1750
Research Article
A spatially restricted increase in receptor mobility is involved in directional sensing during Dictyostelium discoideum chemotaxis Sandra de Keijzer1,2, Arnauld Sergé1, Freek van Hemert1, Piet H. M. Lommerse1,2, Gerda E. M. Lamers2, Herman P. Spaink2, Thomas Schmidt1,* and B. Ewa Snaar-Jagalska2,* 1
Physics of Life Processes, Leiden Institute of Physics, Leiden University, Niels Bohrweg 2, 2333 CA Leiden, The Netherlands Cell Biology, Leiden Institute of Biology, Leiden University, PO Box 9504, 2300 RA Leiden, The Netherlands
2
*Authors for correspondence (e-mails:
[email protected];
[email protected])
Journal of Cell Science
Accepted 25 February 2008 Journal of Cell Science 121, 1750-1757 Published by The Company of Biologists 2008 doi:10.1242/jcs.030692
Summary The directed cell migration towards a chemotactic source, chemotaxis, involves three complex and interrelated processes: directional sensing, cell polarization and motility. Directional sensing allows migrating eukaryotic cells to chemotax in extremely shallow gradients (
