Nov 23, 2006 - Badajoz, Spain; Armando Perez de Prado, Hospital de Leon, Leon, Spain; Francisco. Fernandez-Aviles, ICICOR, Hospital Clinico Valladolid, ...
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Print This Page Meeting:
Scientific Sessions 2003
Session Number:
AOP.48.3
Session Title:
Catheter-Based Management of Acute Coronary Syndromes
Presentation 2148 Number: Presentation Effect of Early Posthrombolysis Stenting Versus Conservative Approach to STEAMI on Title: One-Year Angiographic Outcome. An Angiographic Substudy of the GRACIA-1 Trial Author Block:
Joaquin J Alonso, Federico Gimeno, Olga Sanz, ICICOR, Hospital Clinico Valladolid, Valladolid, Spain; Rosa Hernandez, Hospital San Carlos, Madrid, Spain; Isabel Calvo, Hospital Miguel Servet, Zaragoza, Spain; Antonio Merchan, Hospital Infanta Cristina, Badajoz, Spain; Armando Perez de Prado, Hospital de Leon, Leon, Spain; Francisco Fernandez-Aviles, ICICOR, Hospital Clinico Valladolid, Valladolid, Spain; GRACIA-1 Trial
Disclosure Block:
J.J. Alonso, None; F. Gimeno, None; O. Sanz, None; R. Hernandez, None; I. Calvo, None; A. Merchan, None; A. Perez de Prado, None; F. Fernandez-Aviles, None.
Abstract Body:
Background: Observational data support the hypothesis that infarct-related artery patency independently benefits prognosis. However, randomised data are scant regarding the effect of early postinfarction intervention on long-term culprit artery permeability, myocardial perfusion, and left ventricular evolution or clinical outcome. Methods: To study the effect of early after thrombolysis (T) stenting of the culprit artery on long-term permeability and left ventricular outcome, we carried out an angiographic substudy of the GRACIA-1 trial that compared the one-year angiographic evolution of the 171 patients included. Eighty patients were randomly assigned to post-T ischemia-guided conservative approach (age 61.9±10 years, 88% male) and 91 pts randomised to undergo stenting within 24 hours of T (mean 15.6±5.9 hours, range: 6 to 23 hours). Angiographic evaluation was carried out by an independent core laboratory. Results: Both groups of pts had similar demographic and clinical profile. Infarct location and number of vessels with significant stenosis were also similar. One year angiography showed higher incidence of normal flow (TIMI corrected frame count grade 3) among pts allocated to intervention (90% vs 62%, p
