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A road toward better education in personalized medicine at universities and beyond

Personalized medicine is likely to become a future direction of medicine. There is increased knowledge about gene functions in human health and disease and a rapid advance of biotechnologies. Personal genetic testing is available outside the medical room, as direct-to-consumer testing. There is concern about genetic literacy of general public and healthcare professionals which are to handle genetic results and their clinical interpretation. Education and training in personalized medicine and genetic/genomics/pharmacogenomics issues at different levels (high school, university, continuing medical education) is needed. Examples of innovated educational tools and curricula over the world are presented. The educational initiatives in the field of personalized medicine in the Czech Republic are followed from the very beginning. Keywords: education • genetics • genomics • personal genome testing • personalized medicine • pharmacogenomics

Personalized medicine is likely to be a future direction of healthcare. Rapidly increasing knowledge about human genes and their role in our health and diseases (an important milestone was the completion of the Human Genome Project in the year 2003) along with fast development of novel molecular tools and biotechnology methods such as oligonucleotide-based microarrays or next-generation sequencing supports this vision. The knowledge of our individual DNA, together with environmental factors, is supposed to enable more accurate predictions of whether an individual is developing an illness or will develop it in the future, or it now, will respond positively to treatment, or will suffer a serious adverse reaction to a drug [1] . In the light of these facts, clinicians and other healthcare providers should focus on the prevention, prediction of treatment effects, targeted care and screenings in order to earlier detect a disease, even before its manifestation. However, such shift from classical reactive medicine (treating symptoms) to the active approach to human

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health often fails to be promoted in the education of future healthcare specialists. Recently, many research activities focused on issues such as genetics, genomics, pharmacogenomics, discovery of new prediction and prognosis biomarkers, etc., are going on, and to date a number of success stories of implementation of personalized medicine, especially in oncology, have been reported (f.i., the use of the Her2/neu gene as a predictor of breast cancer patients’ responses to a drug called Herceptin) [2–4] . One important development is the rise of personal genome testing on the basis of genetic profiling: the testing of multiple genetic variants simultaneously for the prediction of common multifactorial diseases. The personal genome testing is available not only at the clinician’s prescription but has also become commercially available as direct-to-consumer testing and a number of companies (23 and Me, deCODE, Athleticode,…) offer the genome sequencing to the customers. The cost of sequencing a single human genome has dropped over

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Karlikova Marie*,1,2, Polivka Jiri Jr2,3, Strojil Jan4 & Topolcan Ondrej1 Laboratory of Immunoanalysis, Faculty of Medicine in Pilsen – Charles University in Prague & Faculty Hospital in Pilsen, E.Benese 13, 305 99 Pilsen, Czech Republic 2 Biomedical Center, Faculty of Medicine in Pilsen –Charles University in Prague, Alej Svobody 76, 323 00 Pilsen, Czech Republic 3 Department of Histology & Embryology, Faculty of Medicine in Pilsen – Charles University in Prague, Husova 3, 306 05 Pilsen, Czech Republic 4 Department of Pharmacology, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hnevotinska 3, 775 15 Olomouc, Czech Republic *Author for correspondence: Tel.: +420 377 401 121 Fax: +420 377 402 454 [email protected] 1

part of

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Review Marie, Jiri Jr, Jan & Ondrej the last decade from $100 million in 2001 to less than $10,000 in 2014 [5] and therefore genetic tests are getting more affordable. Such tests, however, often lack clinical validity and have problematic clinical utility and raise many questions concerning interpretation and proper counseling [6,7] . Consumers then consult the results with their physicians which, as studies suggest [8] , are ill-equipped for the role of preliminary genetic consultancy. There is growing concern about the genetic literacy of clinicians and how they will communicate information about personalized genomics to their patients [9,10] . In order to prepare society and especially healthcare professionals for the era of personalized medicine and genome testing, an educational requirement for different groups (high school students, medical students, healthcare professionals) has been expressed [9–11] . The aim of this paper is to point out the need of the education with the focus on students and healthcare professionals. Genetics & genomics for students & in continuing medical education Education in genetics is important already at the high school level since each individual should be able to make informed decisions about his or her own DNA on the basis of the knowledge about human genes, genotype and phenotype and their role in inheritance [12–14] . Studies demonstrated that general public and high school students often misunderstand basic genetic concepts [12,13,15,16] . These findings are troubling as it has been reported that such misconceptions influence how patients make decisions about genetic testing and treatment [17] . Since 2006, the American Society of Human Genetics annually organizes the National DNA Day Essay Contest intended to challenge students to examine, question and reflect on important concepts in genetics [15] . An analysis of a sample of 500 submitted essays, performed over years 2006 and 2007, found that several significant misconceptions about basic genetic concepts (such as ‘one gene is always responsible for one trait or one gene with one mutation always causes one disease’ or confusing ‘genetic’ with ‘hereditary’) could be identified in more than half of sampled essays. Several authors estimate that genetics curricula at high schools and universities are often out-of-date and do not prepare their students for the era of genetic testing [14,18,19] and call for the revision of curricula. A way to overcome this problem could be the integration of genetic education throughout the entire medical school curriculum [20,21] . Dhar et al. [21] described a novel elective Genetics Track Curriculum for all

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4 years of the undergraduate medical curriculum at Baylor College of Medicine to enhance genetic and genomic education. A particular example of innovation of a university course is reported by Redfield [19] . The ‘old’ second-year course in genetics (part of biology curriculum) followed classical textbooks with the history of genetics providing the organizing framework. Unfortunately, students finishing such course did not seem to understand much genetics. For instance, most students mistakenly believed that alleles are intrinsically either dominant or recessive, had no idea what makes one allele dominant to another. The author and collaborators have designed a new course leaving behind traditional but not really necessary topics (like Mendel’s laws and Punnett squares) and underlining topics and connections that students will need to know in the era of genetic testing (like personal genomics, natural genetic variation in populations and others). Moreover, according to the author, similar course design could be suitable as well for high school education in genetics. Similarly, Dougherty et al. [13] suggested a reorganization of genetic curricula by inverting the sequence of topics and emphasizing complex traits instead of the classical methods following historical consequences. However, the reorganization of lectures alone will probably not enhance students’ understanding of genetics and especially their motivation. Professor Robin Wright, the 2014 Awardee of the Genetics Society of America’s Elizabeth W. Jones Award for Excellence in Education, has transformed the undergraduate education of biology and genetics at the University of Minnesota into ‘doing biology’ classrooms and has a simple proposition for biology teachers: instead of preparing exhaustive lectures, teach as if the only thing that matters is what your students are able to do, or do better, at the end of the course than at the beginning [22] . Genomics is a young and quickly evolving area, so it is hard to anticipate either the genomic knowledge or the clinical application of that knowledge that will be common in the working years of today’s medical students and trainees [8] . It is the field of medicine that demands a lifelong learning. An important goal in educating healthcare professionals in genomics is to enable them to understand and utilize genetic-based probability and risk assessment, and to communicate effectively about them. Along with the activities of individual institutions, concerted efforts exist as well. In 2006, a set of core competences in genetics and genomics for the Europe was defined by the Education Committee of the European Society of Human Genetics and

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A road toward better education in personalized medicine at universities & beyond

other experts of the EuroGentest [23] . The proposed competences differ for different groups of healthcare professionals (general practitioners, nurses, medical specialist in fields other than genetics, specialist dentists) and provide a framework for genetics education of health professionals across national boundaries. The suggested learning outcomes are available to manage development of curricula that are applicable to the national context, educational system and healthcare setting of the professional involved. However, it depends on each nation how it will take responsibility for development of professional and educational standards in genetic healthcare that apply to local needs. Education of pharmacogenomics: need for medical students & physicians Pharmacogenomics, or its predecessor pharmacogenetics, have been a part of medical curricula in some sort for over half of a century, ever since difference in drug response based on genetic predisposition was first reported [23,24,25,26] . However, with the rapid expansion of pharmacogenetic and pharmacogenomic information in the recent decades it has become nearly impossible for physicians to keep up with current knowledge and for curricula to include all the possibly relevant information in their courses. The translation of pharmacogenomic information from the labs to bedside has been somewhat slow, ranging from clear and universal successes (trastuzumab and HER2/neu, imatinib and the Philadelphia chromosome, abacavir and HLA-B*5701) to intermediate progress (warfarin and CYP2C9 and VKORC1) to virtually no clinical relevance in daily practice (statins and SLCO1B1 polymorphism). A study performed in the USA by the American Medical Association surveyed over 10,000 doctors and found that a vast majority of them (98%) believed patients’ genetic makeup affects pharmacotherapy, yet only 10% felt educated enough to feel comfortable adopting this genetic information in their patient practice [27] . Other surveys have confirmed these results, with oncologists reporting being better informed about advances in personalized therapy and only about 50% of recent graduates having received any training in genomic-based therapy; this number decreased for graduates from more than 5 years ago [28,29] . The conclusion of these and other studies was similar: most doctors see molecular tests as an important an asset in patient care, however, a minority of surveyed doctors feel up to date on genetic tests and feel very familiar and confident with current findings in genomics – it can be called an ‘awareness–information gap.’ Moreover, a distinct


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difference exists in baseline awareness, knowledge and adoption between oncologists, cardiologists and primary care physicians. The education should be provided with respect to these differences, instead of one-fits-to-all approach [29] . Many schools now include instruction on pharmacogenomics either as part of basic and/or clinical pharmacology courses, or as a stand-alone elective course in their medical doctor (MD) program [30,31,32] . Pharmacy schools have had a certain head start on medical schools in implementing pharmacogenomics information in their curricula as compared with medical curricula which is overcrowded by an increasing body of information in which pharmacotherapy and prescribing is just one part competing for time and resources. Reports on pharmacists’ confidence in pharmacogenomic prescribing are similar to those in physicians mentioned above [34,33] . With the increasing number of drugs that need to be taught to students and therapy getting more fragmented as treatment gets more personalized, teaching of pharmacology and pharmacogenomics will face a problem of selecting only the most relevant (and future-proof ) pharmacogenomic information to include in instruction of all medical students. Details on specific drugs relevant to particular medical specializations will be a vital component of continuing medical education for which a medical graduate should come prepared with understanding of pharmacogenomics concepts and most relevant examples that illustrate them. Personal genetic testing: learning by doing An efficient way to increase students’ motivation and encourage learning of genetics and genomics can be to provide them with their own practical experience with personal genetic testing [34–36] . Several academic institutions in the USA, mainly with the support of commercial direct-to-consumer providers, have considered offering courses for medical students including personal genetic testing and published their experiences and recommendations. A positive experience was reported by Sansgiry and Kulkarni [34] from the Stanford School of Medicine (CA, USA). In the elective course GENE 210 [36] , students used personal genotype data in the classroom; testing was voluntary and anonymous. According to the survey among participating students, this experience enhanced their self-reported and assessed knowledge of genomics, and did not appear to cause significant anxiety. To evaluate students’ attitude toward personal genetic testing as an educational tool, Vernez et al. [37]

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Review Marie, Jiri Jr, Jan & Ondrej conducted individual interviews with students who chose to undergo personal genotyping in the context of an elective genetics course. Overall, students stated that personal genotyping enhanced their engagement with the course content, although they expressed skepticism over the clinical utility of some of the test results. At the same time, students did not report utilizing genetic counseling, despite feeling strongly that the ‘general public’ would need these services. The authors concluded with the recommendation that before incorporating personal genotyping into coursework, institutions should lead multidisciplinary discussion to anticipate issues and incorporate teaching mechanisms that engage the ethical, legal, and social implications of personal genotyping. Boguski et al. [38] added a suggestion that specialists with expertise in clinical laboratory tests should be included as members of multidisciplinary curriculum development and delivery teams to assure the preanalytical and analytical issues of the test results. An analysis on the ethical concern raised by the educational genotyping was published by Callier et al. [39] . The publication lists several educational DNA testing initiatives and considers them in terms of who performs the testing (e.g., a commercial laboratory, university laboratory or classroom laboratory instructor), the format for returning results, the number of single-nucleotide polymorphisms tested, and the scope and goals of different lessons. The authors underline the benefits of educational DNA testing together with pointing out that students should receive information on the ethical issues and the risks associated with genetic testing. Ethical, legal & social issues It is increasingly important that physicians have a thorough understanding not only of the basic science of human genetics and genomics but also of the ethical, legal and social implications associated with genetic testing and counseling. As has been already suggested, physicians will often be the first healthcare professionals to advise patients about genetic testing or assist with result interpretation. Due to the demanding curriculum requirements of medical schools and the need for medical students to complete many courses, adding extra courses to the medical school curriculum can be difficult. A possible solution is the development of supplemental course modules that can then be accessed online. Metcalf et al. [40] developed a series of interactive web-based courses including clinical case studies for medical students on these topics. A pilot trial of the courses indicated that the courses have a statistically significant positive effect on knowledge, attitude,

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intended behavior and self-efficacy related to genetic testing. However, we do not yet know the long-term effects of these modules on medical student knowledge and behavior. Examples of education at academic institutions & national levels Over the world, especially in the North America and the Europe, a number of universities already offer undergraduate and graduate education in genomics, pharmacogenomics, molecular medicine or simil21ar topics, in some of which personalized medicine is also discussed. Programs dedicated to personalized medicine exist at the Duke University (NC, USA) [41] and at Mount Sinai School of Medicine (NY, USA). Mount Sinai School of Medicine was the first university to offer to the students the possibility of personal sequencing of the whole genome [42] . Also, some medical schools have updated their curricula by including genomic medicine, such as Harvard Medical School (MA, USA). The University of California, San Francisco Medical School, launched in 2001 a graduate PhD program in Pharmaceutical Sciences and Pharmacogenomics [43] . At the Tel Aviv University Faculty of Medicine (Tel Aviv, Israel), pharmacogenetics has been incorporated to the MD teaching curriculum since 2001 and offered as an elective class for graduate students since 2003 [31] . The education for health professionals is provided by the Golden Helix Institute (Greece) [44] . At the Karolinska Institute (Sweden) there is a master program in molecular medicine, and at the University of Bonn (Germany) an International Masters Course in Molecular Biology and Biotechnology is going on . Some of the courses are designed for e-learning, for example, the US National Coalition for Health Professional Education in Genetics [45] has developed a series of web-based medical education programs discussing the influence of genetics on various diseases. Similarly, in the UK the national genetics education and development center [46] has developed evidence-based learning objectives and competencies in genetics for health professionals. In Europe, at least two associations are involved in the education in personalized medicine: the European Association for Predictive, Preventive and Personalized Medicine (EPMA) [47,48] which publishes a series of educational books, and the European Personalized Medicine Association (EPEMED) which together with EuroBioForum offers Education and Training in Personalized Medicine for Healthcare Professionals in the form of webinars [49] .



First steps: experience from the Czech Republic A Chinese proverb says that ‘a journey of a thousand miles begins with a single step.’ A journey toward the education in personalized medicine in the Czech Republic has also begun with few steps or, more precisely, with few activities conducted by few enthusiastic people. Most research and educational activities in the area of personalized medicine are concentrated at the Charles University of Prague – the Faculty of Medicine in Pilsen and the Faculty Hospital in Pilsen [50] . Since 2007, lectures and workshops on personalized medicine for healthcare professionals and medical students have been included in the program of the international congress Immunoanalytical Days and CECHTUMA [51] , organized every year under the auspices of the Charles University – the Faculty of Medicine in Pilsen and the Faculty Hospital in Pilsen. At the beginning, these lectures were provided by invited experts from the USA; recently Czech researchers and academics report their growing experience with personalized medicine. Additional conferences focused on the application of personalized medicine in different clinical specializations take place every year. In June 2014, professionals from the Faculty of Medicine in Pilsen had an honor to co-organize the third International Congress on Personalized Medicine Up Close and Personalized in Prague [52] . In 2010, a working group of professionals was established at the Faculty of Medicine in Pilsen with the goal to implement principles of personalized medicine into the undergraduate and postgraduate educa-

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tion. They assessed, with the help of a survey questionnaire, the awareness about personalized medicine among medical students. The ‘Personalized Medicine Questionnaire’ was prepared and addressed to fourthyear medical students; 80 responders were involved. Students had to answer nine nominal questions. The summary of the average of responses for each question is presented in Table 1. As the results of the questionnaire imply, the awareness about personalized medicine among students is quite weak (more than 39% have not even heard the term ‘personalized medicine’), although most students (more than 75%) recognize the importance of personalized medicine and would welcome its implementation into the medical education [53] . In the frame of several EU-funded projects, several elective courses were introduced in undergraduate and graduate curricula of the Faculty in 2012. Examples of courses are presented in Figure 1. In the region of Olomouc, the institute of molecular and translational medicine was opened as part of the program biomedicine for regional development and human resources (BioMedReg), financed by European regional development fund (ERDF) and the national budget through the operational programme for research and development for innovation. The Institute serves primarily as a research center with ties to the University hospital providing personalized medicine services and diagnostics to patients, but is also involved in teaching at both graduate and postgraduate level. Since 2011, the institute is involved in the European social fund project managed by the department of pharmacology which coordinates 13 different

Table 1. Summary of the responses for each question in the personalized medicine questionnaire (scoring 1–5, 1 = not at all; 5 = definitely yes). Question

Average value (n = 80)

Have you ever heard the term ‘personalized medicine’?

2.26

Would you be able to explain, what does the ‘personalized medicine’ mean?

2.36

Do you consider ‘personalized medicine’ to be important?

4.16

Do you think ‘personalized medicine’ should be studied as an independent discipline or through the various disciplines separately?

3.16

Do you consider the role of ‘personalized medicine’ will increase with the progress of knowledge?

4.2

Is tuition in ‘personalized medicine’ sufficient in pregraduate education in medical school?

1.85

Do you think ‘personalized medicine’ should be implemented into the undergraduate education of medicine for all students?

3.66

Do you think ‘personalized medicine’ should be implemented into the education of medicine as a required course?

4.14

Will you choose the course of ‘personalized medicine’?

3.84



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Study program

Year of the study

New elective courses in personalized medicine

First

Methods for determining gene expression

Second

Pathology of the individual’s tumor microenvironment Principles of immunoassays and their applications

Third General medicine Fourth

New aspects of tumor pathobiology Personalised medicine – fiction or future of the medicine Targeted therapy in oncology

Fifth

Sixth

Utilization of tumor markers for prognosis and prediction of neoplastic diseases Complex stroke care – the approach of personalised medicine

Figure 1. Examples of elective courses in personalized medicine at the Faculty of Medicine in Pilsen.

departments in an effort to update and improve teaching of personalized and laboratory medicine in the curriculum. The aims of the project are both to provide support for updating and innovating course materials of traditional ‘core’ subjects, from basic sciences such as biology to clinical subjects such as internal medicine or even surgery. The aim is to include up-to-date information on predictive and personalized medicine so that students are equipped for modern clinical practice once they graduate. In another part of the project, over 20 new elective courses were introduced into the curriculum of the faculty of medicine in Olomouc, aimed to provide students interested in individual subjects in more detail (the most important courses are listed in Table 2) . These courses received a positive student response in the evaluation, performed by the instructor at the end of the academic year (78% of students rated the courses like ‘very useful’ and ‘rather useful’). Most of them (65%) appraised the focus on practical applications and correct and rational indication and interpretation of individual tests, rather than on technical

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details of methods. Students, especially in 4th and 5th grades with more clinical exposure, realize their future role as users, rather than direct executors, of these tests. At both faculties of medicine, the students’ participation, evaluation and motivation to complete the courses in the field of personalized medicine are continuously monitored and it is anticipated that several courses will be included in the MD curricula as required ones. The authors envisage that the course portfolio could serve as a model for other academic institutions at national level. Conclusion Academic and other institutions proceed in the changes in their educational curricula toward genetics and genomics, and the implementation of new models and curricula takes place gradually. Different tools have been described and applied, from innovated programs and lectures to practical training through personal genetic testing. Cooperation and exchange of experiences between institutions is crucial for an efficient implementation of



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Table 2. Selected list of new elective courses introduced as part of an European social fund project in the curriculum of the Faculty of Medicine in Olomouc, Czech Republic. Year of study

Extent (h)

Title

4–6

10

Interpretation of microbiology tests in clinical medicine

4–6

15

Molecular-biology methods in microbiology and their limitations

2–6

7

Predictive methods in pathology

4–6

15

Epigenetics in oncology

4–6

8

Immunology monitoring in medicine

4–6

8

Immunology in transplant medicine

4–6

15

Interpretation of coagulation tests and management of anticoagulation

4–6

8

Case reports in laboratory medicine

4–6

9

‘-omics’ in medicine

4–6

9

Animal models and their use in medicine

4–6

15

Laboratory medicine

these tools. A support from educational organizations on the national level is important as well. Future perspective It is anticipated that in the next 5–10 years the knowledge in the field of genomics and pharmacogenomics, together with rapid advances in biotechnologies and will increase, together with the availability of personal genetic testing. At the same time, general public’s awareness about genetic testing will grow, most probably also through

media and commercial adds, and the role of physicians and other healthcare professionals as first hand ‘counselors’ will be more pronounced. The implementation of genetic data into individual’s healthcare record will continue and healthcare specialists will face the necessity to get familiar with these data. More coordinated revisions of medical curricula and cooperation between academic institutions and other institutions (national societies, companies) are critical to assure competent healthcare professionals for the era of personalized medicine.

Executive Summary Background • Healthcare professionals are not fully prepared to the era of personalized medicine; they often lack appropriate education and training at universities.

Genetics & genomics for high school & medical students & in continuing medical education • All individuals should have knowledge of basic genetic principles in order to be able to make decisions concerning her/his own DNA. • Many students show misconceptions in basic genetic concepts, the classes are not up-to-date. • Innovation lies in the revised classes and more practical work.

Education of pharmacogenomics: need for medical students & physicians • Physicians are aware of the importance of pharmacogenomics, however they lack sufficient knowledge. • Universities are incorporating pharmacogenomics in their curricula and it is not always easy since the medical curricula are overcrowded.

Personal genetic testing: learning by doing • Several universities offer personal genetic testing as an educational tool, they reported a positive experience like enhanced students, motivation. • Discussions are going on about ethical, societal and legal issues as well as about the analytical performances of such classroom tests.

Ethical, legal & social issues • There is need to include ethical, legal and social issues of genetic testing into the curricula.

Examples of education at academic institutions • A number of examples of innovated academic programs and courses are reported.

First steps: experience from the Czech Republic • Faculty of Medicine in Pilsen and Faculty of Medicine in Olomouc are the most active subjects in implementing personalized medicine in university curricula. • A survey was held to assess students’ awareness and interest in personalized medicine. • Seminars, conferences and innovative courses are ongoing.



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Review Marie, Jiri Jr, Jan & Ondrej Acknowledgments The authors Karlikova M, Polivka J Jr and Strojil J contributed equally to the manuscript preparation. Topolcan O provided valuable advices and comments.

Financial & competing interests disclosure The review study was supported by the project ED2.1.00/03.0076 from the European Regional Development

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Fund and by Ministry of Health, Czech Republic - conceptual development of research organization (Faculty Hospital in Pilsen – FNPl, 00669806). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

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Rich resource of freely accessible educational programs in genetic medicine.

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Sansgiry SS, Kulkarni AS. Genetic testing: the community pharmacist’s perspective. J. Am. Pharm. Assoc. 44(3), 399–402 (2004).

Lemke HU, Golubnitschaja O. Towards personal health care with model-guided medicine: long-term PPPM-related strategies and realisation opportunities within ‘Horizon 2020’. EPMA J. 5(1), 8 (2014).

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Salari K, Karczewski KJ, Hudgins L, Ormond KE. Evidence that personal genome testing enhances student learning in a course on genomics and personalized medicine. PLoS ONE 8(7), e68853 (2013).

EPMA – The European Association for Preventive, Predictive and Personalised Medicine. www.epmanet.eu

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EPEMED – The European Personalised Medicine Association. www.epemed.org

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EuroBioForum – Personalized Medicine Obsevatory. www.eurobioforum.eu

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Practical experience from the Stanford University (USA) where the personal genetic testing was adopted as an educational tool.

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GENE210 – Genomics and Personalized Medicine. http://web.stanford.edu

International Conference Immunoanalytical Days. www.imunodny.eu

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Vernez SL, Salari K, Ormond KE, Lee SS. Personal genome testing in medical education: student experiences with genotyping in the classroom. Genome Med. 5(3), 24 (2013).

UPCP 2014. The 3rd International Congress on Personalized Medicine. http://2014.upcp.org

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Boguski MS, Boguski RM, Berman MR. Personal genotypes are teachable moments. Genome Med. 5(3), 22 (2013).

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Callier SL. Swabbing students: should universities be allowed to facilitate educational DNA testing? Am. J. Bioeth. 12(4), 32–40 (2012).

Polivka J Jr, Karlikova M, Polivka J, Kinkorova J, Topolcan O. Personalized medicine – pre- and postgraduate education in the Czech Republic. In: Proceedings of the 2nd International Congress on Personalized Medicine UPCP. Paris, France, 25–28 July 2013. Karnieli E, Rishe N, Yesha Y (Eds). Medimond, Bologna, Italy (2014).



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