with standard drug phenformin. The hydromethanolic extract and its fractions were subjected to preliminary qualitative chemical investigations which indicated ...
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All the capsules were found to be ßoating for more than 12 h. The drug content in the capsules of each formulation was found within the range of 90-110 percent as specified for theophylline capsules IP8, which confirms to show an excellent drug content uniformity in each formulation (Table 3). All the formulations confirmed to the general pharmacopoeial requirement of not more than ±7.5 % deviation9. Capsules of all formulations showed an excellent uniformity in their weights. In vitro drug release studies from formulation 1-4 showed the release of 76.54%, 75.10%, 66.04% and 70.05% which clearly conÞrm that formulation 1 containing HPMC: MC:HEC: Na-CMC in the proportion of 2:1.5:1:0.5 exhibited better release from the capsules ((Þg. 1), Table 4)
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ACKNOWLEDGEMENTS
Accepted 5 April 2008 Revised 18 September 2007 Received 23 May 2006 Indian J. Pharm. Sci., 2008, 70 (2): 224-227
Authors are thankful to Nucron Pharmaceuticals, Pune for the gift sample of theophylline.
Antihyperglycemic Activity of Various Fractions of Cassia auriculata Linn. in Alloxan Diabetic Rats S. J. SURANA, S. B. GOKHALE, R. B. JADHAV, R. L. SAWANT AND JYOTI B. WADEKAR* P. D. V. V. P. F’s College of Pharmacy, Vilad Ghat, Post MIDC, Ahmednagar-414 111, India
Surana, et al.: Antihyperglycemic Activity of Cassia auriculata Linn. in Diabetic Rats Present work describes the potent antidiabetic fraction from flowers of Cassia auriculata Linn. Hydromethanolic extract along with its ethyl acetate and n-butanol fractions were evaluated for antidiabetic activity in alloxan-induced diabetes in rats. The n-butanol fraction exhibited significant reduction (p
