Adrenal Insufficiency in Cirrhosis Patients - Jaypee Journals
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Adrenal Insufficiency in Cirrhosis Patients - Jaypee Journals
in the liver. Free cortisol may increase in cirrhosis due to hypoalbuminemia. It may also increase in sepsis and critical illness as the level of CBG is decreased.
EJOHG 10.5005/jp-journals-10018-1237
Hali Rakici
RESEARCH ARTICLE
Adrenal Insufficiency in Cirrhosis Patients: Evaluation of 108 Case Series Hali Rakici Department of Gastroenterology, Recep Tayyip Erdogan Üniversitesi, Riza, Turkey
ABSTRACT Aim: Adrenal insufficiency (AI) in cirrhosis is an issue that has recently gained momentum. It can be seen in both stable and critically ill (sepsis, septic shock, and gastrointestinal system bleeding) cirrhotic patients. Its prevalence exists in a wide range since standardization of diagnostic methods is lacking. We aimed to scrutinize this issue in a 108 case series. Materials and methods: We studied the presence of AI and its stage in patients with cirrhosis and its complications by using cross-sectional study. Standard-dose short synacthen test (SD-SST) was performed in 108 patients that had Child C decompensated cirrhosis without critical illness and it was aimed to determine the prevalence of AI based on basal cortisol, peak cortisol, and delta cortisol (basal total cortisol minus peak cortisol after stimulation) levels. Results: The prevalence of AI in cirrhosis was found to be 25% based on basal cortisol level of
