Adipocyte Triglyceride Turnover Is Independently ... - Semantic Scholar
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Adipocyte Triglyceride Turnover Is Independently ... - Semantic Scholar
Keith Frayn, PhD; Samuel Bernard, PhD; Kirsty Spalding, PhD; Peter Arner, MD, PhD ... Because limited 14C data were available, triglyceride age was also ...... Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC.
ORIGINAL RESEARCH
Adipocyte Triglyceride Turnover Is Independently Associated With Atherogenic Dyslipidemia Keith Frayn, PhD; Samuel Bernard, PhD; Kirsty Spalding, PhD; Peter Arner, MD, PhD
Background-—Inappropriate storage of fatty acids as triglycerides in adipocytes and their removal from adipocytes through lipolysis and subsequent oxidation may cause the atherogenic dyslipidemia phenotype of elevated apolipoprotein B levels and subsequent hypertriglyceridemia. We tested whether turnover of triglycerides in fat cells was related to dyslipidemia. Methods and Results-—The age of triglycerides (reflecting removal) and triglyceride storage in adipocytes was determined under free living conditions by measuring incorporation of atmospheric 14C into these lipids within the adipocytes in 47 women and 26 men with a large interindividual variability in body mass index. Because limited 14C data were available, triglyceride age was also determined in 97 men and 233 women by using an algorithm based on adipocyte lipolysis, body fat content, waist-to-hip ratio, and insulin sensitivity. This cohort consisted of nonobese subjects since obesity per se is related to all components in the algorithm. Triglyceride turnover (age and storage) was compared with plasma levels of apolipoproteins and lipids. Plasma levels of apolipoprotein B and triglycerides were positively related to triglyceride age in adipocytes, when measured directly using radiocarbon analyses (r=0.45 to 0.47; P
