pre-induction with midazolam. M. D. Brunner*, M. R. Nel, R. Fernandes, C. Thornton and D. E. F. Newton. Department of Anaesthetics and Intensive Care, ...
British Journal of Anaesthesia 89 (2): 325±7 (2002)
SHORT COMMUNICATION Auditory evoked response during propofol anaesthesia after pre-induction with midazolam M. D. Brunner*, M. R. Nel, R. Fernandes, C. Thornton and D. E. F. Newton Department of Anaesthetics and Intensive Care, Division of Surgery, Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College, Northwick Park Hospital, Watford Road, Harrow, Middlesex HA1 3UJ, UK *Corresponding author Background. In clinical use, midazolam reduces the dose requirement for propofol. We studied the effect of midazolam given before anaesthesia on the amount of propofol needed and the time taken, to achieve loss of consciousness (LOC) in 20 patients. Methods. We compared the auditory evoked responses (AER) in these patients with those in a group of 20 patients who were not given midazolam. Results. LOC, as de®ned by a loss of response to verbal command and eyelash re¯ex, occurred after 113 (95% CI, 99±131) s in the control group and 75 (56±101) s in the midazolam group (P
