gamoyenebis instruqcia asibroqsi. ASIBROX. savaWro dasaxeleba asibroqsi,
ASIBROX. saerTaSoriso aradapatentebuli dasaxeleba acetilcisteini ...
gamoyenebis instruqcia asibroqsi ASIBROX savaWro dasaxeleba asibroqsi, ASIBROX saerTaSoriso aradapatentebuli dasaxeleba acetilcisteini, Acetylcysteine wamlis forma SuSxuna tabletebi.
aRweriloba: gluvcilindruli tabletebi TeTri feris nazoliT, dasaSvebia msubuqi gaumWvirvaloba, damaxasiaTebeli suniT. Semadgenloba asibroqsi 200 mg 1 SuSxuna tableti Seicavs aqtiuri nivTiereba: acetilcisteini 200 mg damxmare nivTierebebi: askorbinis mJava, natriumis karbonati uwylo, natriumis hidrokarbonati, limonis mJava uwylo, sorbitoli, natriumis citrati, makrogoli 6000, natriumis saqarini, aromatizatori “limoni”. asibroqsi 600 mg 1 SuSxuna tableti Seicavs aqtiuri nivTiereba: acetilcisteini 600 mg damxmare nivTierebebi: askorbinis mJava, natriumis karbonati uwylo, natriumis hidrokarbonati, limonis mJava uwylo, sorbitoli, natriumis citrati, makrogoli 6000, natriumis saqarini, aromatizatori “limoni”. farmakoTerapiuli jgufi mukolizuri saSualeba, aTq kodi R05CB01. farmakologiuri Tvisebebi
farmakodinamika acetilcisteini – mukolizuri, amosaxvelebeli saSualeba, aminomJava cisteinis warmoebuli. Tavisufli sulfhidriluri jgufis arsebobis wyalobiT acetilcisteini wyvets kavSirs naxvelis mJava mukopolisaqaridebs Soris, rac iwvevs mukoproteidebis depolimerizacias da xels uwyobs bronquli sekretis webovanebis Semcirebas. acetilcisteini avlens mukolizur aqtivobas nebismieri tipis naxvelis mimarT – lorwovani, lorwovan-Cirqovani, Cirqovani. amsubuqebs naxvelis gamoyofas mukociliaruli klirensis momatebis xarjze. acetilcisteins SeuZlia bronqebis lorwovani garsis epiTelur ujredebze baqteriebis adheziis Semcireba, naxvelis webovanebis Semcirebisa da mukociliaruli klirensis gazrdis Sedegad. acetilcisteins agreTve gaaCnia antioqsidanturi da pnevmoproteqtoruli Tvisebebi (romlebic uzrunvelyofen sasunTqi organoebis efeqtur dacvas uaryofiTi faqtorebis toqsikuri zemoqmedebisagan, rogoricaa: anTebis metabolitebi, garemo faqtorebi, sigaretis kvamli, rac gapirobebulia sulfhidriluri jgufebis unariT moaxdinon Tavisufali radikalebis SekavSireba). garda amisa, acetilcisteini xels uwyobs glutaTionis sinTezis momatebas, romelic warmoadgens detoqsikaciis mniSvnelovan faqtors. acetilcisteinis es unari iZleva misi antidotis saxiT gamoyenebis saSualebas paracetamoliT da sxva nivTierebebiT (aldehidebiT, fenolebiT da sxv.) mwvave mowamvlisas. amgvarad uzrunvelyofilia filtvis qsovilebis ujredebis mTlianobis funqcionaluri aqtivobisa da morfologiuri mTlianobis SenarCuneba. acetilcisteinis mukolizuri Tvisebebi gamovlenas iwyebs Terapiis dawyebidan 1-2 dReSi. profilaqtikuri mizniT gamoyenebisas acetilcisteini amcirebs qronikuli bronqitisa da mukoviscidozis gamwvavebebis sixSiresa da simZimes.
farmakokinetika
Sinaganad miRebis Semdeg acetilcisteini swrafad da TiTqmis srulad absorbirdeba saWmlis momnelebel traqtSi. acetilcisteinis bioSeRwevadoba oraluri miRebis Semdeg Seadgens daaxloebiT 10%-s. maqsimaluri koncentracia miiRweva 1-3 saaTSi. RviZlSi metabolizdeba cisteinamde (farmakologiurad aqtiuri metaboliti) da diacetilcistinamde, cistinamde da Semdeg Sereul disulfidebamde. organizmSi acetilcisteini da misi metabolitebi ganisazRvreba sxvadasxva formebSi: nawilobriv – Tavisufali substanciebis saxiT, nawilobriv – sisxlis plazmis proteinebTan kavSirSi, nawilobriv – inkorporirebuli aminomJavebis saxiT. praqtikulad srulad eqskretirdeba araaqtiuri metabolitebis saxiT (araorganuli sulfatebi, diacetilcisteini) SardTan erTad. acetilcisteinis mxolod mcire raodenoba gamoiyofa ganavalTan erTad ucvleli saxiT. sisxlis plazmidan naxevargamoyofis periodi Seadgens daaxloebiT 1 saaTs da damokidebulia RviZlSi biotransformaciis siCqareze. RviZlis ukmarisobisas igi SeiZleba gaizardos 8 saaTamde. acetilcisteinma SeiZleba SeaRwios placentur barierSi da dagrovdes amnionur siTxeSi. gamoyenebis Cvenebebi sasunTqi organoebis daavadebebi, romlebsac Tan axlavs Znelad mosacilebeli webovani naxvelis momatebuli warmoqmna: - mwvave da qronikuli bronqitebi; - obstruqciuli bronqiti; - filtvis obstruqciuli emfizema; - laringotraqeiti; - pnevmonia; - bronqoeqtazebi; - bronquli asTma; - bronqiolitebi; - ateleqtazi, ganviTarebuli lorwovani sacobiT bronqebis dacobis Sedegad; - mukoviscidozi; - sekretis mocilebis Sesamsubuqeblad mwvave da qronikuli sinusitis, Sua otitis dros; - webovani naxvelis mocileba sasunTqi gzebidan posttravmuli da postoperaciuli mdgomareobebis dros, postoperaciuli respiratoruli garTulebebis profilaqtika da mkurnaloba. gamoyenebis wesi da dozireba asibroqsi miiReba SigniT. 600 mg acetilcisteinis Semcveli erTi tableti ixsneba 200 ml sasmel, oTaxis temperaturamde SemTbar wyalSi an 200 mg acetilcisteinis Semcveli erTi tableti ixsneba 100 ml sasmel, oTaxis temperaturamde SemTbar wyalSi. preparati miiReba Wamis Semdeg. siTxis damatebiT miReba aZlierebs acetilcisteinis mukolizur efeqts. miiReba gaxsnisTanave, gamonaklis SemTxvevebSi SeiZleba mza xsnaris gaCereba 2 saaTiT. mozrdilebsa da mozardebSi 14 wlis zemoT preparati iniSneba doziT 200 mg 2-3-jer dReSi an doziT 600 mg erTxel dReSi. 6-dan 14 wlamde asakis bavSvebSi rekomendebulia 200 mg-is miReba dReSi 2-jer. 2-dan 6 wlamde asakis bavSvebSi iniSneba 200 mg 1-jer dReSi. mukoviscidozis dros: - mozrdilebsa da mozardebSi 14 wlis asakis zemoT preparati iniSneba doziT 200 mg 23-jer dReSi an doziT 600 mg 1-jer dReSi. - 6 wlis zemoT asakis bavSvebSi rekomendebulia 200 mg-is miReba dReSi 3-jer. - 2-dan 6 wlamde asakis bavSvebSi iniSneba 200 mg 2-jer dReSi. - 30 kg-ze meti sxeulis masis mqone pacientebs SeuZliaT preparatis miReba doziT 800 mg dReSi. xanmokle gaciebis dros miRebis xangrZlivoba Seadgens 5-7 dRes. qronikuli bronqitebisa da mukoviscidozis dros infeqciis sawinaaRmdegod profilaqtikuri efeqtis misaRwevad preparatis miReba unda moxdes ufro xangrZlivi drois ganmavlobaSi an ramdenime Tviani kursebiT. ukuCvenebebi
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momatebuli mgrZnobeloba acetilcisteinisa da preparatis sxva komponentebis mimarT. kuWisa da Tormetgoja nawlavis wylulovani daavadeba gamwvavebis fazaSi.
gverdiTi moqmedeba centraluri nervuli sistemis mxriv: iSviaTad – Tavis tkivili, Suili yurebSi. saWmlis momnelebeli sistemis mxriv: iSviaTad – stomatiti; calkeul SemTxvevebSi – gulisreva, Rebineba, gulZmarva, diarea. gul-sisxlZarRvTa sistemis mxriv: calkeul SemTxvevebSi – arteriuli wnevis dacema, taqikardia. sasunTqi sistemis mxriv: calkeul SemTxvevebSi – filtvismieri sisxldenis ganviTareba, rogorc momatebuli mgrZnobelobis reaqciis gamovlineba. alergiuli reaqciebi: gamonayari kanze, qavili, WinWris cieba; calkeul SemTxvevebSi – bronqospazmi (upiratesad bronqebis hiperaqtiurobis mqone pacientebSi). gansakuTrebuli miTiTebebi asibroqsi sifrTxiliT gamoiyeneba sisxliani naxvelis, filtvismieri sisxldenisas, saylapavi milis venebis varikozuli gafarToebis mqone pacientebSi, Tirkmelzeda jirkvlis daavadebebis, RviZlis da/an Tirkmelebis ukmarisobis dros. bronquli asTmisa da obstruqciuli bronqitis dros acetilcisteini iniSneba sifrTxiliT bronquli gamtarobis sistematiuri kontroliT. axalSobilebSi acetilcisteinis daniSvna SeiZleba mxolod sasicocxlo CvenebiT da mkacri kontroliT (maqsimum 10 mg/kg sxeulis masaze). asibroqsi Seicavs sorbitols da natriumis saqarins, amitom preparatis gamoyenebamde, Saqriani diabetis mqone pacientebma konsultaciisTvis unda mimarTon eqims. preparatTan muSaobisas aucilebelia SuSis WurWlis gamoyeneba, liTonTan, rezinasTan, JangbadTan, iolad mJangav nivTierebebTan kontaqtis Tavidan acileba. zemoqmedeba avtomobilisa da sxva meqanizmebis marTvis unarze asibroqsi gavlenas ar axdens avtomobilis marTvis unarze da iseTi samuSaos Sesrulebaze, rac moiTxovs fsiqomotoruli reaqciebis maRal siswrafes. gamoyeneba orsulobisa da laqtaciis periodSi adekvaturi da kargad kontrolirebuli kvlevebi orsulobisa da laqtaciis preparatis gamoyenebis Sesaxeb ar Catarebula. aRniSnul periodSi asibroqsis miReba SeiZleba mxolod eqimis daniSnulebiT. gamoyeneba pediatriaSi preparati ukunaCvenebia 14 tabletebis SemTxvevaSi).
wlamde
asakis
bavSvebSi
(600
mg
acetilcisteinis
periodSi
Semcveli
urTierTqmedeba sxva samkurnalo saSualebebTan acetilcisteinisa da xvelis sawinaaRmdego saSualebebis erTdrouli gamoyenebisas xvelis refleqsis daTrgunvis gamo SeiZleba ganviTardes lorwos Segubeba. amitom amgvari kombinaciebis SerCeva unda moxdes sifrTxiliT. aRiniSneba acetilcisteinis sinergizmi bronqolzurebTan. acetilcisteinisa da nitroglicerinis erTdroulma miRebam SeiZleba gamoiwvios am ukanasknelis sisxlZarRvebis gamafarToebeli efeqtis gaZliereba. farmakologiurad SeuTavsebelia antibiotikebTan (penicilinebTan, cefalosporinebTan, eriTromicinTan, tetraciklinTan da B amfotericinTan) da proteolizur fermentebTan. amcirebs penicilinebis, cefalosporinebis, tetraciklinis Sewovas da amitom maTi miReba unda moxdes acetilcisteinis SigniT miRebidan 2 saaTis Semdeg. liTonTan, rezinTan Sexebisas warmoiqmneba sulfidebi damaxasiaTebeli suniT. Warbi dozireba dRemde ar gamovlenila Warbi dozirebiT gamowveuli mZime da sicocxlisaTvis saSiSi gverdiTi efeqtebisa da niSnebis SemTxvevebi, eqstremaluri hiperdozirebis pirobebSic ki. simptomebi: SesaZlebelia aRiniSnos diarea, Rebineba, kuWis tkivili, gulZmarva da gulisreva. mkurnaloba: simptomuri Terapia.
gamoSvebis forma asibroqsi 200 mg #24 24 SuSxuna tableti polipropilenis penalSi, daxuruli silikagelis polipropilenis sacobiT. 1 penali muyaos kolofSi furcel-CanarTTan erTad. asibroqsi 200 mg #10 an #20 2 SuSxuna tableti laminirebul stripSi. 5 an 10 laminirebuli stripi muyaos kolofSi furcel-CanarTTan erTad. asibroqsi 600 mg #12 12 SuSxuna tableti polipropilenis penalSi, daxuruli silikagelis polipropilenis sacobiT. 1 penali muyaos kolofSi furcel-CanarTTan erTad. asibroqsi 600 mg #10 an #20 2 SuSxuna tableti laminirebul stripSi. 5 an 10 laminirebuli stripi muyaos kolofSi furcel-CanarTTan erTad. Senaxvis pirobebi inaxeba nestisa da sinaTlisagan dacul adgilas, ara umetes 250C-ze. inaxeba bavSvebisaTvis miuwvdomel adgilas. tabletis amoRebis Semdeg tubi mWidrod unda daixuros. vargisianobis vada 3 weli warmoebis TariRidan. ar gamoiyeneba vargisianobis vadis gasvlis Semdeg. afTiaqidan gacemis wesi farmacevtuli produqtis jgufi III – gamoiyeneba eqimis daniSnulebis gareSe. mwarmoebeli savaWro niSnisa da registraciis sertifikatis mflobelia kompania “rotafarmi”, didi britaneTi (“ROTAPHARM”, GREAT BRITAIN) damzadebulia Sps “vitale XD”-s mier, miaealuse 2/2, 12618 talini, estoneTi (“Vitale-XD Ltd.”, Maealuse 2/2, 12618 Tallin, Estonia)
Semcveli
Semcveli
