Biobanking committee in each institute belonging to G7. ⢠Aims: management of the samples, and of the regulatory, scientific and strategic aspects of the biobank.
PIBnet: What has been done so far?
Reminder of the aims: valorization of biological bioresources Creation of a network for laboratories aligned with public health missions using cutting-edge technology helping to realise ambitious projects within the field of infectious and tropical diseases enhancing the biological heritage at an international level sharing common constraints therefore optimising the investments virtually gathering the bioresources and associated data
Reminder of the procedure A first group of 7 institutes (G7) • Guyane • Madagascar • Tunis • Côte-d’Ivoire • Dakar • Cambodge • Cameroun Work within the G7 • check feasability • finalize the processes and make the necessary choices • ensure compliance and involvment
PIBnet The way to … … coordinate and share expertise … develop specific tools … increase the visibility of the network … share cutting-edge technological tools in the field of public health What has been done in 2015: Start of training on Biobanking focus group on Bioinformatic and IT Dedicated platform, open to the institutes from the Network
First realizations within the institutes Biobanking committee in each institute belonging to G7 • Aims: management of the samples, and of the regulatory, scientific and strategic aspects of the biobank Upgrading of existing facilities • Equipments to maintain or upgrade the cool chain (temperatures, alarms, traçability, …) • Layout, secure-access system Training: 1st cession 18-19 January 2016 • Training, with funding for 2 persons of each institutes of the G7
IT system to be built Different directions to improve the system First step for tools and softwares For the « core » Increasing of computer capacity Data storage Choice of data storage location Purchase of the equipement dédicated to the network Development of specific bioinformatic tools
Examples from the Network, representative of the different situations
Biobanking at Institut Pasteur du Cambodge Prepared from Sara Castillo’slides Master 2 Biobanking Management (ESTBB – LYON)
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Context What is a collection at IPC ? - Viruses - Bacteria - Parasites - Arthropods - Animal and human samples - (blood, cells, tissues ..) - others
Number of collections at IPC Unit
Number of collections identified
Malaria
23 collections
Epidemiology and PH– Clinical Trials
8 collections
HIV/AIDS and Hepatitis Immunology Immunology G4
12 collections 6 collections 1 collection
Food and water Analyses
5 collections
Virology Total
13 collections
68 collections
Storage of the IPC collections : -80°c, -20°c, +4°c, RT, dry, alcohol, in each unit
Every unit has its own storage and management process Lack of traceability Quantitative and qualitative variability depending on unit / collections
Methods
Short term objectives • Understand the context of biological resources at IPC (SWOT analysis) • Identify needs in biobanking (with unit’s heads and direction) • Propose a strategy to units
Medium term objectives • Biological Resources Management (cartography, flow of samples, storage, data format, good practices, security, standard documents, transport and MTA (Nagoya), ethical and administrative rules …) • Skill and help in management • Valorisation (use of samples, exchanges, publications, ..)
Methods • Recruitment of a BioBank manager (Sara Castillo + Technician: Nginh Chao, next : Stephane Grenier Graduated in Master Biobanking Management)
• • • • •
Identify Unit sample manager : Meeting, Discussion: 12 sample managers Identify stakeholder : Power / Interest matrix Describe collections : Meeting and Questionnaire Complete database (export from current unit’s databases into new software) Regular meetings of the committee
Organization IPC Direction
Steering Committee
Management Committee: Ph Dussart
Head of Unit
Biobank Coordinator + technician
Biobank : Quality, Project management, coordination
Unit Biobank : 8 sites Head of Unit
Sample Manager Quality Manager
IT, HSeQE
Difficulties • Difficulties to change old (but sometime efficient !) habits and behaviors (“why changing, it already works ?”, “demonstrate improvement”, ..)
• Huge differences between units, but only one biobank expected • Difficulty to harmonize (8 units, > 68 collections)
• Need to identify, train, convince 1 or several “representative” /unit • Export – transfer data from current databases • Slow ownership in general
• Cost (RH, equipment, software, ..) (Thanks to PibNet) • Software (strains and for Human and animal samples )
Institut Pasteur de Côte d'Ivoire
PROJET PIBNET Centre de Ressources Biologiques / CeReB Institut Pasteur de Côte d’Ivoire Pr Dosso Mireille Réunions Directeurs Juin 2016/ Lyon
GOUVERNANCE DU CeReB
Direction IPCI
Comite pilotage du CeReB (Décision Nᵒ21/17 Juin 2015/IPCI)
Comité scientifique institutionnel
DÉPARTEMENT CeReB Chef de département
UBQC Dr Doumbia S
UCB Dr Marcelle Money
UGRM Dr Cissé S
INVENTORY OF BIOLOGICAL RESOURCES (CIM10 codification) I- COLLECTIONS HUMAINES
GLOBALLY Adminitrative organization • Steering committee • Recrutement of qualified personnel, equipments (MALDI-TOF), IT, security management) • Reinforcement of capacities: HR, data management, ingeneer, informatician, … Quality system management Organization of the data management • constitution of the data base for flu 2007-2015 • Catalog Pibnet
MAJOR QUESTIONS TO FACE: WHAT STRATEGY TO ADOPT? WHICH TO CHOOSE: 1- Systematic centres and from care 2- Targeted
conservation:
from reference
collections:
which projects do already exist? Is there some preexisting demand Links with the scientific priorities of the institute
MAJOR QUESTIONS TO FACE: Include the Nagoya protocol in the questions (anticipate those issues) Have access to innovative technology platforms, and include proper research on biobanking Link biobanking and translational science/ clinical research How to integrate service delevery? Which is the best economic model (accessibility/ rentability)?
PIBnet: what’s next?
PERSPECTIVES
Perspectives inside IPIN Continuation of the training for technicians for managers (graduation?) e-learning specific tool
Pursuing of the inventory Creation of the Catalog Biobanking community animation Dedicated opened collaborative Portal/Website Extension to the 2nd wave of institutes
PIBnet : an IT system in progress Institut Pasteur is moving to establish a global framework for reproducible research with unified bio-banking, data storage, management and analysis. Resources will be connected and shared through the IP cloud for data analysis.
Projects will be supported by this infrastructure
Cloud for data management and analysis
