AAPS, Lagos, Nigeria, 5-8 September, 2016

Abstracts of the Proceedings of the 7th International Congress of AAPS, Lagos, 5-8 September, 2016

Abstracts of Proceedings of the 7th International Congress of the AAPS, Lagos, Nigeria, 5-8 September, 2016 Artesunate-mefloquine combination induces oxidative stress and deranges hepatic histology. Aluko, E.O., Olatunbosun, T.H. and Atang, D.E. Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Akwa-Ibom State, Nigeria. The resistance of malaria to anti-malaria drugs necessitated the need to bring forth new therapies to avert the resistance; one of these is the combination therapy (WHO, 2005). The individual drug particularly mefloquine have been reported to have low tolerance effects (Jhas and kumar, 2006). This study was therefore setup to investigate the oxidative and hepatic histomorphological effect of artesunate-mefloquine combination therapy in rats. Female wistar rats (150-180g, n=10) were randomly divided into two groups designated control (2.5ml of distilled water), and artesunate-mefloquine group (22.5ml/kg of artesunate-mefloquine combination). All groups had access to food and water ad libitum, and the drug was orally administered for 28 days. After 28 days, the rats were anaesthetized with urethane and chloralose intraperitioneally at a dose of 5ml/kg and blood sample was drawn via cardiac puncture for estimation of serum levels malondialdehyde and antioxidant enzymes. The animals were euthanized by cervical dislocation, and the liver was excised for histological analysis. There was a significant increase in malondialdehyde level in the artesunate-mefloquine group compared to the control group (p