high intensity interval training rehabilitation program [with (n=5) or without (n=4) ... Results: After 3 months of exercise training all patients significantly improved.
Beneficial effects of exercise training
high intensity interval training rehabilitation program [with (n=5) or without (n=4) the addition of strength training] of 36 sessions, 3 times per week. All patients performed a symptom-limited cardiopulmonary exercise test before and after the completion of the program. At the same time they underwent percutaneous needle biopsies of the vastus lateralis muscle. Pathology measurements included the skeletal muscle fiber type distribution and cross sectional area (CSA) that were determined by adenosine triphosphatase staining. The mRNA expression of IGF-1Ea, IGF-1Eb, IGF-IEc and IGF-1R was investigated by quantitative realtime PCR. Results: After 3 months of exercise training all patients significantly improved their exercise capacity. A significant increase of the CSA of type I fibers from 4519±1071 to 4856±1076 μm2 (p=0.001) and of type II fibers from 4420±1057 to 4925±1049 μm2 (p=0.001) was found and there was a significant reshift to aerobic fibers from 45±9% to 53±7% (p=0.006). An increased expression of the IGF-1Ea, IGF-1Eb and IGF-1Ec transcripts was found following the exercise training compared with the pre-exercise expression levels [1.8±0.9 (p=0.02), 1.7±0.8 (p=0.03) and 2.1±1.4 (p=0.04) fold changes, respectively]. IGF-1R expression levels showed no changes. The percentage increase of CSA found to be correlated with the increase of IGF-1Eb (r=0.72, p=0.03). No significant changes between the two types of exercise were found. Conclusions: The results indicate that high intensity interval exercise training can improve aerobic capacity and may have an anabolic effect by increasing the cross sectional area of muscle fibers in HF patients, possibly via IGF-1 isoformspecific actions. There is also evidence that the pathologic shif to anaerobic fiber phenotype present in HF patients may be reversed by this intervention.
P5788 | BEDSIDE New model of home telemonitored nordic walking training in heart failure patients also those with cardiovascular implantable electronic devices:safety,effectiveness, adherence-randomized control study
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P5789 | BEDSIDE Genetic components of exercise tolerance, endothelial and autonomic function and their changes by exercise training in patients with coronary artery disease S. Onkelinx 1 , V. Cornelissen 2 , K. Goetschalckx 2 , T. Thomaes 2 , D. Scheepers 2 , P. Verhamme 2 , R. Fagard 2 , L. Vanhees 2 . 1 Fontys university of applied sciences, Eindhoven, Netherlands; 2 KULeuven, Leuven, Belgium Objective: In patients with Coronary Artery Disease (CAD), there is considerable intra-individual variation in peak oxygen uptake (peakVO2), Heart Rate Variability (HRV) and Flow-Mediated Dilatation (FMD), as well as in the response of these phenotypes to physical training. The aim of this study was to identify genetic variants that are associated with these phenotypes and/or with their change after a rehabilitation program, and to determine how much can be explained by these genetic variants. Methodology: We recruited CAD patients who underwent a cardiac rehabilitation program. Exercise testing and the evaluation of endothelial function (assessment of FMD) and of autonomic function (assessment of HRV parameters) were performed prior to and after the rehabilitation program. Genetic Predisposition Scores (GPSs) were generated for each phenotype based on 75 selected Single Nucleotide Polymorphisms (SNPs). Results: At baseline, 260 CAD patients were included in the study. Baseline and follow-up data of peakVO2, HRV and FMD were available for 204 patients. Cardiac rehabilitation increased peakVO2 by 21.7±15.8% (p
