Abstract : The beta-catenin and adenomatous polyposis coli (APC ...

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study, we investigated nuclear beta-catenin accumulation and mutations of beta-catenin and APC in 48 gastric adenomas and 59 early differentiated-type.
1)

Showa

Univ

J

Med

Sci

18(2),

83•`91,

June

2006

Original

Nuclear

Beta-catenin

Beta-catenin

and

Accumulation APC

Tumors

Masaaki Nobukazu

in Early of the

and

Mutations

Differentiated-type

Stomach

SAKAMOTO1), Yusuke

TAJIMA1), Reiko

MAKINO2),

NISHINO1), Shigeo

AOKI1), Masanori

KATO1),

Koji MOROHARA1), Kimiyasu and

YAMAZAKI1), Tsutomu

Mitsuo

of

KAETSU1)

KUSANO1)

Abstract : The beta-catenin and adenomatous polyposis coli (APC) genes are important in tumorigenesis of gastrointestinal neoplasms. Accumulation of beta-catenin in the nucleus due to mutations in beta-catenin and / or APC has been associated with early tumorigenesis in colorectal tumors. In this study, we investigated nuclear beta-catenin accumulation and mutations of beta-catenin and APC in 48 gastric adenomas and 59 early differentiated-type adenocarcinomas. Widespread or focal nuclear expression of beta-catenin was found in 14 (29.2%) gastric adenomas and 18 (30.5%) differentiated-type carcinomas. Mutations in beta-catenin were detected in only one case of gastric adenoma, while APC was mutated in 17 (35.4%) of the gastric adenomas and 11 (18.6%) early differentiated-type carcinomas. The accumulation of nuclear beta-catenin was significantly more prevalent in tumors with APC mutations than in those without APC mutations (67.9% vs 16.5%, p