Accepted Manuscript Divided Consumption of Late-Night-Dinner Improves Glycemic Excursions in Patients with Type 2 Diabetes: A Randomized Cross-over Clinical Trial Saeko Imai, Shizuo Kajiyama, Yoshitaka Hashimoto, Chikako Yamane, Takashi Miyawaki, Neiko Ozasa, Muhei Tanaka, Michiaki Fukui PII: DOI: Reference:
S0168-8227(17)30133-X http://dx.doi.org/10.1016/j.diabres.2017.05.010 DIAB 6967
To appear in:
Diabetes Research and Clinical Practice
Received Date: Revised Date: Accepted Date:
23 January 2017 10 April 2017 8 May 2017
Please cite this article as: S. Imai, S. Kajiyama, Y. Hashimoto, C. Yamane, T. Miyawaki, N. Ozasa, M. Tanaka, M. Fukui, Divided Consumption of Late-Night-Dinner Improves Glycemic Excursions in Patients with Type 2 Diabetes: A Randomized Cross-over Clinical Trial, Diabetes Research and Clinical Practice (2017), doi: http:// dx.doi.org/10.1016/j.diabres.2017.05.010
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Divided Consumption of Late-Night-Dinner Improves Glycemic Excursions in Patients with Type 2 Diabetes: A Randomized Cross-over Clinical Trial
Saeko Imai a, Shizuo Kajiyama b, c, Yoshitaka Hashimoto c, Chikako Yamane d, Takashi Miyawaki a, Neiko Ozasa e, Muhei Tanaka c, and Michiaki Fukui c a
Department of Food and Nutrition, Kyoto Women’s University, Kyoto, Japan
b
Kajiyama Clinic, Kyoto, c Department of Endocrinology and Metabolism, Kyoto
Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan d
St. Mary’s Hospital, Himeji, Japan
e
Department of Cardiovascular Medicine, Kyoto University, Graduate School of Medicine,
Kyoto, Japan Corresponding author at Department of Food and Nutrition, Kyoto Women’s University, 35,Kitahiyoshi-cho, Imakumano, Higashiyama-ku, 605-8501, Kyoto, Japan E-mail address:
[email protected] (S. Imai)
Manuscript word count:2689
1
ABSTRACT Aims: To explore the acute effect of late-night-dinner and divided dinner on postprandial glucose levels in patients with type 2 diabetes. Methods: Sixteen patients were randomly assigned to this cross-over study. Each patient wore a continuous glucose monitor for 5 days and consumed identical test meals for 3 days. Patients consumed the test meals of dinner at 2100h (D21) or divided dinner (vegetable and rice at 1800h and the vegetable and the main dish at 2100h) on the second or fourth day, and dinner at 1800h (D18) on the third day. The daily glucose parameters were compared within-patient for 3 days. Results: D21 demonstrated significantly higher values of incremental area under the curve (IAUC) for glucose 2300 to 0800h (644 ± 156 vs. 147 ± 63 mmol/L×min, p
