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Int. J. Med. Sci. 2013, Vol. 10

Ivyspring

International Publisher

508

International Journal of Medical Sciences

Research Paper

2013; 10(5):508-514. doi: 10.7150/ijms.4476

Body Temperature during Hibernation Is Highly Correlated with a Decrease in Circulating Innate Immune Cells in the Brown Bear (Ursus arctos): A Common Feature among Hibernators? Berolla Sahdo1, Alina L. Evans2,3, Jon M. Arnemo2,4, Ole Fröbert5, Eva Särndahl1,5,  and Stéphane Blanc6  1. 2. 3. 4. 5. 6.

Department of Clinical Medicine, School of Health and Medical Sciences, Örebro University, SE-701 82 Örebro, Sweden. Department of Forestry and Wildlife Management, Hedmark University College, Campus Evenstad NO-2418 Elverum, Norway. Section of Arctic Veterinary Medicine, Norwegian School of Veterinary Science, NO-9292 Tromsø, Norway. Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences, SE-901 83 Umeå, Sweden. Department of Cardiology, Örebro University Hospital, SE-701 85 Örebro, Sweden. Université de Strasbourg, IPHC, 23 rue Becquerel 67087 Strasbourg, France, CNRS, UMR7178, 67037 Strasbourg, France.

 Corresponding author: Eva Särndahl, School of Health and Medical Sciences/KFC, Örebro University Hospital, SE-701 85 Örebro, Sweden. Phone: +46 19 602 6653 (+46 707 43 0897 cell) Fax: +46 19 602 6650 e-mail: [email protected]. © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/ licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

Received: 2012.04.16; Accepted: 2013.02.10; Published: 2013.03.11

Abstract Background: Hibernation involves periods of severely depressed metabolism (torpor) and decreases in body temperature (Tb). Small arctic mammals (