study, we investigated nuclear beta-catenin accumulation and mutations of beta-catenin and APC in 48 gastric adenomas and 59 early differentiated-type.
1)
Showa
Univ
J
Med
Sci
18(2),
83•`91,
June
2006
Original
Nuclear
Beta-catenin
Beta-catenin
and
Accumulation APC
Tumors
Masaaki Nobukazu
in Early of the
and
Mutations
Differentiated-type
Stomach
SAKAMOTO1), Yusuke
TAJIMA1), Reiko
MAKINO2),
NISHINO1), Shigeo
AOKI1), Masanori
KATO1),
Koji MOROHARA1), Kimiyasu and
YAMAZAKI1), Tsutomu
Mitsuo
of
KAETSU1)
KUSANO1)
Abstract : The beta-catenin and adenomatous polyposis coli (APC) genes are important in tumorigenesis of gastrointestinal neoplasms. Accumulation of beta-catenin in the nucleus due to mutations in beta-catenin and / or APC has been associated with early tumorigenesis in colorectal tumors. In this study, we investigated nuclear beta-catenin accumulation and mutations of beta-catenin and APC in 48 gastric adenomas and 59 early differentiated-type adenocarcinomas. Widespread or focal nuclear expression of beta-catenin was found in 14 (29.2%) gastric adenomas and 18 (30.5%) differentiated-type carcinomas. Mutations in beta-catenin were detected in only one case of gastric adenoma, while APC was mutated in 17 (35.4%) of the gastric adenomas and 11 (18.6%) early differentiated-type carcinomas. The accumulation of nuclear beta-catenin was significantly more prevalent in tumors with APC mutations than in those without APC mutations (67.9% vs 16.5%, p
