Allelic diversity at the primate major histocompatibility ... - Springer Link

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Alfredo Corell, Pablo Morales, Pilar Varela, Estela Paz-Artal, J. Manuel Martin-Villa, Jorge Martinez-Laso,. Antonio Arnaiz-Villena. Immunogenetics 36: 33-38, ...
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lmmunogenetics 36: 404-405, 1992

llnO-

genetics

© Springer-Verlag 1992

Erratum Allelic diversity at the primate major histocompatibility complex DRB6 locus Alfredo Corell, Pablo M o r a l e s , Pilar Varela, Estela Paz-Artal, J. Manuel Martin-Villa, Jorge M a r t i n e z - L a s o , Antonio Arnaiz-Villena Immunogenetics 36: 33-38, 1992

The nomenclature in Figures 1 and 2B is erroneous due to a printing error, the correct figures are shown below. Also, the first sentence of the note added in p r o o f should read: "Recently w e have obtained another H L A - D R B 6 allele sequence linked to D R w l 6 individuals: D R B 6 * 0 2 0 2 "; and the first sentence o f the second paragraph should read: "The names D R B 6 * 0 1 0 1 , D R B 6 * 0 2 0 1 , and D R B 6 * 0 2 0 2 . . . " . I,

I )i R B - A m p A p 3

HLA-DRB6

*0101

CCC

4 ACA

5 GCA

6

7

CGT

TTC

*o2oi ~ i ~ ~ ~ ~ ~4 ~ ~J ~ ~ : ...................

....

~v~

~tr-D~6

8 TTG ~ .

9 GAG

i0

ii

CAG

GCT

12 AAG

13

14

15

16

17

18

TGT

GAG

TGT

CAT

ATC

TTC

POpy-DRB6

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

AAG

eGG

GTG

CAG

TAC

CTG

AAC

AGA

TAC

ATC

CAT

AAA

CGG

GAG

GAG

AAC

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

CA

.

~ --- ~. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

o. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

~. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

~~

~

~

~.;~ --- ~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

c. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

A .........

,010~ ~ _ ~

~

~

~3

~

~

c. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

~ .........

---

~.................................

~

C- O. . . . . . . ~. . . . . . . . . . .

C. . . . . . . . .

-~-

39

40

41

42

43

44

45

46

47

48

49

50

51

52

53

54

55

56

57

58

59

60

61

CCC

TTC

GAC

AGC

GAC

GTG

GAG

GAG

TTC

CAG

GCA

GTT

ACG

GAA

CTG

GGG

CGG

CCT

GTC

GCA

GAG

AAC

TGG

• 0201

-G ..........

A ......................................................................

-G ..........

A ......................................................................

-G-

"0106

-G ..............................

-0107

-G ................

"0108

-G ..............................

G

*0203

-G ...............

G

"0102

-G .................................

--T

..........................

A

"0201

-G .................

• 0202

-G ....

-G ............

G ........

G-

62 AAC

*0101

76

77

78

79

80

81

82

83

84

GTG

GAC

ACC

TAC

TGC

AGA

TAC

AGT

TAC

GGG

.O2Ol ~. . . . . HLA-DRBVI

A .....

63

64

65

66

67

68

69

70

71

72

73

74

AGC

CAG

AAG

GGA

ATC

CTG

GAG

GAG

AAT

CGG

GAC

AAG

C

....

C .........

G

.........

C

....

C .........

G

.........

G

.........

--G

--A

...........................................................

G

.........

G

--A

...........................................................

G

.........

--G

--A

....................

G

.........

--A

.............................

G

.........

--A

C

......................................

...................................... A

................

A ...............

.....................................................................

--G

...............................................

C

....

C .........

G

.........

G

--G

...............................................

C

....

C .........

G

.........

r"

8 5 I T 86 GT

TT

~8 7 GAG

i

A ..........

88

89

AGC

TTC

L~ i

.......

BB

.............

A ...........................

"0107

.......

mm

.............

A ..................

• 0108

.......

mm

.............

A .................................

*0203

..................................................

"0102

.......

.............

A .....

90

91

DRB-6125 92

93

94 TGA

ACA

GTG

CAG

CCG

E

E

| .................................................

T A

.....

..............

A-T-

l ...........................

~o~-~,~ .02 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . l II l • o202 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

ks

i

T ........................

• 0106

BI

~i ---

G

~ .............................. GA ..............

~

-.G

C .........................

75

~

~. . . . . . . . . . . . . .

.............

G

C

~

G--G

= ................

A .........

~

o. . . . . . . . . . .

*0101

"0301

~. . . . . . . . . . . . . .

~

~

~_-~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -c~

~

T .......................................... ~. . . . . . . . . . . . . . . . . . . . . . . . .

DRB-AmpB

GOgo-DRB6

.

38 CTG

~ .........

.....................................

J

HLA-DRB6

.

3F7

~

HLA-DRBVI

Gogo-DRB6

22 ATG

.OLO7 ~ ~7

. .%. . .~ . . . . .~ ... .o2o2 ~

Patr-DRB6

20 GGG

~-:~ ................................................................................

Gogo-DRB6 *0203 ~ i ~ ~ @~ ~ ~ . . . . . . . . . . . . . . . . . . . . . . . . . . . .OLO2 ~ i ! ~ ~ ~ ~ ~2~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ~o~-o~, .O2Ol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

HLA-DRB6

19 AAT

. . . . .. . . . .. . . . .. . . . .. . . . .. . . . ... . . ... . . ... . . ... . . ... . . ... . . ... . . ... . . . .. . . . .

.O3Ol~ i ~ ~ ~@~~ i ~

,010~ ~:: ~ ~i~ ~ ~

DRB-600

Im M

gtgaacgcgg

cggggggctg

ggcctgagtc

cctgtgagct

C .......

g .... • .................................

A

-C ......

g .............

A

-C ......

g--t ..........

0-

A

-C ......

g .............

g-

a-g .............

g-

g .............

g-

-GA A

m

G

...... -C ......

ggg

g-

| ................................................ ~. . . . . . . . . . . . . ~. . . . . . , - , , = !

[]

Fig. 1. Comparison of HLA-DRB6, Patr-DRB6, Gogo-DRB6, and Popy-DRB6 exon-2 and intron-2 beginning nucleotide sequences. Uppercase and lowercase letters denote exon and intron nucleotides, respectively. Asterisks represent nonsequenced regions, black squares represent deletions. The insertion is depicted by a thin vertical arrow and shadowed areas correspond to the primers used for amplification in each sequence. Thick black horizontal arrows show length, direction, sequence, and name of used primers. HLA-DRB6*0101 and "0201 are from Corell and co-workers 1991; HLA-DRBVI is from Figueroa and co-workers 1991. EMBL accession numbers: 1) HLA-DRB6*0101, X53357, "0201: X53358; 2) PatrDRB6*0301, X60798, "0106, X60799, "0107: X60800, "0108, X60801; 3) Gogo-DRB6*0203, X60802, "0102, X60803; 4) Popy-DRB6*0201, X60804, *0202: X60805. Registration dates: a) human alleles: August 16, 1990; b) ape alleles: July 9, 1991.

405

A ORB1

DRB2

C) REI 4

DRB3

DRB5

DR86

DQB1

DPBI

B Patr.DRB6 "0301

r---V------

Gogo-DRB6 *0203 HLA-DRB6 *OlOI

m

1

P~D~6

"0108

p~D~6

"0107

G o ~ - D ~ 6 "0102 P o ~ - D ~ 6 *0202 H~-D~

Fig. 2. A Dendrogram depicting the relationship between human DRB consensus sequences for exon-2 comparisons. B Dendrogram depicting the relationship between nine DRB6 alleles from four different primate species.