8 Weeks of Resistance Training Effect on Myostatin Gene Expression ...

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Mar 5, 2016 - [21] Strength training with blood How restriction diminishes myostatin gene ... [22]. Impact of resistance loading on myostatin expression and ...
©2016 ASP Ins., Afarand Scholarly Publishing Institute, Iran ISSN: 2252-0805 Quarterly of the Horizon of Medical Sciences 2016;22(2):111-116

8 Weeks of Resistance Training Effect on Myostatin Gene Expression of Myocardium in Healthy Male Wistar Rats ARTICLE INFO Article Type Original Research

Authors Rashidlamir A.* PhD, Basami M.R.1 PhD, Attarzadeh Hosseini S.R.2 PhD, Hejazi K.2 PhD, Motevalli Anberani S.M.2 MSc

How to cite this article Rashidlamir A, Basami M.R, Attarzadeh Hosseini S.R, Hejazi K, Motevalli Anberani S.M. 8 Weeks of Resistance Training Effect on Myostatin Gene Expression of Myocardium in Healthy Male Wistar Rats. Quarterly of the Horizon of Medical Sciences. 2016;22(2):111-116.

ABSTRACT

Aims Based on the clinical studies, there are higher myostatin gene expression and serum level in cardiovascular patients than the healthy persons. In addition, based on some studies, regular resistance exercises is in line with a reduction in the myostatin gene expression. The aim of this study was to investigate the effects of 8-week resistance exercises on the myostatin gene expressions of myocardium in the healthy male Wistar rats. Materials & Methods In the experimental study, 13 male adult Wistar rats, aged 15 weeks, were divided into experimental (n=7) and control (n=6) groups. In experimental group, 8-week exercises were done as climbing up a 26-step 1-meter ladder, inclined 85°, with a sinker. (There were 3 sessions a week exercises; each session consisted of 3 sets of 5 repetitions.) 24 hours after the last exercise session and after 12-hour fasting, the rats being dissected, muscle tissue samples were prepared to assess mRNA levels. Data was analyzed in SPSS 16 software using independent T test. Findings After 8-week resistance exercises, there was no significant difference in the myostatin mRNA expression level in the myocardium between experimental (1.56±0.44) and control (1.94±0.55) groups (p=0.197). Conclusion 8-week resistance exercises leads to no significant change in the myostatin gene expression of myocardium in the healthy Wistar male rats. Keywords Myostatin; Gene Expression; Resistance Training; Myocardium

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*Sport Physiology Department, Sport Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran 1 Clinical Sciences Department, Veterinary Medicine School, Ferdowsi University of Mashhad, Mashhad, Iran 2 Sport Physiology Department, Sport Sciences Faculty, Ferdowsi University of Mashhad, Mashhad, Iran Correspondence Address: Faculty of Physical Education and Sport Sciences, Paradise Daneshgah, Azadi Square, Ferdowsi University of Mashhad, Mashhad, Iran. Post code: 91779-48979 Phone: +98518833910 Fax: +98518829580 [email protected] Article History Received: May 6, 2015 Accepted: January 2, 2016 ePublished: March 5, 2016

[1] The role of aerobic exercise on endothelial function and on ... [2] Temporal onset, risk factors, and outcomes ... [3] Association of usf1s2 variant in the upstream stimulatory factor 1 gene with ... [4] The effect of a six- month aerobic exercise on levels of GH, IGF-1 and GH/IGF-1 ratio serum in sedentary ... [5] Myostatin, a transforming growth factor-beta superfamily member, is expressed in ... [6] Genetic deletion of myostatin from the heart prevents skeletal ... [7] Regulation of muscle mass by follistatin and ... [8] Quantitative trait loci affecting growth and carcass composition of ... [9] Myostatin: A modulator of skeletal-muscle stem ... [10] Mutations in myostatin (GDF8) in double-muscled Belgian Blue ... [11] Regulation of skeletal muscle mass in mice by a new ... [12] Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in ... [13] Genome-wide atlas of gene expression in the adult mouse ... [14] The effect of resistance training on serum myostatin level and insulin ... [15] Myostatin gene expression is reduced in humans with heavy-resistance ... [16] Effects of heavy resistance training on myostatin mRNA and protein ... [17] Effect of swimming on myostatin expression in white and red gastrocnemius muscle and in ... [18] Resistance training induces muscle-specific changes in muscle mass and ... [19] Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in ... [20] MSTN mRNA after varying exercise modalities in ... [21] Strength training with blood How restriction diminishes myostatin gene ... [22] Impact of resistance loading on myostatin expression and cell cycle regulation in ... [23] Myostatin knockout mice increase oxidative muscle phenotype as an adaptive response to ... [24] Grip force, EDL contractile properties, and ... [25] Time course of proteolytic, cytokine, and ... [26] MSTN mRNA after varying exercise modalities in ... [27] Myostatin inhibition enhances the effects of exercise on performance and ... [28] Alterations in myostatin expression are associated with changes in ... [29] Myostatin does not regulate cardiac hypertrophy or ... [30] Myostatin negatively regulates satellite cell activation and ... [31] Myostatin, a negative regulator of ... [32] Myostatin is an inhibitor of myogenic ...

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