Original Research published: 25 October 2017 doi: 10.3389/fpsyt.2017.00205
Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration Yi Lu1†, Zonglin Shen 2†, Yuqi Cheng 2†, Hui Yang 3, Bo He1, Yue Xie1, Liang Wen1, Zhenguang Zhang1, Xuejin Sun1, Wei Zhao1, Xiufeng Xu2 and Dan Han1* 1 Department of Medical Imaging, The First Affiliated Hospital, Kunming Medical University, Kunming, China, 2 Department of Psychiatry, The First Affiliated Hospital, Kunming Medical University, Kunming, China, 3 Biomedical Engineering Research Center, Kunming Medical University, Kunming, China
Edited by: Amit Anand, Cleveland Clinic Lerner College of Medicine, United States Reviewed by: Taolin Chen, West China Hospital of Sichuan University, China Mirko Manchia, Dalhousie University, Canada *Correspondence: Dan Han
[email protected] †
These authors have contributed equally to this work. Specialty section: This article was submitted to Mood and Anxiety Disorders, a section of the journal Frontiers in Psychiatry Received: 04 July 2017 Accepted: 02 October 2017 Published: 25 October 2017
Citation: Lu Y, Shen Z, Cheng Y, Yang H, He B, Xie Y, Wen L, Zhang Z, Sun X, Zhao W, Xu X and Han D (2017) Alternations of White Matter Structural Networks in First Episode Untreated Major Depressive Disorder with Short Duration. Front. Psychiatry 8:205. doi: 10.3389/fpsyt.2017.00205
Frontiers in Psychiatry | www.frontiersin.org
It is crucial to explore the pathogenesis of major depressive disorder (MDD) at the early stage for the better diagnostic and treatment strategies. It was suggested that MDD might be involving in functional or structural alternations at the brain network level. However, at the onset of MDD, whether the whole brain white matter (WM) alterations at network level are already evident still remains unclear. In the present study, diffusion MRI scanning was adopt to depict the unique WM structural network topology across the entire brain at the early stage of MDD. Twenty-one first episode, short duration (
