a design of experiment approach for optimization and ...

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ETODOLAC TERNARY SYSTEM USING SPRAY DRYING. Original ... was to prepare and characterize Etodolac (ETO), Polyvinyl pyrrolidone K30 (PVP K30) and.

International Journal of Pharmacy and Pharmaceutical Sciences Shaikh et al. ISSN- 0975-1491

Int J Pharm Pharm Sci, Vol 9, Issue 2, 233-240 Vol 9, Issue 2, 2017

Original Article

A DESIGN OF EXPERIMENT APPROACH FOR OPTIMIZATION AND CHARACTERIZATION OF ETODOLAC TERNARY SYSTEM USING SPRAY DRYING AMIR A. SHAIKH*1,2, PRAVEEN D. CHAUDHARI3, SAGAR S. HOLKAR2 1CRD,

PRIST University, Vallam, Thanjavur, T. N., India, 2Dept. of Pharmaceutics, SCES’s Indira College of Pharmacy, Pune, M. S. India, 3PES’s Modern College of Pharmacy, Pune, M. S., India Email: [email protected] Received: 08 Nov 2016 Revised and Accepted: 21 Dec 2016

ABSTRACT Objective: The objective of the present investigation was to prepare and characterize Etodolac (ETO), Polyvinyl pyrrolidone K30 (PVP K30) and Hydroxypropyl β-cyclodextrin (HPB) ternary system in order to study the effect of complexation on solubility of ETO.

Methods: Physical mixtures of a drug and polymers in different weight ratios (1:1, 1:2, 1:4) were prepared to study the effect of individual polymers on solubility of ETO. Spray drying method was used to investigate the combined effect of PVP K30 and HPB on saturation solubility (SS), Dissolution efficiency (DE) and mean dissolution time (MDT) of ETO. Design of experiment (DoE) was used for preparation and optimization of ternary system. Drug polymer interactions were analyzed with Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Scanning electron microscopy (SEM), Xray diffraction (XRD) and particle size analysis. Results: Results of solubility study suggested that there was significant increase in solubility of ETO with increase in the concentration of PVP K30, Polyvinyl pyrrolidone K 90 (PVP K90) and HPB (*p