Original Article
http://dx.doi.org/10.3349/ymj.2012.53.2.427 pISSN: 0513-5796, eISSN: 1976-2437
Yonsei Med J 53(2):427-432, 2012
Beneficial Effects of Adding Ketamine to Intravenous PatientControlled Analgesia with Fentanyl after the Nuss Procedure in Pediatric Patients Moon Ho Cha, Ji Hye Eom, Yoon Sook Lee, Woon Young Kim, Young Cheol Park, Sam Hong Min, and Jae Hwan Kim Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, Seoul, Korea. Received: March 30, 2011 Revised: May 17, 2011 Accepted: June 21, 2011 Corresponding author: Dr. Jae Hwan Kim, Department of Anesthesiology and Pain Medicine, Korea University College of Medicine, 123 Jeokgeum-ro, Danwon-gu, Ansan 425-707, Korea. Tel: 82-31-412-5295, Fax: 82-31-412-5294 E-mail:
[email protected] ∙ The authors have no financial conflicts of interest.
Purpose: The aim of this prospective, double-blind, randomized study was to investigate the analgesic effects of low-dose ketamine on intravenous patient-controlled analgesia (IV-PCA) with fentanyl for pain control in pediatric patients following the Nuss procedure for pectus excavatum. Materials and Methods: Sixty pediatric patients undergoing the Nuss procedure were randomly assigned to receive fentanyl (Group F, n=30) or fentanyl plus ketamine (Group FK, n=30). Ten minutes before the end of surgery, following the loading dose of each solution, 0.5 μg/kg/hr of fentanyl or 0.5 μg/kg/hr of fentanyl plus 0.15 mg/kg/hr of ketamine was infused via an IV-PCA pump (basal rate, 1 mL/hr; bolus, 0.5 mL; lock out interval, 30 min). Fentanyl consumption, pain score, ketorolac use, nausea/vomiting, ondansetron use, pruritus, respiratory depression, hallucination, dreaming, and parent satisfaction with pain control were measured throughout the 48 hours following surgery. Results: The pain scores, ketorolac use, and fentanyl consumption of Group FK were significantly lower than in Group F (p
