Apr 5, 2017 - 1Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology,. Medicine & Health, University of Manchester, Manchester, UK ... 3Department of Paediatric Endocrinology, Royal Manchester ...
Research
R Perchard et al.
Vitamin D and HbA1c in T1D
225–231 6:4
225–231 6 : 225
Open Access
A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D) R Perchard1, L Magee1, A Whatmore1, F Ivison2, P Murray1,3, A Stevens1, M Z Mughal3, S Ehtisham3, J Campbell3, S Ainsworth3, M Marshall2, M Bone4, I Doughty4 and P E Clayton1,3 1
Endocrine Connections
Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK 2 Department of Biochemistry, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK 3 Department of Paediatric Endocrinology, Royal Manchester Children’s Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester, UK 4 Department of General Paediatrics, Royal Manchester Children’s Hospital, Central Manchester Foundation Hospitals NHS Trust, Manchester, UK
Correspondence should be addressed to P E Clayton Email peter.clayton@manchester. ac.uk
Abstract Background: Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c. Aims: (1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c. Methods: Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level 10 years) units. HbA1c levels before and after treatment were recorded. Results: Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH) D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = −0.484, P
