Alfredo Corell, Pablo Morales, Pilar Varela, Estela Paz-Artal, J. Manuel Martin-Villa, Jorge Martinez-Laso,. Antonio Arnaiz-Villena. Immunogenetics 36: 33-38, ...
]llll
lmmunogenetics 36: 404-405, 1992
llnO-
genetics
© Springer-Verlag 1992
Erratum Allelic diversity at the primate major histocompatibility complex DRB6 locus Alfredo Corell, Pablo M o r a l e s , Pilar Varela, Estela Paz-Artal, J. Manuel Martin-Villa, Jorge M a r t i n e z - L a s o , Antonio Arnaiz-Villena Immunogenetics 36: 33-38, 1992
The nomenclature in Figures 1 and 2B is erroneous due to a printing error, the correct figures are shown below. Also, the first sentence of the note added in p r o o f should read: "Recently w e have obtained another H L A - D R B 6 allele sequence linked to D R w l 6 individuals: D R B 6 * 0 2 0 2 "; and the first sentence o f the second paragraph should read: "The names D R B 6 * 0 1 0 1 , D R B 6 * 0 2 0 1 , and D R B 6 * 0 2 0 2 . . . " . I,
I )i R B - A m p A p 3
HLA-DRB6
*0101
CCC
4 ACA
5 GCA
6
7
CGT
TTC
*o2oi ~ i ~ ~ ~ ~ ~4 ~ ~J ~ ~ : ...................
....
~v~
~tr-D~6
8 TTG ~ .
9 GAG
i0
ii
CAG
GCT
12 AAG
13
14
15
16
17
18
TGT
GAG
TGT
CAT
ATC
TTC
POpy-DRB6
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
AAG
eGG
GTG
CAG
TAC
CTG
AAC
AGA
TAC
ATC
CAT
AAA
CGG
GAG
GAG
AAC
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
CA
.
~ --- ~. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
o. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
~. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
~~
~
~
~.;~ --- ~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
c. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
A .........
,010~ ~ _ ~
~
~
~3
~
~
c. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
~ .........
---
~.................................
~
C- O. . . . . . . ~. . . . . . . . . . .
C. . . . . . . . .
-~-
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
CCC
TTC
GAC
AGC
GAC
GTG
GAG
GAG
TTC
CAG
GCA
GTT
ACG
GAA
CTG
GGG
CGG
CCT
GTC
GCA
GAG
AAC
TGG
• 0201
-G ..........
A ......................................................................
-G ..........
A ......................................................................
-G-
"0106
-G ..............................
-0107
-G ................
"0108
-G ..............................
G
*0203
-G ...............
G
"0102
-G .................................
--T
..........................
A
"0201
-G .................
• 0202
-G ....
-G ............
G ........
G-
62 AAC
*0101
76
77
78
79
80
81
82
83
84
GTG
GAC
ACC
TAC
TGC
AGA
TAC
AGT
TAC
GGG
.O2Ol ~. . . . . HLA-DRBVI
A .....
63
64
65
66
67
68
69
70
71
72
73
74
AGC
CAG
AAG
GGA
ATC
CTG
GAG
GAG
AAT
CGG
GAC
AAG
C
....
C .........
G
.........
C
....
C .........
G
.........
G
.........
--G
--A
...........................................................
G
.........
G
--A
...........................................................
G
.........
--G
--A
....................
G
.........
--A
.............................
G
.........
--A
C
......................................
...................................... A
................
A ...............
.....................................................................
--G
...............................................
C
....
C .........
G
.........
G
--G
...............................................
C
....
C .........
G
.........
r"
8 5 I T 86 GT
TT
~8 7 GAG
i
A ..........
88
89
AGC
TTC
L~ i
.......
BB
.............
A ...........................
"0107
.......
mm
.............
A ..................
• 0108
.......
mm
.............
A .................................
*0203
..................................................
"0102
.......
.............
A .....
90
91
DRB-6125 92
93
94 TGA
ACA
GTG
CAG
CCG
E
E
| .................................................
T A
.....
..............
A-T-
l ...........................
~o~-~,~ .02 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . l II l • o202 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ks
i
T ........................
• 0106
BI
~i ---
G
~ .............................. GA ..............
~
-.G
C .........................
75
~
~. . . . . . . . . . . . . .
.............
G
C
~
G--G
= ................
A .........
~
o. . . . . . . . . . .
*0101
"0301
~. . . . . . . . . . . . . .
~
~
~_-~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . -c~
~
T .......................................... ~. . . . . . . . . . . . . . . . . . . . . . . . .
DRB-AmpB
GOgo-DRB6
.
38 CTG
~ .........
.....................................
J
HLA-DRB6
.
3F7
~
HLA-DRBVI
Gogo-DRB6
22 ATG
.OLO7 ~ ~7
. .%. . .~ . . . . .~ ... .o2o2 ~
Patr-DRB6
20 GGG
~-:~ ................................................................................
Gogo-DRB6 *0203 ~ i ~ ~ @~ ~ ~ . . . . . . . . . . . . . . . . . . . . . . . . . . . .OLO2 ~ i ! ~ ~ ~ ~ ~2~ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ~o~-o~, .O2Ol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
HLA-DRB6
19 AAT
. . . . .. . . . .. . . . .. . . . .. . . . .. . . . ... . . ... . . ... . . ... . . ... . . ... . . ... . . ... . . . .. . . . .
.O3Ol~ i ~ ~ ~@~~ i ~
,010~ ~:: ~ ~i~ ~ ~
DRB-600
Im M
gtgaacgcgg
cggggggctg
ggcctgagtc
cctgtgagct
C .......
g .... • .................................
A
-C ......
g .............
A
-C ......
g--t ..........
0-
A
-C ......
g .............
g-
a-g .............
g-
g .............
g-
-GA A
m
G
...... -C ......
ggg
g-
| ................................................ ~. . . . . . . . . . . . . ~. . . . . . , - , , = !
[]
Fig. 1. Comparison of HLA-DRB6, Patr-DRB6, Gogo-DRB6, and Popy-DRB6 exon-2 and intron-2 beginning nucleotide sequences. Uppercase and lowercase letters denote exon and intron nucleotides, respectively. Asterisks represent nonsequenced regions, black squares represent deletions. The insertion is depicted by a thin vertical arrow and shadowed areas correspond to the primers used for amplification in each sequence. Thick black horizontal arrows show length, direction, sequence, and name of used primers. HLA-DRB6*0101 and "0201 are from Corell and co-workers 1991; HLA-DRBVI is from Figueroa and co-workers 1991. EMBL accession numbers: 1) HLA-DRB6*0101, X53357, "0201: X53358; 2) PatrDRB6*0301, X60798, "0106, X60799, "0107: X60800, "0108, X60801; 3) Gogo-DRB6*0203, X60802, "0102, X60803; 4) Popy-DRB6*0201, X60804, *0202: X60805. Registration dates: a) human alleles: August 16, 1990; b) ape alleles: July 9, 1991.
405
A ORB1
DRB2
C) REI 4
DRB3
DRB5
DR86
DQB1
DPBI
B Patr.DRB6 "0301
r---V------
Gogo-DRB6 *0203 HLA-DRB6 *OlOI
m
1
P~D~6
"0108
p~D~6
"0107
G o ~ - D ~ 6 "0102 P o ~ - D ~ 6 *0202 H~-D~
Fig. 2. A Dendrogram depicting the relationship between human DRB consensus sequences for exon-2 comparisons. B Dendrogram depicting the relationship between nine DRB6 alleles from four different primate species.
