Eur Radiol (2012) 22:2790–2797 DOI 10.1007/s00330-012-2527-x
HEPATOBILIARY-PANCREAS
A comparison of MR elastography and 31P MR spectroscopy with histological staging of liver fibrosis Edmund M. Godfrey & Andrew J. Patterson & Andrew N. Priest & Susan E. Davies & Ilse Joubert & Anant S. Krishnan & Nyree Griffin & Ashley S. Shaw & Graeme J. Alexander & Michael E. Allison & William J. H. Griffiths & Alexander E. S. Gimson & David J. Lomas
Received: 17 January 2012 / Revised: 22 March 2012 / Accepted: 1 April 2012 / Published online: 1 July 2012 # European Society of Radiology 2012
Abstract Objectives Conventional imaging techniques are insensitive to liver fibrosis. This study assesses the diagnostic accuracy of MR elastography (MRE) stiffness values and the ratio of phosphomonoesters (PME)/phosphodiesters (PDE) measured using 31P spectroscopy against histological fibrosis staging. Methods The local research ethics committee approved this prospective, blinded study. A total of 77 consecutive patients (55 male, aged 49±11.5 years) with a clinical suspicion of
E. M. Godfrey St James’ Hospital, Beckett Street, Leeds LS9 7TF, UK A. J. Patterson : A. N. Priest : S. E. Davies : I. Joubert : A. S. Krishnan : A. S. Shaw : G. J. Alexander : M. E. Allison : W. J. H. Griffiths : A. E. S. Gimson Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK N. Griffin St Thomas’s Hospital, Westminster Bridge Road, London SE1 7EH, UK D. J. Lomas Department of Radiology, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0QQ, UK E. M. Godfrey (*) Department of Radiology, St James’ Hospital, Beckett Street, Leeds LS9 7TF, UK e-mail:
[email protected]
liver fibrosis underwent an MR examination with a liver biopsy later the same day. Patients underwent MRE and 31P spectroscopy on a 1.5 T whole body system. The liver biopsies were staged using an Ishak score for chronic hepatitis or a modified NAS fibrosis score for fatty liver disease. Results MRE increased with and was positively associated with fibrosis stage (Spearman’s rank00.622, P
