Associations Between Ambient Particle Radioactivity ... - AHA Journals
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Associations Between Ambient Particle Radioactivity ... - AHA Journals
Published on behalf of the American Heart Association,. Inc., by Wiley. This is an open access ... also arise because of fallout from nuclear power plants, nuclear accidents, and nuclear weapons testing. A radionuclide may decay by one of ...
ORIGINAL RESEARCH
Associations Between Ambient Particle Radioactivity and Blood Pressure: The NAS (Normative Aging Study) Marguerite M. Nyhan, PhD; Brent A. Coull, PhD; Annelise J. Blomberg, MPH; Carol L.Z. Vieira, PhD; Eric Garshick, MD; Abdulaziz Aba, PhD; Pantel Vokonas, MD; Diane R. Gold, MD, MPH Joel Schwartz, PhD; Petros Koutrakis, PhD
Background-—The cardiovascular effects of low-level environmental radiation exposures are poorly understood. Although particulate matter (PM) has been linked to cardiovascular morbidity and mortality, and elevated blood pressure (BP), the properties promoting its toxicity remain uncertain. Addressing a knowledge gap, we evaluated whether BP increased with higher exposures to radioactive components of ambient PM, herein referred to as particle radioactivity (PR). Methods and Results-—We performed a repeated-measures analysis of 852 men to examine associations between PR exposure and BP using mixed-effects regression models. As a surrogate for PR, we used gross b activity, measured by the US Environmental Protection Agency’s radiation monitoring network. Higher PR exposure was associated with increases in both diastolic BP and systolic BP, for exposures from 1 to 28 days. An interquartile range increase in 28-day PR exposure was associated with a 2.95– mm Hg increase in diastolic BP (95% confidence interval, 2.25–3.66; P
