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After skin incision, anesthetic doses were increased until EEG burst suppression (BS) occurred. (figure 1). Subsequently, anesthesia was performed according to.
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A multimodal integration of standard and EEG parameters significantly exceeds the performance of the current standard of “depth of anesthesia” monitoring. Included EEG analysis methods of AMI reduce influence of surrogate muscle activity in EEG as well as index calculation time. These improvements should lead to a more reliable detection of awareness, thereby reducing the risk of memory recall.
The AMI showed PK of 0.93 (CI: 0.92-0.94) for separation of different levels of anesthesia (wakefulness to EEG burst suppression), whereas BIS has a significantly lower PK of 0.80 (0.78-0.81). At the transition between consciousness and unconsciousness (LOC and ROC) AMI yields PK of 0.85 (0.820.87), which is significantly higher than PK of 0.74 (0.71-0.77) for BIS (threshold p
