and maximum likelihood (ML) - PLOS

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ZP 02156222.1|Shewanella benthica KT99. 100. 100 ...... YP 001556954.1|Shewanella baltica OS195 ...... YP 001760148.1|Shewanella woodyi ATCC 51908.
Figure A1. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposases containing tnp_31 domain Tnp. Bootstrap supports higher than or equal to 60% are shown on the branches. Rma p07 RmaB p13

NJ

Ram18 p20 Ram32 p47 Rrh p08 Rra1 p06

97

Reis1 p39 Rfe pd47 87

RfeI1 p80

Pla smids

Rfe p80 Rra2 p096 Rhe p19 100

Reis1 p60-Reis1 p61 Raf p05 Raf p04 Reis2 p12-Reis2 p13 Reis4_p16008485 Reis4_p160125-26

100

Ram23 p21-Ram23 p22-Ram23 p23 Rpa1286-88 Rsl 1215-16 Raf1394-95 RriSh1413-16 Rpe1531-34

97

Rmo850555-56 Rph1289-91 Rja1278 Rel1276-77 Ram YP 005365797.1 68

Rsi246 1312 94

Rfe0280

97

88

Chromosome s

Rra1420-22

Rhe0561-63 99

RbeRML0626 OtsIk0163 OtsIk1893

100

84

Rhe0964 Reis0990

98

Rpa0885

81

OtsIk2583 OtsIk1610

100

Chromosome s

OtsIk2101

90 99

OtsIk0570 Rhe p55

80

Rra2 p027 Ram23 p45

60

RfeI1 p58 78 67

Rfe pd24 Rfe p57 Reis3 p06

Pla smids

Rau p01 rpr22 CDS696-98 98

79

RprME0877-79

Rpe p28-Rpe p29 Rmo p04-Rmo p05-Rmo p06 Rra1 p09-11 Rra3 p10

67

RbeRML0059

74 99

Rak0514-16 RbeRML0074

Rel0927-30 99

95

Rra0840-42 Rja0912-15 Rfe0709

80

Chromosome s

Rhe1408-09 RbeRML1399

97

RbeRML1656 Rfe1409-10

78

Rhe1747-49

89

Rau1549-51

77

99

98 87

Rak0302-304

Reis0948 Rph0863 Ram YP 005365648.1 Rpa0888 Rpe1124 Rra1099 Reis1024 RbeRML0510

89

Chromosome s

Rmo850167 Reis1026 Reis1764

99

Reis0385 Reis1225 Reis1581 Rma 0898 YP 003518376.1|Pantoea ananatis LMG 20103 100

0.5

ZP 10225398.1|Pantoea agglomerans IG1

Rma p07

69 67

RmaB p13

65

Rrh p08 Rra1 p06

77

Ram18 p20 Ram32 p47 Reis2 p12-Reis2 p13 Ram23 p21-Ram23 p22-Ram23 p23 99

ML

Reis1 p39

Pla smids

Raf p05

68

Raf p04 Reis16008485 Reis160125-26

99

Reis1 p60-Reis1 p61 Rhe p19

95

Rra2 p096 Rfe p80 Rfe pd47 96

RfeI1 p80 Rpe1531-34 RriSh1413-16 Rpa1286-88

81

Rsl 1215-16 Raf1394-95 Rph1289-91 Rja1278 Rel1276-77

90 81

Ram YP 005365797.1 Rmo850555-56 59

Rra1420-22

Chromosome s

Rsi246 1312

83

85

Rfe0280

97

Rhe0561-63 89

RbeRML0626 OtsIk0163 OtsIk1893

99 64

Reis0990 Rhe0964

98

Rpa0885

66

OtsIk2583 OtsIk1610

99

Chromosome s

OtsIk2101

84

OtsIk0570

98

Rfe p57 95

RfeI1 p58 Rfe pd24 Ram23 p45 Rhe p55

96

Rra2 p027 Reis3 p06

Pla smids

Rau p01 59

rpr22 CDS696-98 RprME0877-79

99 93

Rpe p28-Rpe p29 Rmo p04-Rmo p05-Rmo p06 Rra1 p09-11

63

Rra3 p10

71

RbeRML0059

79

85 99

Rak0514-16 RbeRML0074

Rfe0709 Rhe1408-09

88

Rel0927-30

97 93

98

Rja0912-15

Chromosome s

Rra0840-42 RbeRML1399

99

RbeRML1656 Rfe1409-10

78

Rhe1747-49

89

Rau1549-51

98 99 66

Rak0302-304

Reis1225 Reis1581 Reis1026

62

Reis0385 Reis1764 Rma 0898 Rra1099

Chromosome s

Reis1024 RbeRML0510 Rmo850167 99

Rpa0888 Rpe1124 Ram YP 005365648.1 Reis0948

91

Rph0863 YP 003518376.1|Pantoea ananatis LMG 20103 99

0.2

ZP 10225398.1|Pantoea agglomerans IG1

Figure A2. Neighbor-joining (NJ) and maximum likelihood (ML) trees of patatin-like phospholipases Pat. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ Rfe p18

70 70

Rfe pd18 RfeI1 p18

82

Plasmids

Rra2 p029

80

Rau p14-Rau p15

70

Ram32 p28 Rra3 p33

100

Rhe0767 Rak1138 92 97

Rca0450

Chromosomes

Rca4100398 Rfe0453 Reis1970 Rau0727

RbeOSU0603

99

RbeRML1026-27 Ram YP 005365687.1 Raf1218 Rpa1123 Rsi246 1482 Rco 1027 100

Rsim C220002 RslD1115

90 99

Rsl 1062 Rpe0875 Rph1120

94

RriBr0400

94 94

Chromosomes

RriIo1254

99

RriSh1230 Rel1116 97

Rja1143 Rty0750

59

RprME0716

99 100

rpr22 CDS578

Rrh1253 76

RmaB0770

91 Rma 1179

Rra1245 Rmo850402 YP 001958055.1|Candidatus Amoebophilus asiaticus 5a2 100 92

99

ZP 10207867.1|Planococcus antarcticus DSM 14505 ZP 08093183.1|Planococcus donghaensis MPA1U2 NP 966337.1|Wolbachia endosymbiont of Drosophila melanogaster

63

XP 002989501.1|Selaginella moellendorffii NP 195423.1Arabidopsis thaliana

95 99

0.5

XP 003574632.1|Brachypodium distachyon

Rfe p18

52

ML

99

Rfe pd18

70

RfeI1 p18

55

Plasmids

Rra2 p029

65

Rau p14-Rau p15

72

Rra3 p33 Ram32 p28

100

100

Rca0450 Rca4100398 Reis1970

Chromosomes

Rhe0767

54

Rfe0453 Rak1138

64 99

Rau0727 RbeOSU0603

100

RbeRML1026-27 Rty0750

100

RprME0716 100 100

rpr22 CDS578

RmaB0770

74 98

Rma 1179 Rrh1253 Rra1245

99

Rmo850402 Ram YP 005365687.1

77

Rpe0875 Rph1120

52

Chromosomes

RriIo1254 91

RriBr0400 98

RriSh1230 50 99 17

Rpa1123 Rsi246 1482 Raf1218 Rco 1027 Rsim C220002

100

RslD1115

100

Rsl 1062 Rel1116

100

Rja1143

YP 001958055.1|Candidatus Amoebophilus asiaticus 5a2 100 86

100

ZP 10207867.1|Planococcus antarcticus DSM 14505 ZP 08093183.1|Planococcus donghaensis MPA1U2 NP 966337.1|Wolbachia endosymbiont of Drosophila melanogaster

51

XP 002989501.1|Selaginella moellendorffii NP 195423.1Arabidopsis thaliana

98 86

0.2

XP 003574632.1|Brachypodium distachyon

Figure A3. Neighbor-joining (NJ) and maximum likelihood (ML) trees of thymidylate kinase. Bootstrap supports higher than or equal to 60% are shown on the branches.

Ram32 p26 98

NJ

Rra2 p030 Rfe p20 99

Plasmids

Rfe pd20 99

RfeI1 p20 RbeOSU1492

98

99

RbeRML0282 Rty0863

99

RprME0826 100

rpr22 CDS661

100

Rca1161

99

Rca4100990 RriIo1430 66

RriSh1408 RriBr0242 Rco 1173

98

Rpa1283 Rpe1527 RslD1276 64 Rsl 1212

Rph1286 65

89

Chromosomes

Rsi246 1315 Rsim C230164 Raf1391 Rel1273

59

Rja1275 Rma YP 005365794.1 Rra1416

59

Rma 1344 RmaB0607

65

Rrh1411 Rmo850552 Reis2244 70

Rhe0571 Rfe0284 Rak1290 Rau0573 OtsBo1434

100

OtsIk0735

Chromosomes

YP 004679220.1|Candidatus Midichloria mitochondrii IricVA YP 879227.1|Clostridium novyi NT YP 006178705.1|Halobacillus halophilus DSM 2266

93 70

ZP 09004600.1|Paenibacillus lactis 154 YP 145877.1|Geobacillus kaustophilus HTA426

0.2

Ram32 p26 91

Rra2 p030

ML

Rfe pd20 94

Plasmids

Rfe p20 99

RfeI1 p20 97 97

RbeOSU1492 RbeRML0282 Rfe0284 Rak1290 Rau0573

90

66 RslD1276

Rsl 1212 Raf1391 Rco 1173

89

Rsi246 1315 61

Rsim C230164 Rpa1283 Rpe1527 RriBr0242 RriIo1430

60

RriSh1408 91

Rph1286

Chromosomes

Rja1275 Rel1273 Rmo850552 Rma YP 005365794.1 Rra1416 Rma 1344 RmaB0607 59

Rrh1411 62

Reis2244 Rhe0571 Rca1161

99

Rca4100990 Rty0863 96 99

RprME0826 rpr22 CDS661 OtsBo1434

99

OtsIk0735

Chromosomes

YP 004679220.1|Candidatus Midichloria mitochondrii IricVA YP 879227.1|Clostridium novyi NT 98

YP 145877.1|Geobacillus kaustophilus HTA426 YP 006178705.1|Halobacillus halophilus DSM 2266 ZP 09004600.1|Paenibacillus lactis 154

0.2

Figure A4. Neighbor-joining (NJ) and maximum likelihood (ML) trees of heat shock protein Hsps. Bootstrap supports higher than or equal to 60% are shown on the branches. Rfe pd37 100

NJ

RfeI1 p70 Rfe p70 Rmo p14 Ram23 p10 Rra1 p30

68

Pla smids

Rhe p35

100

Rra2 p003 Reis4_p160097

88

Reis4_p160114 Reis1 p48

99

Reis2 p79 100 100

Rpe p22

RbeOSU0608

99

RbeRML1021 Rty0337

99

RprME0315 rpr22 CDS268

100

Rak0473

87

92

Rau1373 Rel0451 Rra0466 Rja0439 94

Rmo851326 Rpe0548 Rma YP 005365114.1 RslD0451 Rsl 426

67 60

Chromosome s

Rrh0568 Rma 0451

91

RmaB1434 Rph0443 76

RriIo0505 71

RriBr1055 66

RriSh0500 Rco 402 60

Raf0491

67

Rpa0439 Rsi246 0441 Rsim C150025

61

Rfe1283 Rhe1567 Rca0381 100

Rca4100337

Reis1 p47 Rpe p23 Rfe pd36 97

RfeI1 p69 Rfe p69 99

75

Rhe p36

Pla smids

Rra1 p31 Rra2 p004 Ram23 p11

65

Reis4_p160096 59

99

Reis4_p160115

Rmo p13 Reis2 p80-Reis2 p81 Rfe1282 61

Chromosome s

ZP 06684430.1|Achromobacter piechaudii ATCC 43553 YP 001580469.1|Burkholderia multivorans ATCC 17616 YP 005027723.1|Dechlorosoma suillum PS

100 66 99

EHY75890.1|Pseudomonas stutzeri ATCC 14405 CCUG 16156 ZP 10761901.1|Pseudomonas pseudoalcaligenes CECT 5344

YP 001250938.1|Legionella pneumophila str. Corby

0.2

Rfe p70 99

Rfe pd37 RfeI1 p70

Ram23 p10

79

Rhe p35 Rra1 p30 99

ML

Rra2 p003

Plasmids

Rmo p14

93

Reis4_p160097 72

Reis4_p160114 Reis1 p48

98

Reis2 p79 99

Rpe p22

99

RbeOSU0608

78

RbeRML1021 Rty0337

98

RprME0315 99

rpr22 CDS268 Rak0473

86

Rau1373 Rma YP 005365114.1 Rel0451 Rja0439 Rra0466 62

Rmo851326 Rpe0548 Rph0443 RriBr1055 74

RriIo0505

Chromosomes

RriSh0500 RmaB1434

64

Rrh0568

59

Rma 0451 RslD0451 Rsl 426

72

67 Raf0491

Rpa0439 67

Rco 402 Rsi246 0441 Rsim C150025 Rfe1283 Rhe1567 Rca0381

99

Rca4100337

Rfe pd36 75

Rfe p69 RfeI1 p69 Ram23 p11 Rmo p13 Reis4_p160115

87

Reis4_p160096

Plasmids

Rra2 p004 Rra1 p31

66 99

Rhe p36

Rpe p23 97

Reis2 p80-81 Reis1 p47 Rfe1282 74 71 99

Chromosomes ZP 10761901.1|Pseudomonas pseudoalcaligenes CECT 5344

YP 001580469.1|Burkholderia multivorans ATCC 17616 ZP 06684430.1|Achromobacter piechaudii ATCC 43553 YP 005027723.1|Dechlorosoma suillum PS

98

71

EHY75890.1|Pseudomonas stutzeri ATCC 14405 CCUG 16156

YP 001250938.1|Legionella pneumophila str. Corby

0.2

Figure A5. Neighbor-joining (NJ) and maximum likelihood (ML) trees of dnaA-like replication initiator protein. Bootstrap supports higher than or equal to 60% are shown on the branches. The short sequences of about 318 aa of R. prowazekii strains were included in the the third NJ tree of dnaA-like domain and its flaking regions.

81

Rma p01

82

RmaB p20

71

Rrh p01

100

Ram18 p11 Rra1 p19

NJ

Reis4 p160108 Ram32 p09-13 Ram23 p29 Reis2 p37 RfeI1 p10 100

Rfe p10

100 97

Rfe pd10

Rau p13

Pla smids

Rhe p01

98

Rra2 p040

100

Rfe p26-28

72 99

RfeI1 p26-29

Rpe p09

79

Rra3 p31 Raf p01

100 81

Rra2 p023 Reis1 p09

97

Rmo p25

80

Reis3 p11

86

RbeOSU0485 Reis2088 100

OtsIk1585 OtsIk0455

100

Rrh1000 68 68 97

87

Raf0947 Rra0765 Rrh0994 Rma 0924

RbeOSU1264 RbeRML0501 Reis0957 90

Rmo850176 Rph0870

0.5

Chromosome s

84 Rma p01 89

RmaB p20 Rrh p01

100

Ram18 p11 Rra1 p19

ML

Ram32 p09-13 Ram23 p29 Rau p13 Rhe p01

100 79

Rra2 p040

95

Rfe p26-28

79

RfeI1 p26-29

100

Plasmids

Reis2 p37 Reis4 p160108 RfeI1 p10 100

100

Rfe p10

88 Rfe pd10

Reis3 p11 67

Rmo p25 Raf p01

100 78 100

Rra2 p023

Reis1 p09

80

Rra3 p31 78

Rpe p09 RbeOSU0485 100

OtsIk1585 OtsIk0455 Reis2088

99

100 96 74

83

Raf0947 Rra0765 Rrh0994

Rma 0924 Rrh1000

100

RbeOSU1264 RbeRML0501

66

Reis0957 100

Rmo850176 Rph0870

0.2

Chromosomes

NJ

Rfe p26-28

100

RfeI1 p26-29 RprME0862 82

rpr22 CDS687

100

RfeI1 p10 62

Rfe p10

100

Rfe pd10

99

Rhe p01 Rra2 p040

99

Raf p01 Rra2 p023

100

Rau p13 Rmo p25 Reis4 p160108

100

Plasmids

Ram23 p29 Reis2 p37 Ram32 p09-13 Ram18 p11 71

Rra1 p19 Rrh p01

100

Rma p01

96 91

RmaB p20

Rpe p09 100

Reis1 p09 Rra3 p31 Reis3 p11 RbeOSU0485 Reis2088 100

OtsIk1585 OtsIk0455

68

99

Raf0947 Rra0765

78

Rrh0994 Rma 0924 Rrh1000

RbeOSU1264 99

RbeRML0501 Reis0957 71

Rmo850176 Rph0870

0.5

Chromosomes

Figure A6. Neighbor-joining (NJ) and maximum likelihood (ML) trees of helix-turn-helix DNA-binding domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

68

NJ

Rra2 p036 Rra2 p044

72 99

Rhe p56 Rhe p05 Ram32 p07

94

Ram32 p17

RmaB p04 100

Rma p17 Ram18 p05 Rrh p17

Plasmids

Raf p12 Reis1 p12 Reis3 p12 Rra2 p055 100 66 100

Rfe p39 RfeI1 p41 Rmo p28

Rmo p29 RfeI1 p05 Rfe p05 100

Rfe pd05 OtsBo2381 100

0.2

OtsIk2720

Chromosomes

ML

Raf p12 Reis1 p12 Reis3 p12 Rra2 p055 Rfe p39

98

RfeI1 p41

91 100

Rmo p28 Rmo p29

Rfe p05 RfeI1 p05 100

Plasmids

Rfe pd05 Rma p17 90 100

Rrh p17 RmaB p04 Ram18 p05 92 Ram32 p07

Ram32 p17 Rhe p05

100

Rhe p56 78

Rra2 p036

78 Rra2 p044

OtsBo2381 99

0.2

OtsIk2720

Chromosomes

Figure A7. Neighbor-joining (NJ) and maximum likelihood (ML) trees of the autotransporter region of cell surface antigen Sca12. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rfe p32-35 sca12

100

RfeI1 p34-37 sca12

92

Raf p11 sca12 93

Rra2 p033-34 sca12

70 100

84

Rra2 p046-47 sca12

Pla smids

Ram23 p34-38 sca2 100

Rra2 p019-20 sca12 Reis3 p16 sca12 Rra3 p26 sca12

100

Rak0152 sca2 Ram YP 005364905.1 sca2 Rco 128 sca2 81

Raf0152 sca2

83

Rra0157 sca2

91

72

Reis0550-546 sca2

94

Rfe0083 sca2 RprME0092-0089 sca6

100

Rty0060 sca6

100

RbeRML1556 sca2 RbeRML0424-426 sca8

Chromosome s

Rfe1364 sca8

100

Rra0331-336 sca8

100

Ram YP 005365012-5013 sca8

71

Raf0337-0346 sca8 Rhe1704-1698 sca8

90

RbeRML0203 sca1 rpr22 CDS014-16 sca1

100

Rfe0029 sca1

100

Reis2256 sca1

89

Ram YP 005364824.1 sca1

98

Raf0027 sca1

99 91

RriSh0034 sca1

Rfe0058-0060 sca10 100

Rhe0097-0094 sca10 Raf1444 sca5

98

Rpe0314 sca5

77

Rra1465 sca5 96

Ram YP 005365823.1 sca5 Rfe0250 sca5

59

rpr22 CDS682 sca5

95

Rhe0517 sca5 100

Reis0060-0059 sca5 RbeRML0221 sca5 100 100

rpr22 CDS442 sca3 Rty0572 sca3

99

Rfe0883 sca3 Rfe0602-0607 sca7

65

Rpe1241-1250 sca13 Rfe1638 sca13

100

RbeRML0179-0180 sca13 89

Rfe1661-1656 sca0

91

Rhe0291 sca0

100

Rpe1221-2123 sca0

100

Raf1674 sca0

99 92 71 66

Reis2337-2336 sca0 Rra1691 sca0 Ram YP 005365984.1 sca0 OtsBo0145 sca0-like

0.5

100 Rra2 p033-34 sca12

Rra2 p046-47 sca12 96

ML

Raf p11 sca12

66

Rra2 p019-20 sca12 Ram23 p34-38 sca2

96

Plasmids

Rfe p32-35 sca12 RfeI1 p34-37 sca12

95

Reis3 p16 sca12 Rra3 p26 sca12

100

Reis0550-546 sca2 75

9890 100

99

Rra0157 sca2 Ram YP 005364905.1 sca2 Raf0152 sca2 Rco 128 sca2 Rak0152 sca2

96

Rfe0083 sca2 RprME0092-0089 sca6

95 99

Rty0060 sca6

RbeRML1556 sca2 Raf0337-0346 sca8 60 90

Rra0331-336 sca8 Ram YP 005365012-5013 sca8 Rfe1364 sca8

89

Rhe1704-1698 sca8 59

RbeRML0424-426 sca8 Rfe0058-0060 sca10 100

Rhe0097-0094 sca10

69

RbeRML0203 sca1 rpr22 CDS014-16 sca1

98

Rfe0029 sca1

95

Reis2256 sca1 Ram YP 005364824.1 sca1 91 98

0,5

Raf0027 sca1 RriSh0034 sca1

Chromosomes

Figure A8. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraD domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

Rau p28 Rra2 p104 Reis1 p02 Ram32 p39

NJ

Rfe p53

Plasmids

93 RfeI1 p53

Rra3 p11 Reis3 p04 100

Reis2 p96 Reis2 p76-77 OtsIk1754 94 70

OtsIk0941 OtsIk2702

100

OtsIk0167 OtsIk2662

Ram YP 005365437.1 Rma 0920 Rca0661

64

Rpa0877 Rhe0987

98

Chromosomes

Rhe0999 98

YP 004680183.1|Ca. Midichloria sp.

Reis1762 Reis0994 Reis0950 RbeOSU1256 91 RbeRML0508

Rmo850169 YP 002424237.1|Methylobacterium chloromethanicum CM4

0.2

Rra2 p104 Reis1 p02 Ram32 p39

ML

Reis3 p04 Rfe p53

59

Plasmids

93 RfeI1 p53

Reis2 p76-77

98

Rra3 p11 Rau p28 Reis2 p96 YP 002424237.1|Methylobacterium chloromethanicum CM4 OtsIk1754 95 100

OtsIk0941 OtsIk2702 OtsIk0167 OtsIk2662

Ram YP 005365437.1 Rma 0920 Reis1762 Reis0994 RbeRML0508 RbeOSU1256 91 Reis0950

Rmo850169 Rhe0987 Rca0661

96

Rpa0877 Rhe0999 YP 004680183.1|Ca. Midichloria sp.

0.2

Chromosomes

Figure A9. Neighbor-joining (NJ) and maximum likelihood (ML) trees of leucine rich-repeat containing protein. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

RmaB p18 100

Rma p03

Plasmids

Ram18 p01

63

Rra1 p17

71 100

Rrh p03

RbeRML0529 97 100

Reis0929 RbeOSU1235 Rmo850156

Chromosomes

Rpe0198

99

Reis1759 YP 004029052.1|Burkholderia rhizoxinica HKI 454 YP 001957289.1|Candidatus Amoebophilus asiaticus 5a2

100

YP 003572975.1|Candidatus Amoebophilus asiaticus 5a2

100

YP 001958190.1|Candidatus Amoebophilus asiaticus 5a2

84 91

0.2

YP 001958456.1|Candidatus Amoebophilus asiaticus 5a2

Rma p03

ML

RmaB p18

Plasmids

Ram18 p01

98

Rra1 p17

81

Rrh p03 Reis1759 Reis0929 83 Rmo850156

95

RbeOSU1235 98

Chromosomes

RbeRML0529 Rpe0198 YP 004029052.1|Burkholderia rhizoxinica HKI 454 YP 001957289.1|Candidatus Amoebophilus asiaticus 5a2

98

YP 003572975.1|Candidatus Amoebophilus asiaticus 5a2

96

YP 001958190.1|Candidatus Amoebophilus asiaticus 5a2

66 88

0.2

YP 001958456.1|Candidatus Amoebophilus asiaticus 5a2

Figure A10. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing PDDEXK_2 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

77 100

Reis1 p51

Plasmids

Reis1 p05 Rpe p24

98

NJ

YP 006706043.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705885.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

100 77 100

YP 006705381.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella OtsIk2661 OtsIk2703 OtsIk0790

74 OtsIk1407

OtsIk0469

100 64

OtsIk1599 OtsIk0177 OtsIk1254

74

Chromosomes

OtsIk0505 OtsIk0639 OtsIk2205 OtsIk2348 OtsIk2208 OtsIk2588 OtsIk2058 OtsIk2424 OtsIk2337

62 gi|190571716|ref|YP 001976074.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

ZP 03335115.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB 99

YP 001975092.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel ZP 03335568.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB

100

YP 001975046.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel NP 966291.1|Wolbachia endosymbiont of Drosophila melanogaster

100 ZP 09542894.1|Wolbachia pipientis wAlbB

60

ZP 08970974.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis NP 966098.1|Wolbachia endosymbiont of Drosophila melanogaster

97 76

NP 966393.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 01314961.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24 ZP 08970163.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 03335576.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB 100

87 60

ZP 03335651.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB ZP 09542015.1|Wolbachia pipientis wAlbB

YP 001975242.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel ZP 09542444.1|Wolbachia pipientis wAlbB

100

ZP 03788031.1|Wolbachia endosymbiont of Muscidifurax uniraptor ZP 03787978.1|Wolbachia endosymbiont of Muscidifurax uniraptor

74 98

0.05

ZP 00372264.1|Wolbachia endosymbiont of Drosophila simulans

ML

Reis1 p51

83 99

Reis1 p05

Plasmids

Rpe p24

99

YP 006706043.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705885.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

99 97

YP 006705381.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

OtsIk2703 99

OtsIk0790 67 OtsIk1407

OtsIk2337 OtsIk0469 OtsIk1599 99

OtsIk0177 OtsIk2205 OtsIk2348

Chromosomes

OtsIk2058 OtsIk2208 OtsIk2424 OtsIk2588 OtsIk0505 OtsIk0639 OtsIk1254 OtsIk2661 ZP 08970974.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis 88

NP 966393.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 00372264.1|Wolbachia endosymbiont of Drosophila simulans 99

0.1

YP 001975242.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

Figure A11. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing PDDEXK_2 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

Plasmids

Rmo p36 69

YP 006705668.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 98

NJ

100

YP 006706025.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705791.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705750.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

99

YP 006706103.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

60

YP 006706046.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

92

YP 006706080.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

90

NW 002145881.1|Hydra magnipapillata scf1101284924767 RbeRML0991-92 RbeRML0232-34

100

RbeRML0634-35

97

Rrh1526 Ram YP 005365885.1 94 Raf1536-38 99

Rco 1293-95 Rsi246 1188-89 88

Chromosomes

62 Rpa1409-10

Rpe0761-63 80 RriBr0127-28 86 RriSh1535-36 98

Rsl 1326-27 82 75

Rja1394-95 Rel1390 Rmo850666-67 XP 003743626.1|Metaseiulus occidentalis ZP 10773891.1|Clostridium arbusti SL206

100

ZP 09203746.1|Clostridium sp. DL-VIII 100 YP 002018775.1|Pelodictyon phaeoclathratiforme BU-1

100

YP 002018780.1|Pelodictyon phaeoclathratiforme BU-1 YP 004918070.1|Methylomicrobium alcaliphilum 20Z

100

ZP 09862952.1|Methylomicrobium album BG8 99

0.2

ZP 09862951.1|Methylomicrobium album BG8

Plasmids

Rmo p36 68

YP 006705668.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

ML

YP 006706025.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

99 100

YP 006705791.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705750.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

95

YP 006706103.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

64

YP 006706046.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

91

YP 006706080.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

91

NW 002145881.1|Hydra magnipapillata scf1101284924767 RbeRML0991-92 RbeRML0232-34

100

RbeRML0634-35

99

Rrh1526 Ram YP 005365885.1 95 Raf1536-38 99

Rco 1293-95 Rsi246 1188-89 93

Chromosomes

Rpa1409-10 Rpe0761-63 79

RriBr0127-28

89 RriSh1535-36 99

Rsl 1326-27 81 77

Rja1394-95 Rel1390 Rmo850666-67 XP 003743626.1|Metaseiulus occidentalis ZP 10773891.1|Clostridium arbusti SL206

100

ZP 09203746.1|Clostridium sp. DL-VIII 100 YP 002018775.1|Pelodictyon phaeoclathratiforme BU-1

100

YP 002018780.1|Pelodictyon phaeoclathratiforme BU-1 YP 004918070.1|Methylomicrobium alcaliphilum 20Z

100

ZP 09862952.1|Methylomicrobium album BG8 99

0.2

ZP 09862951.1|Methylomicrobium album BG8

Figure

A12.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

transposase/integrase containing HTH_38 and rve domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

Ram32 p10-11

94

Rra3 p05-07 98

Plasmids

Rfe1249 50 Rfe0064-65 Rfe0367-68

85 Rfe0432-33

Chromosomes

Rfe0490-91

NJ

Rfe0557-58 YP 001250688.1|Legionella pneumophila str. Corby 99 YP 006509323.1|Legionella pneumophila subsp. pneumophila 71 YP 195666.1|Azoarcus sp. EbN1 100

YP 195687.1|Azoarcus sp. EbN1 YP 158868.1|Aromatoleum aromaticum EbN1

99

YP 157416.1|Aromatoleum aromaticum EbN1 YP 003165383.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 NP 518368.1|Ralstonia solanacearum GMI1000 100 NP 520454.1|Ralstonia solanacearum GMI1000

YP 583418.1|Cupriavidus metallidurans CH34 99 ZP 03570626.1|Burkholderia multivorans CGD2M 90 ZP 03577850.1|Burkholderia multivorans CGD2 99 YP 006719283.1|Geobacter metallireducens GS-15

YP 006720085.1|Geobacter metallireducens GS-15

84

YP 389398.1|Desulfovibrio alaskensis G20 100 YP 389895.1|Desulfovibrio alaskensis G20

ref|NZ CH991884.1| Escherichia albertii 98

YP 003297121.1|Edwardsiella tarda EIB202 ZP 02229746.1|Yersinia pestis biovar Antiqua str. E1979001 ZP 06018142.1|Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884 YP 002039122.1|Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188 YP 003294863.1|Edwardsiella tarda EIB202

YP 002800294.1|Azotobacter vinelandii DJ 99 YP 002800770.1|Azotobacter vinelandii DJ

YP 003165384.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1

0.5

Rra3 p05-07 Ram32 p10-11

93

Plasmids Plasmids

Rfe0064-65 62

ML

Rfe0490-91 Rfe0557-58

63

95 Rfe1249 50

Chromsomes

Rfe0367-68 Rfe0432-33 YP 001250688.1|Legionella pneumophila str. Corby 100 YP 006509323.1|Legionella pneumophila subsp. pneumophila 100 NP 518368.1|Ralstonia solanacearum GMI1000

NP 520454.1|Ralstonia solanacearum GMI1000 YP 003165383.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 68 YP 157416.1|Aromatoleum aromaticum EbN1 99

YP 158868.1|Aromatoleum aromaticum EbN1 100 YP 195666.1|Azoarcus sp. EbN1

YP 195687.1|Azoarcus sp. EbN1 YP 583418.1|Cupriavidus metallidurans CH34 99

ZP 03570626.1|Burkholderia multivorans CGD2M ZP 03577850.1|Burkholderia multivorans CGD2

100 YP 006719283.1|Geobacter metallireducens GS-15

YP 006720085.1|Geobacter metallireducens GS-15 YP 389398.1|Desulfovibrio alaskensis G20 98 YP 389895.1|Desulfovibrio alaskensis G20 69 YP 002039122.1|Salmonella enterica subsp. enterica serovar Kentucky str. CVM29188

ZP 02229746.1|Yersinia pestis biovar Antiqua str. E1979001 97 68

YP 003294863.1|Edwardsiella tarda EIB202 ZP 06018142.1|Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884

YP 002800294.1|Azotobacter vinelandii DJ 77 YP 002800770.1|Azotobacter vinelandii DJ

YP 003165384.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1

0.5

Figure A13. Neighbor-joining (NJ) and maximum likelihood (ML) trees of DNA polymerase III, subunit epsilon. Bootstrap supports higher than or equal to 60% are shown on the branches.

Rfe p48 Ram23 p05-06

NJ

RfeI1 p49 99

Plasmids

RfeI1 p71

100 100

Rfe p71

77 Rfe pd38

100

Reis1788 REIS 1588

Chromosomes

NW 002145881.1|Hydra magnipapillata scf 1101284924767 YP 001925744.1|Methylobacterium populi BJ001

69

YP 001417936.1|Xanthobacter autotrophicus Py2

100

YP 003226437.1|Zymomonas mobilis subsp. mobilis NCIMB 11163 99

ZP 09906368.1|Sphingobium yanoikuyae XLDN2-5

91

ZP 10340154.1|Sphingomonas echinoides ATCC 14820 ZP 07025669.1|Afipia sp. 1NLS2 ZP 06895816.1|Roseomonas cervicalis ATCC 49957 YP 001676609.1|Caulobacter sp. K31 YP 004868097.1|Gluconacetobacter xylinus NBRC 3288 100

ZP 08898803.1|Gluconacetobacter oboediens 174Bp2 ZP 00053177.1|Magnetospirillum magnetotacticum MS-1

71

YP 006381959.1|Tistrella mobilis KA081020-065 YP 004089567.1|Asticcacaulis excentricus CB 48 YP 002550429.1|Agrobacterium vitis S4

100

EHH04105.1|Agrobacterium tumefaciens CCNWGS0286

96

ZP 10732756.1|Rhizobium sp. CF122

59 95

YP 001313979.1|Sinorhizobium medicae WSM419 YP 003060004.1|Hirschia baltica ATCC 49814

0.1

Rfe p48 RfeI1 p49

ML

RfeI1 p71

99 99

Plasmsids

Rfe p71

69 Rfe pd38

96

Ram23 p05-06

99

Reis1788 REIS 1588

Chromosomes

NW 002145881.1|Hydra magnipapillata scf 1101284924767 YP 003060004.1|Hirschia baltica ATCC 49814 100 YP 003226437.1|Zymomonas mobilis subsp. mobilis NCIMB 11163

ZP 09906368.1|Sphingobium yanoikuyae XLDN2-5 100

YP 001417936.1|Xanthobacter autotrophicus Py2 YP 001925744.1|Methylobacterium populi BJ001

79

ZP 10340154.1|Sphingomonas echinoides ATCC 14820 ZP 07025669.1|Afipia sp. 1NLS2 YP 001676609.1|Caulobacter sp. K31

65

ZP 06895816.1|Roseomonas cervicalis ATCC 49957 YP 004868097.1|Gluconacetobacter xylinus NBRC 3288 100

71

ZP 08898803.1|Gluconacetobacter oboediens 174Bp2 ZP 00053177.1|Magnetospirillum magnetotacticum MS-1 YP 006381959.1|Tistrella mobilis KA081020-065

65

YP 002550429.1|Agrobacterium vitis S4 YP 004089567.1|Asticcacaulis excentricus CB 48

100

EHH04105.1|Agrobacterium tumefaciens CCNWGS0286 ZP 10732756.1|Rhizobium sp. CF122

61 79

0,2

YP 001313979.1|Sinorhizobium medicae WSM419

Figure A14. Neighbor-joining (NJ) and maximum likelihood (ML) trees of major facilitator superfamily MFS-type transporter. Bootstrap supports higher than or equal to 60% are shown on the branches. Reis4 p160120-74

99 98

Reis4 p160091-69

100

Rmo p19

Pla smids

Rra3 p18

85

NJ

Reis1671-70

Chromosome s

Rca0660

100

Ram YP 005365644.1

100

Rmo p23 Ram YP 005365660.1

100

Pla smids Chromosome s

Rfe0564 Rra0749-50 Rfe0494 100

Rau0648-50

Rfe1124 99

RbeRML0820-21 Rca0544

100 100

Rca4100474 Rhe1555-56 RbeOSU0721-20

100

RbeRML0692-91 Rfe1689-90 100

Rau0295 YP 001958245.1|Ca. Amoebophilus asiaticus 5a2 Rfe0500-502

100

Rra1315-18 RbeOSU0699-700

100

Rfe1221-220 RbeOSU0702-03

98

RbeRML0672

100 85

RbeRML0676

RbeOSU1154

100

RbeRML0983 Rfe0228

100

Rja1337-39

64

Rel1336-38

100

Rra1486

78 70

Rma 1406-06-1733 Rrh1463-65 RslD1339-41 Rsi246 1245-48

100 91

Rsl 1273-93

Rfe0562 100 100

RbeOSU0685-86 RbeRML0657-58

88

RbeOSU0487 100

RbeRML1260

Rra0888

99 99 99

RprME0363 rpr22 CDS307 Rty0389

75

Rak0560 Rau1299 Rfe0646 Rca0995

100 100

Rca4100849 Reis1173 Rhe1478 RmaB1348

99

Rma 0532 Rrh0642 Rra0563

62

Ram YP 005365178.1 Rel0533

78

Rja0520 Rmo851390 Rpe1057 RriBr0976 RriIo0593 RriSh0587 Rph0515 Raf0578 Rpa0519

67 Rsi246 54

Rsim C140072 Rco 478 RslD0524 89

Rsl 500

ZP 08776972.1|Candidatus Odyssella thessalonicensis L13 ZP 09798446.1|Gordonia terrae NBRC 100016 100

YP 001154916.1|Polynucleobacter necessarius subsp. asymbioticus QLW -P1DMW A-1 ZP 08776911.1|Candidatus Odyssella thessalonicensis L13

0.2

Reis4 p160120-74

95 96

Reis4 p160091-69

99

ML

Rmo p19

62

Plasmids

Rra3 p18 Reis1671-70 Ram YP 005365644.1

99

Chromosomes

Rfe0564 Rmo p23

64

Ram YP 005365660.1

99

Plasmids Chromosomes

RbeRML0692-91 Rfe1689-90 99

Rau0295 Rca0544

99

Rhe1555-56 RbeRML0672 Rfe0494 99

Rau0648-50

RbeRML1260

99

Rfe0562 Rra0749-50 YP 001958245.1|Ca. Amoebophilus asiaticus 5a2 Rfe0500-502 99

Rra1315-18

RbeRML0983 Rfe0228

99 99

99 98

Rsl 1273-93 Rra1486 Rak0560 Rau1299 Rfe0646 Rca0995

99 97

rpr22 CDS307 Rty0389

60

Reis1173 Rhe1478

97

Rrh0642 Rma 0532 Rra0563 Ram YP 005365178.1

86

RriSh0587 Rpe1057

60

Rsi246 54 Rco 478 Rpa0519 RslD0524

83 Rsl 500

ZP 08776972.1|Candidatus Odyssella thessalonicensis L13 ZP 09798446.1|Gordonia terrae NBRC 100016

0.5

Figure A15. Neighbor-joining (NJ) and maximum likelihood (ML) trees of SMR-type multidrug efflux transporter. Bootstrap supports higher than or equal to 60% are shown on the branches.

91

NJ

Rpe p38

Plasmids

Rhe p26 100

100 Rra2 p1061

RbeOSU1594 100 RbeRML0183 100

Chromosomes

ZP 05087673.1|Pseudovibrio sp. JE062 YP 005079532.1|Pseudovibrio sp. FO-BEG1

66

ZP 02062959.1|Rickettsiella grylli 100

YP 005451523.1|Bradyrhizobium sp. ZP 09648048.1|Bradyrhizobium sp. WSM471

70

ZP 09291012.1|Mesorhizobium alhagi CCNWXJ12-2 97

YP 004139817.1|Mesorhizobium ciceri biovar biserrulae WSM1271 YP 318926.1|Nitrobacter winogradskyi Nb-255 ZP 08520584.1|Aeromonas caviae Ae398 YP 545743.1|Methylobacillus flagellatus KT

60

61

ZP 01915318.1|Limnobacter sp. MED105 AFH50331.1|Ignavibacterium album JCM 16511 63

YP 004585985.1|Halopiger xanaduensis YP 004808478.1|halophilic archaeon DL31

99 73

YP 003405579.1|Haloterrigena turkmenica DSM 5511 ZP 08559824.1|Halorhabdus tiamatea ZP 08095765.1|Planococcus donghaensis MPA1U2 YP 005044615.1|Burkholderia sp. YI23

80

ZP 09891071.1|Listeriaceae bacterium TTU M1-001 93

0.1

YP 003596209.1|Bacillus megaterium DSM 319

100

ML

Rhe p26

Plasmids

Rra2 p1061

97

Rpe p38 79

89

RbeOSU1594 100 RbeRML0183 100

Chromosomes

ZP 05087673.1|Pseudovibrio sp. JE062 YP 005079532.1|Pseudovibrio sp. FO-BEG1

82

ZP 02062959.1|Rickettsiella grylli 100 YP 005451523.1|Bradyrhizobium sp.

ZP 09648048.1|Bradyrhizobium sp. WSM471 ZP 09291012.1|Mesorhizobium alhagi CCNWXJ12-2 88

YP 004139817.1|Mesorhizobium ciceri biovar biserrulae WSM1271 YP 318926.1|Nitrobacter winogradskyi Nb-255 ZP 08520584.1|Aeromonas caviae Ae398 gi|383803251|gb|AFH50331.1|Ignavibacterium album JCM 16511 YP 003405579.1|Haloterrigena turkmenica DSM 5511 ZP 08559824.1|Halorhabdus tiamatea

99

YP 004585985.1|Halopiger xanaduensis

64 79

YP 004808478.1|halophilic archaeon DL31

YP 545743.1|Methylobacillus flagellatus KT ZP 01915318.1|Limnobacter sp. MED105 ZP 08095765.1|Planococcus donghaensis MPA1U2 YP 005044615.1|Burkholderia sp. YI23 ZP 09891071.1|Listeriaceae bacterium TTU M1-001 87

0.1

YP 003596209.1|Bacillus megaterium DSM 319

Figure A16. Neighbor-joining (NJ) and maximum likelihood (ML) trees of type I restrictionmodification system methyltransferase subunit. Bootstrap supports higher than or equal to 60% are shown on the branches.

Rpe p10-11

100

NJ

Reis1 p07-08

100

RbeOSU0130-131 98

100

RbeRML0066-67

Plasmids Chromosomes

RbeOSU0576-79 77

100

RbeRML1049-50 ZP 08170293.1|Anaerococcus hydrogenalis ACS-025-V-Sch4 EGJ45067.1|Streptococcus sanguinis SK1059

100 100

EGJ36816.1|Streptococcus sanguinis SK49

YP 002574319.1|Caldicellulosiruptor bescii DSM 6725 99

AEZ43437.1|Escherichia coli O55:H7 str. RM12579 100 EHV31834.1|Escherichia coli DEC5C

ZP 02156222.1|Shewanella benthica KT99

0.2

ML

91

Rpe p10-11 Reis1 p07-08

91

RbeOSU0130-131 100

RbeRML0066-67

Plasmids Chromosomes

RbeOSU0576-79 99

RbeRML1049-50 ZP 08170293.1|Anaerococcus hydrogenalis ACS-025-V-Sch4 100

gi|332367332|gb|EGJ45067.1|Streptococcus sanguinis SK1059 100 gi|332358995|gb|EGJ36816.1|Streptococcus sanguinis SK49

YP 002574319.1|Caldicellulosiruptor bescii DSM 6725 84

gi|374361730|gb|AEZ43437.1|Escherichia coli O55:H7 str. RM12579 97 gi|377968440|gb|EHV31834.1|Escherichia coli DEC5C

ZP 02156222.1|Shewanella benthica KT99

0.5

Figure A17. Neighbor-joining (NJ) and maximum likelihood (ML) trees of peptidase family M50. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ 82 Reis1 p37 100 100

Rra2 p092-93

Plasmids

Rhe p17 Rhe1024-25 100 100

Chromosomes

YP 003181684.1|Eggerthella lenta DSM 2243 gi|295106959|emb|CBL04502.1|Gordonibacter

YP 003151070.1|Cryptobacterium curtum DSM 15641 ZP 03567474.1|Atopobium rimae ATCC 49626

98

ZP 07665185.1|Atopobium vaginae DSM 15829

69

ZP 09045592.1|Olsenella sp. oral taxon 809 str. F0356 92

YP 003800902.1|Olsenella uli DSM 7084 100 ZP 08114231.1|Desulfotomaculum nigrificans DSM 574 100

99

YP 004497790.1|Desulfotomaculum carboxydivorans CO-1-SRB YP 001112491.1|Desulfotomaculum reducens MI-1 YP 001211787.1|Pelotomaculum thermopropionicum SI YP 001320342.1|Alkaliphilus metalliredigens QYMF YP 004882059.1|Oscillibacter valericigenes Sjm18-20 YP 002990710.1|Desulfovibrio salexigens DSM 2638

68

YP 003828256.1|Acetohalobium arabaticum DSM 5501 YP 004041885.1|Paludibacter 100

79

YP 002892679.1|Tolumonas auensis DSM 9187 YP 005845344.1|Ignavibacterium album JCM 16511 YP 004752330.1|Collimonas fungivorans Ter331

100

0.1

YP 004618132.1|Ramlibacter tataouinensis TTB310

Rhe p17

ML

65

Plasmids

Rra2 p092-93

92

Reis1 p37 Rhe1024-25 100 99

Chromosomes

YP 003181684.1|Eggerthella lenta DSM 2243 gi|295106959|emb|CBL04502.1|Gordonibacter

YP 003151070.1|Cryptobacterium curtum DSM 15641 ZP 03567474.1|Atopobium rimae ATCC 49626

73

89

ZP 07665185.1|Atopobium vaginae DSM 15829 80

ZP 09045592.1|Olsenella sp. oral taxon 809 str. F0356 75

YP 003800902.1|Olsenella uli DSM 7084 100 ZP 08114231.1|Desulfotomaculum nigrificans DSM 574 90

YP 004497790.1|Desulfotomaculum carboxydivorans CO-1-SRB

92

YP 001112491.1|Desulfotomaculum reducens MI-1 YP 001211787.1|Pelotomaculum thermopropionicum SI YP 002990710.1|Desulfovibrio salexigens DSM 2638 YP 003828256.1|Acetohalobium arabaticum DSM 5501 YP 001320342.1|Alkaliphilus metalliredigens QYMF YP 004882059.1|Oscillibacter valericigenes Sjm18-20 YP 004041885.1|Paludibacter 100

72

YP 002892679.1|Tolumonas auensis DSM 9187

YP 005845344.1|Ignavibacterium album JCM 16511 YP 004752330.1|Collimonas fungivorans Ter331 100

0.2

YP 004618132.1|Ramlibacter tataouinensis TTB310

Figure A18. Neighbor-joining (NJ) and maximum likelihood (ML) trees of integral membrane protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

100 Reis1 p49

Reis2 p78

NJ

77

100

0.1

Plasmids

Rca0179 Rca4100164 Rty0169 96 RprME0166 99 rpr22 CDS141 100 RbeOSU0356 RbeRML1386 Rak0253 Rau1591 Rfe1449 Rhe1798 Rmo851134 Rel0240 Rja0235 Ram YP 005364958.1 RmaB0252 Chromosomes 62 Rrh0345 87 Rma 0239 65 Rra0255 Rsi246 0668 Rco 215 Rsim C270205 Raf0253 RriIo0266 RriBr1273 Rph0226 RriSh0263 Rpa0233 Rpe0305 RslD0234 93 Rsl 224 OtsBo1292 Chromosomes OtsIk0378 100 YP 004357650.1|Candidatus Pelagibacter sp. IMCC9063 100

100

Reis1 p49 Reis2 p78

ML

Plasmids

RbeOSU0356

100

RbeRML1386

76

Rak0253 Rca0179

100

Rca4100164 RprME0166

100

rpr22 CDS141 98

Rty0169 Rhe1798 Rel0240 Rja0235 Ram YP 005364958.1 RmaB0252 59

Rrh0345 86

Rma 0239 94

RslD0234

Chromosomes

Rsl 224 Rpa0233 Rsi246 0668

59

Rsim C270205 Rco 215 Rpe0305 RriSh0263 RriIo0266 Raf0253 Rph0226 RriBr1273 Rra0255 Rmo851134 Rfe1449 Rau1591 OtsBo1292 100

OtsIk0378

Chromosomes YP 004357650.1|Candidatus Pelagibacter sp. IMCC9063

0.1

Figure A19. Neighbor-joining (NJ) and maximum likelihood (ML) trees of DNA adenine methylase domain protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rhe p02

100 98

Plasmids

Rra2 p039 Rfe0150 100

Chromosomes

YP 323171.1|Anabaena variabilis ATCC 29413 NP 484105.1|Nostoc sp. PCC 7120

62

YP 001864396.1|Nostoc punctiforme PCC 73102

84 66

ZP 01628832.1|Nodularia spumigena CCY9414 YP 003723187.1|Nostoc azollae 0708

99

YP 002484516.1|Cyanothece sp. PCC 7425 ZP 03273824.1|Arthrospira maxima CS-328 100

ZP 06384017.1|Arthrospira platensis str. Paraca

YP 394752.1|Lactobacillus sakei subsp. sakei 23K ZP 07822906.1|Peptoniphilus harei ACS-146-V-Sch2b 91

gi|355367220|gb|EHG14933.1|Streptococcus intermedius F0395

100

YP 001035650.1|Streptococcus sanguinis ZP 10258417.1|Weissella confusa LBAE C39-2

90

ZP 08482220.1|Leuconostoc inhae KCTC 3774

100 100

0.1

ZP 08480084.1|Leuconostoc gelidum KCTC 3527

99 Rhe p02

ML 94

Plasmids

Rra2 p039 Rfe0150

Chromosomes

100 YP 323171.1|Anabaena variabilis ATCC 29413

NP 484105.1|Nostoc sp. PCC 7120 YP 001864396.1|Nostoc punctiforme PCC 73102 ZP 01628832.1|Nodularia spumigena CCY9414 YP 003723187.1|Nostoc azollae 0708 98

YP 002484516.1|Cyanothece sp. PCC 7425 ZP 03273824.1|Arthrospira maxima CS-328 99

ZP 06384017.1|Arthrospira platensis str. Paraca

YP 394752.1|Lactobacillus sakei subsp. sakei 23K ZP 07822906.1|Peptoniphilus harei ACS-146-V-Sch2b 80 100 62

gi|355367220|gb|EHG14933.1|Streptococcus intermedius F0395 YP 001035650.1|Streptococcus sanguinis ZP 10258417.1|Weissella confusa LBAE C39-2

73 99

ZP 08482220.1|Leuconostoc inhae KCTC 3774 100 ZP 08480084.1|Leuconostoc gelidum KCTC 3527

0.1

Figure A20. Neighbor-joining (NJ) and maximum likelihood (ML) trees of tryptophan-rich sensory protein, TspO_MBR superfamily protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

81 Rhe p29

NJ

Plasmids

Rra2 p113

67

Chromosomes

OtsIK YP 001937235 85

JH413822.1| Legionella drancourtii LLAP12 YP 003455469.1|Legionella longbeachae NSW150 84

YP 094265.1|Legionella pneumophila 93

YP 125632.1|Legionella pneumophila str. Lens

67

YP 122612.1|Legionella pneumophila str. Paris XP 001632774.1|Nematostella vectensis 100

XP 002052849.1|Drosophila virilis XP 002003644.1|Drosophila mojavensis

99

NP 001006032.1|Danio rerio 100 ADO28402.1|Ictalurus furcatus

NP 001187665.1|Ictalurus punctatus 99

ACO07725.1|Oncorhynchus mykiss 89 NP 001139827.1|Salmo salar 64

ACM08875.1|Salmo salar 78

99

NP 001118098.1|Oncorhynchus mykiss ACO07475.1|Oncorhynchus mykiss ACO13508.1|Esox lucius

78

XP 003454606.1|Oreochromis niloticus AEK25825.1|Micropterus salmoides

93

ACQ58300.1|Anoplopoma fimbria ACQ58508.1|Anoplopoma fimbria

100 ACQ57915.1|Anoplopoma fimbria

ACQ58389.1|Anoplopoma fimbria YP 004679920-19|Ca. Midichloria mitochondrii IricVA

0.5

84

Rhe p29

Plasmids

Rra2 p113 OtsIK YP 001937235 69

Chromosomes

JH413822.1| Legionella drancourtii LLAP12 ACQ58300.1|Anoplopoma fimbria

ML

ACQ58508.1|Anoplopoma fimbria

98

ACQ58389.1|Anoplopoma fimbria ACQ57915.1|Anoplopoma fimbria XP 003454606.1|Oreochromis niloticus AEK25825.1|Micropterus salmoides ACO13508.1|Esox lucius 61 NP 001139827.1|Salmo salar 94 73

ACM08875.1|Salmo salar ACO07725.1|Oncorhynchus mykiss NP 001118098.1|Oncorhynchus mykiss

85

ACO07475.1|Oncorhynchus mykiss ADO28402.1|Ictalurus furcatus 90

NP 001187665.1|Ictalurus punctatus

NP 001006032.1|Danio rerio

88

XP 001632774.1|Nematostella vectensis XP 002052849.1|Drosophila virilis 96

XP 002003644.1|Drosophila mojavensis

YP 003455469.1|Legionella longbeachae NSW150 YP 094265.1|Legionella pneumophila 69

YP 125632.1|Legionella pneumophila str. Lens YP 122612.1|Legionella pneumophila str. Paris YP 004679920-19|Ca. Midichloria mitochondrii IricVA

0.5

Figure A21. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Ram32 p36

99

Rhe p27

Plasmids

99 Rra2 p107 99 RbeOSU1510

60

RbeRML0251 Rel1244 Rja1245 Rra1389

99

Rfe0301 71

Rhe0593 Rak1268

67 88

Rau0596

63 Rsi246 1338

Rsim C230190 RriSh1382

Chromosomes

RriIo1405 Raf1364 RmaB0634 Rmo850524 Rpa1257 Rph1257 Rrh1388 RriBr0267 RslD1249 Rma 1320 Rpe1498 ZP 08778823.1|Candidatus Odyssella thessalonicensis L13 YP 009303.1|Desulfovibrio vulgaris str.

0.2

Ram32 p36

99

Rhe p27

ML

Plasmids

98 Rra2 p107 98 RbeOSU1510

61

RbeRML0251 Rel1244 Rja1245 Rra1389

99

Rhe0593 Rak1268 66

69 84

Rau0596 Rfe0301

63 Rsi246 1338

Rsim C230190 RriSh1382

Chromosomes

RriIo1405 Raf1364 RmaB0634 Rmo850524 Rpa1257 Rph1257 Rrh1388 RriBr0267 RslD1249 Rma 1320 Rpe1498 ZP 08778823.1|Candidatus Odyssella thessalonicensis L13 YP 009303.1|Desulfovibrio vulgaris str.

0.2

Figure A22. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase/IS protein containing AAA domain. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

Ram32 p12 Rra3 p08

100

Pla smids Pla smids

Rfe0063 Rfe0367

95

Rfe0433 87

Rfe0490

100

Chromosome s

Rfe0558 Rfe01250 YP 003709121.1|Waddlia chondrophila WSU 86-1044 100

YP 003710230.1|Waddlia chondrophila WSU 86-1044

72 YP 122176.1|Legionella pneumophila str. Paris 69 100

YP 123885.1|Legionella pneumophila str. Paris YP 006509322.1|Legionella pneumophila subsp. pneumophila YP 001250687.1|Legionella pneumophila str. Corby

100

ZP 10140424.1|Fluoribacter dumoffii YP 001116878.1|Burkholderia vietnamiensis G4 100

ZP 06483097.1|Xanthomonas campestris pv. vasculorum NCPPB 702 NZ GG699235.1|Xanthomonas campestris pv. vasculorum NCPPB702

98

YP 583417.1|Cupriavidus metallidurans CH34 ZP 03588282.1|Burkholderia multivorans CGD1

100 75

ZP 03570625.1|Burkholderia multivorans CGD2M ZP 03573877.1|Burkholderia multivorans CGD2M

93

100

YP 002798163.1|Azotobacter vinelandii DJ YP 002800293.1|Azotobacter vinelandii DJ

YP 002286843.1|Klebsiella pneumoniae

99 100

YP 002286833.1|Klebsiella pneumoniae gi|105989969|gb|ABF81677.1|Klebsiella pneumoniae 77 100

YP 157215.1|Aromatoleum aromaticum EbN1 YP 157415.1|Aromatoleum aromaticum EbN1 YP 195688.1|Azoarcus sp. EbN1

100

YP 003165384.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 100

87

YP 003165807.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 ZP 03271181.1|Burkholderia sp. H160 100

NP 518369.1|Ralstonia solanacearum GMI1000 NP 520455.1|Ralstonia solanacearum GMI1000 ZP 10037612.1|Burkholderia sp. Ch1-1

100

ZP 10030663.1|Burkholderia sp. Ch1-1 99

YP 001893853.1|Burkholderia phytofirmans PsJN 98

YP 001863619.1|Burkholderia phymatum STM815

77 100

YP 006836041.1|Burkholderia phenoliruptrix BR3459a NP 951109.1|Geobacter sulfurreducens PCA YP 006719282.1|Geobacter metallireducens GS-15

97

YP 006720084.1|Geobacter metallireducens GS-15 YP 003294096.1|Edwardsiella tarda EIB202 ZP 03035856.1|Escherichia coli F11 EGB89070.1|Escherichia coli MS 117-3 YP 001711910.1|Escherichia coli

100

YP 006115709.1|Escherichia coli ETEC H10407 NP 754399.1|Escherichia coli CFT073 NP 395139.1|Yersinia pestis CO92 93

NP 053140.1|Escherichia coli B171 ZP 02223939.1|Yersinia pestis biovar Orientalis str. F1991016 YP 005504479.1|Yersinia pestis D106004 YP 005521307.1|Yersinia pestis A1122 ZP 02333471.1|Yersinia pestis FV-1 YP 006116735.1|Escherichia coli ETEC H10407 ZP 02239908.1|Yersinia pestis biovar Antiqua str. B42003004

0.05

Ram32 p12

99

ML

Rra3 p08

Plasmids

Rfe0063

100

Rfe01250 Rfe0367 97 Rfe0433

87

Chromosomes

Rfe0490 Rfe0558 YP 003709121.1|Waddlia chondrophila WSU 86-1044 100 YP 003710230.1|Waddlia chondrophila WSU 86-1044 100 NP 518369.1|Ralstonia solanacearum GMI1000

NP 520455.1|Ralstonia solanacearum GMI1000

100

ZP 10030663.1|Burkholderia sp. Ch1-1

66 90 86

ZP 10037612.1|Burkholderia sp. Ch1-1

ZP 03271181.1|Burkholderia sp. H160 YP 157215.1|Aromatoleum aromaticum EbN1 100

YP 003165807.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1 ZP 10140424.1|Fluoribacter dumoffii YP 001250687.1|Legionella pneumophila str. Corby

100 100 99 97

YP 006509322.1|Legionella pneumophila subsp. pneumophila

YP 002286833.1|Klebsiella pneumoniae YP 002798163.1|Azotobacter vinelandii DJ ZP 03573877.1|Burkholderia multivorans CGD2M 100

YP 006719282.1|Geobacter metallireducens GS-15 NP 951109.1|Geobacter sulfurreducens PCA

YP 005521307.1|Yersinia pestis A1122 ZP 02333471.1|Yersinia pestis FV-1 100 YP 006115709.1|Escherichia coli ETEC H10407

NP 754399.1|Escherichia coli CFT073

0.1

Figure A23. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein Of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rau p19

100

Ram32 p30-32

93

Plasmids

RfeI1 p93 100

Rfe p92

74 Rfe pd59 100 RprME0518 100 77

rpr22 CDS429 Rty0550 RbeOSU0226-27

93

Chromosomes

100 RbeRML1511

Reis0802-03 XP 003289429.1|Dictyostelium purpureum

0.1

ML

100

Rau p19 Ram32 p30-32

86

Plasmids

Rfe pd59 Rfe p92 100

RfeI1 p93 100 RprME0518 100

rpr22 CDS429 Rty0550 RbeOSU0226-27

83

100

Chromosomes

RbeRML1511 Reis0802-03 XP 003289429.1|Dictyostelium purpureum

0.2

Figure A24. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein Of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100

Rfe p38 RfeI1 p40

Plasmids

Ram23 p41 Rty0342 RprME0319

100 82

0.1

rpr22 CDS272

Chromosomes

ML 100

Rfe p38 RfeI1 p40

Plasmids

Ram23 p41 Rty0342 RprME0319 100

rpr22 CDS272

0.1

Chromosomes

Figure A25. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein Of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rfe p37

100

RfeI1 p39 100

RprME0320 rpr22 CDS273

100

Plasmids

Chromosomes

Rty0343

Rfe0569 RbeOSU0694

100 100

0.2

RbeRML0667

Chromosomes

ML 100

Rfe p37 RfeI1 p39 100

RprME0320 rpr22 CDS273

99

Plasmids

Chromosomes

Rty0343

Rfe0569 RbeOSU0694

96 100

0.2

RbeRML0667

Chromosomes

Figure A26. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein Of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rau p17-18 Ram32 p29 Ram23 p15 84

Rfe p15

Plasmids

67

Rfe pd15 99

RfeI1 p15 Rau0103 Rak0174 99

Rhe0083

81

Rca0043 99

Rca4100040

Reis0402

79

Rfe0177 Rel0080

89

Rja0081 Rsi246 0838 Rsim C020031 Rco 70

76

Raf0082 68

Rpa0081 RslD0082

64

72 Rsl 75

Rpe0561 Rph0077 RriBr1421 96

RriIo0098 96

RriSh0094 Rra0087 Ram YP 005364839.1 Rmo850984 Rma 0086 RmaB0031 65

Rrh0188

0.1

Chromosomes

Rau p17-18

ML

Ram23 p15 Ram32 p29 Rfe p15

71

Plasmids

Rfe pd15 100

RfeI1 p15 Rau0103 Reis0402 Rfe0177 Rhe0083

83

Rca0043

100 100

Rca4100040

Rsi246 0838 Rsim C020031 79

Rco 70 Raf0082

59

Rpa0081 RslD0082 61 Rsl 75

Rpe0561 Rph0077 RriBr1421 96

RriIo0098 96

RriSh0094 60

Rel0080

91 Rja0081

Rra0087 Rmo850984 Ram YP 005364839.1 RmaB0031 Rrh0188 Rma 0086 Rak0174

0.1

Chromosomes

Figure A27. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

Reis1 p16 99

Pla smids

Reis1722 Reis2067

NJ

Reis0925 Reis1006

86

Reis1785

99

Rma 0879 Rpe0196 RbeOSU1237 RbeRML0527 Reis0931

99

Rmo850158 OtsBo0893 OtsBo2622 OtsBo1606 OtsBo1694 OtsBo1762 OtsBo1824 OtsBo1390 99

OtsBo1537 OtsBo1245 OtsBo1318 OtsBo0980 OtsBo1181 OtsBo0674 OtsBo0720 89

OtsBo0088 OtsBo0551 OtsBo0047 OtsBo1882 OtsBo2021 OtsBo2116 OtsBo2326 OtsBo2396 OtsBo2578 OtsBo2614 OtsBo2733 OtsBo2783 OtsBo2863 OtsIk0278

68

OtsIk0449 OtsIk0087 OtsIk1725 OtsIk2259 OtsIk2470 OtsIk0313 OtsIk2565 OtsIk2677

64

OtsIk2399 OtsIk2125 OtsIk1797

64

OtsIk0594 OtsIk1425 OtsIk2334 OtsIk0056 OtsIk1058 94

OtsIk1331

0.05

Chromosome s

Reis1 p16

ML

Plasmids

Reis0931 99 Rmo850158

RbeRML0527 RbeOSU1237

99

67 Reis1006

Reis1785 Rma 0879

34 35

Rpe0196

93 OtsBo0047

OtsBo0088 100 63

0.1

OtsIk0056 OtsIk0313

Chromosomes

Figure A28. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rpe p36 100

Plasmids

RbeOSU0908 RbeRML1129

Reis1297 99

Rty0671

100

RprME0630 91

100 rpr22 CDS520 100

Rca0576 Rca4100504

99

Rhe0928 Rfe1086 92 82 86

Rau0883

92

Rrh1106

Rak0955 Rmo850272 RmaB0908

99

Chromosomes

Rma 1025 97 99

Rra0879 Rel0956 Rja0946 Rpe0162 Rph0972

80 95 99 93 72 75 89

RriBr0526 RriIo1092 RriSh1087 Rsi246 1652 Rsim C260004 Rpa0982 Raf1049 Rco 889

74 RslD0964 95 Rsl 917

YP 004680201.1|Ca. Midichloria mitochondrii IricVA 0.2

Rpe p36

ML

Plasmids

100 RbeOSU0908

RbeRML1129 Rca0576

100

Rca4100504 Rty0671 89

100 100

RprME0630 rpr22 CDS520

Rhe0928 Rfe1086 75

Rak0955

75 99

Rau0883 Rrh1106 RmaB0908

65 Rma 1025

Raf1049 75 Rpa0982 91

Chromosomes

Rsi246 1652

95 Rsim C260004 75

Rco 889

RslD0964 8993 Rsl 917 71

Rph0972 RriBr0526

99

RriIo1092 97 84

RriSh1087 Rpe0162 Rel0956

97 Rja0946

Rra0879 Rmo850272 Reis1297 YP 004680201.1|Ca. Midichloria mitochondrii IricVA

0.2

Figure A29. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100

RmaB p16 Rma p05

Plasmids

Rrh p06 Reis2171 Rau0004 Rfe YP 246114.1 RmaB YP 005301561.1 Rma NC 009900.1 Rrh YP 005390004.1 92

0.1

Rmo85 YP 005391871.1

Chromosomes

ML

Rrh p06 100

RmaB p16

Plasmids

Rma p05 Reis2171 Rau0004 Rfe YP 246114.1 Rmo85 YP 005391871.1 RmaB YP 005301561.1 98

Rma NC 009900.1 59

Rrh YP 005390004.1

0.1

Chromosomes

Figure A30. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

Plasmids

Reis1 p18 100 72

Reis1720 Reis2069 Reis0968

75

Reis1008 Rma 0881 100

Rpe0194 70

Reis0923 Reis1783 RbeOSU1239 RbeRML0525

98

Reis0933 Rmo850160 OtsIk2123 OtsIk2679

83

100

OtsIk2567 OtsIk2401

62

OtsIk0311 OtsIk1728 OtsIk2261

62

OtsIk0452 OtsIk0137 OtsIk0694 OtsIk0999

Chromosomes

OtsIk1631

100 77

OtsBo2616 OtsBo2861 OtsBo1880 OtsBo2024 OtsBo2118 OtsBo2324

94

OtsBo1692 OtsBo1760 OtsBo1535 OtsBo1608 OtsBo1316 OtsBo1388

99

OtsBo1179 OtsBo1243 OtsBo0090 OtsBo0718 OtsBo0049 OtsBo2398 OtsBo2580 OtsBo2735 OtsBo2785 ZP 08778975.1|Candidatus Odysella thessalonicensis L13

0.2

Reis1 p18

ML

Plasmids

Reis1008 Rma 0881 Reis0968 Reis1720

62

100 Reis2069

Rpe0194 Reis0923 Reis1783

Chromosomes

Reis0933 Rmo850160 97 RbeRML0525

RbeOSU1239 99 OtsIk0311

OtsIk2679 100

OtsBo0049 99 OtsBo0718

ZP 08778975.1|Candidatus Odysella thessalonicensis L13

0.2

Figure A31. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

Rra3 p34

Plasmids

RbeRML0422

100

RbeOSU1338 Rak0247 99 100

Rca0172 Rca4100157

Reis0516 Rau1598 97

Rfe1462 Rra0248 Rmo851128 Ram YP 005364952.1 100

98 Rsl 218

RslD0227 Raf0245 Rco 208 Rpa0227 Rsim C270211 98 85

Rsi246 0674 Rpe0931 Rph0220

67 94

RriBr1279

100 84

RriSh0255

93 RriIo0258

Rja0229 100

Rel0234 Rrh0338

99 60

0.2

RmaB0244 Rma 0232

Chromosomes

ML Rra3 p34

Plasmids

RbeRML0422 Reis0516 Rak0247 Rau1598

97

Rfe1462 Rca0172 Rmo851128 Rra0248 Ram YP 005364952.1

100

Raf0245 Rpa0227 Rsi246 0674 Rsl 218 97

Rco 208 Rpe0931

93

Rph0220

73 100

RriSh0255 Rja0229

100

Rel0234 Rrh0338

97

0.2

Rma 0232

Chromosomes

Figure A32. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

Rph1078 Rco 1586 Rpe0835 Rsi246 1526 Rpa1086 Raf1177 Rsim C160050 RriSh1186 Rsl 1025 62 RslD1075

RriIo1209 RriBr0442

Chromosomes

Rrh1205 Rma 1136 RmaB0809 Rja1066 Rel1075 Rhe0812 Rmo850363

77

Rfe1218 Rra1202 Rau0765 Ram23 p28

0.1

Plasmids

ML Ram23 p28

Plasmids

Rfe1218 Rau0765 Rco 1586 Rsi246 1526 Raf1177 Rsim C160050 Rph1078 Rpa1086 Rpe0835 RriSh1186 Rsl 1025 64 RslD1075

RriIo1209 60 RriBr0442

Rrh1205 Rma 1136 RmaB0809 Rja1066 Rel1075 Rhe0812 Rra1202 Rmo850363

0.1

Chromosomes

Figure A33. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ Reis1 p21

Plasmids

100 Reis1719

Reis2070 Reis0969

80

Reis0922 87

Reis1782 100

Rma 0882 59

Rpe0193 81

Chromosomes

Reis1009 RbeRML0524

63

Reis0934 83 RbeOSU1240

Rmo850161 OtsBo0889 OtsBo0692 100

OtsIk2568 65

OtsBo2860 OtsIk2473

0.05

Chromosomes

ML Plasmids

Reis1 p21 99 Reis1719

Reis2070 Reis0969

66

Rma 0882 79

Rpe0193 Reis0922

97 60

Reis1782

Chromosomes

Reis0934 69 Rmo850161

RbeOSU1240 65

RbeRML0524 Reis1009 OtsIk2568 OtsBo0692 100

OtsBo0889 OtsBo2860

73 OtsIk2473

0.1

Chromosomes

Figure A34. Neighbor-joining (NJ) and maximum likelihood (ML) trees of guanosine polyphosphate pyrophosphohydrolase/synthetase SpoT22. Bootstrap supports higher than or equal to 60% are shown on the branches.

70 92

NJ

75 100

Rma p04 RmaB p18 Rrh p03

Plasmids

Ram18 p01 Rra1 p17

OtsBo2174 100

OtsIk0424

Chromosomes

100 OtsBo1290

OtsIk0376 YP 001640654.1|Methylobacterium extorquens PA1

100 100 79

ZP 08688334.1|Fusobacterium mortiferum ATCC 9817 ZP 08695526.1|Fusobacterium varium ATCC 27725

91

ZP 09547991.1|Caldithrix abyssi DSM 13497 YP 001709486.1|Clavibacter michiganensis subsp. sepedonicus

0.2

ML 76 70 58 100 100

Rma p04 RmaB p18 Rrh p03

Plasmids

Ram18 p01 Rra1 p17 OtsBo2174

100

OtsIk0424

Chromosomes

100 OtsBo1290

OtsIk0376 YP 001640654.1|Methylobacterium extorquens PA1 YP 001709486.1|Clavibacter michiganensis subsp. sepedonicus

88

ZP 09547991.1|Caldithrix abyssi DSM 13497

85

ZP 08688334.1|Fusobacterium mortiferum ATCC 9817

49 100

0.2

ZP 08695526.1|Fusobacterium varium ATCC 27725

Figure A35. Neighbor-joining (NJ) and maximum likelihood (ML) trees of cell surface antigen Sca4. Bootstrap supports higher than or equal to 60% are shown on the branches.

Reis3 p21

NJ

100

Plasmids

RbeOSU1107 RbeRML0937

99

Rty0626 RprME0584-85

80

100 rpr22 CDS484

Rhe1149 Rca0736 84

100 91

Rca4100619

Rfe0925 Rak0860

93

Rau1012

76 RmaB1072 100

Rma 0817 Rrh0932 Ram YP 005365388 Rmo850100

Chromosomes

Rra0982 76 Raf0881 80 Rpa0816 84

Rsi246 0037

10063 Rco 751

RslD0818 100 100 Rsl 776

Rpe0064 Rph0815 96

RriBr0683 100 98 RriIo0922 99

RriSh0916 Rel0818 99 Rja0801

OtsIk YP 001937526 100 OtsBo YP 001248543

0.5

Chromosomes

ML

Reis3 p21

Plasmids

94 RbeRML0937

RbeOSU1107 Rca0736 Rty0626

70

RprME0584-85 74 rpr22 CDS484

Rhe1149 Rfe0925

88

Rak0860 89

67

Rau1012

Ram YP 005365388 69 Raf0881 74 Rpa0816 81

Chromosomes

Rsi246 0037 Rco 751

88 Rsl 776 82

Rpe0064

81 98 Rph0815 98 RriIo0922

Rel0818 98 Rja0801

Rrh0932 94 Rma 0817

Rmo850100 Rra0982 OtsIk YP 001937526

0.5

Chromosomes

Figure A36. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function.

NJ Reis3 p25 Rra2 p057 Reis ZP 04698404

0.05

Plasmids Chromosomes

ML

Reis3 p25 Rra2 p057 Reis ZP 04698404

0.05

Plasmids Chromosomes

Figure A37. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of transposase DDE-Tnp_1 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

. NJ

Rau p05-06 69

Reis2 p09 81

Plasmids

Reis2 p18-19

68 Reis2 p51-52

Rfe p01-03 100

Rfe pd01-03

Plasmids

RfeI1 p01-03 Rfe1243

86

Rfe0479 84

Chromosomes

Rfe1236 ZP 08779019.1|Ca.Odyssella thessalonicensis L13

0.2

Rau p05-06 82

ML

Reis2 p09 98

Reis2 p18-19

Plasmids

72 Reis2 p51-52

Rfe p01-03 100

Rfe pd01-03

Plasmids

RfeI1 p01-03 Rfe0479

75

Rfe1236 94

Chromosomes

Rfe1243 ZP 08779019.1|Ca.Odyssella thessalonicensis L13

0.2

Figure A38. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraW_N domain. Bootstrap supports higher than or equal to 60% are shown on the branches. Reis3 p32

100

Rra2 p069-70 90

Ram32 p05

79

Pla smids

Reis1 p24

NJ

RbeRML0520

66 68 92 84

Rmo850165 RbeOSU1244 Reis0938

82

Reis1778 Rma 0887 99

Reis0917 Reis1013

79

Reis0973

Chromosome s

Ram YP 005365614.1 OtsIk2572

100

OtsIk0191 100 94 73

OtsIk0144 OtsIk0992

93 79

OtsIk1803 OtsIk2408

YP 096099.1|Legionella pneumophila str. Phi 1 100

ZP 06193675.1|Serratia odorifera 4Rx13 ZP 16217403.1|Serratia plymuthica A30

62

YP 004119613.1|Pantoea sp. At-9b

100 100

100

YP 004118936.1|Pantoea sp. At-9b YP 006271902.1|Rahnella aquatilis HX2 YP 001165571.1|Enterobacter sp. 638

73

ZP 10410191.1|Citrobacter sp. A1

100

YP 003602656.1|Enterobacter cloacae subsp. cloacae ATCC 13047

89 89

gYP 004821608.1|Enterobacter asburiae LF7a YP 001110316.1|Burkholderia vietnamiensis G4

100 99

YP 145641.1|Ralstonia metallidurans CH34

86

YP 001023358.1|Methylibium petroleiphilum PM1 YP 195400.1|Azoarcus sp. EbN1 100

ZP 01451151.1|Mariprofundus ferrooxydans PV-1 ZP 01451151.1|Mariprofundus ferrooxydans PV-1(2) YP 003846739.1|Gallionella capsiferriformans ES-2 100

YP 285530.1|Dechloromonas aromatica RCB YP 285857.1|Dechloromonas aromatica RCB

85 100

YP 004388676.1|Alicycliphilus denitrificans K601

71

YP 004487071.1|Delftia sp. Cs1-4 YP 985800.1|Acidovorax sp. JS42

100

ZP 04764449.1|Acidovorax delafieldii 2AN

85 98

YP 004389207.1|Alicycliphilus denitrificans K601

YP 003853356.1|Parvularcula bermudensis HTCC2503 99

YP 457752.1|Erythrobacter litoralis HTCC2594 ZP 01039318.1|Erythrobacter sp. NAP1 ZP 06861581.1|Citromicrobium bathyomarinum JL354

100

ZP 08701861.1|Citromicrobium sp. JLT1363 YP 457063.1|Erythrobacter litoralis HTCC2594

100

YP 459850.1|Erythrobacter litoralis HTCC2594 100

ZP 01863183.1|Erythrobacter sp. SD-21

99 100

ZP 09192854.1|Novosphingobium pentaromativorans US6-1 YP 004534222.1|Novosphingobium sp. PP1Y ZP 01304680.1|Sphingomonas sp. SKA58 gZP 08207461.1|Novosphingobium nitrogenifigens DSM 19370

59

NP 049159.1|Novosphingobium aromaticivorans

79 100

YP 718072.1|Sphingomonas sp. KA1

65

ZP 09195460.1|Novosphingobium pentaromativorans US6-1 ZP 10341905.1|Sphingomonas echinoides ATCC 14820

75

ZP 10871957.1|Sphingomonas sp. LH128 ZP 08390061.1|Sphingomonas sp. S17

96

ZP 09139087.1|Sphingomonas sp. KC8

74 100

ZP 10340135.1|Sphingomonas echinoides ATCC 14820 YP 008431.1|Candidatus Protochlamydia amoebophila UW E25 ZP 08778792.1|Ca. Odyssella thessaloniensis L13

67

gi|344925259|ref|ZP 08778720.1|Ca.Odyssella thessaloniensis L13 100

0.1

ZP 08778980.1|Ca. Odyssella thessaloniensis L13

Reis3 p32

99

ML

Ram32 p05 81

Rra2 p069-70

84

Plasmids

Reis1 p24 Ram YP 005365614.1 Reis0973 RbeRML0520 Rmo850165 89

97 83

RbeOSU1244

Chromosomes

Reis0938 Reis0917 Rma 0887 OtsIk0191 OtsIk0144 100

OtsIk0992 YP 096099.1|Legionella pneumophila str. Phi 1 ZP 06193675.1|Serratia odorifera 4Rx13

70

YP 003602656.1|Enterobacter cloacae subsp. cloacae ATCC 13047

100

YP 004118936.1|Pantoea sp. At-9b 100

YP 006271902.1|Rahnella aquatilis HX2 YP 008431.1|Candidatus Protochlamydia amoebophila UWE25 ZP 08778792.1|Ca. Odyssella thessaloniensis L13

62 81

ZP 08778980.1|Ca. Odyssella thessaloniensis L13 YP 457063.1|Erythrobacter litoralis HTCC2594 ZP 06861581.1|Citromicrobium bathyomarinum JL354 ZP 01039318.1|Erythrobacter sp. NAP1

100

ZP 08701861.1|Citromicrobium sp. JLT1363 79

ZP 09192854.1|Novosphingobium pentaromativorans US6-1 ZP 10340135.1|Sphingomonas echinoides ATCC 14820 YP 003853356.1|Parvularcula bermudensis HTCC2503 ZP 01451151.1|Mariprofundus ferrooxydans PV-1 100 91

YP 001110316.1|Burkholderia vietnamiensis G4 YP 145641.1|Ralstonia metallidurans CH34

94

YP 001023358.1|Methylibium petroleiphilum PM1 YP 195400.1|Azoarcus sp. EbN1 YP 003846739.1|Gallionella capsiferriformans ES-2 YP 285530.1|Dechloromonas aromatica RCB YP 004487071.1|Delftia sp. Cs1-4

100

YP 004388676.1|Alicycliphilus denitrificans K601

100 68 95

0.2

YP 985800.1|Acidovorax sp. JS42 ZP 04764449.1|Acidovorax delafieldii 2AN

Figure A39. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraG domain. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

Reis1 p31-33 100

Rfe p62-63 100

Rfe pd29-30

Plasmids

RfeI1 p63-65 100 OtsIk1613-16

99

OtsIk2104-07

98

OtsIk2580 OtsIk0573-76 88 91

OtsIk1223-26

Reis0904-05 Rma 0895 RbeRML0513 98 100 Reis0945

Chromosomes

RbeOSU1251 98 61

Rph0860 Reis1770 Rhe0970-71

67 100 Rhe0957-58

Reis1021 100 Ram YP 005365651

ZP 08778727.1|Ca. Odyssella thessaloniensis L13 99

ZP 08778986.1|Ca. Odyssella thessaloniensis L13 ZP 08829147.1|endosymbiont of Riftia pachyptila (vent Ph05) YP 008439.1|Candidatus Protochlamydia amoebophila UWE25 ZP 08778799.1|Ca. Odyssella thessaloniensis L13

ZP 01451140.1|Mariprofundus ferrooxydans PV-1 96 YP 093985.1|Yersinia pestis 97

YP 001154739.1|Yersinia pestis Pestoides F ZP 10409440.1|Citrobacter sp. A1

YP 001542682.1|Fluoribacter dumoffii Tex-KL ZP 10139259.1|Fluoribacter dumoffii Tex-KL

94

YP 003455309.1|Legionella longbeachae NSW150

81 76

YP 122322.1|Legionella pneumophila str. Lens

Reis3 p39 Rra2 p082-83

99 71

0.5

Rra3 p25

Reis1 p31-33 100

Rfe pd29-30

ML

100

Rfe p62-63

Pla smids

RfeI1 p63-65 OtsIk2580

100 84

OtsIk0573-76 OtsIk1223-26

60

OtsIk1613-16

100

OtsIk2104-07

Reis0904-05 Rma 0895 RbeOSU1251 78

Reis0945

76

99

Chromosome s

RbeRML0513 Rph0860 Reis1770 Rhe0970-71

100

Rhe0957-58

Reis1021 Ram YP 005365651 ZP 08778727.1|Ca. Odyssella thessaloniensis L13 100

ZP 08778986.1|Ca. Odyssella thessaloniensis L13

YP 008439.1|Candidatus Protochlamydia amoebophila UWE25 ZP 01451140.1|Mariprofundus ferrooxydans PV-1 ZP 08778799.1|Ca. Odyssella thessaloniensis L13 ZP 08829147.1|endosymbiont of Riftia pachyptila (vent Ph05) 94 97

YP 093985.1|Yersinia pestis YP 001154739.1|Yersinia pestis Pestoides F ZP 10409440.1|Citrobacter sp. A1 YP 001542682.1|Fluoribacter dumoffii Tex-KL

82

ZP 10139259.1|Fluoribacter dumoffii Tex-KL

99

YP 003455309.1|Legionella longbeachae NSW150

86 81

YP 122322.1|Legionella pneumophila str. Lens Reis3 p39 Rra2 p082-83

100 73

0.5

Rra3 p25

Pla smids

Figure A40. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraH domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 14559835.1|Klebsiella pneumoniae 73

YP 006973910.1|Klebsiella pneumoniae

97 YP 003560490.1|Klebsiella pneumoniae

YP 001338639.1|Klebsiella pneumoniae

NJ

61

YP 001338762.1|Klebsiella pneumoniae YP 004249923.1|Klebsiella pneumoniae YP 005351401.1|Klebsiella pneumoniae

100 99

100 YP 003754127.1|Klebsiella pneumoniae

ZP 08307087.1|Klebsiella sp. MS 92-3 100

83

YP 006958876.1|Klebsiella pneumoniae

86

ZP 16341438.1|Klebsiella pneumoniae YP 003937642.1|Escherichia coli

96

ZP 03035113.1|Escherichia coli F11

99

ZP 16214759.1|Escherichia coli AD30

100

YP 006099192.1|Escherichia coli 042

99

88

99 YP 006902908.1|Escherichia coli

YP 001144261.1|Aeromonas salmonicida A449 YP 002291225.1|Escherichia coli SE11

100

ZP 16217398.1|Serratia phymuthica A30

100

ZP 06193643.1|Serratia odorifera 4Rx13 100

95

99

YP 004119625.1|Pantoea sp. At-9b YP 004118948.1|Pantoea sp. At-9b

100 77

YP 003739382.1|Erwinia billingiae Eb661 YP 006271915.1|Rahnella aquatilis HX2 YP 003993721.1|Photobacterium damselae subsp. damselae 100

ZP 06157864.1|Photobacterium damselae subsp. damselae CIP 102761 YP 008438.1|Candidatus Protochlamydia amoebophila UWE25 ZP 08778726.1|Candidatus Odyssella thessalonicensis L13

100

ZP 08778985.1|Candidatus Odyssella thessalonicensis L13 Reis1 p30 100

90

72

Plasmids

OtsIk0577 OtsIk0709 OtsIk2578-79

69

OtsIk2272-73

100

OtsIk0079-80

99 89

OtsIk0285-86

OtsIk1815-16 75

Rpa0893 Reis1707 Reis0983 89

Chromosomes

Reis1771 67

Reis0906 Rma 0894 66

Reis1020 Ram YP 005365652 Rph0859 RbeRML0514

64

RbeOSU1250 76

Reis0944 Reis3 p38 Reis3 p38 traH familyl 100

0.2

Rra2 p079-81

Plasmids

YP 004119625.1|Pantoea sp. At-9b

88

YP 004118948.1|Pantoea sp. At-9b

98

YP 003739382.1|Erwinia billingiae Eb661 95

77

ML

YP 006271915.1|Rahnella aquatilis HX2 ZP 16217398.1|Serratia phymuthica A30

97

100

ZP 06193643.1|Serratia odorifera 4Rx13 YP 001144261.1|Aeromonas salmonicida A449 100 YP 005351401.1|Klebsiella pneumoniae

87

84

YP 003754127.1|Klebsiella pneumoniae 93

YP 006099192.1|Escherichia coli 042 100 ZP 16214759.1|Escherichia coli AD30

62

YP 003993721.1|Photobacterium damselae subsp. damselae 99 ZP 06157864.1|Photobacterium damselae subsp. damselae CIP 102761

YP 008438.1|Candidatus Protochlamydia amoebophila UWE25 ZP 08778726.1|Candidatus Odyssella thessalonicensis L13

94

ZP 08778985.1|Candidatus Odyssella thessalonicensis L13 Reis1 p30 67

Plasmids

100 OtsIk0577

OtsIk0709

100

Rma 0894 85

60

Reis0906 Rpa0893

86

Ram YP 005365652.1|

Chromosomes

Rph0859 RbeOSU1250 99 RbeRML0514

Reis0944 Reis3 p38 Reis3 p38 traH familyl 100

0.5

Rra2 p079-81

Plasmids

Figure A41. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraN domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 13667088.1|Escherichia coli DEC5B 64

ZP 11675548.1|Escherichia coli EC4100B YP 001965433.1|Escherichia coli

65

YP 006131787.1|Escherichia coli UMNK88 YP 002038906.1|Salmonella enterica str. CVM29188

98

ZP 12042487.1|Escherichia coli 4.0967 ZP 14786192.1|Escherichia coli TW06591

100

NJ

98

68 YP 001739910.1|Escherichia coli SMS-3-5

ZP 08368972.1|Escherichia coli TA271 ZP 14605202.1|Escherichia coli O111:H8 str. CVM9634

85

96 ZP 16889976.1|Escherichia coli H397

ZP 06661259.1|Escherichia coli B088 ZP 15898940.1|Salmonella enterica str. 58-6482

100

99 ZP 13399394.1|Salmonella enterica str. CVM 19443 99

100

YP 006955835.1|Salmonella enterica

70

100

ZP 13422429.1|Salmonella enterica str. CVM 4176

99 NP 490579.1|Salmonella typhimurium LT2

ZP 14619164.1|Escherichia coli O111:H11 str. CVM9553 ZP 06157816.1|Photobacterium damselae CIP 102761 ZP 08778723.1|Candidatus Odyssella thessalonicensis L13

100 99

ZP 08778983.1|Candidatus Odyssella thessalonicensis L13

67

ZP 08778796.1|Candidatus Odyssella thessalonicensis L13 ZP 08829150.1|endosymbiont of Riftia pachyptila (vent (Ph05)

Plasmids

Reis1 p27-28 73

OtsIk1807 OtsIk2576 OtsIk2412

100

100

OtsIk2269 OtsIk2688

Reis1710

97

Chromosomes

Rma 0892 89

90 Reis1018 99

Ram YP 005365654 Reis1773

100 76

Reis0942

81 RbeOSU1248 85 RbeRML0516

Reis3 p36 100

0.2

Rra2 p076-77

Plasmids

ML ZP 14786192.1|Escherichia coli TW06591 87

YP 002038906.1|Salmonella enterica str. CVM29188

100

ZP 13667088.1|Escherichia coli DEC5B

60

ZP 15898940.1|Salmonella enterica str. 58-6482

71

ZP 06157816.1|Photobacterium damselae CIP 102761 Reis3 p36 100

Plasmids

Rra2 p076-77

ZP 08829150.1|endosymbiont of Riftia pachyptila (vent (Ph05) ZP 08778796.1|Candidatus Odyssella thessalonicensis L13 ZP 08778723.1|Candidatus Odyssella thessalonicensis L13

60 100

ZP 08778983.1|Candidatus Odyssella thessalonicensis L13 Reis1 p27-28

71

Plasmids

Rma 0892 Reis1018 100

Ram YP 005365654

69

Reis0942

100 99

Chromosomes

RbeOSU1248

100 RbeRML0516

OtsIk1807 100

0.2

OtsIk2269

Chromosomes

Figure A42. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TrbC_Ftype domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

98 98

ZP 09193289.1|Novosphingobium pentaromativorans US6-1 YP 004534220.1|Novosphingobium sp. PP1Y ZP 10221107.1|Sphingobium indicum B90A ZP 08208934.1|Novosphingobium nitrogenifigens DSM 19370

99

YP 001260253.1|Sphingomonas wittichii RW1 YP 457750.1|Erythrobacter litoralis HTCC2594 100

ZP 01039316.1|Erythrobacter sp. NAP1

YP 345417.1|Rhodobacter sphaeroides 2.4.1 ZP 07343259.1|Burkholderiales bacterium 1 1 47 YP 001853782.1|Vibrio tapetis

92

ZP 05884797.1|Vibrio coralliilyticus ATCC BAA-450 YP 004089556.1|Asticcacaulis excentricus CB 48 100

ZP 08262049.1|Asticcacaulis biprosthecum C19 ZP 02468079.1|Burkholderia thailandensis MSMB43 YP 001110318.1|Burkholderia vietnamiensis G4

100

YP 004980240.1|Burkholderia sp. YI23 ZP 06133179.1|Neisseria gonorrhoeae MS11 ZP 06130990.1|Neisseria gonorrhoeae FA19

100 66

YP 002001698.1|Neisseria gonorrhoeae NCCP11945 ZP 06149026.1|Neisseria gonorrhoeae PID332 ZP 08959140.1|Halomonas sp. HAL1 Reis3 p34

100

Rra2 p074

Pla smids

YP 004662966.1|Simkania negevensis Z YP 008432.1|Candidatus Protochlamydia amoebophila UWE25 ZP 08778722.1|Candidatus Odyssella thessalonicensis L13

82

ZP 08778795.1|Candidatus Odyssella thessalonicensis L13

Pla smids

Reis1 p26 OtsIk2411

90

OtsIk2687 93 99

OtsIk1806

100

OtsIk2114 OtsIk2575 Reis1711

74

Ram_YP 005365617 71

Chromosome s

Reis0913

94 89

Rma 0891 Reis0976 RbeOSU1247 RbeRML0517

100

Reis0941 Reis1017 89

Reis1774

YP 096097.1|Legionella pneumophila 1 YP 003455314.1|Legionella longbeachae NSW150 YP 122317.1|Legionella pneumophila str. Lens 100

ZP 10139264.1|Fluoribacter dumoffii Tex-KL YP 001542677.1|Fluoribacter dumoffii Tex-KL 100

62

ZP 06188943.1|Legionella longbeachae D-4968 YP 003915103.1|Legionella longbeachae NSW150 YP 006271907.1|Rahnella aquatilis HX2

96

ZP 16217401.1|Serratia plymuthica A30 ZP 06641702.1|Serratia odorifera DSM 4582

76 74

ZP 09334038.1|Citrobacter freundii 4 7 47CFAA YP 006957537.1|Salmonella enterica subsp. salamae YP 006964319.1|Salmonella sp. 14

100 95

ZP 12288729.1|Escherichia coli TX1999 ZP 13733002.1|Escherichia coli DEC7D

0.2

Plasmids

Reis1 p26

ML

99 97

OtsIk1806 OtsIk2114

Reis1711

Chromosomes

99 RbeRML0517

Reis0941 Ram_YP 005365617 Rma 0891 ZP 08778722.1|Candidatus Odyssella thessalonicensis L13 ZP 05884797.1|Vibrio coralliilyticus ATCC BAA-450 YP 004089556.1|Asticcacaulis excentricus CB 48 93

ZP 08262049.1|Asticcacaulis biprosthecum C19 YP 004662966.1|Simkania negevensis Z

73

YP 008432.1|Candidatus Protochlamydia amoebophila UWE25 ZP 08959140.1|Halomonas sp. HAL1 Reis3 p34 Plasmids 100

Rra2 p074 100 YP 002001698.1|Neisseria gonorrhoeae NCCP11945

ZP 06130990.1|Neisseria gonorrhoeae FA19 ZP 02468079.1|Burkholderia thailandensis MSMB43 ZP 08208934.1|Novosphingobium nitrogenifigens DSM 19370 ZP 10221107.1|Sphingobium indicum B90A 84

YP 457750.1|Erythrobacter litoralis HTCC2594

60

YP 001260253.1|Sphingomonas wittichii RW1 YP 345417.1|Rhodobacter sphaeroides 2.4.1 90 100

ZP 09334038.1|Citrobacter freundii 4 7 47CFAA YP 006957537.1|Salmonella enterica subsp. salamae ZP 12288729.1|Escherichia coli TX1999

62

62

ZP 06641702.1|Serratia odorifera DSM 4582 YP 006271907.1|Rahnella aquatilis HX2 ZP 10139264.1|Fluoribacter dumoffii Tex-KL YP 001542677.1|Fluoribacter dumoffii Tex-KL

97 60

0.2

YP 003455314.1|Legionella longbeachae NSW150

Figure A43. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraU domain. Bootstrap supports higher than or equal to 60% are shown on the branches. ZP 06861580.1|Citromicrobium bathyomarinum JL354 ZP 08701860.1|Citromicrobium sp. JLT1363

NJ

YP 457062.1|Erythrobacter litoralis HTCC2594

99

YP 457751.1|Erythrobacter litoralis HTCC2594

100 100 100

ZP 01039317.1|Erythrobacter sp. NAP1

ZP 01863184.1|Erythrobacter sp. SD-21 YP 004534221.1|Novosphingobium sp. PP1Y 99

ZP 10221106.1|Sphingobium indicum B90A ZP 10871955.1|Sphingomonas sp. LH128 ZP 09910834.1|Sphingobium yanoikuyae XLDN2-5

85

YP 001260252.1|Sphingomonas wittichii RW 1

100 74

ZP 09195012.1|Novosphingobium pentaromativorans US6-1

75

ZP 09139089.1|Sphingomonas sp. KC8

94 99

ZP 10340137.1|Sphingomonas echinoides ATCC 14820 ZP 10746347.1|Novosphingobium sp. AP12

100

ZP 10747343.1|Novosphingobium sp. AP12 ZP 10341902.1|Sphingomonas echinoides ATCC 14820 NP 049157.1|Novosphingobium aromaticivorans

68 100

YP 718073.1|Sphingomonas sp. KA1 YP 003853355.1|Parvularcula bermudensis HTCC2503

63

YP 004089555.1|Asticcacaulis excentricus CB 48 100

ZP 08262048.1|Asticcacaulis biprosthecum C19 YP 345416.1|Rhodobacter sphaeroides 2.4.1 100

ref|NC 007490.1| Rhodobacter sphaeroides 2.4.1

YP 285858.1|Dechloromonas aromatica RCB

100 100

YP 285531.1|Dechloromonas aromatica RCB YP 004487070.1|Delftia sp. Cs1-4 YP 003846738.1|Gallionella capsiferriformans ES-2

100

100 100 100

86

YP 001840935.1|Acinetobacter baumannii ACICU ZP 15906938.1|Acinetobacter baumannii IS-123 YP 006291711.1|Acinetobacter baumannii MDR-TJ ZP 06064633.1|Acinetobacter johnsonii SH046

ZP 02468078.1|Burkholderia thailandensis MSMB43

98

82

YP 002235468.1|Burkholderia cenocepacia J2315 YP 974010.1|Acidovorax sp. JS42

100

97

YP 004030626.1|Burkholderia rhizoxinica HKI 454 YP 002913230.1|Burkholderia glumae BGR1 100 87

YP 840428.1|Burkholderia cenocepacia HI2424 YP 004350946.1|Burkholderia gladioli BSR3

YP 096098.1|Legionella pneumophila 1 NP 490576.1|Salmonella typhimurium LT2

99

YP 001144256.1|Aeromonas salmonicida subsp. salmonicida A449

100 100

ZP 12963920.1|Aeromonas salmonicida 01-B526

Rra2 p072-73

Pla smids

Reis3 p33

100 89

Ram32 p50-52

ZP 08778721.1|Candidatus Odyssella thessalonicensis L13

100

ZP 08778981.1|Candidatus Odyssella thessalonicensis L13

Pla smids

Reis1 p25 65

Reis1712 Reis0975

65

Reis1015 99

99

Reis0914

76

Ram NC 017028 Rma 0890

Chromosome s

Reis1776 RbeOSU1246 100

80

RbeRML0518 100

Reis0940 78 96 65

OtsIk0146 OtsIk0990 OtsIk2410

OtsIk2574 OtsIk1805 100

OtsIk0190

0.1

Chromosome s

YP 457062.1|Erythrobacter litoralis HTCC2594 100

ML

ZP 08701860.1|Citromicrobium sp. JLT1363

83

ZP 06861580.1|Citromicrobium bathyomarinum JL354

89

ZP 09910834.1|Sphingobium yanoikuyae XLDN2-5 NP 049157.1|Novosphingobium aromaticivorans

63

YP 003853355.1|Parvularcula bermudensis HTCC2503 YP 004089555.1|Asticcacaulis excentricus CB 48 YP 345416.1|Rhodobacter sphaeroides 2.4.1 95

YP 285858.1|Dechloromonas aromatica RCB

100

YP 285531.1|Dechloromonas aromatica RCB YP 004487070.1|Delftia sp. Cs1-4 YP 003846738.1|Gallionella capsiferriformans ES-2

100

YP 001840935.1|Acinetobacter baumannii ACICU

86

YP 840428.1|Burkholderia cenocepacia HI2424

92 86

YP 974010.1|Acidovorax sp. JS42 59 Reis3 p33 100

Ram32 p50-52

Plasmids

Rra2 p072-73 YP 096098.1|Legionella pneumophila 1 NP 490576.1|Salmonella typhimurium LT2

100

YP 001144256.1|Aeromonas salmonicida subsp. salmonicida A449

100 100

ZP 12963920.1|Aeromonas salmonicida 01-B526

ZP 08778721.1|Candidatus Odyssella thessalonicensis L13

Plasmids Chromosomes

Reis1 p25 100

OtsIk0146 Ram NC 017028

100 96 65

Rma 0890 RbeRML0518 100 Reis0940

0.1

Chromosomes

Figure A44. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraC_F_IV and AAA_10 domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

78 ZP 01039322.1|Erythrobacter sp. NAP1

NJ

60 YP 457756.1|Erythrobacter litoralis HTCC2594 100 85 100

YP 457067.1|Erythrobacter litoralis HTCC2594 ZP 06861585.1|Citromicrobium bathyomarinum JL354 ZP 08701865.1|Citromicrobium sp. JLT1363 ZP 09192858.1|Novosphingobium pentaromativorans US6-1

99

100 ZP 01864954.1|Erythrobacter sp. SD-21 100

YP 004534226.1|Novosphingobium sp. PP1Y ZP 09910840.1|Sphingobium yanoikuyae XLDN2-5

100

ZP 10340131.1|Sphingomonas echinoides ATCC 14820

100

YP 001260246.1|Sphingomonas wittichii RW1

80

100 ZP 10873136.1|Sphingomonas sp. LH128

YP 003853360.1|Parvularcula bermudensis HTCC2503

69

100 ZP 08829156.1|endosymbiont of Riftia pachyptila (vent Ph05) 98

ZP 08829156.1|endosymbiont of Riftia pachyptila (vent Ph05)(2) ref|NZ CH724124.1| Oceanobacter sp.

90

ref|NC 014723.1| Burkholderia rhizoxinica HKI 454 plasmid pBRH02 ref|NZ JH815242.1| Ralstonia sp. 5 2 56FAA genomic scaffold

100

100 ref|NC 015423.1| Alicycliphilus denitrificans K601 plasmid pALIDE201

ZP 09865829.1|Thiorhodovibrio sp. 970 YP 008429.1|Candidatus Protochlamydia amoebophila UWE25

75

ZP 08778788.1|Candidatus Odyssella thessalonicensis L13 ZP 08778979.1|Candidatus Odyssella thessalonicensis L13 Reis1 p23

Plasmids

100 OtsIk0142

100

86 95

100

OtsIk0994 OtsIk2571 OtsIk0193 Reis1715

89

Reis0971-72 100

Rma 0885

100

Reis1779 100

Chromosomes

Reis0918-19 Reis1012 Reis0937 REIS 0850 conjugative Rmo850164

90

RbeOSU1243 100

RbeRML0521 Reis3 p30 100

0.2

Rra2 p063-064

Plasmids

YP 457756.1|Erythrobacter litoralis HTCC2594

ML

90 100

ZP 06861585.1|Citromicrobium bathyomarinum JL354 YP 457067.1|Erythrobacter litoralis HTCC2594

100

ZP 09192858.1|Novosphingobium pentaromativorans US6-1 ZP 10340131.1|Sphingomonas echinoides ATCC 14820

100 100

ZP 09910840.1|Sphingobium yanoikuyae XLDN2-5 YP 003853360.1|Parvularcula bermudensis HTCC2503

82

ZP 08829156.1|endosymbiont of Riftia pachyptila (vent Ph05) ZP 09865829.1|Thiorhodovibrio sp. 970 67

ref|NC 014723.1| Burkholderia rhizoxinica HKI 454

69

NZ JH815242.1| Ralstonia sp. 5 2 56FAA

100

100 NC 015423.1| Alicycliphilus denitrificans K601

ZP 08778979.1|Candidatus Odyssella thessalonicensis L13 Reis1 p23

100

Plasmids

OtsIk0142

100

Rma 0885

86 98

Reis1779

Chromosomes

RbeRML0521 100 Rmo850164

YP 008429.1|Candidatus Protochlamydia amoebophila UWE25 Reis3 p30 100

0.2

Rra2 p063-064

Plasmids

Figure A45. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraE domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

Plasmids

Reis1 p17 OtsIk0312

NJ

78 OtsIk2124 65

OtsIk2566

77 OtsIk2678

OtsIk2400 100

OtsIk1330 OtsIk1798 OtsIk1726 96

OtsIk0593 73

OtsIk1426 OtsIk2260

77 OtsIk2471

86

Chromosomes

100 Reis1721

Reis2068 Reis0924

63

Rpe0195 100

Rma 0880 Reis1784 Reis1007 RbeOSU1238 RbeRML0526 98 Reis0932

Rmo850159 ZP 08778974.1|Candidatus Odyssella thessalonicensis L13 YP 899950.1|Pelobacter propionicus DSM 2379

0.2

ML

Plasmids

Reis1 p17 OtsIk0312

98

96 RbeRML0526

Rmo850159 91

60

Rpe0195

Chromosomes

Rma 0880 88

Reis0924

ZP 08778974.1|Candidatus Odyssella thessalonicensis L13 YP 899950.1|Pelobacter propionicus DSM 2379

0.2

Figure A46. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TrbI domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

Plasmids

Reis1 p22 OtsIk0589 OTT 0415 putative conjugative

100 100

OtsIk2569 RbeOSU1241

NJ

99 RbeRML0523 96

Reis0935

Chromosomes

Rmo850162 99

86 Rma 0883

100

Rpe0192 Reis0921 Reis1010 62 Reis1781

ZP 08778717.1|Ca. Odyssella thessalonicensis L13 Reis3 p28 100

Rra2 p061

Plasmids

ZP 08778786.1|Ca. Odyssella thessalonicensis L13 YP 008424.1|Candidatus Protochlamydia amoebophila UWE25 ZP 01308485.1|Bermanella marisrubri ZP 04808134.1|Helicobacter pullorum MIT 98-5489

100

ZP 04808954.1|Helicobacter pullorum MIT 98-5489 ZP 09777240.1|Succinivibrionaceae bacterium WG-1 YP 005352478.1|Photobacterium damselae subsp. damselae 98

ZP 09865696.1|Thiorhodovibrio sp. 970 ZP 11114484.1|Pseudomonas mandelii JR-1

89

NP 758672.1|Pseudomonas resinovorans 100

YP 003617136.1|Pseudomonas putida YP 001393138.1|Vibrio vulnificus

63 74

NP 762588.1|Vibrio vulnificus CMCP6 YP 002261496.1|Aliivibrio salmonicida LFI1238

100

YP 006022867.1|Shewanella baltica BA175 92

100

YP 001556954.1|Shewanella baltica OS195

99 YP 002364263.1|Shewanella baltica OS223

ZP 12658882.1|Candidatus Regiella insecticola R5.15 68 100

YP 160802.1|Aromatoleum aromaticum EbN1 YP 285523.1|Dechloromonas aromatica RCB YP 004388669.1|Alicycliphilus denitrificans K601 ZP 06153507.1|Neisseria gonorrhoeae SK-93-1035

89

gi|254674167|emb|CBA09951.1|Neisseria meningitidis alpha275 100 YP 002001706.1|Neisseria gonorrhoeae NCCP11945

ZP 06130982.1|Neisseria gonorrhoeae FA19

0.5

ML

Plasmids

Reis1 p22 100

OtsIk2569 96 RbeRML0523 92

Rmo850162

93

77 100

Chromosomes

Rma 0883 Rpe0192

66

Reis0921

ZP 08778717.1|Candidatus Odyssella thessalonicensis L13 YP 008424.1|Candidatus Protochlamydia amoebophila UWE25 100

Reis3 p28 Rra2 p061

Plasmids

ZP 12658882.1|Candidatus Regiella insecticola R5.15

66

YP 001556954.1|Shewanella baltica OS195

79

YP 002261496.1|Aliivibrio salmonicida LFI1238

100

YP 001393138.1|Vibrio vulnificus

73 67

NP 762588.1|Vibrio vulnificus CMCP6

ZP 01308485.1|Bermanella marisrubri NP 758672.1|Pseudomonas resinovorans ZP 09777240.1|Succinivibrionaceae bacterium WG-1

100

YP 005352478.1|Photobacterium damselae subsp. damselae

91

ZP 09865696.1|Thiorhodovibrio sp. 970 ZP 04808134.1|Helicobacter pullorum MIT 98-5489 100 YP 002001706.1|Neisseria gonorrhoeae NCCP11945

ZP 06130982.1|Neisseria gonorrhoeae FA19 ZP 04765243.1|Acidovorax delafieldii 2AN

84

YP 004388669.1|Alicycliphilus denitrificans K601 94

YP 160802.1|Aromatoleum aromaticum EbN1 79

0.5

YP 285523.1|Dechloromonas aromatica RCB

Figure A47. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative coupling protein containing TrwB and TraD_N domains. Bootstrap supports higher than or equal to 60% are shown on the branches. ZP 13078758.1|Salmonella enterica str. ATCC 10729 ZP 09334030.1|Citrobacter freundii 4 7 47CFAA YP 006964312.1|Salmonella sp. 14 94

ZP 10411274.1|Enterobacter sp. Ag1 ZP 02347590.2|Salmonella enterica str. SARA29 YP 004193480.1|Salmonella enterica str. 2007-60-3289-1

NJ

ZP 13360763.1|Salmonella enterica str. CVM 35202 YP 001451442.1|Escherichia coli E24377A

99 99 98

ZP 03062936.1|Escherichia coli B171

ZP 12918178.1|Escherichia coli UMNF18 94

ZP 12288739.1|Escherichia coli TX1999

100

YP 001144264.1|Aeromonas salmonicida subsp. salmonicida A449 YP 004831101.1|Serratia marcescens YP 001481211.1|Escherichia coli APEC O1 92

ZP 12077701.1|Escherichia coli B41 100

YP 003237809.1|Escherichia coli O111:H- str. 11128

73

YP 002038895.1|Salmonella enterica str. CVM29188 ZP 08351680.1|Escherichia coli M605

100

YP 003232540.1|Escherichia coli O26:H11 str. 11368 ZP 03030169.1|Escherichia coli B7A ZP 11643209.1|Shigella dysenteriae CDC 74-1112 ZP 07119168.1|Escherichia coli MS 198-1 YP 003455307.1|Legionella longbeachae NSW150

100

YP 122324.1|Legionella pneumophila str. Lens ZP 06157866.1|Photobacterium damselae CIP 102761

100 100

ZP 06157979.1|Photobacterium damselae CIP 102761 ZP 06157813.1|Photobacterium damselae CIP 102761 YP 001393154.1|Vibrio vulnificus

98

YP 015473.1|Photobacterium profundum SS9

78

YP 002360273.1|Shewanella baltica OS223

100

YP 002360331.1|Shewanella baltica OS223

100 74

YP 002364248.1|Shewanella baltica OS223 YP 005516307.1|Acinetobacter baumannii 16562

100

ZP 08778990.1|Candidatus Odyssella

90

ZP 08778731.1|Candidatus Odyssella thessalonicensis L13 ZP 08778801.1|Candidatus Odyssella YP 008440.1|Candidatus Protochlamydia amoebophila UWE25 Reis3 p41

98

Rra3 p23

100

Rra2 p087-88

84

Pla smids

Rhe p10-p13

83

Rfe p59-60 82

RfeI1 p60-61

100

Pla smids

Rfe pd26-27 Reis1 p35

Reis1701 OtsBo1520-21

100

OtsBo0867-68 100

OtsBo2840-41 OtsBo0160 OtsBo2754

Reis0989

98

Ram NC 017028 Rpa0889 RbeRML0511 88

Chromosome s

Reis0947 Rmo850166 Rph0862 Reis1023 Rma 0897 Reis0900 Ram YP 005365649 Ram YP 005365669 Reis1765-66 conjugative Reis0386-87 71

0.2

Rhe0961-63

Reis1 p35 100

ML

Rfe pd26-27 Rfe p59-60

Plasmids

100

100

RfeI1 p60-61 OtsBo0160 Rhe0961-63 98

Rma 0897 Rmo850166

97

100 Rph0862

61

Chromosomes

Reis0947

93

RbeRML0511 Rpa0889 Reis0900 Ram YP 005365649 YP 005516307.1|Acinetobacter baumannii 16562 YP 002360273.1|Shewanella baltica OS223

100

YP 015473.1|Photobacterium profundum SS9 99

YP 001393154.1|Vibrio vulnificus ZP 06157813.1|Photobacterium damselae CIP 102761 YP 003455307.1|Legionella longbeachae NSW150

100

YP 004831101.1|Serratia marcescens

99 66

ZP 11643209.1|Shigella dysenteriae CDC 74-1112 YP 001144264.1|Aeromonas salmonicida subsp. salmonicida A449

100

ZP 12918178.1|Escherichia coli UMNF18

100

ZP 13360763.1|Salmonella enterica str. CVM 35202

100 83

ZP 13078758.1|Salmonella enterica str. ATCC 10729

100 ZP 09334030.1|Citrobacter freundii 4 7 47CFAA 100

ZP 08778990.1|Candidatus Odyssella thessalonicensis L13 ZP 08778731.1|Candidatus Odyssella thessalonicensis L13 YP 008440.1|Candidatus Protochlamydia amoebophila UWE25

63

59 90

Rra3 p23 100 97

0.2

Reis3 p41

Rra2 p087-88 Rhe p10-p13

Plasmids

Figure A48. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraF domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

Reis1 p29 51

NJ

Plasmids

Reis1772

48

Rma 0893 Rpa0894

79

Reis1019

100 99

Ram YP 005365653 93

RbeOSU1249

84

RbeRML0515 100

Reis0943 Ram YP 005365618 Reis1708 72

OtsIk0579 100 86

OtsIk0707 OtsIk2270 OtsIk2577

84

38

Chromosomes

OtsIk1230 48

OtsIk1620 99

OtsIk2111 100

OtsIk2413 OtsIk0297

100

OtsIk2690 ZP 08778724.1|Candidatus Odyssella thessalonicensis L13

100

ZP 08778984.1|Candidatus Odyssella thessalonicensis L13 NP 049153.1|Novosphingobium aromaticivorans

84 100

ZP 09910829.1|Sphingobium yanoikuyae XLDN2-5

26

ZP 10747337.1|Novosphingobium sp. AP12 ZP 08778797.1|Candidatus Odyssella thessalonicensis L13 ZP 01451142.1|Mariprofundus ferrooxydans PV-1

100

100 40

35

YP 160814.1|Aromatoleum aromaticum EbN1 YP 285862.1|Dechloromonas aromatica RCB YP 004030631.1|Burkholderia rhizoxinica HKI 454

gi|254674176|emb|CBA09960.1|Neisseria meningitidis alpha275

67 100

YP 002001694.1|Neisseria gonorrhoeae NCCP11945

98 ZP 06130994.1|Neisseria gonorrhoeae FA19 43 ZP 06135527.1|Neisseria gonorrhoeae PID18

0.2

ML

Reis1 p29 100

Plasmids

OtsIk0297 Rpa0894 98

Ram YP 005365618 84

Rma 0893 81

Chromosomes

RbeRML0515 100 Reis0943

ZP 08778724.1|Candidatus Odyssella thessalonicensis L13 100

ZP 08778984.1|Candidatus Odyssella thessalonicensis L13 ZP 01451142.1|Mariprofundus ferrooxydans PV-1 NP 049153.1|Novosphingobium aromaticivorans

100 97

ZP 09910829.1|Sphingobium yanoikuyae XLDN2-5 ZP 08778797.1|Candidatus Odyssella thessalonicensis L13 gi|254674176|emb|CBA09960.1|Neisseria meningitidis alpha275

86

YP 004030631.1|Burkholderia rhizoxinica HKI 454 67

YP 160814.1|Aromatoleum aromaticum EbN1 100

0.2

YP 285862.1|Dechloromonas aromatica RCB

Figure A49. Neighbor-joining (NJ) and maximum likelihood (ML) trees of helicases RecD/TraA containing AAA_30 and UvrD_C_2 domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 02190744.1|alpha proteobacterium BAL199

100 84

ZP 02191403.1|alpha proteobacterium BAL199

96

NJ

ZP 02192076.1|alpha proteobacterium BAL199

99

YP 578071.1|Nitrobacter hamburgensis X14 ZP 08073657.1|Methylocystis sp. ATCC 49242

98

ZP 05054956.1|Octadecabacter antarcticus 307

100

ZP 05064957.1|Octadecabacter arcticus 238 ZP 01048465.1|Nitrobacter sp. Nb-311A

100

76

ZP 01903329.1|Roseobacter sp. AzwK-3b

100 100

ZP 05065242.1|Octadecabacter arcticus 238 YP 001220283.1|Acidiphilium cryptum JF-5 YP 001220030.1|Acidiphilium cryptum JF-5

100 65

ZP 08634959.1|Acidiphilium sp. PM ZP 01085074.1|Synechococcus sp. WH 5701

100

ZP 07972826.1|Synechococcus sp. CB0101 ZP 09997940.1|Acidithiobacillus YP 004748470.1|Acidithiobacillus caldus SM-1

100 100

ZP 05293745.1|Acidithiobacillus caldus ATCC 51756 ZP 10178777.1|Microvirga sp. WSM3557

98 100

gi|390189957|emb|CCD32190.1|Methylocystis sp. SC2 YP 005030922.1|Azospirillum brasilense Sp245 ZP 08900128.1|Gluconacetobacter oboediens 174Bp2 YP 002275391.1|Gluconacetobacter diazotrophicus PAl 5

95

YP 001601244.1|Gluconacetobacter diazotrophicus PAl 5 98

ZP 08318929.1|Gluconacetobacter sp. SXCC-1

100

YP 001603050.1|Gluconacetobacter diazotrophicus PAl 5

61

YP 003189342.1|Acetobacter pasteurianus IFO 3283-01

76 100

YP 005492189.1|Acetobacter pasteurianus IFO 3283-12 YP 005479406.1|Acetobacter pasteurianus IFO 3283-03

96

gi|398058813|gb|EJL50695.1|Burkholderia sp. BT03 100

YP 003165615.1|Ca. Accumulibacter phosphatis clade IIA str. UW-1 ZP 10114476.1|Beggiatoa alba B18LD ZP 09865796.1|Thiorhodovibrio sp. 970

100 98

ZP 09866112.1|Thiorhodovibrio sp. 970

99 67

ZP 08821817.1|Thiorhodococcus drewsii AZ1 YP 003761194.1|Nitrosococcus watsonii C-113 ZP 09865674.1|Methylomicrobium album BG8 YP 379155.1|Chlorobium chlorochromatii CaD3

85

YP 901533.1|Pelobacter propionicus DSM 2379

62 99

YP 002018300.1|Pelodictyon phaeoclathratiforme BU-1 YP 899880.1|Pelobacter propionicus DSM 2379 100

YP 001950493.1|Geobacter lovleyi SZ ZP 08778308.1|Candidatus Odyssella thessalonicensis L13

92

Reis2 p04 Reis2 p88 Rmo p15

70 100

Plasmids

Ram32 p34 Rau p21-25 Rra2 p109 97

Rhe p30 OtsBo0525 100

0.1

OtsIk0118

ZP 05054956.1|Octadecabacter antarcticus 307

100 100

ML

ZP 05064957.1|Octadecabacter arcticus 238

80

ZP 01903329.1|Roseobacter sp. AzwK-3b YP 578071.1|Nitrobacter hamburgensis X14

61

YP 001220283.1|Acidiphilium cryptum JF-5 ZP 01085074.1|Synechococcus sp. WH 5701

66

ZP 05293745.1|Acidithiobacillus caldus ATCC 51756 ZP 10178777.1|Microvirga sp. WSM3557 YP 001603050.1|Gluconacetobacter diazotrophicus PAl 5 94

YP 003189342.1|Acetobacter pasteurianus IFO 3283-01

100

100 YP 005479406.1|Acetobacter pasteurianus IFO 3283-03

84

YP 005030922.1|Azospirillum brasilense Sp245 gi|398058813|gb|EJL50695.1|Burkholderia sp. BT03 100

86

YP 003165615.1|Ca. Accumulibacter phosphatis clade IIA str. UW-1 ZP 10114476.1|Beggiatoa alba B18LD ZP 08821817.1|Thiorhodococcus drewsii AZ1

99 78

100

ZP 09865796.1|Thiorhodovibrio sp. 970 YP 003761194.1|Nitrosococcus watsonii C-113 ZP 09865674.1|Methylomicrobium album BG8

83

YP 001950493.1|Geobacter lovleyi SZ

90

YP 901533.1|Pelobacter propionicus DSM 2379

100

YP 002018300.1|Pelodictyon phaeoclathratiforme BU-1 73

YP 379155.1|Chlorobium chlorochromatii CaD3 100

79

OtsBo0525 OtsIk0118

ZP 08778308.1|Candidatus Odyssella thessalonicensis L13 98 Reis2 p04

Reis2 p88 75 100

Rmo p15 Ram32 p34 Rau p21-25

68

Rra2 p109 99 Rhe p30

0.1

Plasmids

Figure A50. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer relaxase TraA_Ti containing MobA/MobL and AAA_30 domains. Bootstrap supports higher than

or equal to 60% are shown on the branches.

NJ

YP 004612955.1|Mesorhizobium opportunistum WSM2075

100

YP 004614016.1|Mesorhizobium opportunistum WSM2075

99

YP 006591992.1|Methylocystis sp. SC2 95

YP 534361.1|Rhodopseudomonas palustris BisB18

99

ZP 10541298.1|Sphingobium sp. AP49

ZP 09909078.1|Sphingobium yanoikuyae XLDN2-5 93

78

ZP 09906625.1|Sphingobium yanoikuyae XLDN2-5 YP 611123.1|Sphingopyxis alaskensis RB2256

65

100

ZP 00953568.1|Oceanicaulis alexandrii HTCC2633 ZP 10422497.1|Sphingomonas sp. PAMC 26617

94

ZP 10543064.1|Sphingobium sp. AP49 88

YP 001682780.1|Caulobacter sp. K31 YP 001681961.1|Caulobacter sp. K31

100

100 YP 001681961.1|Caulobacter sp. K31(2) 72

ZP 10875836.1|Sphingomonas sp. LH128 ZP 10423193.1|Sphingomonas sp. PAMC 26617 NC 011367.1| Gluconacetobacter diazotrophicus PAl 5 100

YP 002278358.1|Gluconacetobacter diazotrophicus PAl 5 YP 001542686.1|Fluoribacter dumoffii Tex-KL YP 002551269.1|Agrobacterium radiobacter K84 99

ZP 06705668.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 EJK08567.1|Klebsiella pneumoniae subsp. pneumoniae KPNIH18 YP 004087289.1|Asticcacaulis excentricus CB 48

71

ZP 11265645.1|Rhizobium mesoamericanum STM3625

100

ZP 08666465.1|Paracoccus sp. TRP

97

YP 003329392.1|Sinorhizobium meliloti

100

NP 355808.2|Agrobacterium fabrum str. C58

100 100 99

YP 004442864.1|Agrobacterium sp. H13-3 YP 004443114.1|Agrobacterium sp. H13-3 Reis2 p89-93-94 66 98 100

Rra2 p001-112 Rhe p31-33 Rra1 p26-28 Reis2 p67-68 Ram32 p41-46

66

Reis1 p66 Reis3 p01 100 66

Plasmids

Rra2 p101 Rhe p21-25 Rau p30-33 Rra3 p14 RfeI1 p54-57

100 92

Rfe p54-56 Rfe pd22-23 ZP 08778730.1|Candidatus Odyssella thessalonicensis L13

100

0.5

ZP 08778989.1|Candidatus Odyssella thessalonicensis L13

Reis1 p66

60

Reis3 p01 Rra3 p14

ML

Reis2 p67-68 RfeI1 p54-57 100

Rfe p54-56

100 Rfe pd22-23 100

Rra2 p101

Plasmids

Rhe p21-25 Rau p30-33

10061

Ram32 p41-46

68

Reis2 p89-93-94 Rra2 p001-112 100 80 100

Rhe p31-33 Rra1 p26-28

YP 004442864.1|Agrobacterium sp. H13-3 YP 003329392.1|Sinorhizobium meliloti

98

ZP 11265645.1|Rhizobium mesoamericanum STM3625

100

ZP 08666465.1|Paracoccus sp. TRP

82

YP 004087289.1|Asticcacaulis excentricus CB 48 ZP 06705668.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 100 EJK08567.1|Klebsiella pneumoniae subsp. pneumoniae KPNIH18

YP 001542686.1|Fluoribacter dumoffii Tex-KL YP 002278358.1|Gluconacetobacter diazotrophicus PAl 5 84

ZP 10422497.1|Sphingomonas sp. PAMC 26617 85

YP 006591992.1|Methylocystis sp. SC2

100 98

YP 534361.1|Rhodopseudomonas palustris BisB18 ZP 09909078.1|Sphingobium yanoikuyae XLDN2-5

79

YP 611123.1|Sphingopyxis alaskensis RB2256

66 100

0.2

ZP 00953568.1|Oceanicaulis alexandrii HTCC2633

Figure A51. Neighbor-joining (NJ) and maximum likelihood (ML) trees of topoisomerase. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 98 ZP 08243050.1|Acetobacter pomorum DM001

YP 003187381.1|Acetobacter pasteurianus IFO 3283-01 92

ZP 08899413.1|Gluconacetobacter oboediens 174Bp2

93

YP 001603827.1|Gluconacetobacter diazotrophicus PAl 5 YP 001767798.1|Methylobacterium sp. 4-46

81

YP 001691297.1|Methylobacterium sp. 4-46 ZP 05083554.1|Pseudovibrio sp. JE062

100 93

YP 005082428.1|Pseudovibrio sp. FO-BEG1 ZP 11317471.1|Desulfovibrio magneticus str. Maddingley MBC34 ZP 08902197.1|Gluconacetobacter europaeus LMG 18494

98 99

YP 002276834.1|Gluconacetobacter diazotrophicus PAl 5 ZP 05318230.1|Neisseria sicca ATCC 29256 YP 003082996.1|Neisseria meningitidis alpha14

98

ZP 03719908.1|Neisseria flavescens NRL30031/H210

100

91 YP 005893741.1|Neisseria meningitidis G2136 83 YP 974931.1|Neisseria meningitidis FAM18

ZP 08177296.1|Xanthomonas vesicatoria ATCC 35937 ZP 10035856.1|Burkholderia sp. Ch1-1 ZP 01045524.1|Nitrobacter sp. Nb-311A YP 004695588.1|Nitrosomonas sp. Is79A3 Reis3 p01 Reis1 p66 99

Reis3 p45 99

Ram23 p46-50-p01-04 91

Ram32 p41-46 Rra3 p14

95

Rau p30-33

Plasmids

82 78 Rra2 p101 66 Rhe p21-25

RfeI1 p81-84

79 100

Rfe pd48-49

91 Rfe p81-82

ZP 00680231.1|Xylella fastidiosa Ann-1 65 NP 779794.1|Xylella fastidiosa Temecula1

YP 004662923.1|Simkania negevensis Z

0.5

90 Rfe pd48-49 100

Rfe p81-82 RfeI1 p81-84 Rra2 p101

65 98 Rhe p21-25

ML

Rau p30-33 Ram23 p46-50-p01-04

69 78 97

Plasmids

Ram32 p41-46 Rra3 p14 Reis1 p66 Reis3 p45 Reis3 p01 YP 004695588.1|Nitrosomonas sp. Is79A3

79

YP 005893741.1|Neisseria meningitidis G2136 ZP 11317471.1|Desulfovibrio magneticus str. Maddingley MBC34

100

ZP 08902197.1|Gluconacetobacter europaeus LMG 18494 ZP 10035856.1|Burkholderia sp. Ch1-1 ZP 01045524.1|Nitrobacter sp. Nb-311A ZP 05083554.1|Pseudovibrio sp. JE062

99 69

YP 001691297.1|Methylobacterium sp. 4-46 YP 001767798.1|Methylobacterium sp. 4-46

77

ZP 08899413.1|Gluconacetobacter oboediens 174Bp2

95 97

ZP 08243050.1|Acetobacter pomorum DM001

YP 004662923.1|Simkania negevensis Z

0.5

Figure A52. Neighbor-joining (NJ) and maximum likelihood (ML) trees of WGR domaincontaining protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

59

Reis2 p03 Ram32 p35

62

Rhe p28

NJ

100 Rra2 p108 75

Rau p26 Rfe p85

P la smids

Rfe pd52

99 99

RfeI1 p87 Rfe p48 98 RfeI1 p49

YP 436801.1|Hahella chejuensis KCTC 2396 WP 007191292.1|Thiocapsa marina

0.2

Rfe pd52 99

ML

RfeI1 p87 Rfe p85

Rau p26 Reis2 p03 Ram32 p35 94

Plasmids

Rhe p28 100 Rra2 p108

Rfe p48 97 RfeI1 p49

YP 436801.1|Hahella chejuensis KCTC 2396 WP 007191292.1|Thiocapsa marina

0.2

Figure A53. Neighbor-joining (NJ) and maximum likelihood (ML) trees of WGR domaincontaining protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 088012.1|Mannheimia succiniciproducens MBEL55E

NJ

YP 001344384.1|Actinobacillus succinogenes 130Z YP 004823117.1|Haemophilus parainfluenzae T3T1 EGY33536.1|Aggregatibacter actinomycetemcomitans str. SC1083 78

ZP 06640677.1|Serratia odorifera DSM 4582 YP 004620901.1|Ramlibacter tataouinensis TTB 310 ZP 09295345.1|Mesorhizobium alhagi CCNWXJ12-2 YP 006316304.1|Francisella noatunensis str. Toba 04 WP 022950793.1|Leucothrix mucor

61

WP 004027524.1|Escherichia coli 66

WP 001651019.1|Salmonella enterica

WP 009288665.1|Halomonas titanica Reis1 p04 88

Rpe p32 80

Rra2 p028

Plasmids

Reis1 p52 Rmo p01-02

83

Rra3 p04-09 72

0.5

Reis3 p07

Rmo p01-02 Reis1 p52

ML

Rra3 p04-09 60

71

Reis3 p07

Plasmids

Reis1 p04 76 60

Rpe p32 Rra2 p028 WP 009288665.1|Halomonas titanica YP 004620901.1|Ramlibacter tataouinensis TTB 310

ZP 09295345.1|Mesorhizobium alhagi CCNWXJ12-2 ZP 06640677.1|Serratia odorifera DSM 4582

64

EGY33536.1|Aggregatibacter actinomycetemcomitans str. SC1083 63

YP 004823117.1|Haemophilus parainfluenzae T3T1 YP 088012.1|Mannheimia succiniciproducens MBEL55E YP 001344384.1|Actinobacillus succinogenes 130Z YP 006316304.1|Francisella noatunensis str. Toba 04 WP 022950793.1|Leucothrix mucor WP 004027524.1|Escherichia coli

84

0.5

WP 001651019.1|Salmonella enterica

Figure

A54.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

transposase/integrase containing HTH_21 and rve domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ Rpe p19-20 Rma 0911 Reis4 p160059-60 100

Plasmids and chromosomes

Rra3 p19

67

Rra0752-53 ZP 05070602.1|Sulfurimonas gotlandica GD1

91

100

YP 003892090.1|Sulfurimonas autotrophica DSM 16294 YP 748379.1|Nitrosomonas eutropha C91

100 ZP 08779560.1|Methylobacter tundripaludum SV96 100

ZP 08782723.1|Methylobacter tundripaludum SV96

82 60

YP 004295491.1|Nitrosomonas sp. AL212 ZP 09862550.1|Methylomicrobium album BG8 YP 866546.1|Magnetococcus marinus MC-1 YP 865897.1|Magnetococcus marinus MC-1

100 95

YP 865048.1|Magnetococcus marinus MC-1

YP 001520848.1|Acaryochloris marina MBIC11017 ZP 01464534.1|Stigmatella aurantiaca DW4/3-1 ZP 06969084.1|Ktedonobacter racemifer DSM 44963 YP 003020241.1|Geobacter sp. M21 YP 002509121.1|Halothermothrix orenii H 168 YP 003993904.1|Halanaerobium hydrogeniformans

100 100 100 94

YP 005836365.1|Halanaerobium praevalens DSM 2228

YP 002505817.1|Clostridium cellulolyticum H10 YP 002505891.1|Clostridium cellulolyticum H10 YP 002316720.1|Anoxybacillus flavithermus WK1

81

NP 286669.1|Escherichia coli O157:H7 str. EDL933 YP 003505358.1|Denitrovibrio acetiphilus DSM 12809

100 100

0.1

YP 003503412.1|Denitrovibrio acetiphilus DSM 12809

76

Rpe p19-20 Rra0752-53

NJ

100

Plasmids and chromosomes

Rma 0911 Rra3 p19

67

Reis4 p160059-60 ZP 05070602.1|Sulfurimonas gotlandica GD1

88

100

YP 003892090.1|Sulfurimonas autotrophica DSM 16294

100 ZP 08779560.1|Methylobacter tundripaludum SV96

ZP 08782723.1|Methylobacter tundripaludum SV96 ZP 09862550.1|Methylomicrobium album BG8

100

84

YP 004295491.1|Nitrosomonas sp. AL212

59

YP 748379.1|Nitrosomonas eutropha C91 YP 866546.1|Magnetococcus marinus MC-1 100

YP 865897.1|Magnetococcus marinus MC-1

98 YP 865048.1|Magnetococcus marinus MC-1

YP 003020241.1|Geobacter sp. M21 ZP 01464534.1|Stigmatella aurantiaca DW4/3-1 YP 001520848.1|Acaryochloris marina MBIC11017 YP 002509121.1|Halothermothrix orenii H 168 YP 003993904.1|Halanaerobium hydrogeniformans

100 100

YP 005836365.1|Halanaerobium praevalens DSM 2228 ZP 06969084.1|Ktedonobacter racemifer DSM 44963

100 86

YP 002505817.1|Clostridium cellulolyticum H10 YP 002505891.1|Clostridium cellulolyticum H10 YP 002316720.1|Anoxybacillus flavithermus WK1

66

NP 286669.1|Escherichia coli O157:H7 str. EDL933 YP 003505358.1|Denitrovibrio acetiphilus DSM 12809

100 100

0.1

YP 003503412.1|Denitrovibrio acetiphilus DSM 12809

Figure

A55.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

transposase/integrase containing HTH_28 and rve domains. Bootstrap supports higher than or equal to 60% are shown on the branches. Rpe p12 Rpe1255 Rpe0699 Rpe0357 Rpe0981 Rpe0190

NJ

Rpe0156 Rpe p25 Rpe0557

10084

Rpe1311 Rpe0230 Rpe0266 Rpe0308 Rpe0854 Rpe0970 Rpe1441 Rpe0103 Rpe0116 100

Reis0192 Rfe p65-66

69

Rfe pd32-33 100

RfeI1 p66-67

99

Rma 0650 99

Pla smids a nd chromosome s

Rma 0914 YP 006705243.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

100 100

YP 006705287.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 100

YP 006705697.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 100

YP 006705828.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

YP 001958026.1|Candidatus Amoebophilus asiaticus 5a2 100

YP 001957981.1|Candidatus Amoebophilus asiaticus 5a2 YP 001958043.1|Candidatus Amoebophilus asiaticus 5a2

71 74

Reis1 p44-45

100 98

Rrh0104-05 Reis1 p58-p59

100

Reis3 p43-44 Rra3 p15 trp Rhe0122 Rhe0609

86

100

Rhe1362-64 Rhe1895

ref|NW 001947981.1| Drosophila ananassae strain

99

YP 002726962.1|Wolbachia sp. wRi 100 67

ZP 00373603.1|Wolbachia endosymbiont of Drosophila ananassae YP 002726718.1|Wolbachia sp. wRi ZP 00373085.1|Wolbachia endosymbiont of Drosophila ananassae ref|NW 001951163.1| Drosophila ananassae strain

100

YP 003123181.1|Chitinophaga pinensis DSM 2588

100

YP 004531062.1|Treponema primitia ZAS-2

YP 003125581.1|Chitinophaga pinensis DSM 2588

YP 004531117.1|Treponema primitia ZAS-2 ZP 06089156.1|Bacteroides sp. 3 1 33FAA

100 62

98

ZP 09337756.1|Tannerella sp. 6 1 58FAA CT1 ZP 08475986.1|Dysgonomonas gadei ATCC BAA-286 ZP 10403299.1|Pontibacter sp. BAB1700 YP 004941724.1|Flavobacterium columnare ATCC 49512

63 100

YP 004942782.1|Flavobacterium columnare ATCC 49512

ZP 01689188.1|Microscilla marina ATCC 23134 YP 003122693.1|Chitinophaga pinensis DSM 2588 ZP 09255790.1|Leptospira santarosai str. 2000030832 100

gi|409955218|gb|EKO14158.1|Leptospira kirschneri str. H1 YP 006438211.1|Turneriella parva DSM 21527 100

YP 001603054.1|Gluconacetobacter diazotrophicus PAl 5 YP 001600643.1|Gluconacetobacter diazotrophicus PAl 5

YP 004302435.1|Polymorphum gilvum SL003B-26A1 100

NP 768495.1|Bradyrhizobium japonicum USDA 110 YP 006833063.1|Burkholderia phenoliruptrix BR3459a

100

ZP 02469074.1|Burkholderia thailandensis MSMB43 99

100

ZP 10030508.1|Burkholderia sp. Ch1-1 ZP 10036931.1|Burkholderia sp. Ch1-1

99

YP 001890112.1|Burkholderia phytofirmans PsJN ZP 02885981.1|Burkholderia graminis C4D1M ZP 00134264.2|Actinobacillus pleuropneumoniae str. 4074

100

YP 127369.1|Legionella pneumophila str. Lens

84

YP 006509014.1|Legionella pneumophila subsp. pneumophila

100

YP 006561451.1|Phaeobacter gallaeciensis 2.10 72

67

ZP 09756150.1|Alishewanella jeotgali KCTC 22429 NP 719090.1|Shewanella oneidensis MR-1

100

YP 002986068.1|Dickeya dadantii Ech703 100

0.05

YP 002986544.1|Dickeya dadantii Ech703

76 Rpe p12

Rpe p25

99

Rpe0103 Rpe0116

60

ML

Reis0192 RfeI1 p66-67 9974

Rfe p65-66 100

Rfe pd32-33 98

Rma 0650 90 Rma 0914

100

YP 006705243.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 100

YP 006705697.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

YP 001958026.1|Candidatus Amoebophilus asiaticus 5a2

89

100 97

Rhe0122 Rhe0609

ZP 00373085.1|Wolbachia endosymbiont of Drosophila ananassae Rra3 p15 trp

81 62

Reis3 p43-44

100

Rrh0104-05

99 100

Reis1 p44-45 Reis1 p58-p59

86

YP 006561451.1|Phaeobacter gallaeciensis 2.10

79

YP 006509014.1|Legionella pneumophila subsp. pneumophila ZP 00134264.2|Actinobacillus pleuropneumoniae str. 4074

100

YP 002986068.1|Dickeya dadantii Ech703

63

ZP 09756150.1|Alishewanella jeotgali KCTC 22429

98 72

NP 719090.1|Shewanella oneidensis MR-1

YP 003125581.1|Chitinophaga pinensis DSM 2588 YP 004941724.1|Flavobacterium columnare ATCC 49512 ZP 06089156.1|Bacteroides sp. 3 1 33FAA

100 96

ZP 09337756.1|Tannerella sp. 6 1 58FAA CT1 ZP 08475986.1|Dysgonomonas gadei ATCC BAA-286 ZP 10403299.1|Pontibacter sp. BAB1700 ZP 01689188.1|Microscilla marina ATCC 23134 100

ZP 09255790.1|Leptospira santarosai str. 2000030832 EKO14158.1|Leptospira kirschneri str. H1 YP 006438211.1|Turneriella parva DSM 21527 YP 004531117.1|Treponema primitia ZAS-2 YP 001603054.1|Gluconacetobacter diazotrophicus PAl 5 YP 004302435.1|Polymorphum gilvum SL003B-26A1

100

NP 768495.1|Bradyrhizobium japonicum USDA 110 YP 006833063.1|Burkholderia phenoliruptrix BR3459a 100

0.1

ZP 02469074.1|Burkholderia thailandensis MSMB43

Plasmids and chromosomes

Figure

A56.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

transposase_IS240 /integrase containing rve domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 01550703.1|Stappia aggregata IAM 12614

100

NJ

74

ZP 01550110.1|Stappia aggregata IAM 12614 YP 001373025.1|Ochrobactrum anthropi ATCC 49188

99

ZP 01014510.1|Maritimibacter alkaliphilus HTCC2654 ZP 11157840.1|Nitratireductor indicus C115 ZP 00964727.1|Sulfitobacter sp. NAS-14.1 ZP 01036524.1|Roseovarius sp. 217

96

ZP 01445447.1|Pelagibaca bermudensis HTCC2601 ZP 05051532.1|Octadecabacter antarcticus 307 ZP 05053546.1|Octadecabacter antarcticus 307

100

ZP 05052370.1|Octadecabacter antarcticus 307

59 82

ZP 05053843.1|Octadecabacter antarcticus 307 ZP 06972380.1|Ktedonobacter racemifer DSM 44963

100 100

ZP 06975124.1|Ktedonobacter racemifer DSM 44963 ZP 06972835.1|Ktedonobacter racemifer DSM 44963 ZP 06581673.1|Streptomyces ghanaensis ATCC 14672

100

ZP 10002285.1|Rhodococcus imtechensis

85

YP 708568.1|Rhodococcus jostii

59 100

ZP 10005347.1|Rhodococcus imtechensis

ZP 08778220.1|Candidatus Odyssella thessalonicensis L13

86

ZP 08778278.1|Candidatus Odyssella thessalonicensis L13 Rmo p18 100

Reis4 p160092 99 96

Reis0588 Reis4 p160119

Rra0871

82

Rhe p50-51 89

Rra2 p021-22

60 59

Rra1 p03-05 Rra1103 Rra1 p24-25 Rra11031

0.1

Plasmids and chromosomes

YP 001373025.1|Ochrobactrum anthropi ATCC 49188

95

ZP 01550703.1|Stappia aggregata IAM 12614

ML

ZP 11157840.1|Nitratireductor indicus C115

97 68

ZP 01014510.1|Maritimibacter alkaliphilus HTCC2654 ZP 00964727.1|Sulfitobacter sp. NAS-14.1

73

ZP 01036524.1|Roseovarius sp. 217

93

ZP 01445447.1|Pelagibaca bermudensis HTCC2601 ZP 05053546.1|Octadecabacter antarcticus 307 100

ZP 05051532.1|Octadecabacter antarcticus 307 ZP 06972835.1|Ktedonobacter racemifer DSM 44963 ZP 06581673.1|Streptomyces ghanaensis ATCC 14672

99

ZP 10002285.1|Rhodococcus imtechensis

71

YP 708568.1|Rhodococcus jostii

90 100

ZP 10005347.1|Rhodococcus imtechensis ZP 08778220.1|Candidatus Odyssella thessalonicensis L13

84

ZP 08778278.1|Candidatus Odyssella thessalonicensis L13 Rmo p18 100

Reis4 p160092 100 96

Reis0588 Reis4 p160119

Rhe p50-51

91

Rra1103 82 72

Rra1 p24-25 Rra1 p03-05 Rra0871 Rra2 p021-22 Rra0XXX

0.1

Plasmids and chromosomes

Figure A57. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase mutator family, containing MULE domain. Bootstrap supports higher than or equal to 60% are shown on the branches. ZP 01813361.1|Vibrionales bacterium SW AT-3 65

ZP 01812700.1|Vibrionales bacterium SW AT-3 ZP 01814190.1|Vibrionales bacterium SW AT-3 ZP 01811431.1|Vibrionales bacterium SW AT-3

NJ

ZP 01813563.1|Vibrionales bacterium SW AT-3 86 100

ZP 01812284.1|Vibrionales bacterium SW AT-3 ZP 01811932.1|Vibrionales bacterium SW AT-3 ZP 01811892.1|Vibrionales bacterium SW AT-3

100

ZP 01814993.1|Vibrionales bacterium SW AT-3 ZP 08909480.1|Vibrio rotiferianus DAT722 ZP 06157791.1|Photobacterium damselae subsp. damselae CIP 102761

95

ZP 06157788.1|Photobacterium damselae subsp. damselae CIP 102761

71

ZP 06157355.1|Photobacterium damselae subsp. damselae CIP 102761

100

ZP 06157812.1|Photobacterium damselae subsp. damselae CIP 102761 73 99

60

ZP 06157650.1|Photobacterium damselae subsp. damselae CIP 102761 ZP 06154804.1|Photobacterium damselae subsp. damselae CIP 102761 ZP 06154802.1|Photobacterium damselae subsp. damselae CIP 102761 YP 004312830.1|Marinomonas mediterranea MMB-1 gi|320198397|gb|EFW 72999.1|Escherichia coli EC4100B ZP 08933032.1|Thioalkalimicrobium aerophilum AL3

100

99

ZP 08933606.1|Thioalkalimicrobium aerophilum AL3

ZP 01453599.1|Mariprofundus ferrooxydans PV-1 100

ZP 01451176.1|Mariprofundus ferrooxydans PV-1 ZP 01453437.1|Mariprofundus ferrooxydans PV-1 ZP 09862532.1|Methylomicrobium album BG8

100

ZP 09863445.1|Methylomicrobium album BG8

100

ZP 09862524.1|Methylomicrobium album BG8

69

ZP 09863069.1|Methylomicrobium album BG8 94

ZP 09861908.1|Methylomicrobium album BG8 YP 911676.1|Chlorobium phaeobacteroides DSM 266

96

YP 003526004.1|Nitrosococcus halophilus Nc4 96

YP 003526201.1|Nitrosococcus halophilus Nc4 100

YP 003526514.1|Nitrosococcus halophilus Nc4 YP 003526701.1|Nitrosococcus halophilus Nc4 YP 003525978.1|Nitrosococcus halophilus Nc4

YP 001677230.1|Francisella philomiragia subsp. philomiragia ATCC 25017 YP 006706106.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006706040.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705826.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 100

ref|NC 018605.1 4 Cardinium endosymbiont cPer1 of Encarsia pergandiella

95 92

84

ref|NC 018605.1 6 Cardinium endosymbiont cPer1 of Encarsia pergandiella YP 006706013.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

80

NC 018606.1| Cardinium endosymbiont cPer1 of Encarsia pergandiella ref|NC 018605.1 2 Cardinium endosymbiont cPer1 of Encarsia pergandiella

64 65

ref|NC 018605.1 3 Cardinium endosymbiont cPer1 of Encarsia pergandiella RbeRML1118-19

59

Ram YP 005365433-34 Rpa0879 82

100 99

Rfe p72-73 Rfe pd39-40

RfeI1 p72

100

rpr22 CDS689-91

100

RprME0868-70

100

Rfe1116-17 Rfe0128-29 Rfe0189-90 Rfe1504-03 Rfe1768-69 98

Rfe1456-57 Rfe1530-31 RfeI1 p44-45 Rfe1175-76 Rfe p42-44

80 77

Rfe01342-44 Rfe0118-20 Rfe1369-71 Rfe0495-96 Rfe0756-55 Rfe0393-94 Rfe1181-82 Rfe1188-89 Rfe1274-75

0.05

Pla smids a nd chromosome s

97 Rfe p42-44

Rfe0118-20

ML

98 Rfe0128-29

Rfe0189-90 77

RfeI1 p44-45 rpr22 CDS689-91

100

100 RprME0868-70

Plasmids and chromosomes

RfeI1 p72 100 96

Rfe p72-73

100 Rfe pd39-40

Rpa0879 RbeRML1118-19

94

Ram YP 005365433-34 YP 006706013.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 100

ref|NC 018605.1 2 Cardinium endosymbiont cPer1 of Encarsia pergandiella YP 001677230.1|Francisella philomiragia subsp. philomiragia ATCC 25017 100 YP 003526004.1|Nitrosococcus halophilus Nc4

90

YP 003525978.1|Nitrosococcus halophilus Nc4 YP 911676.1|Chlorobium phaeobacteroides DSM 266 100 ZP 01453437.1|Mariprofundus ferrooxydans PV-1

100

82

ZP 01451176.1|Mariprofundus ferrooxydans PV-1 ZP 09863445.1|Methylomicrobium album BG8 ZP 08933032.1|Thioalkalimicrobium aerophilum AL3

100

EFW72999.1|Escherichia coli EC4100B 75 99

ZP 06157355.1|Photobacterium damselae subsp. damselae CIP 102761 ZP 08909480.1|Vibrio rotiferianus DAT722

100

ZP 01811892.1|Vibrionales bacterium SWAT-3 YP 004312830.1|Marinomonas mediterranea MMB-1

0.1

Figure A58. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase mutator family, containing MULE domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

92 YP 002553575.1|Acidovorax ebreus 98

YP 986889.1|Acidovorax sp. JS42

100

YP 985231.1|Acidovorax sp. JS42 ZP 07044873.1|Comamonas testosteroni S44

97

NJ

YP 001351354.1|Pseudomonas aeruginosa PA7 YP 361525.1|Xanthomonas campestris pv. vesicatoria str. 85-10 92

ZP 10201746.1|Rhodanobacter sp. 116-2

99

YP 004293485.1|Nitrosomonas sp. AL212 ZP 10700819.1|Pseudomonas sp. GM21

87 90

ZP 10255637.1|Burkholderia terrae BS001 YP 004197089.1|Geobacter sp. M18 YP 001229033.1|Geobacter uraniireducens

100 100

YP 001228897.1|Geobacter uraniireducens ZP 10518110.1|Leptospira alexanderi serovar Manhao 3 str. L 60 ZP 09253833.1|Leptospira santarosai str. 2000030832

100 98

ZP 09254882.1|Leptospira santarosai str. 2000030832 YP 911676.1|Chlorobium phaeobacteroides DSM 266 YP 003525978.1|Nitrosococcus halophilus Nc4 100

YP 003526499.1|Nitrosococcus halophilus Nc4

YP 004530681.1|Treponema primitia ZAS-2 99

YP 004698445.1|Spirochaeta caldaria DSM 7334 YP 004526204.1|Treponema azotonutricium ZAS-9

100

YP 004525649.1|Treponema azotonutricium ZAS-9

100 100

YP 004529005.1|Treponema azotonutricium ZAS-9

ZP 06156186.1|Photobacterium damselae subsp. damselae CIP 102761 ZP 04510766.1|Yersinia pestis Pestoides A 100

NP 995198.1|Yersinia pestis biovar Microtus str. 91001 100 65

NP 395426.1|Yersinia pestis CO92 YP 001871174.1|Yersinia pseudotuberculosis PB1/+ YP 636759.1|Yersinia pestis Antiqua NP 669353.1|Yersinia pestis KIM10+

100

Ram23 p17-20 Ram YP 005365631

Plasmids and chromosomes

NW 002061028.1| Trichoplax adhaerens strain Grell-B S-1999 TRIAD Reis2 p86-87 Reis0187-89 Reis0692-93 Reis1285-86 Reis2 p05-06 Reis2215-16 100

Reis1226-27 Reis0898-99 Reis0851-52 Reis0797-78 Reis0518-19 Reis1030-31 Reis2 p53-54 Reis0392-93

63

Reis0564-65 Reis1076-77 Reis0375-76 Reis4 p160079

0.1

Plasmids and chromosomes

99

ZP 07044873.1|Comamonas testosteroni S44 YP 002553575.1|Acidovorax ebreus

75

ML

YP 001351354.1|Pseudomonas aeruginosa PA7 YP 361525.1|Xanthomonas campestris pv. vesicatoria str. 85-10 ZP 10201746.1|Rhodanobacter sp. 116-2

100

ZP 10255637.1|Burkholderia terrae BS001 83

YP 004293485.1|Nitrosomonas sp. AL212 YP 001229033.1|Geobacter uraniireducens ZP 09253833.1|Leptospira santarosai str. 2000030832 YP 003525978.1|Nitrosococcus halophilus Nc4

60

YP 911676.1|Chlorobium phaeobacteroides DSM 266 YP 004698445.1|Spirochaeta caldaria DSM 7334 99

YP 004526204.1|Treponema azotonutricium ZAS-9 ZP 06156186.1|Photobacterium damselae subsp. damselae CIP 102761 100 100

YP 001871174.1|Yersinia pseudotuberculosis PB1/+ Ram23 p17-20

62

Ram YP 005365631 NW 002061028.1| Trichoplax adhaerens strain Grell-B S-1999 TRIAD Reis2 p86-87 Reis0170-71 Reis2 p53-54 89

Reis2 p05-06 Reis4 p160138 Reis0038-41 Reis4 p160079

0.1

Plasmids and chromosomes

Figure A59. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing HTH_28 and DDE_3 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

OtsIk1831-32 OtsIk2086-87 OtsIk2309-10

NJ

OtsIk2416-17 OtsIk1207-08 OtsIk1453-54 OtsIk0937-38 OtsIk1157-58 OtsIk0774-75 OtsIk0861-62 OtsIk0678-79

100

OtsIk2476-77 OtsIk2597-98 OtsIk0676-77 OtsIk0863-64

75

OtsIk1155-56 99

OtsIk1205-06 OtsIk1451-52 Rfe0483-84 Rfe p83

99 100

Plasmids and chromosomes

Rfe pd50 RfeI1 p85

Reis2196 Reis2 p11 Reis0194 Reis0244 Reis0433 100

Reis0699 Reis0834 Reis1087 Reis1141 Reis1468

68

Reis1258 Reis1640 Reis1940 Reis2131 Reis2234 Reis2339 Reis0511 Reis1347

63

Reis1393 ZP 03271775.1|Arthrospira maxima CS-328 gi|406715588|gb|EKD10742.1|Arthrospira platensis C1

100

gi|406713153|gb|EKD08327.1|Arthrospira platensis C1 ZP 03273272.1|Arthrospira maxima CS-328 82 81

0.1

ZP 03275742.1|Arthrospira maxima CS-328 gi|406716360|gb|EKD11511.1|Arthrospira platensis C1

OtsIk0937-38

ML

OtsIk1157-58 100

OtsIk0861-62 OtsIk0678-79

70

OtsIk0774-75 Rfe0483-84 Rfe pd50 99

Plasmids and chromosomes

Rfe p83 100

RfeI1 p85 Reis0244 Reis2 p11 Reis0194 100 Reis0433

Reis0699 Reis0834 ZP 03271775.1|Arthrospira maxima CS-328 100

gi|406715588|gb|EKD10742.1|Arthrospira platensis C1 gi|406713153|gb|EKD08327.1|Arthrospira platensis C1

61

0.1

ZP 03273272.1|Arthrospira maxima CS-328

Figure A60. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase IS200 familiy protein containing Y1 domain. Bootstrap supports higher than or equal to 60% are shown on the branches. Reis4 p160013 Reis0573 Reis4 p160076 99

Reis4 p160104 Reis4 p160131

NJ

Reis0371 Reis2 p29 Reis2 p41

64

Reis1 p54 Reis0389 Reis0403

93

Pla smids a nd chromosome s

Reis0432 Reis0523 Rau0093 Rau0106 Rau0252

98

Rau0030

96

Rau0077

80 92

RakNC 009881.1 4

69

RakNC 009881.1 5 100

100

Rak NC 009881.1 1 RakNC 009881.1 2

66

RakNC 009881.1 3 ref|NC 015713.1| Simkania negevensis Z gi|124514250|gb|EAY55764.1|Leptospirillum rubarum

65 100

gi|251773455|gb|EES54003.1|Leptospirillum ferrodiazotrophum

YP 004471499.1|Thermoanaerobacterium xylanolyticum LX-11 69

YP 004471575.1|Thermoanaerobacterium xylanolyticum LX-11

100

YP 004469863.1|Thermoanaerobacterium xylanolyticum LX-11 YP 006393000.1|Thermoanaerobacterium saccharolyticum JW /SL-YS485

92

NP 116806.1|Microscilla sp. PRE1 68

ZP 01092534.1|Blastopirellula marina DSM 3645 99

ZP 11091237.1|Schlesneria paludicola DSM 18645 79

YP 004168103.1|Nitratifractor salsuginis DSM 16511 YP 004167850.1|Nitratifractor salsuginis DSM 16511

100

YP 004168267.1|Nitratifractor salsuginis DSM 16511 ZP 03788014.1|W olbachia endosymbiont of Muscidifurax uniraptor

100

ZP 03787974.1|W olbachia endosymbiont of Muscidifurax uniraptor ZP 03787863.1|W olbachia endosymbiont of Muscidifurax uniraptor 80

Rma 0649 Rma 0559 Rma 0907

82

83

Rma 0549

100

Rma 0395

92

Rra0744 Reis1 p56 Rca0781-782

99

Rca0317-18

98 90

Rca0581-82

62 60 100

Pla smids a ns chromosome s

Rca0598

67

ZP 10341737.1|Sphingomonas echinoides ATCC 14820 ZP 09194842.1|Novosphingobium pentaromativorans US6-1

85

ZP 09910213.1|Sphingobium yanoikuyae XLDN2-5 ZP 09191312.1|Novosphingobium pentaromativorans US6-1 YP 916856.1|Paracoccus denitrificans PD1222

100

60

ZP 01904543.1|Roseobacter sp. AzwK-3b ZP 05052080.1|Octadecabacter antarcticus 307

73

ZP 05125104.1|Rhodobacteraceae bacterium KLH11 92

ZP 05062886.1|Octadecabacter arcticus 238 ZP 01038074.1|Roseovarius sp. 217

81

YP 003190033.1|Desulfotomaculum acetoxidans DSM 771 ZP 09654130.1|Desulfosporosinus youngiae DSM 17734 100

YP 131678.1|Photobacterium profundum SS9 YP 130063.1|Photobacterium profundum SS9

78

YP 003704612.1|Truepera radiovictrix DSM 17093 100

YP 003704860.1|Truepera radiovictrix DSM 17093

100

YP 003704222.1|Truepera radiovictrix DSM 17093 NP 929132.1|Photorhabdus luminescens subsp. laumondii 100

77

NP 930380.1|Photorhabdus luminescens subsp. laumondii NP 928646.1|Photorhabdus luminescens subsp. laumondii

89 70

ZP 10760977.1|Pseudomonas pseudoalcaligenes CECT 5344 ZP 10762487.1|Pseudomonas pseudoalcaligenes CECT 5344 YP 004294897.1|Nitrosomonas sp. AL212 ZP 09863374.1|Methylomicrobium album BG8 ZP 08825639.1|Thiorhodococcus drewsii AZ1

95 99 97

0.1

ZP 08825244.1|Thiorhodococcus drewsii AZ1 ZP 08825480.1|Thiorhodococcus drewsii AZ1

Reis0389

ML

Reis0403 Reis0371 Reis4 p160131 Reis4 p160104 98

Reis4 p160076 Reis2 p41 Reis1 p54 Reis2 p29

81

Plasmids and chromosomes

Reis0432 Reis4 p160013 100 Rak NC 009881.1 1

Rak NC 009881.1 2

80

Rau0093

88 98

100

Rau0030

83 Rau0077

ref|NC 015713.1| Simkania negevensis Z gi|124514250|gb|EAY55764.1|Leptospirillum rubarum

66

NP 116806.1|Microscilla sp. PRE1 YP 004469863.1|Thermoanaerobacterium xylanolyticum LX-11 ZP 01092534.1|Blastopirellula marina DSM 3645 92

ZP 11091237.1|Schlesneria paludicola DSM 18645 YP 004168267.1|Nitratifractor salsuginis DSM 16511

78

YP 003190033.1|Desulfotomaculum acetoxidans DSM 771 ZP 09654130.1|Desulfosporosinus youngiae DSM 17734 ZP 10760977.1|Pseudomonas pseudoalcaligenes CECT 5344 NP 929132.1|Photorhabdus luminescens subsp. laumondii YP 004294897.1|Nitrosomonas sp. AL212 YP 003704222.1|Truepera radiovictrix DSM 17093

73

ZP 08825639.1|Thiorhodococcus drewsii AZ1

99 75

ZP 09863374.1|Methylomicrobium album BG8 YP 131678.1|Photobacterium profundum SS9 95

ZP 10341737.1|Sphingomonas echinoides ATCC 14820 ZP 09910213.1|Sphingobium yanoikuyae XLDN2-5 YP 916856.1|Paracoccus denitrificans PD1222

78

100

ZP 01904543.1|Roseobacter sp. AzwK-3b ZP 05052080.1|Octadecabacter antarcticus 307 ZP 05062886.1|Octadecabacter arcticus 238

82

ZP 01038074.1|Roseovarius sp. 217 98

100 99

Rca0598 Rca0581-82

Reis1 p56 ZP 03788014.1|Wolbachia endosymbiont of Muscidifurax uniraptor

97

Rra0744

82 97

Rma 0395

93 Rma 0549

0.2

Plasmids and chromosomes

Figure A61. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase DDE_Tnp_1 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

99

Reis2 p31-32 Reis1294-95

Reis2122-23 Reis1328-30 Reis1177-78 Reis1129-30 Reis1078-79

NJ

Reis0838-39 Reis0217-18 Reis038-39 Reis0355-56 Reis0420-21 Reis0487-88

Plasmids and chromosomes

Reis0508-09 Reis2186-87 66

Reis0034-35 Reis0328-81 Reis0672-73

99

Reis0632-33 Reis0716-17

97

Reis2325-26 Reis2384-85 Reis2129-30

99

Reis2 p90-92 Reis1 p40-43 YP 006411578.1|Alistipes finegoldii DSM 17242

99

ZP 10369300.1|Bacteroides salyersiae CL02T12C01 99

99

YP 006869122.1|Psychroflexus YP 006867218.1|Psychroflexus ZP 09523001.1|Myroides odoratimimus CCUG 10230

83 99

ZP 09523542.1|Myroides odoratimimus CCUG 10230 ZP 09524278.1|Myroides odoratimimus CCUG 10230 ZP 08431897.1|Moorea producens 3L

99 82

YP 001736121.1|Synechococcus sp. PCC 7002 YP 003506243.1|Meiothermus ruber DSM 1279 ZP 08462233.1|Psychrobacter sp. 1501(2011)

90

ZP 09622591.1|Legionella drancourtii LLAP12

91

ZP 09863071.1|Methylomicrobium album BG8 YP 006505632.1|Legionella pneumophila subsp. pneumophila

69 99 92

YP 094854.1|Legionella pneumophila str. Philadelphia 1 YP 123054.1|Legionella pneumophila str. Paris YP 123209.1|Legionella pneumophila str. Paris

0.2

100 YP 123209.1|Legionella pneumophila str. Paris

ML

YP 006505632.1|Legionella pneumophila subsp. pneumophila 71

ZP 09622591.1|Legionella drancourtii LLAP12

87

ZP 09863071.1|Methylomicrobium album BG8 ZP 08462233.1|Psychrobacter sp. 1501(2011)

68

YP 003506243.1|Meiothermus ruber DSM 1279 ZP 08431897.1|Moorea producens 3L

91 100 80

YP 001736121.1|Synechococcus sp. PCC 7002 YP 006869122.1|Psychroflexus ZP 09523001.1|Myroides odoratimimus CCUG 10230 100 ZP 09523542.1|Myroides odoratimimus CCUG 10230

100

ZP 10369300.1|Bacteroides salyersiae CL02T12C01 100

YP 006411578.1|Alistipes finegoldii DSM 17242 Reis1 p40-43 Reis2 p90-92 100

Reis0217-18 94

Reis038-39 Reis2 p31-32 Reis0034-35

68 Reis0328-81

0.2

Plasmids and chromosomes

Figure A62. Neighbor-joining (NJ) and maximum likelihood (ML) trees of RNA-directed DNA polymerases. Bootstrap supports higher than or equal to 60% are shown on the branches.

100

NJ

NP 619481.1|Methanosarcina acetivorans C2A

100 64

NP 617694.1|Methanosarcina acetivorans C2A YP 003193327.1|Desulfotomaculum acetoxidans DSM 771 YP 004720173.1|Sulfobacillus acidophilus

68

YP 003428936.1|Bacillus pseudofirmus OF4 97

96

ZP 09207315.1|Clostridium sp. DL-VIII ZP 08778662.1|Candidatus Odyssella thessalonicensis L13 YP 911931.1|Chlorobium phaeobacteroides DSM 266

67

YP 001129678.1|Chlorobium phaeovibrioides DSM 265

100 100

YP 002016759.1|Prosthecochloris aestuarii DSM 271 YP 918298.1|Paracoccus denitrificans PD1222

98 99

ZP 10178025.1|Microvirga sp. WSM3557 YP 002541754.1|Agrobacterium radiobacter K84 ZP 10169695.1|Desulfobacter postgatei 2ac9

99

YP 002015331.1|Prosthecochloris aestuarii DSM 271

75

NP 928428.1|Photorhabdus luminescens subsp. laumondii

99 100 97

YP 003712053.1|Xenorhabdus nematophila ATCC 19061

ZP 09568983.1|Singulisphaera acidiphila DSM 18658 ZP 09577626.1|Holophaga foetida DSM 6591 ZP 09165954.1|Frankia sp. CN3 YP 864580.1|Magnetococcus marinus MC-1

72

YP 001974985.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel Reis2 p70 Reis0377 100

Reis0463

0.05

Plasmids and chromosomes

Reis2 p70

ML

100

Reis0463

Plasmids and chromosomes

Reis0377 YP 001974985.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel ZP 09165954.1|Frankia sp. CN3 YP 864580.1|Magnetococcus marinus MC-1 ZP 09568983.1|Singulisphaera acidiphila DSM 18658 97

ZP 09577626.1|Holophaga foetida DSM 6591 100 NP 928428.1|Photorhabdus luminescens subsp. laumondii

100

YP 003712053.1|Xenorhabdus nematophila ATCC 19061 YP 002015331.1|Prosthecochloris aestuarii DSM 271

97

YP 002541754.1|Agrobacterium radiobacter K84 YP 918298.1|Paracoccus denitrificans PD1222

98 98

ZP 10178025.1|Microvirga sp. WSM3557 100

77

YP 001129678.1|Chlorobium phaeovibrioides DSM 265 YP 002016759.1|Prosthecochloris aestuarii DSM 271 ZP 08778662.1|Candidatus Odyssella thessalonicensis L13

YP 004720173.1|Sulfobacillus acidophilus

99

YP 003428936.1|Bacillus pseudofirmus OF4 YP 003193327.1|Desulfotomaculum acetoxidans DSM 771

63 62

0.1

NP 619481.1|Methanosarcina acetivorans C2A

Figure A63. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Reis2 p71 99

Reis ZP 04698294

Plasmids and chromosomes

Reis ZP 04698666 NW 002145881.1|Hydra magnipapillata YP 003193328.1|Desulfotomaculum acetoxidans DSM 771

0.1

ML

Reis ZP 04698294 100

Reis ZP 04698666

Plasmids and chromosomes

Reis2 p71 NW 002145881.1|Hydra magnipapillata YP 003193328.1|Desulfotomaculum acetoxidans DSM 771

0.05

Figure A64. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

99 67

NJ

EHS52844.1| Rhizobium sp. PDO1-076 EGP55074.1| Agrobacterium tumefaciens F2 EIJ75085.1|Leptospirillum sp. Group II C75

64

YP 986457.1| Acidovorax sp. JS42 69

YP 004664861.1| Myxococcus fulvus HW-1

81 55

YP 003744192.1|Ralstonia solanacearum CFBP2957 ref|NZ CM000756.1| Bacillus thuringiensis

gZP 09702887.1|Methanoplanus limicola DSM 2279 Reis3 p22 100

0.1

Reis1516

Plasmids and chromosomes

ML

97

EHS52844.1| Rhizobium sp. PDO1-076 EGP55074.1| Agrobacterium tumefaciens F2 EIJ75085.1|Leptospirillum sp. Group II C75 YP 986457.1| Acidovorax sp. JS42

65

YP 004664861.1| Myxococcus fulvus HW-1

77 76

YP 003744192.1|Ralstonia solanacearum CFBP2957

ref|NZ CM000756.1| Bacillus thuringiensis gZP 09702887.1|Methanoplanus limicola DSM 2279 Reis3 p22 100

0.2

Reis1516

Plasmids and chromosomes

Figure A65. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing HTH_1 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

ZP 05040611.1|Alcanivorax sp. DG881

100

YP 693802.1|Alcanivorax borkumensis SK2

78

ZP 01101557.1|Congregibacter litoralis KT71 100 ZP 01104197.1|Congregibacter litoralis KT71 92

YP 001458750.1|Escherichia coli HS ZP 01988947.1|Vibrio parahaemolyticus AQ3810 100

YP 001472385.1|Shewanella sediminis HAW-EB3 YP 002309585.1|Shewanella piezotolerans WP3

YP 001140018.1|Aeromonas salmonicida subsp. salmonicida A449 100

YP 001142595.1|Aeromonas salmonicida subsp. salmonicida A449

YP 587584.1|Cupriavidus metallidurans CH34

96

YP 001765073.1|Burkholderia cenocepacia MC0-3 YP 001971495.1|Stenotrophomonas maltophilia K279a

90

ZP 10263651.1|Xanthomonas axonopodis pv. punicae str. LMG 859

66 100

NP 638055.1|Xanthomonas campestris pv. campestris str. ATCC 33913 ZP 07674353.1|Ralstonia sp. 5 7 47FAA

YP 003006527.1|Dickeya zeae Ech1591 99

YP 003051239.1|Methylovorus glucosetrophus SIP3-4

ZP 08960189.1|Halomonas sp. HAL1

96

ZP 09186649.1|Halomonas boliviensis LC1 YP 609434.1|Pseudomonas entomophila L48 YP 006457142.1|Pseudomonas stutzeri CCUG 29243

97

ZP 10440772.1|Pseudomonas extremaustralis 14-3 substr. 14-3b 100 YP 272176.1|Pseudomonas syringae pv. phaseolicola 1448A

99

YP 001476624.1|Serratia proteamaculans 568 100

ZP 04618004.1|Yersinia ruckeri ATCC 29473 YP 001415476.1|Xanthobacter autotrophicus Py2 ZP 11268558.1|Rhizobium mesoamericanum STM3625

98 81

YP 004302255.1|Polymorphum gilvum SL003B-26A1 100 ZP 06965012.1|Ktedonobacter racemifer DSM 44963

ZP 06965038.1|Ktedonobacter racemifer DSM 44963 97 Rpe p21

Rma 0910

Plasmids and chromosomes

ZP 09862549.1|Methylomicrobium album BG8

90

YP 003526170.1|Nitrosococcus halophilus Nc4

86

YP 004294083.1|Nitrosomonas sp. AL212 81

ZP 08782724.1|Methylobacter tundripaludum SV96 98 ZP 08779561.1|Methylobacter tundripaludum SV96

0.1

98

ML

ZP 05040611.1|Alcanivorax sp. DG881 YP 693802.1|Alcanivorax borkumensis SK2 ZP 01101557.1|Congregibacter litoralis KT71 99 ZP 01104197.1|Congregibacter litoralis KT71

77

YP 001458750.1|Escherichia coli HS ZP 01988947.1|Vibrio parahaemolyticus AQ3810 YP 001472385.1|Shewanella sediminis HAW-EB3 YP 001140018.1|Aeromonas salmonicida subsp. salmonicida A449 59

ZP 10263651.1|Xanthomonas axonopodis pv. punicae str. LMG 859 YP 001971495.1|Stenotrophomonas maltophilia K279a

68

YP 587584.1|Cupriavidus metallidurans CH34 65

95

YP 001765073.1|Burkholderia cenocepacia MC0-3

YP 003006527.1|Dickeya zeae Ech1591 YP 003051239.1|Methylovorus glucosetrophus SIP3-4 ZP 07674353.1|Ralstonia sp. 5 7 47FAA

100

ZP 08960189.1|Halomonas sp. HAL1 YP 001476624.1|Serratia proteamaculans 568 ZP 10440772.1|Pseudomonas extremaustralis 14-3 substr. 14-3b 96

YP 006457142.1|Pseudomonas stutzeri CCUG 29243 ZP 11268558.1|Rhizobium mesoamericanum STM3625 100

YP 004302255.1|Polymorphum gilvum SL003B-26A1

ZP 06965012.1|Ktedonobacter racemifer DSM 44963 90

Rpe p21 Rma 0910

Plasmids and chromosomes YP 003526170.1|Nitrosococcus halophilus Nc4

59

ZP 09862549.1|Methylomicrobium album BG8 ZP 08782724.1|Methylobacter tundripaludum SV96 60

0.2

YP 004294083.1|Nitrosomonas sp. AL212

Figure A66. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing DDE_Tnp_1_3 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ ZP 09864006.1|Methylomicrobium album BG8

100 99

NP 841771.1|Nitrosomonas europaea ATCC 19718 YP 984307.1|Polaromonas naphthalenivorans CJ2

93

ZP 08461095.1|Psychrobacter sp. 1501(2011) YP 001279606.1|Psychrobacter sp. PRwf-1

100 70

gi|28611027|emb|CAD32236.1|Moraxella sp. O245

ZP 10103782.1|Thiothrix nivea DSM 5205 gi|389880865|emb|CCI38498.1|Microcystis aeruginosa PCC 9701 100

gi|389675913|emb|CCH95004.1|Microcystis aeruginosa PCC 9432

YP 003467750.1|Xenorhabdus bovienii SS-2004

98 72

YP 002262862.1|Aliivibrio salmonicida LFI1238 62

YP 006295492.1|Methylophaga sp. JAM1 100 YP 006297215.1|Methylophaga sp. JAM1

99

gi|307609561|emb|CBW99061.1|Legionella pneumophila 130b ZP 06742003.1|Bacteroides vulgatus PC510 YP 005824514.1|Francisella cf. novicida 3523 100

Rmo p10-Rmo p11 Rak0657

OtsIk0268 66 100

OtsIk0539 OtsIk2708 OtsIk0725

73

0.1

OtsIk0826

Plasmids and chromosomes

ZP 09864006.1|Methylomicrobium album BG8

100 95

NJ

NP 841771.1|Nitrosomonas europaea ATCC 19718 YP 984307.1|Polaromonas naphthalenivorans CJ2

91

YP 001279606.1|Psychrobacter sp. PRwf-1 100

gi|28611027|emb|CAD32236.1|Moraxella sp. O245 YP 006295492.1|Methylophaga sp. JAM1 YP 003467750.1|Xenorhabdus bovienii SS-2004

76 85

YP 002262862.1|Aliivibrio salmonicida LFI1238 CCH95004.1|Microcystis aeruginosa PCC 9432 ZP 10103782.1|Thiothrix nivea DSM 5205 YP 005824514.1|Francisella cf. novicida 3523

94

CBW99061.1|Legionella pneumophila 130b ZP 06742003.1|Bacteroides vulgatus PC510 100

Rmo p10-Rmo p11 Rak0657

OtsIk0268 100

0.2

OtsIk0539

Plasmids and chromosomes

Figure A67. Neighbor-joining (NJ) and maximum likelihood (ML) trees of guanosine polyphosphate pyrophosphohydrolase/synthetase SpoT23. Bootstrap supports higher than or equal to 60% are shown on the branches. OtsBo1344

79

OtsBo2044 OtsBo2218 95

OtsBo0123

NJ

OtsBo2419 OtsBo2299 OtsBo2671 OtsBo1117

98

87

OtsBo1647

77

OtsBo2870

72

OtsBo1152 100

OtsBo2717

59 98 99

OtsBo1512 OtsBo2761 OtsBo0055

Rhe1000 89

Rpa0874

88 100

Reis1757 Rma 0921

Pla smids a nd chromosome s

Reis1800

80

Rra0758

96

Ram YP 005365640

100

RbeRML0504 Rmo850173 Rph0867

100

Reis0954 Reis3 p17 Reis1668 Rmo p22 Ram_YP 005365659 100

Reis0591 Reis4_p160122

81

Rra0887 Rra3 p17 100

Rca0658 Rca4100567 Rfe0485

98 82 87

Ram_YP 005365642 Rra0755 RbeRML0673 RprME0755

81 60

Rty0790

100

Rma 1245 Rau0673

83

Rfe1219

100

Rhe0811 Rfe0561 Rfe0576 Rfe1123 97

Rel1335 Rca0545 100

Rca4100475 RbeRML0690 RbeRML1261

RbeRML0984 69

Rca0996 rpr22 CDS306

95

Rty0388

100

Rak0559 Reis1174 Rau1300 Rfe0645 Rra0562

65

Ram_YP 005365177 Rma 0531 81 91

Raf0577 RriBr0977

59 Rpa0518 69

Rpe1056 YP 002480116.1|Desulfovibrio desulfuricans YP 002543916.1|Agrobacterium radiobacter K84

100

YP 004088754.1|Asticcacaulis excentricus CB 48

60 99

0.2

ZP 08268428.1|Brevundimonas diminuta ATCC 11568

Raf0577 Rpe1056

93

Rpa0518 RriBr0977

89

Rma 0531 Rra0562

23 68

YP 005365177.1|Candidatus

ML

Rfe0645 Reis1174

48

Rak0559 Rau1300

99

rpr22 CDS306 Rty0388

93 22

Rca0996 Rfe0576

45

RbeRML0984

59

Rfe1219

30

Rhe0811

98 90

Rca0545 100

Rca4100475 RprME0755

51

Rty0790

100

Rra3 p17 Reis0591

100 62

Plasmids and chromosomes

Reis160122 Rra0887

30

Rmo p22

65 35

Ram_YP 005365659 Rca0658

28

Rfe0485

86 85

Ram_YP 005365642

70

Rra0755

Reis1668 Reis3 p17 99

OtsBo1117 OtsBo1647

100 49

OtsBo1344 100

OtsBo2044

Rhe1000

83

Rpa0874

96 95

Reis1757

36

Rma 0921 Reis1800

66

Rra0758

73

Ram YP 005365640

94

RbeRML0504 51

Rmo850173 99

Rph0867 Reis0954

YP 002543916.1|Agrobacterium radiobacter K84

0.2

Figure A68. Neighbor-joining (NJ) and maximum likelihood (ML) trees of hemK gene. Bootstrap supports higher than or equal to 60% are shown on the branches.

78

Rmo p24 Ram YP 005365661

Plasmids and chromosomes

OtsIk2076 YP 004484898.1| methylase Methanotorris igneus Kol 5

0.1

72

ML

Rmo p24 Ram YP 005365661

Plasmids and chromosomes

OtsIk2076 YP 004484898.1| methylase Methanotorris igneus Kol 5

0.1

Figure

A69.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

deoxyribodipyrimidine photo-lyase. Bootstrap supports higher than or equal to 60% are shown on the branches.

100

NJ

100

RbeOSU1655 RbeRML0123

Plasmids and chromosomes

Ram23 p14

100

OtsIk2194 100

OtsBo0019-23

YP 004052179.1| Marivirga tractuosa DSM 4126 ZP 004388865.1| Alicycliphilus denitrificans K601 EJC62183.1| Alcaligenes faecalis subsp. faecalis NCIB 8687

99 76

0.1

ZP 08885514.1| Neisseria shayeganii 871

96 RbeOSU1655

ML

RbeRML0123 100

Plasmids and chromosomes

Ram23 p14 OtsIk2194 100

OtsBo0019-23

YP 004052179.1| Marivirga tractuosa DSM 4126 ZP 004388865.1| Alicycliphilus denitrificans K601 100 88

0.2

EJC62183.1| Alcaligenes faecalis subsp. faecalis NCIB 8687 ZP 08885514.1| Neisseria shayeganii 871

Figure A70. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NP 635003.1|Methanosarcina mazei Go1

NJ

YP 004315417.1|Sphingobacterium sp. 21 ZP 08960777.1|Halomonas sp. HAL1 YP 504201.1| Methanospirillum hungatei JF-1 YP 003087225.1| Dyadobacter fermentans DSM 18053 86

YP 002015011.1| Prosthecochloris aestuarii DSM 271 ZP 09240774.1| Pseudoalteromonas sp. BSi20480 ZP 03335668.1| Wolbachia endosymbiont of Culex quinquefasciatus JHB 100

YP 001976026.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel ZP 09658079.1| Leptonema illini DSM 21528 Ram18 p24

100

0.1

Rfe1062

Plasmids and chromosomes

NP 635003.1|Methanosarcina mazei Go1 YP 004315417.1|Sphingobacterium sp. 21

ML

YP 504201.1| Methanospirillum hungatei JF-1 YP 003087225.1| Dyadobacter fermentans DSM 18053 ZP 08960777.1|Halomonas sp. HAL1 67

YP 002015011.1| Prosthecochloris aestuarii DSM 271 ZP 09240774.1| Pseudoalteromonas sp. BSi20480 ZP 09658079.1| Leptonema illini DSM 21528 ZP 03335668.1| Wolbachia endosymbiont of Culex quinquefasciatus JHB 100 YP 001976026.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

Ram18 p24 100

Rfe1062

Plasmids and chromosomes

0.2

Figure A71. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Rfe p89 Rfe pd56

Plasmids

RfeI1 p91 Ram NC 017028.1|

Chromosomes

0.05

ML

Rfe pd56 RfeI1 p91

Plasmids

Rfe p89 Ram NC 017028.1|

0.05

Chromosomes

Figure A72. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

100 ZP 05879254.1|Vibrio furnissii CIP 102972

NJ

100

YP 005048623.1|Vibrio furnissii NCTC 11218 YP 943853.1|Psychromonas ingrahamii 37 YP 004010233.1|Acinetobacter phage Acj9 YP 001323089.1|Methanococcus vannielii SB YP 004743024.1|Methanococcus maripaludis X1

100 99

YP 001549462.1|Methanococcus maripaludis C6

YP 003827802.1|Acetohalobium arabaticum DSM 5501 YP 239315.1|Xanthomonas phage Xp15 YP 422991.1|Magnetospirillum magneticum AMB-1

65 100 100

ZP 00053971.1|Magnetospirillum magnetotacticum MS-1

OtsBo2449 OtsIk1669 ZP 09542207.1|Wolbachia pipientis wAlbB

100 100

ZP 00374023.1|Wolbachia endosymbiont of Drosophila ananassae NP 966394.1|Wolbachia endosymbiont of Drosophila melanogaster Rra1 p01

100

Reis1787

Plasmids and chromosmes

YP 004508667.1|Synechococcus phage S-CRM01 YP 004323290.1|Prochlorococcus phage P-RSM4

100 99

0.1

ML

YP 214688.1|Prochlorococcus phage P-SSM4

87

ZP 00374023.1|Wolbachia endosymbiont of Drosophila ananassae

83 95

NP 966394.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 09542207.1|Wolbachia pipientis wAlbB OtsBo2449 100

OtsIk1669 YP 004508667.1|Synechococcus phage S-CRM01 YP 004323290.1|Prochlorococcus phage P-RSM4

100 95

YP 214688.1|Prochlorococcus phage P-SSM4

YP 239315.1|Xanthomonas phage Xp15 Rra1 p01 100

Reis1787

Plasmids and chromosomes

YP 004743024.1|Methanococcus maripaludis X1

71 100

YP 001549462.1|Methanococcus maripaludis C6 YP 001323089.1|Methanococcus vannielii SB 100

YP 422991.1|Magnetospirillum magneticum AMB-1 ZP 00053971.1|Magnetospirillum magnetotacticum MS-1 YP 004010233.1|Acinetobacter phage Acj9

YP 003827802.1|Acetohalobium arabaticum DSM 5501 YP 943853.1|Psychromonas ingrahamii 37 100

ZP 05879254.1|Vibrio furnissii CIP 102972 100 YP 005048623.1|Vibrio furnissii NCTC 11218

0.2

Figure A73. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

Rco 233

NJ

Rsi246 0644 49

Raf0276 Rpa0252 Rsim C270180

99

Rpe0282 Rph0249 RriBr1251 89 58 RriIo0289 70

RriSh0285 Rel0260 95 92

Rja0256

54 Rmo851154

Plasmids and chromosomes

55 Rra0277

Ram YP 005364976

50 90

100

98

Rrh0369 RmaB0272

61 Rma 0258

Rhe1772 100

Rfe1427 59

67

Rau1568 Rty0188

Reis2 p08 Ram YP 005364832

100 100 RbeOSU0971

RbeRML0791

Chromosmes

OtsBo0402 100

0.1

OtsIk1579

Rco 233 Rsi246 0644 Rpa0252 Rsim C270180

ML

Raf0276

97

Rpe0282 Rph0249 RriBr1251 92 70 RriIo0289 64

RriSh0285 Rel0260

94 92 Rja0256

Plasmids and chromosomes

Rmo851154 Ram YP 005364976 67

Rra0277 Rrh0369

96

RmaB0272

98 68 Rma 0258

Rfe1427 91

73

Rau1568 Rhe1772 Rty0188 Reis2 p08 Ram YP 005364832

100 100 RbeOSU0971

RbeRML0791 OtsBo0402 100

0.2

OtsIk1579

Chromosomes

Figure A74. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase_20 IS116/IS110/IS902 family protein containing DEDD_IS110 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

CBA32588.1|Curvibacter putative symbiont of Hydra magnipapillata

99 92

NJ

YP 982698.1|Polaromonas naphthalenivorans CJ2 YP 973384.1|Polaromonas naphthalenivorans CJ2

98

ZP 10156634.1|Hydrogenophaga sp. PBC 100

YP 999248.1|Verminephrobacter eiseniae EF01-2 YP 004785026.1|Acidithiobacillus ferrivorans SS3 100

YP 004784773.1|Acidithiobacillus ferrivorans SS3

92 YP 004784777.1|Acidithiobacillus ferrivorans SS3

ZP 02367662.1|Burkholderia oklahomensis C6786 YP 003846766.1|Gallionella capsiferriformans ES-2

100

YP 004693596.1|Nitrosomonas sp. Is79A3 71

YP 973618.1|Polaromonas naphthalenivorans CJ2

75

gi|356685786|gb|EHI50407.1|Aeromonas salmonicida subsp. salmonicida 01-B526

85 99

68

YP 004392732.1|Aeromonas veronii B565 YP 002233619.1|Burkholderia cenocepacia J2315 ZP 10023820.1|Burkholderia sp. SJ98 YP 003461264.1|Thioalkalivibrio sp. K90mix 100 YP 004249870.1|Klebsiella pneumoniae

ZP 07133366.1|Escherichia coli MS 115-1 ZP 10892581.1|Klebsiella sp. OBRC7

100

99

YP 002932350.1|Edwardsiella ictaluri 93-146

99

100 YP 002932960.1|Edwardsiella ictaluri 93-146 88 YP 002933640.1|Edwardsiella ictaluri 93-146

ZP 06157762.1|Photobacterium damselae subsp. damselae CIP 102761 Rhe0809

100

Rhe1806 Rfe pd43-44 100

RfeI1 p75-77

100

Rfe p76-77 Rma 0296-97 99

Plasmids and chromosomes

Rma 0518-19 Rma 1062-63 100

Rma 1249-50 Rma 1627-28 ZP 01305622.1|Oceanobacter sp. RED65 YP 004749268.1|Acidithiobacillus caldus SM-1 YP 002951500.1|Desulfovibrio magneticus RS-1

100

YP 005050922.1|Desulfovibrio africanus str. Walvis Bay ZP 09907917.1|Sphingobium yanoikuyae XLDN2-5 85

YP 561605.1|Shewanella denitrificans OS217 ZP 09091155.1|Mesorhizobium amorphae CCNWGS0123 YP 003367240.1|Citrobacter rodentium ICC168 ZP 06549896.1|Klebsiella sp. 1 1 55

100 100

0.1

YP 002239575.1|Klebsiella pneumoniae 342

CBA32588.1|Curvibacter putative symbiont of Hydra magnipapillata

65 88

YP 982698.1|Polaromonas naphthalenivorans CJ2 YP 973384.1|Polaromonas naphthalenivorans CJ2

83

ML

ZP 10156634.1|Hydrogenophaga sp. PBC 99

YP 999248.1|Verminephrobacter eiseniae EF01-2 YP 004785026.1|Acidithiobacillus ferrivorans SS3 YP 004784773.1|Acidithiobacillus ferrivorans SS3

100

89 YP 004784777.1|Acidithiobacillus ferrivorans SS3

ZP 02367662.1|Burkholderia oklahomensis C6786 YP 002233619.1|Burkholderia cenocepacia J2315 ZP 10023820.1|Burkholderia sp. SJ98 gi|356685786|gb|EHI50407.1|Aeromonas salmonicida subsp. salmonicida 01-B526

98

YP 004392732.1|Aeromonas veronii B565 YP 973618.1|Polaromonas naphthalenivorans CJ2 YP 003846766.1|Gallionella capsiferriformans ES-2 100

YP 004693596.1|Nitrosomonas sp. Is79A3 YP 003461264.1|Thioalkalivibrio sp. K90mix ZP 06157762.1|Photobacterium damselae subsp. damselae CIP 102761

93

100 YP 004249870.1|Klebsiella pneumoniae

ZP 07133366.1|Escherichia coli MS 115-1 ZP 10892581.1|Klebsiella sp. OBRC7

100

YP 002932350.1|Edwardsiella ictaluri 93-146

99 100

YP 002932960.1|Edwardsiella ictaluri 93-146 YP 002933640.1|Edwardsiella ictaluri 93-146 YP 004749268.1|Acidithiobacillus caldus SM-1 ZP 01305622.1|Oceanobacter sp. RED65 Rhe0809

100

Rhe1806 Rfe p76-77 100

RfeI1 p75-77

100

Rfe pd43-44 Rma 0518-19

Plasmids and chromosomes

96

Rma 0296-97 Rma 1062-63 100

Rma 1249-50 Rma 1627-28 YP 002951500.1|Desulfovibrio magneticus RS-1

100

YP 005050922.1|Desulfovibrio africanus str. Walvis Bay ZP 09907917.1|Sphingobium yanoikuyae XLDN2-5 74

YP 561605.1|Shewanella denitrificans OS217 ZP 09091155.1|Mesorhizobium amorphae CCNWGS0123 YP 003367240.1|Citrobacter rodentium ICC168 ZP 06549896.1|Klebsiella sp. 1 1 55

100 100

0.1

YP 002239575.1|Klebsiella pneumoniae 342

Figure A75. Neighbor-joining (NJ) and maximum likelihood (ML) trees of NAD-dependent epimerase/dehydratase family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

Rhe p41

99

Rra2 p008

100

NJ

Reis2 p64 Reis4 p160064

90

100

Plasmids

100 ZP 00374403.1|Wolbachia endosymbiont of Drosophila ananassae

NP 966379.1| Wolbachia endosymbiont of Drosophila melanogaster 100

ZP 09542492.1| Wolbachia pipientis wAlbB 100

ZP 08970994.1| Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 01754997.1| Roseobacter sp. SK209-2-6 ZP 09702312.1| Methanoplanus limicola DSM 2279

ZP 09550635.1| Caldithrix abyssi DSM 13497 100

ZP 07686698.1|Oscillochloris trichoides DG6

0.2

99 Rhe p41

Rra2 p008

99

ML

Reis2 p64 100

Plasmids

Reis4 p160064

98

100 ZP 00374403.1|Wolbachia endosymbiont of Drosophila ananassae

NP 966379.1| Wolbachia endosymbiont of Drosophila melanogaster 100

ZP 09542492.1| Wolbachia pipientis wAlbB 99

ZP 08970994.1| Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 01754997.1| Roseobacter sp. SK209-2-6

ZP 09702312.1| Methanoplanus limicola DSM 2279 ZP 09550635.1| Caldithrix abyssi DSM 13497 100

0.2

ZP 07686698.1|Oscillochloris trichoides DG6

Figure

A76.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

glycosyltransferase, group 1 family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ Reis2 p63

99

Plasmids

Rhe p42 100

Rra2 p009-11 ZP 01314386.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24

100 99

NP 966380.1| Wolbachia endosymbiont of Drosophila melanogaster ZP 00372200.1|Wolbachia endosymbiont of Drosophila simulans

ZP 09542493.1|Wolbachia pipientis wAlbB 100

ZP 08970993.1| Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 01464208.1|Stigmatella aurantiaca DW4/3-1 YP 005321571-72|Saprospira grandis str. Lewin

0.1

Reis2 p63

100

Rhe p42

ML

100 100

Plasmids

Rra2 p009-11 ZP 00372200.1|Wolbachia endosymbiont of Drosophila simulans

100

NP 966380.1| Wolbachia endosymbiont of Drosophila melanogaster ZP 01314386.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24

99

ZP 09542493.1|Wolbachia pipientis wAlbB 98

ZP 08970993.1| Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 01464208.1|Stigmatella aurantiaca DW4/3-1 YP 005321571-72|Saprospira grandis str. Lewin

0.1

Figure A77. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

Reis2 p62

100

NJ

Rhe p43 100

Plasmids

Rra2 p012

76 ZP 00372201.1|Wolbachia endosymbiont of Drosophila simulans 100 YP 002727144.1|Wolbachia sp. wRi 96

NP 966381.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 09542494.1|Wolbachia pipientis wAlbB 100

ZP 08970992.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis

ZP 01314385.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24 YP 003265293.1|Haliangium ochraceum DSM 14365

0.2

100

Reis2 p62 Rhe p43

ML

100

Plasmids

Rra2 p012

73 ZP 00372201.1|Wolbachia endosymbiont of Drosophila simulans 60 YP 002727144.1|Wolbachia sp. wRi

NP 966381.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 09542494.1|Wolbachia pipientis wAlbB 100

ZP 08970992.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis

ZP 01314385.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24 YP 003265293.1|Haliangium ochraceum DSM 14365

0.2

Figure A78. Neighbor-joining (NJ) and maximum likelihood (ML) trees of phytanoyl-CoA dioxygenase family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ Reis2 p61

100

Rhe p44

Plasmids

Rra2 p013

98 100

100 ZP 00372202.1|Wolbachia endosymbiont of Drosophila simulans 77

NP 966382.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 09542495.1|Wolbachia pipientis wAlbB

99

ZP 08970959.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis EGY29824.1|Ca. Regiella insecticola R515 YP 003267229.1|Haliangium ochraceum DSM 14365 100 YP 003265415.1|Haliangium ochraceum DSM 14365

0.2

ZP 09542495.1|Wolbachia pipientis wAlbB

76

ML

88 ZP 08970959.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis

ZP 00372202.1|Wolbachia endosymbiont of Drosophila simulans 91

99 NP 966382.1|Wolbachia endosymbiont of Drosophila melanogaster

Reis2 p61 72 84

Plasmids

Rhe p44 Rra2 p013

EGY29824.1|Ca. Regiella insecticola R515 YP 003267229.1|Haliangium ochraceum DSM 14365 100 YP 003265415.1|Haliangium ochraceum DSM 14365

0.2

Figure A79. Neighbor-joining (NJ) and maximum likelihood (ML) trees of L-allo-threonine aldolase. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ Reis2 p57

100

Rhe p47

Plasmids

Rra2 p017

100

ZP 00372205.1|Wolbachia endosymbiont of Drosophila simulans

100 63 82 97 100

ZP 01314799.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24 NP 966385.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 08970956.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 09542498.1|Wolbachia pipientis wAlbB

100

EGY27736.1|Candidatus Regiella insecticola R5.15 YP 002509736.1|Halothermothrix orenii H 168

99

YP 005835521.1|Halanaerobium praevalens DSM 2228 59

YP 003529187.1|Nitrosococcus halophilus Nc4 YP 947661.1|Arthrobacter aurescens TC1 YP 002534484.1|Thermotoga neapolitana DSM 4359 YP 004819050.1|Thermoanaerobacter wiegelii Rt8.B1

99 100

ZP 05091804.1|Carboxydibrachium pacificum DSM 12653 99 Rhe p46 100

Rra2 p016

Plasmids

Reis2 p58

100

ZP 09542497.1|Wolbachia pipientis wAlbB 100

ZP 01314800.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24

97 NP 966384.1|Wolbachia endosymbiont of Drosophila melanogaster

ZP 08970957.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis 100

83 YP 004983511.1|Geobacillus thermoleovorans CCB US3 UF5 99 100

YP 148617.1|Geobacillus kaustophilus HTA426 YP 003670350.1|Geobacillus sp. C56-T3 YP 002315385.1|Anoxybacillus flavithermus WK1

100

ZP 04099208.1|Bacillus thuringiensis serovar andalousiensis BGSC 4AW1 100

0.1

ZP 04248861.1|Bacillus cereus Rock1-3

Reis2 p58

96

ML

Plasmids

Rhe p46 100

Rra2 p016

100

ZP 01314800.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24 91

100

100

NP 966384.1|Wolbachia endosymbiont of Drosophila melanogaster ZP 08970957.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 09542497.1|Wolbachia pipientis wAlbB

ZP 04099208.1|Bacillus thuringiensis serovar andalousiensis BGSC 4AW1

100

ZP 04248861.1|Bacillus cereus Rock1-3 YP 002315385.1|Anoxybacillus flavithermus WK1

99

YP 004983511.1|Geobacillus thermoleovorans CCB US3 UF5

100 86

YP 148617.1|Geobacillus kaustophilus HTA426 YP 003670350.1|Geobacillus sp. C56-T3

YP 002534484.1|Thermotoga neapolitana DSM 4359 YP 004819050.1|Thermoanaerobacter wiegelii Rt8.B1

97 100 94

ZP 05091804.1|Carboxydibrachium pacificum DSM 12653

YP 002509736.1|Halothermothrix orenii H 168 YP 005835521.1|Halanaerobium praevalens DSM 2228 YP 003529187.1|Nitrosococcus halophilus Nc4

100

YP 947661.1|Arthrobacter aurescens TC1 EGY27736.1|Candidatus Regiella insecticola R5.15 76

100 100

Rhe p47 Rra2 p017

98

Plasmids

Reis2 p57 ZP 09542498.1|Wolbachia pipientis wAlbB 100

NP 966385.1|Wolbachia endosymbiont of Drosophila melanogaster 100

ZP 00372205.1|Wolbachia endosymbiont of Drosophila simulans ZP 08970956.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 01314799.1|Wolbachia endosymbiont of Drosophila willistoni TSC*14030-0811.24

0.2

Figure A80. Neighbor-joining (NJ) and maximum likelihood (ML) trees of ABC multidrug transporter, permease/ATP-binding protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ Reis2 p60

100

Rhe p45 100

100 100

Plasmids

Rra2 p015

ZP 08970958.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 09542496.1|Wolbachia pipientis wAlbB

97

100

NP 966383.1|Wolbachia endosymbiont of Drosophila melanogaster 100 ZP 00372203.1|Wolbachia endosymbiont of Drosophila simulans

YP 001937222.1|Orientia tsutsugamushi str. Ikeda 82

ZP 08778541.1|Candidatus Odyssella thessalonicensis L13 YP 001496633.1|Rickettsia bellii OSU 85-389

76

YP 001958044.1|Candidatus Amoebophilus asiaticus 5a2 ZP 06300502.1|Parachlamydia acanthamoebae str. Halls coccus

99

YP 122209.1|Legionella pneumophila str. Paris YP 002727043.1|Wolbachia sp. wRi

92

ZP 10140421.1|Fluoribacter dumoffii Tex-KL

100

YP 095642.1|Legionella pneumophila subsp. pneumophila str. Philadelphia 1

100 100

YP 126755.1|Legionella pneumophila str. Lens

0.1

ML 100

Reis2 p60 Rhe p45 100

100 76

Plasmids

Rra2 p015

ZP 08970958.1|Wolbachia endosymbiont wVitB of Nasonia vitripennis ZP 09542496.1|Wolbachia pipientis wAlbB

93

100

NP 966383.1|Wolbachia endosymbiont of Drosophila melanogaster

100 ZP 00372203.1|Wolbachia endosymbiont of Drosophila simulans 88

YP 001937222.1|Orientia tsutsugamushi str. Ikeda ZP 08778541.1|Candidatus Odyssella thessalonicensis L13 YP 001496633.1|Rickettsia bellii OSU 85-389 65

YP 001958044.1|Candidatus Amoebophilus asiaticus 5a2 ZP 06300502.1|Parachlamydia acanthamoebae str. Halls coccus

92

YP 122209.1|Legionella pneumophila str. Paris YP 002727043.1|Wolbachia sp. wRi ZP 10140421.1|Fluoribacter dumoffii Tex-KL

100

YP 095642.1|Legionella pneumophila subsp. pneumophila str. Philadelphia 1

100 100

0.2

YP 126755.1|Legionella pneumophila str. Lens

Figure A81. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transaminase BioA gene. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

99 100 100

YP 001010064.1|Prochlorococcus marinus str. AS9601 YP 001484939.1|Prochlorococcus marinus str. MIT 9215 YP 398061.1|Prochlorococcus marinus str. MIT 9312

ZP 05790130.1|Synechococcus sp. WH 8109 YP 172176.1|Synechococcus elongatus PCC 6301

78

ZP 01125956.1|Nitrococcus mobilis Nb-231 ZP 06299038.1|Parachlamydia acanthamoebae str. Halls coccus 97

ZP 07113913.1|Oscillatoria sp. PCC 6506

60 100

ZP 08490700.1|Microcoleus vaginatus FGP-2

gi|356882413|emb|CCD03425.1|Azospirillum gi|144898116|emb|CAM74980.1|Magnetospirillum gryphiswaldense MSR-1

99

ZP 09876491.1|Phaeospirillum molischianum DSM 120

100

YP 422126.1|Magnetospirillum magneticum AMB-1

91 100

ZP 00053870.1|Magnetospirillum magnetotacticum MS-1 ZP 08777995.1|Candidatus Odyssella thessalonicensis L13 100

69

87

YP 003081804.1|Neorickettsia risticii str. Illinois YP 506498.1|Neorickettsia sennetsu str. Miyayama YP 004679453.1|Candidatus Midichloria mitochondrii IricVA ZP 09478122.1|Advenella kashmirensis WT001

68

YP 594802.1|Lawsonia intracellularis PHE/MN1-00

65

Reis2 p20

100

100 Reis2 p50

Plasmid YP 004318527.1|Sphingobacterium sp. 21 NP 225235.1|Chlamydophila pneumoniae CWL029

99 100

0.1

YP 004422547.1|Chlamydophila psittaci 6BC

YP 001010064.1|Prochlorococcus marinus str. AS9601

96

ML

100 100

YP 001484939.1|Prochlorococcus marinus str. MIT 9215 YP 398061.1|Prochlorococcus marinus str. MIT 9312

ZP 05790130.1|Synechococcus sp. WH 8109 ZP 01125956.1|Nitrococcus mobilis Nb-231 YP 172176.1|Synechococcus elongatus PCC 6301 ZP 06299038.1|Parachlamydia acanthamoebae str. Halls coccus ZP 07113913.1|Oscillatoria sp. PCC 6506

90 100

ZP 08490700.1|Microcoleus vaginatus FGP-2

gi|356882413|emb|CCD03425.1|Azospirillum gi|144898116|emb|CAM74980.1|Magnetospirillum gryphiswaldense MSR-1

100

ZP 09876491.1|Phaeospirillum molischianum DSM 120

100

YP 422126.1|Magnetospirillum magneticum AMB-1 100

ZP 00053870.1|Magnetospirillum magnetotacticum MS-1 NP 225235.1|Chlamydophila pneumoniae CWL029

100 100

YP 004422547.1|Chlamydophila psittaci 6BC YP 004318527.1|Sphingobacterium sp. 21 ZP 08777995.1|Candidatus Odyssella thessalonicensis L13 YP 003081804.1|Neorickettsia risticii str. Illinois

100 76

62

YP 506498.1|Neorickettsia sennetsu str. Miyayama YP 004679453.1|Candidatus Midichloria mitochondrii IricVA ZP 09478122.1|Advenella kashmirensis WT001

90

YP 594802.1|Lawsonia intracellularis PHE/MN1-00

76 100

Reis2 p20 100 Reis2 p50

0.1

Plasmid

Figure A82. Neighbor-joining (NJ) and maximum likelihood (ML) trees of dethiobiotin synthase BioD gene. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

88 99 76 100

YP 003980403.1|Achromobacter xylosoxidans A8 ZP 06685981.1|Achromobacter piechaudii ATCC 43553 gi|317406706|gb|EFV86868.1|Achromobacter xylosoxidans C54 NP 884044.1|Bordetella parapertussis 12822

98

YP 786964.1|Bordetella avium 197N ZP 06834784.1|Gluconacetobacter hansenii ATCC 23769

97

83

ZP 08697756.1|Acetobacter aceti NBRC 14818 gi|144898115|emb|CAM74979.1|Magnetospirillum gryphiswaldense MSR-1 ZP 09876492.1|Phaeospirillum molischianum DSM 120

100

YP 422125.1|Magnetospirillum magneticum AMB-1

69

61

99

ZP 00053869.2|Magnetospirillum magnetotacticum MS-1 YP 001528568.1|Desulfococcus oleovorans Hxd3 ZP 01125955.1|Nitrococcus mobilis Nb-231 YP 172177.1|Synechococcus elongatus PCC 6301 ZP 07018172.1|Desulfonatronospira thiodismutans ASO3-1 NP 699677.1|Brucella suis 1330 100

ZP 07473348.1|Brucella sp. BO2 ZP 06098255.1|Brucella sp. 83/13

ZP 09478121.1|Advenella kashmirensis WT001 YP 004679128.1|Candidatus Midichloria mitochondrii IricVA ZP 08777996.1|Candidatus Odyssella thessalonicensis L13 72 100

YP 594801.1|Lawsonia intracellularis PHE/MN1-00 Reis2 p21 100 Reis2 p49

Plasmid YP 001484938.1|Prochlorococcus marinus str. MIT 9215

100 83

0.1

YP 001010063.1|Prochlorococcus marinus str. AS9601 YP 001091885.1|Prochlorococcus marinus str. MIT 9301

89

YP 003980403.1|Achromobacter xylosoxidans A8

98

ML

ZP 06685981.1|Achromobacter piechaudii ATCC 43553 gi|317406706|gb|EFV86868.1|Achromobacter xylosoxidans C54

99

NP 884044.1|Bordetella parapertussis 12822 YP 786964.1|Bordetella avium 197N

77

ZP 06834784.1|Gluconacetobacter hansenii ATCC 23769 ZP 08697756.1|Acetobacter aceti NBRC 14818

98

gi|144898115|emb|CAM74979.1|Magnetospirillum gryphiswaldense MSR-1 ZP 09876492.1|Phaeospirillum molischianum DSM 120

98

YP 422125.1|Magnetospirillum magneticum AMB-1

79 93

ZP 00053869.2|Magnetospirillum magnetotacticum MS-1 YP 001528568.1|Desulfococcus oleovorans Hxd3 ZP 01125955.1|Nitrococcus mobilis Nb-231 YP 172177.1|Synechococcus elongatus PCC 6301

61

ZP 07018172.1|Desulfonatronospira thiodismutans ASO3-1 ZP 07473348.1|Brucella sp. BO2 100

ZP 06098255.1|Brucella sp. 83/13 NP 699677.1|Brucella suis 1330

ZP 09478121.1|Advenella kashmirensis WT001 YP 004679128.1|Candidatus Midichloria mitochondrii IricVA ZP 08777996.1|Candidatus Odyssella thessalonicensis L13 78

100 Reis2 p21 100

Reis2 p49

Plasmid

YP 594801.1|Lawsonia intracellularis PHE/MN1-00 YP 001484938.1|Prochlorococcus marinus str. MIT 9215 100

YP 001010063.1|Prochlorococcus marinus str. AS9601 YP 001091885.1|Prochlorococcus marinus str. MIT 9301

0.2

Figure A83. Neighbor-joining (NJ) and maximum likelihood (ML) trees of dethiobiotin synthase BioC gene. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 73 YP 003666311.1|Bacillus thuringiensis BMB171

NP 833833.1|Bacillus cereus ATCC 14579 ZP 09355282.1|Bacillus sp. 7 6 55CFAA CT2

100 88 ZP 03232242.1|Bacillus cereus AH1134 97

ZP 00739343.1|Bacillus thuringiensis serovar israelensis ATCC 35646 YP 002751479.1|Bacillus cereus 03BB102

99

100

ZP 04313527.1|Bacillus cereus BGSC 6E1 YP 896467.1|Bacillus thuringiensis str. Al Hakam

100

YP 001646742.1|Bacillus weihenstephanensis KBAB4 YP 001376042.1|Bacillus cytotoxicus NVH 391-98 100

YP 002315526.1|Anoxybacillus flavithermus WK1

69

ZP 09353241.1|Bacillus smithii 7 3 47FAA 100 71

YP 003564164.1|Bacillus megaterium QM B1551 YP 003598878.1|Bacillus megaterium DSM 319 100 YP 001036459.1|Clostridium thermocellum ATCC 27405

ZP 05430560.1|Clostridium thermocellum DSM 2360 100

YP 004495874.1|Desulfotomaculum carboxydivorans CO-1-SRB 100

ZP 08113318.1|Desulfotomaculum nigrificans DSM 574 ZP 09012133.1|Commensalibacter intestini A911 YP 506495.1|Neorickettsia sennetsu str. Miyayama

76

YP 004679129.1|Candidatus Midichloria mitochondrii IricVA

72

YP 594800.1|Lawsonia intracellularis PHE/MN1-00

69

Reis2 p22

99

100 Reis2 p48

Plasmid

YP 003263750.1|Halothiobacillus neapolitanus c2 ZP 03395879.1|Pseudomonas syringae pv. tomato T1

99

YP 004356653.1|Pseudomonas

100 96

0.2

YP 005210763.1|Pseudomonas fluorescens F113

YP 003666311.1|Bacillus thuringiensis BMB171 NP 833833.1|Bacillus cereus ATCC 14579 ZP 09355282.1|Bacillus sp. 7 6 55CFAA CT2

98 91 ZP 03232242.1|Bacillus cereus AH1134

ML

ZP 00739343.1|Bacillus thuringiensis serovar israelensis ATCC 35646

62

YP 002751479.1|Bacillus cereus 03BB102 97 98 100

ZP 04313527.1|Bacillus cereus BGSC 6E1 YP 896467.1|Bacillus thuringiensis str. Al Hakam YP 001646742.1|Bacillus weihenstephanensis KBAB4 YP 001376042.1|Bacillus cytotoxicus NVH 391-98

YP 002315526.1|Anoxybacillus flavithermus WK1 73

ZP 09353241.1|Bacillus smithii 7 3 47FAA YP 003564164.1|Bacillus megaterium QM B1551

100

100

YP 003598878.1|Bacillus megaterium DSM 319 100 YP 001036459.1|Clostridium thermocellum ATCC 27405

ZP 05430560.1|Clostridium thermocellum DSM 2360 97

YP 004495874.1|Desulfotomaculum carboxydivorans CO-1-SRB 100 ZP 08113318.1|Desulfotomaculum nigrificans DSM 574

ZP 09012133.1|Commensalibacter intestini A911 YP 506495.1|Neorickettsia sennetsu str. Miyayama

84

YP 004679129.1|Candidatus Midichloria mitochondrii IricVA YP 594800.1|Lawsonia intracellularis PHE/MN1-00 Reis2 p22

100

100 Reis2 p48

Plasmid

YP 003263750.1|Halothiobacillus neapolitanus c2 ZP 03395879.1|Pseudomonas syringae pv. tomato T1

100 100 85

0.2

YP 004356653.1|Pseudomonas YP 005210763.1|Pseudomonas fluorescens F113

Figure A84. Neighbor-joining (NJ) and maximum likelihood (ML) trees of alpha/beta hydrolase family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100 92

Reis2 p23 Reis2 p47

88

Plasmid

YP 594799.1|Lawsonia intracellularis PHE/MN1-00

100

YP 004679131.1|Candidatus Midichloria mitochondrii IricVA YP 506494.1|Neorickettsia sennetsu str. Miyayama 100

YP 003081801.1|Neorickettsia risticii str. Illinois

ZP 08777329.1|Candidatus Odyssella thessalonicensis L13 YP 003980402.1|Achromobacter xylosoxidans A8 100

ZP 09303134.1|Achromobacter arsenitoxydans SY8

0.2

100 Reis2 p23

ML

Reis2 p47 99

Plasmid

YP 594799.1|Lawsonia intracellularis PHE/MN1-00 YP 004679131.1|Candidatus Midichloria mitochondrii IricVA YP 506494.1|Neorickettsia sennetsu str. Miyayama

100

YP 003081801.1|Neorickettsia risticii str. Illinois ZP 08777329.1|Candidatus Odyssella thessalonicensis L13 YP 003980402.1|Achromobacter xylosoxidans A8

100 100

0.5

ZP 09303134.1|Achromobacter arsenitoxydans SY8

Figure A85. Neighbor-joining (NJ) and maximum likelihood (ML) trees of synthetase and related enzymes BioF gene. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ YP 003980401.1|Achromobacter xylosoxidans A8

84 97

ZP 06685979.1|Achromobacter piechaudii ATCC 43553

100

ZP 09303133.1|Achromobacter arsenitoxydans SY8 EGP48117.1|Achromobacter xylosoxidans AXX-A

100

NP 884046.1|Bordetella parapertussis 12822 100

NP 880814.1|Bordetella pertussis Tohama I

79

gi|356882409|emb|CCD03421.1|Azospirillum YP 786962.1|Bordetella avium 197N ZP 08697151.1|Acetobacter aceti NBRC 14818 100 YP 002274557.1|Gluconacetobacter diazotrophicus PAl 5 92

YP 001602165.1|Gluconacetobacter diazotrophicus PAl 5

95 86

YP 004867367.1|Gluconacetobacter xylinus NBRC 3288 89

ZP 06834782.1|Gluconacetobacter hansenii ATCC 23769 YP 004533348.1|Novosphingobium sp. PP1Y 100

ZP 09192529.1|Novosphingobium pentaromativorans US6-1 ZP 09876495.1|Phaeospirillum molischianum DSM 120

100

YP 422122.1|Magnetospirillum magneticum AMB-1

100 100

85

ZP 00053272.2|Magnetospirillum magnetotacticum MS-1 YP 863966.1|Magnetococcus sp. MC-1 YP 001805565.1|Cyanothece sp. ATCC 51142

93

EID44564.1|Geobacillus thermoglucosidans TNO-09.020 ZP 08777714.1|Candidatus Odyssella thessalonicensis L13 ZP 01914992.1|Limnobacter sp. MED105 ZP 09478120.1|Advenella kashmirensis WT001

96

100 73

98

YP 506493.1|Neorickettsia sennetsu str. Miyayama YP 003081800.1|Neorickettsia risticii str. Illinois YP 004679132.1|Candidatus Midichloria mitochondrii IricVA YP 006705757.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

76

100 Reis2 p24 97

Reis2 p46 89

0.1

Plasmid

YP 594798.1|Lawsonia intracellularis PHE/MN1-00

YP 003980401.1|Achromobacter xylosoxidans A8

81 89

ML

ZP 06685979.1|Achromobacter piechaudii ATCC 43553

99

ZP 09303133.1|Achromobacter arsenitoxydans SY8 EGP48117.1|Achromobacter xylosoxidans AXX-A

98

NP 884046.1|Bordetella parapertussis 12822 100 NP 880814.1|Bordetella pertussis Tohama I

gi|356882409|emb|CCD03421.1|Azospirillum YP 786962.1|Bordetella avium 197N YP 004533348.1|Novosphingobium sp. PP1Y 90

100 ZP 09192529.1|Novosphingobium pentaromativorans US6-1

ZP 08697151.1|Acetobacter aceti NBRC 14818 100 YP 002274557.1|Gluconacetobacter diazotrophicus PAl 5 75

YP 001602165.1|Gluconacetobacter diazotrophicus PAl 5 86

YP 004867367.1|Gluconacetobacter xylinus NBRC 3288 88

97

ZP 06834782.1|Gluconacetobacter hansenii ATCC 23769 ZP 09876495.1|Phaeospirillum molischianum DSM 120 YP 422122.1|Magnetospirillum magneticum AMB-1

100 100

86

ZP 00053272.2|Magnetospirillum magnetotacticum MS-1 YP 863966.1|Magnetococcus sp. MC-1 YP 001805565.1|Cyanothece sp. ATCC 51142

69

EID44564.1|Geobacillus thermoglucosidans TNO-09.020 ZP 08777714.1|Candidatus Odyssella thessalonicensis L13 ZP 01914992.1|Limnobacter sp. MED105 ZP 09478120.1|Advenella kashmirensis WT001

93

YP 506493.1|Neorickettsia sennetsu str. Miyayama

100 71

88

YP 003081800.1|Neorickettsia risticii str. Illinois YP 004679132.1|Candidatus Midichloria mitochondrii IricVA YP 006705757.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 594798.1|Lawsonia intracellularis PHE/MN1-00

75 98

Reis2 p24 100 Reis2 p46

0.2

Plasmid

Figure A86. Neighbor-joining (NJ) and maximum likelihood (ML) trees of biotin synthase BioB gene. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100 gi|381340061|emb|CCG96108.1|Marinobacter hydrocarbonoclasticus ATCC 49840 85

YP 960018.1|Marinobacter aquaeolei VT8

100

ZP 09158639.1|Marinobacter manganoxydans MnI7-9 ZP 01737939.1|Marinobacter sp. ELB17 ZP 09505812.1|Marinobacterium stanieri S30

64

99

ZP 01307870.1|Oceanobacter sp. RED65 ZP 09504946.1|Alteromonas sp. S89 ZP 01043921.1|Idiomarina

100

YP 155713.1|Idiomarina loihiensis L2TR YP 002892309.1|Tolumonas auensis DSM 9187 YP 004871468.1|Glaciecola nitratireducens FR1064

99

NP 660626.1|Buchnera aphidicola str. Sg (Schizaphis graminum) YP 002150372.1|Proteus mirabilis HI4320 gi|284007137|emb|CBA72414.1|Arsenophonus nasoniae

97

YP 454583.1|Sodalis glossinidius str. morsitans 84

64

67

YP 002918554.1|Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 YP 003711704.1|Xenorhabdus nematophila ATCC 19061

87

YP 003466956.1|Xenorhabdus 99

NP 928780.1|Photorhabdus luminescens subsp. laumondii TTO1 99

YP 003041771.1|Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949

YP 934320.1|Azoarcus sp. BH72 CAM75418.1|Magnetospirillum gryphiswaldense MSR-1 ZP 08776752.1|Candidatus Odyssella thessalonicensis L13 100 74

YP 003081798.1|Neorickettsia risticii str. Illinois YP 506492.1|Neorickettsia sennetsu str. Miyayama

96

gi|269308637|gb|ACZ34281.1|Heterodera glycines YP 004679133.1|Candidatus Midichloria mitochondrii IricVA YP 006705756.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella 100

Rfe0667 Rhe1449-1450

100 Reis2 p25

64

Reis2 p45 64

0.1

Plasmid YP 594797.1|Lawsonia intracellularis PHE/MN1-00

gi|381340061|emb|CCG96108.1|Marinobacter hydrocarbonoclasticus ATCC 49840

100

ML

52

YP 960018.1|Marinobacter aquaeolei VT8

100

ZP 09158639.1|Marinobacter manganoxydans MnI7-9 ZP 01737939.1|Marinobacter sp. ELB17 ZP 09504946.1|Alteromonas sp. S89

29

ZP 01043921.1|Idiomarina

33 100

YP 155713.1|Idiomarina loihiensis L2TR

31

ZP 09505812.1|Marinobacterium stanieri S30 99

72

ZP 01307870.1|Oceanobacter sp. RED65 YP 002892309.1|Tolumonas auensis DSM 9187 YP 004871468.1|Glaciecola nitratireducens FR1064

92

NP 660626.1|Buchnera aphidicola str. Sg (Schizaphis graminum) YP 002150372.1|Proteus mirabilis HI4320 76

gi|284007137|emb|CBA72414.1|Arsenophonus nasoniae YP 454583.1|Sodalis glossinidius str. morsitans

48 82

YP 002918554.1|Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044 YP 003711704.1|Xenorhabdus nematophila ATCC 19061

77

53

YP 003466956.1|Xenorhabdus 85

NP 928780.1|Photorhabdus luminescens subsp. laumondii TTO1 98

YP 003041771.1|Photorhabdus asymbiotica subsp. asymbiotica ATCC 43949 YP 934320.1|Azoarcus sp. BH72 CAM75418.1|Magnetospirillum gryphiswaldense MSR-1 100

60

YP 003081798.1|Neorickettsia risticii str. Illinois YP 506492.1|Neorickettsia sennetsu str. Miyayama

gi|269308637|gb|ACZ34281.1|Heterodera glycines

12

YP 004679133.1|Candidatus Midichloria mitochondrii IricVA 30

ZP 08776752.1|Candidatus Odyssella thessalonicensis L13

2

YP 006705756.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella Rfe0667

100 28

Rhe1449-1450 100

59

Reis2 p25 Reis2 p45

61

0.05

Plasmid YP 594797.1|Lawsonia intracellularis PHE/MN1-00

Figure A87. Neighbor-joining (NJ) and maximum likelihood (ML) trees of acetyltransferase. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100

Rpe p13 Rra0909

68

Plasmid and chromosome

AF332547 9Pseudomonas aeruginosa 60

YP 005976533.1|Pseudomonas aeruginosa M18 EGM23636.1|Pseudomonas aeruginosa 138244

100

ZP 01364457.1|Pseudomonas aeruginosa PACS2 69

YP 258787.1|Pseudomonas protegens Pf-5 YP 003375896.1|Xanthomonas albilineans GPE PC73

100 100

ZP 09854521.1|Xanthomonas sacchari NCPPB 4393

YP 004851553.1|Xanthomonas axonopodis pv. citrumelo F1 99

YP 363737.1|Xanthomonas campestris pv. vesicatoria str. 85-10 ZP 09854097.1|Xanthomonas sacchari NCPPB 4393 YP 005628659.1|Xanthomonas oryzae pv. oryzicola BLS256 YP 546751.1|Methylobacillus flagellatus KT

100

NP 642285.1|Xanthomonas axonopodis pv. citri str. 306

78

ZP 06702830.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122

99

ZP 10263605.1|Xanthomonas axonopodis pv. punicae str. LMG 859 YP 201236.1|Xanthomonas oryzae pv. oryzae KACC 10331 ZP 08184971.1|Xanthomonas gardneri ATCC 19865 85

YP 005637206.1|Xanthomonas campestris pv. raphani 756C

0.2

ML

100

Rpe p13 Rra0909

68

Plasmid and chromosome

EGM23636.1|Pseudomonas aeruginosa 138244 YP 005976533.1|Pseudomonas aeruginosa M18 99 ZP 01364457.1|Pseudomonas aeruginosa PACS2

AF332547 9Pseudomonas aeruginosa

100

YP 258787.1|Pseudomonas protegens Pf-5 YP 004851553.1|Xanthomonas axonopodis pv. citrumelo F1 99 YP 363737.1|Xanthomonas campestris pv. vesicatoria str. 85-10

YP 003375896.1|Xanthomonas albilineans GPE PC73 100

ZP 09854521.1|Xanthomonas sacchari NCPPB 4393 ZP 09854097.1|Xanthomonas sacchari NCPPB 4393

YP 005628659.1|Xanthomonas oryzae pv. oryzicola BLS256 YP 546751.1|Methylobacillus flagellatus KT 99

ZP 06702830.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 ZP 10263605.1|Xanthomonas axonopodis pv. punicae str. LMG 859 62 75 71

NP 642285.1|Xanthomonas axonopodis pv. citri str. 306 YP 201236.1|Xanthomonas oryzae pv. oryzae KACC 10331 ZP 08184971.1|Xanthomonas gardneri ATCC 19865

84

0.2

YP 005637206.1|Xanthomonas campestris pv. raphani 756C

Figure A88. Neighbor-joining (NJ) and maximum likelihood (ML) trees of rieske non-heme iron oxygenase (RO) family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100

Rpe p14 Rra 0910

Plasmid and chromosome

67 ZP 04932773.1|Pseudomonas aeruginosa 2192

ZP 09055265.1|Pseudomonas sp. 2 1 26 100 99

ZP 01364456.1|Pseudomonas aeruginosa PACS2 YP 258786.1|Pseudomonas fluorescens Pf-5 YP 363738.1|Xanthomonas campestris pv. vesicatoria str. 85-10 ZP 09854522.1|Xanthomonas sacchari NCPPB 4393

99 100

YP 003375897.1|Xanthomonas albilineans GPE PC73 YP 001561641.1|Delftia acidovorans SPH-1

77

YP 546750.1|Methylobacillus flagellatus KT ZP 08180461.1|Xanthomonas vesicatoria ATCC 35937

100

ZP 08189172.1|Xanthomonas perforans 91-118

91

YP 005637207.1|Xanthomonas campestris pv. raphani 756C

93 93 67

ZP 08184970.1|Xanthomonas gardneri ATCC 19865 YP 201235.1|Xanthomonas oryzae pv. oryzae KACC 10331 YP 787575.1|Bordetella avium 197N

0.2

100

ML

Rpe p14 Rra 0910

Plasmid and chromosome

ZP 04932773.1|Pseudomonas aeruginosa 2192 98

ZP 09055265.1|Pseudomonas sp. 2 1 26 ZP 01364456.1|Pseudomonas aeruginosa PACS2

86

YP 258786.1|Pseudomonas fluorescens Pf-5 YP 363738.1|Xanthomonas campestris pv. vesicatoria str. 85-10 ZP 09854522.1|Xanthomonas sacchari NCPPB 4393

85 98

YP 003375897.1|Xanthomonas albilineans GPE PC73 YP 001561641.1|Delftia acidovorans SPH-1

74

YP 546750.1|Methylobacillus flagellatus KT ZP 08180461.1|Xanthomonas vesicatoria ATCC 35937

100

ZP 08189172.1|Xanthomonas perforans 91-118 YP 201235.1|Xanthomonas oryzae pv. oryzae KACC 10331

80 97 96

YP 005637207.1|Xanthomonas campestris pv. raphani 756C ZP 08184970.1|Xanthomonas gardneri ATCC 19865 YP 787575.1|Bordetella avium 197N

0.2

Figure A89. Neighbor-joining (NJ) and maximum likelihood (ML) trees of short chain dehydrogenase/reductase family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ ZP 06487653.1|Xanthomonas campestris pv. vasculorum NCPPB 702

100

NP 642288.1|Xanthomonas axonopodis pv. citri str. 306

82

YP 546748.1|Methylobacillus flagellatus KT 90

YP 001561643.1|Delftia acidovorans SPH-1 ZP 08184968.1|Xanthomonas gardneri ATCC 19865 YP 005628662.1|Xanthomonas oryzae pv. oryzicola BLS256

100

100

60

YP 001913706.1|Xanthomonas oryzae pv. oryzae PXO99A

98 YP 201233.1|Xanthomonas oryzae pv. oryzae KACC 10331

ZP 08189174.1|Xanthomonas perforans 91-118 ZP 10263601.1|Xanthomonas axonopodis pv. punicae str. LMG 859

100

ZP 06730841.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535 YP 003606627.1|Burkholderia sp. CCGE1002 YP 003052552.1|Methylovorus glucosetrophus SIP3-4 100

YP 258784.1|Pseudomonas fluorescens Pf-5 76

Rpe p15

100

Rra0911

Plasmid and chromosome

100 ZP 01364454.1|Pseudomonas aeruginosa PACS2

90

AAP35716.1|Pseudomonas aeruginosa YP 005976536.1|Pseudomonas aeruginosa M18

86

ZP 04932771.1|Pseudomonas aeruginosa 2192

100

82 AF332547 6Pseudomonas aeruginosa

YP 004041107.1|Methylovorus sp. MP688 YP 004041106.1|Methylovorus sp. MP688 ZP 06487652.1|Xanthomonas campestris pv. vasculorum NCPPB 702 YP 001561644.1|Delftia acidovorans SPH-1

63

100 100

ZP 06702910.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 ZP 09879232.1|Xanthomonas citri pv. mangiferaeindicae LMG 941

95

YP 005637210.1|Xanthomonas campestris pv. raphani 756C ZP 08184967.1|Xanthomonas gardneri ATCC 19865

100 77

YP 005628663.1|Xanthomonas oryzae pv. oryzicola BLS256 YP 451480.1|Xanthomonas oryzae pv. oryzae MAFF 311018

YP 001349638.1|Pseudomonas aeruginosa PA7 ZP 09854524.1|Xanthomonas sacchari NCPPB 4393 100

0.1

YP 363740.1|Xanthomonas campestris pv. vesicatoria str. 85-10

ZP 06487653.1|Xanthomonas campestris pv. vasculorum NCPPB 702

100

NP 642288.1|Xanthomonas axonopodis pv. citri str. 306

87

ML

YP 546748.1|Methylobacillus flagellatus KT 78

YP 001561643.1|Delftia acidovorans SPH-1 ZP 08184968.1|Xanthomonas gardneri ATCC 19865 YP 005628662.1|Xanthomonas oryzae pv. oryzicola BLS256 100

97

YP 001913706.1|Xanthomonas oryzae pv. oryzae PXO99A

95 YP 201233.1|Xanthomonas oryzae pv. oryzae KACC 10331

ZP 08189174.1|Xanthomonas perforans 91-118 ZP 10263601.1|Xanthomonas axonopodis pv. punicae str. LMG 859

99

ZP 06730841.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535 YP 003606627.1|Burkholderia sp. CCGE1002 YP 003052552.1|Methylovorus glucosetrophus SIP3-4 90

YP 258784.1|Pseudomonas fluorescens Pf-5 100

Rpe p15 Rra0911

Plasmid and chromosome

100 ZP 01364454.1|Pseudomonas aeruginosa PACS2

gi|30844213|gb|AAP35716.1|Pseudomonas aeruginosa ZP 04932771.1|Pseudomonas aeruginosa 2192

64 99

YP 005976536.1|Pseudomonas aeruginosa M18 gi|13183738|gb|AAK15329.1|AF332547 6Pseudomonas aeruginosa YP 004041107.1|Methylovorus sp. MP688 YP 004041106.1|Methylovorus sp. MP688

96 100

YP 005637210.1|Xanthomonas campestris pv. raphani 756C ZP 08184967.1|Xanthomonas gardneri ATCC 19865

66

YP 005628663.1|Xanthomonas oryzae pv. oryzicola BLS256 YP 451480.1|Xanthomonas oryzae pv. oryzae MAFF 311018 98

ZP 06487652.1|Xanthomonas campestris pv. vasculorum NCPPB 702 YP 001561644.1|Delftia acidovorans SPH-1 ZP 06702910.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 100

ZP 09879232.1|Xanthomonas citri pv. mangiferaeindicae LMG 941

YP 001349638.1|Pseudomonas aeruginosa PA7 ZP 09854524.1|Xanthomonas sacchari NCPPB 4393

60 100

0.1

YP 363740.1|Xanthomonas campestris pv. vesicatoria str. 85-10

Figure A90. Neighbor-joining (NJ) and maximum likelihood (ML) trees of 3-oxoacyl-(acylcarrier-protein) synthase III. Bootstrap supports higher than or equal to 60% are shown on the branches.

Rpe p16

100

NJ

Rra 09111

Plasmid and chromosome

YP 005980196.1|Pseudomonas aeruginosa NCGM2.S1 85

ZP 07792304.1|Pseudomonas aeruginosa 39016 YP 001349639.1|Pseudomonas aeruginosa PA7 100

ZP 09055262.1|Pseudomonas sp. 2 1 26 ZP 01364453.1|Pseudomonas aeruginosa PACS2

77

YP 258783.1|Pseudomonas fluorescens Pf-5

93

ZP 09854526.1|Xanthomonas sacchari NCPPB 4393

79

YP 003375901.1|Xanthomonas albilineans GPE PC73 YP 363742.1|Xanthomonas campestris 98

100

ZP 08180465.1|Xanthomonas vesicatoria ATCC 35937

99

YP 005637211.1|Xanthomonas campestris

99

ZP 08184966.1|Xanthomonas gardneri ATCC 19865 97

YP 005628664.1|Xanthomonas oryzae 100

YP 201231.1|Xanthomonas oryzae

YP 546746.1|Methylobacillus flagellatus KT YP 003606628.1|Burkholderia sp. CCGE1002 ZP 06702909.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 75

YP 001561645.1|Delftia acidovorans SPH-1

0.05

Rpe p16

100

Rra 09111

ML

Plasmid and chromosome

YP 005980196.1|Pseudomonas aeruginosa NCGM2.S1 93

ZP 07792304.1|Pseudomonas aeruginosa 39016 100

ZP 01364453.1|Pseudomonas aeruginosa PACS2 ZP 09055262.1|Pseudomonas sp. 2 1 26

80

YP 001349639.1|Pseudomonas aeruginosa PA7

95

YP 258783.1|Pseudomonas fluorescens Pf-5 ZP 09854526.1|Xanthomonas sacchari NCPPB 4393

88

YP 003375901.1|Xanthomonas albilineans GPE PC73 YP 363742.1|Xanthomonas campestris

99

ZP 08180465.1|Xanthomonas vesicatoria ATCC 35937

98

100

YP 005637211.1|Xanthomonas campestris ZP 08184966.1|Xanthomonas gardneri ATCC 19865

99

YP 005628664.1|Xanthomonas oryzae 98

YP 201231.1|Xanthomonas oryzae

YP 546746.1|Methylobacillus flagellatus KT YP 003606628.1|Burkholderia sp. CCGE1002 100

ZP 06702909.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 YP 001561645.1|Delftia acidovorans SPH-1

0.05

Figure A91. Neighbor-joining (NJ) and maximum likelihood (ML) trees of acyl carrier protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 005628665.1|Xanthomonas oryzae pv. oryzicola BLS256 ZP 06487649.1|Xanthomonas campestris pv. vasculorum NCPPB 702

67

NJ

YP 201230.1|Xanthomonas oryzae pv. oryzae KACC 10331

66

77 YP 451478.1|Xanthomonas oryzae pv. oryzae MAFF 311018

ZP 08180466.1|Xanthomonas vesicatoria ATCC 35937 ZP 08184965.1|Xanthomonas gardneri ATCC 19865 YP 363743.1|Xanthomonas campestris pv. vesicatoria str. 85-10 NP 642291.1|Xanthomonas axonopodis pv. citri str. 306 YP 005637212.1|Xanthomonas campestris pv. raphani 756C YP 003375902.1|Xanthomonas albilineans GPE PC73 ZP 09854527.1|Xanthomonas sacchari NCPPB 4393

67

100

Rpe p17 Rra0914

90

Plasmid and chromosome

YP 001349640.1|Pseudomonas aeruginosa PA7 96

ZP 01364452.1|Pseudomonas aeruginosa PACS2

YP 258782.1|Pseudomonas fluorescens Pf-5 ZP 09879230.1|Xanthomonas citri pv. mangiferaeindicae LMG 941 97

ZP 08189177.1|Xanthomonas perforans 91-118 YP 003606629.1|Burkholderia sp. CCGE1002 99

YP 001561646.1|Delftia acidovorans SPH-1

0.05

90 YP 201230.1| Xanthomonas oryzae pv. oryzae KACC 10331

ML

61

YP 451478.1| Xanthomonas oryzae pv. oryzae MAFF 311018 YP 005628665.1| Xanthomonas oryzae pv. oryzicola BLS256 ZP 06487649.1|Xanthomonas campestris pv. vasculorum NCPPB 702

ZP 08180466.1| Xanthomonas vesicatoria ATCC 35937 ZP 08184965.1| Xanthomonas gardneri ATCC 19865 YP 363743.1|Xanthomonas campestris pv. vesicatoria str. 85-10 NP 642291.1| Xanthomonas axonopodis pv. citri str. 306 YP 005637212.1|Xanthomonas campestris pv. raphani 756C YP 003375902.1|Xanthomonas albilineans GPE PC73 ZP 09854527.1|Xanthomonas sacchari NCPPB 4393 100

Rpe p17 Rra0914

80

Plasmid and chromosome

YP 001349640.1| Pseudomonas aeruginosa PA7 98

ZP 01364452.1|Pseudomonas aeruginosa PACS2

YP 258782.1| Pseudomonas fluorescens Pf-5 93 ZP 09879230.1|Xanthomonas citri pv. mangiferaeindicae LMG 941

ZP 08189177.1| Xanthomonas perforans 91-118 YP 003606629.1|Burkholderia sp. CCGE1002 95

0.05

YP 001561646.1|Delftia acidovorans SPH-1

Figure A92. Neighbor-joining (NJ) and maximum likelihood (ML) trees of ABC multidrug transporter, permease/ATP-binding protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ YP 003123858.1|Chitinophaga pinensis DSM 2588

100

YP 005012739.1|Niastella koreensis GR20-10 gi|387853698|gb|AFK01795.1|Emticicia oligotrophica DSM 17448 YP 004448037.1|Haliscomenobacter hydrossis DSM 1100

68

YP 003084504.1|Dyadobacter fermentans DSM 18053

91 99

YP 004656191.1|Runella slithyformis DSM 19594

100

YP 004316153.1|Sphingobacterium sp. 21 gi|384068613|emb|CCH01823.1|Fibrella aestuarina BUZ 2

66

YP 003390337.1|Spirosoma linguale DSM 74 Rpe p18

100

Rra 0916 100

Plasmid and chromosome

YP 001958067.1|Candidatus Amoebophilus asiaticus 5a2 ZP 08607936.1|Lachnospiraceae bacterium 3 1 57FAA CT1

0.1

100

YP 003123858.1|Chitinophaga pinensis DSM 2588 YP 005012739.1|Niastella koreensis GR20-10

ML

YP 004448037.1|Haliscomenobacter hydrossis DSM 1100 gi|387853698|gb|AFK01795.1|Emticicia oligotrophica DSM 17448 YP 003084504.1|Dyadobacter fermentans DSM 18053

65 97

YP 004656191.1|Runella slithyformis DSM 19594

100

YP 004316153.1|Sphingobacterium sp. 21 gi|384068613|emb|CCH01823.1|Fibrella aestuarina BUZ 2 68

YP 003390337.1|Spirosoma linguale DSM 74 ZP 08607936.1|Lachnospiraceae bacterium 3 1 57FAA CT1 100

Rpe p18 Rra 0916

100

0.2

Plasmid and chromosome

YP 001958067.1|Candidatus Amoebophilus asiaticus 5a2

Figure A93. Neighbor-joining (NJ) and maximum likelihood (ML) trees of plasmid partitioning protein ParA. Bootstrap supports higher than or equal to 60% are shown on the branches.

97

NJ

ZP 09909938.1|Sphingobium yanoikuyae XLDN2-5 ZP 10543427.1|Sphingobium sp. AP49 YP 003544795.1|Sphingobium japonicum UT26S

80

YP 004552635.1|Sphingobium chlorophenolicum L-1 YP 616951.1|Sphingopyxis alaskensis ZP 01303560.1|Sphingomonas sp. SKA58 YP 004835198.1|Sphingobium sp. SYK-6 ZP 01864812.1|Erythrobacter sp. SD-21 YP 457100.1|Erythrobacter litoralis HTCC2594

88

ZP 01038678.1|Erythrobacter sp. NAP1 YP 498334.1|Novosphingobium aromaticivorans DSM 12444 ZP 08208528.1|Novosphingobium nitrogenifigens DSM 19370 ZP 06860883.1|Citromicrobium bathyomarinum JL354 97

ZP 08702876.1|Citromicrobium sp. JLT1363 ZP 10872513.1|Sphingomonas sp. LH128 ZP 10746713.1|Novosphingobium sp. AP12

6360

YP 004534555.1|Novosphingobium sp. PP1Y

76 99

ZP 09191027.1|Novosphingobium pentaromativorans US6-1 ZP 09140887.1|Sphingomonas sp. KC8

99

ZP 10425207.1|Sphingomonas sp. PAMC 26617 ZP 10344556.1|Sphingomonas sp. PAMC 26605

96 68

ZP 10338744.1|Sphingomonas echinoides ATCC 14820 ZP 09953370.1|Sphingomonas elodea ATCC 31461 YP 757396.1|Maricaulis maris MCS10

91

YP 184745.1|Laribacter hongkongensis YP 001411312.1|Parvibaculum lavamentivorans DS-1 99

84

ref|NC 009719.1| Parvibaculum lavamentivorans DS-1 chromosome complete genome ZP 10075793.1|Desulfovibrio sp. U5L

ZP 08634810.1|Acidiphilium sp. PM YP 361515.1|Xanthomonas campestris pv. vesicatoria str. 85-10

97

ZP 08666646.1|Paracoccus sp. TRP 99

79

99

YP 001965992.1|Xanthomonas axonopodis pv. glycines ref|NC 010872.1| Xanthomonas axonopodis pv. glycines plasmid pAG1 complete sequence

62

ZP 13085317.1|Xanthomonas axonopodis pv. malvacearum str. GSPB1386 99

ZP 06705664.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 YP 001776801.1|Methylobacterium radiotolerans JCM 2831 ZP 09287307.1|Pseudomonas psychrotolerans L19 YP 003162880.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1

79

ZP 09995471.1|Acidithiobacillus thiooxidans ATCC 19377 99

YP 003071359.1|Methylobacterium extorquens DM4 YP 002966225.1|Methylobacterium extorquens AM1

Pla smid Pla smid

Raf p14 Rau p11

93 99

ZP 08778844.1|Candidatus Odyssella thessalonicensis L13 YP 001770187.1|Methylobacterium sp. 4-46 ZP 07111127.1|Oscillatoria sp. PCC 6506 YP 002961220.1|Methylobacterium extorquens AM1 ZP 09875261.1|Phaeospirillum molischianum DSM 120 YP 068544.1|Yersinia pseudotuberculosis IP 32953

94

ZP 08390645.1|Sphingomonas sp. S17

63 98

ZP 11572143.1|Pseudomonas syringae pv. glycinea str. race 4

99

YP 004831088.1|Serratia marcescens YP 773876.1|Burkholderia ambifaria AMMD

99

79

YP 006524544.1|Pseudomonas stutzeri DSM 10701 YP 004974418.1|Azospirillum lipoferum 4B

99

YP 001925767.1|Methylobacterium populi BJ001 96

ZP 07026223.1|Afipia sp. 1NLS2 NP 766690.1|Bradyrhizobium japonicum USDA 110

99

ZP 11430248.1|Afipia broomeae ATCC 49717 ZP 07025699.1|Afipia sp. 1NLS2 ZP 12507142.1|Agrobacterium tumefaciens F2 95

0.2

YP 004302029.1|Polymorphum gilvum SL003B-26A1

YP 004534555.1|Novosphingobium sp. PP1Y ZP 09191027.1|Novosphingobium pentaromativorans US6-1 ZP 10872513.1|Sphingomonas sp. LH128

ML

ZP 10746713.1|Novosphingobium sp. AP12 ZP 01303560.1|Sphingomonas sp. SKA58 YP 004835198.1|Sphingobium sp. SYK-6 ZP 09909938.1|Sphingobium yanoikuyae XLDN2-5

96

ZP 10543427.1|Sphingobium sp. AP49 YP 616951.1|Sphingopyxis alaskensis YP 003544795.1|Sphingobium japonicum UT26S 61

YP 004552635.1|Sphingobium chlorophenolicum L-1 ZP 01864812.1|Erythrobacter sp. SD-21 YP 457100.1|Erythrobacter litoralis HTCC2594

77

ZP 01038678.1|Erythrobacter sp. NAP1 YP 498334.1|Novosphingobium aromaticivorans DSM 12444 ZP 08208528.1|Novosphingobium nitrogenifigens DSM 19370 ZP 06860883.1|Citromicrobium bathyomarinum JL354 100 96

ZP 08702876.1|Citromicrobium sp. JLT1363 ZP 09953370.1|Sphingomonas elodea ATCC 31461 ZP 09140887.1|Sphingomonas sp. KC8 ZP 10425207.1|Sphingomonas sp. PAMC 26617 ZP 10344556.1|Sphingomonas sp. PAMC 26605

98 68

ZP 10338744.1|Sphingomonas echinoides ATCC 14820

81

YP 757396.1|Maricaulis maris MCS10 YP 001411312.1|Parvibaculum lavamentivorans DS-1 100

ref|NC 009719.1| Parvibaculum lavamentivorans DS-1 chromosome complete genome

YP 184745.1|Laribacter hongkongensis ZP 10075793.1|Desulfovibrio sp. U5L ZP 08634810.1|Acidiphilium sp. PM YP 361515.1|Xanthomonas campestris pv. vesicatoria str. 85-10

92

ZP 08666646.1|Paracoccus sp. TRP 95 100

YP 001965992.1|Xanthomonas axonopodis pv. glycines ref|NC 010872.1| Xanthomonas axonopodis pv. glycines plasmid pAG1 complete sequence ZP 13085317.1|Xanthomonas axonopodis pv. malvacearum str. GSPB1386

100

ZP 06705664.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 YP 001776801.1|Methylobacterium radiotolerans JCM 2831 YP 003162880.1|Candidatus Accumulibacter phosphatis clade IIA str. UW-1

82

ZP 09995471.1|Acidithiobacillus thiooxidans ATCC 19377 ZP 09287307.1|Pseudomonas psychrotolerans L19 Raf p14

81

Rau p11 100

Plasmid Plasmid

ZP 08778844.1|Candidatus Odyssella thessalonicensis L13 YP 002961220.1|Methylobacterium extorquens AM1

93

YP 003071359.1|Methylobacterium extorquens DM4 100

YP 002966225.1|Methylobacterium extorquens AM1

ZP 07111127.1|Oscillatoria sp. PCC 6506 YP 001770187.1|Methylobacterium sp. 4-46 ZP 09875261.1|Phaeospirillum molischianum DSM 120 YP 068544.1|Yersinia pseudotuberculosis IP 32953 ZP 08390645.1|Sphingomonas sp. S17

67 76

ZP 11572143.1|Pseudomonas syringae pv. glycinea str. race 4

100

YP 004831088.1|Serratia marcescens YP 773876.1|Burkholderia ambifaria AMMD

100

63

YP 006524544.1|Pseudomonas stutzeri DSM 10701 YP 004974418.1|Azospirillum lipoferum 4B

84

ZP 11430248.1|Afipia broomeae ATCC 49717 60 89 98

ZP 07026223.1|Afipia sp. 1NLS2 NP 766690.1|Bradyrhizobium japonicum USDA 110 YP 001925767.1|Methylobacterium populi BJ001 ZP 07025699.1|Afipia sp. 1NLS2

81 87

0.2

ZP 12507142.1|Agrobacterium tumefaciens F2 YP 004302029.1|Polymorphum gilvum SL003B-26A1

Figure A94. Neighbor-joining (NJ) and maximum likelihood (ML) trees of plasmid partitioning protein ParA. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 06705355.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 99 ref|NC 009739.1| Pseudomonas aeruginosa plasmid pMATVIM-7 complete sequence 74

NJ

NP 942639.1|Xanthomonas citri CAI47014.1|Bordetella bronchiseptica

100

YP 413495.1|Nitrosospira multiformis ATCC 25196

94

YP 006909000.1|Bordetella parapertussis

60

ZP 10341745.1|Sphingomonas echinoides ATCC 14820

Plasmid

Reis1 p11

YP 002923616.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) ZP 16367226.1|Providencia alcalifaciens Dmel2

70 100

62

NP 783717.1|Yersinia enterocolitica YP 001393406.1|Yersinia pseudotuberculosis IP 31758

83 98

ZP 11965238.1|Escherichia coli 1.2741 ZP 06658957.1|Escherichia coli B185

100 90

ZP 13498875.1|Escherichia coli O157:H43 str. T22

YP 001919454.1|Methylobacterium populi BJ001 ZP 12694039.1|Hyphomicrobium denitrificans 1NES1

82

YP 003757152.1|Hyphomicrobium denitrificans ATCC 51888

93 100

YP 004676315.1|Hyphomicrobium sp. MC1 YP 066857.1|Desulfotalea psychrophila LSv54 ZP 18265287.1|Saprospira grandis DSM 2844

100

YP 005317227.1|Saprospira grandis str. Lewin YP 004302426.1|Polymorphum gilvum SL003B-26A1 100 ZP 06482561.1|Pseudomonas syringae pv. aesculi str. 2250 72

ZP 11566973.1|Pseudomonas syringae pv. glycinea str. B076 ZP 11566906.1|Pseudomonas syringae pv. glycinea str. B076 YP 001471715.1|Serratia proteamaculans 568

77

64

ZP 12050197.1|Escherichia coli 2.3916 ZP 08351651.1|Escherichia coli M605

100

NP 995441.1|Yersinia pestis biovar Microtus str. 91001

100 100

YP 003212720.1|Cronobacter turicensis z3032 YP 001440429.1|Cronobacter sakazakii ATCC BAA-894

YP 001170550.1|Rhodobacter sphaeroides ATCC 17025 ZP 09878440.1|Phaeospirillum molischianum DSM 120 ZP 11567005.1|Pseudomonas syringae pv. glycinea str. B076 ZP 10408258.1|Citrobacter sp. A1

100

YP 002265378.1|Aliivibrio salmonicida LFI1238

98 100

0.1

ZP 06157940.1|Photobacterium damselae subsp. damselae CIP 102761

ZP 06705355.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 11122 85

ML

ref|NC 009739.1| Pseudomonas aeruginosa plasmid pMATVIM-7 complete sequence NP 942639.1|Xanthomonas citri CAI47014.1|Bordetella bronchiseptica

100

YP 006909000.1|Bordetella parapertussis YP 413495.1|Nitrosospira multiformis ATCC 25196

74

Reis1 p11

Plasmid

ZP 10341745.1|Sphingomonas echinoides ATCC 14820 YP 002923616.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) YP 001393406.1|Yersinia pseudotuberculosis IP 31758 NP 783717.1|Yersinia enterocolitica

98

ZP 16367226.1|Providencia alcalifaciens Dmel2

78

ZP 06658957.1|Escherichia coli B185

96

ZP 11965238.1|Escherichia coli 1.2741

100

65

ZP 13498875.1|Escherichia coli O157:H43 str. T22 YP 001919454.1|Methylobacterium populi BJ001 YP 066857.1|Desulfotalea psychrophila LSv54 ZP 12694039.1|Hyphomicrobium denitrificans 1NES1 YP 003757152.1|Hyphomicrobium denitrificans ATCC 51888

85 100

YP 004676315.1|Hyphomicrobium sp. MC1 YP 001170550.1|Rhodobacter sphaeroides ATCC 17025 ZP 09878440.1|Phaeospirillum molischianum DSM 120 ZP 11567005.1|Pseudomonas syringae pv. glycinea str. B076 ZP 10408258.1|Citrobacter sp. A1

86

YP 002265378.1|Aliivibrio salmonicida LFI1238

84 100

ZP 06157940.1|Photobacterium damselae subsp. damselae CIP 102761

YP 004302426.1|Polymorphum gilvum SL003B-26A1 100

ZP 18265287.1|Saprospira grandis DSM 2844 YP 005317227.1|Saprospira grandis str. Lewin ZP 11566906.1|Pseudomonas syringae pv. glycinea str. B076 100 ZP 06482561.1|Pseudomonas syringae pv. aesculi str. 2250

ZP 11566973.1|Pseudomonas syringae pv. glycinea str. B076 YP 001471715.1|Serratia proteamaculans 568

73

ZP 12050197.1|Escherichia coli 2.3916 ZP 08351651.1|Escherichia coli M605

100 100

NP 995441.1|Yersinia pestis biovar Microtus str. 91001 100 YP 003212720.1|Cronobacter turicensis z3032

YP 001440429.1|Cronobacter sakazakii ATCC BAA-894

0.2

Figure A95. Neighbor-joining (NJ) and maximum likelihood (ML) trees of plasmid partitioning protein ParA. Bootstrap supports higher than or equal to 60% are shown on the branches. ZP 11728525.1|Salmonella enterica subsp. enterica serovar Montevideo str. CASC 09SCPH15965

69 68 100

NJ

ZP 13756229.1|Escherichia coli DEC8C ZP 11508912.1|Escherichia coli OK1180

100

ZP 14605606.1|Escherichia coli O111:H8 str. CVM9634 ZP 13862020.1|Escherichia coli DEC12A YP 002923878.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)

73 80

YP 454299.1|Sodalis glossinidius str. morsitans YP 004215779.1|Rahnella sp. Y9602 ZP 00518773.1|Crocosphaera watsonii WH 8501

92

YP 001144244.1|Aeromonas salmonicida subsp. salmonicida A449 YP 004537835.1|Thioalkalimicrobium cyclicum ALM1

73

YP 001840863.1|Acinetobacter baumannii ACICU

100

ZP 06070988.1|Acinetobacter lwoffii SH145 100

YP 001966353.1|Moraxella bovis Epp63

79

ZP 05619981.1|Enhydrobacter aerosaccus SK60 YP 004243332.1|Arthrobacter phenanthrenivorans Sphe3

88

YP 001220805.1|Clavibacter michiganensis subsp. michiganensis NCPPB 382

79

YP 004243414.1|Arthrobacter phenanthrenivorans Sphe3

90 100

YP 950167.1|Arthrobacter aurescens TC1 YP 006022880.1|Shewanella baltica BA175

YP 379033.1|Chlorobium chlorochromatii CaD3

85 87

ZP 08312488.1|Photobacterium leiognathi subsp. mandapamensis svers.1.1.

81

ZP 04617854.1|Yersinia ruckeri ATCC 29473 ZP 06641412.1|Serratia odorifera DSM 4582

100

ZP 06189156.1|Serratia odorifera 4Rx13

100 61

YP 001477609.1|Serratia proteamaculans 568

YP 003445117.1|Allochromatium vinosum DSM 180

86

YP 001670397.1|Pseudomonas putida GB-1 YP 001901321.1|Ralstonia pickettii 12J

69 100

YP 003747204.1|Ralstonia solanacearum PSI07 ZP 05826576.1|Acinetobacter sp.

100

ZP 05362210.1|Acinetobacter radioresistens SK82 YP 001094450.1|Shewanella loihica PV-4

100

YP 001760148.1|Shewanella woodyi ATCC 51908

100

YP 001474614.1|Shewanella sediminis HAW-EB3

92

YP 003556333.1|Shewanella violacea DSS12 77 65 100 100

ZP 02156947.1|Shewanella benthica KT99

ZP 07400676.1|Campylobacter coli JV20 ZP 14195693.1|Campylobacter jejuni subsp. jejuni 1997-7 ZP 04807998.1|Helicobacter pullorum MIT 98-5489 YP 001456648.1|Campylobacter concisus 13826

86

NP 907298.1|Wolinella succinogenes DSM 1740 ZP 18246598.1|Campylobacter fetus subsp. venerealis NCTC 10354 YP 002576129.1|Campylobacter lari 100

ZP 18209949.1|Campylobacter showae CSUNSWCD

95 100

ZP 03609888.1|Campylobacter rectus

ZP 04581456.1|Helicobacter bilis ATCC 43879 ZP 04580212.1|Helicobacter bilis ATCC 43879

Pla smid

Rra3 p28

96

ZP 08778927.1|Candidatus Odyssella thessalonicensis L13 ZP 03335657.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB ZP 09865655.1|Methylomicrobium album BG8 96

YP 003522601.1|Nitrosococcus halophilus Nc4 YP 001953903.1|Geobacter lovleyi SZ

61

YP 004451327.1|Haliscomenobacter hydrossis DSM 1100 99

65

100

ZP 09910204.1|Sphingobium yanoikuyae XLDN2-5 ZP 08389807.1|Sphingomonas sp. S17 YP 006965807.1|Sphingobium fuliginis ATCC 27551

97

YP 425037.1|Rhodospirillum rubrum ATCC 11170 ZP 09972784.1|Serratia sp. M24T3 89

ZP 10101490.1|Thiothrix nivea DSM 5205 YP 002364203.1|Thauera sp. MZ1T 90

YP 003624521.1|Thiomonas sp. 3As ZP 18293288.1|Leptospirillum sp. Group II C75 98

ZP 11377384.1|Gluconobacter frateurii NBRC 101659 69

YP 257082.1|Sodalis glossinidius ZP 06733062.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535 YP 001220338.1|Acidiphilium cryptum JF-5

0.1

ML

YP 001840863.1|Acinetobacter baumannii ACICU

96

ZP 06070988.1|Acinetobacter lwoffii SH145

99

YP 001966353.1|Moraxella bovis Epp63 91

ZP 05619981.1|Enhydrobacter aerosaccus SK60 YP 004243332.1|Arthrobacter phenanthrenivorans Sphe3 YP 001220805.1|Clavibacter michiganensis subsp. michiganensis NCPPB 382 YP 004243414.1|Arthrobacter phenanthrenivorans Sphe3

81 99

YP 950167.1|Arthrobacter aurescens TC1

YP 379033.1|Chlorobium chlorochromatii CaD3 ZP 08312488.1|Photobacterium leiognathi subsp. mandapamensis svers.1.1. YP 006022880.1|Shewanella baltica BA175

64

ZP 04617854.1|Yersinia ruckeri ATCC 29473

69

YP 001477609.1|Serratia proteamaculans 568

99

ZP 06641412.1|Serratia odorifera DSM 4582

95

ZP 06189156.1|Serratia odorifera 4Rx13 YP 004537835.1|Thioalkalimicrobium cyclicum ALM1 YP 001144244.1|Aeromonas salmonicida subsp. salmonicida A449 80

YP 002923878.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)

80

YP 454299.1|Sodalis glossinidius str. morsitans YP 004215779.1|Rahnella sp. Y9602 ZP 00518773.1|Crocosphaera watsonii WH 8501 ZP 13862020.1|Escherichia coli DEC12A ZP 13756229.1|Escherichia coli DEC8C 98

ZP 14605606.1|Escherichia coli O111:H8 str. CVM9634 99 ZP 11728525.1|Salmonella enterica subsp. enterica serovar Montevideo str. CASC 09SCPH15965

ZP 11508912.1|Escherichia coli OK1180 ZP 05826576.1|Acinetobacter sp.

97

ZP 05362210.1|Acinetobacter radioresistens SK82 YP 001760148.1|Shewanella woodyi ATCC 51908

97

YP 003556333.1|Shewanella violacea DSS12

85 99

ZP 02156947.1|Shewanella benthica KT99 YP 001094450.1|Shewanella loihica PV-4 YP 001474614.1|Shewanella sediminis HAW-EB3

YP 003445117.1|Allochromatium vinosum DSM 180 YP 001901321.1|Ralstonia pickettii 12J 99

YP 003747204.1|Ralstonia solanacearum PSI07 YP 001670397.1|Pseudomonas putida GB-1 ZP 06733062.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535

79

YP 257082.1|Sodalis glossinidius 94

YP 001220338.1|Acidiphilium cryptum JF-5 ZP 11377384.1|Gluconobacter frateurii NBRC 101659 ZP 10101490.1|Thiothrix nivea DSM 5205 YP 003624521.1|Thiomonas sp. 3As

63

ZP 18293288.1|Leptospirillum sp. Group II C75 99

YP 002364203.1|Thauera sp. MZ1T ZP 09972784.1|Serratia sp. M24T3 YP 425037.1|Rhodospirillum rubrum ATCC 11170

67

YP 006965807.1|Sphingobium fuliginis ATCC 27551 97

97 80

84

ZP 09910204.1|Sphingobium yanoikuyae XLDN2-5 ZP 08389807.1|Sphingomonas sp. S17 YP 004451327.1|Haliscomenobacter hydrossis DSM 1100

YP 001953903.1|Geobacter lovleyi SZ Rra3 p28

82

Plasmid

ZP 08778927.1|Candidatus Odyssella thessalonicensis L13

73

ZP 03335657.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB ZP 09865655.1|Methylomicrobium album BG8 YP 003522601.1|Nitrosococcus halophilus Nc4 ZP 04580212.1|Helicobacter bilis ATCC 43879 ZP 04581456.1|Helicobacter bilis ATCC 43879 99

99 96

ZP 18209949.1|Campylobacter showae CSUNSWCD ZP 03609888.1|Campylobacter rectus

YP 002576129.1|Campylobacter lari ZP 18246598.1|Campylobacter fetus subsp. venerealis NCTC 10354 NP 907298.1|Wolinella succinogenes DSM 1740 YP 001456648.1|Campylobacter concisus 13826

70

ZP 14195693.1|Campylobacter jejuni subsp. jejuni 1997-7

97 99

ZP 07400676.1|Campylobacter coli JV20 ZP 04807998.1|Helicobacter pullorum MIT 98-5489

0.2

Figure A96. Neighbor-joining (NJ) and maximum likelihood (ML) trees of plasmid partitioning protein ParA. Bootstrap supports higher than or equal to 60% are shown on the branches. YP 006966083.1|Pasteurella multocida

91 99

NJ

YP 245407.1|Actinobacillus porcitonsillarum YP 245399.1|Actinobacillus porcitonsillarum

62

YP 005202442.1|Rahnella aquatilis CIP 78.65 ATCC 33071 94

YP 002923962.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) ZP 08149266.1|Haemophilus parainfluenzae ATCC 33392 NP 940697.1|Pseudomonas syringae pv. syringae 99

YP 006963279.1|Pseudomonas syringae

WP 018417334.1|Teredinibacter turnerae ZP 08040538.1|Serratia symbiotica str. Tucson 69

99

ZP 06641741.1|Serratia odorifera DSM 4582 ZP 12963802.1|Aeromonas salmonicida subsp. salmonicida 01-B526 YP 006954371.1|Escherichia coli

99 99

ZP 06015381.1|Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884 Rpe p03

Pla smids

Rfe p31

99

RfeI1 p32-33

99

YP 001220805.1|Clavibacter michiganensis subsp. michiganensis NCPPB 382 YP 950167.1|Arthrobacter aurescens TC1

93 99

YP 004243414.1|Arthrobacter phenanthrenivorans Sphe3 ZP 01899391.1|Moritella sp. PE36

ZP 06070988.1|Acinetobacter lwoffii SH145

99

YP 001840863.1|Acinetobacter baumannii ACICU

99

ZP 05619981.1|Enhydrobacter aerosaccus SK60 74

YP 001966353.1|Moraxella bovis Epp63

64

YP 004537835.1|Thioalkalimicrobium cyclicum ALM1

99

ZP 08932679.1|Thioalkalimicrobium aerophilum AL3 ZP 00518773.1|Crocosphaera watsonii WH 8501

84

YP 001144244.1|Aeromonas salmonicida subsp. salmonicida A449 YP 002923878.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)

78 61

YP 454299.1|Sodalis glossinidius str. morsitans YP 004215779.1|Rahnella sp. Y9602 ZP 13862020.1|Escherichia coli DEC12A

75

ZP 11728525.1|Salmonella enterica subsp. enterica serovar Montevideo str. CASC 09SCPH15965

99 99

ZP 11508912.1|Escherichia coli OK1180 ZP 14605606.1|Escherichia coli O111:H8 str. CVM9634 YP 005525942.1|Acinetobacter baumannii MDR-ZJ06

99

ZP 05618999.1|Enhydrobacter aerosaccus SK60

99

ZP 06064525.1|Acinetobacter johnsonii SH046 99

ZP 06725885.1|Acinetobacter haemolyticus ATCC 19194 ZP 08745477.1|Vibrio ichthyoenteri ATCC 700023

99

ZP 06157790.1|Photobacterium damselae subsp. damselae CIP 102761 YP 006022880.1|Shewanella baltica BA175 ZP 08312488.1|Photobacterium leiognathi subsp. mandapamensis svers.1.1.

88

YP 379033.1|Chlorobium chlorochromatii CaD3 99 75

YP 001477609.1|Serratia proteamaculans 568 ZP 06189156.1|Serratia odorifera 4Rx13 ZP 04617854.1|Yersinia ruckeri ATCC 29473 YP 004118824.1|Pantoea sp. At-9b

99

YP 003540595.1|Erwinia amylovora ATCC 49946 99 75 95

YP 004954419.1|Enterobacter cloacae EcWSU1 ZP 12963831.1|Aeromonas salmonicida subsp. salmonicida 01-B526

80 75 68 85

ZP 09513953.1|Pantoea sp. SL1 M5 YP 003517444.1|Klebsiella pneumoniae ZP 17094358.1|Klebsiella oxytoca 10-5242 ZP 14413488.1|Escherichia coli O111:H8 str. CVM9574 YP 006957481.1|Salmonella enterica subsp. salamae ZP 12047191.1|Escherichia coli 2.3916 YP 002756647.1|Escherichia coli ZP 07678236.1|Shigella dysenteriae 1617 99

YP 003556333.1|Shewanella violacea DSS12 YP 001760148.1|Shewanella woodyi ATCC 51908

ZP 11331512.1|Glaciecola polaris LMG 21857 ZP 08778927.1|Candidatus Odyssella thessalonicensis L13

94

YP 001953903.1|Geobacter lovleyi SZ YP 003445117.1|Allochromatium vinosum DSM 180 YP 001670397.1|Pseudomonas putida GB-1 YP 003747204.1|Ralstonia solanacearum PSI07 99

YP 001901321.1|Ralstonia pickettii 12J YP 004243332.1|Arthrobacter phenanthrenivorans Sphe3

88

NP 776229.1|Corynebacterium glutamicum YP 001595672.1|Vibrio sp. 0908 NP 936926.1|Vibrio vulnificus YJ016

0.1

YP 002756647.1|Escherichia coli ZP 14413488.1|Escherichia coli O111:H8 str. CVM9574 ZP 07678236.1|Shigella dysenteriae 1617 ZP 12047191.1|Escherichia coli 2.3916 YP 006957481.1|Salmonella enterica subsp. salamae

ML

YP 003517444.1|Klebsiella pneumoniae 95

ZP 17094358.1|Klebsiella oxytoca 10-5242 ZP 09513953.1|Pantoea sp. SL1 M5 YP 004954419.1|Enterobacter cloacae EcWSU1

60 99

72

ZP 12963831.1|Aeromonas salmonicida subsp. salmonicida 01-B526 YP 003540595.1|Erwinia amylovora ATCC 49946

97

YP 004118824.1|Pantoea sp. At-9b ZP 04617854.1|Yersinia ruckeri ATCC 29473 YP 001477609.1|Serratia proteamaculans 568

81 99

ZP 06189156.1|Serratia odorifera 4Rx13 YP 006022880.1|Shewanella baltica BA175

ZP 08312488.1|Photobacterium leiognathi subsp. mandapamensis svers.1.1. 61

YP 379033.1|Chlorobium chlorochromatii CaD3 ZP 11331512.1|Glaciecola polaris LMG 21857 YP 004243332.1|Arthrobacter phenanthrenivorans Sphe3 84 96

NP 776229.1|Corynebacterium glutamicum ZP 06070988.1|Acinetobacter lwoffii SH145 YP 001840863.1|Acinetobacter baumannii ACICU

98

ZP 05619981.1|Enhydrobacter aerosaccus SK60 70

YP 001966353.1|Moraxella bovis Epp63 ZP 01899391.1|Moritella sp. PE36 YP 004537835.1|Thioalkalimicrobium cyclicum ALM1

99

ZP 08932679.1|Thioalkalimicrobium aerophilum AL3 YP 001144244.1|Aeromonas salmonicida subsp. salmonicida A449

71

ZP 00518773.1|Crocosphaera watsonii WH 8501 YP 002923878.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)

65

YP 454299.1|Sodalis glossinidius str. morsitans YP 004215779.1|Rahnella sp. Y9602 ZP 13862020.1|Escherichia coli DEC12A ZP 11728525.1|Salmonella enterica subsp. enterica serovar Montevideo str. CASC 09SCPH15965

98

ZP 11508912.1|Escherichia coli OK1180

99

71 ZP 14605606.1|Escherichia coli O111:H8 str. CVM9634

YP 003747204.1|Ralstonia solanacearum PSI07

99

YP 001901321.1|Ralstonia pickettii 12J YP 001670397.1|Pseudomonas putida GB-1 YP 003445117.1|Allochromatium vinosum DSM 180 ZP 08778927.1|Candidatus Odyssella thessalonicensis L13 94

YP 001953903.1|Geobacter lovleyi SZ YP 003556333.1|Shewanella violacea DSS12 99

YP 001760148.1|Shewanella woodyi ATCC 51908

YP 001595672.1|Vibrio sp. 0908 ZP 08745477.1|Vibrio ichthyoenteri ATCC 700023

99

ZP 06157790.1|Photobacterium damselae subsp. damselae CIP 102761 NP 936926.1|Vibrio vulnificus YJ016 YP 005525942.1|Acinetobacter baumannii MDR-ZJ06

98

ZP 05618999.1|Enhydrobacter aerosaccus SK60 98

ZP 06064525.1|Acinetobacter johnsonii SH046 97

ZP 06725885.1|Acinetobacter haemolyticus ATCC 19194

WP 018417334.1|Teredinibacter turnerae NP 940697.1|Pseudomonas syringae pv. syringae

99

72

YP 006963279.1|Pseudomonas syringae ZP 08149266.1|Haemophilus parainfluenzae ATCC 33392 85 99

YP 006966083.1|Pasteurella multocida YP 245407.1|Actinobacillus porcitonsillarum YP 245399.1|Actinobacillus porcitonsillarum YP 005202442.1|Rahnella aquatilis CIP 78.65 ATCC 33071 YP 002923962.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum)

99 99

ZP 08040538.1|Serratia symbiotica str. Tucson ZP 06641741.1|Serratia odorifera DSM 4582 ZP 12963802.1|Aeromonas salmonicida subsp. salmonicida 01-B526 YP 006954371.1|Escherichia coli 99

99

Rfe p31 RfeI1 p32-33

99

ZP 06015381.1|Klebsiella pneumoniae subsp. rhinoscleromatis ATCC 13884

Pla smids

Rpe p03 99

YP 950167.1|Arthrobacter aurescens TC1 YP 004243414.1|Arthrobacter phenanthrenivorans Sphe3

75

0.2

YP 001220805.1|Clavibacter michiganensis subsp. michiganensis NCPPB 382

Figure A97. Neighbor-joining (NJ) and maximum likelihood (ML) trees of plasmid partitioning protein ParA. Bootstrap supports higher than or equal to 60% are shown on the branches. YP 004124909.1|Alicycliphilus denitrificans BC YP 002554949.1|Acidovorax ebreus TPSY YP 001630795.1|Bordetella petrii DSM 12804 YP 002513947.1|Thioalkalivibrio sulfidophilus HL-EbGr7 YP 583409.1|Cupriavidus metallidurans CH34 ZP 11915994.1|Pseudomonas aeruginosa 138244 67

YP 004387498.1|Alicycliphilus denitrificans K601 YP 583638.1|Cupriavidus metallidurans CH34 YP 006292802.1|Methylophaga sp. JAM7

NJ

YP 001561488.1|Delftia acidovorans SPH-1 YP 001971173.1|Stenotrophomonas maltophilia K279a YP 773876.1|Burkholderia ambifaria AMMD ZP 10762969.1|Pseudomonas pseudoalcaligenes CECT 5344

61

ZP 03826533.1|Pectobacterium carotovorum subsp. brasiliensis PBR1692 NP 520726.1|Ralstonia solanacearum GMI1000

87

ZP 04558905.1|Citrobacter sp. 30 2 YP 006531346.1|Pseudomonas putida DOT-T1E YP 969062.1|Acidovorax citrulli AAC00-1 ZP 16327765.1|Ralstonia solanacearum MolK2 ZP 03573796.1|Burkholderia multivorans CGD2M ZP 13088779.1|Xanthomonas axonopodis pv. malvacearum str. GSPB2388 YP 006183646.1|Stenotrophomonas maltophilia D457

95 99

YP 002800719.1|Azotobacter vinelandii DJ ZP 10203785.1|Rhodanobacter thiooxydans LCS2

73

ZP 10154940.1|Hydrogenophaga sp. PBC

99

YP 001188916.1|Pseudomonas mendocina ymp YP 674889.1|Chelativorans sp. BNC1 ZP 11430248.1|Afipia broomeae ATCC 49717 ZP 07026223.1|Afipia sp. 1NLS2

99

YP 001417764.1|Xanthobacter autotrophicus Py2 ZP 10587664.1|Phyllobacterium sp. YR531 ZP 09295715.1|Mesorhizobium alhagi CCNW XJ12-2

99

YP 003547162.1|Sphingobium japonicum UT26S YP 004302029.1|Polymorphum gilvum SL003B-26A1 YP 002287024.1|Oligotropha carboxidovorans OM5 99

YP 001526749.1|Azorhizobium caulinodans ORS 571 YP 001415495.1|Xanthobacter autotrophicus Py2 YP 003545455.1|Sphingobium japonicum UT26S YP 003944227.1|Ketogulonicigenium vulgare Y25 ZP 09906868.1|Sphingobium yanoikuyae XLDN2-5

99

ZP 11155920.1|Nitratireductor indicus C115 YP 579024.1|Nitrobacter hamburgensis X14 YP 114757.1|Methylococcus capsulatus str. Bath ZP 07110550.1|Oscillatoria sp. PCC 6506 NP 052163.1|Chlorobium limicola YP 001869858.1|Nostoc punctiforme PCC 73102 97

Rma p19 70 84 99 99

RmaB p02 Rra1 p21

Pla smids

Rrh p19 Ram18 p08 XP 002118475.1|Trichoplax adhaerens

YP 004831088.1|Serratia marcescens 94

YP 002924855.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) ZP 08390645.1|Sphingomonas sp. S17 ZP 11572143.1|Pseudomonas syringae pv. glycinea str. race 4

98

YP 001220602.1|Aeromonas bestiarum 86

YP 005418072.1|Rhodospirillum photometricum DSM 122

64

YP 004750507.1|Acidithiobacillus caldus SM-1 86

NP 644727.1|Xanthomonas axonopodis pv. citri str. 306 YP 004277303.1|Acidiphilium multivorum AIU301 YP 973970.1|Polaromonas naphthalenivorans CJ2

81

ZP 10468173.1|Bartonella birtlesii LL-W M9 ZP 10459983.1|Bartonella washoensis 085-0475

99

YP 034046.1|Bartonella henselae str. Houston-1 YP 001609992.1|Bartonella tribocorum CIP 105476 ZP 10459844.1|Bartonella elizabethae

93 61

YP 002972351.1|Bartonella grahamii as4aup

ZP 07661906.1|Roseibium sp. TrichSKD4 ZP 11250855.1|Acidocella sp. MX-AZ02 90

YP 426613.1|Rhodospirillum rubrum ATCC 11170 ZP 11128951.1|Oceanibaculum indicum P24 ZP 09875261.1|Phaeospirillum molischianum DSM 120

86

gi|144898517|emb|CAM75381.1|Magnetospirillum gryphiswaldense MSR-1

98

ZP 00054649.1|Magnetospirillum magnetotacticum MS-1

99 95

YP 420668.1|Magnetospirillum magneticum AMB-1 Rhe p58 99 62

99

Ram32 p15

Pla smids

Rra2 p042

ZP 10749010.1|Caulobacter sp. AP07 YP 001752075.1|Methylobacterium radiotolerans JCM 2831

75

ZP 02186915.1|alpha proteobacterium BAL199 91

97

YP 001522097.1|Acaryochloris marina MBIC11017 Ram23 p33

0.2

Pla smid

YP 004124909.1|Alicycliphilus denitrificans BC YP 001630795.1|Bordetella petrii DSM 12804 YP 006292802.1|Methylophaga sp. JAM7 YP 583409.1|Cupriavidus metallidurans CH34 64

YP 002554949.1|Acidovorax ebreus TPSY YP 583638.1|Cupriavidus metallidurans CH34 ZP 16327765.1|Ralstonia solanacearum MolK2 ZP 11915994.1|Pseudomonas aeruginosa 138244

ML

YP 004387498.1|Alicycliphilus denitrificans K601 YP 001561488.1|Delftia acidovorans SPH-1 YP 002513947.1|Thioalkalivibrio sulfidophilus HL-EbGr7 YP 001971173.1|Stenotrophomonas maltophilia K279a ZP 10762969.1|Pseudomonas pseudoalcaligenes CECT 5344 ZP 03826533.1|Pectobacterium carotovorum subsp. brasiliensis PBR1692 NP 520726.1|Ralstonia solanacearum GMI1000 ZP 04558905.1|Citrobacter sp. 30 2 YP 006531346.1|Pseudomonas putida DOT-T1E YP 969062.1|Acidovorax citrulli AAC00-1 ZP 03573796.1|Burkholderia multivorans CGD2M

64

YP 002800719.1|Azotobacter vinelandii DJ ZP 13088779.1|Xanthomonas axonopodis pv. malvacearum str. GSPB2388

98

YP 006183646.1|Stenotrophomonas maltophilia D457 YP 773876.1|Burkholderia ambifaria AMMD 100

ZP 10203785.1|Rhodanobacter thiooxydans LCS2 ZP 10154940.1|Hydrogenophaga sp. PBC

92

YP 001188916.1|Pseudomonas mendocina ymp ZP 07026223.1|Afipia sp. 1NLS2 ZP 11430248.1|Afipia broomeae ATCC 49717 97

ZP 10587664.1|Phyllobacterium sp. YR531 YP 001417764.1|Xanthobacter autotrophicus Py2 YP 001526749.1|Azorhizobium caulinodans ORS 571 YP 001415495.1|Xanthobacter autotrophicus Py2 YP 003545455.1|Sphingobium japonicum UT26S YP 674889.1|Chelativorans sp. BNC1 ZP 09295715.1|Mesorhizobium alhagi CCNWXJ12-2

100

YP 003547162.1|Sphingobium japonicum UT26S 93

YP 004302029.1|Polymorphum gilvum SL003B-26A1 YP 002287024.1|Oligotropha carboxidovorans OM5 YP 003944227.1|Ketogulonicigenium vulgare Y25 ZP 09906868.1|Sphingobium yanoikuyae XLDN2-5

98 66

ZP 11155920.1|Nitratireductor indicus C115

YP 579024.1|Nitrobacter hamburgensis X14

60

YP 114757.1|Methylococcus capsulatus str. Bath Rra1 p21 70 100

Rma p19

Pla smids

Rrh p19 RmaB p02

100

62

Ram18 p08 XP 002118475.1|Trichoplax adhaerens NP 052163.1|Chlorobium limicola ZP 07110550.1|Oscillatoria sp. PCC 6506 YP 001869858.1|Nostoc punctiforme PCC 73102

62

YP 004831088.1|Serratia marcescens

85

YP 002924855.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) ZP 11572143.1|Pseudomonas syringae pv. glycinea str. race 4

65

YP 001220602.1|Aeromonas bestiarum YP 004277303.1|Acidiphilium multivorum AIU301 YP 973970.1|Polaromonas naphthalenivorans CJ2

98

YP 005418072.1|Rhodospirillum photometricum DSM 122 YP 004750507.1|Acidithiobacillus caldus SM-1

84

NP 644727.1|Xanthomonas axonopodis pv. citri str. 306 ZP 08390645.1|Sphingomonas sp. S17 ZP 10459983.1|Bartonella washoensis 085-0475 ZP 10468173.1|Bartonella birtlesii LL-WM9

100

YP 034046.1|Bartonella henselae str. Houston-1 ZP 10459844.1|Bartonella elizabethae 97 60

YP 002972351.1|Bartonella grahamii as4aup YP 001609992.1|Bartonella tribocorum CIP 105476

ZP 07661906.1|Roseibium sp. TrichSKD4 ZP 11250855.1|Acidocella sp. MX-AZ02

92

YP 426613.1|Rhodospirillum rubrum ATCC 11170 ZP 11128951.1|Oceanibaculum indicum P24

73

ZP 09875261.1|Phaeospirillum molischianum DSM 120 gi|144898517|emb|CAM75381.1|Magnetospirillum gryphiswaldense MSR-1

100

ZP 00054649.1|Magnetospirillum magnetotacticum MS-1

95 83

YP 420668.1|Magnetospirillum magneticum AMB-1

Ram32 p15 Rra2 p042 100

Pla smids

Rhe p58 100

ZP 10749010.1|Caulobacter sp. AP07 YP 001752075.1|Methylobacterium radiotolerans JCM 2831

100

73

ZP 02186915.1|alpha proteobacterium BAL199 YP 001522097.1|Acaryochloris marina MBIC11017 Ram23 p33

0.2

Pla smid

Figure A98. Neighbor-joining (NJ) and maximum likelihood (ML) trees of plasmid partitioning protein ParA. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

100

ZP 04292359.1|Bacillus cereus ZP 04154099.1|Bacillus pseudomycoides DSM 12442 ZP 10969470.1|Sporolactobacillus vineae DSM 21990 SL153

99

ZP 10208937.1|Planococcus antarcticus DSM 14505 81

ZP 10910286.1|Oceanobacillus sp. Ndiop ZP 09100853.1|Desulfotomaculum gibsoniae DSM 7213 YP 003853273.1|Thermoanaerobacterium thermosaccharolyticum DSM 571

100

ZP 08211932.1|Thermoanaerobacter ethanolicus JW 200 ZP 15536144.1|Pelosinus fermentans JBW45 YP 001038772.1|Clostridium thermocellum ATCC 27405

69 100

ZP 09463391.1|Acetivibrio cellulolyticus CD2 YP 006911984.1|Dehalobacter sp. DCA

100

ZP 17064618.1|Desulfitobacterium hafniense DP7 ZP 04446528.1|Collinsella intestinalis DSM 13280 ZP 07664804.1|Atopobium vaginae DSM 15829

100 98

YP 003800016.1|Olsenella uli DSM 7084 ZP 05427697.1|Eubacterium saphenum ATCC 49989

73

YP 003996141.1|Halanaerobium hydrogeniformans 100

ZP 11018965.1|Clostridiales bacterium OBRC5-5 ZP 10830401.1|Lachnospiraceae bacterium ICM7

ZP 02438928.1|Clostridium sp. SS2/1

99

ZP 03717543.1|Eubacterium hallii DSM 3353

74

ZP 03801651.1|Coprococcus comes ATCC 27758

98 99

91

72

ZP 08336020.1|Lachnospiraceae bacterium 9 1 43BFAA ZP 03167317.1|Ruminococcus lactaris ATCC 29176

83

YP 002931486.1|Eubacterium eligens ATCC 27750

99

ZP 03463166.1|Bacteroides pectinophilus ATCC 43243 ZP 03784246.1|Blautia hydrogenotrophica DSM 10507

100

ZP 05854744.1|Blautia hansenii DSM 20583

80 100 100

ZP 08332618.1|Lachnospiraceae bacterium 6 1 63FAA ZP 09729865.1|Thermococcus litoralis DSM 5473 YP 004759706.1|Corynebacterium variabile DSM 44702

100

NP 600639.1|Corynebacterium glutamicum ATCC 13032

YP 003968911.1|Ilyobacter polytropus DSM 2926 Rfe pd07 99 100 62

RfeI1 p07

Plasmids

Rfe p07 Reis2 p34 Reis3 p14 100

ZP 01869210.1|Vibrio shilonii AK1 YP 001436094.1|Vibrio harveyi ATCC BAA-1116 ZP 10489138.1|Enterobacter radicincitans DSM 16656

91

NP 720345.2|Shewanella oneidensis MR-1

71 97

0.1

YP 001144337.1|Aeromonas salmonicida subsp. salmonicida A449

100 ZP 04292359.1|Bacillus cereus

ML

59

ZP 04154099.1|Bacillus pseudomycoides DSM 12442 ZP 10969470.1|Sporolactobacillus vineae DSM 21990 SL153

97

ZP 10208937.1|Planococcus antarcticus DSM 14505 33

66

ZP 10910286.1|Oceanobacillus sp. Ndiop ZP 15536144.1|Pelosinus fermentans JBW45

21

YP 001038772.1|Clostridium thermocellum ATCC 27405

40 100

ZP 09463391.1|Acetivibrio cellulolyticus CD2

14

ZP 09100853.1|Desulfotomaculum gibsoniae DSM 7213 YP 006911984.1|Dehalobacter sp. DCA

20 100

ZP 17064618.1|Desulfitobacterium hafniense DP7

100

ZP 08211932.1|Thermoanaerobacter ethanolicus JW 200

YP 003853273.1|Thermoanaerobacterium thermosaccharolyticum DSM 571 9

ZP 05427697.1|Eubacterium saphenum ATCC 49989

37

YP 003996141.1|Halanaerobium hydrogeniformans ZP 04446528.1|Collinsella intestinalis DSM 13280

6 33

ZP 07664804.1|Atopobium vaginae DSM 15829

100 95

YP 003800016.1|Olsenella uli DSM 7084 100

ZP 11018965.1|Clostridiales bacterium OBRC5-5 ZP 10830401.1|Lachnospiraceae bacterium ICM7

YP 002931486.1|Eubacterium eligens ATCC 27750

94

ZP 03463166.1|Bacteroides pectinophilus ATCC 43243

76

100 ZP 05854744.1|Blautia hansenii DSM 20583 51

51

62

ZP 08332618.1|Lachnospiraceae bacterium 6 1 63FAA ZP 03784246.1|Blautia hydrogenotrophica DSM 10507 ZP 02438928.1|Clostridium sp. SS2/1

98

13

ZP 03717543.1|Eubacterium hallii DSM 3353 96

ZP 03167317.1|Ruminococcus lactaris ATCC 29176

20

ZP 03801651.1|Coprococcus comes ATCC 27758

99 99 100

ZP 08336020.1|Lachnospiraceae bacterium 9 1 43BFAA

ZP 09729865.1|Thermococcus litoralis DSM 5473 YP 004759706.1|Corynebacterium variabile DSM 44702 100

NP 600639.1|Corynebacterium glutamicum ATCC 13032

YP 003968911.1|Ilyobacter polytropus DSM 2926 Rfe pd07 82 100 89

RfeI1 p07

Plasmids

Rfe p07 Reis2 p34 Reis3 p14

ZP 10489138.1|Enterobacter radicincitans DSM 16656 NP 720345.2|Shewanella oneidensis MR-1

99 100

YP 001144337.1|Aeromonas salmonicida subsp. salmonicida A449 54

ZP 01869210.1|Vibrio shilonii AK1 100

0.2

YP 001436094.1|Vibrio harveyi ATCC BAA-1116

Figure A99. Neighbor-joining (NJ) and maximum likelihood (ML) trees of ParB-like nuclease domain-containing protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100 92

OtsBo1460 OtsIk0604

YP 180746.1|Ehrlichia ruminantium str. Welgevonden ZP 08777608.1|Candidatus Odyssella thessalonicensis L13 ZP 09187639.1|Halomonas boliviensis LC1 ZP 05643174.1|Staphylococcus aureus A9781

84 100

EHR99931.1|Staphylococcus epidermidis VCU129

99

ZP 07016621.1|Desulfonatronospira thiodismutans ASO3-1 NP 391979.1|Bacillus subtilis subsp. subtilis str. 168 100

ZP 07872078.1|Listeria marthii FSL S4-120 YP 003065651.1|Methylobacterium extorquens DM4 100 YP 002424276.1|Methylobacterium chloromethanicum CM4

ZP 09621844.1|Legionella drancourtii LLAP12

94 100

YP 122158.1|Legionella pneumophila str. Paris NP 052843.1|Coxiella burnetii 99 YP 001423437.1|Coxiella burnetii Dugway 5J108-111

100

NW 002145881.1|Hydra magnipapillata 100 Rfe p49 95

RfeI1 p50 72

ZP 08778755.1|Candidatus Odyssella thessalonicensis L13 99

0.2

Plasmids

ZP 08778936.1|Candidatus Odyssella thessalonicensis L13

100 OtsBo1460 70

OtsIk0604 YP 180746.1|Ehrlichia ruminantium str. Welgevonden

47

ML

ZP 08777608.1|Candidatus Odyssella thessalonicensis L13 24

60

ZP 09187639.1|Halomonas boliviensis LC1 ZP 05643174.1|Staphylococcus aureus A9781

82 100

EHR99931.1|Staphylococcus epidermidis VCU129

98

ZP 07016621.1|Desulfonatronospira thiodismutans ASO3-1 NP 391979.1|Bacillus subtilis subsp. subtilis str. 168 99

ZP 07872078.1|Listeria marthii FSL S4-120 YP 003065651.1|Methylobacterium extorquens DM4 100 YP 002424276.1|Methylobacterium chloromethanicum CM4 71

ZP 09621844.1|Legionella drancourtii LLAP12 YP 122158.1|Legionella pneumophila str. Paris

99

NP 052843.1|Coxiella burnetii 92 YP 001423437.1|Coxiella burnetii Dugway 5J108-111 99

NW 002145881.1|Hydra magnipapillata 100 88

RfeI1 p50 76

Plasmids

ZP 08778755.1|Candidatus Odyssella thessalonicensis L13 87

0.2

Rfe p49

ZP 08778936.1|Candidatus Odyssella thessalonicensis L13

Figure A100. Neighbor-joining (NJ) and maximum likelihood (ML) trees of resolvase protein containing HTH_7 domain. Bootstrap supports higher than or equal to 60% are shown on the branches. YP 001899048.1|Ralstonia pickettii 12J

93

YP 004129037.1|Alicycliphilus denitrificans BC YP 005028718.1|Dechlorosoma suillum PS ZP 11114152.1|Pseudomonas mandelii JR-1 65

NJ

ZP 08871488.1|Verminephrobacter aporrectodeae subsp. tuberculatae At4

99

YP 002924125.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) YP 005028686.1|Dechlorosoma suillum PS

YP 004049980.1|Sulfuricurvum kujiense DSM 16994

100

ZP 08778267.1|Candidatus Odyssella thessalonicensis L13 RprME0871

99

rpr22 CDS692

Pla smids

Rau p20 100

Ram32 p33 Reis4 p160134-13 YP 374762.1|Chlorobium luteolum DSM 273

93

YP 002019735.1|Prosthecochloris aestuarii DSM 271 ZP 08779034.1|Candidatus Odyssella thessalonicensis L13

100

ZP 01385144.1|Chlorobium ferrooxidans DSM 13031 YP 004662947.1|Simkania negevensis Z 77

YP 001678470.1|Francisella philomiragia subsp. philomiragia ATCC 25017 Rmo p12

Pla smids

Reis4 p160116

100

YP 005416742.1|Rhodospirillum photometricum DSM 122

60 99

ZP 09865664.1|Methylomicrobium album BG8 YP 005220729.1|Sinorhizobium fredii HH103 Raf p03

87 93 66

Rhe p54

83

Pla smids

Rra3 p20

87

Rra2 p025 ZP 10101512.1|Thiothrix nivea DSM 5205

63

90

ZP 10101504.1|Thiothrix nivea DSM 5205 100

AFK89167.1|Sulfitobacter sp. DFL14 64

ZP 05064943.1|Octadecabacter arcticus 238

YP 001393047.1|Vibrio vulnificus

99

ZP 09226214.1|Pseudoalteromonas sp. BSi20311 ZP 09504908.1|Alteromonas sp. S89 YP 004694722.1|Nitrosomonas sp. Is79A3 ZP 08778956.1|Candidatus Odyssella thessalonicensis L13

99

YP 001866745.1|Nostoc punctiforme PCC 73102 ZP 09251115.1|Acaryochloris sp. CCMEE 5410

60

87

ZP 05040388.1|Synechococcus sp. PCC 7335 NP 942423.1|Synechocystis sp. PCC 6803 YP 003761571.1|Nitrosococcus watsonii C-113

63

YP 007704685.1|Octadecabacter antarcticus 307 Rfe pd55 100

RfeI1 p90 Rfe p88

100 93

Ram18 p27

Pla smids

Rma p06 Rrh p07 Rra1 p15-16 RmaB p15

73 98 97

Rra1 p32 Rra2 p005 Rhe p37

Pla smids

Ram23 p12

98

Rfe p46 RfeI1 p47 98

YP 002015784.1|Prosthecochloris aestuarii DSM 271 ZP 08778819.1|Candidatus Odyssella thessalonicensis L13 88

NP 395220.1|Yersinia pestis CO92 ZP 09831225.1|Pantoea stewartii subsp. stewartii DC283 84

100

YP 002286998.1|Klebsiella pneumoniae YP 001693038.1|Yersinia enterocolitica

66

gi|404342427|gb|EJZ68811.1|Shigella flexneri 1485-80 ZP 09971762.1|Serratia sp. M24T3 NP 608306.1|Klebsiella pneumoniae 99 91

YP 247787.2|Haemophilus influenzae 86-028NP YP 003829051.1|Escherichia coli Reis1 p06

100

Pla smids

Rmo p37

98

ZP 08778295.1|Candidatus Odyssella thessalonicensis L13 84

80

ZP 08778669.1|Candidatus Odyssella thessalonicensis L13 ZP 10968825.1|Ochrobactrum anthropi CTS-325 YP 190400.1|Gluconobacter oxydans 621H

100

ZP 08527617.1|Agrobacterium sp. ATCC 31749

100 62

YP 665995.1|Mesorhizobium sp. BNC1 YP 440197.1|Burkholderia thailandensis E264 ZP 09620193.1|Legionella drancourtii LLAP12

68 86

YP 004783228.1|Acidithiobacillus ferrivorans SS3 ZP 06968598.1|Ktedonobacter racemifer DSM 44963 ZP 08779037.1|Candidatus Odyssella thessalonicensis L13 ZP 09619205.1|Legionella drancourtii LLAP12

99 100

Reis4_p160146

87

Reis2 p42 95

Pla smids

Reis2 p28 YP 002536059.1|Geobacter daltonii FRC-32

0.2

ZP 11114152.1|Pseudomonas mandelii JR-1 YP 002924125.1|Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) YP 005028718.1|Dechlorosoma suillum PS

ML

YP 001899048.1|Ralstonia pickettii 12J

60 88

YP 004129037.1|Alicycliphilus denitrificans BC

87

ZP 08871488.1|Verminephrobacter aporrectodeae subsp. tuberculatae At4 YP 005028686.1|Dechlorosoma suillum PS YP 004049980.1|Sulfuricurvum kujiense DSM 16994

99

ZP 08778267.1|Candidatus Odyssella thessalonicensis L13 Rau p20 84

Ram32 p33 99

Pla smids

Reis4 p160134-13 RprME0871 rpr22 CDS692

100

YP 005220729.1|Sinorhizobium fredii HH103 98

ZP 09865664.1|Methylomicrobium album BG8 YP 005416742.1|Rhodospirillum photometricum DSM 122 Rhe p54 80

86

Rra2 p025

99

Raf p03

64

Pla smids

Rra3 p20 ZP 10101512.1|Thiothrix nivea DSM 5205

87

95

ZP 10101504.1|Thiothrix nivea DSM 5205 98

gi|389596403|gb|AFK89167.1|Sulfitobacter sp. DFL14 95

94

ZP 05064943.1|Octadecabacter arcticus 238

YP 374762.1|Chlorobium luteolum DSM 273 YP 002019735.1|Prosthecochloris aestuarii DSM 271

64

ZP 01385144.1|Chlorobium ferrooxidans DSM 13031

87

ZP 08779034.1|Candidatus Odyssella thessalonicensis L13 Rmo p12

99

Reis4 p160116

Pla smids

YP 004662947.1|Simkania negevensis Z YP 001678470.1|Francisella philomiragia subsp. philomiragia ATCC 25017 YP 004694722.1|Nitrosomonas sp. Is79A3 YP 001393047.1|Vibrio vulnificus

100

ZP 09226214.1|Pseudoalteromonas sp. BSi20311 99

ZP 09504908.1|Alteromonas sp. S89 ZP 08778956.1|Candidatus Odyssella thessalonicensis L13 ZP 09251115.1|Acaryochloris sp. CCMEE 5410 ZP 05040388.1|Synechococcus sp. PCC 7335 NP 942423.1|Synechocystis sp. PCC 6803

79

YP 001866745.1|Nostoc punctiforme PCC 73102 YP 003761571.1|Nitrosococcus watsonii C-113 YP 007704685.1|Octadecabacter antarcticus 307 Rfe pd55 100

RfeI1 p90 Rfe p88 Ram18 p27

100

Pla smids

Rra1 p15-Rra1 p16 RmaB p15 Rma p06 76

Rrh p07 Rra1 p32

61 96

Rra2 p005

89

Rhe p37

98

Ram23 p12

Pla smids

Rfe p46 RfeI1 p47

89 97

YP 002015784.1|Prosthecochloris aestuarii DSM 271 ZP 08778819.1|Candidatus Odyssella thessalonicensis L13 gi|404342427|gb|EJZ68811.1|Shigella flexneri 1485-80 NP 395220.1|Yersinia pestis CO92 100 80

YP 002286998.1|Klebsiella pneumoniae YP 001693038.1|Yersinia enterocolitica ZP 09831225.1|Pantoea stewartii subsp. stewartii DC283 ZP 09971762.1|Serratia sp. M24T3

74

NP 608306.1|Klebsiella pneumoniae YP 247787.2|Haemophilus influenzae 86-028NP

87 85

YP 003829051.1|Escherichia coli YP 440197.1|Burkholderia thailandensis E264

100 93

Reis1 p06

Pla smids

Rmo p37

94

ZP 08778295.1|Candidatus Odyssella thessalonicensis L13 79

ZP 08778669.1|Candidatus Odyssella thessalonicensis L13 ZP 10968825.1|Ochrobactrum anthropi CTS-325

85

YP 665995.1|Mesorhizobium sp. BNC1 YP 190400.1|Gluconobacter oxydans 621H ZP 08527617.1|Agrobacterium sp. ATCC 31749 YP 002536059.1|Geobacter daltonii FRC-32 ZP 09620193.1|Legionella drancourtii LLAP12

85 78

YP 004783228.1|Acidithiobacillus ferrivorans SS3

99

ZP 06968598.1|Ktedonobacter racemifer DSM 44963 ZP 08779037.1|Candidatus Odyssella thessalonicensis L13 ZP 09619205.1|Legionella drancourtii LLAP12 Reis2 p42

96

Reis2 p28 97

Reis160146

0.2

Pla smids

Figure

A101.

Neighbor-joining

(NJ)

and

maximum

likelihood

(ML)

trees

of

transposase_IS240 / integrase containing rve domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 06108281.1|Brucella melitensis bv. 3 str. Ether

NJ

ZP 03786440.1|Brucella ceti str. Cudo

100

ZP 05822980.1|Brucella abortus NCTC 8038 100

NP 698831.1|Brucella suis 1330 YP 001373037.1|Ochrobactrum anthropi ATCC 49188 ZP 08666004.1|Paracoccus sp. TRP 98

YP 004277193.1|Acidiphilium multivorum AIU301 ZP 01036705.1|Roseovarius sp. 217

97

ZP 05068375.1|Octadecabacter arcticus 238

74 100

ZP 05068444.1|Octadecabacter arcticus 238 ZP 05050563.1|Octadecabacter antarcticus 307

100

100

ZP 05050457.1|Octadecabacter antarcticus 307 ZP 08863733.1|Ruegeria sp. TW15

100

ZP 08862218.1|Ruegeria sp. TW15 ZP 01036665.1|Roseovarius sp. 217 ZP 05102777.1|Roseobacter sp. GAI101

92

YP 002539538.1|Agrobacterium vitis S4 YP 002546314.1|Agrobacterium radiobacter K84

99 87

YP 001965583.1|Sinorhizobium meliloti YP 001975169.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel 99 97

YP 001976081.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel YP 001975160.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

Reis1 p50 Transposase/Integrase 62

100

Plasmid

YP 006705824.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006705256.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

97

YP 006706047.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006706026.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella

ZP 06890742.1|Methylosinus trichosporium OB3b 95 YP 001941680.1|Burkholderia multivorans ATCC 17616 93

YP 001585588.1|Burkholderia multivorans ATCC 17616 ZP 10250976.1|Burkholderia terrae BS001

100 96

ZP 10256343.1|Burkholderia terrae BS001 100

ZP 10030689.1|Burkholderia sp. Ch1-1 ZP 10156417.1|Hydrogenophaga sp. PBC

93

YP 003468505.1|Xenorhabdus bovienii SS-2004 ZP 04617966.1|Yersinia ruckeri ATCC 29473

100

YP 002424434.1|Yersinia pseudotuberculosis

75

ZP 09831111.1|Pantoea stewartii subsp. stewartii DC283 YP 003468284.1|Xenorhabdus bovienii SS-2004 79

0.1

YP 003712409.1|Xenorhabdus nematophila ATCC 19061

YP 002424434.1|Yersinia pseudotuberculosis

74 68

ML

ZP 09831111.1|Pantoea stewartii subsp. stewartii DC283 ZP 04617966.1|Yersinia ruckeri ATCC 29473

75

YP 003468284.1|Xenorhabdus bovienii SS-2004

100 99

YP 003712409.1|Xenorhabdus nematophila ATCC 19061

64

YP 003468505.1|Xenorhabdus bovienii SS-2004 65

ZP 10256343.1|Burkholderia terrae BS001

98

ZP 10156417.1|Hydrogenophaga sp. PBC ZP 06890742.1|Methylosinus trichosporium OB3b 100

YP 006705824.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella YP 006706047.1|Cardinium endosymbiont cEper1 of Encarsia pergandiella Reis1 p50

100

Plasmid

YP 001975160.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

89

100 YP 001975169.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

ZP 08863733.1|Ruegeria sp. TW15 ZP 05102777.1|Roseobacter sp. GAI101 ZP 01036665.1|Roseovarius sp. 217

88

YP 002546314.1|Agrobacterium radiobacter K84

100 100 100 73

73

YP 001965583.1|Sinorhizobium meliloti ZP 05068375.1|Octadecabacter arcticus 238 ZP 05068444.1|Octadecabacter arcticus 238 ZP 01036705.1|Roseovarius sp. 217

83

ZP 08666004.1|Paracoccus sp. TRP

87

YP 004277193.1|Acidiphilium multivorum AIU301 YP 001373037.1|Ochrobactrum anthropi ATCC 49188 100

ZP 06108281.1|Brucella melitensis bv. 3 str. Ether 100 NP 698831.1|Brucella suis 1330

0.1

Figure A102. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase mutator family, containing MULE domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ NP 116791.1|Microscilla sp. PRE1

99 79

ZP 11016915.1|Indibacter alkaliphilus LW1 YP 003583853.1|Zunongwangia profunda SM-A87

72

ZP 09482655.1|Anaerophaga sp. HS1 100

76

ZP 08846532.1|Anaerophaga thermohalophila DSM 12881 ZP 03967790.1|Sphingobacterium spiritivorum ATCC 33300

97

YP 006256984.1|Solitalea canadensis DSM 3403 ZP 09336864.1|Tannerella sp. 6 1 58FAA CT1

74

62

100 ZP 09197050.1|Prevotella stercorea DSM 18206 76 ZP 05546866.1|Parabacteroides sp. D13

ZP 09522544.1|Myroides odoratimimus CCUG 10230 ZP 09612110.1|Mucilaginibacter paludis DSM 18603

96

100 ZP 09612272.1|Mucilaginibacter paludis DSM 18603 100 ZP 03334416.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB 98

YP 001975293.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

73

NP 966061.1|Wolbachia endosymbiont of Drosophila melanogaster Rpe p27 99

78

Plasmid

ZP 09619429.1|Legionella drancourtii LLAP12 YP 006507906.1|Legionella pneumophila subsp. pneumophila

98

ZP 02061857.1|Rickettsiella grylli 96

ZP 02061792.1|Rickettsiella grylli ZP 08459786.1|Psychrobacter sp. 1501(2011)

YP 003892240.1|Sulfurimonas autotrophica DSM 16294

85 90

0.1

YP 006403671.1|Sulfurospirillum barnesii SES-3

NP 116791.1|Microscilla sp. PRE1

98

NJ

81

ZP 11016915.1|Indibacter alkaliphilus LW1 YP 003583853.1|Zunongwangia profunda SM-A87

69

ZP 09482655.1|Anaerophaga sp. HS1 100

79

ZP 08846532.1|Anaerophaga thermohalophila DSM 12881 ZP 03967790.1|Sphingobacterium spiritivorum ATCC 33300

78

YP 006256984.1|Solitalea canadensis DSM 3403 ZP 09336864.1|Tannerella sp. 6 1 58FAA CT1

66

81

100

ZP 09197050.1|Prevotella stercorea DSM 18206 ZP 05546866.1|Parabacteroides sp. D13 ZP 09522544.1|Myroides odoratimimus CCUG 10230

ZP 09612110.1|Mucilaginibacter paludis DSM 18603

99

100 ZP 09612272.1|Mucilaginibacter paludis DSM 18603

Rpe p27 92

Plasmid

100 ZP 03334416.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB

YP 001975293.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel 96

NP 966061.1|Wolbachia endosymbiont of Drosophila melanogaster

79

98

ZP 09619429.1|Legionella drancourtii LLAP12 YP 006507906.1|Legionella pneumophila subsp. pneumophila

99

ZP 02061857.1|Rickettsiella grylli 99

ZP 02061792.1|Rickettsiella grylli ZP 08459786.1|Psychrobacter sp. 1501(2011)

YP 003892240.1|Sulfurimonas autotrophica DSM 16294

93 85

0.1

YP 006403671.1|Sulfurospirillum barnesii SES-3

Figure A103. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing DUF4158 and DDE_Tn3 domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ ZP 10034960.1|Burkholderia sp. Ch1-1 100 ZP 10037313.1|Burkholderia sp. Ch1-1

YP 293614.1|Ralstonia eutropha JMP134 YP 025382.1|Ralstonia eutropha JMP134 YP 005028719.1|Dechlorosoma suillum PS 71

NP 943128.1|Pseudomonas putida ND6 100 YP 003617097.1|Pseudomonas putida

YP 002286831.1|Klebsiella pneumoniae 100 ZP 09883033.1|Xanthomonas citri pv. mangiferaeindicae LMG 941

YP 004888064.1|Xanthomonas arboricola pv. pruni str. CFBP 5530 99

YP 004129038.1|Alicycliphilus denitrificans BC 100 YP 001350671.1|Pseudomonas aeruginosa PA7 88 YP 001899047.1|Ralstonia pickettii 12J 100 YP 002360237.1|Shewanella baltica OS223

YP 002360306.1|Shewanella baltica OS223 100

ZP 06641759.1|Serratia odorifera DSM 4582 100

ZP 06157724.1|Photobacterium damselae subsp. damselae CIP 102761 ZP 09831234.1|Pantoea stewartii subsp. stewartii DC283

100

EHX95107.1|Escherichia coli DEC14D

65 100 100

gi|323943970|gb|EGB40057.1|Escherichia coli H120

ZP 10191148.1|Rhodanobacter sp. 115 YP 005028685.1|Dechlorosoma suillum PS YP 004783229.1|Acidithiobacillus ferrivorans SS3 ZP 09621098.1|Legionella drancourtii LLAP12 ZP 08779038.1|Candidatus Odyssella thessalonicensis L13 Reis2 p38-40

95

100 Reis4 p160018-19-141-43

0.1

Plasmids

YP 025382.1|Ralstonia eutropha JMP134 100 YP 293614.1|Ralstonia eutropha JMP134

ML

ZP 10037313.1|Burkholderia sp. Ch1-1 ZP 10034960.1|Burkholderia sp. Ch1-1 NP 943128.1|Pseudomonas putida ND6 100 YP 003617097.1|Pseudomonas putida

YP 002360237.1|Shewanella baltica OS223 100 YP 002360306.1|Shewanella baltica OS223

YP 005028719.1|Dechlorosoma suillum PS 100

ZP 09883033.1|Xanthomonas citri pv. mangiferaeindicae LMG 941 YP 004888064.1|Xanthomonas arboricola pv. pruni str. CFBP 5530

91

88

YP 004129038.1|Alicycliphilus denitrificans BC 100 YP 001350671.1|Pseudomonas aeruginosa PA7 81 YP 001899047.1|Ralstonia pickettii 12J

YP 002286831.1|Klebsiella pneumoniae ZP 06641759.1|Serratia odorifera DSM 4582 100

ZP 06157724.1|Photobacterium damselae subsp. damselae CIP 102761

100 79 100

ZP 09831234.1|Pantoea stewartii subsp. stewartii DC283 EHX95107.1|Escherichia coli DEC14D

92 100

100

gi|323943970|gb|EGB40057.1|Escherichia coli H120

ZP 10191148.1|Rhodanobacter sp. 115 YP 005028685.1|Dechlorosoma suillum PS YP 004783229.1|Acidithiobacillus ferrivorans SS3 ZP 09621098.1|Legionella drancourtii LLAP12 ZP 08779038.1|Candidatus Odyssella thessalonicensis L13 94

Reis2 p38-40 100 Reis4 p160018-19-141-43

0.1

Plasmids

Figure A104. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing DDE_IS66_C domain. Bootstrap supports higher than or equal to 60% are shown on the branches. NJ

76 YP 002295971.1|Escherichia coli SE11

ZP 06658970.1|Escherichia coli B185 ZP 03059212.1|Escherichia coli B171 100

YP 003364519.1|Citrobacter rodentium ICC168 ZP 06543387.1|Salmonella enterica subsp. enterica serovar Typhi str. E98-3139 Rfe p79 Rfe pd46 100

Plasmids

RfeI1 p79 99 gi|385363959|gb|EIF69707.1|Burkholderia pseudomallei 354e

ref|NC 006351.1| Burkholderia pseudomallei K96243 chromosome 2 82

ref|NC 017921.1| Burkholderia sp. KJ006 chromosome 2 YP 422683.1|Magnetospirillum magneticum AMB-1 YP 422688.1|Magnetospirillum magneticum AMB-1

0.1

ML ZP 06543387.1|Salmonella enterica subsp. enterica serovar Typhi str. E98-3139 100

ZP 03059212.1|Escherichia coli B171 YP 003364519.1|Citrobacter rodentium ICC168 YP 002295971.1|Escherichia coli SE11 65

ZP 06658970.1|Escherichia coli B185 Rfe pd46 Rfe p79

100

Plasmids

RfeI1 p79 YP 422688.1|Magnetospirillum magneticum AMB-1 YP 422683.1|Magnetospirillum magneticum AMB-1 82

ref|NC 017921.1| Burkholderia sp. KJ006 chromosome 2 gi|385363959|gb|EIF69707.1|Burkholderia pseudomallei 354e 100 ref|NC 006351.1| Burkholderia pseudomallei K96243 chromosome 2

0.1

Figure

A105.

Neighbor-joining

(NJ)

and

maximum

likelihood (ML)

trees

of

transposase/integrase containing HTH_28/32 and rve domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 07096791.1|Escherichia coli MS 107-1

97

NJ

100

ZP 08365469.1|Escherichia coli TA143 gi|378037131|gb|EHV99666.1|Escherichia coli DEC7B

88

ZP 10352687.1|Alishewanella agri BL06 78

100 ZP 10493138.1|Alishewanella aestuarii B11

EJG21846.1|Acinetobacter baumannii OIFC143

79

100 gi|410396681|gb|EKP48944.1|Acinetobacter baumannii Naval-82

ZP 01679259.1|Vibrio cholerae V52

60

100 NP 230466.1|Vibrio cholerae O1 biovar El Tor str. N16961

YP 003619440.1|Legionella pneumophila 2300/99 Alcoy YP 624708.1|Burkholderia cenocepacia AU 1054 100 YP 624949.1|Burkholderia cenocepacia AU 1054

Rra3 p21 60

Plasmid

ref|NC 015856.1| Collimonas fungivorans Ter331 chromosome ZP 05125455.1|Rhodobacteraceae bacterium KLH11

100

100 95

ZP 05125630.1|Rhodobacteraceae bacterium KLH11

ZP 10178488.1|Microvirga sp. WSM3557 ZP 10181175.1|Microvirga sp. WSM3557 YP 004535842.1|Novosphingobium sp. PP1Y

100 79

YP 001769402.1|Methylobacterium sp. 4-46 97 YP 001770195.1|Methylobacterium sp. 4-46

100 YP 003084959.1|Dyadobacter fermentans DSM 18053

YP 003084968.1|Dyadobacter fermentans DSM 18053 100

Reis4 p160077-78 Reis2 p85

98

ZP 08298797.1|Bacteroides fluxus YIT 12057 100

0.2

Plasmids

ref|NC 017861.1| Prevotella intermedia 17 chromosome chromosome II

ZP 07096791.1|Escherichia coli MS 107-1

98 100

ZP 08365469.1|Escherichia coli TA143 gi|378037131|gb|EHV99666.1|Escherichia coli DEC7B

95

ZP 10352687.1|Alishewanella agri BL06

ML

61

100 ZP 10493138.1|Alishewanella aestuarii B11

EJG21846.1|Acinetobacter baumannii OIFC143

79

100 gi|410396681|gb|EKP48944.1|Acinetobacter baumannii Naval-82

ZP 01679259.1|Vibrio cholerae V52

71

100 NP 230466.1|Vibrio cholerae O1 biovar El Tor str. N16961

YP 003619440.1|Legionella pneumophila 2300/99 Alcoy YP 624708.1|Burkholderia cenocepacia AU 1054 100 YP 624949.1|Burkholderia cenocepacia AU 1054 100 ZP 05125455.1|Rhodobacteraceae bacterium KLH11

ZP 05125630.1|Rhodobacteraceae bacterium KLH11 ZP 10178488.1|Microvirga sp. WSM3557

93

ZP 10181175.1|Microvirga sp. WSM3557 YP 004535842.1|Novosphingobium sp. PP1Y

100

YP 001769402.1|Methylobacterium sp. 4-46

91

100

100

YP 001770195.1|Methylobacterium sp. 4-46

Rra3 p21 ref|NC 015856.1| Collimonas fungivorans Ter331 chromosome 100 YP 003084959.1|Dyadobacter fermentans DSM 18053

YP 003084968.1|Dyadobacter fermentans DSM 18053 100

Reis4 p160077-78 Reis2 p85

87

ZP 08298797.1|Bacteroides fluxus YIT 12057 100

0.2

Plasmids

ref|NC 017861.1| Prevotella intermedia 17 chromosome chromosome II

Figure A106. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

100 ZP 06186225.1|Legionella longbeachae D-4968

84

YP 003456466.1|Legionella longbeachae NSW150 Rpe p26

Plasmid EKD24604.1|uncultured bacterium (gcode 4) YP 001865773.1|Nostoc punctiforme PCC 73102

72 100

YP 001866592.1|Nostoc punctiforme PCC 73102 ZP 09571330.1|Singulisphaera acidiphila DSM 18658

100 ZP 09567938.1|Singulisphaera acidiphila DSM 18658

0.2

ML

99 ZP 06186225.1|Legionella longbeachae D-4968 79

YP 003456466.1|Legionella longbeachae NSW150 Rpe p26

Plasmid

EKD24604.1|uncultured bacterium (gcode 4) ZP 09571330.1|Singulisphaera acidiphila DSM 18658 100 ZP 09567938.1|Singulisphaera acidiphila DSM 18658

YP 001865773.1|Nostoc punctiforme PCC 73102 100

0.1

YP 001866592.1|Nostoc punctiforme PCC 73102

Figure A107. Neighbor-joining (NJ) and maximum likelihood (ML) trees of RNA-directed DNA polymarases. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 001678666.1|Heliobacterium modesticaldum Ice1

NJ

100

YP 001681154.1|Heliobacterium modesticaldum Ice1 YP 001681248.1|Heliobacterium modesticaldum Ice1 ZP 08534472.1|Caldalkalibacillus thermarum TA2.A1

99

ADK35363.1|Geobacillus stearothermophilus YP 004396082.1|Clostridium botulinum BKT015925

72

ZP 08212168.1|Thermoanaerobacter ethanolicus JW 200

100 100

YP 001665838.1|Thermoanaerobacter pseudethanolicus ATCC 33223

ZP 08920131.1|Thermobacillus composti KWC4 YP 075584.1|Symbiobacterium thermophilum IAM 14863 100

YP 075623.1|Symbiobacterium thermophilum IAM 14863 EJZ16781.1|Rhizobium sp. Pop5 YP 003197752.1|Desulfohalobium retbaense DSM 5692

100 100

YP 003197718.1|Desulfohalobium retbaense DSM 5692 Reis2 p72

Plasmid

ZP 10748503.1|Novosphingobium sp. AP12

99

ZP 09566022.1|Singulisphaera acidiphila DSM 18658

99

ZP 02730511.1|Gemmata obscuriglobus UQM 2246

94

100 ZP 02733468.1|Gemmata obscuriglobus UQM 2246

0.05

100

ML

99

ZP 08212168.1|Thermoanaerobacter ethanolicus JW 200 YP 001665838.1|Thermoanaerobacter pseudethanolicus ATCC 33223 YP 004396082.1|Clostridium botulinum BKT015925 ZP 08920131.1|Thermobacillus composti KWC4

ZP 08534472.1|Caldalkalibacillus thermarum TA2.A1 100

ADK35363.1|Geobacillus stearothermophilus YP 001681154.1|Heliobacterium modesticaldum Ice1

86 100

YP 001681248.1|Heliobacterium modesticaldum Ice1 YP 001678666.1|Heliobacterium modesticaldum Ice1 YP 075584.1|Symbiobacterium thermophilum IAM 14863

100 YP 075623.1|Symbiobacterium thermophilum IAM 14863 100 100

YP 003197752.1|Desulfohalobium retbaense DSM 5692 YP 003197718.1|Desulfohalobium retbaense DSM 5692 EJZ16781.1|Rhizobium sp. Pop5 Reis2 p72

Plasmid

ZP 10748503.1|Novosphingobium sp. AP12

98

ZP 09566022.1|Singulisphaera acidiphila DSM 18658

91 89

ZP 02730511.1|Gemmata obscuriglobus UQM 2246 100 ZP 02733468.1|Gemmata obscuriglobus UQM 2246

0.05

Figure A108. Neighbor-joining (NJ) and maximum likelihood (ML) trees of mobile mystery protein B. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 07778455.1|Pseudomonas fluorescens WH6

96

NJ

76

ZP 06685213.1|Achromobacter piechaudii ATCC 43553 ZP 10103844.1|Thiothrix nivea DSM 5205 NP 103503.1|Mesorhizobium loti MAFF303099 YP 001944245.1|Chlorobium limicola DSM 245 YP 004165968.1|Cellulophaga algicola DSM 14237

99 100

YP 004734757.1|Zobellia galactanivorans ZP 01254048.1|Psychroflexus torquis ATCC 700755

YP 001952798.1|Geobacter lovleyi SZ 100

NP 952444.1|Geobacter sulfurreducens PCA YP 004366153.1|Treponema succinifaciens DSM 2489 YP 002515351.1|Thioalkalivibrio sulfidophilus HL-EbGr7

63 95

YP 004087869.1|Asticcacaulis excentricus CB 48 YP 001409380.1|Xanthobacter autotrophicus Py2 YP 782322.1|Rhodopseudomonas palustris BisA53

83

ZP 03523302.1|Rhizobium etli GR56

65 100

EJC83165.1|Rhizobium leguminosarum bv. trifolii WSM2297 NP 053281.1|Agrobacterium tumefaciens

100 99

YP 002551237.1|Agrobacterium radiobacter K84 NP 396616.1|Agrobacterium tumefaciens str. C58 NP 968583.1|Bdellovibrio bacteriovorus HD100 ZP 08778750.1|Candidatus Odyssella thessalonicensis L13

73 78

Rhe p09 100 Rra2 p086

0.1

Plasmids

ML

99

Rhe p09 Rra2 p086

62

Plasmids

ZP 08778750.1|Candidatus Odyssella thessalonicensis L13 NP 968583.1|Bdellovibrio bacteriovorus HD100 ZP 10103844.1|Thiothrix nivea DSM 5205 ZP 07778455.1|Pseudomonas fluorescens WH6 94

ZP 06685213.1|Achromobacter piechaudii ATCC 43553 NP 103503.1|Mesorhizobium loti MAFF303099 YP 001944245.1|Chlorobium limicola DSM 245 YP 004165968.1|Cellulophaga algicola DSM 14237

100

YP 004734757.1|Zobellia galactanivorans

99

ZP 01254048.1|Psychroflexus torquis ATCC 700755 YP 001952798.1|Geobacter lovleyi SZ

95

NP 952444.1|Geobacter sulfurreducens PCA YP 002515351.1|Thioalkalivibrio sulfidophilus HL-EbGr7 72

YP 004087869.1|Asticcacaulis excentricus CB 48 YP 001409380.1|Xanthobacter autotrophicus Py2 YP 004366153.1|Treponema succinifaciens DSM 2489 YP 782322.1|Rhodopseudomonas palustris BisA53 ZP 03523302.1|Rhizobium etli GR56

98

EJC83165.1|Rhizobium leguminosarum bv. trifolii WSM2297

92

NP 396616.1|Agrobacterium tumefaciens str. C58 63

NP 053281.1|Agrobacterium tumefaciens YP 002551237.1|Agrobacterium radiobacter K84

0.1

Figure A109. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 10475995.1|Pseudomonas sp. Ag1

100

NJ

99

gi|388009434|gb|EIK70685.1|Pseudomonas fluorescens Q8r1-96

100

YP 005636294.1|Xanthomonas campestris pv. raphani 756C

63

gi|330899950|gb|EGH31369.1|Pseudomonas syringae pv. japonica str. M301072 YP 001232324.1|Geobacter uraniireducens YP 325001.1|Anabaena variabilis ATCC 29413 YP 004864006.1|Candidatus Chloracidobacterium thermophilum B

83 100

YP 004626401.1|Thermodesulfatator indicus DSM 15286

72

YP 001274657.1|Roseiflexus sp. Rra2 p071

72

Plasmid

ZP 00373593.1|Wolbachia endosymbiont of Drosophila ananassae YP 001976036.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel

99

99

YP 001976088.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel Reis1767 Rau0568-69 RbeOSU0008

100

100 RbeRML0008

NP 617887.1|Methanosarcina acetivorans C2A 100

YP 002942380.1|Variovorax paradoxus S110

99

YP 004152802.1|Variovorax paradoxus EPS

100

ZP 08872570.1|Verminephrobacter aporrectodeae subsp. tuberculatae At4 YP 001516559.1|Acaryochloris marina MBIC11017

92

Ram32 p02-04 99

Plasmid

gi|307611436|emb|CBX01104.1|Legionella pneumophila 130b ZP 10108206.1|Joostella marina DSM 19592 100

ZP 06870294.1|Fusobacterium nucleatum subsp. nucleatum ATCC 23726 NP 604342.1|Fusobacterium nucleatum subsp. nucleatum ATCC 25586 ZP 04452082.1|Abiotrophia defectiva ATCC 49176

100 92

ZP 02082601.1|Clostridium bolteae ATCC BAA-613 ZP 09117542.1|Clostridium clostridioforme 2 1 49FAA

0.2

99 RbeOSU0008 98

RbeRML0008

71

Rau0568-Rau0569 Reis1767

80

ML

YP 001976036.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel 99

97

YP 001976088.1|Wolbachia endosymbiont of Culex quinquefasciatus Pel Rra2 p071

84

Plasmid

ZP 00373593.1|Wolbachia endosymbiont of Drosophila ananassae YP 325001.1|Anabaena variabilis ATCC 29413 YP 001274657.1|Roseiflexus sp.

67

YP 004626401.1|Thermodesulfatator indicus DSM 15286 YP 004864006.1|Candidatus Chloracidobacterium thermophilum B YP 001232324.1|Geobacter uraniireducens gi|330899950|gb|EGH31369.1|Pseudomonas syringae pv. japonica str. M301072 YP 005636294.1|Xanthomonas campestris pv. raphani 756C

99

ZP 10475995.1|Pseudomonas sp. Ag1

93 98

gi|388009434|gb|EIK70685.1|Pseudomonas fluorescens Q8r1-96 96 100 100

YP 002942380.1|Variovorax paradoxus S110 YP 004152802.1|Variovorax paradoxus EPS ZP 08872570.1|Verminephrobacter aporrectodeae subsp. tuberculatae At4 YP 001516559.1|Acaryochloris marina MBIC11017

72

Ram32 p02-04 100

Plasmid

CBX01104.1|Legionella pneumophila 130b

100

NP 617887.1|Methanosarcina acetivorans C2A ZP 10108206.1|Joostella marina DSM 19592 100 67

NP 604342.1|Fusobacterium nucleatum subsp. nucleatum ATCC 25586 ZP 04452082.1|Abiotrophia defectiva ATCC 49176

100 98 74

0.2

ZP 06870294.1|Fusobacterium nucleatum subsp. nucleatum ATCC 23726

ZP 02082601.1|Clostridium bolteae ATCC BAA-613 ZP 09117542.1|Clostridium clostridioforme 2 1 49FAA

Figure A110. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

100 gi|312172373|emb|CBX80630.1|Erwinia amylovora ATCC BAA-2158

NJ

YP 003531117.1|Erwinia amylovora CFBP1430

96

ZP 10110701.1|Serratia plymuthica PRI-2C 100

91

ZP 09831231.1|Pantoea stewartii subsp. stewartii DC283 RfeI1 p68 100 Rfe p67 77 Rfe pd34

Plasmids

YP 003073614.1|Teredinibacter turnerae T7901 YP 065650.1|Desulfotalea psychrophila LSv54 YP 434610.1|Hahella chejuensis KCTC 2396

70

ZP 00518921.1|Crocosphaera watsonii WH 8501 100

EHJ10756.1|Crocosphaera watsonii WH 0003

0.1

100 gi|312172373|emb|CBX80630.1|Erwinia amylovora ATCC BAA-2158

ML

YP 003531117.1|Erwinia amylovora CFBP1430 ZP 10110701.1|Serratia plymuthica PRI-2C 99

ZP 09831231.1|Pantoea stewartii subsp. stewartii DC283 Rfe p67 Rfe pd34 100

Plasmids

RfeI1 p68 YP 003073614.1|Teredinibacter turnerae T7901 YP 434610.1|Hahella chejuensis KCTC 2396 YP 065650.1|Desulfotalea psychrophila LSv54 ZP 00518921.1|Crocosphaera watsonii WH 8501 100 EHJ10756.1|Crocosphaera watsonii WH 0003

0.1

Figure A111. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

67 ZP 08683460.1|Neisseria macacae ATCC 33926

NJ

100

ZP 05978913.1|Neisseria mucosa ATCC 25996 ZP 05319948.1|Neisseria sicca ATCC 29256

69

ZP 08018058.1|Lautropia mirabilis ATCC 51599 ZP 04603269.1|Kingella oralis ATCC 51147 ZP 08577001.1|Lactobacillus farciminis KCTC 3681 YP 001728355.1|Leuconostoc citreum KM20 ZP 08832835.1|Prevotella oulorum F0390 100

ZP 08579493.1|Prevotella multisaccharivorax DSM 17128

EGC77940.1|Treponema denticola F0402

Plasmid

Ram32 p37

ZP 08756653.1|Haemophilus pittmaniae HK 85

64

EIJ31534.1|Haemophilus parainfluenzae HK2019

77

ZP 09185817.1|parainfluenzae CCUG 13788

82 89

EGY34463.1|Aggregatibacter actinomycetemcomitans serotype e str. SC1083 ZP 05734502.1|Dialister invisus DSM 15470 ZP 09584763.1|Eubacterium infirmum F0142

0.1

ZP 08683460.1|Neisseria macacae ATCC 33926 96

ZP 05319948.1|Neisseria sicca ATCC 29256 ZP 05978913.1|Neisseria mucosa ATCC 25996

ML

ZP 08018058.1|Lautropia mirabilis ATCC 51599 ZP 04603269.1|Kingella oralis ATCC 51147 ZP 08577001.1|Lactobacillus farciminis KCTC 3681 Ram32 p37

Plasmid

ZP 08756653.1|Haemophilus pittmaniae HK 85

72

EIJ31534.1|Haemophilus parainfluenzae HK2019

76

ZP 09185817.1|parainfluenzae CCUG 13788

67 81

EGY34463.1|Aggregatibacter actinomycetemcomitans serotype e str. SC1083

EGC77940.1|Treponema denticola F0402 ZP 08832835.1|Prevotella oulorum F0390 100

ZP 08579493.1|Prevotella multisaccharivorax DSM 17128 YP 001728355.1|Leuconostoc citreum KM20 ZP 09584763.1|Eubacterium infirmum F0142 ZP 05734502.1|Dialister invisus DSM 15470

0.1

Figure

A112.

Neighbor-joining

(NJ)

and

maximum

likelihood (ML)

trees

of

transposase/integrase containing HTH_21 and rve domains. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 06733088.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535

98

NJ

62

YP 363027.1|Xanthomonas campestris pv. vesicatoria str. 85-10

99

ZP 11173514.1|Alcanivorax hongdengensis A-11-3 ZP 10205060.1|Rhodanobacter thiooxydans LCS2 EKU83635.1|Massilia timonae CCUG 45783

77

YP 006331473.1|Burkholderia sp. KJ006 YP 837074.1|Burkholderia cenocepacia HI2424

100 77

YP 003743989.1|Ralstonia solanacearum CFBP2957

YP 957213.1|Marinobacter aquaeolei VT8 60

YP 005884785.1|Marinobacter adhaerens HP15 YP 751535.1|Shewanella frigidimarina NCIMB 400

100 100

YP 752121.1|Shewanella frigidimarina NCIMB 400

ZP 09290650.1|Halomonas sp. GFAJ-1 ZP 01074709.1|Marinomonas sp. MED121

63 100

ZP 01075734.1|Marinomonas sp. MED121

Ram18 p13-14 Rrh p13

Plasmids

Rma p12

99

RmaB p09

63

0.05

90

ML

ZP 06733088.1|Xanthomonas fuscans subsp. aurantifolii str. ICPB 10535 YP 363027.1|Xanthomonas campestris pv. vesicatoria str. 85-10

99

ZP 11173514.1|Alcanivorax hongdengensis A-11-3 77

ZP 10205060.1|Rhodanobacter thiooxydans LCS2 YP 003743989.1|Ralstonia solanacearum CFBP2957

83 100

YP 837074.1|Burkholderia cenocepacia HI2424 YP 006331473.1|Burkholderia sp. KJ006

EKU83635.1|Massilia timonae CCUG 45783 YP 005884785.1|Marinobacter adhaerens HP15 YP 957213.1|Marinobacter aquaeolei VT8 ZP 09290650.1|Halomonas sp. GFAJ-1

100

ZP 01074709.1|Marinomonas sp. MED121

80

100 ZP 01075734.1|Marinomonas sp. MED121

YP 751535.1|Shewanella frigidimarina NCIMB 400 100

YP 752121.1|Shewanella frigidimarina NCIMB 400

Ram18 p13-14 Rrh p13 83

Plasmids

Rma p12 RmaB p09

0.1

Figure A113. Neighbor-joining (NJ) and maximum likelihood (ML) trees of cytosinespecific methyltransferase. Bootstrap supports higher than or equal to 60% are shown on the branches.

100 ZP 05987073.1|Neisseria lactamica ATCC 23970

NJ

65

YP 004047808.1|Neisseria lactamica 020-06 EGT83114.1|Haemophilus haemolyticus M21639 ZP 08537434.1|Methylophaga aminisulfidivorans MP EGB64187.1|Escherichia coli TA007 YP 004250314.1|Mycoplasma suis str. Illinois 100

YP 004249384.1|Mycoplasma suis KI3806 Rau p16

Plasmid

0.1

87 ZP 05987073.1|Neisseria lactamica ATCC 23970

YP 004047808.1|Neisseria lactamica 020-06

ML

EGT83114.1|Haemophilus haemolyticus M21639 ZP 08537434.1|Methylophaga aminisulfidivorans MP EGB64187.1|Escherichia coli TA007 YP 004250314.1|Mycoplasma suis str. Illinois 99 YP 004249384.1|Mycoplasma suis KI3806

Rau p16

0.2

Plasmid

Figure A114. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 70 EGH46201.1|Pseudomonas syringae pv. pisi str. 1704B 100

NP 964009.1|Pseudomonas syringae pv. syringae gi|389596314|gb|AFK89079.1|Pseudomonas syringae

ZP 04754316.1|Actinobacillus minor NM305 ref|NC 007094.1| Actinobacillus porcitonsillarum plasmid pKMA505 complete sequence Length 8632

100

ref|NC 007095.1| Actinobacillus porcitonsillarum plasmid pIMD50 complete sequence Length 8751 WP 017191144.1|Vibrio harveyi Rpe p04

89

Plasmids

Rfe p30

75 99

RfeI1 p31 100 gi|378242386|gb|EHY02341.1|Escherichia coli DEC15A

gi|371603537|gb|EHN92191.1|Escherichia coli H397 YP 005202441.1|Rahnella aquatilis CIP 78.65 ATCC 33071

66

ZP 08040539.1|Serratia symbiotica str. Tucson

80 99

ZP 06641742.1|Serratia odorifera DSM 4582

0.1

ML 83

ZP 08040539.1|Serratia symbiotica str. Tucson ZP 06641742.1|Serratia odorifera DSM 4582 YP 005202441.1|Rahnella aquatilis CIP 78.65 ATCC 33071 gi|378242386|gb|EHY02341.1|Escherichia coli DEC15A 100

gi|371603537|gb|EHN92191.1|Escherichia coli H397

ref|NC 007094.1| Actinobacillus porcitonsillarum plasmid pKMA505 complete sequence Length 8632 100

ZP 04754316.1|Actinobacillus minor NM305 ref|NC 007095.1| Actinobacillus porcitonsillarum plasmid pIMD50 complete sequence Length 8751 EGH46201.1|Pseudomonas syringae pv. pisi str. 1704B 99

NP 964009.1|Pseudomonas syringae pv. syringae gi|389596314|gb|AFK89079.1|Pseudomonas syringae WP 017191144.1|Vibrio harveyi

Rpe p04

74

Rfe p30 86

0.1

RfeI1 p31

Plasmids

Figure A115. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 004196188.1|Desulfobulbus propionicus DSM 2032

NJ

gi|358636309|dbj|BAL23606.1|Azoarcus sp. KH32C YP 574366.1|Chromohalobacter salexigens DSM 3043 ZP 09435454.1|Bradyrhizobium sp. STM 3843 ZP 01902883.1|Roseobacter sp. AzwK-3b YP 002514837.1|Thioalkalivibrio sulfidophilus HL-EbGr7 ZP 01313942.1|Desulfuromonas acetoxidans DSM 684 YP 005845381.1|Ignavibacterium album JCM 16511 65

ZP 09549145.1|Caldithrix abyssi DSM 13497 YP 001600515.1|Gluconacetobacter diazotrophicus PAl 5 ZP 08901324.1|Gluconacetobacter europaeus LMG 18494 YP 740932.1|Alkalilimnicola ehrlichii MLHE-1 YP 676040.1|Chelativorans sp. BNC1 ZP 01126899.1|Nitrococcus mobilis Nb-231 NP 875938.1|Prochlorococcus marinus subsp. marinus str. CCMP1375

100

YP 001550491.1|Prochlorococcus marinus str. MIT 9211

Plasmid

Rmo p07

YP 001376354.1|Bacillus cytotoxicus NVH 391-98 ZP 04135083.1|Bacillus thuringiensis serovar thuringiensis str. T01001

100

NP 834125.1|Bacillus cereus ATCC 14579

83 66

ZP 04067088.1|Bacillus thuringiensis IBL 4222 YP 001647053.1|Bacillus weihenstephanensis KBAB4

0.1

ZP 04135083.1|Bacillus thuringiensis serovar thuringiensis str. T01001 NP 834125.1|Bacillus cereus ATCC 14579

ML

97

ZP 04067088.1|Bacillus thuringiensis IBL 4222 YP 001647053.1|Bacillus weihenstephanensis KBAB4 YP 001376354.1|Bacillus cytotoxicus NVH 391-98

ZP 08901324.1|Gluconacetobacter europaeus LMG 18494 YP 001600515.1|Gluconacetobacter diazotrophicus PAl 5 YP 740932.1|Alkalilimnicola ehrlichii MLHE-1 YP 676040.1|Chelativorans sp. BNC1 ZP 01126899.1|Nitrococcus mobilis Nb-231 YP 002514837.1|Thioalkalivibrio sulfidophilus HL-EbGr7 ZP 01313942.1|Desulfuromonas acetoxidans DSM 684 YP 005845381.1|Ignavibacterium album JCM 16511 ZP 09549145.1|Caldithrix abyssi DSM 13497 YP 004196188.1|Desulfobulbus propionicus DSM 2032 gi|358636309|dbj|BAL23606.1|Azoarcus sp. KH32C ZP 01902883.1|Roseobacter sp. AzwK-3b YP 574366.1|Chromohalobacter salexigens DSM 3043 ZP 09435454.1|Bradyrhizobium sp. STM 3843 Rmo p07

Plasmid

NP 875938.1|Prochlorococcus marinus subsp. marinus str. CCMP1375 100

0.1

YP 001550491.1|Prochlorococcus marinus str. MIT 9211

Figure A116. Neighbor-joining (NJ) and maximum likelihood (ML) trees of putative lytic transglycosylase (LT) domain protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ ZP 08990336.1|Mesorhizobium australicum WSM2073 98

NP 104157.1|Mesorhizobium loti MAFF303099 ZP 09089535.1|Mesorhizobium amorphae CCNWGS0123

93 66

WP 023832952.1|Mesorhizobium sp. L103C119B0

83

ZP 10235605.1|Nitratireductor aquibiodomus 100

ZP 02165117.1|Hoeflea phototrophica DFL-43 YP 005081150.1|Pseudovibrio sp. FO-BEG1 100

ZP 05086874.1|Pseudovibrio sp. JE062

Reis3 p40 Rra2 p084

100 99

Plasmids

Rra3 p24

100 ZP 08776810.1|Candidatus Odyssella thessalonicensis L13

WP 010297929.1|Candidatus Odyssella thessalonicensis YP 004680204.1|Candidatus Midichloria mitochondrii IricVA YP 006370078.1|Tistrella mobilis KA081020-065

92

YP 002296455.1|Rhodospirillum centenum SW YP 004693213.1|Roseobacter litoralis Och 149

95

ZP 01880088.1|Roseovarius sp. TM1035 ZP 01878591.1|Roseovarius sp. TM1035 YP 001167859.1|Rhodobacter sphaeroides ATCC 17025

97 100

0.2

YP 353148.1|Rhodobacter sphaeroides 2.4.1

64

ML

ZP 08990336.1|Mesorhizobium australicum WSM2073 NP 104157.1|Mesorhizobium loti MAFF303099

61

ZP 09089535.1|Mesorhizobium amorphae CCNWGS0123 WP 023832952.1|Mesorhizobium sp. L103C119B0 ZP 10235605.1|Nitratireductor aquibiodomus

98

ZP 02165117.1|Hoeflea phototrophica DFL-43 YP 005081150.1|Pseudovibrio sp. FO-BEG1 98 ZP 05086874.1|Pseudovibrio sp. JE062

Reis3 p40 93 61

Rra2 p084

Plasmids

Rra3 p24

99 ZP 08776810.1|Candidatus Odyssella thessalonicensis L13

WP 010297929.1|Candidatus Odyssella thessalonicensis YP 004680204.1|Candidatus Midichloria mitochondrii IricVA YP 006370078.1|Tistrella mobilis KA081020-065

68

YP 002296455.1|Rhodospirillum centenum SW YP 004693213.1|Roseobacter litoralis Och 149

89

ZP 01880088.1|Roseovarius sp. TM1035 ZP 01878591.1|Roseovarius sp. TM1035 YP 001167859.1|Rhodobacter sphaeroides ATCC 17025

84 98

0.2

YP 353148.1|Rhodobacter sphaeroides 2.4.1

Figure A117. Neighbor-joining (NJ) and maximum likelihood (ML) trees of putative DNAbinding protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

YP 002537101.1|Geobacter daltonii FRC-32

100 87

YP 001953755.1|Geobacter lovleyi SZ

99

YP 001952797.1|Geobacter lovleyi SZ NP 952443.1|Geobacter sulfurreducens PCA NP 052873.1|Coxiella burnetii YP 002515352.1|Thioalkalivibrio sulfidophilus HL-EbGr7 YP 002540887.1|Agrobacterium radiobacter K84 100

Rra2 p085 Rhe p08

Plasmids

ZP 10103845.1|Thiothrix nivea DSM 5205 ZP 06685212.1|Achromobacter piechaudii ATCC 43553

77 100

YP 994816.1|Verminephrobacter eiseniae EF01-2 NP 103504.1|Mesorhizobium loti MAFF303099

100

YP 001981707.1|Cellvibrio japonicus Ueda107 YP 003503289.1|Denitrovibrio acetiphilus DSM 12809

61

ZP 09017749.1|Brenneria sp. EniD312

0.1

89

ML

71 84

YP 002537101.1|Geobacter daltonii FRC-32 YP 001953755.1|Geobacter lovleyi SZ YP 001952797.1|Geobacter lovleyi SZ NP 952443.1|Geobacter sulfurreducens PCA YP 003503289.1|Denitrovibrio acetiphilus DSM 12809

NP 052873.1|Coxiella burnetii NP 103504.1|Mesorhizobium loti MAFF303099 100

YP 001981707.1|Cellvibrio japonicus Ueda107 YP 002515352.1|Thioalkalivibrio sulfidophilus HL-EbGr7

60

YP 002540887.1|Agrobacterium radiobacter K84 100 Rra2 p085

Rhe p08

Plasmids

ZP 10103845.1|Thiothrix nivea DSM 5205 66

ZP 06685212.1|Achromobacter piechaudii ATCC 43553 100

0.2

YP 994816.1|Verminephrobacter eiseniae EF01-2

Figure A118. Neighbor-joining (NJ) and maximum likelihood (ML) trees of ParA-like family protein. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

88 ZP 10448554.1|Bartonella doshiae NCTC 12862 71 YP 002972838.1|Bartonella grahamii as4aup 95 100

ZP 10469912.1|Bartonella taylorii 8TBB ZP 10470080.1|Bartonella alsatica IBS 382

ZP 10464586.1|Bartonella melophagi K-2C Rmo p27

Plasmid

ZP 11132263.1|Celeribacter baekdonensis B30 ZP 11483622.1|Aggregatibacter actinomycetemcomitans D17P-2

70

ZP 05621066.1|Enhydrobacter aerosaccus SK60

92

YP 006961718.1|Psychrobacter sp. DAB AL62B

99 97

YP 068544.1|Yersinia pseudotuberculosis IP 32953

0.2

ML 66 ZP 10469912.1|Bartonella taylorii 8TBB 61 ZP 10470080.1|Bartonella alsatica IBS 382 96

ZP 10448554.1|Bartonella doshiae NCTC 12862 66 YP 002972838.1|Bartonella grahamii as4aup

ZP 10464586.1|Bartonella melophagi K-2C Rmo p27

Plasmid

ZP 11132263.1|Celeribacter baekdonensis B30 ZP 11483622.1|Aggregatibacter actinomycetemcomitans D17P-2

44

ZP 05621066.1|Enhydrobacter aerosaccus SK60

37

YP 006961718.1|Psychrobacter sp. DAB AL62B

39 34

0.2

YP 068544.1|Yersinia pseudotuberculosis IP 32953

Figure A119. Neighbor-joining (NJ) and maximum likelihood (ML) trees of type I restriction-modification system methyltransferase subunit. Bootstrap supports higher than or equal to 60% are shown on the branches.

gi|342234925|gb|EGT99557.1|Acinetobacter baumannii ABNIH3 100

NJ

YP 001714555.1|Acinetobacter baumannii AYE ZP 04661739.1|Acinetobacter baumannii AB900

99 100

RbeOSU1764 RbeRML1721

84

100

Rau0230 ZP 06290586.1|Peptoniphilus lacrimalis 315-B

66

ZP 08448618.1|Capnocytophaga sp. oral taxon 329 str. F0087

100 100

ZP 09106471.1|Paraprevotella clara YIT 11840 YP 002004254.1|Candidatus Phytoplasma mali YP 004843194.1|Flavobacterium branchiophilum FL-15

100

ZP 04009757.1|Lactobacillus salivarius ATCC 11741 RfeI1 p11-12 100 94

Rfe p11-12

Plasmids

Rfe pd11-12

0.1

gi|342234925|gb|EGT99557.1|Acinetobacter baumannii ABNIH3

ML

100

YP 001714555.1|Acinetobacter baumannii AYE ZP 04661739.1|Acinetobacter baumannii AB900

95

95 RbeOSU1764

RbeRML1721

83

100

Rau0230

ZP 06290586.1|Peptoniphilus lacrimalis 315-B 100

ZP 08448618.1|Capnocytophaga sp. oral taxon 329 str. F0087 100 ZP 09106471.1|Paraprevotella clara YIT 11840

YP 002004254.1|Candidatus Phytoplasma mali YP 004843194.1|Flavobacterium branchiophilum FL-15 100

ZP 04009757.1|Lactobacillus salivarius ATCC 11741 RfeI1 p11-12 Rfe p11-12 100

Rfe pd11-12

0.2

Plasmids

Figure A120. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 001905949.1|Erwinia tasmaniensis Et1/99

NJ

WP 022642417.1|Pseudomonas sp. CMAA1215 ref|NZ GL636367.1| Serratia symbiotica str. Tucson Rpe p30 Rra2 p105

99

Plasmids

gi|284008257|emb|CBA74575.1|Arsenophonus nasoniae YP 047795.1|Acinetobacter sp. ADP1 100 100

ZP 03824266.1|Acinetobacter sp. ATCC 27244 ZP 06729012.1|Acinetobacter haemolyticus ATCC 19194 ZP 06058080.1|Acinetobacter calcoaceticus

88

YP 002324297.1|Acinetobacter baumannii AB307-0294

99

100 YP 001712320.1|Acinetobacter baumannii AYE

0.2

YP 001905949.1|Erwinia tasmaniensis Et1/99

ML

WP 022642417.1|Pseudomonas sp. CMAA1215 ref|NZ GL636367.1| Serratia symbiotica str. Tucson gi|284008257|emb|CBA74575.1|Arsenophonus nasoniae Rpe p30 Rra2 p105

85

Plasmids YP 047795.1|Acinetobacter sp. ADP1

77 99

ZP 03824266.1|Acinetobacter sp. ATCC 27244 ZP 06729012.1|Acinetobacter haemolyticus ATCC 19194 ZP 06058080.1|Acinetobacter calcoaceticus 96

YP 002324297.1|Acinetobacter baumannii AB307-0294 98 YP 001712320.1|Acinetobacter baumannii AYE

0.2

Figure A121. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

GAB29814.1|Acetobacter pasteurianus subsp. pasteurianus LMG 1262

NJ

78 100

gi|371460410|dbj|GAB27079.1|Acetobacter pasteurianus NBRC 101655 YP 003188469.1|Acetobacter pasteurianus IFO 3283-01 ZP 08244365.1|Acetobacter pomorum DM001

YP 006369575.1|Tistrella mobilis KA081020-065 ZP 09876049.1|Phaeospirillum molischianum DSM 120 YP 004865033.1|Micavibrio aeruginosavorus ARL-13 Rhe p15

92

Plasmids

Rra2 p090

100

100

YP 580701.1|Psychrobacter cryohalolentis K5 YP 264264.1|Psychrobacter arcticus 273-4

100

77

YP 003642196.1|Thiomonas intermedia K12 CAZ87280.1|Thiomonas sp. 3As

YP 001900229.1|Ralstonia pickettii 12J

99

ZP 10365796.1|Ralstonia sp. PBA

100 69

ZP 09627137.1|Cupriavidus basilensis OR16

0.2

GAB29814.1|Acetobacter pasteurianus subsp. pasteurianus LMG 1262 94

ML

100

gi|371460410|dbj|GAB27079.1|Acetobacter pasteurianus NBRC 101655 YP 003188469.1|Acetobacter pasteurianus IFO 3283-01 ZP 08244365.1|Acetobacter pomorum DM001

YP 004865033.1|Micavibrio aeruginosavorus ARL-13 68

Rhe p15

78 100

Rra2 p090

Plasmids

YP 006369575.1|Tistrella mobilis KA081020-065 ZP 09876049.1|Phaeospirillum molischianum DSM 120 99 YP 580701.1|Psychrobacter cryohalolentis K5

YP 264264.1|Psychrobacter arcticus 273-4 100 YP 003642196.1|Thiomonas intermedia K12

CAZ87280.1|Thiomonas sp. 3As ZP 10365796.1|Ralstonia sp. PBA

93

ZP 09627137.1|Cupriavidus basilensis OR16

96 65

0.2

YP 001900229.1|Ralstonia pickettii 12J

Figure A122. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NP 485895.1|Nostoc sp. PCC 7120

100 62

NJ

NP 485895.1|Nostoc sp. PCC 7120(2) ZP 04087109.1|Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

63

EIJ75087.1|Leptospirillum sp. Group II C75 100

EIJ75130.1|Leptospirillum sp. Group II C75 gi|338821104|gb|EGP55073.1|Agrobacterium tumefaciens F2

100

EHS52843.1|Rhizobium sp. PDO-076 YP 004023355.1|Caldicellulosiruptor kronotskyensis 2002 YP 004341611.1|Archaeoglobus veneficus SNP6 Reis3 p23

Plasmid

ZP 09702886.1|Methanoplanus limicola DSM 2279 EGQ98883.1|Vibrio cholerae HE39 YP 004664862.1|Myxococcus fulvus HW-1

100 84

EJJ19593.1|Chondromyces apiculatus DSM 436 YP 001622208.1|Brucella suis ATCC 23445

99 100

ZP 05962567.1|Brucella neotomae 5K33 ZP 06933879.1|Brucella abortus bv. 5 str. B3196 ZP 08829144.1|endosymbiont of Riftia pachyptila (vent Ph05) ZP 04564067.1|Mollicutes bacterium D7

0.2

ML

100 NP 485895.1|Nostoc sp. PCC 7120

NP 485895.1|Nostoc sp. PCC 7120(2) ZP 04087109.1|Bacillus thuringiensis serovar huazhongensis BGSC 4BD1 EIJ75087.1|Leptospirillum sp. Group II C75 100 EIJ75130.1|Leptospirillum sp. Group II C75

gi|338821104|gb|EGP55073.1|Agrobacterium tumefaciens F2 100

EHS52843.1|Rhizobium sp. PDO-076

YP 004341611.1|Archaeoglobus veneficus SNP6 YP 004023355.1|Caldicellulosiruptor kronotskyensis 2002 Reis3 p23

Plasmid

ZP 09702886.1|Methanoplanus limicola DSM 2279 ZP 08829144.1|endosymbiont of Riftia pachyptila (vent Ph05) EGQ98883.1|Vibrio cholerae HE39 100 69

YP 004664862.1|Myxococcus fulvus HW-1 EJJ19593.1|Chondromyces apiculatus DSM 436

ZP 05962567.1|Brucella neotomae 5K33

77 100

YP 001622208.1|Brucella suis ATCC 23445 ZP 06933879.1|Brucella abortus bv. 5 str. B3196 ZP 04564067.1|Mollicutes bacterium D7

0.2

Figure A123. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

RmaB p03

NJ

Rrh p18 64

Rma p18

100

Plasmids

Ram18 p07 Rra1 p22

YP 003199369.1|Desulfohalobium retbaense DSM 5692 ZP 10459845.1|Bartonella elizabethae ZP 10459984.1|Bartonella washoensis 085-0475

94 63

ZP 10468172.1|Bartonella birtlesii LL-WM9 YP 001609991.1|Bartonella tribocorum CIP 105476

0.2

Rma p18 75

ML

69 100

Rrh p18 RmaB p03

Plasmids

Ram18 p07 Rra1 p22

YP 003199369.1|Desulfohalobium retbaense DSM 5692 ZP 10459984.1|Bartonella washoensis 085-0475 77

YP 001609991.1|Bartonella tribocorum CIP 105476 ZP 10468172.1|Bartonella birtlesii LL-WM9 ZP 10459845.1|Bartonella elizabethae

0.2

Figure A124. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 09646632.1|Bradyrhizobium sp. WSM471

74

NJ

100

ZP 09645451.1|Bradyrhizobium sp. WSM471 YP 001990132.1|Rhodopseudomonas palustris TIE-1

78

ZP 01047797.1|Nitrobacter sp. Nb-311A 100 ZP 01047777.1|Nitrobacter sp. Nb-311A

YP 005033842.1|Azospirillum brasilense Sp245 83

ZP 10181240.1|Microvirga sp. WSM3557 YP 001524199.1|Azorhizobium caulinodans ORS 571 YP 002546633.1|Agrobacterium radiobacter K84

83

gi|392517827|gb|EIW42559.1|Rhizobium leguminosarum bv. trifolii WU95

100 100

gi|393182631|gb|EJC82670.1|Rhizobium leguminosarum bv. trifolii WSM2297 YP 004551414.1|Sinorhizobium meliloti AK83 100

YP 001314889.1|Sinorhizobium medicae WSM419

Plasmid

Rmo p20

YP 001622365.1|Brucella suis ATCC 23445

93 100

YP 223437.1|Brucella abortus bv. 1 str. 9-941 NP 541689.1|Brucella melitensis bv. 1 str. 16M ZP 05952573.1|Brucella pinnipedialis M163/99/10

0.1

ZP 09646632.1|Bradyrhizobium sp. WSM471

72 97

ZP 09645451.1|Bradyrhizobium sp. WSM471 YP 001990132.1|Rhodopseudomonas palustris TIE-1

87

ML

ZP 01047797.1|Nitrobacter sp. Nb-311A 77

100 ZP 01047777.1|Nitrobacter sp. Nb-311A

YP 005033842.1|Azospirillum brasilense Sp245

32 79 85

ZP 10181240.1|Microvirga sp. WSM3557

YP 001524199.1|Azorhizobium caulinodans ORS 571 YP 002546633.1|Agrobacterium radiobacter K84 gi|392517827|gb|EIW42559.1|Rhizobium leguminosarum bv. trifolii WU95

87 80

gi|393182631|gb|EJC82670.1|Rhizobium leguminosarum bv. trifolii WSM2297 YP 004551414.1|Sinorhizobium meliloti AK83

100

YP 001314889.1|Sinorhizobium medicae WSM419 Rmo p20

YP 001622365.1|Brucella suis ATCC 23445 83

YP 223437.1|Brucella abortus bv. 1 str. 9-941 98 NP 541689.1|Brucella melitensis bv. 1 str. 16M

ZP 05952573.1|Brucella pinnipedialis M163/99/10

0.2

Plasmid

Figure A125. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ YP 001996708.1|Chloroherpeton thalassium ATCC 35110 WP 007089228.1|Thalassospira xiamenensis YP 002761650.1|Gemmatimonas aurantiaca T-27 ZP 05033497.1|Brevundimonas sp. BAL3 74

100

YP 002130437.1|Phenylobacterium zucineum HLK1 ZP 02186494.1|alpha proteobacterium BAL199 YP 004865993.1|Micavibrio aeruginosavorus ARL-13 Rhe p48 Rra2 p018

100 100 61

Plasmids

YP 006444253.1|Anaerobaculum mobile DSM 13181 ZP 06439370.1|Anaerobaculum hydrogeniformans ATCC BAA-1850 YP 003196835.1|Robiginitalea biformata HTCC2501 ZP 10186564.1|Acinetobacter sp. HA

74 99 99

YP 156162.1|Idiomarina loihiensis L2TR ZP 01042508.1|Idiomarina baltica OS145 ZP 08537008.1|Methylophaga aminisulfidivorans MP

96 95

YP 342153.1|Nitrosococcus oceani ATCC 19707 100 ZP 05048836.1|Nitrosococcus oceani AFC27

0.1

YP 001996708.1|Chloroherpeton thalassium ATCC 35110

ML

WP 007089228.1|Thalassospira xiamenensis 85

ZP 05033497.1|Brevundimonas sp. BAL3

100

YP 002130437.1|Phenylobacterium zucineum HLK1 YP 002761650.1|Gemmatimonas aurantiaca T-27 76

ZP 02186494.1|alpha proteobacterium BAL199 YP 004865993.1|Micavibrio aeruginosavorus ARL-13 Rhe p48 Rra2 p018

100

Plasmids

YP 003196835.1|Robiginitalea biformata HTCC2501 100 YP 006444253.1|Anaerobaculum mobile DSM 13181

ZP 06439370.1|Anaerobaculum hydrogeniformans ATCC BAA-1850 ZP 10186564.1|Acinetobacter sp. HA 100 YP 342153.1|Nitrosococcus oceani ATCC 19707 100

ZP 05048836.1|Nitrosococcus oceani AFC27 93

ZP 08537008.1|Methylophaga aminisulfidivorans MP YP 156162.1|Idiomarina loihiensis L2TR 98

0.2

ZP 01042508.1|Idiomarina baltica OS145

Figure A126. Neighbor-joining (NJ) and maximum likelihood (ML) trees of DNA-directed DNA polymerase. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 003049045.1|Methylotenera mobilis JLW8

100

YP 003674818.1|Methylotenera versatilis 301 YP 006526950.1|Melioribacter roseus P3M

NJ

77

ZP 10188553.1|Rhodanobacter sp. 115 ZP 02926657.1|Verrucomicrobium spinosum DSM 4136 YP 004271649.1|Planctomyces brasiliensis DSM 5305 ZP 02733163.1|Gemmata obscuriglobus UQM 2246

63 73

YP 003508789.1|Meiothermus ruber DSM 1279

81 99

YP 003683773.1|Meiothermus silvanus DSM 9946 YP 002754887.1|Acidobacterium capsulatum ATCC 51196 YP 004216157.1|Granulicella tundricola MP5ACTX9

67 99

YP 005059804.1|Granulicella mallensis MP5ACTX8 100

YP 006419897.1|Terriglobus roseus DSM 18391 80

YP 004184535.1|Terriglobus saanensis SP1PR4 YP 004865186.1|Micavibrio aeruginosavorus ARL-13

ZP 11130484.1|Oceanibaculum indicum P24 YP 004087439.1|Asticcacaulis excentricus CB 48

79

ZP 10342162.1|Sphingomonas sp. PAMC 26605

65 100

ZP 10423852.1|Sphingomonas sp. PAMC 26617 Reis1 p63 Rhe p20

100 100

0.1

Rra2 p099-100

Plasmids

ML

YP 003049045.1|Methylotenera mobilis JLW8

100 60

YP 003674818.1|Methylotenera versatilis 301 ZP 10188553.1|Rhodanobacter sp. 115

89

YP 006526950.1|Melioribacter roseus P3M ZP 02926657.1|Verrucomicrobium spinosum DSM 4136 YP 004271649.1|Planctomyces brasiliensis DSM 5305 ZP 02733163.1|Gemmata obscuriglobus UQM 2246

61

YP 003508789.1|Meiothermus ruber DSM 1279

74 100

YP 003683773.1|Meiothermus silvanus DSM 9946 YP 002754887.1|Acidobacterium capsulatum ATCC 51196 YP 004216157.1|Granulicella tundricola MP5ACTX9

63 97

YP 005059804.1|Granulicella mallensis MP5ACTX8 100

YP 006419897.1|Terriglobus roseus DSM 18391

99

YP 004184535.1|Terriglobus saanensis SP1PR4 YP 004865186.1|Micavibrio aeruginosavorus ARL-13

ZP 11130484.1|Oceanibaculum indicum P24 YP 004087439.1|Asticcacaulis excentricus CB 48 ZP 10342162.1|Sphingomonas sp. PAMC 26605 100

ZP 10423852.1|Sphingomonas sp. PAMC 26617 Reis1 p63 Rhe p20

100 100

0.2

Rra2 p099-100

Plasmids

Figure A127. Neighbor-joining (NJ) and maximum likelihood (ML) trees of hyaluronidase. Bootstrap supports higher than or equal to 60% are shown on the branches.

YP 856012.1|Aeromonas hydrophila subsp. hydrophila ATCC 7966

100 78

ZP 08520118.1|Aeromonas caviae Ae398

100

YP 001142651.1|Aeromonas salmonicida subsp. salmonicida A449

NJ

YP 004393364.1|Aeromonas veronii B565 ZP 10135350.1|Cellvibrio sp. BR 77

98

YP 001981838.1|Cellvibrio japonicus Ueda107 ZP 01894623.1|Marinobacter algicola DG893 ZP 01735697.1|Marinobacter sp. ELB17

100

ZP 09160383.1|Marinobacter manganoxydans MnI7-9

90

YP 960732.1|Marinobacter aquaeolei VT8

94

100 YP 005431247.1|Marinobacter hydrocarbonoclasticus ATCC 49840

ZP 09251637.1|Acaryochloris sp. CCMEE 5410 100

YP 001514707.1|Acaryochloris marina MBIC11017 RfeI1 p73 100 Rfe p74 78 Rfe pd41

Plasmids

0.2

YP 856012.1|Aeromonas hydrophila subsp. hydrophila ATCC 7966

100

ML

92 97

ZP 08520118.1|Aeromonas caviae Ae398 YP 001142651.1|Aeromonas salmonicida subsp. salmonicida A449

YP 004393364.1|Aeromonas veronii B565 ZP 10135350.1|Cellvibrio sp. BR 97

YP 001981838.1|Cellvibrio japonicus Ueda107 ZP 01894623.1|Marinobacter algicola DG893 ZP 01735697.1|Marinobacter sp. ELB17

100

ZP 09160383.1|Marinobacter manganoxydans MnI7-9 YP 960732.1|Marinobacter aquaeolei VT8

91 100

YP 005431247.1|Marinobacter hydrocarbonoclasticus ATCC 49840

ZP 09251637.1|Acaryochloris sp. CCMEE 5410 100

YP 001514707.1|Acaryochloris marina MBIC11017 RfeI1 p73 Rfe p74 100

Rfe pd41

0.2

Plasmids

Figure A128. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

63 YP 457748.1|Erythrobacter litoralis HTCC2594

NJ

99

ZP 08701857.1|Citromicrobium sp. JLT1363

100

YP 457059.1|Erythrobacter litoralis HTCC2594

100 77 63

ZP 01039314.1|Erythrobacter sp. NAP1

ZP 06861577.1|Citromicrobium bathyomarinum JL354

ZP 01304686.1|Sphingomonas sp. SKA58 ZP 01451142.1|Mariprofundus ferrooxydans PV-1

70

gi|254674176|emb|CBA09960.1|Neisseria meningitidis alpha275 YP 008437.1|Candidatus Protochlamydia amoebophila UWE25 Reis3 p37

100

Rra2 p078

Plasmids

ZP 08778724.1|Candidatus Odyssella thessalonicensis L13 100

ZP 08778984.1|Candidatus Odyssella thessalonicensis L13

0.2

66 YP 457748.1|Erythrobacter litoralis HTCC2594 95

ZP 01039314.1|Erythrobacter sp. NAP1 ZP 08701857.1|Citromicrobium sp. JLT1363

ML

99 100

76

ZP 06861577.1|Citromicrobium bathyomarinum JL354 YP 457059.1|Erythrobacter litoralis HTCC2594

ZP 01304686.1|Sphingomonas sp. SKA58 ZP 01451142.1|Mariprofundus ferrooxydans PV-1 gi|254674176|emb|CBA09960.1|Neisseria meningitidis alpha275 YP 008437.1|Candidatus Protochlamydia amoebophila UWE25 100

Reis3 p37 Rra2 p078

71

Plasmids

ZP 08778724.1|Candidatus Odyssella thessalonicensis L13 99

0.2

ZP 08778984.1|Candidatus Odyssella thessalonicensis L13

Figure A129. Neighbor-joining (NJ) and maximum likelihood (ML) trees of lon ATPdependent protease. Bootstrap supports higher than or equal to 60% are shown on the branches.

67 Rph0772 86

NJ

RriSh0866 Rpe0113 Rel0773

97

Rja0757 Raf0840

Rpa0774 88 79 Rsi246 0082 Rco 710 Rsl 733 95

Rmo850058-59 Rra1027

94 100

Rrh0882 Rma 0774 Rhe1192 Reis1265

62

Rfe0882 76 10087

Rak0819 Rau1060 Rca0766 RprME0530

100 100

Rty0571 RbeOSU1146

100 100

RbeRML0975 OtsBo1202 100

97

OtsIk2297

YP 190537.1|Gluconobacter oxydans 621H

100

ZP 09093649.1|Gluconobacter morbifer G707

68

ZP 09953003.1|Sphingomonas elodea ATCC 31461 68

YP 001533120.1|Dinoroseobacter shibae DFL 12

100

YP 545520.1|Methylobacillus flagellatus KT YP 004427681.1|Alteromonas macleodii str. Deep ecotype

100

ZP 10288435.1|Pseudoalteromonas piscicida JCM 20779

100 100

ZP 10296065.1|Pseudoalteromonas rubra ATCC 29570 YP 003505509.1|Denitrovibrio acetiphilus DSM 12809 YP 005269850.1|Acetobacterium woodii DSM 1030

100 100

YP 003961446.1|Eubacterium limosum KIST612 ZP 07920366.1|Pseudoramibacter alactolyticus ATCC 23263

65

ZP 08707960.1|Peptoniphilus sp. oral taxon 375 str. F0436 ZP 02094882.1|Parvimonas micra ATCC 33270 YP 001921996.1|Clostridium botulinum E3 str. Alaska E43 ZP 09204293.1|Clostridium sp. DL-VIII

100 100

YP 001308466.1|Clostridium beijerinckii NCIMB 8052 ZP 09548682.1|Caldithrix abyssi DSM 13497

100

YP 004626254.1|Thermodesulfatator indicus DSM 15286

100

YP 004604093.1|Flexistipes sinusarabici DSM 4947 100

YP 004051703.1|Calditerrivibrio nitroreducens DSM 19672 ZP 08005871.1|Bacillus sp. 2 A 57 CT2

100 65

100

YP 004096107.1|Bacillus cellulosilyticus DSM 2522 NP 692997.1|Oceanobacillus iheyensis HTE831 YP 002460809.1|Desulfitobacterium hafniense DCB-2

100 79

97

ZP 09639765.1|Desulfitobacterium dichloroeliminans LMG P-21439 YP 003641298.1|Thermincola potens JR YP 001513703.1|Alkaliphilus oremlandii OhILAs YP 003851507.1|Thermoanaerobacterium thermosaccharolyticum DSM 571

97

YP 001663898.1|Thermoanaerobacter sp. X514

100 100

YP 003676446.1|Thermoanaerobacter mathranii subsp. mathranii str. A3

Rra2 p050 Rfe p36

100 100

0.1

RfeI1 p38

Pla smids

Rpa0774 76

Rsi246 0082 Raf0840 Rco 710 Rsl 733

88 97 Rel0773

Rja0757 Rpe0113

ML

88 84 Rph0772 63 RriSh0866

Rmo850058-59 Rra1027 Rrh0882 100

Rma 0774 Reis1265 Rfe0882 Rhe1192 Rak0819

90 Rau1060 100

RprME0530 100

100

Rty0571 Rca0766

RbeOSU1146

100 100

RbeRML0975 OtsBo1202 100

OtsIk2297

75

YP 190537.1|Gluconobacter oxydans 621H

100

ZP 09093649.1|Gluconobacter morbifer G707

91

ZP 09953003.1|Sphingomonas elodea ATCC 31461 75

YP 001533120.1|Dinoroseobacter shibae DFL 12

94

YP 545520.1|Methylobacillus flagellatus KT YP 004427681.1|Alteromonas macleodii str. Deep ecotype

100

ZP 10288435.1|Pseudoalteromonas piscicida JCM 20779

100 100

ZP 10296065.1|Pseudoalteromonas rubra ATCC 29570 ZP 09548682.1|Caldithrix abyssi DSM 13497

100

YP 004626254.1|Thermodesulfatator indicus DSM 15286

98

YP 004604093.1|Flexistipes sinusarabici DSM 4947 100

YP 004051703.1|Calditerrivibrio nitroreducens DSM 19672 ZP 08005871.1|Bacillus sp. 2 A 57 CT2

100 100

YP 004096107.1|Bacillus cellulosilyticus DSM 2522 NP 692997.1|Oceanobacillus iheyensis HTE831 YP 002460809.1|Desulfitobacterium hafniense DCB-2

75 100

ZP 09639765.1|Desulfitobacterium dichloroeliminans LMG P-21439

YP 003641298.1|Thermincola potens JR YP 001663898.1|Thermoanaerobacter sp. X514

100 100

YP 003676446.1|Thermoanaerobacter mathranii subsp. mathranii str. A3

85

YP 003851507.1|Thermoanaerobacterium thermosaccharolyticum DSM 571 YP 001513703.1|Alkaliphilus oremlandii OhILAs ZP 09204293.1|Clostridium sp. DL-VIII

100 100

YP 001308466.1|Clostridium beijerinckii NCIMB 8052 YP 001921996.1|Clostridium botulinum E3 str. Alaska E43 ZP 08707960.1|Peptoniphilus sp. oral taxon 375 str. F0436 ZP 02094882.1|Parvimonas micra ATCC 33270 ZP 07920366.1|Pseudoramibacter alactolyticus ATCC 23263 YP 005269850.1|Acetobacterium woodii DSM 1030

100 99

YP 003961446.1|Eubacterium limosum KIST612

YP 003505509.1|Denitrovibrio acetiphilus DSM 12809 Rra2 p050 Rfe p36

100 100

0.2

RfeI1 p38

Plasmids

Figure A130. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ YP 424886.1|Escherichia coli 95 gi|389556478|gb|EIM65625.1|Escherichia coli O157:H43 str. T22 100

ZP 06658956.1|Escherichia coli B185 gi|323964477|gb|EGB59953.1|Escherichia coli M863

97

YP 001393405.1|Yersinia pseudotuberculosis IP 31758 99

NP 783716.1|Yersinia enterocolitica YP 998100.1|Verminephrobacter eiseniae EF01-2

100 76

YP 001427365.1|Pseudomonas aeruginosa NP 942638.1|Xanthomonas citri 96 ZP 06704843.1|Xanthomonas fuscans str. ICPB 11122

Reis1 p10

Plasmid

0.1

57 gi|389556478|gb|EIM65625.1|Escherichia coli O157:H43 str. T22 97 ZP 06658956.1|Escherichia coli B185

ML

100

YP 424886.1|Escherichia coli gi|323964477|gb|EGB59953.1|Escherichia coli M863

80

YP 001393405.1|Yersinia pseudotuberculosis IP 31758 94

NP 783716.1|Yersinia enterocolitica

93 NP 942638.1|Xanthomonas citri

ZP 06704843.1|Xanthomonas fuscans str. ICPB 11122 100 YP 001427365.1|Pseudomonas aeruginosa

YP 998100.1|Verminephrobacter eiseniae EF01-2 Reis1 p10

0.1

Plasmid

Figure A131. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ YP 003292163.1|Escherichia coli 100

gi|339418364|gb|AEJ60032.1|Escherichia coli UMNF18 ZP 07171363.1|Escherichia coli MS 175-1 gi|345499161|emb|CCD10852.1|Shigella sp. MO17

ZP 08039170.1|Serratia symbiotica str. Tucson Raf p06

Plasmid

0.2

ML

YP 003292163.1|Escherichia coli 100

gi|339418364|gb|AEJ60032.1|Escherichia coli UMNF18 ZP 07171363.1|Escherichia coli MS 175-1 gi|345499161|emb|CCD10852.1|Shigella sp. MO17

ZP 08039170.1|Serratia symbiotica str. Tucson Raf p06

0.1

Plasmid

Figure A132. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conserved protein of unknown function. Bootstrap supports higher than or equal to 60% are shown on the branches.

ZP 07676205.1|Ralstonia sp. 5 7 47FAA

NJ

99

YP 001900315.1|Ralstonia pickettii 12J YP 002982301.1|Ralstonia pickettii 12D

100

NP 520617.1|Ralstonia solanacearum GMI1000

87 71

YP 003751629.1|Ralstonia solanacearum PSI07

YP 004976636.1|Burkholderia sp. YI23 ZP 01364243.1|Pseudomonas aeruginosa PACS2 100

NP 249558.1|Pseudomonas aeruginosa PAO1 Rra2 p091 100 Rhe p16

Plasmids

0.2

YP 001900315.1|Ralstonia pickettii 12J

ML 87

YP 002982301.1|Ralstonia pickettii 12D ZP 07676205.1|Ralstonia sp. 5 7 47FAA

96

NP 520617.1|Ralstonia solanacearum GMI1000

78 63

YP 003751629.1|Ralstonia solanacearum PSI07 YP 004976636.1|Burkholderia sp. YI23

ZP 01364243.1|Pseudomonas aeruginosa PACS2 100 NP 249558.1|Pseudomonas aeruginosa PAO1

Rra2 p091 100 Rhe p16

0.2

Plasmids

Figure A133. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase. Bootstrap supports higher than or equal to 60% are shown on the branches.

73 YP 877069.1|Clostridium novyi NT

NJ

99

YP 879171.1|Clostridium novyi NT YP 004396686.1|Clostridium botulinum BKT015925

73 YP 004396240.1|Clostridium botulinum BKT015925

YP 005471888.1|Fervidobacterium pennivorans DSM 9078 ZP 08213611.1|Thermoanaerobacter ethanolicus JW 200

88

99 ZP 08213129.1|Thermoanaerobacter ethanolicus JW 200

Rfe p90 Rfe pd57 100

Plasmids

RfeI1 p92

0.1

79 YP 877069.1|Clostridium novyi NT

ML

100

YP 879171.1|Clostridium novyi NT YP 004396686.1|Clostridium botulinum BKT015925 YP 004396240.1|Clostridium botulinum BKT015925 YP 005471888.1|Fervidobacterium pennivorans DSM 9078

83

ZP 08213611.1|Thermoanaerobacter ethanolicus JW 200 97 ZP 08213129.1|Thermoanaerobacter ethanolicus JW 200

Rfe p90 Rfe pd57 100

RfeI1 p92

0.1

Plasmids

Figure A134. Neighbor-joining (NJ) and maximum likelihood (ML) trees of transposase containing DDE_Tnp_1_3 domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

61 ZP 08975270.1|Cyanothece sp. ATCC 51472 98

NJ

CCI38498.1|Microcystis aeruginosa PCC 9701

72

YP 001801678.1|Cyanothece sp. ATCC 51142 YP 005443276.1|Caldilinea aerophila DSM 14535 NBRC 104270

73

YP 006295492.1|Methylophaga sp. JAM1 100

YP 006296858.1|Methylophaga sp. JAM1 YP 006297215.1|Methylophaga sp. JAM1

YP 001393970.1|Clostridium kluyveri DSM 555

99

YP 003781042.1|Clostridium ljungdahlii DSM 13528 NP 484634.1|Nostoc sp. PCC 7120

71

YP 004775247.1|Cyclobacterium marinum DSM 745 60

YP 001928223.1|Porphyromonas gingivalis ATCC 33277 ZP 06253809.1|Prevotella copri DSM 18205 ZP 06407470.1|Prevotella melaninogenica D18

97

YP 006299425.1|Prevotella intermedia 17

96 92 63

ZP 08172564.1|Prevotella denticola CRIS 18C-A ZP 07883595.1|Prevotella buccae ATCC 33574 ZP 10826039.1|Prevotella sp. MSX73

ZP 03335692.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB 100 ZP 03335693.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB

Plasmid

Rmo p32 100

OtsIk0349 OtsIk2708

100 ref|NW 002061028.1 1 Trichoplax adhaerens strain Grell-BS-1999

ref|NW 002061028.1 2 Trichoplax adhaerens strain Grell-BS-1999 Rrh0811 80 RmaB0376 100

RmaB0747 65 Rrh0278

61

Rrh1640 Reis0056 Reis0135 94

Reis0256 Reis0306 Reis2346

0.1

ZP 07883595.1|Prevotella buccae ATCC 33574

ML 70

ZP 10826039.1|Prevotella sp. MSX73 YP 006299425.1|Prevotella intermedia 17

96

ZP 08172564.1|Prevotella denticola CRIS 18C-A 96

ZP 06407470.1|Prevotella melaninogenica D18 ZP 06253809.1|Prevotella copri DSM 18205

72

YP 001393970.1|Clostridium kluyveri DSM 555 YP 003781042.1|Clostridium ljungdahlii DSM 13528 NP 484634.1|Nostoc sp. PCC 7120

70

YP 004775247.1|Cyclobacterium marinum DSM 745 YP 001928223.1|Porphyromonas gingivalis ATCC 33277 YP 006295492.1|Methylophaga sp. JAM1 100

YP 006297215.1|Methylophaga sp. JAM1 YP 006296858.1|Methylophaga sp. JAM1

YP 005443276.1|Caldilinea aerophila DSM 14535 NBRC 104270 CCI38498.1|Microcystis aeruginosa PCC 9701

80

ZP 08975270.1|Cyanothece sp. ATCC 51472

88

YP 001801678.1|Cyanothece sp. ATCC 51142 ZP 03335692.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB 100 ZP 03335693.1|Wolbachia endosymbiont of Culex quinquefasciatus JHB

Rmo p32

Plasmid 100

OtsIk0349 OtsIk2708

100 ref|NW 002061028.1 1 Trichoplax adhaerens strain Grell-BS-1999 TRIADscaffold 92

ref|NW 002061028.1 2 Trichoplax adhaerens strain Grell-BS-1999 TRIADscaffold 92 Rrh0811 64 90 RmaB0376 98

RmaB0747 72 Rrh0278

Rrh1640 Reis0056 Reis0135 90

Reis0256 Reis0306 Reis2346

0.1

Figure A135. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraK domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ

Reis3 p27 Rra2 p059-60

Plasmids

ZP 08778785.1|Candidatus Odyssella thessalonicensis L13

0.2

ML Reis3 p27 Rra2 p059-60

Plasmids

ZP 08778785.1|Candidatus Odyssella thessalonicensis L13

0.2

Figure A136. Neighbor-joining (NJ) and maximum likelihood (ML) trees of conjugative transfer protein containing TraK domain. Bootstrap supports higher than or equal to 60% are shown on the branches.

NJ 100

Reis3 p26 Rra2 p058

Plasmids

ZP 08701870.1|Citromicrobium sp. JLT1363 YP 457761.1|Erythrobacter litoralis HTCC2594

0.2

ML 100

Reis3 p26 Rra2 p058

Plasmids

ZP 08701870.1|Citromicrobium sp. JLT1363 YP 457761.1|Erythrobacter litoralis HTCC2594

0.2