Apr 15, 2014 - An oral glucose tolerance test (OGTT) was also performed on the diabetic ... grinder mill. .... and 3 h after glucose load (Sellamuthu et al., 2009).
Vol. 9(7), pp. 204-212, 15 April, 2014 DOI: 10.5897/SRE2014.5824 Article Number: BF31E5A43777 ISSN 1992-2248 Copyright©2014 Author(s) retain the copyright of this article http://www.academicjournals.org/SRE
Scientific Research and Essays
Full Length Research Paper
Antidiabetic activity and phytochemical screening of Acalypha wilkesiana (Euphorbiaceae) Mull Arg. roots in alloxan-induced diabetic rats Odoh U. E.1*, Ndubuokwu R. I.1, Inya- Agha S. I.1, Osadebe P. O.2, Uzor P. F.2 and Ezejiofor M.1 1
Department of Pharmacognosy and Environmental Medicines, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria. 2 Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria. Received 28 January, 2014; Accepted 25 February, 2014
The aim of this study was to investigate the anti-diabetic effects and biochemical parameters of methanol root extract of Acalypha wilkesiana Mull Arg. (MEAW) in alloxan-induced diabetic rats. The effect of the extract (200 and 400 mg/kg, p.o.) on fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) level and liver glycogen content were investigated in alloxan-induced diabetic rats after 14 days. An oral glucose tolerance test (OGTT) was also performed on the diabetic rats. Dose selection was made on the basis of acute oral toxicity study. Phytochemical analysis of the root extract was carried out following standard procedures. The most significant (p
