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Nasiri
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Home > Iranian and International Congress of Micorbiology > The 13th Iranian & The Second International Congress of Microbiology > Drug Resistance > Nasiri Font Size: Increasing Prevalence of Antimicrobial Resistance Among Clinical Alcaligenes Species Isolates from Imam Khomeini Hospital in Tehran, Iran Mohammad Javad Nasiri, Samin Zamani, Behshad Noorazar Khoshgnab, Fereshteh Rezagholizadeh, Azin Zamani, Alireza Abdollahi Last modified: 2012-06-26
Abstract Background & Objactives: Alcaligenes species have been isolated from various environmental and hospital water sources and also from clinical specimens, including blood, urine, stool and sputum. Alcaligenes spp. are often associated with serious infections such as fatal bacteremia, pneumonia, urinary tract infections, endocarditis and otitis externa. Members of the this genus are usually susceptible to antibiotics commonly used in treatment of infections, but increasing rates of antimicrobial resistance among clinical Alcaligenes spp. isolatesis a growing concern.The aim of this study was to determine the prevalence and antimicrobial susceptibility of Alcaligenes spp. from blood samples. Method: A total of 820 blood specimens were collected from Imam Khomeini hospital in Tehran,during a 1 year period from March 2010 to February 2011. All samples were analyzed for isolation and identification of bacteria. Antimicrobial resistance pattern to different antimicrobial agents were also performed using disk diffusion method. Results: 195(23%) Alcaligenes spp. isolate from blood sample identified. All the isolates were susceptible to Ciprofloxacin and Co-trimoxazole. Also high susceptibility rates to Imipenem (94%) and Gentamicin (89%) were documented. Resistance of Alcaligenes spp. to other antibiotics was as follow: Ceftriaxone (60%), Ampicillin/sulbactam (39%), Ceftazidime (33%), Amikacin (29%) and Piperacillin- sulbactam (25%). Conclusion: Further studies are needed to standardize microbiologic methodologies for susceptibility testing of Alcaligenes spp. However the antimicrobial susceptibility profile of Alcaligenes spp. demonstrated that this organism is highly susceptible to Ciprofloxacin, Co-trimoxazole, Imipenem and Gentamicin. Also, according to this study, antimicrobial resistance to Ceftriaxone, Ampicillin/sulbactam, Ceftazidime, Amikacin and Piperacillin- sulbactam is increasing among Alcaligenes spp isolates. Therefore antimicrobial therapy against this uncommon opportunistic pathogenes should be performed by an awareness of its antimicrobial susceptibility profile.
Keywords Alcaligenes Species, Antimicrobial Resistance, Susceptibility, Imam Khomeini Hospital
References 1-Knippschild M, Schmid EN, Uppenkamp M, König E, Meusers P, Brittinger G, et al. Infection by Alcaligenes xylosoxidans subsp. Xylosoxidans in neutropenic patients. Oncology. 1996;53:258–62. 2- Vu-Thien H, Darbord JC, Moissenet D, Dulot C, Dufourcq JB, Marsol P, et al. Investigation of an outbreak of wound infections due to Alcaligenes xylosoxidans transmitted by chlorhexidine in a burns unit. Eur J Clin Microbiol Infect Dis. 1998;17:724–6. DOI: 10.1007/ s100960050168 3- Tsay RW, Lin LC, Chiou CS, Liao JC, Chen CH, Liu CE, et al. Alcaligenes xylosoxidans bacteremia: clinical features and microbiological characteristic of isolates. J Microbiol Immunol Infect. 2005;38:194–9. 4- Murray PR, Baron EJ, Jorgensen JH, Landry ML, Pfaller MA, eds. Manual of clinical microbiology. 7th ed. Washington: American Society for Microbiology; 1999. file:///C:/Documents%20and%20Settings/MIC/Desktop/Nasiri.html
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2/8/2016
Nasiri
Track: Drug Resistance Session Type: Poster
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