contralateral forepaw adjusting steps and dopamine depletion after medial forebrain bundle lesions with. 6-hydroxydopamine. Depletion of striatal dopamine by ...
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Neuroscience Vol. 88, No. 2, pp. 617–628, 1999 Copyright 1998 IBRO. Published by Elsevier Science Ltd Printed in Great Britain. All rights reserved 0306–4522/99 $19.00+0.00 S0306-4522(98)00217-6
BIOCHEMICAL AND ANATOMICAL CHARACTERIZATION OF FOREPAW ADJUSTING STEPS IN RAT MODELS OF PARKINSON’S DISEASE: STUDIES ON MEDIAL FOREBRAIN BUNDLE AND STRIATAL LESIONS J.-W. CHANG,† S. R. WACHTEL,‡ D. YOUNG and U.-J. KANG* Departments of Neurology, Pharmacological and Physiological Sciences, and Committee on Neurobiology, The University of Chicago, Chicago, IL 60637, U.S.A. Abstract––Deficits in forepaw adjusting steps in rats have been proposed as a non-drug-induced model of the akinesia associated with Parkinson’s disease. The present study examined the relationship between contralateral forepaw adjusting steps and dopamine depletion after medial forebrain bundle lesions with 6-hydroxydopamine. Depletion of striatal dopamine by >80% resulted in dramatic reductions in the ability of rats to make adjusting steps, but rats with
