a) b) c - PLOS

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Comment
A verage Number of. Parameters After Refinement igf1 ras pi3k il1a traf6 il6 stat3 lps tgfa tnfa mkk4 map3k7 jnk12 mek12 map3k1 akt p70s6 p90rsk msk12 irs1s.
Average MSE After Refinement

0.18

70 65

0.16

60

0.14

55

0.12

50

0.1

45 40

0.08

35

0.06

30

0.04

25

0.02 -4 10

b)

tnfa

-3

-2

10 10 10 Selection Threshold

il1a

lps

map3k7

map3k1

mkk4 jnk12

20 0 10

-1

tgfa

igf1

ras

pi3k

traf6 akt

il6

mek12

ikk p38 msk12 p53

c) NO-CYTO

TNFa

ikb

gsk3

p90rsk

histh3

creb

Ligand Stimulation IL1a

IL6

NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

hsp27

NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

cjun

Average Number of Parameters After Refinement

a)

IGF1

mtor irs1s

TGFa

p70s6

LPS

AKT

Ikb JNK12 p38 p70S6 p90RSK STAT3 cJUN CREB HistH3 HSP27 IRS1s MEK12

Inhibitor Measured value not reliable

0

0.25

0.5

0.75

Absolute Error

1

NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

p53 NO-INHIB MEK12i p38i PI3Ki IKKi mTORi GSK3i JNK12i

Species’ phosphorylation

GSK3

stat3