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The Multimodal Antidepressant Vortioxetine Restores Cognitive Function in. Preclinical Models Across Several Cognitive Domains. Connie Sanchez1, Alan L.
The Multimodal Antidepressant Vortioxetine Restores Cognitive Function in Preclinical Models Across Several Cognitive Domains Connie Sanchez1, Alan L. Pehrson1, Yan Li1, Nasser Haddjeri2, Maria Gulinello3, Francesc Artigas4

0

Vehicle

2.5

5

10

Vortioxetine (mg/kg)

50

chance

25 0

1

Vehicle

2.5

5

10

Vortioxetine (mg/kg)

Donepezil (mg/kg)

**p90

Control

PCPA Escitalopram Duloxetine Vortioxetine 0.5 mg/kg 15 mg/kg 10 mg/kg

95

Denotes significant differences from control; * Denotes significant differences from PCPA. p