Attention deficit h Attention deficit hyperactivity disorder in ... - NICE
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Attention deficit h Attention deficit hyperactivity disorder in ... - NICE
Mar 22, 2016 - The content of this evidence summary was up-to-date in March 2016. ... February 2016). Introduction and c
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Attention deficit h hyper yperactivity activity disorder in children and yyoung oung people: guanfacine prolonged-release Evidence summary Published: 22 March 2016 nice.org.uk/guidance/esnm70
Key points from the e evidence vidence The content of this evidence summary was up-to-date in March 2016. See summaries of product characteristics (SPCs), British national formulary (BNF), BNF for children (BNFc) or the MHRA or NICE websites for up-to-date information.
Summary Guanfacine prolonged-release (Intuniv) is a non-stimulant treatment for children and young people with attention deficit hyperactivity disorder (ADHD). In 3 short-term, randomised controlled trials (RCTs) it was more effective than placebo at improving ADHD symptoms, although a beneficial effect on social functioning was not consistently shown. The most frequently reported adverse reactions for guanfacine prolonged-release were somnolence, headache, fatigue, upper abdominal pain and sedation. Serious adverse reactions include hypotension, weight increase, bradycardia and syncope. No studies directly compared the efficacy and safety of guanfacine prolonged-release with other active treatments for ADHD. Regulatory status: Guanfacine prolonged-release (Intuniv) received a European marketing authorisation for use in ADHD in September 2015. It was launched in the UK in February 2016. Guanfacine prolonged-release is licensed for the treatment of ADHD in children and young people
Attention deficit hyperactivity disorder in children and young people: guanfacine prolonged-release (ESNM70) aged 6–17 years old for whom stimulants are not suitable, not tolerated or have been shown to be ineffective. It is not licensed for use in combination with stimulants or for adults with ADHD. Effectiv Effectiveness eness
Safety
In 1 short-term RCT, dose-optimised guanfacine prolonged-release was more effective than placebo at improving ADHD symptoms in children and young people aged 6–17 years (about half of whom had previously been treated with stimulant medication; p
