A Randomized Study Comparing Three Cyclosporine-Based ...

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and azathioprine is still unclear. After initial therapy with cyclosporine and steroids,. 354 cadaver renal transplant recipients were randomly assigned at the post- ...
A Randomized Study Regimens in Cadaveric

Comparing Three Cyclosporine-Based Renal Transplantation

CLAUDIO PONTICELLI,* ANTONIO TARANTINO,* GIUSEPPE P. SEGOLONI,t VINCENZO CAMBI,# GAETANO RIZZO, PAOLO ALTIERI,111 FRANCESCO MASTRANGELO, MARCO CASTAGNETO,1 MAURIZIO SALVADORI,111 UMBERTO VALENTE, MARIA COSSU,tt STEFANO FEDERICO,** FRANCESCO PISANI,11 GIUSEPPE MONTAGNINO,* MARIA MESSINA,t LUCA ARISI,# MARIO CARMELLINI, GIANBENEDETTO PIREDDA,111’ and GIUSEPPE CORBETTA, for THE ITALIAN MULTICENTRE STUDY GROUP FOR RENAL TRANSPLANTATION (SIMTRe) *Djvisio,,e

Nefrologia

Giovanni Sperimentale,

Roma;

di Parma:

Nefrologia

e Dialisi,

Whether

steroids

(FP);

to treat

combined

with

and azathioprine

Nefnologia

renal

transplant After

rime alone

(monotherapy),

apy),

or cyclosporine

apy).

Monotherapy

switched

plus

to either

the

91%

graft

survival

the

therapy,

death

and

the pure

91 %,

respectively

(P

= not significant).

and

59 in triple

therapy,

52%

patients,

the

patients

in monotherapy,

therapy

(P

were 4-year

switched graft

the pure graft survival 94%, respectively, for alone. failure tion

Patients and (5 days

with

with after

low