Nov 17, 2013 - 128 (10022): A17434 -- Circulation. Page 1 of 1 http://circ.ahajournals.org/cgi/content/meeting_abstract/128/22_MeetingAbstracts/A17434.
Abstract 17434: Simple Renal Cysts as Predictors of Thoracic Aortic Disease -- Ziganshin et al. 128 (10022): A17434 -- Circulation
17/11/13 8:45 AM
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Core 7. Vascular Disease: Biology and Clinical Science Session Title: Risk Factors and Systemic Mediators of Atherosclerosis
Abstract 17434: Simple Renal Cysts as Predictors of Thoracic Aortic Disease Bulat A Ziganshin; Panagiotis Theodoropoulos; Mohammad N Salloum; Khaled J Zaza; Maryann Tranquilli; John A Elefteriades Aortic Institute, Yale Univ Sch of Medicine, New Haven, CT
Thoracic aortic diseases (TAD), namely aneurysm and dissection, are usually clinically silent, so that the first symptom is often either death or a lifethreatening complication. Several medical conditions such as bicuspid aortic valve, intracranial aortic aneurysm, and family history of TAD have all been associated with an increased risk of developing a TAD in the patient. The aim of our study was to evaluate the prevalence of simple renal cysts (SRC) in patients with TAD in order to assess the hypothesis that the presence of SRC can be used as a predictor for development of TAD. We evaluated the prevalence of SRC in patients with TAD (n=842, 539 males, 303 females, mean age 63.5 ± 14.2) undergoing treatment at our institution during the period 2004-2013. The patients were divided into four groups: ascending aortic aneurysm (456, 54.2%), descending aortic aneurysm (86, 10.2%), Type A aortic dissection (118, 14.0%), and Type B aortic dissection (182, 21.6%). The prevalence of SRC was determined by analyzing the reports of computed tomography imaging of the chest and abdomen of these patients. The results of our study are presented in the Table. We found that the prevalence of SRC is 37.1%, 57.0%, 44.1%, and 46.7% for patients with ascending, descending aortic aneurysm, Type A, and Type B aortic dissection, respectively. These numbers are considerably greater than expectations for the overall prevalence of SRC for the general public (range 10% to 14% in recent reports). In addition, the prevalence of SRC was not significantly different between males and females (p>0.05), despite the reported male predominance for the general population (2:1 male:female ratio). In conclusion, in this study we established an increased prevalence of SRC in patients with TAD. These results are suggestive that SRC can potentially be used as a marker for timely detection of patients at risk of developing TAD.
Author Disclosures: B.A. Ziganshin: None. P. Theodoropoulos: None. M.N. Salloum: None. K.J. Zaza: None. M. Tranquilli: None. J.A. Elefteriades: Research Grant; Significant; Medtronic grant to Yale. Expert Witness; Significant; For defendant. Consultant/Advisory Board; Significant; Datascope, Covidien. Other; Significant; Shareholder in start-up CoolSpine.
Key Words: Aortic diseases • Renal function • Risk factors
http://circ.ahajournals.org/cgi/content/meeting_abstract/128/22_MeetingAbstracts/A17434
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