Amanda N. Sferruzzi-Perri,*,1 Owen R. Vaughan,* Maria Haro,† Wendy N. Cooper,†. Barbara Musial,* Marika Charalambous,* Diogo Pestana,† Shruti Ayyar,*.
The FASEB Journal • Research Communication
An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory Amanda N. Sferruzzi-Perri,*,1 Owen R. Vaughan,* Maria Haro,† Wendy N. Cooper,† Barbara Musial,* Marika Charalambous,* Diogo Pestana,† Shruti Ayyar,* Anne C. Ferguson-Smith,† Graham J. Burton,* Miguel Constancia,*,† and Abigail L. Fowden* *Centre for Trophoblast Research, Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, UK; and †Metabolic Research Laboratories, Department of Obstetrics and Gynaecology and National Institute for Health Research, Cambridge Biomedical Research Centre, Cambridge, UK In developed societies, high-sugar and high-fat (HSHF) diets are now the norm and are increasing the rates of maternal obesity during pregnancy. In pregnant rodents, these diets lead to cardiovascular and metabolic dysfunction in their adult offspring, but the intrauterine mechanisms involved remain unknown. This study shows that, relative to standard chow, HSHF feeding throughout mouse pregnancy increases maternal adiposity (ⴙ30%, P
