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Proceedings of the IEEE-EMBS International Conference on Biomedical and
Health Informatics
(BHI 2012). Hong Kong and Shenzhen,
China
, 2-7 Jan 2012.
Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012) Hong Kong and Shenzhen, China, 2-7 Jan 2012
A Novel Method to Estimate Baroreflex Sensitivity Based on Pulse
Transit Time Qing Liu, Carmen, C. Y. Poon, and Yuan-ting Zhang
domain and the sequence method in the time domain are two
Abstract- Baroreflex sensitivity (BRS) has emerged as a prognostic
factor
in
cardiology.
Spontaneous
main categories of spontaneous techniques for measuring
sequence
technique is one of the most commonly used methods in
BRS.
measuring BRS. The technique requires continuous beat-to-beat blood
pressure
(BP)
which,
however,
cannot
be
Continuous measurement of electrocardiogram (ECG) and
obtained
BP enables the spontaneous BRS estimation. Nevertheless,
conveniently. Considering that pulse transit time (PTT) is
state-of-art BP meters can only provide intermittent BP
inversely related to BP and can be easily and continuously acquired
from
electrocardiogram
(ECG)
reading or use an intlatable cuff which limits the size and
and
photoplethysmogram (PPG), we proposed in this study a novel
power
method that estimates BRS from PTT based on the sequence
measurement still remains a challenge, making acquisition of
technique
BRS difficult. Alternatively, pulse transit time (PTT) which is
with
low-pass
filtering.
The
experiment
was
conducted on 25 healthy subjects from whom continuous BP,
consumption
of
the
devices.
Continuous
BP
the time taken for a pressure pulse wave to travel along the
PTT and R-R interval (RRI) of ECG were obtained before,
artery and arrive at the periphery has shown high correlation
during and after drinking 400ml of water. SBP-based BRS and PTT-based BRS were separately calculated. The results showed
with BP and given promising results in continuous BP
high correlations between these two BRS estimates in all
measurement
situations (correlation coefficient y=0.90, 0.70 and 0.81 before,
beat-to-beat
during and after drinking respectively). Furthermore, results
photoplethysmogram (PPG) which both can be achieved by
from both methods indicate that BRS increased significantly
B
of
pressure
(BP)
[1].
Baroretlex
of
on
ECG
a
and
from BP and HR. In addition, based on previous literatures [5, would induce variations in BP.
risk of developing essential hypertension [2]. Alterations of in
acquired
6], water drinking is used in this study as a daily activity that
interval to the change of BP is of clinical relevance in
changes
be
a new method to estimate BRS from PTT and HR using the
predicting the risk of sudden cardiac death and evaluating the indicate
can
measurement
sequence method and compare the estimates to those obtained
sensitivity (BRS) which retlects the response of an inter-beat
BRS
PTT
technique. Therefore, the objective of this study is to propose
INTRODUCTION
blood
from
used as a surrogate of BP for BRS assessment using sequence
AROREFLEX is a basic mechanism for the short-term regulation
Since
wearable devices, it is proposed in this study that PTT can be
(p
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