Brain Activity Within Regions Involved in Stress

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11/12/17, 9;04 PM. Abstract 15598: Brain Activity Within Regions Involved in Stress Perc…T/CT in a Resource-limited, Community-based Population | ...
Abstract 15598: Brain Activity Within Regions Involved in Stress Perc…T/CT in a Resource-limited, Community-based Population | Circulation

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Abstracts and presentations are embargoed for release at date and time of presentation or time of AHA/ASA news event. Failure to honor embargo policies (http://newsroom.heart.org/newsmedia/embargo-policy) will result in the abstract being withdrawn and barred from presentation. LIFESTYLE & BEHAVIORAL MEDICINE SESSION TITLE: CLINICAL RISK FACTORS AND BIOMARKERS IN RISK PREDICTION

Abstract 15598: Brain Activity Within Regions Involved in Stress Perception Associates Directly With Vascular Inflammation by 18-FDG PET/CT in a Resource-limited, Community-based Population Joshua P Rivers, Valerie Mitchell, Abhishek Chaturvedi, Aditya A Joshi, Amit K Dey, Faren Grant, Joel Adu-Brimpong, Samantha Thomas, Chaarushi Ahuja, Nehal N Mehta, Tiffany M Powell-Wiley

Circulation. 2017;136:A15598

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http://circ.ahajournals.org/content/136/Suppl_1/A15598

This Issue Circulation November 1, 2017, Volume 136, Issue Suppl 1 Page 1 of 4

Abstract 15598: Brain Activity Within Regions Involved in Stress Perc…T/CT in a Resource-limited, Community-based Population | Circulation

Background: Psychosocial stress and depression correlate with cardiovascular (CV) events; however, association of objective physiologic measures of these psychological stressors with the development of CV disease is unclear. Thus, we examined the relationship between resting-state stress perception center activation, as measured by amygdala FDG uptake, and vascular inflammation (VI) by 18-FDG PET/CT in a resource-limited community-based (CB) cohort. Hypothesis: We hypothesized that amygdala activity by FDG uptake would directly associate with VI by 18-FDG PET/CT in a resource-limited CB cohort.

11/12/17, 9(04 PM

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Methods: Patients from the Washington, D.C. Cardiovascular Health and Needs Assessment, an assessment in predominantly African-American churches in resource-limited D.C. areas, underwent detailed phenotyping with cardiometabolic markers and whole-body 18-FDG PET/CT to measure VI and stress perception center activity (amygdala activity). Results: The cohort (N=31) was consecutively recruited, African American, middle-aged, and predominantly female (Table 1). These patients were obese, pre-hypertensive, and had abnormal lipid levels. In univariable analyses, VI significantly associated with sex, hypertension treatment, and CV disease risk by Framingham risk score (FRS) (p