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[email protected] Current Drug Safety, 2017, 12, 000-000
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RESEARCH ARTICLE
Adverse Drug Reactions Related to Drug Administration in Hospitalized Patients Luca Gallelli1, Antonio Siniscalchi2,*, Caterina Palleria1, Laura Mumoli1, Orietta Staltari1, Aida Squillace1, Francesca Maida1, Emilio Russo1, Santo Gratteri3, Giovambattista De Sarro1,”G&SP” Working Group 1
Department of Health Science, School of Medicine, University of Catanzaro, Clinical Pharmacology and Pharmacovigilance Unit, MaterDomini Hospital, Catanzaro; 2Department of Neurology, Annunziata Hospital Cosenza, Italy; 3 Department of Medical and Surgical Sciences, School of Medicine, University of Catanzaro
Abstract: Introduction: Drug treatment may be related to the development of adverse drug reactions (ADRs). Aim: In this paper, we evaluated the ADRs in patients admitted to Catanzaro Hospital.
A R T I C L E H I S T O R Y
Received: February 27, 2017 Revised: April 18, 2017 Accepted: May 29, 2017 DOI: 10.2174/1574886312666170616090640
Method: After we obtained the approval by local Ethical Committee, we performed a retrospective study on clinical records from March 01, 2013 to April 30, 2015. The association between drug and ADR or between drug and drug-drug-interactions (DDIs) was evaluated using the Naranjo’s probability scale and Drug Interaction Probability Scale (DIPS), respectively. Results: During the study period, we analyzed 2870 clinical records containing a total of 11,138 prescriptions, and we documented the development of 770 ADRs. The time of hospitalization was significantly higher (P
