Twenty-six million adults in the United States (US), approximately 12 %, have ... Daily consumption ... person in 1997 to 700 mg per person in 2007 [16]. ... given to participants' in their homes followed by a standard health .... (2460/4910).
Kidney Blood Press Res 2016;41:365-373 DOI: 10.1159/000443436 Published online: June 20, 2016
© 2016 The Author(s). © 2016 Published The Author(s) by S. Karger AG, Basel Published by S. Karger AG, Basel www.karger.com/kbr 1423-0143/16/0414-0365$39.50/0 Barbosa-Leiker Prescription Opioid Use and CKD www.karger.com/kbr Accepted: April et 19,al.: 2016
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Original Paper
Association Between Prescription Opioid Use and Biomarkers of Kidney Disease in US Adults Celestina Barbosa-Leikera,b Sterling McPhersona,b Kenn Darathaa,c,d Radica Alicicc,e Robert Shorta,b,c Brad Dieterc Naomi Chaytord John Rolla,b,d Katherine R. Tuttlec,d,e College of Nursing, Washington State University, Spokane, WA; bProgram of Excellence in Addictions Research, Washington State University, Spokane, WA; cProvidence Medical Research Center, Providence Health Care, Spokane, WA; dCollege of Medicine, Washington State University, Spokane, WA; e University of Washington School of Medicine, Seattle, WA a
Key Words Analgesics • Chronic kidney disease • National Health and Nutrition Examination Survey • Opioids Abstract Background/Aims: Prescription opioid use is increasing despite concerns about drug safety. We examined relationships between use of analgesics with biomarkers of chronic kidney disease (CKD) in a representative sample of adults in the United States (US). Methods: Participants (n=3980) were from the National Health and Nutrition Examination Survey (NHANES) 2009-2010. Use of any analgesic, prescription opioids, and NSAIDs were compared to referent groups with use of non-analgesic prescription medication or use of no prescription medication. CKD biomarkers including urine albumin-to-creatinine ratio (UACR) and serumcreatinine-based estimated glomerular filtration rate (eGFR; CKD Epidemiology Collaboration: CKD-EPI equation) were analyzed as continuous and binary variables (UACR ≥30 mg/g or eGFR
