John L. VandeBerg, Jean W. MacCluer, and John Blangero ..... 312â325. 9. Almasy L, Dyer TD, Blangero J: Bivariate quantitative trait linkage analysis: pleiotropy ... Kissebah AH, Sonnenberg GE, Myklebust J, Goldstein M, Broman K, James.
second phase insulin secretion, they approached statisti- ... Estimated second phase .... DeFronzo RA: Lilly Lecture 1987: The triumvirate: -cell, muscle, liver: a.
To this end, we modified the ILINK option of the LINKAGE package, version 5.04. While maximizing the log likelihood over , the recombination fraction was fixed ...
Genetic Liability of Type 1 Diabetes and the Onset Age .... FIG. 2. Kaplan-Meier diabetes-free survival curves in MZ cotwins by ..... ment of Human Genetics, 1991.
transhydrogenase (Nnt) on mouse chromosome 13, a nu- ... welfare guidelines and project license restrictions under controlled light (12-h light and 12-h dark ...
the 3Molecular Genetics Program, Benaroya Research Center and Department of Immunology, University of Washington School of Medicine, Seattle, Wash-.
dysfunction in late-onset diabetic subjects carrying homozygous mutations in transcription factors NeuroD1 and Pax4. Metabolism 51:1161â1165, 2002. 6.
Francis Vasseur,1 Bernard Guy-Grand,2 and Philippe Froguel1,3. The Lim domain homeobox gene (Isl-1) is a positional candidate gene for obesity that maps ...
Samuel Marguerat,1 William Y.S. Wang,2 John A. Todd,2 and Bernard Conrad1 ..... Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C,.
May 5, 2015 - John B. Whitfield, Khairunnessa Rahman, Paul S. Haber, Christopher ...... MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF,.
Joanna M.M. Howson,1 Alex C. Lam,1 Luc J. Smink,1 David A. Savage,2 Dag E. Undlien,3 ..... Ionescu-Tirgovi°te C, Guja C, Herr M, Cucca E, Welsh K, Bunce M,.
Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C,. Hulme J ... Guja C, Marshall S, Welsh K, Merriman M, Smith A, Todd JA, Ionescu.
studies have suggested that it has a strong genetic basis. We performed a genome-wide quantitative trait linkage scan for loci influencing BMI in 573 pedigrees ...
Received for publication 15 November 2002 and accepted in revised form 30. January .... C-C.C. HUNG AND ASSOCIATES. DIABETES, VOL. 52, MAY 2003. 1289 .... Lee HK, Lee YK, Park SH, Kim YS, Lee JW, Kwon HB, Soh J, Moore DD,.
between the serologically defined HLA antigens and the HLA speeificity .... Cw4. Cwl. Cw6. DR1. DR4. DR1. DR6. DR1. DR2. DR8. Stimul itor cells. A2. A2. AI.
Evidence for Linkage and Association Between the. Insulin Gene .... H N F - 1 , hepatocyte nuclear factor- 1 ; MODY, maturity-onset diabetes of the young ..... ing method for hepatocyte nuclear factor 1 alpha frame-shift mutations: prevalence in ...
the principle of pharmacogenetics applied in diabetes treatment. Diabetes 53:2713â2718, 2004. Neonatal diabetes may be defined as hyperglyce-.
The aim of this study was to investigate whether muta- tions in hepatocyte nuclear factor (HNF)-4 , a tran- scription factor homologous to HNF-4 , contribute to.
mia diagnosed within the first 3 months of life. (1). Transient ... one slice of white bread and 100 ml milk or yogurt or Boost High Protein (6 ml/kg, maximum 300 ...
A( C A )n dinucleotide repeat sequence â2.1 kb upstream of the transcription start site of the aldose reductase gene has been found to be strongly associated ...
Manami Hara, Tom H. Lindner, Veronica P. Paz, Xiaoyu Wang, Naoko Iwasaki, Makiko Ogata,. Yasuhiko Iwamoto, and Graeme I. Bell. Diabetes is a group of ...
ropean Monitor lizards have recently been revised by Conrad et al. (2009 .... E. 5 mm. Fig. 1. Varanid lizard Varanus sp. from Can Mas, early Miocene, IPS.
ANTICONVULSANT EFFECT OF SOUR ORANGE ... effects.2 Sour orange (Citrus aurantium L) is one ... the flowers of this plant has been used to cure seizures ...
Keywords: autism spectrum disorder; autoimmunity; infection; glutamate; single-molecule .... ed for NMDAR-Ab, only one healthy subject free of any neurological or ... Table I. ADOS (Autism Diagnostic Observation Schedule) 1 module 4 al-.
TUB is the founding-member of the tubby-like proteins and is conserved among vertebrate genomes (2). Interest- ingly, a loss of function mutation of tub results ...
Brief Genetics Report Identification of TUB as a Novel Candidate Gene Influencing Body Weight in Humans Ronit Shiri-Sverdlov,1 Anne Custers,1 Jana V. van Vliet-Ostaptchouk,1 Patrick J.J. van Gorp,1 Patrick J. Lindsey,2 Jonathan H.O. van Tilburg,3 Sasha Zhernakova,3 Edith J.M. Feskens,4 Daphne L. van der A,4 Martijn E.T. Dolle´,5 Timon W. van Haeften,3 Bobby P.C. Koeleman,3 Marten H. Hofker,1 and Cisca Wijmenga3
Previously, we identified a locus on 11p influencing obesity in families with type 2 diabetes. Based on mouse studies, we selected TUB as a functional candidate gene and performed association studies to determine whether this controls obesity. We analyzed the genotypes of 13 single nucleotide polymorphisms (SNPs) around TUB in 492 unrelated type 2 diabetic patients with known BMI values. One SNP (rs1528133) was found to have a significant effect on BMI (1.54 kg/m2, P ⴝ 0.006). This association was confirmed in a population enriched for type 2 diabetes, using 750 individuals who were not selected for type 2 diabetes. Two SNPs in linkage disequilibrium with rs1528133 and mapping to the 3ⴕ end of TUB, rs2272382, and rs2272383 also affected BMI by 1.3 kg/m2 (P ⴝ 0.016 and P ⴝ 0.010, respectively). Combined analysis confirmed this association (P ⴝ 0.005 and P ⴝ 0.002, respectively). Moreover, comparing 349 obese subjects (BMI >30 kg/m2) from the combined cohort with 289 normal subjects (BMI
