Ann Hematol (2003) 82 (Suppl 2):S105–S117 DOI 10.1007/s00277-003-0764-4
H. Link · A. Bhme · O. A. Cornely · K. Hffken · O. Kellner · W. V. Kern · R. Mahlberg · G. Maschmeyer · M. R. Nowrousian · H. Ostermann · M. Ruhnke · O. Sezer · X. Schiel · M. Wilhelm · H. W. Auner
Antimicrobial therapy of unexplained fever in neutropenic patients Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO), Study Group Interventional Therapy of Unexplained Fever, Arbeitsgemeinschaft Supportivmassnahmen in der Onkologie (ASO) of the Deutsche Krebsgesellschaft (DKG—German Cancer Society) Published online: 9 September 2003 Springer-Verlag 2003
H. Link ()) Dept. of Internal Medicine I (Head: H. Link), Medizinische Klinik I, Westpfalz-Klinikum, Hellmut-Hartert-Strasse 1, 67655 Kaiserslautern, Germany e-mail:
[email protected] Tel.: +49-631-2031260 Fax: +49-631-2031548 K. Hffken Dept. of Internal Medicine II (Head: K. Hffken), Friedrich Schiller University, Jena, Germany A. Bhme Dept. of Internal Medicine III (Head: D. Hoelzer), University Hospital, Frankfurt/Main, Germany O. A. Cornely Dept. of Internal Medicine I (Head: V. Diehl), University of Cologne, Kln, Germany O. Kellner Dept. of Internal Medicine IV (Head: H. Schmoll), Oncology-Hematology, Martin Luther University, Halle, Germany W. V. Kern Dept. Internal Medicine II, Infectiology, University Medical Center, Freiburg, Germany R. Mahlberg Dept. of Internal Medicine I, Mutterhaus der Borromerinnen (Head: M. Clemens), Trier, Germany
G. Maschmeyer Dept. of Internal Medicine, Hematology and Oncology (Head: B. Drken), University Medical Center Charit, Campus Virchow-Klinikum, Humboldt University, Berlin, Germany M. R. Nowrousian Dept. of Internal Medicine, (Head: S. Seeber), University Medical Center, Essen, Germany H. Ostermann · X. Schiel Dept. of Internal Medicine III (Head: W. Hiddemann), University Medical Center Grosshadern, Ludwig Maximilian University, Mnchen, Germany M. Ruhnke · O. Sezer Dept. of Internal Medicine II, University Medical Center Charit (Head: K. Possinger), Berlin, Germany M. Wilhelm Dept. of Internal Medicine V (Head: M. Wilhelm), Klinikum Nrnberg Nord, Nrnberg, Germany H. W. Auner Division of Hematology (Head: W. Linkesch), Karl-Franzens University Hospital, Graz, Austria
Abstract Cytostatic chemotherapy of hematological malignancies is often complicated by neutropenia, which increases the risk of infections, especially if the neutrophil count is below 500/ml. Frequently, fever is the first, and in most patients the only, sign of an infection. Unexplained fever is defined as follows: temperature of 38.3C or
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38.0C for at least 1 h, or measured twice within 12 h, if the neutrophil count is
