 MXD4 MXI1 MXRA7 MYADM MYBBP1A MYBL1 MYBL2 MYC MYCBP2 MYEOV2 MYH10 MYH9 MYL12A MYL12B MYL5 MYL6 MYL6B MYL9 MYLIP MYLK3 MYNN MYO10 MYO19 MYO1B MYO1C MYO1D MYO1E MYO5A MYO6 MYO9A MYO9B MYOF MYPN
4
6 17
1
1
1 12 30 1 2
1 5 2
4 3 1
4 12 11 1 1
1 1
1 1
1 2
3
5
1 7
1 8
2 10 1
1 5
1 6 1 3
1
1 8 1 2 6 3 1 9 15
1 9 1 2 2
2
5 5 4 13 3
5
5
5
4
6
2
7 2
2 9 1 2
3 22 3 5
5 2
III III III
III II II III II II + III III II + III III II III II + III II II II III III III
III
III III III II III III III III III II + III
MYSM1 MZF1 MZT1 MZT2A MZT2B N4BP1 N4BP2 N4BP2L2 N4BP3 N6AMT1 N6AMT2 NAA10 NAA15 NAA16 NAA20 NAA25 NAA30 NAA35 NAA38 NAA40 NAA50 NAA60 NAAA NAB1 NAB2 NACA NACC1 NACC2 NADK NADKD1 NADSYN1 NAE1 NAF1 NAGA NAGK NAGLU NAGPA NAIF1 NAMPT NANP NANS NAP1L1 NAP1L4 NAP1L5 NAPA NAPEPLD NAPG NAPRT1 NARF NARFL NARG2
1
2 1
2 2 1 1
1 2 1 1 1 3 1
1 1 2 1 1 2 2
3 6 1 1 2 5 3 14 2 1
2
3 5 1 6 1 2 7 1 2 2 2 1 1 14 3 12 3 8 3 33 14 1 1
1 1 4
1 3
1
5 1 4
1
5
1 6
1 1 7 2
1
2 1
3
1 2
III III III II III II III II + III
III III
II III III III II III III II + III
II III II II II + III II + III II + III II + III II II II + III II II + III III II III II III
NARS NARS2 NASP NAT1 NAT10 NAT14 NAT6 NAT8L NAT9 NAV1 NAV2 NBAS NBEA NBEAL1 NBEAL2 NBN NBPF3 NBR1 NCAPD2 NCAPD3 NCAPG NCAPG2 NCAPH NCAPH2 NCBP1 NCBP2 NCDN NCEH1 NCK1 NCK2 NCKAP1 NCKAP5 NCKAP5L NCKIPSD NCL NCLN NCOA1 NCOA2 NCOA3 NCOA4 NCOA5 NCOA6 NCOA7 NCOR1 NCOR2 NCR3LG1 NCS1 NCSTN NDC80 NDE1 NDEL1
1
2 2 2
1
3
5
9 1 3
12 5 13 8 1
1
2 1 5 3
3
1 1
1 1
2
1 4
2 1 2
1
3 4 13 1 1 2 1 2 2 3 6 1 1 3
1 7
2 1 1 1 5 1 2 4 7 1 1
4 21 1 1 3 4 4 8 6 4 5 3 4 1
4 15 3 8 15 3 8 8 3 10 14 10 10 15 6 6 4
2 3
6 6
III III II + III II III III III II II + III III III III II III II III III III III III III III III III III III III III III III III II III III II III III III III III III III III III III II III II II
NDFIP1 NDFIP2 NDNL2 NDOR1 NDRG1 NDRG2 NDRG3 NDST1 NDST2 NDUFA1 NDUFA10 NDUFA11 NDUFA12 NDUFA13 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFAF1 NDUFAF2 NDUFAF3 NDUFAF4 NDUFB1 NDUFB10 NDUFB11 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFB9 NDUFC1 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS5 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NDUFV3 NEAT1
1 2 6
8 1
1 18 1
1 1 7 27 3
1 12 1
2 20 2 1
3 1 1 1
1 1
2 1
1 1 1
2 1 1
1 1 1 2 1 2
1
1 1
1
1
2
2
1 1
1 1
1
1 1 1 1
2 1 1
1 1
1
1
1
1 7
1 14
1 2 2 12
II III II + III
III III III III II
III III II II III II + III II II + III III III III II + III II II II + III II II + III II + III II + III II + III II II II + III III III III III III
NECAB3 NECAP1 NECAP2 NEDD1 NEDD4 NEDD4L NEDD9 NEIL2 NEIL3 NEK1 NEK2 NEK3 NEK4 NEK6 NEK7 NEK9 NELF NELL2 NEMF NENF NEO1 NES NET1 NETO2 NEU1 NEU3 NEURL NEURL1B NEURL4 NEXN NF1 NF2 NFAT5 NFATC1 NFATC2IP NFATC3 NFE2L1 NFE2L2 NFIA NFIB NFIC NFIL3 NFIX NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIL1 NFKBIZ NFRKB
4 1 2
3
1
2
2 2 2
2
1
2 1
4 3
1
2 7 1
2 4
2 11
3 13
1 8 2
1 4 6 6 1
3 11 10 11 4 1 1 1 8 4 27 4 3 12 36 11 8 7 32 9 8 5 2 2 1
2
1 2 2 1 1 1 3 14 2 1 1 13 2
3 2 16 3 2 9 35 7 1 4 17 5 4 1 1 2
1 1
II III
II + III III III III III III II III III III III II + III II + III II
II + III II II + III III III II II III III III II III III II III II
II + III III III III II + III III II
NFS1 NFU1 NFX1 NFXL1 NFYA NFYB NFYC NGDN NGFRAP1 NGLY1 NGRN NHEJ1 NHLRC2 NHLRC3 NHP2 NHP2L1 NHS NIF3L1 NIN NINJ1 NINL NIP7 NIPA1 NIPA2 NIPAL3 NIPBL NIPSNAP1 NIPSNAP3A NISCH NIT1 NIT2 NKAIN1 NKAP NKD2 NKIRAS1 NKIRAS2 NKRF NKTR NKX3-2 NLE1 NLGN2 NLK NLN NLRC5 NLRX1 NMD3 NME1 NME4 NME6 NME7 NMRAL1
2
1
1
1
6
1
1 1 4 1 4 1
2 1 1
5 1
1 2
1 2 1
7
3
1 1 4
1 6
3
4 1
3 1
4 2
1 13 1 7 1 4 9 1 1 10 2 7 6 2 19 2
1
12 3 1 2
1
3
11
1
2 3 2
6 4 5 2 17
1 7
1
3
6 3 2 1
2 5 5 3
1
1 1 2
6
1
1
1
III II III II II + III II II II III II + III III III III II III III II III II II II II III II II III III III II + III II + III III III II III II III III II III III II III II
NMRK1 NMT1 NMT2 NNMT NNT NOA1 NOB1 NOC2L NOC3L NOC4L NOD1 NOG NOL10 NOL11 NOL12 NOL3 NOL6 NOL7 NOL8 NOL9 NOLC1 NOM1 NOMO1 NOMO2 NOMO3 NONO NOP10 NOP14 NOP16 NOP2 NOP56 NOP58 NOSIP NOTCH1 NOTCH2 NOTCH2NL NOV NPAS2 NPAT NPC1 NPC2 NPDC1 NPEPPS NPHP4 NPL NPLOC4 NPM1 NPM3 NPR3 NPRL2 NPRL3
2
5
17
1
2
2 3 1 2
2 1 3 1
3 1 2 3 3 3
1
1 1
1
4
3
5 2 2 3 1 1
2 5 1 4 2 1 1 3 6 3 1 1 6 1 1
5 19
4 24
2
1 3 5 3 1 2 1
4
8 1 9
14 4 1 7
1
1
4 3 3 2 2 5 8 7 3 2 1 3 3 10 4 4 2 4 4 1 11 40 1 4 7 5 1 3 4 2 19 6 15 2
II II + III III III III III III III III III II + III II + III II II + III II
III III II III II + III III III II II + III III III II + III
III III III III III III III II + III II III
NPTN NPTX1 NPTXR NQO1 NQO2 NR1D1 NR1D2 NR1H2 NR1H3 NR2C1 NR2C2 NR2C2AP NR2F1 NR2F2 NR2F6 NR3C1 NR3C2 NR4A1 NR4A2 NR4A3 NRARP NRAS NRBP1 NRBP2 NRCAM NRD1 NREP NRF1 NRG4 NRGN NRIP1 NRM NRP1 NRSN2 NSA2 NSD1 NSDHL NSF NSFL1C NSFP1 NSL1 NSMAF NSMCE1 NSMCE2 NSMCE4A NSRP1 NSUN2 NSUN3 NSUN4 NSUN5 NSUN6
1 12
3 16 2
1 1 1
1 2 1 1 3 5 3
4 2 5 10
1
2
1 2 6 2 1 2
3
1
5 1 1
1 2 1
4
5 1 2 5 2
6 24 1 5 1 5 5 2 4 1 4 5 10 19 2 9 5 4 7 5
3 1 8 1 10 5 4 4 2 19 4 2 1
1 1
1 1 3
1
1 7
4
1
1
3 1
III II III II III II
III III III II III II + III II + III II + III III III III III II III II III III III II + III III III III III III II III III III III III III III III II + III III III II
NT5C NT5C2 NT5C3 NT5C3L NT5DC1 NT5DC2 NT5DC3 NT5E NT5M NTAN1 NTHL1 NTN1 NTN4 NTPCR NTSR1 NUAK1 NUAK2 NUB1 NUBP1 NUBP2 NUBPL NUCB1 NUCB2 NUCKS1 NUDC NUDCD1 NUDCD2 NUDCD3 NUDT1 NUDT12 NUDT13 NUDT14 NUDT15 NUDT16 NUDT16L1 NUDT18 NUDT19 NUDT2 NUDT21 NUDT22 NUDT5 NUDT7 NUDT8 NUDT9 NUF2 NUFIP1 NUFIP2 NUMA1 NUMB NUMBL NUP107
2 2
1 1 3
2
2
1 1
5
6 3 6
1 8 7 7
3 2 6 1 2 8
4 1 19 21 13
1 5
6
2
10 2
1 6 1
11 1
4 1 14 2 1 17 1
2
5
1
1
2 2
1
2
1 1
1 3
17 1 1 1 1
27 2 1 4 5
II + III II + III II II II III III III II + III III II + III III III III III II + III II III II II III II II + III II III II III III II II II III III III III II III III III II + III III III II
NUP133 NUP153 NUP155 NUP160 NUP188 NUP205 NUP210 NUP214 NUP35 NUP37 NUP43 NUP50 NUP54 NUP62 NUP62CL NUP85 NUP88 NUP93 NUP98 NUPL1 NUPL2 NUPR1 NUSAP1 NUTF2 NVL NXF1 NXN NXPH4 NXT1 NXT2 OAF OAS3 OAT OAZ1 OAZ2 OBSCN OBSL1 OCEL1 OCIAD1 OCIAD2 OCRL ODC1 ODF2 ODF2L ODZ3 OFD1 OGDH OGDHL OGFOD1 OGFOD2 OGFR
5 2 1 1 3 3
4 12
2 1
13 4 4 2 1 6 3
6 1 8 2 1 1 7 1 2 1 3 4
21 3 3 6 9 13 1 3 12 22 1 2
2 3 4
2 3 6 1
8 1 6 3 4 5 1 3 9 5 1
1
2
2
1 1 2 2
1 1 5 10
3
1 5
1 1
2 1 4 1
1 4
3
4 1
3
1 2 3
4 4 10
2
4
2
8
4
III II + III III III II + III II II II III III II + III III II II + III III III III III
III III III II II II + III III
III II + III III
III III III
III III III
OGFRL1 OGG1 OGT OIP5 OLA1 OLFM1 OLFM2 OLFML1 OLFML2A OLFML2B OLR1 OMA1 OPA1 OPLAH OPN3 OPTN ORAI1 ORAI2 ORAI3 ORAOV1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 ORMDL1 ORMDL2 ORMDL3 OS9 OSBP OSBP2 OSBPL10 OSBPL11 OSBPL1A OSBPL2 OSBPL3 OSBPL5 OSBPL6 OSBPL8 OSBPL9 OSCP1 OSGEP OSGEPL1 OSGIN1 OSGIN2 OSMR OSR2 OST4 OSTC OSTF1
1 1 14
1 1 21
2
16 2 2 1
1
2
19 4 2 2 1 3
2
13 2
1 1
4
4
2 5
2 2
6 9 1 1 2
3
2 2 1 1
2 6 2 1 2
1
1 2 3 2 1 1 2 8 11 2 6 2
3
5 1
1 1
2 3 1
1 1 7 1 1
9 1 14 4 3 1
III III II II + III III III II III III
II + III III II + III III III II III II II II III III II III III
III III III III II III III III II III III III
OSTM1 OTUB1 OTUD1 OTUD3 OTUD4 OTUD5 OTUD6B OTUD7B OXA1L OXCT1 OXNAD1 OXR1 OXSM OXSR1 P2RX4 P2RY6 P4HA1 P4HA2 P4HB P4HTM PA2G4 PAAF1 PABPC1 PABPC4 PACRGL PACS1 PACS2 PACSIN2 PACSIN3 PAF1 PAFAH1B1 PAFAH1B2 PAFAH1B3 PAFAH2 PAGE1 PAICS PAIP1 PAIP2 PAIP2B PAK1 PAK1IP1 PAK2 PAK4 PALB2 PALLD PALM PAM PAN2 PAN3 PANK1 PANK2
2 1 1 1
1 4 2
5
2 3
2 2 3 1 8 7 1 9 5 1
1
3
1 1
2 1 10
6
3
4
6 1 1
18
3 1
5 2
13 2 7 1 4 3
4
2 1
1 1 3 1 3
1
4 2 1
1
4 1 1
3 4 1 1 1 9 6 7 1 5 3 1
6 1 14 2 3 2 4 2
II + III III II II + III III III III III II + III II II
III III III III III III III III III
III III II II II II + III III
III III III III III III
PANK3 PANK4 PANX1 PAPD4 PAPD5 PAPD7 PAPOLA PAPOLG PAPPA PAPSS1 PAPSS2 PAQR3 PAQR4 PAQR5 PAQR7 PARD3 PARD6A PARD6G PARG PARK7 PARL PARN PARP1 PARP12 PARP14 PARP16 PARP2 PARP3 PARP4 PARP6 PARP8 PARP9 PARPBP PARS2 PARVA PARVB PASD1 PASK PATL1 PATZ1 PAWR PAX9 PAXIP1 PBK PBLD PBRM1 PBX1 PBX3 PBXIP1 PC PCBD1
2
7
1
1
6 2
4 8 2 1
4 4 11 16 3 2 1 3
1
5 1 1 1
8 1 3
15 1 4 2 3 2
1 1 1
2 4 3 3
1 1 1 1 1 1
1 3
1 6
2 7
2 2 2
2 2 2 2 1 6 3 6 1 5 17 1 3 1 2
1
5 3 2
1
1
1
III II + III II III III III II + III III III II + III III II III III III III
III III III II + III II + III II II II II + III
II III III II III III III III II III III III II + III
II + III
PCBD2 PCBP1 PCBP2 PCBP4 PCCA PCCB PCF11 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCID2 PCIF1 PCK2 PCM1 PCMT1 PCMTD1 PCMTD2 PCNA PCNP PCNT PCNX PCNXL3 PCOLCE PCOLCE2 PCSK7 PCSK9 PCTP PCYOX1 PCYOX1L PCYT1A PCYT2 PDAP1 PDCD10 PDCD11 PDCD2 PDCD2L PDCD4 PDCD5 PDCD6IP PDCD7 PDCL PDCL3 PDDC1 PDE10A PDE12 PDE3A PDE3B PDE4A PDE4D
7 5
2 7 11
2 11 12
1
1 2
1 12
1
2 1
4 3
2
2
8 1
1 1 2
1 2
5 10 1
6 13 1
3 2
2 4
2
6
7 1 3 1 10 36 1 1 5 11 2 8
3
1
4
3
3
1 1 1
3
2
1
1 6 2 3 4 4
1 4 1 1 1 1 1
1 2 9 4 7 10 11
III
II + III II + III II II III III III II II III II
III
III III III III II + III II + III II
III III II II II III
II II + III II III III II + III III
PDE4DIP PDE6D PDE7A PDE7B PDE8A PDE8B PDF PDGFA PDGFB PDGFRB PDHA1 PDHB PDHX PDIA3 PDIA4 PDIA5 PDIA6 PDIK1L PDK1 PDK2 PDK3 PDK4 PDLIM1 PDLIM2 PDLIM3 PDLIM5 PDLIM7 PDP1 PDP2 PDPK1 PDRG1 PDS5A PDS5B PDSS1 PDSS2 PDXDC1 PDXDC2P PDXK PDXP PDZD11 PDZD4 PDZD8 PEA15 PEAK1 PEBP1 PECR PEF1 PEG10 PELI1 PELI3 PELO
3 2
7
3
3
2 4 5 2 1
4 1 5 2 1 1
4 2 9 1
2 3
8 3 1 5 1
4 4
1
1
3 2 2 1
2 1
1
2 2 3 5 5 1
4 7 10 6 5 2
6 1
1 1 8 1
4 1 1
1 4 1 1
1 1 22 3 1 2 7 10 8 2
1 11
18
5 40
3
3 5
1 2 1 3
1
II III III II II III III
III
II + III III III III II III III III III III III III III III II + III II II III II II III III II II + III II II III III
II
PELP1 PEMT PEPD PER1 PER3 PERP PES1 PET112 PET117 PEX1 PEX10 PEX11A PEX11B PEX12 PEX13 PEX14 PEX16 PEX19 PEX2 PEX26 PEX3 PEX5 PEX6 PEX7 PFAS PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 PFKFB2 PFKFB3 PFKFB4 PFKL PFKM PFKP PFN1 PFN2 PGAM5 PGAP2 PGBD1 PGBD2 PGD PGGT1B PGK1 PGLS PGM1 PGM2 PGM2L1 PGM3 PGP
5
5 3
1
3
3 1
6
10 2
1 1 2
3 1 4 3 1
2 1
2
1 2 1 2 1
5 5 1 9
1 4 11 1
3 2 1 4 3
1 2 1 1 1
2
4
4 3
2 6 1 1
2 13 2 2 1 10 4 1 12 2 4 2 2
4 4 1 7 1 3 1 1 2
3 2
1 1
8 2
III II
II III II II III III III II + III II II + III II + III II II + III III II + III II III II II
II + III III II II + III III II + III III II III III III
PGPEP1 PGRMC1 PGRMC2 PGS1 PHACTR2 PHACTR4 PHAX PHB PHB2 PHC2 PHC3 PHF1 PHF10 PHF12 PHF13 PHF14 PHF15 PHF16 PHF17 PHF19 PHF2 PHF20 PHF20L1 PHF21A PHF23 PHF3 PHF5A PHF6 PHF7 PHF8 PHGDH PHIP PHKA1 PHKA2 PHKB PHKG2 PHLDA2 PHLDA3 PHLDB1 PHLDB2 PHLDB3 PHLPP1 PHLPP2 PHPT1 PHRF1 PHTF1 PHTF2 PHYH PHYHIP PI4K2A PI4K2B
1 1 4 1 1 2 1
1 1 10 1 1 1
1 1
4 1 2 2 2 5 3 2
3 2 1 12 3 2 1 5 1 2 3 1 2
3 1 9 1 2 5 2 8 5 5 1 1 6 1 4 31 1 3 10 2 12 3 7 16 6 4 4
1 4 1
3 3
13 6 2 1
1
1 2
1 4
3 6
6 8
2
1 2
1
1
1
4 4 12 1 5 8 1 1 2 1 1 4
III III II + III II + III III II III III III III II II III III III III II + III II III II II II III II + III III II III II + III III II + III II II + III II III II II III III III
PI4KA PI4KAP2 PI4KB PIAS1 PIAS2 PIAS3 PIAS4 PIBF1 PICALM PICK1 PIDD PIEZO1 PIF1 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PIGY PIH1D1 PIK3C2A PIK3C2B PIK3C3 PIK3CA PIK3CB PIK3CD PIK3R2 PIK3R3 PIK3R4 PIKFYVE PILRB PIM1 PIM2 PIM3 PIN1 PIN4 PINK1
1 2 1
1 2 1
1
2 2 3 1
10 1 2
11 1
9 8 2 2 5 1 4 3 20 1 3 1
1
8
1 3
1 4
2
3
4 2 5
5 8 4
5 1 5 1 3 10 5
1
1 2
3 1
1
1 1
2
4
1 2 1
2 1
1 2 2 6 1 1 5 4 4
2
4
6
1
1
1 9
1 8 1
2 3 4 9 1 2
III III II + III II + III II II + III III II + III III III II III III II + III III II III III II III II III
III
II + III III III II + III II + III II III II II
III II III
PINX1 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PIR PISD PITHD1 PITPNA PITPNB PITPNC1 PITPNM1 PITRM1 PITX1 PJA1 PJA2 PKD1 PKD2 PKDCC PKIG PKMYT1 PKN1 PKN2 PKN3 PKNOX1 PKP2 PKP3 PKP4 PLA2G12A PLA2G15 PLA2G16 PLA2G4A PLA2G6 PLAA PLAC2 PLAGL1 PLAUR PLBD2 PLCB3 PLCB4 PLCD3 PLCG1 PLCG2 PLCL2 PLD1 PLD2 PLD3 PLD6 PLDN
4 1 5
1 5 6 11
11
15
3
2
3 12 11 14 2 31 2 6
1
3 1
4 1
1 1 6
12
5 16 1 2 15 1 1
2
1 6
2
4
6
1
2 2
3 5 1 4
1 13
10
2
10 3 1 1
1 11 8 1 5
1 1
4 2 1
3 1
5 3
1
1 1
1 3
2 9 4 1 4
1 2 1
II III II III
II + III
III II III
III III II III III II II II II III III III II II III II II
II II III II + III II II III
III III
PLEC PLEK2 PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA7 PLEKHB2 PLEKHF2 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHH3 PLEKHJ1 PLEKHM2 PLEKHO2 PLGRKT PLIN3 PLK1 PLK1S1 PLK2 PLK3 PLK4 PLLP PLOD1 PLOD2 PLOD3 PLP2 PLRG1 PLS1 PLS3 PLSCR1 PLTP PLXNA1 PLXNA3 PLXNB1 PLXNB2 PLXND1 PM20D2 PMAIP1 PMEPA1 PMF1 PMM1 PMM2 PMP22 PMPCA PMPCB PMS1 PMS2 PMS2P1 PMS2P4 PMVK
32
25
1
1
1
1
3 1 3
8
40 1 5 3 3 6 4 4 3 9
1
5 4
2
2 3
1 5 1
1 7
2 2 7
5 3 13
2 3
5 9
3 7
1 1
2 6
1 4 6
4 3
1 3 12 5 3 7 11
3 1
1 9 1
6 14 1
2 2 3
6 10 2
10 7 3
1
2 2
2
1
2 1
III II III II + III III III III III III III II III II II
III II + III II II + III II II + III II + III III III III II III II III II III II III
III II III
PNISR PNKD PNKP PNMA1 PNN PNO1 PNP PNPLA2 PNPLA3 PNPLA4 PNPLA6 PNPLA8 PNPO PNPT1 PNRC1 POC1A POC1B POC5 PODXL PODXL2 POFUT1 POFUT2 POGK POGLUT1 POGZ POLA1 POLA2 POLB POLD1 POLD2 POLD3 POLD4 POLDIP2 POLDIP3 POLE POLE2 POLE3 POLE4 POLG POLG2 POLH POLI POLK POLL POLM POLQ POLR1A POLR1B POLR1C POLR1D POLR1E
1 1
2 1
1 5
2 1
2 1 2 4
2 2
1 1
1
1
1 1
5 1 2
3 2 7 4
14 7 6 1 6
2 20 6 9 2 8
3
11
1 26 12 10 7 16 2 18 1 1
1
1 2 1
3
2 2 1 2 7 2 1
3
7 1 1
1
3
6 1 2
3
3
2 1
1
2
4 1 1 1
1 1 3 10 4 1 3 2
II II III III III III III III III II III III
III II III III III II + III III III II III III III III II III III II III II III III II + III III III III III II
II + III II + III
POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2J3 POLR2J4 POLR2K POLR2L POLR3A POLR3B POLR3C POLR3D POLR3E POLR3F POLR3G POLR3GL POLR3H POLR3K POLRMT POMGNT1 POMP POMT1 POMT2 PON2 POP1 POP4 POP5 POP7 POPDC3 POR PORCN POT1 PP7080 PPA1 PPA2 PPAP2A PPAP2B PPAP2C PPAPDC1B PPAPDC2 PPARA PPARD PPARG PPARGC1A PPARGC1B
6
8
1
3 1 1
19 1 4 7 5 2
1 1 1
1
1 1 1
3 2 3 2 2 2 3 5 1 2 1
1
3
2
4
9
2
3
1 2 2
1
1 3 1 3 2
1 1
2
1 4
2 5
11
3
5
5
8
15
22
2 4 4 1 4 2 1 1
1 3 4 5 8 7 2 4 8
1
1
2 1
III II III II III III III III II III III III II III III III II III III
II + III II + III II + III III II
III III III III II II II II III III III III III II II + III III II III
PPAT PPCDC PPCS PPDPF PPFIA1 PPFIA3 PPFIBP1 PPHLN1 PPIA PPIB PPIC PPID PPIE PPIF PPIG PPIH PPIL1 PPIL2 PPIL3 PPIL4 PPIP5K1 PPIP5K2 PPL PPM1A PPM1B PPM1D PPM1F PPM1G PPM1H PPM1K PPM1L PPM1M PPME1 PPOX PPP1CA PPP1CB PPP1CC PPP1R10 PPP1R11 PPP1R12A PPP1R12B PPP1R12C PPP1R13B PPP1R13L PPP1R14B PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R2 PPP1R21
1
3 1
2
2
1
1 1 1 2 4
1 2 1 3 1 2 1 4 1 5
1 1 4
3
4 5
4
1 10
5 14
2
2
1 1 1
2 1 5
7 5 3
5
6 2
9 6
2
2 1 2
1 2 2 8 2 1
1 2 9 8 7 2 3
2 1 3 1
1 1 3 17
3 23
1
8
2 5 25 1 21 1
II + III II III
III III II II II II III II + III III III III III II III
III III III II II + III
III II II II II II + III III III III II III III III II II + III III
PPP1R26 PPP1R35 PPP1R37 PPP1R3B PPP1R3C PPP1R3F PPP1R7 PPP1R8 PPP1R9B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2D PPP2R3B PPP2R3C PPP2R4 PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PPP3CA PPP3CB PPP3CC PPP3R1 PPP4C PPP4R1 PPP4R1L PPP4R2 PPP5C PPP6C PPP6R1 PPP6R2 PPP6R3 PPRC1 PPT1 PPTC7 PPWD1 PQBP1 PQLC1 PQLC2 PQLC3 PRADC1 PRAF2 PRAME PRC1 PRCC PRCP
3 1 1
3 1
1
5 2 5 2 4
6 2 1 4 1 2 2 1
1
1
2 2 1
1 3 1 1 3
1
1 1
7 3 2 3 3 2 1 13 8 11 3 4 2 6 2
2
4 3
2 4 2 2 1
4 2 1 1 1
4 2 2
6 2 9
1 1 6 1 1 1 8 2 1
2 1 14 3 2 4 9 3 4 1
1 1
5 3
1 2
1 1 3 4 13
3 6
II + III II III III III III II II III
II III III III II II III III II III III III III III II III III II + III III II + III III II + III III III III II + III III II + III
PRDM10 PRDM15 PRDM2 PRDM4 PRDX1 PRDX2 PRDX3 PRDX4 PRDX5 PRDX6 PREB PRELID1 PREP PREPL PREX1 PRIC285 PRICKLE3 PRICKLE4 PRIM1 PRIM2 PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKAG1 PRKAG2 PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCDBP PRKCI PRKCSH PRKCZ PRKD2 PRKD3 PRKDC PRKRA PRKX PRMT1 PRMT10 PRMT2 PRMT3 PRMT5 PRMT6 PRMT7 PRNP
1 1 1 1 2
2 2 2
3 1 1
7
1 1
2 1 1
3 2 1
1
2 1 4 1 2
1 5 2 1 5
2
3 2 5 9 2 4 2 2
5 3 6 5 3 2 1
2 1
2 4 1
5
6
3
1 5
2
1 1
1 1 4 1 1 2 2
2 2 2 1
7 2 2 2
1 1
4 2 2 6
2 1
1 1 5
5
II
II III III III II III
III II II II III III III II II II III II + III II II II II II III III II II + III III II III II + III II III II + III III III III II + III III II
PROCR PROS1 PROSC PROSER1 PRPF18 PRPF19 PRPF3 PRPF31 PRPF38A PRPF38B PRPF39 PRPF4 PRPF40A PRPF4B PRPF6 PRPF8 PRPS1 PRPS2 PRPSAP1 PRPSAP2 PRR11 PRR12 PRR13 PRR14 PRR14L PRR5L PRR7 PRRC1 PRRC2A PRRC2B PRRC2C PRRG1 PRRX2 PRSS16 PRSS21 PRSS23 PRSS27 PRSS56 PRTFDC1 PRUNE PSAP PSAT1 PSD3 PSEN1 PSEN2 PSENEN PSIMCT-1 PSIP1 PSKH1 PSMA1 PSMA2
2
2
5
3
5
1 8
2 1
1 3 6
2 1 1 3 1 1 2 8
1 10 1
1 1 4 7 1
1 1 3 3 17 10 5
2 2 2 20 21 9 1
1
4 2 1 5 1 2 2 2 3 13 1 1 1 3 5 27 2 4 10 3 4 4 40 33 17 2 1
4 6
7 6
7 5
5
3
3
1 7
1 5 2 1 4 1
8 3 7 3 9 1 1
1
1 1 1
1
3
3
4 2 4
II II III III III III III III III III II III III III III III III II II III III III III II III III II II III III II II III III III II III III III III III III III III III II II
PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB10 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMB8 PSMC2 PSMC3 PSMC3IP PSMC4 PSMC5 PSMC6 PSMD1 PSMD10 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD4 PSMD5 PSMD6 PSMD7 PSMD8 PSMD9 PSME1 PSME2 PSME3 PSME4 PSMF1 PSMG1 PSMG2 PSMG3 PSMG4 PSPC1 PSPH PSRC1 PSTK PTAR1 PTBP1 PTBP2 PTBP3
1 1
1 1 1 1
1 1 2 1
1 3 2 1 5
4
1 4 1 1
2 1 4 2
1 1 2
1 1
2 2
2 1 1 2 4
2 1 1 2 3 2 2 6
1
5
3 1
1 2 2
5 4 3
1
7
11 1 2
2 1
1 1 1
1
2 3 1
1 2
6
2 6
1
2
3 11 3 8
II + III II III II II II II III III III
III II III III II II III II III III II II II + III III III II + III II II + III III II II + III
II III II III II + III III III III
PTCD2 PTCD3 PTCH1 PTDSS1 PTDSS2 PTEN PTER PTGES PTGES2 PTGES3 PTGFRN PTGR1 PTGR2 PTGS1 PTK2 PTK2B PTK7 PTMA PTMS PTOV1 PTP4A1 PTP4A2 PTPDC1 PTPLA PTPLAD1 PTPLB PTPMT1 PTPN1 PTPN11 PTPN12 PTPN13 PTPN14 PTPN18 PTPN2 PTPN21 PTPN23 PTPN3 PTPN9 PTPRA PTPRF PTPRJ PTPRK PTPRM PTPRS PTPRU PTRF PTRH1 PTRH2 PTRHD1 PTS PTTG1
1 1 1 1 3 1 2
1 2 1 4 2
1
1 6 1 3 2 2 2 2
3 1 4 6 10 9 1 4 3 4 2 1
4
5 1
1 2
2 3
6 3
2 13 9 3 4 4
2 3
4 2 1 7 4 3
3
4
6
1 4
2 5 2 1
7 4 4 5 2 6 7
1
1 1 3 1
4 4 1
6 8 6
1 4
1 3
3
2
3
2
2
16 2 4
1
1 1
II III II + III II + III II + III
III III II
II II II II + III II II + III III III II III III III II II + III II + III III III II III II III III III II + III II II + III III II + III III III III III II III
PTTG1IP PUF60 PUM1 PUM2 PURA PURB PUS1 PUS3 PUS7 PUS7L PUSL1 PVR PVRL2 PVRL3 PVT1 PWP1 PWP2 PWWP2A PWWP2B PXDC1 PXDN PXK PXMP2 PXN PYCR1 PYCR2 PYCRL PYGB PYGL PYGO1 PYGO2 PYROXD1 PYROXD2 QARS QDPR QKI QPCTL QPRT QRICH1 QRSL1 QSER1 QSOX1 QSOX2 QTRT1 QTRTD1 R3HCC1 R3HDM1 R3HDM2 R3HDM4 RAB10 RAB11A
2 3 2 1
2
2 2 1
5 1 7 6 7 6 3 1 1
6 3 4 9 8 12 10 3 1
4 2 3 5 1 1
14 4
3 2 16
2 5 17 1
5
5 2 1
2 2 1 3
1 2 10 2
9 1 5 3 9 8 19
17 5 1 1 2 4 9 14
2
1
2 1 5 3 2 7 1 23 5 16
2
5 1 1 2
4 4 2
8 1 10
2
2
4 4 2 1
1 1
1
5
III
III II III III II III III II III II III III III III III
II II
II + III
II + III III II III II III III II II II + III III II III III
RAB11B RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 RAB12 RAB13 RAB14 RAB17 RAB18 RAB1A RAB1B RAB20 RAB21 RAB22A RAB23 RAB24 RAB26 RAB27A RAB28 RAB2A RAB2B RAB30 RAB31 RAB32 RAB33B RAB34 RAB35 RAB3D RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB40B RAB40C RAB4A RAB5A RAB5B RAB5C RAB6A RAB6B RAB7A RAB7L1 RAB8A RAB8B RAB9A RABAC1 RABEP1 RABEP2 RABEPK RABGAP1
2 1
2 14 4
1
2
9
1
3 1
2 2 1
4 3 3 5 8 7 3 1 3
1
3 1
3 1 2
1 6
1
1 1 1 1 3
1 2
2 4 1 1 3 3 1
1 9 5 4 5 5
1
3
1
1 2 3 2
10 1 2 5 8 1
1
3
1
3
3
2
1 3 1
1 3
5 1 8 2 2 6 1
2 2
1
III III III II II III III III III III III III III III III II III II + III II + III III III
II II II III
II III II III III III III II
RABGAP1L RABGEF1 RABGGTA RABGGTB RABIF RABL3 RABL5 RAC1 RACGAP1 RAD1 RAD17 RAD18 RAD21 RAD23A RAD23B RAD50 RAD51 RAD51AP1 RAD51B RAD51C RAD52 RAD54B RAD54L RAD54L2 RAD9A RAE1 RAF1 RAI1 RAI14 RALA RALB RALBP1 RALGAPA1 RALGAPB RALGDS RALGPS2 RALY RAN RANBP1 RANBP10 RANBP17 RANBP2 RANBP3 RANBP6 RANBP9 RANGAP1 RANGRF RAP1A RAP1B RAP1GAP RAP1GAP2
1
1 1
2
1 3 1
3 1 3
5 2 1
1 2
5 3
1
7 5
2 1 1
1 1 3 8
1 1 3
1
2 3 12 2
1 2 6 4 5 8 32 3
1 2 1 1 2 2 5
1 2 1 4 3 1 2 4
1 1
4
1 1 8
2
2 2
10 1
1 5
12 2 6 4 2 2 18 1 1
13
III II + III II II
II + III III III III
III II + III III III III II III II + III II II II + III III II III III III III III II III
II II + III II + III II II + III II + III III III III
RAP1GDS1 RAP2A RAP2B RAP2C RAPGEF1 RAPGEF2 RAPGEF6 RAPH1 RARA RARG RARS RARS2 RASA1 RASA2 RASA3 RASAL2 RASGEF1B RASIP1 RASL10B RASL11A RASSF1 RASSF3 RASSF7 RASSF8 RAVER1 RAVER2 RB1 RB1CC1 RBAK RBBP4 RBBP5 RBBP6 RBBP7 RBBP8 RBBP9 RBCK1 RBFA RBFOX2 RBKS RBL1 RBL2 RBM10 RBM12 RBM12B RBM14 RBM15 RBM15B RBM17 RBM18 RBM19 RBM22
1 1 1 1
1
2 3 3 1 2 5 6
1
5 5 4 6 2 6 14 11 1 2
1 3 2 2
5 2 2
8 1 3 5
1
3 4
1 1
4 2
4 2
1 1
2 4 3 2
2
6 1 2 1 1
9 8 2 3 4 6 3 1 10
2
1 2 2 5 5 5
1 3 2
2
8
2
2 1 1 15 9 11 19 17
2 7 3 3 15 9 1
1 2
3 5
II III II III II II II III II + III II III III
III III III III II III III III III II II + III III III II III III II II II II + III III II III II II III
RBM23 RBM25 RBM26 RBM27 RBM28 RBM3 RBM33 RBM34 RBM38 RBM39 RBM41 RBM42 RBM45 RBM47 RBM48 RBM4B RBM5 RBM6 RBM7 RBM8A RBMS1 RBMX RBMX2 RBPJ RBPMS RBPMS2 RBX1 RC3H1 RC3H2 RCAN1 RCAN3 RCBTB1 RCC1 RCC2 RCCD1 RCE1 RCHY1 RCL1 RCN1 RCN2 RCN3 RCOR1 RCOR2 RCOR3 RDBP RDH10 RDH11 RDH13 RDX RECK RECQL
1
1 2 1
4 1 1 7 2 2 2
6 2
7 7
1
1
5 3 1 8 2 7 5 5 14 3 1 1
1
2 1 3 1 3
2
2 2 4
1
3 1 1
4 7 2
2 2 1
10 4 5
3 2 2
7 13 2 2
3 1 3 4
2 2 1 2 6
2 4 1 3 8
2
2
6 1
2 5
1 4 4 1
4 10 7 1
1 1 1
1 1
III III III III II II III III III III III II + III III II II II + III II
II III III III III III III III III II II
II + III III II III III III III II + III II III III III III
RECQL4 RECQL5 REEP1 REEP2 REEP3 REEP4 REEP5 REEP6 REL RELA RELB RELL2 RELT REPIN1 REPS1 RER1 RERE REST RETSAT REV1 REV3L REXO1 REXO2 REXO4 RFC1 RFC2 RFC3 RFC4 RFC5 RFK RFNG RFT1 RFTN1 RFWD2 RFWD3 RFX1 RFX5 RFX7 RFXANK RFXAP RGL2 RGL3 RGMB RGNEF RGP1 RGS10 RGS12 RGS14 RGS19 RGS2 RHBDD2
1
1 7 2
1 6 4
5 4
1 1
3 5
5
4
4 1 7 1
4 4 4 1 2 2 4
1 1
1 1 1 1 4 1
1 1
1 1 16 1 3 7 6 2 1 6 13 1 2
1
2
1
2
3 1
3 4
7 1 1 3
1 8 2 2 4 1
1 2 2 3
3 2 2
5 4 3 4 1
1 2
3
III III II III III II + III II + III III III II + III III III II + III II + III III III II II + III II + III III III III II + III II III III II III III III II + III
II + III III II + III
III III II
RHBDD3 RHBDF1 RHBDF2 RHEB RHOA RHOB RHOBTB1 RHOBTB2 RHOBTB3 RHOC RHOD RHOF RHOG RHOT1 RHOT2 RHOU RHOV RHPN1 RHPN2 RIBC2 RIC8A RIC8B RICTOR RIF1 RILP RILPL1 RILPL2 RIMKLB RIMS4 RIN1 RIN2 RING1 RINT1 RIOK1 RIOK2 RIOK3 RIPK1 RIPK2 RIPK4 RIT1 RLF RLIM RLTPR RMI1 RMI2 RMND1 RMND5A RMND5B RMRP RNASEH1 RNASEH2A
2
2
3 15
13
3
5
5 1 1 1 9 1
2 1 5 1 3 10 7 20 5 1 1 23 7
1 6
2 7 1
2 5
1 3 2 2 2
1 4 8 2 1 2 5 5 5 3
1
4
2 2
5 5
1 1 1
1
1
1 2
1 8 1 1
1
1 4 3
2
2
4
1
2
1
1 1 1
1 1 1
2 1 1
2
8 11 1
1 1
3 3
III II II III II II + III II III II III III
III II + III III II + III III
III
III II II + III III
III II II II + III III III II + III II + III III II + III III
RNASEH2B RNASEH2C RNASEK RNASEL RNASET2 RND3 RNF10 RNF11 RNF111 RNF113A RNF114 RNF115 RNF121 RNF123 RNF126 RNF13 RNF130 RNF135 RNF138 RNF139 RNF14 RNF141 RNF144B RNF145 RNF146 RNF149 RNF150 RNF166 RNF167 RNF168 RNF169 RNF170 RNF181 RNF182 RNF185 RNF187 RNF19A RNF19B RNF2 RNF20 RNF212 RNF213 RNF214 RNF215 RNF216 RNF216P1 RNF217 RNF219 RNF220 RNF24 RNF25
1 6
4 5
2
2
1
3
1
1
2
4
2
1 1
2 2
4
5
4
2 1 4
1 2 6
5 1 4 1 1 9 1 3 3 1
1
1 1 5
1 2 6
2 4 4 6 1 1 1 2 2 10 1
2 1
1 8 3 1
1 1 1
2
3 5 1 1 1 3 6 10 1 1 10 13 5 4 1 3 2 13 1 9 19 5 1 5 1
II + III III II + III II + III II III III III II II II III III II II III II III III II + III III III III III II III III III III III III III III II III III III II II III II
RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF41 RNF44 RNF6 RNF7 RNF8 RNFT1 RNFT2 RNGTT RNH1 RNMT RNMTL1 RNPC3 RNPEP RNPEPL1 RNPS1 ROBO1 ROCK1 ROCK2 ROGDI ROMO1 ROR2 RP2 RP9 RPA1 RPA2 RPA3 RPAIN RPAP1 RPAP2 RPAP3 RPE RPF1 RPF2 RPGR RPGRIP1L RPIA RPL10 RPL10A RPL11 RPL12 RPL13 RPL13A RPL13P5 RPL14 RPL15
11
22
27
2
3
5
1 1
1 6 4
4 11 6 4 4 1 2 1 8 8 2 2 4
2 1
2
5
1 1
2 1 2 1
2 1
3 3 1 3 5
10 4 2 1 7
10
2 15 2
2
5 1 1 1
1
2
1 1
1
1
1 5 2 1 1
2 2
3 3 1
2 2 1
3 3
3 1
3
2 1
1 4
III II III III III III III III III III III III II II III II III III II III II III II III III II II III II II III II III II II III II III II II + III II + III II III III II + III II + III III III
RPL17 RPL18 RPL18A RPL19 RPL22 RPL22L1 RPL23 RPL23A RPL24 RPL26 RPL26L1 RPL27 RPL27A RPL28 RPL29 RPL3 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36AL RPL37 RPL37A RPL38 RPL39L RPL4 RPL41 RPL5 RPL6 RPL7A RPL8 RPL9 RPLP0 RPLP1 RPLP2 RPN1 RPN2 RPP14 RPP25 RPP25L RPP30 RPP38 RPP40 RPRD1A RPRD1B RPRD2 RPS11 RPS12
1
1 1
1 5
2 2
2 2
3 2
2 2 1 1
2 2
2 5 1 1 2 1
1
1
9 4 2 2 3 3 3
1
3
1
1
1
1
1 3
2 1 1
1 2 1
1 2 1 3 1 5 3 1 3
3 6
1
3 1 1 1 2 2 3 1 9 3 1
2 7 1
5 9 1 6 1 1 2 7 16 1 2
7 3 2 3 6 4 1 4 9 6 16 3 1 2 3 12 30
III III III II III III III III III II II III III III III III III III III II II III
III II + III III II III III II II II + III III
II + III
III III II II + III II
III II
RPS13 RPS14 RPS15 RPS15A RPS16 RPS18 RPS19 RPS19BP1 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27A RPS27L RPS28 RPS29 RPS3 RPS4X RPS5 RPS6 RPS6KA1 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KB1 RPS6KB2 RPS6KC1 RPS7 RPS8 RPS9 RPTOR RPUSD1 RPUSD2 RPUSD3 RPUSD4 RQCD1 RRAGA RRAGB RRAGC RRAS RRAS2 RRBP1 RREB1 RRM1 RRM2 RRM2B RRN3 RRNAD1 RRP1
1 1 1
1 1 1 1 1
1 1 1 1
2 1 1 1 3
1 1 1
1 1 2 2 4 3 1 1
2
3 2 3 2
3 2 2 1 3
2 1
1 1 3 4 2 3 2 2
2
8
2 2 1 1 8 2 1
1 1 3
2 4 2 4
2 3
22 15 4 3 2 3 3 1 1
1 5 3
1
1 7 1 5 1 1 1 2
3 20 1 3 1 1 3 3
II III II + III II II III III III
II + III II II III
III III III III III
III II II II + III II III III III II + III III II + III II III III
II
III III II III
RRP12 RRP15 RRP1B RRP36 RRP7A RRP7B RRP8 RRP9 RRS1 RSAD1 RSBN1 RSBN1L RSF1 RSG1 RSL1D1 RSL24D1 RSPH3 RSPRY1 RSRC1 RSRC2 RSU1 RTCA RTF1 RTKN RTKN2 RTN2 RTN3 RTN4 RTN4IP1 RTN4R RTN4RL2 RTTN RUFY1 RUFY2 RUFY3 RUNDC1 RUSC1 RUSC2 RUVBL1 RUVBL2 RWDD1 RWDD2A RWDD2B RWDD3 RXRA RXRB RYBP RYK S100A10 S100A11 S100A13
1
2
2 2 2 1
1 1 3 1
1 1 1 1 1 2
1 4 3
1 1 3 4 6 2 1 1 4 1 1 8 2 5
1 1
3
2 5 1
2 6
7 8
2 9
3 3
5 3
5 9
1
1
3 4 3 6 1 1
1 2 5 12 4 1
1
1
6 3 3
25 6 6 2 2 5 1
2 1 1
7
2
2 4
III III II III III
III III III II + III III III III III III II + III II III III III III II II II II III II III III II III III III
III III III
II II
S100A16 S100A2 S100A4 S100A6 S100P S100PBP S1PR5 SAA1 SAAL1 SAC3D1 SACM1L SACS SAE1 SAFB SAFB2 SAMD1 SAMD10 SAMD11 SAMD4A SAMD4B SAMD8 SAMHD1 SAMM50 SAP130 SAP18 SAP30 SAP30BP SAP30L SAPCD2 SAR1A SAR1B SARNP SARS SARS2 SART1 SART3 SASH1 SASS6 SAT1 SAT2 SATB2 SAV1 SAYSD1 SBDS SBDSP1 SBF1 SBF2 SBNO1 SBNO2 SC5DL SCAF1
1
1
2
2
3 1
1 1
3
1 2 3 2
1 1
2 2 3
1
1 1 2 1
2 5 1 2 1 1 2 1 4 2 3
2
4 1
1
1 1 1 1 1 1
1 3 6 8
1 2 15
1 3 5 7 1
3 1 1 8 2 12 4 3 1 3 1 1 5 1 1 2 6 3 3 1 1 5 2 4 4 27
II + III III III II II III III II III II + III II II III II III III III III
III II + III III III III III III III III II II + III II II + III
II III II III II II II
III
SCAF11 SCAF4 SCAF8 SCAI SCAMP1 SCAMP2 SCAMP3 SCAMP4 SCAMP5 SCAND1 SCAP SCAPER SCARA3 SCARB1 SCARB2 SCCPDH SCD SCD5 SCFD1 SCFD2 SCLT1 SCMH1 SCML1 SCML2 SCN1B SCO1 SCOC SCP2 SCPEP1 SCRIB SCRN1 SCRN2 SCRN3 SCYL1 SCYL2 SCYL3 SDAD1 SDC1 SDC2 SDC3 SDC4 SDCBP SDCCAG3 SDCCAG8 SDF2 SDF2L1 SDF4 SDHA SDHAF1 SDHAF2 SDHAP1
1 2 5
2 2 7 1 1 1 2 7
2 4
3
13 10 1
21 12 1
4 11 1 1 5 3 33 13 6
16
24 1
26 4
1
1 4 1 4
1
2
2
1
5 4 11 1
1 2 2
1 1 1 12
4 2 1 2 4 3
1
1 1 1 1 13
3 4 1 1 18
1 4 2 5
2 5 3 7
4 1 9 3
9 2 5 10 1 1
II III III II III III III III III II III III II + III III III III II + III II II II + III III III III III III III II + III III II + III III III III III II + III III II III II + III
II
SDHAP2 SDHAP3 SDHB SDHC SDHD SDR39U1 SEC11A SEC11C SEC13 SEC14L1 SEC14L2 SEC14L4 SEC16A SEC22A SEC22B SEC22C SEC23A SEC23B SEC23IP SEC24A SEC24B SEC24C SEC24D SEC31A SEC61A1 SEC61A2 SEC61B SEC61G SEC62 SEC63 SECISBP2 SECISBP2L SECTM1 SEH1L SEL1L SEL1L3 SELENBP1 SELK SELM SELO SELRC1 SELT SEMA3B SEMA3C SEMA3F SEMA4B SEMA4C SEMA4D SEMA6D SENP1 SENP2
1
1
1
1 3 1
2 2 1 3
1
1
11
1 1
5 5
13 1 2 3
24 1 3 3 1 1 4 5 2 4 1 2 26 3
1
1 1 2 1 18
2 5 4 1 26 2
1
1
1
3 1 1 6 2
4
2 1 4
2
1
1
1 3 2
1 1 1
3
4 2 2 4 4 2 8 3 1 4 1 7 2 2 1 5 2 2 3 6 5
III III
II II + III II
III III III III
II II III III III III II III III II II + III II II III II + III II + III II + III
II
II II II + III II + III II + III III II
III III
SENP5 SENP6 SENP7 SENP8 15-Sep SEPHS1 SEPHS2 SEPN1 SEPSECS 10-Sep 11-Sep 2-Sep 3-Sep 6-Sep 7-Sep 8-Sep 9-Sep SEPW1 SERAC1 SERBP1 SERF2 SERGEF SERINC1 SERINC2 SERINC3 SERP1 SERPINB1 SERPINB6 SERPINE1 SERPINE2 SERPINH1 SERPINI1 SERTAD1 SERTAD2 SERTAD3 SERTAD4 SESN1 SESN2 SESN3 SESTD1 SET SETD1A SETD1B SETD2 SETD3 SETD4 SETD5 SETD6 SETD7 SETD8 SETD9
1
1 1 1
2 3 3 6
4 1 1 3 1 7 6 1 1 3
2
1
6 3
2 1
5 2
2 1 1 1 10 4 8
1 7
1 2 5 1
1 5 3 2
2 17 2 6
3 10 1 8
3 4 4
1 4 6
3 14 7 3
1
1
6 1
3 1 10 3 1
6 3 16 6 1
9 1
21
7 9 30 11 2 1 41 1 11 2
5 2
9 3
II
II + III III II III III II III II II II III
II III III III II + III III III III II III III III II II + III II + III II + III II + III III III II + III II + III III III II III III III III II III
SETDB1 SETDB2 SETMAR SETX SEZ6L2 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B14 SF3B2 SF3B3 SF3B4 SF3B5 SFI1 SFMBT1 SFMBT2 SFN SFPQ SFR1 SFSWAP SFT2D1 SFT2D2 SFT2D3 SFXN1 SFXN2 SFXN3 SFXN4 SFXN5 SGCB SGCE SGK1 SGK196 SGK223 SGMS1 SGMS2 SGOL1 SGOL2 SGPL1 SGPP1 SGSH SGSM2 SGSM3 SGTA SGTB SH2B1 SH2D2A SH2D3A SH2D4A SH3BGRL
1
5 5
2 1 2 3 2 2
7 1 7 1 8 1 2 4
7 3 5 11 1 15 3 2 5 4
4 12 5
6 12 7 3
4
6 5 3 4
3
3 1
1
1 1
1 1 1 3
1
1
2 9
1 3 19 1
1 1 1 1 15 11 15 10 3 2 2 1 7 23 2
3
4
4
1 9 8 4 2 1
8 8 7 6 2 1
1 1
1
5
II III II + III II III III III III III II + III II + III
II + III III II III III III III III III II II + III
II II + III II + III II + III III III II II + III II + III II II II + III II II + III II + III
SH3BGRL2 SH3BGRL3 SH3BP2 SH3BP4 SH3BP5 SH3BP5L SH3D19 SH3GL1 SH3GL2 SH3GLB1 SH3GLB2 SH3KBP1 SH3PXD2A SH3PXD2B SH3RF1 SH3RF2 SH3TC1 SHARPIN SHB SHC1 SHCBP1 SHFM1 SHISA4 SHISA5 SHKBP1 SHMT1 SHMT2 SHOC2 SHPK SHPRH SHQ1 SHROOM1 SHROOM3 SIAE SIAH1 SIAH2 SIDT2 SIGIRR SIGMAR1 SIK1 SIK2 SIK3 SIKE1 SIL1 SIM2 SIN3A SIN3B SIPA1 SIPA1L1 SIPA1L2 SIPA1L3
1 3 3 1
1 6 1 1 1 2
2 8 16 3 8 2 2
1
1 3
4 5
5 6
2
4 1 2 10 1
19 13 4 1 16 2 4 17 1
3
1 5
3
1 2
2 3 2 1 1
1 10 3 4 1 1 1 2 1 1 1 2
3 1 1
3 4 8
1 2 2
1 4 9
1 3 1
8 4 3
9 4
4 17 8 7 1 2 5 12 3 2 3 2 10
2 1 2 7 1 1 1 3
III
III III III II II + III II + III III III III III II II + III III III III II III II + III II + III
II + III II II + III II + III
II II + III
III III II
II + III II + III II II III II + III
SIRT1 SIRT2 SIRT3 SIRT4 SIRT5 SIRT6 SIRT7 SIVA1 SIX1 SIX2 SIX4 SIX5 SKA1 SKA2 SKA3 SKAP2 SKI SKIL SKIV2L SKIV2L2 SKP1 SKP2 SLAIN2 SLBP SLC10A3 SLC11A2 SLC12A2 SLC12A6 SLC12A7 SLC12A9 SLC15A4 SLC16A1 SLC16A10 SLC16A13 SLC16A3 SLC16A5 SLC16A7 SLC16A9 SLC17A5 SLC18B1 SLC19A1 SLC19A2 SLC1A1 SLC1A3 SLC1A4 SLC1A5 SLC20A1 SLC20A2 SLC22A18 SLC22A23 SLC22A4
1
1 4 1
5 3 1
1 1 1
2
1
2
1 5 6 5
4 11 13 6 4
1
2
9 3
16 8
2
1
13 5 3 7
21 3 5 11
1 2 5 20 5 4 1 29 4 4 18
18 1
18 2
3 26 7
1
5
9 1 1 4 6 18 3 4
6 2 1 3 10 19 6 3 2 6 3
1 5 1
2
6 5 10 2 3
1 1 16 2 1
4 1
II II III III II III III III II
II III II III II + III II + III II
III II + III II + III II III III III II + III
II II II + III III III II III II III II III II + III
SLC22A5 SLC23A2 SLC24A6 SLC25A1 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A28 SLC25A29 SLC25A3 SLC25A30 SLC25A32 SLC25A33 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A4 SLC25A40 SLC25A42 SLC25A43 SLC25A44 SLC25A46 SLC25A5 SLC25A6 SLC26A11 SLC26A2 SLC26A6 SLC27A1 SLC27A2 SLC27A4 SLC27A5 SLC29A1 SLC29A2 SLC2A1 SLC2A11 SLC2A13 SLC2A3
2 1
2
2 4 3 1 1 4
1
1
2
2 2
2 3
1 2
2
2 4 2 5
1 2 1
1
1 3 1
1 4
3 5 3
2 10 3 1
10 19 3 2 2
1 3 1 3 1
5 5 1
9 9 3 2
3 6 1 2 8
1 3 11 2 3 10
1
2 8 1 3 1 1
8
4
9
11 1 2 2 9
1 10
8 3 13
8 8 12
3
7
8
II II + III III II + III II
III II II + III II + III
II II + III III II II + III II + III II
II + III II + III II II II III II + III III II II II + III III II III II II + III II + III III II + III II II II III II + III
SLC2A4RG SLC2A6 SLC2A8 SLC30A1 SLC30A5 SLC30A6 SLC30A7 SLC30A9 SLC31A1 SLC31A2 SLC33A1 SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35E1 SLC35E3 SLC35E4 SLC35F2 SLC35F5 SLC35G1 SLC36A1 SLC36A4 SLC37A1 SLC37A3 SLC37A4 SLC38A1 SLC38A10 SLC38A2 SLC38A6 SLC38A7 SLC38A9 SLC39A1 SLC39A10 SLC39A11 SLC39A13 SLC39A14 SLC39A3 SLC39A6 SLC39A7 SLC39A8 SLC39A9
1 3 1 3 1
1 2 6
5 2 2 10 3 5 1 2 5 4 8
5
14
3
10 2 1 7
3 3 4
1 8 6
21 2 2 15 1 8 11 15
1 6 1
16 1
31 3
3 1
5 1
1
3
5 2 1 4
1 1 1 2
6 1
2 2 3 2 3 1
8 5 7
1 2 2 16 7 10
2
4
7 1 1 2 7 2 2 8
10 4 3 1 22 3 8 12
5
4
1
3 7 5 30 18 20 2 8 13 5 4 23 5 9 14 1 10
II II III III II III II + III III II III II III II II II II II II + III II + III II + III II II + III III III
III
II II
III III III III III III III
II + III II + III
SLC3A2 SLC41A1 SLC41A2 SLC41A3 SLC43A1 SLC43A2 SLC44A1 SLC44A2 SLC45A3 SLC45A4 SLC47A1 SLC48A1 SLC4A1AP SLC4A2 SLC4A7 SLC50A1 SLC52A2 SLC5A3 SLC5A6 SLC6A15 SLC6A6 SLC6A8 SLC6A9 SLC7A1 SLC7A11 SLC7A2 SLC7A5 SLC7A6 SLC7A6OS SLC9A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLC9A6 SLC9A8 SLCO3A1 SLCO4A1 SLFN12 SLFN5 SLIRP SLK SLMAP SLMO1 SLMO2 SLPI SLTM SLU7 SLX4 SMAD1 SMAD2 SMAD3
10 4
17 5
2
3
8 1
6
8
3
3 4 6 1 5 2 5 2 1 6 7 7
1 3
1
1
1
3
7 2
6 2 1
3
4 2 3 11 1 1 46 5
3 2 10 4 10 28 3 3 50 5 2 2
11 8
5 21 10 1 1
1 1 4 1
1 1 6
2 7
13 13 2
12 10 9 48 5 6 43 14 2 9 4 2 3 6 19 21 2 2 2 2 2 3 4 1
3 5 5 17
II + III II + III II + III II + III
III III III
III III III II III III III II III III III III III
II + III II + III II + III II + III II II II + III III II II III II + III III II III III III III II + III
SMAD4 SMAD5 SMAD6 SMAD7 SMAGP SMAP1 SMAP2 SMARCA1 SMARCA2 SMARCA4 SMARCA5 SMARCAD1 SMARCAL1 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMC1A SMC2 SMC3 SMC4 SMC5 SMC6 SMCHD1 SMCR7 SMCR7L SMCR8 SMEK1 SMEK2 SMG1 SMG5 SMG6 SMG7 SMG8 SMG9 SMNDC1 SMOC1 SMOX SMPD1 SMPD2 SMPD4 SMPDL3A SMS SMTN SMU1 SMUG1 SMURF1 SMURF2
1 2 5 1
3 10 7 4 2 1
9 15 13 5 3 1 2
2 1
3 2 2 1
1 2
1 4 1 3
4
1 7 3 5
1 4
8 3 1
1 14 2 2 1 1 1
1 2 12 39 7 6 5 14 9 15 10
3
4 3 19 4 2 1 5 3 3 6 1 1 7 1 7
1
2
8
4 15 3 2 1 4 3 1 1
1 1 1 1
1 4 7
1 1 1 5
1 6 3
III III II III III III III II + III III II III II III II III III II III III III III III III III
II III III III III II III III III III II III III III III II III III
III
SMYD2 SMYD3 SMYD4 SMYD5 SNAI1 SNAP23 SNAP25 SNAP29 SNAP47 SNAPC1 SNAPC2 SNAPC3 SNAPC4 SNAPC5 SNAPIN SND1 SNF8 SNHG1 SNHG10 SNHG11 SNHG12 SNHG15 SNHG5 SNHG6 SNHG8 SNHG9 SNIP1 SNRK SNRNP200 SNRNP25 SNRNP27 SNRNP35 SNRNP40 SNRNP48 SNRNP70 SNRPA SNRPA1 SNRPB SNRPB2 SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SNTA1 SNTB1 SNTB2 SNUPN SNW1
1 1 1
5 2
8 5
4 1
2 1 1
5
1
7 2 2 2 9 2
1
2
1
1 2 1
5 1 4 1 1 1
1 2 4
3
1
1
2 1 1 2 4 3 2 1 1 1 1 1 1 1 1
4 6 3 2 1 1 1 6 3 1 4 1 2 1 2 1 1 1
2
6
III III III II II + III III III II + III II
II III II + III III III III II II II II + III II + III II + III III III III II II II + III III II III III II II + III II II II + III II + III III III II + III III
SNX1 SNX10 SNX11 SNX12 SNX13 SNX14 SNX17 SNX18 SNX19 SNX2 SNX21 SNX24 SNX25 SNX27 SNX3 SNX30 SNX33 SNX4 SNX5 SNX6 SNX8 SNX9 SOAT1 SOCS2 SOCS3 SOCS4 SOCS6 SOCS7 SOD1 SOD2 SOGA1 SOGA2 SOLH SON SORBS2 SORBS3 SORD SORT1 SOS1 SOS2 SOWAHC SOX12 SOX13 SOX4 SOX9 SP1 SP100 SP2 SP3 SP4 SPA17
1
1 1
6 2 1
2 4 1
3 1 1
1
4
2
2 4
3 4 4 2 1 3 10 1 5
7 1 1 17
3 1 1 1 4 3 16 3 1 1
1
27 2 1 18
39 12 10 36
5 3 1 9
1 1 1 2 2 5 8 2 12
3
10
2 2 3 7 2 13 15 6 24 1 18
4
2 2 2
5 8 3
4 1 2 1 7 2
1 10 4 15 1
2
6 3 6 7 25 9 5 1 1
III III II III
II + III III II + III III III
III III II III III II + III II II + III III II II II II + III
III III III II + III II II + III III II + III III III III
SPAG1 SPAG4 SPAG5 SPAG7 SPAG9 SPAST SPATA13 SPATA17 SPATA2 SPATA20 SPATA24 SPATA2L SPATA5 SPATA5L1 SPATA7 SPATS2 SPATS2L SPC24 SPC25 SPCS1 SPCS2 SPCS3 SPECC1 SPECC1L SPEN SPG11 SPG20 SPG21 SPG7 SPHK1 SPHK2 SPICE1 SPIN1 SPIN2B SPIN3 SPIN4 SPINK4 SPIRE1 SPIRE2 SPNS1 SPOP SPPL2A SPPL2B SPPL3 SPR SPRED1 SPRED2 SPRY2 SPRYD3 SPRYD4 SPRYD7
1
4
6
2
5 1 5
2
2
1
7 1
18
1
1 1
1 1 2
1 4 1
1
2
1
10 1 1
1 1 1 10 11 24 3 4
7 1 3
4
1 2 2
4 3 1
6 1 2
5
7
13
1
2 2
1
4 2 1 1 1 2
1 3 2
5
11 2 1
2 7 1 6 1 6 5 3 3 21 2 3
II + III III II II + III III III II + III III II II II II III III II II II III III
II + III III III III III III II III III II II II III
II II III II III II II
SPSB1 SPSB2 SPSB3 SPTAN1 SPTBN1 SPTBN2 SPTLC1 SPTLC2 SPTSSA SPTY2D1 SQLE SQRDL SQSTM1 SRA1 SRBD1 SRC SRCAP SRD5A1 SRD5A3 SREBF1 SREBF2 SREK1 SREK1IP1 SRF SRFBP1 SRGAP1 SRGAP2 SRGN SRI SRM SRP14 SRP19 SRP54 SRP68 SRP72 SRP9 SRPK1 SRPK2 SRPR SRPRB SRPX SRR SRRD SRRM1 SRRM2 SRRM3 SRRT SRSF1 SRSF10 SRSF11 SRSF2
4
3
1 6
3 5
14 3 1 3 7
1
4
1
2
4 5
9 2
9 4
1 17
1 35
5 2 1
4 1 1
6 5 1
2
4 1 6 3
3 2 4 14
1 1 1 2
1 7 1 2 1 4 3 2 8
7 1
7 2
1 1 1
2 1 2 1
21 8 3 6 74 2
1 22
4 36 2
1
2
2 2
2 6
2 4 41 2 4 6 1 1 7
II III II III III III II + III II III III III III III II II + III III II II II III II II III III III II + III III II II III III III III
III III II III III III III II III
SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SRSF9 SRXN1 SS18 SS18L1 SS18L2 SSB SSBP1 SSBP3 SSBP4 SSFA2 SSH1 SSH2 SSH3 SSNA1 SSR1 SSR2 SSR3 SSR4 SSRP1 SSSCA1 SSU72 SSX2IP ST3GAL2 ST3GAL3 ST3GAL4 ST5 ST6GAL1 ST6GALNAC4 ST6GALNAC6 ST7 ST7L STAC STAG1 STAG2 STAG3L2 STAG3L4 STAM STAM2 STAMBP STAMBPL1 STARD10 STARD13 STARD3 STARD3NL STARD4
1
1
1 1
4
1 4 2
10 5
2 4 7 3 2 2 16 5 5 1
1
1 2 1 3 1 2 2
7
2 2
1
1 1 2 6 2 1 9 7 3 2 4 2 2 11 1 1 1 3 2 3 1 1
2
2 1 1
1 3 5 17 13 2 1 8 7 3 3 4 1 4 2 19 1 3 6 12 3 2 1 2 3 3 4 2 1
1
2 1
1 2 2 1
II + III III III III III II + III III III II II II + III III II III
II III III II III III II + III
III II III III III II III
II III III II III II II III
STARD7 STARD8 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 STAU1 STAU2 STC1 STC2 STEAP3 STIL STIM1 STIM2 STIP1 STK10 STK11IP STK16 STK17A STK17B STK19 STK24 STK25 STK3 STK32B STK32C STK35 STK36 STK38 STK38L STK39 STK4 STK40 STMN1 STMN3 STOM STOML2 STON2 STOX2 STRA13 STRADA STRAP STRBP STRN STRN3 STRN4 STT3A STT3B STUB1
1
5
9
2
3 1 1
3 3 10 1 27 4 2 3 4 2 1
4 4 9 1 1 34 5 2 4 10 4 3
1
1 1
1 1 3
2
1
3
10 1 2
1
1 1 3
1 2 1 4
5 1 3
13 3 3 1
1
3 1 3
4 5 4
6 1
5 2 3
8
1
1 3
1 5
1 1 3 4
2 1 2 4
6 3 6 3 5 1 2 2 6 3
III III II III III III III III III II + III III III II III III
III II III II III III III II III II + III III
III III III II II III II III III III II III III III II
STX10 STX12 STX16 STX17 STX18 STX1A STX2 STX3 STX4 STX5 STX6 STX7 STX8 STXBP1 STXBP2 STXBP3 STXBP4 STXBP5 STXBP6 STYX STYXL1 SUB1 SUCLA2 SUCLG1 SUCLG2 SUDS3 SUFU SUGP1 SUGP2 SUGT1 SUGT1P1 SULF2 SULT1A1 SUMF1 SUMF2 SUMO1 SUMO2 SUMO3 SUN1 SUN2 SUOX SUPT16H SUPT3H SUPT4H1 SUPT5H SUPT6H SUPT7L SUPV3L1 SURF1 SURF2 SURF4
1 2
1
6 3
2
3
2
8
1
3
4
1 1 1
2 1 2 2
1 1 1 5
1
1
4 3 1 3 1 3
2
7
10
1 1 2
4
1
2 1 2 1 1 1
1 5 5 1 3 5
1
2 1 3
3 1 4 2 1
8
19
17
1 3
II
II
III
III III III III III III II + III II + III III II II III II
II + III II II + III III
II III II + III
II II III III III II + III III III
SURF6 SUSD1 SUV39H1 SUV39H2 SUV420H1 SUV420H2 SUZ12 SUZ12P1 SV2B SVEP1 SVIL SVIP SVOPL SWAP70 SWI5 SWSAP1 SYAP1 SYBU SYCE2 SYDE1 SYDE2 SYF2 SYMPK SYNCRIP SYNGR1 SYNGR2 SYNGR3 SYNJ1 SYNJ2 SYNM SYNPO SYNRG SYPL1 SYT12 SYT17 SYVN1 SZT2 TAB1 TAB2 TAB3 TACC1 TACC2 TACC3 TACO1 TADA1 TADA2A TADA2B TADA3 TAF1 TAF10 TAF11
4
1
6
2 1 1 1 1
1 1 2
9 1 6 3 2 1 2 1 1 1 1
3
5
8 1
8 2
17 2
2 1
4 2
5 4
2 1 2 1 1
3
6 1 3 8 4 7 10
1 2
2 1 1 5
2 1
2 1
2 1 2 1 4 4 6
5 2 1 3 2
4 1
1 1
4 1 8 5 4 16 2 4 3 6
15 4 5 1
III III III III II + III III III II
II + III III II + III III III II II III II + III II + III II III III II II II II + III III II II
III II + III III III II III II II II + III III
TAF12 TAF13 TAF15 TAF1A TAF1B TAF1C TAF1D TAF2 TAF3 TAF4 TAF4B TAF5 TAF5L TAF6 TAF6L TAF7 TAF8 TAF9 TAF9B TAGLN2 TALDO1 TAMM41 TANC1 TANC2 TANK TAOK1 TAOK2 TAOK3 TAP1 TAP2 TAPBP TAPT1 TARBP1 TARBP2 TARDBP TARS TARS2 TARSL2 TASP1 TATDN1 TATDN2 TATDN3 TAX1BP1 TAZ TBC1D1 TBC1D10A TBC1D10B TBC1D12 TBC1D13 TBC1D14 TBC1D15
4 1 1 4
6 1
14 3
3
4 1
1 9 2
4
7
1
1 3
3 1 1 1 2 1 1
2 2 6 2
5 1 3
18 1 3 7 4 5 2 10 2 2 1 19 1 9 1 1 2 5 11 4
1 3 6 1
1 5 10 4
1 2
1 1 1 2
4 3 2 3 1
5
11
2 1
1
22 1 3 3
3
6
3 5
2 8
1 16 1 8 18
II + III III III
III
II + III II II + III III III II + III II + III III III II + III III III
III III II + III II III II III III II II II + III III III II III III III III III III II II + III
TBC1D16 TBC1D17 TBC1D19 TBC1D2 TBC1D20 TBC1D22A TBC1D22B TBC1D23 TBC1D24 TBC1D25 TBC1D2B TBC1D30 TBC1D4 TBC1D5 TBC1D7 TBC1D8 TBC1D9 TBC1D9B TBCA TBCB TBCC TBCCD1 TBCD TBCE TBCEL TBCK TBK1 TBKBP1 TBL1X TBL1XR1 TBL2 TBL3 TBP TBPL1 TBRG1 TBRG4 TBX1 TBX3 TBXA2R TCEA1 TCEA2 TCEA3 TCEAL1 TCEAL4 TCEAL8 TCEANC2 TCEB1 TCEB2 TCEB3 TCERG1 TCF12
2
2
1
1
5 1 1 1 3
4 2 1 2 1 1
1 2 12 8 4 2 2 1
2 6
1 2
1 2 11
2 1
3
1 2 2 1
1
1 3 2 1 2 2
2
1
1 12 5 5 2 1
1 2 2
1 1 1 6
6 3 1 10
1
1
1 4
3 1 3
1 3 2
1 2
2 1
2 4 2
1 4 6 5
II + III II + III III II III II III III III III III III III
III III
III II + III III III II III
II II III
III III II II + III II + III II + III II II III III III III
TCF19 TCF20 TCF25 TCF3 TCF4 TCF7L2 TCFL5 TCHP TCIRG1 TCOF1 TCP1 TCP11L1 TCTA TCTN1 TCTN2 TCTN3 TDG TDP1 TDP2 TDRD3 TDRD7 TDRD9 TDRKH TEAD1 TEAD2 TEAD3 TEAD4 TECPR1 TECR TEF TEFM TEKT4P2 TELO2 TENC1 TEP1 TERF2 TERF2IP TES TESC TESK1 TET3 TEX10 TEX2 TEX261 TEX264 TEX30 TFAM TFAP2A TFAP2C TFAP4 TFB1M
5 2 1
1
2 3 1 3 2 1
3 2
1 1 1 2
10 15 11 4 1 5 2 3 6
4 3 3 1 1
3
1 2
1 1
9 1 1 1
17 5 1 2
1 1
1
6 1 1 1
1 1 2 3 1 5 2 3
10 1 1 8 2
2 8 3 7 1 4
2 1 1
9 16 6 9 7 3 1 1 6 4 1 2
III III II II II III II + III III II III II + III
II + III II II II II + III
II + III
II III II + III II + III III II
III III III III III III II III III III II + III III
TFB2M TFCP2 TFDP1 TFDP2 TFE3 TFEB TFG TFIP11 TFPT TFRC TGDS TGFB1 TGFB1I1 TGFBR1 TGFBR2 TGFBR3 TGFBRAP1 TGIF1 TGIF2 TGOLN2 TGS1 TH1L THADA THAP1 THAP10 THAP11 THAP2 THAP3 THAP4 THAP5 THAP6 THAP7 THAP9 THBS1 THBS3 THEM6 THG1L THNSL1 THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 THOP1 THRA THRAP3 THTPA THUMPD1 THUMPD2 THUMPD3
1 3
1 3
2 1 2
6 1 2
7 4 3 3
5
7
11
3
6
1
4 2 1 2
2 4 1 1 1
4 9 1 3 1
7 2 5 4 2 1 9 9 11 4 9 3
4
7
3
1 4
2
1
9
14
5 1 16
1
2
7
1
1 1 2
1
1
3 1 2
1
3 1
12 2 1 5 1
2 2 6 1 5 1 3
III III II II + III
II + III
III III II III III II + III II II II II + III III III III II II III III II + III II III III II III II II III II III II II
III
THYN1 TIA1 TIAL1 TIAM1 TICAM1 TIFA TIGD1 TIGD2 TIGD5 TIGD6 TIGD7 TIMELESS TIMM10 TIMM13 TIMM17A TIMM17B TIMM21 TIMM22 TIMM23 TIMM44 TIMM50 TIMM8A TIMM8B TIMM9 TIMMDC1 TIMP1 TIMP2 TIMP4 TINAGL1 TINF2 TIPARP TIPIN TIPRL TIRAP TJAP1 TJP1 TJP2 TK1 TK2 TKT TLCD1 TLE1 TLE2 TLE3 TLE4 TLK1 TLK2 TLN1 TLN2 TLR3 TLX3
1 1
2 1 5
5 2 14
1 1
5
8 2 1
3
1
2 1
5 1 1 1 1
1 1 1 5 1
2
1 1 2 10
1 9
2 1
2 1 3
2
3 2 3
6 2 1
6 2 2
1
2
1 4
1 2 2 1
1 5 1 1 4 1 1 2 1 15 1 3 14 2 2 4 1 5 3 1 2 5 4
9 1 2 2 3 4 1
III II + III III II II + III II II III III III II III II + III II II III
II II III III II II + III II III II III III II + III II II + III II + III
III III III III III II + III III II III II III III
TM2D1 TM2D2 TM2D3 TM4SF1 TM7SF3 TM9SF1 TM9SF2 TM9SF3 TM9SF4 TMA16 TMBIM1 TMBIM4 TMBIM6 TMC6 TMCC1 TMCC2 TMCO1 TMCO3 TMCO4 TMCO6 TMCO7 TMED1 TMED10 TMED2 TMED3 TMED4 TMED5 TMED8 TMED9 TMEM101 TMEM104 TMEM106B TMEM106C TMEM107 TMEM109 TMEM11 TMEM115 TMEM116 TMEM117 TMEM120A TMEM120B TMEM123 TMEM126A TMEM126B TMEM127 TMEM128 TMEM129 TMEM131 TMEM132A TMEM134 TMEM135
1 1 2 1
3
1 7
3 4 1 3 11
11
11
2
2 1 2 1 1
1 1
1 2
1 1 4 2 1 1 3 2 6
2 9 5 2
1 3 7 2 4 21 2 2 14 1 9 4 2 4 3 2 2 6 5
3 2 11 1 6
5 2 10 1 18
1 1 8 1 3
1 4 10 5 12 2
1
1 3 5
4
12
17
3
3 1 6
3
1 3
1 30 1 4 8 4 2
III III III III III III II III III III III II III III II III II + III II + III II + III II II III II II II II + III II + III II + III
II
II + III II II + III III III II II III III III
TMEM136 TMEM138 TMEM139 TMEM141 TMEM143 TMEM147 TMEM14A TMEM14B 1 TMEM14C 2 TMEM150A TMEM158 TMEM159 TMEM160 TMEM161A 3 TMEM161B TMEM161B-AS1 1 TMEM164 TMEM165 1 TMEM167A TMEM167B 1 TMEM168 2 TMEM170A 1 TMEM173 1 TMEM175 1 TMEM177 TMEM179B TMEM18 3 TMEM181 TMEM184A 4 TMEM184B 2 TMEM184C 1 TMEM185A TMEM185B 3 TMEM186 2 TMEM187 TMEM19 TMEM192 3 TMEM194A TMEM194B TMEM199 TMEM2 2 TMEM201 4 TMEM203 5 TMEM205 1 TMEM206 TMEM208 2 TMEM209 1 TMEM214 7 TMEM218 TMEM219 TMEM222
1
2 2
2
1
2
3 1 2
3 2
2 3 3
3 1 2 1 1 1 1
3 2 4 2 1 1 4 3
3 3 16 9 1 2 6 3 1 1 1 2
5 1 30 16 3 3 14 4 1 1 1 6
1 2 7 6 1 2 1 5 11 1 3
3 8 6 4 2 12
3
II + III III
III III III II + III III II II + III II II II III III II + III III II + III III III II + III III III III III III III III III III III II + III III III II + III III II
III III
TMEM223 TMEM230 TMEM231 TMEM234 TMEM237 TMEM241 TMEM242 TMEM245 TMEM25 TMEM30A TMEM33 TMEM37 TMEM38A TMEM38B TMEM39A TMEM39B TMEM41A TMEM41B TMEM42 TMEM43 TMEM45A TMEM47 TMEM48 TMEM5 TMEM50A TMEM50B TMEM51 TMEM54 TMEM55A TMEM55B TMEM57 TMEM59 TMEM59L TMEM60 TMEM62 TMEM63A TMEM63B TMEM64 TMEM65 TMEM66 TMEM67 TMEM68 TMEM69 TMEM70 TMEM79 TMEM80 TMEM87A TMEM87B TMEM8A TMEM8B TMEM9
2
4
3
1
2 1 2
2
7
4 2 1
11 2 2 3
3 5 2 2 1 3 2 4 1 3 16 2 4 7
1
3
2
5
1 1
3
1 2 1 1 2 1
1 2 1
1 5
2
2
1 1
4 1 1
3 6
1 1 1
2 1 4 3 1
3
4
3
1
6
1
1 7
1
1 9 1 4 1 6 2
II + III III III
III II III II II II + III
II II III III II + III II II + III
II + III II II II II + III II + III III III III II III III II + III II II + III II II II II + III II + III
TMEM97 TMEM99 TMEM9B TMF1 TMLHE TMOD3 TMPO TMPRSS3 TMSB10 TMSB4X TMTC1 TMTC3 TMTC4 TMUB1 TMUB2 TMX1 TMX3 TMX4 TNFAIP1 TNFAIP2 TNFAIP3 TNFAIP8 TNFAIP8L1 TNFRSF10A TNFRSF10B TNFRSF10D TNFRSF12A TNFRSF19 TNFRSF1A TNFRSF21 TNFSF9 TNIP1 TNIP2 TNK1 TNK2 TNKS TNKS1BP1 TNKS2 TNNC1 TNNT1 TNPO1 TNPO2 TNPO3 TNRC18 TNRC6A TNRC6B TNS1 TNS3 TOB1 TOB2 TOE1
2
5 1 2
1
4
1 1 1
1 1 2 3
4 1
5 1
5 1 2
2 6 2 1 1 2
3 3 3
9 2 3
8 1 1
8 2 3 2
1 1
3
2 1 21 4 2 2 2 3 1
8 1 3 3
12 1 1 2 8 3 1 6 3 1 2 11 4 7 1 8 4 15 4 3 1 7 5 3 1 2 2
5 11 2
3 2 2 13 9 4 3 3 8
18
5 3 5 30 15 4 10 6 3 14 3
II III III II II III II II II + III III II III II III III III III II III II + III
II + III II + III II + III II II + III II III III
III III III II + III II + III II III II III III II III II II III III
TOLLIP TOM1 TOM1L1 TOM1L2 TOMM20 TOMM22 TOMM34 TOMM40 TOMM40L TOMM5 TOMM6 TOMM7 TOMM70A TONSL TOP1 TOP1MT TOP2A TOP2B TOP3A TOP3B TOPBP1 TOPORS TOR1A TOR1AIP1 TOR1AIP2 TOR1B TOR2A TOR3A TOR4A TOX2 TOX4 TP53 TP53BP1 TP53BP2 TP53I13 TP53I3 TP53INP2 TP53TG1 TP73-AS1 TPBG TPCN1 TPD52 TPD52L2 TPGS1 TPGS2 TPI1 TPM1 TPM2 TPM3 TPM4 TPMT
1
2 3 1 1 1 3
1 1 1 2 2 1 2 2
2
1
3 1
1
1
10 5 1 3 7 7 2 4
1
6 2 5
1 2
4 1 6
1 1 5
1 2
1
4 5 3 14 18 11 5 4 24 1 1 4 1 5 1
1
1
4 9 2 1 3 5
2 4 1 5 10 12 3 1 14 1
2
1 7 3
1 10 2
4
6
3
5 7
8 15 5 3 13 1 4 6
1 1 6
2 4 4
1 1
II II + III III II III III III
II III II III II III II II III II + III II + III II III II + III III II III III II + III II III III III III III III II + III
II
II + III II
TPP1 TPP2 TPPP TPR TPRA1 TPRG1L TPRKB TPRN TPST1 TPST2 TPT1 TPT1-AS1 TPX2 TRA2A TRA2B TRABD TRADD TRAF2 TRAF3 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF6 TRAF7 TRAFD1 TRAIP TRAK1 TRAK2 TRAM1 TRAM2 TRAP1 TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TRDMT1 TRERF1 TREX1 TRIAP1 TRIB1 TRIB3
3
6
7
4
5
2
4
7 2 4
1
5 3
5
3
3 1 1
11
1 2
1 1 2 1 1 2
11 3 2 3 1 5 6
1 1 5
6
1
1 5 1
1 2
2
3 1 2 9
2 1 1 2
4 1 1
5 14 4 2 7 3 1 9 4 2 16 2 1 6 10 1 1 1
1
2 1
1 1
1
2
9
5 3
1 5 8
21 14
II II II
II II II II III II + III III
II II III III
II + III II II
II + III III III III II + III III III II III III III III III III
TRIM11 TRIM13 TRIM14 TRIM16 TRIM16L TRIM2 TRIM21 TRIM23 TRIM24 TRIM25 TRIM26 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM35 TRIM36 TRIM37 TRIM38 TRIM4 TRIM41 TRIM44 TRIM45 TRIM47 TRIM5 TRIM52 TRIM56 TRIM62 TRIM65 TRIM7 TRIM8 TRIML2 TRIO TRIOBP TRIP10 TRIP11 TRIP12 TRIP13 TRIP4 TRIP6 TRIT1 TRMT1 TRMT11 TRMT112 TRMT12 TRMT1L TRMT2A TRMT2B TRMT5
3 1 3
4 2 1 4 6 5
7 2 4 7 12 2 2
1 5 5 3 5
1 11 13 8 5 2 1 5 3 1
1
7 1 1 5
2
1 1 2
1
1 3
1 4 1 2 3 1
5 2 1
7 1 4 1
3 7 6 6 3 6 2 1 12 4 11 2 4
5
9 1 1
2
1 2
10 2 3 2 6 3
1
1
2
2
4
2 1
III III III III III III
III II + III III II + III III II + III III II + III II + III II III III III II II + III III II + III II + III III III III II III II + III II III III II III III III II + III III II + III II II II
TRMT6 TRMT61A TRMT61B TRMU TRNAU1AP TRNP1 TRNT1 TROAP TROVE2 TRPC1 TRPC4AP TRPM7 TRPS1 TRPT1 TRRAP TRUB1 TRUB2 TSC1 TSC2 TSC22D1 TSC22D2 TSC22D3 TSC22D4 TSEN15 TSEN2 TSEN34 TSEN54 TSFM TSG101 TSHZ1 TSHZ2 TSN TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN17 TSPAN3 TSPAN31 TSPAN33 TSPAN4 TSPAN5 TSPAN7 TSPAN9 TSPO TSPYL1 TSPYL2 TSPYL4 TSR1 TSR2 TSSC1
1 3 2 1
2
1 6 4 1 4
3
7
13
4
2
6
1 1
1
3 7
10 1 1 3
13 3
1 2
1 2 2 3 2
29 15 1 14 1 1 1 2 2 2 12 5 2
2
3 1
2 2 7
1
6
2 1 2 8
6 1 3 7
1 1
1 2
2
2 3 9 3 4 3 6 2
1 1
1
1 2 1 2
3 2 2 1
III III
III III III III III III
II + III
III III
III III III III III III III II + III III II III II + III II II II II II II III II II + III
TSSC4 TST TSTA3 TSTD2 TTBK2 TTC1 TTC12 TTC13 TTC14 TTC17 TTC19 TTC21B TTC23 TTC26 TTC27 TTC28 TTC28-AS1 TTC3 TTC31 TTC32 TTC33 TTC37 TTC38 TTC39C TTC5 TTC7A TTC7B TTC8 TTC9 TTC9C TTF1 TTF2 TTI1 TTI2 TTK TTLL12 TTLL4 TTLL5 TTLL7 TTPAL TTYH3 TUBA1A TUBA1B TUBA1C TUBA4A TUBB TUBB2A TUBB3 TUBB4B TUBB6 TUBD1
3
4 1 3
1
1 3 7 1
2 1
1 1
1 1
1
1
10 1 2
1 1
1
4
4
1 7 1 3 12
2 1
3
1
3 2
4 5 2
3 12 2 5 8 1 12
4 12 5 9 4 1 9 1 2 4 4
11 23 8 11 9 3 11 3 1 7 8
1 3
III II III III II
II II II + III II II + III III III II II III
III III III II II + III III II III III II III II II II III III III III II III II III II III III
TUBE1 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUFM TUFT1 TUG1 TULP3 TULP4 TUSC1 TUSC2 TUSC3 TUT1 TWF1 TWF2 TWISTNB TWSG1 TXLNA TXLNG TXN TXN2 TXNDC11 TXNDC12 TXNDC15 TXNDC16 TXNDC17 TXNDC9 TXNIP TXNL1 TXNL4A TXNL4B TXNRD1 TXNRD2 TYK2 TYMP TYMS TYRO3 TYSND1 TYW1 TYW3 TYW5 U2AF1 U2AF1L4 U2AF2 U2SURP UACA UAP1
1
3
1
1 2
3 1 9 2 2
1 2
1 1 3 15 4 7 1 1 2 3 2
6 2 1 2 2 1 4 12 36 10 18 2 1 5 1 1 2
1 4
9 1
2 2 1 1
3 10 3 4
1
3 1 1
8 1
14 4
8 2 1 1 19 5
2 2
1 1 5
2
1
3
6
7 1
16 3
1 1 2 1 1
1
2 7 1
2
II II III III III II II + III III II II + III III II III II III III III III II II III III III II
III II II III II III III II + III III II III II III III II II + III III II + III
UAP1L1 UBA1 UBA2 UBA3 UBA5 UBA52 UBA6 UBAC1 UBAC2 UBAC2-AS1 UBAP1 UBAP2 UBAP2L UBASH3B UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2I UBE2J1 UBE2J2 UBE2K UBE2L3 UBE2M UBE2N UBE2O UBE2Q1 UBE2Q2 UBE2R2 UBE2S UBE2T UBE2V1 UBE2V2 UBE2W UBE2Z UBE3A UBE3B UBE3C UBE3D UBE4A UBE4B
2 7 1
3 3 1
13 6 2 1
2 2 1 2
4 2
4 1
1
2
4 5
5 1 9
4
2 4
13 5 10 1 5 10 2 3
2 2 1 1
3
2 2 4 1 3
2
2 2
2 1
1
2 1 2 1 1 4
2 1 3 2 1 5 6
2 5 4 1 2 3 2 5 2 3 4 3 6 4 1 17 11
7 1 1 6
11 7 1 7 1
2 4 1 4
10 3 4 8
6
4 6
III II + III II + III III III III II II II II II + III II
III II + III II II III III III III III III II II III III III III III III III II III
III II + III II + III
UBFD1 UBIAD1 UBL3 UBL4A UBL5 UBL7 UBLCP1 UBN1 UBN2 UBOX5 UBP1 UBQLN1 UBQLN2 UBQLN4 UBR1 UBR2 UBR3 UBR4 UBR5 UBR7 UBTD1 UBTD2 UBTF UBXN1 UBXN11 UBXN2A UBXN2B UBXN4 UBXN6 UBXN7 UBXN8 UCHL3 UCHL5 UCK1 UCK2 UCKL1 UCP2 UEVLD UFC1 UFD1L UFL1 UFM1 UFSP2 UGCG UGDH UGGT1 UGGT2 UGP2 UHMK1 UHRF1 UHRF1BP1
2 4
1 5 1 7 2
1 1
3 3
2 1 3 2
7 4 5 3
3 2
2 2 2
3 6 1 1
1 1 3 1 1 1
1
1
1 1
1 6 2 16 2 2 1 13 13 7 2 5 5 1 2 4 3 3 2 1 7 15 1 2 1 3 1 1 2 1 1 7 1 1 2 1
1
3 1
1
1
1
1 1 2
2
3
2
4
10 2 13
III II III II + III III II II + III III III III III III III II II III III III III II II III III II III III II + III II + III II + III III III III III III II + III II III III III II + III III III
UHRF1BP1L UHRF2 UIMC1 ULBP3 ULK1 ULK3 ULK4 UMPS UNC119 UNC119B UNC13B UNC13D UNC45A UNC50 UNC93B1 UNG UNK UNKL UPF1 UPF2 UPF3A UPF3B UPP1 UPRT UQCC UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ URB1 URB2 URGCP URI1 URM1 UROD UROS USE1 USF1 USF2 USH1C USMG5 USO1 USP1 USP10 USP11 USP13 USP14
1 1 3
1
1 1
1
1 2
5 1 2
1 1 2 9 2
5 3
2 1 1 1 11 1 2 3 3 5
1 2 2 6 16 3 2
1
1
2 1
1 2 1 1
1
1
2 3 7
3 7 5
6 2 2 2 1 2 1 1 3 7 16 14 3
1 2 1 1
5
1
4 2
5 4
1 1 8 1
1 5 14 2
III III III III II II + III II II + III II + III
II II + III II + III III
II + III III II II + III II + III II III II + III
III III III III III
III II III III
USP15 USP16 USP18 USP19 USP20 USP21 USP22 USP24 USP25 USP28 USP3 USP30 USP31 USP32 USP33 USP34 USP35 USP36 USP37 USP38 USP39 USP4 USP40 USP42 USP43 USP45 USP46 USP47 USP48 USP5 USP53 USP54 USP6NL USP7 USP8 USP9X USPL1 UST UTP11L UTP14A UTP15 UTP18 UTP20 UTP23 UTP3 UTP6 UVRAG UXS1 UXT VAC14 VAMP1 VAMP2
1
1
3 1 1 2 5 1
11 1 3 4 2 5
3 2 1 1
3 2 3 2 1
3 3 1 20 3 1 6 3 17 2 1 3 2 14 3 8 1 2 4 9
1
1
2 2
3 4
1 1
1 3
2 2
2 3 1 2 2 1 1
5 1 3 6 4 1 10 5 2 1 4
2
1 1
2
1
2 3
1
2
1 2
6
1
3
II III III II + III III III II II + III III II III III III II II II + III II III III II + III II + III III II + III III II II
III II II + III II + III III
II + III II III III III III III II
VAMP3 VAMP4 VAMP7 VAMP8 VANGL1 VAPA VAPB VARS VASH2 VASN VASP VAT1 VAV2 VAV3 VBP1 VCL VCP VCPIP1 VDAC1 VDAC2 VDAC3 VDR VEGFA VEGFB VEZF1 VEZT VGLL4 VHL VIM VIT VKORC1 VKORC1L1 VLDLR VMA21 VMP1 VOPP1 VPRBP VPS11 VPS13A VPS13B VPS13C VPS13D VPS18 VPS25 VPS26A VPS26B VPS28 VPS29 VPS33A VPS33B VPS35
1
2
6 1
3
3
8 2 3 3
16 2 6 5
5
6
3
4
10 2 4 2
1 3 3 1
4 3 3 1 1
2 5
2 11 4
1
2 1
3 4 3
2 3 2
6 3 2 1 1 2 3 7
1 1
7 1
1
1
7 4 1 4 1
1 7 6 9 1 1 2 5 13 5 9 3 4 5 8 4 3 2 1 1 7 11 4 2 3 1 1 14 3 1 6
2
3 3
1
3
III III III II + III
II III III
III
III III III III III II II III III II II II III III III III
II II III II III
II II + III II + III
VPS36 VPS37A VPS37B VPS37C VPS39 VPS41 VPS45 VPS4A VPS4B VPS52 VPS53 VPS54 VPS72 VPS8 VRK1 VRK2 VRK3 VSIG10 VTA1 VTI1A VTI1B VWA5A WAC WAPAL WARS WARS2 WASF1 WASF2 WASF3 WASL WBP11 WBP2 WBP4 WBP5 WBSCR16 WBSCR22 WDFY1 WDFY2 WDFY3 WDHD1 WDR1 WDR11 WDR12 WDR13 WDR18 WDR19 WDR20 WDR24 WDR25 WDR26 WDR27
1
2
4 2 5
3
2
4 3 2
3 1 1 12 1 1 1 1 1 1 6 1 3 1 1 6 2 3 1 3 14 2 5 6 6
1 1
4
2
2
1 1 3
2 1 3 3
2 1
2 2
2 2 2 1 3
2 5 3 9 9
2 1 1 1 2 1
2
1
1
2 1 9
2 3 1
1 1
1
1 1 1
1 2 9 2 10 1
II + III III
III II III II II II + III III III II
II + III III III III
III III III III II II + III II + III III III
III
III
III II II II + III II + III
WDR3 WDR33 WDR34 WDR35 WDR36 WDR37 WDR4 WDR41 WDR43 WDR44 WDR45 WDR45L WDR46 WDR47 WDR48 WDR5 WDR53 WDR54 WDR55 WDR59 WDR5B WDR6 WDR60 WDR61 WDR62 WDR67 WDR7 WDR70 WDR73 WDR74 WDR75 WDR76 WDR77 WDR81 WDR82 WDR83 WDR83OS WDR85 WDR89 WDR90 WDR91 WDR92 WDSUB1 WDTC1 WDYHV1 WEE1 WFDC1 WFS1 WHAMM WHSC1 WHSC1L1
3 5
7 1
10
2
3
4
7
2 1 4
7 2 1 1
8 1 1 2
12 4 4 1 5 1
2
1
3
13
3 11
4 24
1 2 1 1 3 8 3
1 2 2 2
1 5 6
2 22 8
3
1 4
1
1 2 1 3 1 1 1 3 1
8 2 6 3
4 1 5 2 18 10
III II III II III II III II II II III II + III II + III II + III III III III III II II + III II + III III III
III III III II II + III III III II II + III II II II II II + III II II III
WHSC2 WIBG WIPF1 WIPF2 WIPI1 WIPI2 WISP2 WIZ WLS WNK1 WNT10B WNT3 WNT5A WNT7B WNT9A WRAP53 WRAP73 WRB WRN WRNIP1 WSB1 WSB2 WSCD1 WTAP WTIP WWC1 WWC2 WWC3 WWOX WWP1 WWP2 WWTR1 XAB2 XBP1 XIAP XK XPA XPC XPNPEP1 XPNPEP3 XPO1 XPO4 XPO5 XPO6 XPO7 XPOT XPR1 XRCC1 XRCC2 XRCC3 XRCC4
1 2 2 1 1 2 10 2 5 4
3 3 5 4 3 2 13 1 1 5 10
1 2 2 12 10 2 10 4 26 2 6 10 13
2
2 1 1
1 1 2 2 3
2 5 7 1
1 1
1 1 3
2 1 5 1
1 4 3
1 8 1 2
9 1 4
1
2
2 1 3 4 1 2 1 2
5 1 3 6 2 2 1 1
1
1
4 7 2 4 12 8 2 2 1 1 8
III II III
XRCC5 XRCC6 2 1 XRCC6BP1 XRN1 XRN2 XRRA1 II + III XXYLT1 3 2 III XYLB II + III XYLT1 6 4 XYLT2 1 III YAE1D1 1 III YAF2 II + III YAP1 1 4 II YARS 3 7 II YARS2 1 4 III YBEY III YBX1 1 II YDJC 1 4 YEATS2 2 III YEATS4 III YES1 III YIF1A 1 III YIF1B 2 YIPF1 III YIPF2 II YIPF3 2 4 II YIPF4 1 1 YIPF5 2 III YIPF6 2 III YKT6 3 YME1L1 1 II YPEL5 1 1 III YRDC III YTHDC1 2 YTHDC2 II + III YTHDF1 15 17 II + III, as the geneYTHDF2 target of siRNA,25 excluded in the data 31 analysis II + III YTHDF3 4 12 II YWHAB 3 4 III YWHAE 3 II YWHAG 4 8 YWHAH 1 II YWHAQ 1 3 II YWHAZ 2 7 II YY1 1 5 II YY1AP1 3 3 II + III ZADH2 1 5 ZAK ZBED3 2 II + III ZBED4 5 1 II + III ZBED5 2 4
7 2 2 1 2 2 19 3
6 9 5 2 3 2 2 2 2 3 5 1 5 1 5 4 2 1 3 2 20 30 21 8 6 20 7 6 7 6 12 10 1 3 10 4
II + III II + III II II + III II + III
II + III II + III II + III II II
II + III
III II + III II + III II II + III III III II III III II II III II + III III III III II + III III III III II
ZBED6 ZBTB1 ZBTB10 ZBTB11 ZBTB17 ZBTB2 ZBTB24 ZBTB25 ZBTB26 ZBTB3 ZBTB33 ZBTB34 ZBTB37 ZBTB38 ZBTB39 ZBTB4 ZBTB40 ZBTB41 ZBTB43 ZBTB44 ZBTB45 ZBTB46 ZBTB47 ZBTB48 ZBTB49 ZBTB5 ZBTB6 ZBTB7A ZBTB7B ZBTB8A ZBTB8OS ZBTB9 ZC2HC1A ZC3H10 ZC3H11A ZC3H12A ZC3H13 ZC3H14 ZC3H15 ZC3H18 ZC3H3 ZC3H4 ZC3H7A ZC3H7B ZC3H8 ZC3HAV1 ZC3HAV1L ZC3HC1 ZC4H2 ZCCHC10 ZCCHC11
2 2 1 1 4 2
1 1 2 3 1
3
1 3 2 7
4 1 1 5 2 2 1 2 1 1 9 7 8 8 2 2 2 1 1 1 2 1 4 2 11
10 5 11 5 1 14 5 3 4 4 4 4 2 14 12 26 16 4 5 6 9 4 1 3 2 7 7 20 2 7 1 9
2
2
1 2
4 2 1 1
5
9
5 2 1 9 4 19
2
4
1
1 1 1
8 1 1 1
1
1
2
II + III III II + III II + III III
II + III III III III III III II III III III II + III III II + III III II + III III II II
III III III III II II II II + III II + III
II II II + III II + III
ZCCHC14 ZCCHC17 ZCCHC2 ZCCHC24 ZCCHC3 ZCCHC4 ZCCHC6 ZCCHC7 ZCCHC8 ZCCHC9 ZCRB1 ZDBF2 ZDHHC12 ZDHHC13 ZDHHC14 ZDHHC16 ZDHHC17 ZDHHC18 ZDHHC2 ZDHHC20 ZDHHC23 ZDHHC24 ZDHHC3 ZDHHC4 ZDHHC5 ZDHHC6 ZDHHC7 ZDHHC8 ZDHHC9 ZEB1 ZEB1-AS1 ZER1 ZFAND1 ZFAND2A ZFAND2B ZFAND3 ZFAND5 ZFAND6 ZFAT ZFC3H1 ZFHX3 ZFP1 ZFP106 ZFP161 ZFP30 ZFP36 ZFP36L1 ZFP36L2 ZFP62 ZFP64 ZFP90
9
9
3
5
1
1 1
1
1
24 1 12 1 2 2 3 6
1
1
2 1 2 1 1 2
1 3 2 2 1 1
10 1 10 1 5 2 2 1
1 1 8 2 2 6 16 4 14 8 12 3 5 2 3
2 1 1 8
4 3 1
2
2 10 1 2
1 2 5
4 4 3 8
2
8
5 3 1 2 7 29 3 7 5 6 7 17 5 9
III II + III
II II + III III III
II + III II + III II + III
II + III II III II + III II II
II
III III II II + III
II + III II + III II + III
II + III
II + III II + III III II + III II + III
ZFPL1 ZFR ZFX ZFYVE1 ZFYVE16 ZFYVE19 ZFYVE20 ZFYVE21 ZFYVE26 ZFYVE27 ZFYVE9 ZGPAT ZHX1 ZHX3 ZIC2 ZIC5 ZKSCAN1 ZKSCAN2 ZKSCAN3 ZKSCAN4 ZKSCAN5 ZMAT2 ZMAT3 ZMAT5 ZMIZ1 ZMIZ2 ZMPSTE24 ZMYM1 ZMYM2 ZMYM3 ZMYM4 ZMYM5 ZMYM6 ZMYM6NB ZMYND11 ZMYND19 ZMYND8 ZNF10 ZNF101 ZNF12 ZNF121 ZNF131 ZNF133 ZNF134 ZNF136 ZNF138 ZNF14 ZNF140 ZNF142 ZNF143 ZNF146 ZNF148
3
3 2 7
2 11 6
1 3
1 2 3
2 4 7
2 1 2 1 1 1
3 1 6 3 3 1
1 1
1 2 2
1 1 1
1 4 2 1
1
2 1
4 4 4 3 3 6 6 10 10 4 2 3 5 3 1 6 6 2 2 4 3 1 1
2 2
3 6
8 8 1
2 3 2
2 6 3
1
1 1
9 7 6 1 3 2 5
2 2
1 6 1 8 4
4 7 1 8 11
1 3
II + III
III
II + III III II II II + III III
II + III
III
III II + III II + III
III II + III
ZNF16 ZNF160 ZNF17 ZNF174 ZNF175 ZNF18 ZNF180 ZNF182 ZNF184 ZNF185 ZNF187 ZNF189 ZNF192 ZNF193 ZNF195 ZNF197 ZNF2 ZNF200 ZNF202 ZNF205 ZNF207 ZNF212 ZNF213 ZNF215 ZNF217 ZNF219 ZNF222 ZNF226 ZNF227 ZNF23 ZNF232 ZNF236 ZNF238 ZNF239 ZNF24 ZNF248 ZNF251 ZNF259 ZNF26 ZNF260 ZNF263 ZNF266 ZNF267 ZNF268 ZNF271 ZNF274 ZNF275 ZNF276 ZNF277 ZNF280D ZNF281 ZNF282
1
1 1 2 1 1 2
1 1 3
2 2 1 1 1 3
1 2 1 5
2 1
6 6 4 2 5
1 3 3 5 7 1 4 7
1
4 2 11
4 1
4 3 1
1
1 1 1 1
1
1 1 3 3 3 3 4 1
1 2 3 1
1 1
1 1
3 2 2 1 1 6
3 2 6 4 1 4 4 3 5 5 3 2 10 5
II + III II + III II + III
II + III II + III II + III
II + III III III III
II + III
III III II II III
II + III
II + III III
III II + III
III II + III
ZNF286A ZNF292 ZNF295 ZNF3 ZNF30 ZNF302 ZNF304 ZNF317 ZNF318 ZNF319 ZNF320 ZNF323 ZNF324 ZNF326 ZNF329 ZNF330 ZNF331 ZNF335 ZNF337 ZNF33A ZNF341 ZNF343 ZNF346 ZNF35 ZNF350 ZNF354A ZNF354B ZNF358 ZNF362 ZNF367 ZNF383 ZNF384 ZNF385A ZNF394 ZNF395 ZNF397 ZNF398 ZNF407 ZNF408 ZNF41 ZNF410 ZNF414 ZNF416 ZNF420 ZNF426 ZNF428 ZNF430 ZNF434 ZNF436 ZNF44 ZNF444 ZNF445
2 1 4
2 3 3 1
8 7 12 3
2 2 3
1 2 2 2 2
3 4 10 10 9 10
1
1
7
2
3
1 1 1
1
3 2
1 3 2 2 6 5 1 3
1
1
3
9 1
1 3
6
3 3
7 1 4 9 3
1
4 3
1 3
1 1 1 2
3 2 3 17 2 4 3
2 3
1 3 3 5
2 4
3 11
II + III II + III II + III
II + III II + III II + III II + III III III III II + III
III II + III
II + III II + III II + III
II + III
II II II + III
II + III III II II
ZNF446 ZNF449 ZNF45 ZNF451 ZNF460 ZNF473 ZNF48 ZNF480 ZNF484 ZNF485 ZNF496 ZNF498 ZNF500 ZNF503 ZNF507 ZNF510 ZNF511 ZNF512 ZNF512B ZNF513 ZNF516 ZNF521 ZNF524 ZNF526 ZNF529 ZNF530 ZNF543 ZNF544 ZNF548 ZNF550 ZNF552 ZNF556 ZNF557 ZNF558 ZNF561 ZNF562 ZNF566 ZNF567 ZNF57 ZNF574 ZNF576 ZNF579 ZNF580 ZNF581 ZNF584 ZNF586 ZNF589 ZNF592 ZNF593 ZNF598 ZNF605 ZNF609
1 1 1 9 1
3 2
2 4 1 5 10 4 1 3 1
3 1
5 4 1 6 2
1
4 1
3
4
2 1
3 2 1 1
1
1
19 18 10 2 6 3 13 8 2 13 4 4 1 1 7 6 3 1 14 1 4 7 6 4 2 7 3
1 1
3 1 2 6
2 1 1 3
5 3 1
6 8 2
1 3
3 10 1 5 1 3 2 1 1 9
2 1 11
9 3 15
2 1 1 1
II + III
II + III II + III II + III II + III II + III
II
II + III
II + III II + III II + III III II + III II + III III II + III II
II II + III
III II + III II + III II
III II + III
ZNF611 ZNF613 ZNF614 ZNF615 ZNF616 ZNF622 ZNF623 ZNF627 ZNF629 ZNF638 ZNF639 ZNF641 ZNF644 ZNF646 ZNF652 ZNF655 ZNF664 ZNF668 ZNF669 ZNF670 ZNF672 ZNF673 ZNF675 ZNF684 ZNF687 ZNF688 ZNF689 ZNF691 ZNF692 ZNF7 ZNF700 ZNF703 ZNF706 ZNF707 ZNF710 ZNF721 ZNF74 ZNF740 ZNF746 ZNF747 ZNF749 ZNF75A ZNF76 ZNF761 ZNF764 ZNF766 ZNF768 ZNF77 ZNF770 ZNF771 ZNF776 ZNF777
2
1
1 1 2 1 6
2
1 2 1 4 1 4 3 1 1 5 10 4 2 5
5 5 1 2 10 1 11 7 4 5 4 29 8 1 11 2 2 17 2 9 1 21 1 9 1 1 5 9 20
4
10 3 6
6
9
1 1
3 1
1 6
2 11
2 2 1
2 1
7 2 5
1 5
2 1
9 10
1 1
3 1 4 3 1 4
2 1
1
7
2 7 1 3 5 1 8 2 10
2 1
4 5
II + III
II
II + III II + III
II + III
II + III II + III III II + III III III III III III III II + III III II + III III III II + III
II + III II + III II + III II + III III
III II II + III
ZNF778 ZNF780A ZNF784 ZNF786 ZNF787 ZNF789 ZNF79 ZNF791 ZNF8 ZNF800 ZNF808 ZNF821 ZNF823 ZNF83 ZNF830 ZNF831 ZNF839 ZNF84 ZNF841 ZNF865 ZNF92 ZNFX1 ZNFX1-AS1 ZNHIT1 ZNHIT2 ZNHIT3 ZNHIT6 ZNRD1 ZNRF1 ZNRF2 ZNRF3 ZP3 ZRANB1 ZRANB2 ZRANB3 ZRSR2 ZSCAN12 ZSCAN16 ZSCAN2 ZSCAN21 ZSCAN29 ZSCAN30 ZSWIM1 ZSWIM3 ZSWIM4 ZSWIM6 ZSWIM7 ZUFSP ZW10 ZWILCH ZWINT ZXDC
2
3 2
6 4
2
2
2 10
1 3 1
5 4 4 1
2 3 13 6 5 1 4
14
13
27 2
1 7
2 11 1 3 3
3 25 3 9 6 1 2
5
1 1 1 2 1 11
1
2
2 1
1
1
2 3 1 1 8
2
1 1 17
5 3
1
3
1
2 1
3 4
3 1 5 4 10 8
3 3
1 1 3 4 7
3 2
II II + III
ZYG11A ZYG11B ZYX ZZEF1 ZZZ3
3
2 1
1
2
2 2 3 1 5
RIP / Enrich-log2(IP/Input)
Ribsome profiling / change foldlog2(siYTHDF2 /siControl)
rep1-polyA input
Translation Efficiency RPF(Source mRNA input rep2-ribominus Data to Figure (Source Data (Source Data input 2b) to Figure 2a) to Extended Data Figure
1.752 -2.976 -0.249 -0.084 -1.843 -1.802 0.275 -2.060 0.207 0.550 2.282 -1.140 -1.811 0.447 -0.810 -0.619 0.118 -1.399 0.894 -0.696 0.690 -1.473 0.610 1.752 0.285 -0.646 1.337 -0.258 -0.226 0.731 -0.358 -1.313 0.495 0.376 -0.299 -0.321 -0.258 0.480 -1.161 2.460
2.973 -2.063 0.700 -0.559 -2.433 -2.260 0.213 -1.456 0.574 0.750 1.300 -2.279 -0.985 0.165 -0.098 0.111 -0.610 -0.912 -0.287 -0.340 -0.301 -1.069 0.574 2.106 0.272 -0.030 0.295 -0.331 0.497 -0.159 0.199 -2.326 0.815 0.573 0.189 -0.879 -1.084 1.207 -0.564 1.534
-0.124 -0.224 -0.469 1.174 -0.155 -0.099 -0.387 0.096 0.248 0.399 0.329 0.031 -0.249 -0.105 -0.322 -0.042 0.850 0.228 0.265 -0.023 -0.053 0.014 0.170 -0.061 -0.003 -0.206 -0.018 0.710 -1.651 -0.063 0.115 -0.084 0.249 0.142 0.291 -0.598 0.241 0.437 0.084 0.140
-0.653 -0.158 -0.004 0.391 0.026 -0.129 -0.011 -0.286 0.346 0.484 0.289 -0.165 -0.037 0.397 -0.463 -0.178 0.678 -0.323 0.755 -0.484 0.257 0.137 -0.033 -0.148 -0.298 -0.102 0.266 0.318 -0.757 0.431 -0.107 0.760 0.520 0.617 0.088 0.489 0.284 -0.273 -0.021 -0.215
0.529 -0.066 -0.465 0.782 -0.181 0.030 -0.376 0.382 -0.098 -0.086 0.040 0.195 -0.211 -0.502 0.141 0.136 0.172 0.552 -0.489 0.461 -0.310 -0.124 0.203 0.087 0.294 -0.104 -0.284 0.392 -0.894 -0.494 0.222 -0.844 -0.272 -0.475 0.203 -1.087 -0.043 0.711 0.106 0.354
-2.877 2.371 -1.514 0.393 0.037 -1.608 0.308 0.734 0.526 -0.403 0.458 1.162 2.028 0.791 -1.640 0.751 -2.481 0.341 0.213 -0.994 -1.262 0.531 0.240 0.080 0.886 0.171 -1.379 -0.580 -0.206 -2.400 0.264 -1.130 -2.429 -2.771 0.268 -0.896 0.093 -1.280 -0.081 -2.706 0.333 -2.464 0.036 -1.577 -0.095 -1.259 -2.072 0.516 -2.653 -2.406 -0.453
-2.403 2.315 -1.211 0.004 -0.739 -1.000 -0.181 0.902 0.998 -1.113 0.738 1.467 1.339 0.153 -1.364 0.879 -2.052 0.411 0.957 -0.609 -1.302 0.461 0.327 0.326 1.010 0.164 -1.809 -0.166 -0.841 -1.748 -1.220 -0.427 -2.446 -2.507 0.612 -0.719 -0.735 -1.078 0.275 -2.464 -0.732 -1.780 -0.155 -1.432 -0.723 -0.975 -1.889 0.959 -1.007 -2.163 -0.724
-0.674 0.148 -0.141 -0.542 0.008 -0.242 0.356 0.305 0.559 -0.016 -0.540 -0.177 0.604 -0.356 -0.201 -0.170 0.202 -0.115 -0.106 -0.244 -0.101 0.233 0.109 0.193 0.193 -0.055 0.162 0.458 -0.303 -0.485 0.053 -0.320 -0.110 0.494 0.213 0.236 0.329 0.038 0.191 -0.021 -0.518 0.172 -0.326 0.294 0.817 -0.003 0.117 0.704 -0.196 -0.124 0.177
-0.695 0.342 -0.256 -0.124 -0.133 -0.374 0.196 -0.517 -0.320 -0.029 -0.202 -0.246 0.567 -0.038 -0.724 -0.074 -0.194 -0.211 -0.260 -0.370 0.561 0.484 0.037 0.305 -0.217 0.144 -0.100 -1.024 0.328 0.161 0.119 -0.717 0.145 0.286 -0.021 -0.388 0.165 -0.268 0.006 -0.543 -0.113 0.551 0.097 -0.464 0.364 0.226 -0.005 -0.262 -0.288 -0.395 -0.231
0.021 -0.193 0.115 -0.418 0.141 0.132 0.161 0.822 0.879 0.013 -0.339 0.069 0.037 -0.318 0.523 -0.096 0.396 0.096 0.154 0.126 -0.662 -0.251 0.072 -0.112 0.410 -0.200 0.262 1.482 -0.631 -0.647 -0.066 0.398 -0.255 0.209 0.235 0.623 0.164 0.306 0.185 0.521 -0.405 -0.379 -0.423 0.758 0.454 -0.228 0.122 0.966 0.092 0.272 0.408
0.343 0.960 -3.345 1.104 -0.993 2.510 -0.765 -0.142 1.416 0.399 0.870 -1.014 -0.922 -1.641 -0.782 -1.906 -1.057 -0.194 -1.087 -0.670 -0.646 -1.267 -0.634 -1.323 -0.474 1.572 -1.319 0.847 2.584 0.484 1.023 -1.428 -1.259 -1.499 -0.540 1.460 -1.417 1.667 1.060 0.253 2.082 1.769 1.289 1.217 2.259 -0.281 -1.017 0.823 -0.286 -0.994 1.262
-0.391 0.946 -3.511 1.294 -0.844 1.858 0.747 0.291 0.818 -0.319 -0.315 -0.729 -0.351 -0.296 0.109 -1.922 -0.590 1.498 0.000 -1.518 -0.206 -0.851 -1.211 -2.171 -0.577 1.350 -1.992 0.251 2.175 0.763 0.506 -0.723 -1.614 -1.169 -1.267 0.261 -1.127 0.619 0.629 -0.541 1.509 1.002 1.278 1.404 1.557 -0.771 -0.770 0.978 -0.037 -0.362 1.120
0.147 0.391 -0.004 0.087 -0.182 -1.061 0.095 -0.015 0.560 -0.033 0.334 0.732 0.265 -0.392 -0.069 0.044 -0.828 0.300 -0.353 0.230 -0.396 -0.065 0.134 -0.036 0.034 0.444 0.606 0.228 -0.192 -1.270 0.225 0.130 0.564 -0.619 0.074 0.009 -0.932 -0.041 -0.158 -0.296 -0.769 0.021 0.073 -0.351 -0.369 -0.251 -0.451 0.343 -0.154 0.573 -0.098
-0.227 0.006 -0.136 0.443 -0.433 -0.425 0.569 -0.114 0.142 0.265 0.631 0.027 -0.752 0.027 -0.240 0.323 -0.302 0.233 0.268 -0.038 -0.176 -0.467 0.918 0.267 -0.283 -0.155 0.475 0.298 0.080 -0.608 -0.088 -0.323 -0.521 -1.009 0.077 0.853 -0.753 0.240 0.756 0.331 -0.090 0.647 0.329 -0.022 -0.140 -0.581 -0.283 -0.244 -0.230 0.102 -0.204
0.374 0.385 0.132 -0.356 0.252 -0.636 -0.475 0.100 0.418 -0.298 -0.297 0.705 1.017 -0.419 0.171 -0.279 -0.526 0.067 -0.621 0.268 -0.220 0.402 -0.784 -0.303 0.316 0.599 0.131 -0.069 -0.272 -0.662 0.313 0.453 1.085 0.390 -0.003 -0.844 -0.179 -0.281 -0.914 -0.627 -0.679 -0.626 -0.256 -0.329 -0.230 0.330 -0.168 0.587 0.076 0.472 0.105
-0.184 2.044 1.814 -0.509 -0.923 0.201 -0.897 -2.700 -2.330 1.115 -0.961 0.979 2.213 3.305 2.291 1.855 -0.942 1.305 1.805 0.836 -1.649 -2.634 -1.954 -0.180 -0.784 -0.372 0.543 -3.421 1.073 -0.786 1.617 1.512 0.410 0.251 -1.401 2.184 -1.243 0.926 -0.717 -0.992 0.206 -1.857 -0.722 -0.555 0.913 -0.259 -2.840 -0.967 0.808 1.430 1.904
-0.041 1.547 1.716 -0.018 -0.685 -1.232 -1.319 -2.659 -2.116 0.763 -1.405 1.293 2.497 2.573 2.048 1.778 -0.522 1.543 2.326 1.157 -1.269 -2.011 -1.337 -1.028 -0.869 -0.632 0.060 -2.728 0.853 -0.695 1.441 0.579 0.816 0.164 -1.315 1.669 -1.612 1.212 -0.026 -0.630 -0.908 -1.614 -1.388 -0.706 0.173 -0.293 -2.281 -0.446 1.100 0.400 2.404
-0.587 -0.363 0.009 0.049 -0.271 -1.050 0.100 -0.446 0.173 0.125 -0.667 -0.159 0.233 0.487 0.032 -0.284 -0.076 0.009 -0.062 -1.149 0.044 -0.127 -0.077 0.251 -0.004 -0.276 0.336 0.237 -0.204 -0.214 -0.594 0.848 0.534 0.067 -0.265 0.191 -0.288 0.221 0.111 0.169 -0.552 -0.847 -0.050 -0.192 -0.023 -0.249 -0.184 -0.282 -0.071 0.293 0.076
-0.175 -0.371 -0.002 0.102 -0.365 -0.083 0.720 -0.622 0.049 -0.341 -0.724 -0.445 0.235 0.342 -0.496 -0.367 -0.628 -0.110 -0.542 -0.978 -0.214 -0.540 -0.211 0.240 -0.715 -0.258 -0.431 -0.572 0.206 -0.129 -0.208 0.898 0.205 0.494 -0.846 0.171 -0.095 0.100 -0.150 -0.336 0.087 -0.138 -0.017 0.602 0.604 -0.491 -0.011 -0.453 -0.178 0.014 0.138
-0.411 0.008 0.011 -0.053 0.094 -0.967 -0.621 0.176 0.124 0.467 0.057 0.286 -0.003 0.144 0.528 0.083 0.552 0.119 0.480 -0.171 0.258 0.414 0.134 0.011 0.711 -0.018 0.767 0.809 -0.410 -0.085 -0.386 -0.050 0.329 -0.427 0.581 0.020 -0.193 0.121 0.261 0.504 -0.639 -0.709 -0.034 -0.794 -0.627 0.241 -0.173 0.171 0.106 0.279 -0.062
-0.580 -0.287 -0.560 -0.583 1.467 -2.028 -0.820 1.875 -1.350 -0.776 -0.566 1.939 -0.030 1.239 1.380 2.431 2.084 -1.764 -0.186 -2.562 -1.269 -0.495 -1.325 -2.245 -0.850 -2.349 0.368 -1.851 -1.578 0.294 2.214 1.690 1.234 -0.068 1.450 0.077 1.081 -2.205 -0.646 -1.141 -0.161 -0.564 -2.467 -2.600 -1.897 -1.022 -2.562 -0.200 0.711 0.362 -0.910
-1.124 0.218 -1.369 0.078 0.192 -1.510 -0.806 0.995 -1.055 -1.216 -0.702 2.288 -0.758 1.216 1.363 0.956 2.031 -0.963 -0.416 -1.985 -0.978 -0.040 -1.422 -1.605 -1.079 -1.791 0.338 -1.388 -1.554 -0.650 1.968 0.955 0.287 0.196 1.230 -0.207 1.604 -1.212 -0.467 -0.718 -0.622 0.072 -2.341 -2.271 -1.320 -0.368 -1.150 0.566 0.184 -0.007 -0.301
-0.786 0.191 0.102 -0.327 0.375 0.622 -0.272 0.439 0.296 0.065 -0.016 0.118 0.137 0.567 -0.406 0.466 0.208 0.068 1.411 0.197 -0.247 -0.159 0.428 0.030 0.103 -0.185 0.329 0.291 -0.105 0.027 -0.314 0.004 0.399 0.301 -0.053 0.262 0.151 0.195 0.109 -0.185 0.148 0.019 -0.267 0.085 0.165 0.166 -1.205 0.327 0.676 0.369 -0.026
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1.817 1.447 2.971 2.803 1.904 0.952 2.782 3.735 1.321 1.330 2.162 1.677 1.525 2.220 1.464 0.236 0.290 1.038 2.214 2.724 1.844 1.110 1.903 1.015 1.956 0.834 2.288 2.158 -1.062 2.201 2.609 1.531 -0.358 1.284 0.289 0.509 1.214 0.669 1.846 1.255 1.804 1.278 -0.736 1.041 2.077 1.436 0.781 2.191 1.813 -0.407 2.432 0.266
1.375 1.000 1.717 2.154 1.321 1.095 2.233 2.795 1.707 0.681 1.541 1.117 0.583 2.863 0.602 -0.164 0.515 1.528 1.901 1.617 2.146 1.224 1.183 0.628 2.278 0.811 1.695 2.344 -0.354 2.241 2.045 3.507 -0.026 1.623 0.659 0.285 2.091 0.727 2.031 1.615 1.144 1.077 -0.331 0.617 1.951 1.137 1.944 2.066 0.355 -0.057 1.262 1.059
0.551 -0.201 0.169 0.085 0.232 0.171 -0.033 0.678 0.179 0.510 0.260 0.682 -0.090 0.219 -0.272 -0.264 -0.356 0.146 -0.040 0.340 -0.135 0.398 0.738 0.310 0.038 0.159 0.777 -0.227 0.167 0.396 0.531 -0.438 -0.017 -0.812 -0.087 0.536 0.042 0.070 0.395 -0.044 0.254 -0.225 0.448 -0.333 0.546 0.212 0.108 0.465 0.093 1.053 0.671 0.157
0.738 -0.215 0.107 0.215 0.416 0.044 -0.017 -0.047 0.755 1.001 -0.150 0.342 0.251 0.075 -0.376 0.180 0.176 -0.172 -0.105 0.305 -0.222 0.160 0.822 0.009 0.050 -1.089 0.242 -0.104 -0.422 0.060 0.518 -1.746 0.222 -0.497 -0.366 0.960 -0.043 0.096 -0.043 -0.155 -0.296 -0.062 0.131 0.537 -0.393 0.162 -0.500 -0.099 0.549 -0.843 0.574 -0.003
-0.187 0.014 0.062 -0.130 -0.185 0.127 -0.016 0.725 -0.575 -0.491 0.410 0.340 -0.341 0.143 0.104 -0.443 -0.532 0.318 0.065 0.035 0.087 0.238 -0.084 0.301 -0.013 1.248 0.536 -0.123 0.590 0.336 0.013 1.307 -0.239 -0.315 0.279 -0.424 0.085 -0.026 0.438 0.111 0.550 -0.164 0.317 -0.870 0.939 0.050 0.608 0.564 -0.456 1.896 0.098 0.160
2.745 1.963 0.421 2.052 -0.304 0.768 2.548 2.031 2.722 2.630 2.114 1.189 2.922 2.048 0.545 3.110 1.479 0.693 1.846 1.253 -0.393 2.094 -3.593 -1.618 1.487 -1.094 -1.697 -2.289 -0.248 1.288 2.145 -0.892 2.946 -2.116 0.829 -2.198 2.168 0.313 0.871 1.412 2.031 1.446 2.157 3.025 1.180 2.416 -2.175 0.036 0.471 -0.582 0.262 1.278
2.215 1.020 1.125 2.244 0.362 0.745 2.278 1.374 2.193 1.695 1.166 1.693 2.168 1.353 0.996 2.432 1.419 0.273 1.436 2.317 -0.361 1.890 -3.334 -1.307 1.967 -1.038 -1.506 -1.992 0.161 0.650 1.951 -0.764 2.324 -3.334 0.082 0.056 1.553 1.178 1.195 1.098 1.578 1.492 2.119 2.742 1.403 1.616 -1.707 -0.286 -0.339 -1.758 0.441 1.153
0.778 0.237 0.168 0.200 -0.005 0.113 0.128 0.336 -0.146 0.512 0.531 0.892 0.508 0.876 0.140 -0.993 0.190 0.415 0.096 0.560 0.693 0.142 -0.034 0.141 0.430 -0.013 -0.275 -0.162 0.404 0.005 0.295 0.723 0.508 0.132 0.140 0.632 0.934 0.297 0.708 0.252 0.398 0.632 0.178 0.471 0.207 -0.101 0.430 0.274 0.017 0.291 0.361 0.206
-0.046 0.461 -0.296 -0.048 -0.611 -0.743 -0.110 0.398 -0.333 0.026 0.009 0.036 0.048 0.644 -0.405 -0.692 0.012 0.144 0.436 -0.873 1.186 0.087 -0.733 -0.851 -0.419 0.067 0.380 -0.565 -0.664 -0.520 0.014 -0.473 0.211 0.638 0.285 0.797 0.094 0.331 -0.141 0.315 -0.130 0.326 -0.277 0.123 -0.411 -0.197 -0.363 0.199 0.229 0.139 0.254 0.031
0.823 -0.224 0.464 0.248 0.606 0.855 0.238 -0.063 0.187 0.487 0.521 0.856 0.460 0.232 0.545 -0.301 0.178 0.271 -0.340 1.433 -0.494 0.055 0.700 0.993 0.849 -0.081 -0.655 0.403 1.068 0.525 0.281 1.196 0.297 -0.506 -0.145 -0.165 0.840 -0.034 0.848 -0.062 0.528 0.306 0.455 0.348 0.618 0.096 0.794 0.075 -0.212 0.152 0.107 0.175
2.160 1.912 -3.666 0.734 2.365
1.510 0.760 -1.672 0.636 0.855
0.376 0.069 -0.409 0.180 -0.070
0.042 -0.027 -0.697 0.289 -0.002
0.334 0.096 0.289 -0.109 -0.067
mRNA lifetime / change foldlog2(siYTHDF2 /siControl) mRNA lifetime ( Source Data to Figure 2cd) 1.199 2.708 0.417 -0.540 0.054 -1.229 0.165 #NUM! 0.701 1.058 -0.036 -0.163 0.210 -0.328 #NUM! #NUM! 0.135 #NUM! -0.782 0.329 -0.683 #NUM! 0.615 0.571 0.459 #NUM! -0.148 -0.266 1.158 -0.557 0.420 -0.591 0.533 0.216 0.549 -0.936 -0.576 -0.027 -2.323 0.512
#NUM! 0.403 1.881 -0.183 #NUM! -0.498 -0.006 0.080 #NUM! -0.301 -0.208 0.276 0.425 -0.267 -0.108 #NUM! -1.133 0.087 0.272 -0.265 -0.770 0.188 0.635 0.402 -0.502 -1.560 #NUM! -0.594 -0.946 0.390 -0.045 #NUM! #NUM! -1.043 0.317 #NUM! 0.065 0.292 0.239 0.416 -0.985 -0.066 -0.322 0.727 -0.201 1.405 -0.078 1.235 #NUM! 0.947 -0.353
0.022 0.994 -1.344 0.785 0.334 -0.310 0.419 1.008 -0.433 -0.061 -0.678 -1.636 #NUM! 0.884 2.366 -1.544 #NUM! 0.955 1.363 -0.682 0.216 #NUM! -0.611 -0.431 0.190 0.766 -0.652 0.149 0.369 0.511 0.308 0.190 -0.502 1.154 -1.263 -0.286 #NUM! -0.052 -0.908 -1.696 0.219 0.547 0.147 0.598 -0.022 0.257 1.454 0.318 0.175 1.475 0.284
-0.817 1.051 0.167 -0.109 0.442 -0.939 -0.874 #NUM! 1.583 0.074 -3.986 0.319 0.273 0.455 0.329 -0.282 1.571 0.314 0.727 -0.282 1.103 0.399 1.684 -0.119 #NUM! -0.082 0.399 #NUM! 0.347 #NUM! 0.236 0.332 0.521 0.527 -0.974 0.242 -1.532 0.568 0.855 0.648 -0.184 -0.006 -0.235 -0.633 -0.458 #NUM! 1.945 0.706 0.574 -0.068 0.454
-0.007 #NUM! -0.710 #NUM! -0.182 #NUM! 0.156 0.167 #NUM! -1.457 -1.771 0.213 -0.578 0.269 0.052 0.309 0.103 -0.163 -2.038 0.582 -0.899 0.324 -1.530 -1.557 0.190 -0.431 0.246 1.229 -0.246 -0.790 0.345 0.183 -0.141 0.055 0.432 -0.261 0.350 0.680 -0.180 0.508 0.066 0.450 0.517 2.189 0.373 #NUM! 0.631 1.670 -0.024 0.224 -0.365
0.052 #NUM! -0.283 0.409 0.820 -0.764 4.657 1.317 -0.778 #NUM! #NUM! -0.686 #NUM! -1.403 0.100 0.339 0.238 0.774 0.024 0.294 0.363 -0.147 -0.058 0.252 -0.668 -0.103 0.016 0.217 0.409 0.538 0.550 #NUM! #NUM! 0.100 0.409 1.201 0.266 1.002 0.114 2.611 0.462 0.208 0.488 -2.329 -0.112 0.750 -0.626 0.609 -2.052 0.260 0.269
-1.228 -1.022 #NUM! 0.195 -0.125 -1.798 #NUM! -0.095 #NUM! #NUM! -0.985 -0.156 -0.485 0.632 0.095 -0.051 -0.375 -0.162 0.301 -0.171 0.142 0.434 0.179 -0.344 #NUM! -0.178 #NUM! 0.099 0.098 0.152 -0.262 0.048 -0.203 -1.503 0.198 0.717 0.486 3.266 0.101 -0.012 0.310 0.381 0.400 0.247 0.892 #NUM! 0.210 1.099 0.626 0.173 -0.660
-1.639 0.451 -0.333 -0.737 -0.485 -0.124 -0.047 0.017 -0.377 #NUM! 0.673 #NUM! #NUM! -0.364 #NUM! #NUM! -0.943 -1.056 #NUM! 0.075 -0.590 #NUM! 0.823 -0.847 -0.105 #NUM! 1.706 -0.625 -1.589 2.913 -1.029 0.541 -0.744 -0.324 -0.794 0.199 -0.058 0.677 0.619 -0.003 0.325 #NUM! 0.264 #NUM! 0.071 -0.939 0.138 #NUM! 0.490 0.161 0.643
-0.504 -0.196 #NUM! -0.959 #NUM! 1.339 0.264 -0.237 -0.244 0.841 -0.505 0.026 -0.137 -0.439 #NUM! -0.150 0.086 -0.824 0.524 #NUM! 0.480 -0.044 0.544 0.212 -1.070 #NUM! 0.326 0.998 0.522 -0.295 0.066 0.060 -0.077 0.299 #NUM! -0.457 0.072 #NUM! 0.242 0.373 1.014 0.259 0.212 -0.637 0.170 0.458 0.538 0.690 0.215 0.272 0.540
0.135 1.951 0.322 0.523 #NUM! -0.432 0.845 0.421 -0.216 1.414 0.750 0.447 0.308 0.161 0.629 0.030 -0.544 0.096 0.332 -0.009 0.421 0.548 0.179 0.186 0.282 -0.023 0.385 -0.126 -0.054 -0.925 -0.188 -0.325 #NUM! #NUM! 0.291 #NUM! 0.247 -0.145 0.080 -0.442 -0.487 #NUM! -0.493 -0.257 0.311 -0.587 0.100 0.338 1.098 0.860 0.719
0.402 -0.122 -0.181 -0.957 0.255 -0.183 -0.216 -0.219 -0.665 0.059 #NUM! #NUM! -0.693 0.904 -0.661 0.065 #NUM! #NUM! 0.364 0.042 #NUM! 0.767 -0.139 0.022 #NUM! #NUM! 0.059 0.019 0.121 0.427 0.584 0.610 0.518 0.386 -2.407 0.087 1.433 -0.681 0.018 0.017 0.322 -0.315 0.323 -1.264 #NUM! 1.892 1.156 0.153 -1.673 #NUM! 0.190
#NUM! #NUM! 0.234 -0.141 0.303 0.324 -0.071 -0.483 0.214 #NUM! #NUM! 0.073 -0.767 0.273 0.014 0.530 0.207 0.862 -0.296 #NUM! -0.218 0.203 -0.293 -1.058 0.975 0.043 0.087 0.178 0.166 -0.165 -0.414 #NUM! 0.170 0.748 0.407 0.168 0.841 -0.422 -0.050 0.338 -0.188 0.314 #NUM! #NUM! -0.652 0.428 -0.977 -0.653 -0.834 #NUM! 0.072
-1.071 0.000 -0.295 -0.516 -0.661 0.563 -0.485 -0.128 -0.525 -0.201 #NUM! #NUM! #NUM! #NUM! -2.312 #NUM! -1.864 -0.438 #NUM! #NUM! #NUM! -0.650 #NUM! 0.210 0.959 #NUM! #NUM! 4.925 -0.404 #NUM! #NUM! 0.132 -0.384 #NUM! -0.599 0.222 -0.760 -2.067 -0.689 #NUM! -0.049 -0.566 -0.732 -0.310 0.381 0.070 -0.063 -0.324 -0.450 #NUM! -0.052
#NUM! -0.197 0.402 -0.141 -0.159 0.344 -0.552 0.612 0.089 #NUM! -0.313 0.489 0.042 0.194 0.413 0.581 -0.166 0.481 0.214 #NUM! 0.510 0.864 0.327 0.674 0.567 0.271 -0.872 -0.626 -0.377 -0.347 #NUM! -0.290 0.530 0.356 0.128 0.541 -0.013 0.758 0.351 #NUM! -0.389 1.001 0.543 -0.198 0.278 #NUM! #NUM! 0.487 #NUM! -0.228 0.083
0.274 #NUM! 0.311 0.296 0.372 0.325 0.424 #NUM! 2.321 0.375 #NUM! 0.376 0.243 0.315 0.631 1.247 0.479 0.208 0.018 0.507 #NUM! 1.480 -0.097 0.212 0.162 0.168 0.129 4.451 0.164 -0.611 -0.390 -1.529 -0.849 -0.075 #NUM! -0.875 #NUM! 0.719 0.500 -0.061 -0.400 #NUM! -0.260 #NUM! -0.574 #NUM! #NUM! #NUM! 0.124 0.595 0.496
1.245 0.494 0.343 0.372 0.967 0.591 1.524 #NUM! 0.264 0.541 -0.121 0.304 0.491 0.367 1.825 #NUM! #NUM! 0.021 -0.664 -0.273 0.479 0.146 0.249 0.338 0.149 -0.177 0.475 0.165 0.013 1.828 -0.061 0.112 0.579 0.171 0.677 0.221 -0.154 0.240 0.449 -0.206 1.051 -0.044 #NUM! 0.514 0.662 0.207 -0.042 -0.294 0.189 -0.083 -0.333
-0.471 -0.008 0.112 #NUM! 0.826 -0.950 #NUM! 0.109 0.176 -0.366 -1.151 0.173 0.298 -0.332 #NUM! 0.079 0.434 -0.323 0.481 0.221 0.251 0.199 -0.057 0.328 1.042 0.701 0.621 0.343 #NUM! 1.161 0.266 0.140 -2.838 0.589 -0.587 -0.087 -0.572 0.180 0.197 0.150 0.986 0.092 -0.030 0.201 #NUM! #NUM! -0.034 -0.697 0.270 1.914 0.281
#NUM! 0.258 0.736 -0.530 #NUM! -0.054 0.383 -0.104 0.471 0.100 0.496 -0.054 -0.141 -0.170 -0.281 0.254 #NUM! 0.562 -1.488 -0.313 1.069 0.334 0.358 #NUM! 0.220 0.522 -3.050 1.287 0.341 #NUM! -0.686 0.499 -2.221 #NUM! #NUM! 0.543 0.301 #NUM! 0.158 2.187 0.574 #NUM! 0.238 -0.277 0.836 -0.737 0.236 #NUM! -1.568 #NUM! 2.028
0.160 0.180 0.410 0.938 0.475 #NUM! -0.048 0.495 0.078 -0.452 0.731 0.684 0.215 0.439 -0.206 0.643 0.862 #NUM! 0.384 0.284 -0.664 0.114 0.217 0.220 0.268 0.162 0.418 0.121 0.608 -0.628 0.003 0.328 -0.077 -0.869 0.059 -1.245 0.395 #NUM! 0.501 0.325 0.509 0.250 0.521 0.149 0.275 0.706 -0.222 0.233 0.293 1.082 0.117
0.428 #NUM! -0.001 -0.271 1.098 -0.111 -0.271 0.860 0.216 #NUM! 0.105 0.513 1.142 0.213 0.105 0.588 0.599 0.472 -0.920 -0.565 0.417 0.452 0.508 0.056 #NUM! 0.277 0.578 0.209 1.309 1.751 0.286 0.882 0.395 -0.144 0.259 #NUM! 0.813 0.533 0.890 0.257 0.355 0.169 0.725 0.095 #NUM! 0.217 #NUM! 0.815 1.403 0.534 -0.635
1.130 0.328 0.899 0.399 1.320 #NUM! 0.671 1.812 0.337 #NUM! #NUM! #NUM! #NUM! 0.185 0.300 #NUM! 0.226 #NUM! 0.693 -0.121 0.281 -2.005 0.111 -0.516 0.478 #NUM! -0.987 0.064 #NUM! 0.308 -0.047 0.931 -0.151 0.185 0.673 0.310 #NUM! -0.831 0.196 0.605 #NUM! 0.423 -0.123 #NUM! 0.411 -0.539 0.497 -0.039 #NUM! -0.173 0.328
0.067 0.513 0.492 #NUM! -0.261 0.427 -0.153 0.325 0.131 -2.583 #NUM! #NUM! #NUM! #NUM! -0.020 0.253 -0.471 0.175 -0.242 0.655 0.217 -0.427 0.399 0.659 -0.293 0.844 #NUM! 0.134 0.340 0.220 0.440 0.221 0.248 -0.295 -0.036 0.443 #NUM! -0.166 #NUM! 0.008 -1.414 0.147 1.441 0.374 -0.526 0.205 -0.312 0.395 -0.015 0.326 #NUM!
0.758 #NUM! -1.137 #NUM! -0.042 -0.434 0.151 0.174 -0.149 #NUM! -0.003 -1.609 -0.408 -0.853 -0.163 0.017 0.171 0.125 0.415 0.151 0.066 0.066 0.585 -0.376 0.446 -0.319 0.316 0.186 0.517 -0.269 0.364 #NUM! 0.564 #NUM! 0.333 -0.390 0.590 -0.093 0.543 -0.883 -0.746 0.153 0.561 -0.231 -1.035 0.415 -0.145 -0.907 -0.075 -0.465 #NUM!
0.756 -0.013 0.291 0.900 0.670 0.490 1.666 0.850 #NUM! 0.689 -0.066 0.551 -0.069 0.062 -1.093 #NUM! 0.349 0.651 2.445 -0.856 1.808 0.409 #NUM! #NUM! 0.439 0.639 0.461 0.044 0.269 1.040 -0.188 -0.278 0.140 #NUM! -0.126 2.772 0.210 #NUM! -1.230 0.944 -0.040 -0.338 0.832 -0.094 -0.185 1.179 0.672 0.137 #NUM! -1.397 -2.838
-0.402 0.739 -0.428 0.474 #NUM! -0.249 -0.115 -0.294 -0.492 0.397 0.529 0.246 -1.412 #NUM! 0.552 1.624 0.044 -0.367 0.846 -0.066 0.396 0.452 0.426 0.149 0.615 #NUM! 0.827 -0.066 0.912 -1.520 -0.602 -1.028 #NUM! #NUM! #NUM! 0.897 -0.209 #NUM! -0.268 0.036 -0.785 -0.477 0.132 0.648 #NUM! 0.216 0.559 0.840 0.589 #NUM! 0.541
-0.505 -0.170 -0.252 0.558 -0.356 0.034 -0.455 0.470 -0.547 0.210 -0.060 0.733 -0.311 -1.458 -0.217 -0.809 0.414 -0.207 0.047 0.180 0.032 0.463 0.549 -0.600 #NUM! #NUM! -0.539 0.396 -1.123 0.504 0.133 1.295 -0.272 0.263 0.717 0.660 0.223 -0.214 -0.274 #NUM! -0.092 0.169 0.549 #NUM! #NUM! 0.378 0.118 0.083 0.281 -0.410 0.463
0.168 0.623 #NUM! 0.317 0.217 0.408 0.463 -1.098 1.338 0.203 -0.078 -0.076 -0.484 -1.701 #NUM! -2.506 0.105 0.981 0.985 #NUM! -0.166 -1.505 1.327 -0.270 -0.230 -0.190 -0.404 0.102 0.133 #NUM! 0.934 2.049 -0.586 0.011 -0.351 #NUM! 0.109 0.302 0.165 -0.176 0.138 -1.197 0.233 0.202 #NUM! 0.377 0.562 0.129 0.201 -0.321 -0.118
-0.697 0.401 0.163 0.104 0.481 -0.166 0.029 -0.084 0.748 0.055 -0.103 -0.967 -0.183 -0.880 -0.354 0.497 -0.823 -0.194 -0.248 0.315 -0.138 -0.180 -0.722 #NUM! 0.545 0.491 0.254 #NUM! 0.453 0.100 0.259 -0.052 -0.071 0.327 0.958 -0.503 1.037 -0.919 -1.641 -1.117 -0.056 -0.157 0.626 #NUM! -0.225 #NUM! #NUM! -0.759 -0.289 0.741 -0.363
0.502 #NUM! -0.306 -1.507 -0.314 -0.621 0.232 -1.676 #NUM! #NUM! 0.175 0.356 0.100 1.416 #NUM! 1.766 #NUM! 0.634 1.034 -0.133 -0.227 0.462 -0.528 0.492 1.303 0.078 0.180 -0.091 0.789 #NUM! -0.028 -0.285 -0.869 0.246 1.061 0.534 0.293 0.357 0.476 0.258 -0.019 -0.221 -0.125 -0.213 0.065 -0.026 0.311 0.307 0.363 -0.123 0.478
0.053 0.180 -0.253 -1.112 #NUM! -0.376 -0.319 1.127 0.242 0.468 1.283 0.339 #NUM! -0.301 -0.088 -0.610 #NUM! 0.629 1.200 #NUM! 0.062 0.143 -1.504 -0.301 0.057 0.066 0.757 -0.079 0.582 0.517 0.442 -0.078 #NUM! 0.412 0.298 0.064 -0.026 0.642 -0.169 0.121 0.430 -0.124 -0.066 0.100 0.562 0.343 0.320 0.310 0.419 0.751 0.546
0.307 1.102 0.637 0.008 0.932 1.153 0.678 0.391 0.656 0.806 0.076 -0.092 0.027 0.100 0.279 0.148 -0.530 0.242 0.044 0.218 0.545 0.410 -0.573 -0.021 #NUM! -0.097 0.452 0.220 0.171 0.209 -0.280 0.124 1.597 -0.016 0.399 0.809 0.213 0.895 -0.159 0.415 0.481 0.371 -0.037 -0.072 0.058 0.061 0.199 #NUM! 0.479 0.043 0.341
0.179 -0.719 0.168 0.256 -0.343 #NUM! -0.318 -0.495 1.170 0.094 -0.595 0.179 3.729 -0.517 -0.058 #NUM! -2.803 -0.890 0.191 #NUM! 0.223 0.272 0.228 0.170 0.639 0.554 0.353 0.817 #NUM! #NUM! 0.371 0.205 #NUM! 0.556 -0.685 0.441 0.178 -0.612 0.438 #NUM! 0.153 0.526 0.479 0.336 0.589 0.339 -0.290 -0.294 0.462 0.507 #NUM!
0.201 -0.288 0.076 0.571 0.491 -1.340 -0.253 -0.531 0.678 0.160 -0.763 -1.046 0.644 0.347 #NUM! -0.672 #NUM! 2.443 #NUM! -0.109 0.286 0.009 0.397 0.545 0.207 0.978 1.061 0.350 0.696 0.328 -1.239 0.632 0.585 -0.505 -0.043 -0.343 1.202 0.992 0.917 0.372 1.001 0.140 #NUM! 0.232 -0.448 -0.336 0.511 0.134 0.035 0.287 0.690
#NUM! -0.182 0.100 0.834 -0.010 #NUM! -1.247 -0.778 0.235 0.363 -0.319 #NUM! -0.538 #NUM! -0.079 -0.035 #NUM! #NUM! 0.058 0.441 0.153 0.043 #NUM! 0.967 -0.627 -0.324 0.091 0.751 0.071 2.193 0.149 0.108 0.344 1.476 -0.406 1.117 -0.597 0.117 0.935 #NUM! #NUM! 1.175 0.468 -0.242 0.193 1.111 2.305 0.718 1.030 -0.311 0.959
0.393 0.283 0.039 0.143 -0.110 0.783 0.388 -1.072 -0.118 0.341 -0.661 1.589 1.215 -0.336 0.547 0.263 -1.628 -0.447 0.316 0.663 0.704 0.618 0.219 0.835 -0.297 -0.280 0.182 0.205 0.301 0.057 -0.019 -0.294 0.059 0.414 #NUM! #NUM! #NUM! 0.363 -0.134 -0.455 #NUM! 0.184 1.062 0.081 0.230 1.045 0.209 -0.361 -0.338 #NUM! -0.477
-0.818 0.199 0.047 -0.370 #NUM! #NUM! 1.436 1.538 #NUM! 0.049 1.303 2.042 0.505 1.092 0.387 #NUM! -0.634 #NUM! 0.652 #NUM! -0.408 -0.057 -1.068 0.126 #NUM! -0.224 -0.627 -1.464 #NUM! 0.340 -1.013 -0.273 -0.354 -2.410 0.052 0.921 #NUM! -0.204 -1.731 -0.088 #NUM! 0.765 -0.143 0.124 0.201 0.486 -0.068 -0.751 -0.055 0.203 #NUM!
-0.589 0.359 #NUM! 0.198 0.473 1.383 -1.674 #NUM! -0.789 0.588 -0.227 #NUM! #NUM! -0.208 #NUM! #NUM! #NUM! #NUM! -0.925 0.102 #NUM! #NUM! -0.676 -1.811 0.149 0.309 0.445 #NUM! -0.678 #NUM! -0.508 -0.008 -0.648 -0.278 #NUM! -0.234 -0.491 #NUM! 0.439 -0.031 0.307 0.211 0.876 -0.581 1.453 0.066 0.492 -1.314 -0.474 0.201 0.347
1.199 -0.197 1.194 0.571 -0.316 -0.168 0.434 #NUM! #NUM! 0.100 -0.714 #NUM! 1.187 -0.390 0.426 0.816 #NUM! -0.003 -0.133 0.089 0.690 -0.336 0.301 -0.256 -0.931 0.185 0.335 0.031 1.091 -0.436 -1.642 #NUM! #NUM! -0.147 0.165 #NUM! -2.385 -0.675 0.219 0.074 0.099 0.766 0.034 1.101 0.502 0.583 1.164 0.134 -0.344 0.433 #NUM!
0.903 0.155 0.456 0.262 1.102 -0.112 -0.780 0.348 0.331 0.014 0.393 -0.181 0.285 1.031 0.277 0.278 -0.688 0.444 0.330 0.479 0.532 0.372 0.050 -0.385 -0.276 0.109 -0.616 0.730 -0.581 #NUM! -0.338 1.400 -0.096 0.458 -0.581 0.112 #NUM! -1.835 -0.372 #NUM! #NUM! #NUM! #NUM! #NUM! 0.797 0.380 0.116 -0.708 #NUM! 0.857 #NUM!
0.259 -0.600 -0.048 -0.420 -1.175 -0.370 2.780 #NUM! #NUM! 0.350 0.235 -0.500 0.196 -0.029 -0.598 0.018 -0.297 -0.110 1.652 0.342 0.897 0.347 0.780 0.031 0.490 0.383 -0.349 0.403 -0.334 #NUM! 0.244 -0.668 -0.312 0.462 #NUM! #NUM! -2.068 2.053 -0.535 0.642 #NUM! -0.148 -0.819 0.689 -0.316 #NUM! 0.572 1.577 0.191 1.047 0.244
0.363 -0.001 0.140 0.091 -0.043 0.263 0.192 0.586 2.111 0.165 #NUM! -0.174 -0.075 0.474 1.042 0.513 0.499 #NUM! -0.563 1.294 3.006 -1.317 1.120 -1.172 -2.531 0.499 -0.186 -0.807 0.453 0.201 #NUM! 1.054 #NUM! 0.329 1.897 0.818 0.295 -0.496 0.137 0.355 -0.014 -0.202 2.587 0.282 -0.373 0.242 0.146 -0.681 0.239 0.769 -1.339
0.402 -0.299 0.093 0.469 0.085 0.458 0.002 0.186 0.284 0.022 0.811 0.276 -0.211 0.323 #NUM! -0.307 -0.066 -0.915 1.359 0.261 1.163 -0.359 0.032 #NUM! 0.365 -0.238 1.113 -0.233 0.785 0.115 -1.223 0.475 0.344 -0.873 1.408 -0.342 1.207 #NUM! 0.243 -0.708 0.159 2.122 0.044 -0.406 -0.041 -0.205 0.659 -0.488 0.283 -0.163 -0.113
0.513 0.442 0.811 -0.290 1.831 0.288 -0.838 -0.017 0.899 -0.680 0.340 #NUM! 0.064 1.545 -0.068 0.448 0.278 0.419 0.554 #NUM! -2.252 0.583 0.442 #NUM! 0.020 -0.486 0.145 #NUM! 0.266 0.461 -0.132 #NUM! 0.081 0.274 0.358 -1.427 -0.247 -0.833 0.399 0.238 -0.965 -0.018 0.365 0.343 0.240 0.478 0.195 0.832 #NUM! 0.141 0.195
0.269 #NUM! #NUM! 0.104 0.030 0.434 0.400 #NUM! #NUM! 0.578 0.474 #NUM! 0.135 0.097 #NUM! -0.825 #NUM! 0.971 0.624 0.217 #NUM! 2.034 0.454 0.647 -0.441 -0.530 0.142 -0.382 1.217 0.379 0.283 1.912 -0.309 -0.065 #NUM! 0.849 -0.913 0.027 0.133 -1.046 0.484 -0.745 -0.534 -0.266 0.408 -0.967 0.200 0.163 -0.184 0.082 0.374
0.702 -0.021 -0.333 0.465 0.721 0.155 0.090 -0.215 0.165 0.046 #NUM! -0.605 -0.132 0.082 #NUM! 0.494 0.282 -0.808 0.235 -0.429 0.552 0.447 0.663 0.360 0.258 -0.227 #NUM! 0.337 -0.184 #NUM! -0.323 -0.039 -0.275 0.541 0.339 0.050 -0.323 0.103 0.267 0.328 -0.362 0.144 0.105 #NUM! 0.263 -0.149 0.575 0.305 0.208 -1.813 0.542
0.321 -0.022 0.645 -1.637 0.107 0.141 -0.241 #NUM! -0.228 -0.105 0.177 -0.672 -1.120 -0.050 0.648 1.395 0.647 -0.025 -0.063 -0.684 0.064 -0.336 -0.231 #NUM! -0.286 -2.095 #NUM! -0.409 #NUM! 0.436 0.261 0.081 0.475 1.125 0.257 0.173 -0.143 -0.169 0.397 0.381 #NUM! -0.776 0.066 0.625 0.550 0.197 0.589 0.066 0.754 -0.372 0.018
#NUM! 0.213 #NUM! 0.224 0.162 0.905 1.567 0.000 0.384 -0.697 #NUM! #NUM! #NUM! #NUM! -0.406 #NUM! -0.750 -0.838 0.027 -0.234 -0.253 0.189 -0.297 -0.177 #NUM! 0.474 0.483 0.282 -0.217 -0.089 0.102 0.361 -1.041 0.199 0.296 #NUM! 1.925 0.552 0.419 0.002 0.390 -0.191 -0.111 -0.232 0.275 #NUM! #NUM! -0.156 #NUM! 0.290 0.282
0.313 0.135 0.201 0.764 0.477 0.405 1.205 -0.458 -0.361 0.314 0.368 0.745 -0.242 1.670 0.587 #NUM! -0.496 0.401 #NUM! -0.240 -0.494 -0.138 -0.313 0.371 0.566 -1.233 0.024 -1.512 0.412 0.538 0.473 0.446 0.586 0.346 -0.582 0.286 0.363 0.228 0.028 -0.053 0.301 0.033 -0.066 0.669 0.060 0.041 0.151 0.071 0.349 0.269 0.603
-0.023 -0.305 0.237 0.632 #NUM! -0.591 0.962 #NUM! #NUM! -2.335 0.782 -0.369 0.365 1.049 -0.458 1.347 0.156 1.597 0.628 -0.337 -0.029 -0.037 #NUM! #NUM! #NUM! -1.084 #NUM! #NUM! 0.258 #NUM! -0.488 -0.678 -1.194 -2.468 -2.089 -2.838 -0.182 0.717 0.396 0.063 0.006 0.309 0.027 -0.598 0.435 0.638 0.835 #NUM! 0.192 0.151 0.078
-0.409 #NUM! 1.383 0.602 1.182 0.269 0.155 -2.207 -0.040 0.211 0.253 0.503 0.264 -0.390 0.253 -0.675 -0.125 0.064 0.170 -0.135 -0.276 0.239 0.415 0.257 0.215 0.217 0.382 -0.216 0.041 -0.464 -0.256 -0.514 0.181 2.385 0.360 -0.472 0.759 -0.164 -0.474 0.839 -0.888 #NUM! -0.071 -0.145 -0.463 0.311 -0.051 0.114 -0.235 -0.719 1.104
-0.091 0.155 0.510 -0.231 -0.098 -0.153 -0.053 #NUM! -0.364 1.056 0.302 0.368 -0.194 0.143 0.161 0.429 -0.004 0.327 0.262 -0.391 0.380 0.627 -0.196 -0.636 0.209 1.172 -0.138 -0.051 0.196 0.474 -0.250 0.248 -0.499 -0.221 0.631 -0.730 #NUM! 0.365 0.460 0.104 #NUM! #NUM! -0.065 -0.272 0.738 -0.179 0.683 #NUM! 1.215 -0.945 #NUM!
#NUM! 0.898 0.214 -1.101 -0.113 0.246 -1.285 0.455 0.356 0.397 -0.016 -0.352 #NUM! 0.484 0.414 0.081 0.147 0.443 -0.548 -0.088 0.027 0.191 0.120 -0.350 -1.926 0.199 0.345 -0.279 0.114 0.224 0.686 0.213 -0.284 0.504 0.260 0.370 #NUM! 0.511 0.594 1.037 -0.528 -0.117 0.110 -0.843 #NUM! #NUM! -0.201 0.830 -1.317 0.744 0.111
0.580 0.468 #NUM! -0.114 0.379 0.143 0.449 0.099 #NUM! 0.718 0.234 -0.570 #NUM! -1.724 -0.241 -0.134 0.862 0.297 -0.344 -0.387 -0.612 -1.534 -0.888 -0.050 #NUM! #NUM! 0.240 #NUM! 0.167 -0.111 #NUM! 0.169 0.262 0.443 -0.555 -0.487 0.127 -0.240 -0.781 #NUM! -1.359 -0.465 -0.146 0.065 0.228 0.587 #NUM! 0.106 0.579 0.519 0.005
2.289 0.391 0.735 0.023 -0.547 0.123 -0.447 -0.192 0.522 -0.976 -0.828 -0.094 -0.284 #NUM! 0.273 0.030 -0.274 0.000 0.527 0.389 0.747 #NUM! 1.004 -0.323 -0.186 -0.180 0.337 #NUM! -0.245 0.650 0.019 -0.032 0.991 -0.086 -0.002 -0.110 1.240 0.098 0.218 #NUM! #NUM! 0.610 -0.733 0.706 0.818 -0.452 -0.333 #NUM! 0.366 #NUM! 1.784
-0.476 0.638 0.698 #NUM! 0.186 -0.250 0.204 0.281 #NUM! 0.163 0.105 0.200 0.360 -0.035 0.931 0.607 0.725 0.330 0.388 0.026 0.252 #NUM! -0.202 0.028 -0.002 0.370 0.440 0.363 0.079 0.092 0.364 0.411 -0.574 #NUM! -0.328 #NUM! #NUM! 0.394 0.132 #NUM! 1.035 0.349 0.275 0.101 0.045 0.145 0.036 #NUM! 0.336 0.290 0.137
2.265 0.123 #NUM! -0.987 1.011 0.324 -0.030 -0.836 #NUM! -0.233 -0.026 -0.365 0.185 0.607 -0.828 0.018 0.293 -0.371 0.305 #NUM! -0.345 0.013 0.232 0.308 #NUM! #NUM! #NUM! 0.047 0.401 -0.700 -0.620 0.656 0.077 0.169 0.250 0.517 0.319 -1.300 0.151 0.695 0.121 0.534 0.062 0.356 0.916 #NUM! 0.028 0.654 0.293 0.582 0.401
0.940 -0.246 0.053 -0.307 0.482 0.376 0.484 0.437 -0.034 -0.452 #NUM! 0.659 0.424 0.404 0.422 0.096 0.186 -0.509 0.365 0.057 0.708 0.791 0.881 1.360 0.288 0.453 0.622 -0.469 #NUM! 0.339 -0.069 0.430 -0.478 -0.049 -0.665 0.541 0.546 1.313 0.487 #NUM! 0.146 -0.404 0.980 -0.567 #NUM! -0.689 -0.253 #NUM! -0.201 -0.950 0.093
0.152 -0.915 0.318 0.952 -0.420 -0.338 0.146 -0.526 1.078 0.733 0.431 0.574 -0.622 0.074 1.336 #NUM! -0.044 -0.506 -0.085 0.387 #NUM! -0.540 -0.123 0.072 #NUM! #NUM! -0.143 -0.407 0.580 #NUM! 0.205 0.507 0.575 0.671 -0.002 0.523 0.456 -0.150 0.136 0.357 0.132 0.339 #NUM! 0.613 0.066 #NUM! -0.148 0.832 -0.066 -0.179 0.296
0.026 0.311 0.654 0.126 0.204 -0.255 -0.277 0.713 0.353 1.759 0.577 0.409 0.004 -0.354 -0.340 -0.063 -0.108 0.351 -0.130 #NUM! 0.003 -0.051 #NUM! -1.140 1.151 -0.059 #NUM! 0.337 -0.024 0.457 -0.137 1.036 0.336 -0.590 -0.762 0.657 0.542 0.312 0.471 -0.226 0.147 -0.869 -0.130 0.359 0.094 -0.080 -0.133 0.405 0.848 -1.968 -0.559
1.545 #NUM! #NUM! -0.224 0.000 -1.270 0.012 0.293 #NUM! #NUM! #NUM! 0.044 0.340 0.231 0.141 0.439 1.183 0.325 0.363 #NUM! -0.261 0.493 -1.099 #NUM! #NUM! 0.029 -0.345 -0.494 #NUM! #NUM! 0.114 -0.104 0.516 0.328 -1.469 1.213 -0.211 0.496 0.961 0.106 -0.897 #NUM! 0.220 1.622 #NUM! 0.123 0.183 0.393 0.364 0.715 0.379
-0.238 0.379 -0.127 -0.081 0.578 1.878 0.183 0.143 -0.049 -0.232 0.188 0.042 0.237 -0.314 -0.825 0.984 -0.561 0.331 0.653 0.629 0.389 0.735 1.053 0.772 0.339 0.216 0.273 0.469 0.739 0.689 0.843 0.737 0.275 0.664 #NUM! 0.258 0.257 0.109 -0.157 #NUM! -0.068 0.479 -0.471 -0.574 0.446 0.392 -0.158 0.398 #NUM! #NUM! 0.234
#NUM! 1.196 -0.065 -0.973 -0.247 0.445 0.624 0.208 0.256 -1.137 -0.405 -0.066 0.980 -0.957 -0.478 -0.285 #NUM! -0.324 #NUM! 0.268 1.005 0.083 0.248 0.227 -0.320 0.478 #NUM! -0.269 0.139 -0.559 0.390 -0.240 0.331 0.808 0.582 -0.254 -0.407 -0.127 #NUM! #NUM! #NUM! 0.153 0.354 0.199 0.520 -0.054 0.054 0.600 -0.759 0.179 -0.089
-1.014 0.620 0.545 #NUM! 2.972 2.747 0.867 0.704 -0.747 0.276 #NUM! -1.405 -0.091 -0.261 0.904 -0.402 0.787 #NUM! 0.301 #NUM! -0.912 -0.178 0.135 -0.198 -0.210 -0.091 0.379 #NUM! 0.150 -0.292 1.771 0.178 0.383 0.531 -0.135 0.569 0.168 0.036 -0.159 1.194 1.886 -0.855 -0.669 -0.677 0.230 #NUM! 0.458 -0.068 #NUM! -0.038 0.199
0.009 #NUM! 0.193 -0.026 0.822 0.490 -1.276 -1.238 -0.787 0.001 -0.097 0.592 0.613 -1.117 -0.630 -0.041 1.238 0.287 0.049 0.679 0.277 0.575 0.664 0.014 0.325 0.960 0.650 -1.095 #NUM! 0.924 0.725 -0.189 0.720 -0.079 0.450 0.141 0.332 #NUM! 0.038 0.203 #NUM! -0.531 #NUM! #NUM! #NUM! 0.170 0.060 -0.052 0.235 0.232 -0.806
0.638 0.038 -0.056 0.560 -0.131 0.244 #NUM! 0.472 #NUM! #NUM! 0.054 0.153 -0.011 0.405 0.305 1.039 0.616 -0.303 #NUM! 0.292 -0.517 -0.076 -0.067 -0.857 0.756 -0.279 #NUM! 0.012 0.137 0.441 2.700 0.705 -0.139 0.290 0.197 #NUM! -0.413 0.161 0.251 0.426 -0.667 #NUM! -0.178 #NUM! 1.060 -0.192 -0.070 0.206 0.468 0.415 0.227
1.216 -0.439 0.392 -0.157 #NUM! 0.756 -0.220 -0.481 #NUM! -0.126 -1.082 0.246 -0.161 -1.195 1.607 0.098 -0.025 -0.021 0.137 #NUM! -1.009 -2.019 0.261 -0.225 0.433 -0.520 -0.032 0.175 1.053 -0.578 0.354 -0.275 -0.057 -0.066 0.372 0.345 0.353 -0.156 0.301 -0.080 -0.017 0.209 0.032 0.198 0.088 -0.116 1.107 #NUM! -0.279 0.358 0.323
-0.021 0.418 0.612 0.349 0.372 0.205 0.442 -0.540 -0.760 0.286 0.119 #NUM! 0.489 -0.345 0.599 -1.124 #NUM! 0.013 #NUM! -0.179 0.436 -0.350 #NUM! #NUM! 0.702 -0.006 -0.165 0.428 0.629 -0.104 0.603 0.099 1.032 #NUM! 0.241 0.897 0.215 0.541 #NUM! #NUM! -0.438 1.881 0.313 -0.098 0.316 0.248 -0.310 0.407 0.390 -0.030 1.705
0.414 0.071 0.532 0.856 1.615 0.156 0.407 -0.246 0.942 0.868 0.474 0.422 0.176 -0.091 -0.194 -0.122 #NUM! #NUM! -0.530 #NUM! #NUM! #NUM! 0.008 #NUM! -0.232 #NUM! -0.795 -1.162 0.161 -0.323 -0.007 0.173 0.298 0.331 -0.646 -0.050 0.224 -0.889 0.742 -0.445 0.250 0.739 #NUM! 0.387 0.465 -0.540 0.512 0.706 -0.220 -0.346 0.306
0.311 0.462 -0.073 0.333 #NUM! -0.054 0.342 -0.445 #NUM! -1.423 #NUM! 0.133 -0.011 -0.288 0.554 0.106 0.290 0.119 0.021 1.428 -1.504 -1.286 1.185 0.008 0.672 -0.173 1.082 0.045 -0.152 -0.814 -0.249 #NUM! #NUM! #NUM! #NUM! 0.582 0.594 0.050 -1.337 -0.746 -0.164 0.285 -0.311 #NUM! -0.244 -0.504 0.371 0.467 -0.221 -2.021 #NUM!
0.075 0.703 2.528 0.194 #NUM! -0.361 -1.224 #NUM! -0.396 #NUM! 0.284 0.195 -0.884 0.974 -0.520 -0.602 0.765 0.870 0.925 -0.102 0.241 #NUM! 0.341 0.837 0.078 0.911 -0.168 -0.353 0.220 0.432 1.368 0.606 4.653 0.131 -0.036 -0.787 -0.504 0.563 0.764 -0.382 0.252 0.035 -0.637 0.234 0.205 0.671 -0.007 -0.479 -0.502 0.323 0.196
#NUM! 0.290 #NUM! -1.246 -0.334 0.373 0.676 0.501 #NUM! -1.962 -0.155 -0.038 0.212 #NUM! -0.077 -0.285 -1.729 2.177 -0.274 0.427 1.520 0.909 0.435 0.098 #NUM! 0.776 -0.998 -0.216 0.774 -0.354 0.067 0.369 1.038 0.435 0.793 0.925 0.504 0.408 -1.567 0.251 0.717 0.379 0.707 0.722 0.683 0.823 0.035 0.467 0.306 1.257 0.714
-0.163 0.294 0.324 0.379 0.323 0.090 #NUM! -0.078 #NUM! 0.437 0.268 -0.946 0.931 0.213 0.362 -0.247 #NUM! 1.147 0.003 -0.625 #NUM! 0.146 -0.012 0.064 -0.781 -1.674 -0.198 -0.115 0.165 #NUM! -2.135 0.253 0.922 0.162 -0.008 0.679 0.114 #NUM! 0.065 #NUM! -0.384 0.342 -1.001 -0.894 -0.781 0.723 0.610 -0.387 -0.105 0.061 0.456
-0.430 -0.129 -0.463 0.003 0.373 #NUM! 0.303 -0.106 -1.150 -0.755 #NUM! -0.050 0.438 0.524 0.440 0.821 0.541 0.393 0.271 0.270 0.707 0.334 0.615 0.252 0.586 0.551 0.846 -0.040 0.398 0.756 0.810 #NUM! 0.482 -0.263 0.370 -0.092 0.746 -1.868 1.152 2.373 0.317 #NUM! #NUM! -0.343 -0.650 #NUM! 0.344 -0.166 0.316 #NUM! -1.535
-1.795 #NUM! 0.109 #NUM! 0.180 -0.374 -1.825 #NUM! 0.004 0.319 #NUM! -0.239 0.958 -0.022 0.263 -0.410 0.310 -0.357 -0.383 0.207 -0.140 -2.346 #NUM! -0.662 #NUM! -0.014 0.122 #NUM! #NUM! -0.309 -0.152 0.597 #NUM! 0.524 #NUM! 0.275 -0.210 0.451 0.319 0.442 -0.635 1.001 -0.510 -3.364 -0.382 0.217 0.585 #NUM! 0.052 0.558 0.129
0.155 -0.394 0.210 -0.243 #NUM! 0.556 -0.490 -1.051 -1.041 -0.162 2.179 0.495 0.163 -0.345 0.239 0.299 -0.841 -0.606 #NUM! 2.621 #NUM! -0.039 -0.449 #NUM! -0.202 -0.122 -0.016 0.199 0.275 1.740 1.068 0.260 1.825 0.154 0.689 -0.608 0.643 #NUM! -1.020 -1.145 -0.280 0.148 -0.090 0.265 0.546 -0.004 -0.082 0.165 1.469 #NUM! -0.301
#NUM! -0.264 0.986 #NUM! -0.096 0.178 0.107 -0.349 -0.039 0.716 0.018 0.256 0.286 -1.649 0.148 0.567 -1.322 1.037 -0.703 0.911 0.171 0.048 0.223 -0.891 0.876 0.514 0.053 #NUM! 0.280 -0.657 #NUM! 0.746 0.883 -0.415 #NUM! 0.250 0.040 0.950 0.045 -0.123 0.192 0.776 0.409 0.186 0.228 0.139 #NUM! -1.345 -0.002 -0.097 0.664
0.335 0.316 0.488 0.006 #NUM! 0.146 1.881 #NUM! 1.907 0.282 -0.386 -0.179 0.072 #NUM! -0.184 0.241 0.011 0.594 -1.293 0.277 0.131 -0.259 -0.774 0.498 0.218 0.454 0.096 -0.814 0.530 #NUM! -0.641 -0.098 0.187 -0.334 -0.560 0.464 -0.370 0.351 0.222 -0.852 1.619 0.605 #NUM! -1.545 0.029 0.159 0.064 0.565 0.413 0.257 0.427
-0.120 1.137 0.452 0.426 0.448 0.520 0.209 0.401 0.595 0.510 0.323 0.828 -0.160 1.263 0.263 0.257 #NUM! 0.274 0.372 #NUM! #NUM! 0.501 -0.191 #NUM! -1.220 #NUM! -0.164 -3.090 -0.872 0.140 -1.846 #NUM! #NUM! 0.650 0.250 0.598 0.477 -0.266 -0.282 #NUM! 0.476 0.410 -0.296 -0.097 0.313 0.017 0.333 0.381 2.787 0.760 -0.394
0.301 0.199 -0.389 0.283 -0.246 0.155 1.091 0.435 2.485 0.220 0.320 0.922 0.336 #NUM! 0.869 0.528 #NUM! 0.641 0.173 0.556 1.201 0.231 0.201 0.159 0.314 0.056 0.095 0.228 -0.347 -0.226 -0.404 0.519 0.486 0.120 0.103 #NUM! 0.181 0.097 0.244 0.715 0.659 0.320 0.287 0.125 0.572 0.407 0.082 -0.073 0.984 0.060 #NUM!
1.855 #NUM! 0.310 0.408 -0.209 0.480 0.476 -1.929 0.345 #NUM! 0.282 0.019 -0.288 0.929 -0.024 0.325 0.213 0.158 -0.414 -0.961 0.718 0.137 -0.283 0.025 -0.824 0.299 0.393 0.515 0.351 0.187 0.322 0.092 0.209 0.178 0.621 0.152 1.122 0.994 -0.015 0.907 0.894 -0.385 1.944 0.420 0.461 -0.147 0.500 4.112 -0.891 -0.628 0.516
0.342 0.657 -1.642 0.380 0.082 0.523 0.340 3.072 0.125 0.298 0.300 0.012 -0.505 0.222 -0.141 0.610 -0.263 0.332 -0.196 -0.326 #NUM! -0.022 0.363 -0.193 -0.031 #NUM! -0.735 2.203 0.476 0.386 0.124 -0.174 -0.387 0.006 -0.089 0.118 0.547 0.721 -0.130 1.347 2.040 -0.510 -0.360 0.329 0.213 0.290 -0.366 0.028 0.423 -0.542 0.277 0.161
0.191 0.028 0.680 0.133 0.063 -0.070 0.331 0.053 -0.983 0.734 0.358 0.407 0.828 0.299 -0.014 0.068 0.234 0.650 0.002 -0.298 -0.023 0.178 1.746 0.353 0.204 -0.081 -0.027 -0.150 0.612 -0.178 0.546 2.609 0.587 -0.062 0.103 0.052 -0.881 0.753 -0.452 -0.430 1.215 0.879 -1.058 0.215 2.118 0.027 0.531 -0.006 0.308 0.180 #NUM!
4.044 0.469 0.247 0.400 0.842 0.096 0.350 0.405 0.263 0.200 0.283 0.426 -0.119 0.319 0.762 0.957 0.292 0.850 0.278 -0.144 -0.263 0.735 -0.843 0.729 0.180 0.371 0.391 0.763 0.223 0.630 0.521 0.077 0.222 0.999 0.719 -0.792 -0.202 -0.233 0.580 #NUM! -0.379 -0.240 -0.241 -0.270 -1.321 0.465 -0.081 -1.123 0.167 0.687 0.530
0.643 -0.127 -0.480 0.664 -3.396 0.511 1.202 0.893 0.110 -0.203 0.514 -1.448 #NUM! 2.575 2.533 -0.388 0.629 0.082 0.076 -0.983 -0.983 -0.462 #NUM! 0.117 -0.665 -0.230 -0.461 #NUM! #NUM! -0.981 1.038 #NUM! -2.136 -0.725 0.599 #NUM! -2.507 0.400 0.034 0.102 -0.203 0.229 #NUM! -0.491 -2.480 -0.640 0.346 -0.157 0.134 0.392 -0.084
-0.070 0.126 -0.164 0.344 -0.147 0.759 -0.879 #NUM! 2.904 0.346 -0.048 0.275 #NUM! 0.499 -0.573 0.190 0.409 #NUM! 0.554 0.121 -0.867 #NUM! -0.674 #NUM! 0.574 -0.189 0.467 -0.127 #NUM! 0.094 #NUM! -0.542 0.563 #NUM! 0.037 -0.565 0.201 1.412 0.322 0.288 -0.918 0.308 #NUM! -0.007 0.048 -0.214 -0.266 0.841 #NUM! 0.148 0.482
-0.667 0.601 0.178 0.145 0.913 -0.008 0.102 -0.308 0.568 #NUM! #NUM! 1.332 0.509 #NUM! 0.253 1.565 0.358 0.016 0.059 #NUM! -0.639 0.121 -0.277 #NUM! #NUM! #NUM! -1.345 #NUM! 0.146 -0.212 0.575 -0.604 -0.337 #NUM! 0.284 -0.047 1.212 0.028 0.191 -0.249 0.230 0.618 -0.071 0.156 0.733 #NUM! #NUM! 0.466 0.569 0.855 #NUM!
-0.403 -0.175 0.337 0.157 0.457 0.635 0.452 0.024 0.633 0.945 2.408 1.717 0.934 0.615 0.077 0.451 -0.308 0.600 -0.720 0.939 0.871 0.027 0.339 -0.516 -0.421 -0.303 0.855 0.584 0.470 -0.117 #NUM! -0.641 0.330 0.249 0.003 0.015 0.154 -0.353 0.266 0.416 0.446 0.167 0.115 0.452 -0.149 1.104 0.496 -0.082 0.792 0.489 0.081 0.236
0.569 -0.943 -0.001 0.531 -0.391 0.014 0.322 0.233 0.642 0.206 0.655 0.424 0.019 0.528 -0.040 0.467 -0.185 #NUM! 0.794 0.421 0.168 #NUM! -0.125 -0.325 0.850 0.013 0.434 0.125 #NUM! -0.408 0.024 0.120 -0.695 -0.094 0.540 -0.273 0.733 -0.208 0.352 -0.065 -0.078 -0.271 -0.848 0.815 -0.589 0.375 0.277 3.041 0.490 1.736 0.217 0.215
0.084 0.353 0.708 1.426 -0.636 0.457 #NUM! 0.570 1.550 0.297 0.388 0.263 -0.762 0.258 0.067 #NUM! 0.220 0.437 #NUM! #NUM! -1.499 1.015 0.231 #NUM! 0.425 #NUM! -0.513 0.091 0.116 0.626 0.214 0.266 0.409 0.546 -0.336 0.162 0.727 0.103 -0.557 1.618 -0.170 0.198 1.328 0.741 -0.224 -0.181 0.062 0.725 #NUM! #NUM! -2.309
-0.347 #NUM! #NUM! 0.410 #NUM! -1.680 -0.232 #NUM! #NUM! 1.282 -0.431 -0.227 -0.064 -0.106 -0.343 0.288 #NUM! 0.741 0.017 0.167 0.445 0.138 0.187 -0.401 0.556 -0.267 -0.096 0.278 0.930 -0.345 0.001 0.334 0.133 0.459 -0.029 -0.845 #NUM! 0.440 -0.298 0.505 #NUM! 0.121 0.178 0.649 1.092 0.604 0.268 1.007 1.146 0.888 0.321
-1.851 #NUM! 0.434 0.196 0.152 -0.988 -0.364 -0.848 0.261 #NUM! 0.085 0.194 0.149 0.418 0.264 0.026 -0.663 0.105 #NUM! 0.053 1.102 #NUM! 2.417 -0.189 -0.579 0.555 -0.026 1.043 0.119 -0.073 -0.344 0.002 -0.067 0.401 0.058 2.602 0.085 0.307 -0.032 -0.724 0.430 0.211 #NUM! 0.032 0.705 -1.433 0.304 0.125 0.188 0.506 0.140
#NUM! -0.119 0.001 0.607 -0.340 0.298 0.084 0.028 -0.490 1.019 -0.282 0.582 -0.135 -0.094 0.118 -0.236 0.177 -0.044 #NUM! 0.524 -0.105 0.098 -0.406 0.533 #NUM! -0.732 -0.570 0.034 0.822 -0.161 #NUM! 0.197 -0.301 0.860 0.136 -0.599 -0.599 -0.408 0.023 0.101 0.167 0.311 0.455 0.194 -0.155 0.037 0.103 0.194 0.588 0.529 0.035
0.327 0.688 0.425 0.348 -0.089 -0.371 #NUM! -0.494 -0.249 0.220 0.484 0.124 #NUM! 0.215 0.451 0.436 0.305 1.478 0.056 0.297 2.124 0.172 -0.010 -0.580 -0.014 -0.727 -0.158 -0.451 #NUM! 0.619 -0.059 0.067 -0.161 #NUM! 0.085 0.856 -0.731 -0.947 -0.351 0.766 -0.522 -0.088 0.256 0.049 0.272 0.026 0.577 -0.154 0.526 -0.648 0.436
-0.172 -0.263 0.287 -0.030 0.289 0.688 #NUM! -0.666 0.660 0.138 -1.046 #NUM! -0.100 0.751 #NUM! 0.430 -1.009 -1.729 #NUM! 0.725 -0.019 0.141 0.875 0.719 0.567 0.680 #NUM! 0.780 0.269 0.189 -0.432 0.768 #NUM! 0.147 0.609 0.107 0.149 -0.255 0.649 -0.085 -1.798 #NUM! 0.384 -0.180 -0.529 0.167 0.198 -0.081 -0.287 0.266 0.318
0.438 0.341 -0.119 0.659 0.211 0.215 0.319 0.089 0.306 -0.030 0.418 0.238 0.530 0.660 0.345 -0.165 -0.463 0.057 -0.384 #NUM! 0.541 0.551 -4.262 0.278 0.202 0.410 -1.561 0.403 0.422 0.952 -0.203 #NUM! 0.388 0.147 0.213 0.305 0.254 0.676 -0.001 -0.329 -0.172 -1.106 0.335 0.881 -0.003 1.935 0.133 -0.377 #NUM! 0.628 -0.435
-0.081 #NUM! 2.314 -0.036 4.263 0.233 #NUM! 0.466 0.313 -0.420 0.501 0.572 0.400 0.638 #NUM! 0.280 #NUM! 0.648 0.236 #NUM! 0.163 #NUM! #NUM! -1.771 -0.393 #NUM! -0.138 -0.096 -1.644 -0.138 -1.064 0.425 0.258 #NUM! -2.133 0.264 0.625 0.481 #NUM! -0.154 0.365 0.127 0.250 0.897 0.287 0.512 0.899 0.329 0.232 -1.539 -0.354
0.148 -0.953 0.390 0.037 -0.046 0.051 0.738 0.200 -0.817 0.413 0.402 0.238 -0.409 0.503 -0.022 -0.007 0.499 #NUM! 0.293 -0.034 #NUM! -0.251 #NUM! -0.317 0.152 0.124 0.688 1.223 0.576 0.962 0.178 0.189 0.303 -0.029 0.143 0.042 #NUM! 3.182 0.371 0.890 0.495 0.445 0.764 -0.316 -1.338 -0.082 0.639 0.870 0.090 0.566 0.014
0.347 -0.537 0.084 2.578 1.466 -0.156 -0.052 0.331 0.449 0.712 0.712 0.122 0.316 -2.330 0.270 0.673 1.771 -0.123 0.145 0.234 -0.318 -0.719 -0.084 1.047 #NUM! -0.100 -0.841 -1.265 0.596 0.523 -0.155 1.220 0.274 -0.132 0.169 -0.074 -0.128 0.389 -1.362 0.238 -0.067 0.073 0.068 -0.369 -2.916 0.540 1.924 #NUM! 0.551 0.130 -0.059
#NUM! -0.202 0.770 0.568 0.534 0.060 1.819 0.086 -0.434 -0.068 #NUM! #NUM! -0.864 0.957 0.115 0.042 0.155 0.358 -0.485 0.366 0.425 0.738 -0.913 #NUM! -0.184 0.669 0.892 -0.056 -0.579 0.494 #NUM! 1.037 -0.138 0.792 0.937 1.241 -0.465 1.773 0.055 #NUM! -1.143 1.644 0.542 -0.388 #NUM! 0.359 -0.590 #NUM! 0.418 0.701 #NUM!
0.848 2.221 2.490 0.614 0.317 -0.271 1.154 1.301 -0.805 0.907 0.303 0.636 0.500 0.193 -0.093 0.996 0.067 -0.315 0.184 0.019 0.715 0.183 0.108 0.124 0.317 0.474 #NUM! -0.086 -0.608 0.137 #NUM! -0.039 0.146 -0.618 1.160 0.396 0.168 0.438 -0.274 -0.766 0.253 0.477 0.316 0.500 -0.251 0.401 -3.233 0.096 -0.429 #NUM! 0.677
0.759 -0.821 0.021 0.365 0.373 1.140 0.122 #NUM! #NUM! -0.040 -0.116 -0.372 -0.133 #NUM! -0.960 0.794 -0.097 0.540 0.039 0.052 0.217 0.379 0.208 -0.349 0.927 -0.941 #NUM! -0.749 1.144 -0.343 0.322 0.480 -0.536 0.189 -0.170 -0.341 -0.062 #NUM! 0.288 0.306 -0.099 0.451 0.173 -0.478 -0.191 #NUM! -0.319 0.280 0.361 0.164 -0.129
-0.070 -0.239 0.800 0.178 1.597 -1.438 -0.121 -0.219 0.785 0.466 1.310 -0.471 -1.693 #NUM! 0.777 0.909 0.035 0.641 0.142 -0.150 -0.489 -0.484 1.119 -0.373 1.595 0.402 0.101 #NUM! 0.045 0.823 -1.148 -0.650 #NUM! #NUM! #NUM! 0.396 0.263 -0.350 -0.156 0.222 #NUM! -0.189 -0.225 0.022 -0.160 -0.277 -0.418 0.429 1.205 -0.444 0.200
-0.345 #NUM! -0.183 #NUM! #NUM! 0.287 -0.275 0.004 0.314 0.161 -0.068 #NUM! -0.263 0.217 -0.906 0.038 0.030 -0.378 -0.013 0.180 0.166 0.628 -0.998 -0.594 0.564 0.002 0.216 0.596 0.275 0.206 2.203 -2.242 0.420 0.343 0.253 0.391 0.253 0.573 -0.255 0.517 -0.428 -1.948 0.116 -0.673 #NUM! 0.111 -0.119 #NUM! -0.041 0.985 -0.030
-0.041 -0.257 -0.305 0.295 0.167 #NUM! 1.050 0.624 0.542 0.162 0.305 -0.142 0.254 0.274 #NUM! -0.509 -0.195 -0.052 -0.154 0.109 -0.376 -0.362 -0.293 0.391 -0.501 -0.144 0.783 -0.214 0.211 -0.152 -0.967 0.206 0.493 0.952 -0.034 #NUM! 0.088 0.133 0.306 -0.177 0.045 0.477 0.025 0.295 0.383 0.335 0.517 -0.658 0.067 0.474 0.264
-0.461 -0.254 0.624 -1.248 0.034 #NUM! -0.686 0.387 0.328 #NUM! -0.449 #NUM! 0.625 #NUM! #NUM! #NUM! #NUM! -1.098 -1.004 -2.582 0.128 -1.058 0.248 0.226 -1.070 #NUM! 0.291 -2.004 #NUM! #NUM! #NUM! #NUM! #NUM! #NUM! -0.270 #NUM! #NUM! -0.175 #NUM! -2.191 -0.073 0.057 #NUM! #NUM! 1.444 #NUM! #NUM! -1.014 -0.583 0.569 #NUM!
4.042 0.229 0.854 -0.164 0.011 0.139 0.332 0.741 0.232 -0.359 -0.160 -0.493 0.118 0.281 -0.218 0.364 #NUM! #NUM! -0.358 -1.473 -0.250 -0.030 0.172 -0.013 #NUM! 0.527 1.267 0.289 #NUM! -0.419 0.325 0.395 0.099 0.147 0.320 0.372 0.226 0.088 0.184 0.221 0.477 0.286 0.789 -0.099 0.650 0.109 #NUM! 1.503 0.483 0.218 0.093
#NUM! -2.275 0.074 0.163 0.248 -0.278 -0.406 0.374 0.995 0.300 2.598 -1.100 -0.105 -0.065 #NUM! -0.230 0.111 0.295 0.059 0.477 0.929 0.213 0.469 0.074 0.446 0.152 0.068 0.106 3.793 -0.113 -1.189 #NUM! -0.023 1.145 0.060 -0.014 0.241 -0.019 0.455 0.551 0.068 0.599 -0.254 0.296 1.160 0.093 #NUM! #NUM! 0.408 -0.321 0.794
0.104 0.155 0.043 0.188 -0.503 0.446 0.150 #NUM! -0.064 0.621 0.401 0.469 0.545 -0.231 0.244 1.145 1.748 0.137 0.241 0.158 -0.219 0.275 #NUM! #NUM! #NUM! 0.208 0.713 -0.105 0.275 0.220 0.283 -2.285 0.448 0.749 0.246 0.369 #NUM! 0.117 0.169 -0.162 -0.077 #NUM! -0.259 -1.071 -0.043 0.532 -0.689 0.379 0.021 1.193 1.213
-0.877 0.432 1.102 -0.110 0.398 0.387 0.213 -0.051 1.038 -0.164 0.000 0.340 0.453 0.374 0.805 0.302 0.294 0.370 0.305 0.441 0.538 -0.716 -0.199 0.076 -0.631 -2.290 -0.077 0.300 0.002 2.340 0.355 1.688 0.191 #NUM! #NUM! 0.575 0.717 -1.368 -0.386 #NUM! -0.115 -0.309 0.442 -0.929 -0.072 0.218 0.306 0.154 -0.010 0.087 0.165
#NUM! -0.254 0.184 #NUM! -0.704 #NUM! 0.230 -0.732 #NUM! 0.189 0.812 -0.167 -0.105 0.939 1.357 0.519 0.504 -0.264 0.161 -0.113 #NUM! #NUM! #NUM! -0.616 0.358 -0.338 0.164 0.097 #NUM! 0.150 -1.459 #NUM! -0.479 1.308 -0.589 0.332 0.191 0.706 -0.729 #NUM! -1.084 -0.201 #NUM! -0.461 -0.745 0.158 0.338 -0.042 -0.932 0.081 -1.008
-0.285 0.166 0.002 -0.231 0.833 0.022 0.534 0.115 -0.514 -0.354 -0.085 0.312 -0.222 0.349 #NUM! 0.350 -0.041 -0.018 0.201 -0.170 0.109 #NUM! -0.288 -0.137 0.170 -0.053 0.854 #NUM! 0.730 -0.926 #NUM! -1.487 #NUM! #NUM! -0.386 #NUM! #NUM! 1.252 -0.451 #NUM! -0.240 -0.110 0.597 0.178 0.144 0.009 0.245 -0.038 -0.084 1.570 0.447
0.160 0.279 -0.253 -0.290 #NUM! 0.839 #NUM! 0.016 -0.251 0.509 -0.351 #NUM! -0.741 #NUM! 0.136 -0.562 0.150 0.602 0.265 0.866 -0.198 -0.111 -0.790 -0.033 -0.143 -0.389 -0.360 -0.138 0.345 #NUM! 0.098 0.118 0.395 0.145 -0.316 0.373 -0.023 0.480 -0.622 -0.265 -0.455 #NUM! 0.524 -0.961 0.435 0.406 -0.047 0.108 #NUM! -2.245 -1.269
-0.829 0.599 0.384 0.549 -0.190 -0.036 -0.429 0.520 0.442 #NUM! 0.013 -0.522 0.433 -0.016 2.438 0.468 -0.751 -0.234 #NUM! #NUM! -0.133 -0.546 -0.523 -0.704 -0.100 #NUM! #NUM! 0.211 0.788 1.253 0.012 -0.119 -1.476 0.073 #NUM! -0.744 -0.200 -2.171 -0.060 -0.517 0.205 -0.088 0.440 0.271 -0.364 1.049 #NUM! #NUM! 0.279 0.088 0.357
0.169 0.784 0.527 0.288 0.194 0.273 -0.514 -0.063 0.447 -0.738 -0.456 -0.252 0.506 -0.043 0.310 0.278 0.400 0.528 0.176 #NUM! -0.106 0.088 0.801 0.314 -0.229 0.087 -0.016 0.905 -1.005 0.345 0.113 0.197 0.035 0.056 -1.106 1.385 -0.455 0.283 0.045 0.422 0.284 0.153 0.165 #NUM! 1.726 0.111 -0.516 0.156 0.569 #NUM! #NUM!
-0.253 1.056 0.695 #NUM! #NUM! 0.950 0.139 0.290 1.161 0.269 -0.645 0.251 0.018 0.266 #NUM! -0.384 -0.117 0.026 0.053 -0.188 -0.396 0.845 0.031 #NUM! #NUM! -0.057 0.585 0.098 0.267 -0.612 0.142 -0.294 1.453 #NUM! 0.023 0.461 -0.366 0.310 -0.380 -0.098 -0.420 0.263 0.251 -0.472 #NUM! 0.301 0.241 -0.167 -0.085 0.297 0.324
0.130 0.951 0.169 0.178 -0.446 -0.312 1.425 0.252 0.200 -0.625 -1.286 -0.828 -0.081 #NUM! -0.141 -0.032 #NUM! 0.548 0.192 -0.090 0.370 0.185 1.178 1.958 -0.951 -0.173 #NUM! 0.202 0.546 0.273 0.341 -0.050 -0.015 -0.111 1.081 0.318 -0.046 0.547 0.412 #NUM! #NUM! 0.450 -0.499 0.556 0.221 0.301 -0.393 0.551 0.315 0.722 0.123
0.486 #NUM! -2.556 0.391 0.271 -1.221 0.816 #NUM! 0.685 -0.393 1.927 0.639 0.406 0.165 0.346 0.492 0.330 -1.400 -1.501 0.662 -0.496 0.540 #NUM! 0.505 1.496 0.371 #NUM! -1.015 #NUM! #NUM! -0.505 0.325 -0.570 #NUM! #NUM! #NUM! #NUM! -0.101 0.786 0.696 0.431 -0.094 -0.109 -0.012 #NUM! #NUM! -0.452 -0.924 0.125 -0.193 1.053
0.494 0.668 0.258 0.429 0.229 0.090 0.395 2.425 #NUM! 0.233 0.322 2.440 -0.326 0.214 0.383 -0.051 0.363 -0.091 0.250 #NUM! 0.489 0.021 -0.243 0.077 0.241 0.432 -0.026 -0.252 0.080 0.332 #NUM! 0.372 0.022 #NUM! -3.756 1.009 #NUM! 0.735 1.807 0.062 -0.188 0.231 0.492 -0.903 0.439 -0.176 -0.637 #NUM! 0.883 0.243 -0.688
#NUM! #NUM! 0.463 0.266 0.321 0.400 0.387 -0.264 -0.638 #NUM! -0.650 #NUM! #NUM! -0.073 -0.409 0.358 #NUM! 0.245 0.367 -2.317 0.409 0.642 -0.187 0.781 -1.586 #NUM! 0.825 #NUM! 0.353 0.901 -0.336 -1.141 -0.116 0.687 -0.158 0.511 -0.149 -0.392 -0.026 0.069 0.105 0.475 -0.389 0.235 0.214 0.267 0.274 0.420 #NUM! 0.690 -0.286
0.352 0.172 0.704 -0.014 0.187 -0.166 1.347 -0.357 0.298 0.584 0.407 0.012 0.165 1.592 -0.429 0.785 0.352 -0.449 #NUM! -0.191 0.885 0.829 #NUM! #NUM! -0.126 3.051 0.054 -0.002 #NUM! 0.315 -0.454 0.986 0.875 -0.822 #NUM! 0.097 0.694 0.037 0.924 #NUM! #NUM! -0.468 #NUM! #NUM! 1.004 0.366 -0.361 -1.936 #NUM! 0.512 -0.298
2.477 0.691 -0.077 0.166 0.153 -0.045 -0.500 0.288 0.536 0.208 #NUM! 0.573 0.805 0.574 0.232 -0.162 0.535 0.606 0.094 0.387 0.790 0.348 0.537 #NUM! -0.414 #NUM! #NUM! -0.603 -3.130 -4.237 -0.474 0.293 1.054 -0.807 #NUM! #NUM! 0.916 -0.136 0.312 0.123 #NUM! 0.013 0.516 -0.043 #NUM! -1.667 -0.242 0.231 0.416 -0.240 -0.109
-0.354 0.091 #NUM! 0.660 -0.150 0.379 -0.162 0.450 -0.175 -1.164 #NUM! 0.130 0.084 #NUM! 0.122 0.833 -0.321 0.133 0.207 #NUM! -0.346 1.405 0.405 -0.545 0.124 -0.294 0.146 0.463 #NUM! 1.165 0.320 0.978 3.560 0.214 #NUM! -0.042 0.027 -1.171 #NUM! 0.205 0.204 -0.205 -0.155 0.123 -0.178 0.112 0.733 0.415 0.039 0.639 0.099
0.508 -0.549 -0.949 0.425 #NUM! 0.802 #NUM! 0.044 #NUM! 1.050 0.304 -1.899 -0.943 0.826 0.294 0.265 0.018 0.445 0.336 -0.254 -0.445 #NUM! 0.577 0.375 1.493 -0.313 #NUM! 0.515 #NUM! #NUM! 0.215 0.720 0.386 0.620 #NUM! 0.713 -1.413 -0.956 0.566 -0.817 #NUM! -0.334 -0.131 1.500 #NUM! 0.234 0.606 0.737 -0.719 0.284 0.449
-0.153 0.477 -0.171 #NUM! 0.078 0.226 -0.608 -0.164 #NUM! #NUM! -0.030 -0.860 -0.259 0.595 0.132 #NUM! -0.672 0.990 -0.190 -0.418 0.421 -1.032 0.266 0.212 0.292 0.329 1.063 0.718 0.149 0.147 0.083 0.618 -0.733 #NUM! #NUM! -0.406 -0.246 0.364 0.430 -0.018 0.044 #NUM! 0.348 2.457 #NUM! 0.379 0.322 #NUM! 0.331 -0.299 -0.856
0.536 0.777 0.535 0.840 0.144 0.344 -1.439 0.256 0.105 0.014 -0.094 -1.887 -0.139 0.121 0.525 0.360 0.978 0.240 #NUM! -0.048 0.067 -0.818 -0.046 0.137 -0.168 -0.659 0.365 -0.059 1.348 0.109 0.599 0.222 1.512 -0.554 0.038 #NUM! -0.120 0.217 #NUM! -0.118 -0.048 0.143 #NUM! 0.653 -1.826 1.534 #NUM! 0.239 -0.419 0.319 -3.785
0.015 0.479 0.373 0.722 #NUM! #NUM! #NUM! #NUM! #NUM! -0.090 0.440 2.019 -0.612 -0.926 0.161 #NUM! 0.639 #NUM! -0.549 -0.650 -0.279 -0.092 0.247 -0.526 -0.262 -0.374 -1.273 -0.401 -1.221 0.952 -0.175 -0.303 0.128 0.083 0.000 -0.012 #NUM! #NUM! 1.024 -0.169 -0.013 -0.026 0.254 #NUM! 0.274 -0.118 0.096 0.179 -0.127 0.857 -0.062
0.200 0.241 0.073 0.169 -0.025 0.237 -0.025 -0.415 0.088 -0.130 -0.365 0.015 -0.371 -0.145 0.599 1.252 0.518 0.066 0.811 -0.248 -0.376 1.437 0.354 0.864 0.657 0.142 2.853 0.021 0.548 0.212 0.255 0.267 #NUM! 0.367 #NUM! -0.212 #NUM! #NUM! #NUM! 0.405 #NUM! -0.310 -0.003 -0.368 -0.151 0.867 0.376 -0.639 0.303 -1.319 -0.850
-1.198 -2.906 -0.875 -1.289 #NUM! 0.070 #NUM! -0.112 0.065 #NUM! #NUM! #NUM! 0.355 0.361 -0.439 0.423 0.067 #NUM! 0.283 -0.408 -0.455 -0.306 0.026 -0.705 #NUM! -0.143 -0.527 0.505 -0.052 -0.239 0.249 0.006 2.311 -0.027 #NUM! #NUM! -0.311 -0.193 0.766 0.416 0.221 0.737 0.985 0.026 -0.680 0.451 0.718 0.311 0.144 -0.407 0.082
-0.066 -0.594 0.397 0.120 1.005 0.263 0.028 0.153 #NUM! 0.016 0.172 #NUM! -1.379 #NUM! 0.112 0.031 1.213 0.044 #NUM! #NUM! 0.080 -0.032 0.136 -0.653 -1.158 -0.964 0.571 -0.332 -0.340 0.172 -0.047 -0.285 0.596 -0.169 0.365 #NUM! 0.430 0.046 0.096 1.352 0.146 -0.220 -0.256 #NUM! -0.298 1.296 1.136 0.721 -0.111 -0.021 -0.779
0.086 1.078 0.305 0.145 0.407 0.413 0.582 0.411 0.399 0.029 0.474 0.209 0.674 -0.568 0.602 -0.814 1.650 0.385 0.427 0.421 -0.106 0.268 #NUM! 0.580 #NUM! #NUM! 0.753 #NUM! 0.372 0.231 0.255 -0.664 -0.407 0.806 0.111 0.559 1.090 #NUM! 0.477 0.111 0.165 #NUM! 0.559 1.317 0.261 0.341 -0.941 0.684 0.978 -0.193 -0.782
#NUM! 0.679 0.401 #NUM! 0.456 -0.190 1.952 -0.194 2.305 0.018 -0.558 -1.203 0.396 -0.172 0.010 -0.026 0.694 #NUM! -2.128 0.102 -0.237 -0.111 0.260 -0.438 1.742 0.417 0.673 0.392 0.408 -0.151 -0.196 0.365 -0.182 1.405 0.603 -0.010 -0.077 -0.117 0.373 -0.198 -0.147 -0.188 -0.165 0.658 0.068 0.435 1.195 0.134 -0.473 -0.084 -0.068
-0.078 0.431 #NUM! -0.243 0.339 -0.756 -0.098 -0.265 -0.110 0.164 -0.148 0.204 -0.260 0.693 -0.305 -0.221 0.166 -0.784 #NUM! 0.497 0.230 -0.021 0.258 0.496 0.866 -0.044 0.188 0.373 -0.034 -0.022 -0.728 0.091 -0.253 0.147 0.255 -0.114 0.337 -0.416 -1.879 0.546 -0.342 0.110 0.430 0.288 -0.409 0.846 1.302 -0.323 -0.395 1.399 0.488
#NUM! 0.387 0.285 0.107 0.536 0.173 0.292 0.572 0.574 -0.405 -0.321 -0.610 0.005 -0.183 0.188 0.108 0.324 1.024 0.421 0.254 0.725 0.087 0.558 0.270 0.836 -0.836 -0.768 0.183 0.142 -0.751 0.087 0.346 0.756 -0.470 -0.041 #NUM! 0.593 -0.075 #NUM! -0.277 -0.115 0.348 #NUM! 0.263 0.380 0.538 0.594 -0.073 -0.161 #NUM! 0.119
0.110 0.195 -0.094 0.097 0.203 #NUM! 0.123 0.293 0.716 -0.030 -0.865 0.807 -0.507 0.268 -0.027 0.359 0.073 -0.631 0.363 -0.220 -0.034 0.163 -0.703 -0.076 #NUM! 0.020 0.978 0.295 -0.145 -0.665 -0.145 -0.808 0.162 0.059 -0.043 0.923 -0.038 -0.274 -0.475 -1.035 #NUM! 0.140 0.623 0.131 0.448 -0.051 -0.652 0.551 -0.764 -1.252 #NUM!
#NUM! 0.263 -0.461 #NUM! -0.346 0.538 -0.703 #NUM! 0.598 0.607 1.158 #NUM! 0.635 0.175 -0.363 0.414 0.461 0.369 #NUM! 0.078 0.200 1.232 #NUM! 0.497 -0.256 0.148 -0.015 0.139 -0.639 -0.140 #NUM! 0.550 -0.406 -0.081 0.073 0.640 -0.447 0.455 0.812 0.391 #NUM! -1.093 0.176 0.109 0.670 0.027 0.653 0.462 0.731 0.311 1.698
#NUM! #NUM! #NUM! 1.003 0.514 0.195 0.144 0.492 -0.280 #NUM! #NUM! 0.537 0.082 -0.100 #NUM! 0.170 0.542 0.587 -0.032 0.224 0.319 0.155 0.355 0.246 0.363 #NUM! -0.322 -0.151 0.506 0.865 0.383 0.450 -1.293 0.055 0.237 -0.265 0.467 0.151 0.410 0.024 0.336 0.469 0.715 0.163 0.393 -0.227 -0.621 -0.011 -0.541 0.275 0.916
-0.193 #NUM! #NUM! -0.036 #NUM! 0.304 0.170 0.227 0.227 0.340 -0.416 0.526 0.354 #NUM! 0.710 0.017 -0.656 0.426 -0.005 0.180 0.168 -0.125 0.333 0.405 -0.072 -0.010 0.420 -0.257 0.670 0.407 0.143 -0.193 1.143 0.398 0.489 #NUM! 0.261 0.408 -0.102 0.046 0.124 0.444 0.068 #NUM! 0.350 0.389 0.161 0.195 0.321 0.380 0.158
0.896 0.679 0.194 0.159 0.106 1.147 0.193 0.749 -0.037 -0.181 0.516 -0.721 0.198 -0.421 0.856 0.162 0.446 -0.641 #NUM! #NUM! 0.305 -0.118 -0.531 0.185 -0.771 1.068 0.604 0.295 0.341 #NUM! #NUM! 0.270 -0.668 -0.082 0.159 -0.367 -0.344 -0.356 -0.292 0.104 -0.290 -1.182 #NUM! 1.509 #NUM! #NUM! 0.637 #NUM! -0.008 0.008 -0.876
#NUM! 0.977 #NUM! #NUM! 0.340 #NUM! -0.007 #NUM! -0.296 #NUM! 0.625 #NUM! #NUM! -2.564 1.279 1.361 #NUM! #NUM! -2.226 -1.147 #NUM! #NUM! #NUM! 0.102 #NUM! #NUM! #NUM! 3.729 0.166 #NUM! -0.282 0.070 1.346 #NUM! #NUM! #NUM! #NUM! #NUM! 0.072 -0.425 0.213 0.846 0.666 -0.752 0.443 -0.296 -0.784 -0.064 0.261 #NUM! -0.967
#NUM! 0.449 #NUM! #NUM! #NUM! -1.710 #NUM! #NUM! #NUM! #NUM! #NUM! #NUM! 1.439 #NUM! -1.957 #NUM! #NUM! #NUM! #NUM! #NUM! #NUM! -0.360 #NUM! -0.403 #NUM! 0.116 0.369 2.444 0.438 0.383 0.374 #NUM! 1.418 0.890 0.540 0.234 0.088 -0.107 0.176 -0.603 0.524 0.334 -0.373 0.403 0.511 -0.688 -0.831 -0.419 0.003 1.769 1.006
1.001 -0.148 0.082 0.436 0.259 0.039 0.172 0.592 0.681 #NUM! 0.173 0.245 0.045 2.361 -0.168 -0.142 0.020 -0.032 -0.346 0.237 -0.876 0.017 0.135 0.366 0.173 #NUM! -0.694 -0.989 0.137 0.333 0.985 0.126 -0.659 -0.015 -0.345 0.184 1.900 0.241 0.682 #NUM! -1.074 -0.089 -0.197 0.345 0.598 0.620 0.004 -0.305 #NUM! #NUM! #NUM!
0.118 #NUM! 1.289 #NUM! #NUM! 0.066 0.692 #NUM! -0.392 0.828 -0.381 0.253 -1.284 0.244 0.255 #NUM! 0.453 0.538 0.591 0.100 0.466 -1.230 0.440 0.277 -0.880 0.279 0.578 0.108 #NUM! -0.244 -0.294 -1.381 0.469 #NUM! 1.545 0.187 0.417 0.228 #NUM! #NUM! 0.439 0.197 0.112 -1.427 -0.663 #NUM! -0.034 0.112 1.009 -0.458 1.158
-0.082 0.324 0.414 0.324 -0.028 0.141 0.404 1.161 -0.257 0.979 1.644 0.156 1.788 0.966 -1.603 -0.274 -0.223 0.179 -1.860 0.334 -0.070 0.398 -0.748 -0.849 1.317 0.365 -0.576 -1.013 -1.393 #NUM! -0.841 #NUM! -0.800 0.690 -0.169 0.261 -0.211 0.469 -0.252 0.376 0.023 #NUM! #NUM! -0.030 0.248 1.303 #NUM! 0.358 0.850 0.418 0.324
0.465 1.075 -0.273 #NUM! -0.906 -2.285 -0.115 0.683 #NUM! -0.139 -1.085 -1.455 0.544 0.097 -0.893 0.154 -1.101 -0.310 -0.169 0.032 0.366 0.301 -0.057 -0.676 0.488 -0.028 #NUM! 0.748 0.391 -0.950 0.166 0.343 1.095 -0.319 0.030 -0.790 -0.484 0.746 #NUM! 4.657 0.470 -0.964 #NUM! -0.623 0.842 0.401 -0.133 0.181 0.128 -0.183 -0.031
0.238 -0.234 -0.411 0.097 #NUM! 0.289 0.354 #NUM! -0.318 -1.323 -1.325 -1.261 -0.022 -0.341 -2.313 -0.225 0.429 #NUM! -0.078 -0.075 #NUM! 1.746 -0.980 1.168 -1.949 0.078 0.168 #NUM! -0.129 #NUM! 2.306 #NUM! 0.306 0.655 0.115 0.134 -0.161 0.305 -0.594 -0.074 -0.609 1.159 0.819 0.224 0.296 -0.036 0.245 0.126 -0.296 -0.019 -0.709
-0.037 0.014 0.094 0.386 #NUM! 0.658 -0.185 0.848 -0.164 -0.533 #NUM! 0.869 -0.044 0.376 #NUM! -0.447 0.208 0.326 0.693 0.143 -0.022 0.161 -0.586 0.342 0.728 -0.463 -0.021 0.861 0.500 0.215 -0.919 -0.105 0.195 0.636 0.349 0.227 0.092 -0.017 -0.065 -0.449 -0.354 #NUM! -0.812 #NUM! 0.972 0.057 3.062 #NUM! 0.487 0.278 -0.539
-0.129 #NUM! 0.242 0.153 0.028 0.524 -0.007 -0.015 0.020 -0.551 #NUM! -0.731 0.267 0.539 0.079 0.815 0.572 #NUM! 0.676 0.386 -0.227 #NUM! #NUM! -0.301 #NUM! 0.275 0.362 -0.034 0.920 -0.028 0.394 0.103 0.383 #NUM! 0.324 0.536 -2.037 -0.822 3.405 0.340 0.391 0.367 0.026 1.190 0.264 0.347 1.260 #NUM! 0.048 0.285 0.372
0.299 0.882 1.059 0.658 -0.450 1.770 0.994 1.300 0.163 0.403 0.594 1.036 0.561 -1.056 0.476 -1.595 0.344 0.261 #NUM! -0.295 #NUM! -0.308 -0.237 0.162 0.460 -0.624 0.038 -0.360 0.689 1.109 -0.470 0.206 -0.187 0.273 1.908 2.855 -0.196 0.206 0.249 -0.666 1.615 0.066 -0.343 -0.352 0.320 0.749 0.204 0.235 -0.480 0.140 -0.196
0.004 0.429 0.290 2.808 #NUM! 0.580 -0.142 -0.536 -0.020 0.031 #NUM! -0.133 0.392 0.578 0.787 -0.431 #NUM! -0.583 0.435 0.415 0.388 0.699 -0.234 -0.186 -0.249 0.353 -0.115 0.143 0.525 #NUM! 0.091 -0.820 -0.058 0.358 0.589 -0.210 #NUM! #NUM! #NUM! 0.198 0.193 0.727 0.522 1.072 #NUM! 0.230 1.347 0.252 #NUM! -0.053 -0.110
#NUM! 0.383 0.887 0.482 0.176 0.037 0.073 -0.985 -0.724 0.591 0.168 -0.324 -0.338 #NUM! #NUM! -0.145 -0.010 0.166 0.197 0.134 0.947 0.839 -0.381 -0.117 0.420 -0.144 0.691 -0.376 0.363 -0.513 -0.105 -0.774 0.363 0.221 #NUM! -0.003 #NUM! 0.067 -0.095 0.567 0.145 0.090 -0.270 0.268 -3.231 -0.316 #NUM! -0.637 0.383 -0.689 0.039
0.501 0.434 -0.759 #NUM! 0.569 0.406 -1.533 #NUM! 0.952 0.349 #NUM! 1.314 0.146 #NUM! -0.267 0.396 0.891 0.264 0.021 -0.639 -0.204 0.523 -0.267 0.152 -0.565 -0.309 0.727 -0.001 0.430 0.888 #NUM! 0.789 -0.355 -0.382 0.797 0.374 0.274 0.127 0.451 0.248 -0.142 -0.047 0.365 #NUM! #NUM! -0.390 -0.317 0.540 0.272 -0.019 0.316
0.118 0.114 0.810 0.292 0.679 -0.199 -0.089 -0.343 0.094 1.699 -0.749 -0.286 0.154 0.463 -0.451 0.099 0.978 0.332 #NUM! -0.258 -0.094 -0.578 -0.165 -0.271 -0.251 -0.288 -0.052 0.261 0.548 0.693 0.212 -0.066 0.379 #NUM! 0.560 0.075 0.278 0.585 -0.047 -0.045 0.296 #NUM! 1.098 -0.057 -0.152 #NUM! 0.885 -0.204 0.229 0.566 0.361
0.034 0.278 0.270 1.348 0.219 -1.854 -1.199 -0.028 0.286 -0.038 0.875 -0.427 1.048 -0.554 0.683 0.816 #NUM! -1.096 #NUM! 0.662 0.944 0.457 0.685 #NUM! 0.432 1.338 0.287 0.310 1.555 0.057 -0.406 0.666 -0.113 -0.425 1.029 0.899 0.217 2.034 -3.261 0.081 -0.204 #NUM! -0.511 -0.877 #NUM! -0.243 0.722 -0.663 0.005 0.281 0.023
-0.967 -0.358 0.322 0.412 0.100 -1.236 0.290 0.461 0.690 -0.482 0.398 0.018 0.048 0.285 -0.370 0.180 0.573 -0.534 -1.007 -0.990 0.298 -0.389 -0.455 0.047 0.456 0.658 0.321 0.640 #NUM! -0.304 0.821 0.305 #NUM! 0.153 -0.216 2.003 0.062 -0.114 0.344 -0.100 0.491 0.561 0.477 0.343 0.220 0.325 #NUM! 0.042 0.141 0.200 0.602
-0.782 #NUM! 0.060 0.090 -0.196 -0.974 0.025 #NUM! 0.584 #NUM! -0.569 0.491 -0.023 0.405 0.426 0.235 -0.198 0.679 -0.837 0.548 -1.327 -0.521 0.048 0.493 0.331 0.226 -0.133 0.216 #NUM! 0.927 0.318 0.171 -0.049 0.373 0.110 0.227 #NUM! 0.332 0.855 #NUM! 0.367 -0.510 #NUM! 0.697 #NUM! 0.238 0.379 0.295 0.592 0.220 -0.309
0.402 0.415 #NUM! 0.462 0.344 #NUM! -0.429 0.065 0.072 0.018 0.366 1.270 0.253 0.599 -0.065 0.164 0.627 0.588 -0.795 0.649 0.784 -0.055 -0.267 0.427 0.268 0.517 0.106 -1.865 -0.199 #NUM! -0.028 0.120 -1.790 0.148 -1.192 -2.486 -0.142 0.409 0.076 0.065 -1.595 -0.148 0.294 0.147 0.665 0.572 0.712 -0.202 -0.231 -0.045 0.014
-0.170 0.339 0.170 -0.160 -0.089 0.287 0.643 1.022 -0.027 0.687 0.003 -1.250 -0.767 0.647 #NUM! 0.048 0.068 0.262 #NUM! 2.748 -0.013 0.374 -0.412 #NUM! #NUM! 0.891 2.558 -0.046 0.354 -0.863 0.547 0.566 0.150 0.983 0.143 0.200 -0.513 -1.798 0.094 -0.389 #NUM! -1.411 0.130 -0.201 -0.392 0.127 0.256 0.417 1.217 -0.199 -0.467
0.014 0.428 -0.745 #NUM! -0.277 0.615 0.189 #NUM! 0.167 -0.262 -0.088 0.397 0.613 0.253 0.510 0.222 0.343 0.436 0.241 1.033 0.084 0.500 1.413 0.210 #NUM! 0.222 0.460 2.354 0.675 -0.793 0.087 -0.104 -0.453 -0.162 0.455 -0.338 #NUM! -0.902 2.768 0.246 0.338 0.487 0.235 -0.503 -0.365 -0.230 -0.008 0.914 -0.598 -0.840 #NUM!
#NUM! -0.630 #NUM! -0.052 0.347 1.630 -0.135 0.219 -0.383 0.216 0.237 -0.655 #NUM! 0.360 1.952 -0.058 -0.111 -0.160 -0.850 -0.393 #NUM! -1.793 -1.042 -0.968 0.490 0.045 0.336 0.049 #NUM! -0.498 -0.228 1.137 -0.148 -0.737 0.110 -0.139 -0.247 0.190 1.889 #NUM! 0.569 -0.472 0.219 -0.258 #NUM! -0.143 0.158 0.070 #NUM! 0.762 0.314
0.574 -0.303 0.479 0.222 -0.342 0.373 -0.010 #NUM! -0.027 -0.436 0.134 2.702 -0.353 -0.114 #NUM! 0.503 -0.411 0.033 0.478 0.381 0.483 -0.359 #NUM! -0.239 1.637 0.621 0.456 0.342 0.449 0.331 0.175 0.463 -1.045 0.892 0.087 0.481 1.431 0.327 -0.123 0.120 -0.419 0.496 0.685 0.398 0.076 0.690 0.530 0.718 0.072 #NUM! 0.008
-1.044 -0.932 -0.499 -0.344 0.369 #NUM! -0.169 -0.230 0.359 0.358 0.026 0.391 0.119 0.739 0.594 0.369 0.155 -0.282 -1.743 #NUM! -0.424 0.252 0.151 0.650 0.331 0.547 0.655 -0.062 1.140 -0.671 #NUM! 0.011 -0.470 0.976 0.015 -0.195 #NUM! #NUM! -0.119 #NUM! 0.464 -0.364 -0.912 -1.531 0.411 0.234 0.851 0.233 1.042 0.437 -0.745
3.349 0.904 -1.531 0.262 0.417 0.232 0.191 -0.048 1.303 0.434 -0.395 0.435 -0.538 -0.691 -0.572 0.098 0.117 1.833 0.062 #NUM! 0.254 0.157 -2.693 -0.247 -0.190 0.340 -0.018 0.042 -0.198 0.085 0.548 #NUM! 0.334 0.418 -0.374 0.458 0.977 0.419 0.202 -0.705 -0.961 0.075 -0.122 -0.216 0.328 -0.189 -1.658 #NUM! -0.592 -0.298 -0.206
-0.095 0.210 #NUM! 0.703 0.056 0.228 0.042 0.278 -0.326 0.547 -0.772 0.113 -0.228 #NUM! -0.772 -0.216 -0.589 -0.106 0.005 0.274 0.329 #NUM! -0.268 -0.071 0.692 0.219 0.390 1.648 #NUM! 0.309 0.513 0.358 #NUM! #NUM! 0.454 0.303 -0.028 -0.249 0.343 1.212 0.738 0.221 -0.061 -0.067 -0.079 -0.055 -0.294 0.420 0.067 0.450 -0.366
-0.442 0.109 -0.203 -0.191 0.200 0.479 -0.025 0.362 0.344 -1.849 -0.194 #NUM! 0.721 0.212 -0.324 0.207 0.531 0.318 0.680 -1.461 0.144 0.387 0.033 0.296 0.007 0.770 0.377 0.332 0.626 0.292 0.016 0.761 0.386 0.185 0.957 0.644 0.358 0.666 0.029 -0.535 #NUM! -0.530 1.177 -0.996 #NUM! 0.330 0.011 0.820 0.197 0.274 0.095
0.348 -0.623 0.219 0.133 0.192 0.274 0.570 0.369 1.002 0.081 0.602 -1.177 0.181 1.427 0.426 #NUM! -0.023 0.205 0.154 -0.019 1.017 0.495 -0.958 0.564 -0.566 #NUM! 1.470 -1.967 #NUM! 0.251 0.414 -0.076 -0.559 0.438 2.247 -0.031 0.272 #NUM! -0.302 #NUM! 0.844 0.123 #NUM! 0.547 0.241 0.092 0.385 0.592 -0.048 0.320 0.881
-0.270 0.302 -0.016 -0.009 -0.667 #NUM! -0.484 -0.317 0.085 0.093 0.689 -0.315 -2.407 1.155 0.285 0.372 #NUM! 0.344 0.392 -0.525 0.560 0.754 -0.642 -0.238 #NUM! -0.409 -0.202 0.021 #NUM! -0.298 0.645 -0.188 #NUM! 0.209 -1.256 0.913 0.419 0.213 -0.572 #NUM! 0.516 -0.494 -0.565 #NUM! 0.536 -1.389 0.237 -0.199 #NUM! -0.957 -0.260
0.313 0.116 0.358 #NUM! 0.295 #NUM! -0.727 #NUM! #NUM! #NUM! -0.524 -1.774 #NUM! 1.757 -0.027 0.018 0.027 -0.134 -0.190 0.123 0.480 0.281 0.367 #NUM! 0.552 -0.572 0.041 -0.034 2.740 -0.074 0.002 0.478 0.417 0.777 1.100 -0.496 -0.370 -0.293 -0.572 0.252 0.057 0.167 1.409 0.969 0.144 1.477 0.053 1.108 0.015 #NUM! -0.111
0.742 #NUM! 0.501 0.664 #NUM! -0.040 -0.089 -0.923 #NUM! -0.627 -0.326 1.012 #NUM! -0.460 -0.093 -0.219 0.123 -0.449 0.958 0.104 0.550 -0.184 -0.234 -0.067 -0.247 -0.494 0.248 #NUM! 0.024 0.095 0.161 -0.157 #NUM! 0.465 #NUM! 0.262 #NUM! -0.185 -0.008 0.259 -0.258 -0.429 -0.548 0.029 0.100 -0.240 -0.213 -1.112 #NUM! #NUM! #NUM!
0.140 0.420 0.141 0.145 #NUM! -0.090 -0.057 -0.164 #NUM! #NUM! 0.053 0.382 0.491 0.762 -0.360 -0.517 -0.447 0.025 0.194 0.835 0.119 0.294 0.570 0.569 0.205 -1.450 0.558 0.437 0.363 -0.133 0.653 0.107 0.154 0.686 #NUM! 0.001 0.375 -0.016 1.501 #NUM! -1.549 -1.481 -0.017 0.634 0.085 0.332 0.317 -0.080 0.272 0.369 0.478
0.578 0.664 -0.330 0.696 -0.102 0.298 -0.295 2.365 0.963 0.286 0.347 #NUM! 0.077 #NUM! 0.001 0.332 -0.483 -0.532 0.396 0.831 -0.269 0.147 0.252 -0.126 0.457 0.370 1.292 0.422 1.098 0.443 -0.002 0.004 0.040 0.262 0.129 #NUM! -0.312 0.081 0.601 0.259 #NUM! -0.539 0.669 1.599 -0.270 #NUM! 0.112 #NUM! -0.984 -0.135 -1.728
1.379 -0.155 0.432 -0.224 0.047 -0.267 -0.290 0.476 -0.033 0.689 0.213 1.144 0.128 -0.124 -0.435 #NUM! -0.043 0.413 0.807 0.570 0.317 0.213 0.312 0.124 #NUM! 0.074 0.588 0.084 0.041 -0.304 0.540 #NUM! #NUM! 0.082 -0.364 0.940 0.611 0.554 0.385 0.291 #NUM! -0.184 -0.039 -0.401 #NUM! -0.481 0.352 0.253 -0.185 -0.115 0.282
0.375 0.165 0.270 0.308 0.651 0.206 0.286 -0.174 -0.028 -0.051 0.423 0.092 1.518 2.242 0.166 0.434 0.059 0.095 0.090 -0.672 0.148 0.067 #NUM! -0.055 0.244 0.576 -0.432 1.188 1.451 0.400 0.711 0.883 0.583 -0.008 0.553 0.627 -0.019 0.132 -0.019 -0.534 0.585 0.803 -0.009 1.225 -0.989 #NUM! 0.558 -0.157 0.515 0.006 0.197
-0.374 0.632 -0.135 0.850 -0.236 0.933 0.065 1.202 -0.226 0.253 0.676 -0.283 0.507 #NUM! 0.494 -0.318 1.798 0.434 #NUM! 0.450 0.251 -0.383 0.765 -0.965 -0.133 0.690 0.617 0.255 0.071 0.292 0.347 -0.613 0.180 -0.238 0.176 -1.291 2.027 -0.344 -1.732 0.295 0.893 0.320 #NUM! 0.569 #NUM! -0.006 #NUM! 0.417 0.347 #NUM! 0.721
0.581 #NUM! #NUM! 0.296 0.405 -0.669 #NUM! -0.422 -0.534 -0.418 -0.172 -0.768 0.316 -3.735 -0.141 0.261 0.871 -1.247 1.394 0.188 -0.178 -0.893 #NUM! 0.477 -0.069 0.389 0.036 -0.136 0.348 0.283 0.334 0.263 0.043 0.158 0.013 1.087 0.354 -0.768 -1.161 0.078 -0.260 0.143 0.568 0.083 0.758 0.100 0.892 0.897 0.920 1.261 -0.072
-0.501 1.262 #NUM! #NUM! 0.086 -0.831 -0.046 -0.672 #NUM! 0.271 0.207 0.297 0.493 -0.042 0.500 -1.365 0.406 -0.471 1.317 -0.272 -1.101 0.327 0.082 1.674 0.182 0.588 -0.384 0.338 -1.396 #NUM! -0.016 0.307 -0.075 #NUM! 0.400 -0.142 #NUM! -1.445 #NUM! 0.369 1.656 1.130 0.346 -0.813 -0.038 -0.143 0.079 0.722 -0.265 -0.177 -0.022
0.393 #NUM! -0.542 -1.097 -0.418 #NUM! 0.060 #NUM! 0.242 -1.761 0.410 -0.080 0.088 0.339 0.278 0.133 -0.422 -0.257 0.105 0.038 0.255 0.125 -0.160 -0.410 0.490 0.323 0.422 0.141 -0.329 -0.562 0.655 -0.306 0.335 0.785 -0.904 0.403 0.028 -0.769 0.213 1.004 0.035 0.373 -0.311 -0.165 0.160 -0.034 1.313 -0.215 -0.216 -0.296 -0.363
-0.406 0.298 -0.129 0.387 #NUM! 2.497 -0.260 0.319 0.560 0.358 0.179 -0.219 0.643 #NUM! -0.190 0.272 0.190 #NUM! 0.025 -0.204 0.176 0.366 0.292 0.323 1.710 -0.223 -0.353 -0.441 1.307 0.291 -0.623 #NUM! -0.852 0.913 0.252 -0.966 0.726 -1.693 -1.077 -0.323 -0.083 -0.801 #NUM! 0.122 -0.215 -0.140 -0.745 -0.959 -0.319 0.278 0.294
-0.503 -0.145 0.195 1.688 1.340 #NUM! -1.459 0.546 2.301 -0.471 #NUM! #NUM! #NUM! 0.137 #NUM! -0.305 0.036 0.551 0.870 0.320 -0.554 0.065 0.974 -0.283 #NUM! -0.365 0.814 -0.117 #NUM! #NUM! 0.650 #NUM! #NUM! 0.183 0.380 1.584 -0.055 #NUM! #NUM! -0.275 0.667 0.279 #NUM! 1.378 #NUM! -0.660 0.264 0.349 0.329 0.040 -0.818
-0.233 -0.235 0.084 #NUM! 0.308 0.516 0.006 0.226 -0.382 -0.318 0.052 -0.060 0.274 0.498 -0.520 0.091 0.808 0.477 0.471 0.622 -0.483 0.027 -0.184 0.413 0.289 -0.983 0.118 0.471 -0.406 #NUM! 0.054 0.394 0.340 0.097 -0.251 -0.010 0.300 0.297 -0.239 0.001 0.351 -0.016 -0.107 0.250 0.329 -0.383 0.399 -0.524 0.997 0.524 0.127 -0.104
-0.391 -1.863 -1.735 -0.779 0.497 -0.383 -0.573 #NUM! -0.180 0.640 0.613 #NUM! 0.316 0.238 #NUM! 0.214 0.302 0.453 -0.154 -0.357 -0.491 0.212 0.141 #NUM! 0.197 -0.167 -0.565 0.311 0.478 -0.981 1.048 0.461 -0.042 -0.105 0.146 0.674 0.195 0.045 -0.250 0.012 -0.092 0.352 0.892 0.084 -0.582 0.127 #NUM! #NUM! 0.155 0.206 -0.810
-0.604 -0.238 0.357 0.372 -0.084 -0.814 -0.659 1.039 0.034 0.581 0.491 0.339 0.117 -0.274 0.043 0.570 -0.055 0.196 -0.918 -0.209 #NUM! -0.052 0.156 0.150 -0.095 0.016 0.199 -0.234 0.481 0.167 -0.283 #NUM! -0.755 -0.186 #NUM! 2.247 -0.554 0.025 0.360 -0.478 0.008 -0.874 -0.649 1.060 #NUM! -0.122 0.003 0.289 0.474 0.185 0.530
-0.168 0.678 #NUM! -0.378 -0.021 0.358 1.653 -1.500 0.207 -0.374 -0.375 0.194 0.671 0.173 -0.125 0.182 0.086 0.718 0.137 1.821 0.466 0.676 0.196 #NUM! #NUM! -0.056 -0.020 -0.141 0.709 0.294 -0.091 0.107 -0.829 1.074 0.243 0.585 -2.421 0.447 0.267 1.294 -0.253 -0.202 0.357 0.276 0.106 0.161 #NUM! 1.137 0.004 0.122 0.302
0.466 0.452 -0.344 0.273 -0.371 0.539 #NUM! 0.541 0.077 0.290 0.573 0.979 0.182 0.349 0.085 0.812 0.499 -1.412 0.083 0.410 -0.034 -0.746 0.446 0.108 #NUM! 0.020 0.067 -0.312 -0.607 -0.222 -0.035 -0.345 0.174 0.077 0.285 -0.189 -0.081 0.413 0.071 0.067 -0.300 0.087 -0.180 0.146 -0.302 -0.919 -0.161 0.666 1.132 1.376 -0.283
-1.091 #NUM! -0.661 0.234 -0.741 0.377 0.388 0.736 0.352 0.142 0.314 -0.218 -0.188 0.564 0.477 -0.583 #NUM! 0.905 0.190 0.147 -0.176 0.487 -1.089 -0.454 -0.585 #NUM! 0.397 -0.002 -0.405 0.277 -0.624 -0.217 0.513 -0.125 -0.145 0.320 0.479 -0.281 -0.479 -1.019 0.540 0.280 -0.969 -0.630 0.416 -0.356 0.407 -0.248 0.625 0.695 0.655
0.202 -0.014 0.446 0.121 0.310 0.156 0.274 0.350 0.397 0.143 0.332 0.576 0.773 0.419 0.651 0.750 0.156 0.608 0.688 0.308 0.632 0.611 0.865 0.497 0.128 0.466 0.231 0.700 0.360 0.279 #NUM! 0.749 0.076 0.738 0.354 0.098 -0.162 0.076 -0.327 0.390 0.180 0.318 -0.773 #NUM! -0.214 -0.228 0.263 0.669 -0.366 -0.022 0.081
0.256 -0.143 -0.029 -0.346 0.437 0.268 0.117 0.265 0.257 0.178 1.437 0.332 1.437 -0.528 -0.015 -0.134 -0.215 0.373 -1.392 -0.482 0.512 #NUM! 0.049 1.374 0.198 -0.240 0.120 0.027 -0.059 -0.244 0.078 0.430 -3.239 0.875 1.233 -0.566 0.175 -0.216 0.392 -0.117 0.604 0.119 -0.070 0.394 -0.206 1.246 0.384 0.490 0.379 0.638 0.292
-0.047 -0.366 0.265 0.327 -0.231 #NUM! 0.338 0.457 0.342 0.501 0.398 0.437 0.265 0.527 0.407 0.054 0.376 0.567 0.401 0.126 0.499 -0.479 0.067 -1.831 0.498 #NUM! -0.866 0.354 0.081 -0.059 0.087 0.656 0.080 0.079 -0.419 0.566 0.339 -0.359 0.575 0.025 #NUM! -0.032 -0.040 0.270 0.337 0.256 0.488 0.085 0.488 -0.049 0.354 0.273
0.268 0.059 0.401 0.465 0.337 0.041 0.296 0.135 0.359 -0.745 0.270 -0.031 0.321 0.499 -0.109 0.276 0.310 0.276 0.192 0.495 -0.649 0.461 1.000 0.083 0.269 1.340 0.655 -0.229 0.533 0.234 0.072 0.313 0.242 0.233 0.431 0.069 0.029 0.453 0.040 0.433 0.315 0.159 0.289 0.601 0.338 0.129 0.559 2.971 0.202 -0.449 0.411 0.525
0.180 0.219 0.439 0.265 0.249 0.260 0.058 0.421 0.322 0.321 0.150 0.411 0.597 -0.566 0.463 -0.111 0.215 0.455 0.527 -0.031 1.721 0.262 -0.017 0.418 0.173 -0.031 0.027 #NUM! 0.144 0.009 0.394 0.300 #NUM! 0.309 0.203 0.088 0.404 0.144 0.559 0.073 0.437 -1.626 0.157 0.389 0.177 1.044 0.135 0.176 0.407 -0.279 0.830 0.500
0.571 0.020 0.373 0.263 #NUM! 0.307 0.405 0.150 0.409 0.405 0.536 0.322 0.786 0.349 0.540 0.399 0.708 -0.269 2.694 0.787 0.360 0.187 0.802 0.076 0.519 0.372 0.279 0.308 0.086 0.210 0.244 0.381 0.174 0.247 0.361 0.121 0.257 0.108 0.119 0.394 0.720 1.242 2.888 0.425 0.468 0.195 0.941 0.212 0.865 1.133 0.350 0.330
0.157 0.654 0.217 0.201 0.254 0.451 0.189 0.455 0.460 0.000 0.347 -0.026 0.237 0.319 0.378 0.055 -0.480 0.380 0.200 -0.282 0.321 -0.301 0.244 -0.079 0.443 #NUM! 0.592 0.316 -0.223 0.194 -0.272 0.721 0.133 0.396 0.379 0.130 0.633 0.363 0.643 0.689 0.562 0.055 #NUM! -0.005 0.577 0.282 0.588 0.180 0.242 1.922 0.247 0.890
0.606 0.370 0.784 0.080 0.797 #NUM! 0.479 0.338 0.413 0.214 0.133 0.482 -0.338 -0.222 0.417 0.280 0.277 -0.050 -0.124 0.459 0.029 0.111 #NUM! -0.152 0.598 -0.172 -0.474 0.502 0.298 0.067 0.453 -0.329 0.451 -0.483 -0.489 0.167 0.321 0.158 0.253 0.139 0.257 -0.232 0.454 0.558 0.719 0.115 -0.376 0.145 -0.505 -0.880 0.429 0.176
-0.219 0.228 0.475 0.168 0.176
