Fibroblast growth factor receptor (fms-related tyrosine kinase 2, Pfeiffer syndrome) ... Matrix metalloproteinase 9 (gelatinase B, 92kDa type IV collagenase).
Anti-angiogenic activity and pharmacogenomics of medicinal plants from traditional Korean medicine
Ean-Jeong Seo*, Victor Kuete*, Onat Kadioglu, Benjamin Krusche, Mira Oswald, Sven Schröder, Henry Johannes Greten, Joachim Arend, Ik-Soo Lee, Thomas Efferth ----------------------------------Suppleme ntary Table: Genes involved in angiogenesis (taken from: Peale Jr FV, Gerritsen ME. Gene profiling techniques and their application in angiogenesis and vascular development. J Pathol 2001; 195: 7–19.
Gene Symbol TIMP3 THBS4 HGF HGF THBS1 ACTG2 AXL FGFR2 FGFR2 TIMP2 EphA2 SST TEK BMB6 TGFB2 NOS2A VEGF VEGF NOS3 FGFR1 FGFR1 CD44 SSP1 SSP1
Pattern ID Genbank Accession GC19231 AA043969 GC15218 N80868 GC14697 N62083 GC17092 AA037786 GC10044 AA056585 GC9740 AA053297 GC11900 T91043 GC10638 R38513 GC17772 W87790 GC15806 W49722 GC17968 AA001368 GC16150 W72209 GC12925 H44411 GC12254 R27799 GC14551 N48082 GC13640 H67843 GC15550 W19225 GC9897 AA045836 GC12213 GC10555 GC12641 GC11989 GC13722 GC16786
R21248 T66144 R54846 T91563 H93048 AA021512
SELE
GC12936 GC12293
H39991 R36451
GC12570 GC15675 GC10483
H03907 W15432 AA057805
GC11583 GC10023 GC9808 GC18383 GC18944 GC14622 GC13080 GC15271 GC17776
T41204 AA056542 AA044829 AA030000 AA040443 N71935 R94927 N79985 W89129
FN1 FN1 FN1 FN1 MMP9 COL1A2 COL3A1 EFEMP1 EFEMP1 MPDZ ARG2 TRB PLAT
Gene Name Tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, pseudoinflammatory) Thrombospondin 4 Hepatocyte growth factor (hepapoietin A; scatter factor) Hepatocyte growth factor (hepapoietin A; scatter factor) Thrombospondin 1 actin, 2, smooth muscle, enteric AXL receptor tyrosine kinase Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 2 Tissue inhibitor of metalloproteinase 2 Ephrin A2 Somatostatin TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) Bone morphogenetic protein 6 Transforming growth factor, 2 Nitric oxide synthase 2A Vascular endothelial growth factor Vascular endothelial growth factor Nitric oxide synthase 3 Fibroblast growth factor receptor (fms-related tyrosine kinase 2, Pfeiffer syndrome) Fibroblast growth factor receptor (fms-related tyrosine kinase 2, Pfeiffer syndrome) CD44 antigen (homing function and Indian blood group system) Secreted phosphoprotein 1 (osteopontin, bone sialoprotein, early T-lymphocyte activation 1) Secreted phosphoprotein 1 (osteopontin, bone sialoprotein, early T-lymphocyte activation 1) Selectin E (endothelial adhesion molecule 1) Fibronectin 1 Fibronectin 1 Fibronectin 1 Fibronectin 1 Matrix metalloproteinase 9 (gelatinase B, 92kDa type IV collagenase) Collagen, typeI,2 collagen, type III, 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) EGF-containing fibulin-like extracellular matrix protein 1 EGF-containing fibulin-like extracellular matrix protein 1 Multiple PDZ domain protein Arginase, type II T-cell receptor locus Plas minogen activator, tissue
1
ADM PIN C1QR1 IL8 COL1A1 MMRN F3 SPARCL1 CTGF COL4A2 MGP CHD5 NRCAM NRCAM PLAU TFPI2 TFPI2 PECAM1 PECAM1 ANGPTL2 IL6ST HPN COL18A1 SNX17 MDK SERPINE1 MMP11 MMP11 FST DDAH2 CD34 NOTCH3 CYR61 PML PML PML MMP2 NOTCH4 C6orf9 BST2 ITGA5 THY1 THY1 BMP1 BMP1 M11S1 COL5A1 BMPR2 INHBA GJA4 DVL3 DVL3 STC1 ABCG1 TGFB1 FGF2 FGF2 FGFR2 FGFR2 EDG1 CXCR4 NID2 PGF
GC16644 GC18907 GC19150 GC15899 GC17894 GC16095 GC12286 GC18568 GC19343 GC10048 GC16120 GC13933 GC10822 GC14758 GC19033 GC16650 GC18167 GC11837 GC10029 GC16029 GC13860 GC13241 GC16530 GC10384 GC16107 GC19310 GC18601 GC15801 GC12080 GC15208 GC13318 GC18151 GC19161 GC12650 GC15315 GC17137 GC12462 GC16035 GC11019 GC12646 GC16514 GC12929 GC18445 GC12413 GC17017 GC16436 GC18776 GC13867 GC14152 GC15957 GC16240 GC19142 GC12616 GC13298 GC12433 GC15733 GC15826 GC10638 GC17772 GC15407 GC12441 GC16008 GC18503
AA017304 AA040248 AA044236 W45324 W90360 W73053 R34833 AA033762 AA044993 AA056692 W72057 N22448 R45583 N59824 AA040727 AA017446 AA011474 T72992 AA056412 W73148 H85457 GC13241 AA009987 AA053676 W72586 AA046659 AA034203 W49497 R01927 N81116 H72113 AA007598 AA044574 R55296 N93133 AA039542 R79223 W74767 R59617 R54976 W92322 H28104 AA031264 R71212 AA029677 W94794 AA037002 H96519 N27159 W69079 W79440 AA044175 R48580 H68928 R76212 W44678 W52295 R38513 W87790 N93476 R78620 W70102 AA031377
Adrenomedullin Dynein, cytoplasmic, light polypeptide Complement component 1, q subcomponent, receptor 1 Interleukin 8 Collagen, type I, 1 Multimerin Coagulation factor III (thromboplastin, tissue factor) SPARC.like 1 (mast9, hevin) Connective tissue growth factor Collagen, type IV, 2 Matrix Gly protein Cadherin 5, type 2, VE-cadherin (vascular epithelium) Neuronal cell adhesion molecule Neuronal cell adhesion molecule Plas minogen activator, urokinase Tissue factor pathway inhibitor 2 Tissue factor pathway inhibitor 2 Platelet/endothelial cell adhesion molecule (CD31 antigen) Platelet/endothelial cell adhesion molecule (CD31 antigen) Angiopoietin-like 2 Interleukin 6 signal transducer (gp130, oncostatin M receptor) Hepsin (transmembrane protease, seine 1) Collagen, type XVIII, 1 Sorting nexin 17 Midkine (neurite growth-pro,moting factor 2) Serine (or cys) proteinase inhibibitor, clase E (nexin, plasminogen activator inhibitor type 1), 1 Matrix metalloproteinase 1 (stromyelysin 3) Matrix metalloproteinase 1 (interstitial collagenase) Follistatin Dimethylarginine dimethylaminohydolase 2 CD34 antigen Notch homologue 3 (Drosophila) Cystene-rich, angiogenic inducer, 61 Promyelocytic leukemia Promyelocytic leukemia Promyelocytic leukemia Matrix metalloproteinase 2 (gelatinase A, 72kDa type IV collagenase) Notch homologue 4 (Drosophila) Chromosome 6 open reading frame 9 Bone marrow stromal cell antigen 2 Integrin, 5 (fibronectin receptor, poly peptide) Thy-1 cell surface antigen Thy-1 cell surface antigen Bone morphognetic protein 1 Bone morphognetic protein 1 Membrane compenent, chromosome 11, surface marker 1 Collagen, type V, 1 Bone morphognetic protein receptor, type II (serine/threonine kinase) inhibin, A (activ in AB a polypeptide) Gap junction protein,4, 37kDa (connecin 37) Dishevelled, dsh homologue 3 (Drosophila) Dishevelled, dsh homologue 3 (Drosophila) Stanniocalcin 1 ATP-binding cassette, subfamily G (WHITE), member 1 Transforming growth factor 1 Fibroblast growth factor 2 (basic) Fibroblast growth factor 2 (basic) Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 2 Endothelial differentiation, spingolipid G-protein-coupled receptor 1 Chemokine (C-X-C motif), receptor 4 (fusin) Nidogen 2 Placental grow th factor, vascular endothelial growth factor-related protein
2
MCAM MCAM SPR VEGFB VEGFC FLT1 ANGPTL3 HIF1A ANG
GC12722 GC19206 GC16989 GC18978 GC15494 GC14477 GC11804 GC15805 GC18183
H28333 AA042901 AA026314 AA040199 N94399 N47214 T73442 W47003 AA011614
Melanoma cell adhesion molecule Melanoma cell adhesion molecule Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase Vascular endothelial growth factor B Vascular endothelial growth factor C Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor Angiopoietin-like 3 Hypoxia-inducible factor 1, subunit (basic helix-loop-helix transcription factor) Angiogenin, ribonuclease, RNase A family, 5
3
