ONCOLOGY LETTERS 3: 756-760, 2012. 756. Abstract. Adiponectin is a hormone secreted by adipose tissue and has a variety of functions including the ...
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ONCOLOGY LETTERS 3: 756-760, 2012
Adiponectin receptor 2 is negatively associated with lymph node metastasis of colorectal cancer MASAYA HIYOSHI1, NELSON H. TSUNO1,2, KENSUKE OTANI1, KAZUSHIGE KAWAI1, TAKESHI NISHIKAWA1, YASUTAKA SHUNO1, KAZUHITO SASAKI1, KUMIKO HONGO1, MANABU KANEKO1, EIJI SUNAMI1, KOKI TAKAHASHI2, HIROKAZU NAGAWA1 and JOJI KITAYAMA1 Departments of 1Surgical Oncology, and 2Transfusion Medicine, Faculty of Medical Sciences, the University of Tokyo, Tokyo 113-8655, Japan Received December 20, 2011; Accepted February 1, 2012 DOI: 10.3892/ol.2012.583 Abstract. Adiponectin is a hormone secreted by adipose tissue and has a variety of functions including the inhibition of tumor growth. The expression and function of the two major adiponectin receptors, AdipoR1 and AdipoR2, in malignant tissue have not been well characterized. In the present study, we evaluated the mRNA levels of AdipoR1 and AdipoR2 expression in 48 surgically resected colorectal cancer specimens, as well as normal colonic mucosa, by quantitative RT-PCR. The values obtained were standardized by β-actin mRNA, and the correlation between their relative expression levels and the clinicopathological characteristics of the patients was examined. The relative expression levels of AdipoR1 and AdipoR2 were significantly reduced in cancer tissue compared with normal tissue (AdipoR1: 0.97±0.39 vs. 1.37±0.41, P
