Accepted Manuscript Analysis of Preoperative Metabolic Risk Factors Affecting the Prognosis of Patients with Esophageal Squamous Cell Carcinoma: The Fujian Prospective Investigation of Cancer (FIESTA) Study
Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Hejun Zhang, Xiaoqun Dong, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu PII: DOI: Reference:
S2352-3964(17)30039-7 doi: 10.1016/j.ebiom.2017.01.035 EBIOM 939
To appear in:
EBioMedicine
Received date: Revised date: Accepted date:
7 December 2016 14 January 2017 25 January 2017
Please cite this article as: Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Hejun Zhang, Xiaoqun Dong, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu , Analysis of Preoperative Metabolic Risk Factors Affecting the Prognosis of Patients with Esophageal Squamous Cell Carcinoma: The Fujian Prospective Investigation of Cancer (FIESTA) Study. The address for the corresponding author was captured as affiliation for all authors. Please check if appropriate. Ebiom(2017), doi: 10.1016/j.ebiom.2017.01.035
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ACCEPTED MANUSCRIPT
Research Paper Analysis of Preoperative Metabolic Risk Factors Affecting the Prognosis of Patients with Esophageal Squamous Cell Carcinoma: The Fujian
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prospective investigation of cancer (FIESTA) study
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Feng Penga,*, Dan Hub,*, Xiandong Linb, Gang Chenb, Binying Liangc , Hejun
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Zhangb, Xiaoqun Dongd, Jinxiu Lina,#, Xiongwei Zhengb,#, Wenquan Niue,#
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Author Affiliations: a
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Department of Cardiology, The First Affiliated Hospital of Fujian Medical
University, Fuzhou, Fujian, China b
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Department of Pathology, Fujian Provincial Cancer Hospital, The Affiliated
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Hospital of Fujian Medical University, Fuzhou, Fujian, China Department of Medical Record, Fujian Provincial Cancer Hospital, The
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Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China Department of Gastroenterology, Stephenson Cancer Center, Department of
Internal Medicine, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma city, OK, USA e
State Key Laboratory of Medical Genomics, Rui Jin Hospital, School of
Medicine, Shanghai Jiao Tong University, Shanghai, China. *Shared first authors.
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Correspondence should be addressed to:
Wenquan Niu, Ph.D.: Address: Rui Jin Second Road 197, Huang Pu District, Shanghai 200025, China. Phone: +86-21-64370045 ext. 610905. Fax: +86-21-64333548. E-mail:
[email protected] or
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Xiongwei Zheng, M.D. Ph.D.: Address: Fu Ma Road 420, Jin An District,
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Fuzhou 350014, Fujian, China. Phone: +86-591-8364 3149. Fax:
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+86-591-8392 8767. E-mail:
[email protected] or
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Jinxiu Lin, M.D. Ph.D.: Address: Chazhong Road 20, Taijiang District, Fuzhou 350005, Fujian, China. Phone: +86-591-8798 1637. Fax: +86-591-8798 1635.
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E-mail:
[email protected].
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Short Title: Metabolic Risk Factors & ESCC Prognosis
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Word Counts: 244 (Abstract); 4310 (Full manuscript).
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ACCEPTED MANUSCRIPT ABSTRACT Some metabolic factors have been shown to be associated with an increased risk of esophageal cancer; however the association with its prognosis is rarely reported. Here, we assessed the prediction of preoperative metabolic
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syndrome and its single components for esophageal cancer mortality by
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analyzing a subset of data from the ongoing Fujian prospective investigation of
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cancer (FIESTA) study. Between 2000 and 2010, patients who underwent three-field lymphadenectomy were eligible for inclusion. Blood/tissue
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specimens, demographic and clinicopathologic data were collected at baseline.
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Metabolic syndrome is defined by the criteria proposed by Chinese Diabetes Society. In this study, analysis was restricted to esophageal squamous cell
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carcinoma (ESCC) due to the limited number of other histological types. The
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median follow-up in 2396 ESCC patients (males/females: 1822/574) was 38.2 months (range, 0.5-180 months). The multivariate-adjusted hazard ratio (HR)
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of metabolic syndrome for ESCC mortality was statistically significant in males (HR, 95% confidence interval, P: 1.45, 1.14-1.83, 0.002), but not in females (1.46, 0.92-2.31, 0.107). For single metabolic components, the multivariate-adjusted HRs were significant for hyperglycemia (1.98, 1.68-2.33,
