Abstract. Background: Gastrointestinal carcinogenesis generally follows the adenoma-adenocarcinoma sequence and tumor metastasis determines the survival ...
ANTICANCER RESEARCH 26: 2353-2360 (2006)
An Immunohistochemical Study of P53 and Ki-67 in Gastrointestinal Adenoma and Adenocarcinoma using Tissue Microarray HUACHUAN ZHENG1,2, KOICHI TSUNEYAMA1,2, CHUNMEI CHENG3, HIROYUKI TAKAHASHI1, ZHENGGUO CUI1,2, YOSHIHIRO MURAI1, KAZUHIRO NOMOTO1 and YASUO TAKANO1 1Department
of Pathology (1), and 221st Century COE Program, Faculty of Medicine, University of Toyama, Sugitani 2630, Toyama, Japan; 3Division of Rheumatology, Allergy and Clinical Immunology, University of California, Suite 6510, Davis, U.S.A.
Abstract. Background: Gastrointestinal carcinogenesis generally follows the adenoma-adenocarcinoma sequence and tumor metastasis determines the survival time of the patients. The expressions of p53 and ki-67 in gastrointestinal adenoma and adenocarcinoma (GIA) were explored and their clinicopathological significance determined. Materials and Methods: The expressions of mutant p53 and ki-67 were examined on tissue microarray containing GIA, adjacent mucosa or adenoma and metastases by immunostaining. Their expressions were compared with the clinicopathological parameters of tumors. Results: The expressions of mutant p53 and ki-67 were gradually increased from gastrointestinal mucosa to adenocarcinoma through adenoma (p
