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Antiretroviral therapy is not associated with reduced herpes simplex virus shedding in HIV coinfected adults: an observational cohort study Darrell H S Tan,1,2,3,4 Janet M Raboud,2,5 Rupert Kaul,2,3 Sharon L Walmsley2,3,4
To cite: Tan DHS, Raboud JM, Kaul R, et al. Antiretroviral therapy is not associated with reduced herpes simplex virus shedding in HIV coinfected adults: an observational cohort study. BMJ Open 2014;4:e004210. doi:10.1136/bmjopen-2013004210 ▸ Prepublication history for this paper is available online. To view these files please visit the journal online (http://dx.doi.org/10.1136/ bmjopen-2013-004210). Received 9 October 2013 Revised 1 November 2013 Accepted 5 November 2013
For numbered affiliations see end of article. Correspondence to Dr Darrell H S Tan;
[email protected]
ABSTRACT Objectives: Herpes simplex virus types 1 and 2 (HSV-1/2) may have adverse consequences on HIV type 1 infection. We quantified the frequency of HSV reactivations in highly active antiretroviral therapy (HAART)-treated adults with HIV, and compared it with that in HAART-naïve patients. Setting: 2 academic hospital sites in Toronto, Canada. Participants: Asymptomatic HAART-naive (n=44) or treated (with HIV RNA
