Diabetologia (2005) 48: 2501–2504 DOI 10.1007/s00125-005-0033-2
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I. Knerr . J. Wolf . T. Reinehr . R. Stachow . M. Grabert . E. Schober . W. Rascher . R. W. Holl . on behalf of the DPV Scientific Initiative of Germany and Austria
The ‘accelerator hypothesis’: relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9,248 German and Austrian children with type 1 diabetes mellitus Received: 21 April 2005 / Accepted: 14 July 2005 / Published online: 11 November 2005 # Springer-Verlag 2005
Abstract Aims/hypothesis: The aim of this study was to investigate whether either increased weight or BMI are associated with the earlier manifestation of type 1 diabetes mellitus in children. Methods: We evaluated anthropometric measurements in a large cohort of 9,248 patients of European extraction who were diagnosed in the years 1990–2003 in 116 pediatric clinics throughout Germany and Austria. Results: Patients were divided into four groups according to age (0–4.9 years, 5–9.9 years, 10– 14.9 years and 15–20 years). Significantly higher standard deviation scores (SDSs) for weight and BMI at diabetes Electronic supplementary material Supplementary material is available for this article at http://dx.doi.org/10.1007/s00125-0050033-2 and accessible for authorised users. I. Knerr (*) . W. Rascher University Children’s Hospital, University of Erlangen-Nuremberg, Loschgestr.15, 91054 Erlangen, Germany e-mail:
[email protected] Tel.: +49-9131-8533118 Fax: +49-9131-8533113 J. Wolf St Vincenz Children’s Hospital, Paderborn, Germany T. Reinehr Vestische Hospital for Children and Adolescents, University of Witten-Herdecke, Datteln, Germany R. Stachow Clinic for Children and Adolescents, Sylt, Germany M. Grabert . R. W. Holl Department of Epidemiology, University of Ulm, Ulm, Germany E. Schober University Children’s Hospital, Vienna, Austria
onset were found for both boys and girls in the three younger age groups (up to 14.9 years of age) compared with the reference population (p
