Apr 2, 2003 - Activities of Caspofungin, Itraconazole, Posaconazole, Ravuconazole,. Voriconazole, and Amphotericin B against 448 Recent. Clinical Isolates ...
JOURNAL OF CLINICAL MICROBIOLOGY, Aug. 2003, p. 3623–3626 0095-1137/03/$08.00⫹0 DOI: 10.1128/JCM.41.8.3623–3626.2003 Copyright © 2003, American Society for Microbiology. All Rights Reserved.
Vol. 41, No. 8
Activities of Caspofungin, Itraconazole, Posaconazole, Ravuconazole, Voriconazole, and Amphotericin B against 448 Recent Clinical Isolates of Filamentous Fungi D. J. Diekema,1,2* S. A. Messer,2 R. J. Hollis,2 R. N. Jones,3,4 and M. A. Pfaller2,5 Department of Internal Medicine1 and Department of Pathology,2 University of Iowa College of Medicine, and Department of Epidemiology, University of Iowa College of Public Health,5 Iowa City, and Jones Microbiology Institute, North Liberty,3 Iowa, and Tufts University School of Medicine, Boston, Massachusetts4 Received 2 April 2003/Returned for modification 23 April 2003/Accepted 6 May 2003
We examined the in vitro activity of caspofungin, posaconazole, voriconazole, ravuconazole, itraconazole, and amphotericin B against 448 recent clinical mold isolates. The endpoint for reading caspofungin was the minimum effective concentration (MEC). Among the triazoles, posaconazole was most active, inhibiting 95% of isolates at
